MRE11A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.00467429
2nuclear pore organization (GO:0006999)4.91154754
3DNA unwinding involved in DNA replication (GO:0006268)4.87271781
4DNA strand elongation involved in DNA replication (GO:0006271)4.68158220
5replication fork processing (GO:0031297)4.63988007
6DNA replication initiation (GO:0006270)4.51987451
7DNA strand elongation (GO:0022616)4.46728218
8telomere maintenance via semi-conservative replication (GO:0032201)4.32106737
9protein localization to kinetochore (GO:0034501)4.29661827
10kinetochore organization (GO:0051383)4.17223731
11centriole replication (GO:0007099)3.99712564
12telomere maintenance via recombination (GO:0000722)3.99703993
13mitotic nuclear envelope disassembly (GO:0007077)3.97890286
14mitotic recombination (GO:0006312)3.95215088
15mitotic chromosome condensation (GO:0007076)3.93454308
16regulation of mitotic spindle checkpoint (GO:1903504)3.90209916
17regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.90209916
18* negative regulation of DNA-dependent DNA replication (GO:2000104)3.89777988
19DNA double-strand break processing (GO:0000729)3.88372962
20protein localization to chromosome, centromeric region (GO:0071459)3.83896961
21pore complex assembly (GO:0046931)3.83695392
22mitotic sister chromatid cohesion (GO:0007064)3.77405408
23DNA replication checkpoint (GO:0000076)3.74903139
24mitotic metaphase plate congression (GO:0007080)3.73384498
25DNA replication-dependent nucleosome assembly (GO:0006335)3.72356134
26DNA replication-dependent nucleosome organization (GO:0034723)3.72356134
27mitotic sister chromatid segregation (GO:0000070)3.71901193
28meiotic chromosome segregation (GO:0045132)3.70407641
29DNA ligation (GO:0006266)3.70370500
30chromatin remodeling at centromere (GO:0031055)3.69501917
31sister chromatid segregation (GO:0000819)3.65589393
32* DNA duplex unwinding (GO:0032508)3.65288094
33membrane disassembly (GO:0030397)3.65135070
34nuclear envelope disassembly (GO:0051081)3.65135070
35* DNA geometric change (GO:0032392)3.64702150
36regulation of helicase activity (GO:0051095)3.61388010
37IMP biosynthetic process (GO:0006188)3.59306051
38CENP-A containing nucleosome assembly (GO:0034080)3.59030156
39regulation of histone H3-K9 methylation (GO:0051570)3.54606746
40* telomere maintenance via telomere lengthening (GO:0010833)3.54305606
41regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.49758901
42folic acid-containing compound biosynthetic process (GO:0009396)3.47815697
43kinetochore assembly (GO:0051382)3.41526865
44* recombinational repair (GO:0000725)3.41313615
45* double-strand break repair via homologous recombination (GO:0000724)3.40621776
46* non-recombinational repair (GO:0000726)3.40508507
47* double-strand break repair via nonhomologous end joining (GO:0006303)3.40508507
48DNA replication-independent nucleosome assembly (GO:0006336)3.39012746
49DNA replication-independent nucleosome organization (GO:0034724)3.39012746
50metaphase plate congression (GO:0051310)3.38827297
51nucleotide-excision repair, DNA gap filling (GO:0006297)3.35593065
52maturation of SSU-rRNA (GO:0030490)3.35487425
53proteasome assembly (GO:0043248)3.34804513
54ribosomal small subunit assembly (GO:0000028)3.33247191
55formation of translation preinitiation complex (GO:0001731)3.32597329
56attachment of spindle microtubules to kinetochore (GO:0008608)3.30891548
57nucleobase biosynthetic process (GO:0046112)3.28949046
58mitotic spindle checkpoint (GO:0071174)3.28768647
59resolution of meiotic recombination intermediates (GO:0000712)3.28593511
60somatic hypermutation of immunoglobulin genes (GO:0016446)3.25183887
61somatic diversification of immune receptors via somatic mutation (GO:0002566)3.25183887
62RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.21523008
63regulation of centrosome duplication (GO:0010824)3.20330179
64negative regulation of DNA recombination (GO:0045910)3.20051338
65establishment of chromosome localization (GO:0051303)3.19803072
66* telomere maintenance (GO:0000723)3.19051577
67DNA catabolic process, exonucleolytic (GO:0000738)3.18207795
68* mitotic G2/M transition checkpoint (GO:0044818)3.17416109
69DNA topological change (GO:0006265)3.15768208
70* telomere organization (GO:0032200)3.15504755
71* DNA conformation change (GO:0071103)3.14902833
72protein K6-linked ubiquitination (GO:0085020)3.13960882
73regulation of sister chromatid segregation (GO:0033045)3.13926032
74regulation of mitotic sister chromatid separation (GO:0010965)3.13926032
75regulation of mitotic sister chromatid segregation (GO:0033047)3.13926032
76IMP metabolic process (GO:0046040)3.13649071
77positive regulation of histone H3-K4 methylation (GO:0051571)3.13631744
78negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.13361019
79regulation of telomere maintenance via telomerase (GO:0032210)3.13290911
80mismatch repair (GO:0006298)3.13091836
81histone exchange (GO:0043486)3.11692233
82regulation of spindle organization (GO:0090224)3.11335742
83protein localization to chromosome (GO:0034502)3.10435508
84centrosome organization (GO:0051297)3.09183048
85chromatin assembly or disassembly (GO:0006333)3.07799923
86heterochromatin organization (GO:0070828)3.07412569
87positive regulation of chromosome segregation (GO:0051984)3.07225804
88* synapsis (GO:0007129)3.05044314
89negative regulation of histone methylation (GO:0031061)3.04841109
90regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.04792165
91somatic diversification of immunoglobulins (GO:0016445)3.04462228
92translesion synthesis (GO:0019985)3.03560417
93response to X-ray (GO:0010165)3.02367386
94mitotic spindle assembly checkpoint (GO:0007094)3.02106709
95regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.01493583
96somatic recombination of immunoglobulin gene segments (GO:0016447)3.01449619
97regulation of double-strand break repair via homologous recombination (GO:0010569)2.99682704
98dosage compensation (GO:0007549)2.98109731
99somatic diversification of immune receptors (GO:0002200)2.97854980
100* double-strand break repair (GO:0006302)2.96910695
101chromatin assembly (GO:0031497)2.95923513
102regulation of centrosome cycle (GO:0046605)2.95354543
103regulation of nuclear cell cycle DNA replication (GO:0033262)2.95021742
104* base-excision repair (GO:0006284)2.93744415
105maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.92926941
106regulation of centriole replication (GO:0046599)2.92073792
107regulation of chromosome segregation (GO:0051983)2.90910159
108negative regulation of chromosome segregation (GO:0051985)2.89874416
109* regulation of DNA endoreduplication (GO:0032875)2.89096836
110purine nucleobase biosynthetic process (GO:0009113)2.88201767
111positive regulation of mitotic sister chromatid separation (GO:1901970)2.87621439
112positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.87621439
113positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.87621439
114ATP-dependent chromatin remodeling (GO:0043044)2.87584287
115regulation of mitotic metaphase/anaphase transition (GO:0030071)2.87439505
116spindle checkpoint (GO:0031577)2.85220297
117negative regulation of mitotic sister chromatid separation (GO:2000816)2.83136072
118negative regulation of mitotic sister chromatid segregation (GO:0033048)2.83136072
119negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.83136072
120negative regulation of sister chromatid segregation (GO:0033046)2.83136072
121spindle assembly checkpoint (GO:0071173)2.82420648
122chromosome condensation (GO:0030261)2.81364060
123chromosome segregation (GO:0007059)2.81355495
124regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.80300662
125ribosome assembly (GO:0042255)2.80049447
126somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.78168349
127somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.78168349
128isotype switching (GO:0045190)2.78168349
129regulation of sister chromatid cohesion (GO:0007063)2.78132712
130postreplication repair (GO:0006301)2.77281258
131ribosomal large subunit biogenesis (GO:0042273)2.77212714
132viral transcription (GO:0019083)2.77114936

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.09625811
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.57866010
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.88831073
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.54866559
5EGR1_19374776_ChIP-ChIP_THP-1_Human2.96787863
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.93037696
7* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.82292926
8* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.57464066
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.56115991
10E2F1_21310950_ChIP-Seq_MCF-7_Human2.47764808
11* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.35579278
12MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.28657952
13AR_21909140_ChIP-Seq_LNCAP_Human2.26514448
14* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.25649951
15NELFA_20434984_ChIP-Seq_ESCs_Mouse2.22412753
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.21276900
17EWS_26573619_Chip-Seq_HEK293_Human2.14512028
18MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.10069079
19FUS_26573619_Chip-Seq_HEK293_Human2.06713068
20KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.02478519
21E2F7_22180533_ChIP-Seq_HELA_Human11.5329846
22ZNF274_21170338_ChIP-Seq_K562_Hela1.99348536
23XRN2_22483619_ChIP-Seq_HELA_Human1.95595943
24MYC_22102868_ChIP-Seq_BL_Human1.89884266
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.86940807
26GABP_17652178_ChIP-ChIP_JURKAT_Human1.86578762
27VDR_23849224_ChIP-Seq_CD4+_Human1.84879644
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.84142508
29* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.81901416
30ETS1_20019798_ChIP-Seq_JURKAT_Human1.77373903
31ELF1_17652178_ChIP-ChIP_JURKAT_Human1.74790498
32VDR_22108803_ChIP-Seq_LS180_Human1.73447250
33CREB1_15753290_ChIP-ChIP_HEK293T_Human1.71561471
34ELK1_19687146_ChIP-ChIP_HELA_Human1.68931594
35FOXP3_21729870_ChIP-Seq_TREG_Human1.68429956
36* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.67700630
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.67617359
38TP63_19390658_ChIP-ChIP_HaCaT_Human1.61495185
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.59880316
40TTF2_22483619_ChIP-Seq_HELA_Human1.59862380
41* HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.55593287
42FLI1_27457419_Chip-Seq_LIVER_Mouse1.53706706
43CIITA_25753668_ChIP-Seq_RAJI_Human1.53296210
44E2F1_18555785_ChIP-Seq_MESCs_Mouse1.52617801
45POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.51078781
46YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.51014041
47NANOG_18555785_ChIP-Seq_MESCs_Mouse1.45397994
48PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44776396
49DCP1A_22483619_ChIP-Seq_HELA_Human1.41727437
50SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.38378047
51CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.37548728
52* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.37532906
53SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.35258565
54FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.34895219
55SALL1_21062744_ChIP-ChIP_HESCs_Human1.34411286
56* SRF_21415370_ChIP-Seq_HL-1_Mouse1.32902562
57ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.32143608
58HOXB4_20404135_ChIP-ChIP_EML_Mouse1.30340013
59IGF1R_20145208_ChIP-Seq_DFB_Human1.28710825
60TAF15_26573619_Chip-Seq_HEK293_Human1.28284951
61GABP_19822575_ChIP-Seq_HepG2_Human1.26974659
62KDM5A_27292631_Chip-Seq_BREAST_Human1.25124267
63THAP11_20581084_ChIP-Seq_MESCs_Mouse1.24823671
64ZFX_18555785_ChIP-Seq_MESCs_Mouse1.23561784
65FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.22786386
66NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.21982639
67CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.21070967
68SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.20922300
69ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.17554902
70IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.15634165
71SOX2_18555785_ChIP-Seq_MESCs_Mouse1.15115475
72* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.14687628
73P300_19829295_ChIP-Seq_ESCs_Human1.13138492
74POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.12556942
75TFEB_21752829_ChIP-Seq_HELA_Human1.12513861
76* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.11007746
77PADI4_21655091_ChIP-ChIP_MCF-7_Human1.10812948
78POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.10360585
79NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.10059074
80* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.09969025
81VDR_21846776_ChIP-Seq_THP-1_Human1.08796071
82PCGF2_27294783_Chip-Seq_ESCs_Mouse1.07682224
83GATA1_22025678_ChIP-Seq_K562_Human1.07296270
84ER_23166858_ChIP-Seq_MCF-7_Human1.06706697
85RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06679701
86STAT3_1855785_ChIP-Seq_MESCs_Mouse1.05811500
87EZH2_27294783_Chip-Seq_NPCs_Mouse1.05065260
88KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.04629969
89NOTCH1_21737748_ChIP-Seq_TLL_Human1.03948144
90IRF1_19129219_ChIP-ChIP_H3396_Human1.02824093
91FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.02347692
92MYC_18940864_ChIP-ChIP_HL60_Human1.01632445
93SPI1_23547873_ChIP-Seq_NB4_Human1.00049973
94PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.99738107
95AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99128388
96KLF4_18555785_ChIP-Seq_MESCs_Mouse0.98552518
97* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.98475417
98ZFP57_27257070_Chip-Seq_ESCs_Mouse0.98415893
99MYB_26560356_Chip-Seq_TH2_Human0.95864563
100EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.95615262
101HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.93585362
102GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93475674
103FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.92852843
104POU5F1_16153702_ChIP-ChIP_HESCs_Human0.91993487
105NFE2_27457419_Chip-Seq_LIVER_Mouse0.91219039
106RBPJ_22232070_ChIP-Seq_NCS_Mouse0.90705975
107RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.90513995
108CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.89892920
109* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.89499386
110MYB_26560356_Chip-Seq_TH1_Human0.89498408
111GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.88534145
112* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.88124458
113YY1_21170310_ChIP-Seq_MESCs_Mouse0.88028784
114MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.87389209
115TCF3_18692474_ChIP-Seq_MEFs_Mouse0.86521317
116HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.86303246
117* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.86151555
118DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.85282368
119STAT4_19710469_ChIP-ChIP_TH1__Mouse0.85243689
120* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.84592822
121* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.83879763
122MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.83574836
123SUZ12_27294783_Chip-Seq_NPCs_Mouse0.83565442
124CBP_20019798_ChIP-Seq_JUKART_Human0.82824002
125IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.82824002
126CTBP2_25329375_ChIP-Seq_LNCAP_Human0.82119053
127SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.82047574
128* NANOG_16153702_ChIP-ChIP_HESCs_Human0.80976960
129* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.80090058
130CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.79507847
131SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.79407595
132GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.79283413
133TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.78749987
134NANOG_21062744_ChIP-ChIP_HESCs_Human0.78447463
135CRX_20693478_ChIP-Seq_RETINA_Mouse0.77927313
136KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.77567655
137TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.77349391
138TCF3_18692474_ChIP-Seq_MESCs_Mouse0.76838041
139SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.76327243
140CTBP1_25329375_ChIP-Seq_LNCAP_Human0.75816824
141MYB_21317192_ChIP-Seq_ERMYB_Mouse0.75171571
142IRF8_22096565_ChIP-ChIP_GC-B_Human0.75124879

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation4.50393643
2* MP0010094_abnormal_chromosome_stability4.40441303
3MP0008057_abnormal_DNA_replication4.27311073
4MP0003693_abnormal_embryo_hatching4.12588006
5MP0003111_abnormal_nucleus_morphology4.03676722
6* MP0003077_abnormal_cell_cycle3.57523744
7MP0004957_abnormal_blastocyst_morpholog3.53291587
8* MP0008058_abnormal_DNA_repair3.30811737
9MP0008007_abnormal_cellular_replicative2.71239299
10MP0005408_hypopigmentation2.57146727
11* MP0002396_abnormal_hematopoietic_system2.40503399
12MP0008877_abnormal_DNA_methylation2.30982670
13MP0010352_gastrointestinal_tract_polyps2.30371362
14MP0005171_absent_coat_pigmentation2.29636630
15MP0005076_abnormal_cell_differentiation2.22454951
16MP0002102_abnormal_ear_morphology2.15115009
17* MP0000350_abnormal_cell_proliferation2.12801774
18MP0002009_preneoplasia2.12706384
19MP0010307_abnormal_tumor_latency2.08593817
20MP0008932_abnormal_embryonic_tissue2.08477090
21MP0009697_abnormal_copulation2.00844927
22MP0003806_abnormal_nucleotide_metabolis2.00581425
23MP0002938_white_spotting1.95250189
24* MP0003718_maternal_effect1.93635654
25MP0000569_abnormal_digit_pigmentation1.90853671
26MP0004808_abnormal_hematopoietic_stem1.87257995
27* MP0001730_embryonic_growth_arrest1.85521063
28MP0000490_abnormal_crypts_of1.79588655
29MP0003786_premature_aging1.74368948
30MP0003123_paternal_imprinting1.73111226
31MP0004147_increased_porphyrin_level1.64606957
32MP0000015_abnormal_ear_pigmentation1.59594062
33MP0003890_abnormal_embryonic-extraembry1.52755570
34MP0005174_abnormal_tail_pigmentation1.52077903
35* MP0001672_abnormal_embryogenesis/_devel1.51842790
36* MP0005380_embryogenesis_phenotype1.51842790
37* MP0002019_abnormal_tumor_incidence1.49672149
38MP0003646_muscle_fatigue1.49494357
39MP0000371_diluted_coat_color1.44306827
40MP0003121_genomic_imprinting1.42171499
41MP0001697_abnormal_embryo_size1.41560172
42MP0004197_abnormal_fetal_growth/weight/1.40889389
43MP0003763_abnormal_thymus_physiology1.38764351
44MP0003984_embryonic_growth_retardation1.33706852
45MP0002088_abnormal_embryonic_growth/wei1.32850863
46MP0001324_abnormal_eye_pigmentation1.31536479
47MP0002398_abnormal_bone_marrow1.31480630
48MP0002085_abnormal_embryonic_tissue1.31027635
49MP0002084_abnormal_developmental_patter1.29750541
50* MP0002080_prenatal_lethality1.27858354
51MP0000703_abnormal_thymus_morphology1.26657352
52MP0001293_anophthalmia1.25733994
53* MP0000313_abnormal_cell_death1.25315932
54MP0002086_abnormal_extraembryonic_tissu1.23729036
55MP0006072_abnormal_retinal_apoptosis1.21771853
56MP0004381_abnormal_hair_follicle1.20692539
57MP0006292_abnormal_olfactory_placode1.17331387
58MP0005253_abnormal_eye_physiology1.15835596
59MP0008995_early_reproductive_senescence1.15236525
60MP0002210_abnormal_sex_determination1.13338812
61MP0003315_abnormal_perineum_morphology1.11611702
62MP0002722_abnormal_immune_system1.10866955
63MP0002095_abnormal_skin_pigmentation1.10392325
64MP0009333_abnormal_splenocyte_physiolog1.09934434
65MP0005397_hematopoietic_system_phenotyp1.08803370
66MP0001545_abnormal_hematopoietic_system1.08803370
67MP0005389_reproductive_system_phenotype1.08378341
68MP0000427_abnormal_hair_cycle1.07864147
69MP0001835_abnormal_antigen_presentation1.07459627
70MP0000689_abnormal_spleen_morphology1.06448430
71MP0010155_abnormal_intestine_physiology1.05589892
72MP0001800_abnormal_humoral_immune1.02946221
73MP0002638_abnormal_pupillary_reflex0.99689882
74MP0000858_altered_metastatic_potential0.99285674
75MP0003448_altered_tumor_morphology0.99030654
76MP0001879_abnormal_lymphatic_vessel0.94822306
77MP0006035_abnormal_mitochondrial_morpho0.94300177
78* MP0002429_abnormal_blood_cell0.94265963
79MP0002160_abnormal_reproductive_system0.94203401
80MP0003566_abnormal_cell_adhesion0.94151027
81MP0001145_abnormal_male_reproductive0.94123099
82MP0006036_abnormal_mitochondrial_physio0.93950098
83MP0000716_abnormal_immune_system0.93116118
84MP0002452_abnormal_antigen_presenting0.92504884
85MP0002405_respiratory_system_inflammati0.91814786
86MP0000383_abnormal_hair_follicle0.91609622
87MP0003300_gastrointestinal_ulcer0.90364325
88MP0010030_abnormal_orbit_morphology0.88932934
89MP0002006_tumorigenesis0.88592454
90MP0002420_abnormal_adaptive_immunity0.88167546
91MP0003195_calcinosis0.88030457
92MP0003436_decreased_susceptibility_to0.87519137
93MP0009703_decreased_birth_body0.86695559
94MP0002132_abnormal_respiratory_system0.86614737
95MP0003787_abnormal_imprinting0.86486437
96MP0001819_abnormal_immune_cell0.86441169
97MP0005645_abnormal_hypothalamus_physiol0.86074178
98MP0001929_abnormal_gametogenesis0.85005932
99MP0002111_abnormal_tail_morphology0.83643002
100MP0005551_abnormal_eye_electrophysiolog0.82831848
101MP0000733_abnormal_muscle_development0.82787424
102MP0001986_abnormal_taste_sensitivity0.82721907
103MP0002234_abnormal_pharynx_morphology0.82459445
104MP0003186_abnormal_redox_activity0.82361563
105MP0009672_abnormal_birth_weight0.81916155
106MP0001186_pigmentation_phenotype0.81672237
107MP0005621_abnormal_cell_physiology0.81451097
108MP0005671_abnormal_response_to0.80904354
109MP0001286_abnormal_eye_development0.79370349
110MP0003943_abnormal_hepatobiliary_system0.79029061
111MP0003698_abnormal_male_reproductive0.78890199
112MP0002723_abnormal_immune_serum0.78849484
113MP0002166_altered_tumor_susceptibility0.78716133
114MP0000653_abnormal_sex_gland0.77908566
115MP0003567_abnormal_fetal_cardiomyocyte0.77852182
116MP0005464_abnormal_platelet_physiology0.77668548
117MP0000537_abnormal_urethra_morphology0.76992528
118MP0001764_abnormal_homeostasis0.76678181
119MP0003705_abnormal_hypodermis_morpholog0.76578412
120MP0005075_abnormal_melanosome_morpholog0.76137224
121MP0010678_abnormal_skin_adnexa0.75542742
122MP0003937_abnormal_limbs/digits/tail_de0.75540895
123MP0005384_cellular_phenotype0.75015922
124MP0003941_abnormal_skin_development0.74185538
125MP0002877_abnormal_melanocyte_morpholog0.74077410
126MP0003136_yellow_coat_color0.73054022
127MP0004133_heterotaxia0.72467418
128MP0000358_abnormal_cell_content/0.70627460
129MP0001119_abnormal_female_reproductive0.70122478
130MP0005000_abnormal_immune_tolerance0.70069051
131MP0001919_abnormal_reproductive_system0.69422075
132MP0000647_abnormal_sebaceous_gland0.67942730
133MP0009053_abnormal_anal_canal0.67919239
134MP0001853_heart_inflammation0.67834252
135MP0009278_abnormal_bone_marrow0.67574457
136MP0002075_abnormal_coat/hair_pigmentati0.67334676
137MP0005023_abnormal_wound_healing0.66712166
138MP0002092_abnormal_eye_morphology0.65675428
139MP0005391_vision/eye_phenotype0.64439166
140MP0004043_abnormal_pH_regulation0.63257087
141MP0002090_abnormal_vision0.61820704
142MP0000631_abnormal_neuroendocrine_gland0.61318457
143MP0005647_abnormal_sex_gland0.61114720
144* MP0005395_other_phenotype0.58006924
145MP0003950_abnormal_plasma_membrane0.56648240
146* MP0003699_abnormal_female_reproductive0.55369368
147MP0003656_abnormal_erythrocyte_physiolo0.55185094

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.45962751
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.14731819
3Birth length less than 3rd percentile (HP:0003561)3.67120726
4Reticulocytopenia (HP:0001896)3.51701597
5Medulloblastoma (HP:0002885)3.41003718
6Selective tooth agenesis (HP:0001592)3.24878509
7Abnormality of chromosome stability (HP:0003220)3.22167489
8Colon cancer (HP:0003003)2.91638613
9Agnosia (HP:0010524)2.78224731
10Rhabdomyosarcoma (HP:0002859)2.77738960
11Volvulus (HP:0002580)2.77571809
12Pancreatic cysts (HP:0001737)2.76946253
13Ectopic kidney (HP:0000086)2.74449864
14Ependymoma (HP:0002888)2.74206470
15Meckel diverticulum (HP:0002245)2.73186831
16Basal cell carcinoma (HP:0002671)2.71619909
17Abnormality of the preputium (HP:0100587)2.70141410
18Myelodysplasia (HP:0002863)2.68396797
19Patellar aplasia (HP:0006443)2.66026558
20Aplasia/Hypoplasia of the uvula (HP:0010293)2.62371228
21Increased nuchal translucency (HP:0010880)2.57973697
22Abnormality of the ileum (HP:0001549)2.57950291
23Abnormal number of incisors (HP:0011064)2.51256392
24Aplasia/Hypoplasia of the fovea (HP:0008060)2.51162358
25Hypoplasia of the fovea (HP:0007750)2.51162358
2611 pairs of ribs (HP:0000878)2.49410227
27Abnormality of DNA repair (HP:0003254)2.41677343
28Aplasia/Hypoplasia of the patella (HP:0006498)2.41667315
29Duodenal stenosis (HP:0100867)2.39263625
30Small intestinal stenosis (HP:0012848)2.39263625
31Abnormality of the fovea (HP:0000493)2.38325717
32Sloping forehead (HP:0000340)2.36326999
33Abnormality of the labia minora (HP:0012880)2.34293005
34Neoplasm of the adrenal cortex (HP:0100641)2.33681146
35Abnormality of methionine metabolism (HP:0010901)2.31438384
36Pancreatic fibrosis (HP:0100732)2.30883399
37Breast hypoplasia (HP:0003187)2.27777898
38Absent radius (HP:0003974)2.26788620
39Absent thumb (HP:0009777)2.25067131
40Acute myeloid leukemia (HP:0004808)2.24885570
41Abnormality of the renal cortex (HP:0011035)2.24867597
42Aplasia/Hypoplasia of the macula (HP:0008059)2.24577005
43Proximal placement of thumb (HP:0009623)2.23527847
44Renal cortical cysts (HP:0000803)2.23246223
45Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.22830398
46Short 4th metacarpal (HP:0010044)2.22830398
47Pallor (HP:0000980)2.22825511
48Deviation of the thumb (HP:0009603)2.21286803
49Neoplasm of the oral cavity (HP:0100649)2.20904720
50Missing ribs (HP:0000921)2.18345904
51Abnormality of cells of the erythroid lineage (HP:0012130)2.18040723
52Amaurosis fugax (HP:0100576)2.17860561
53Abnormality of the fingertips (HP:0001211)2.15776537
54Duplicated collecting system (HP:0000081)2.14195734
55Impulsivity (HP:0100710)2.13719138
56Lymphoma (HP:0002665)2.13537718
57Tracheoesophageal fistula (HP:0002575)2.11518944
58Neoplasm of the pancreas (HP:0002894)2.11192643
59Neoplasm of striated muscle (HP:0009728)2.11071000
60Astigmatism (HP:0000483)2.09709149
61Congenital stationary night blindness (HP:0007642)2.09704747
62Molar tooth sign on MRI (HP:0002419)2.09585653
63Abnormality of midbrain morphology (HP:0002418)2.09585653
64Abnormal number of erythroid precursors (HP:0012131)2.09393476
65Aplasia involving forearm bones (HP:0009822)2.09303225
66Absent forearm bone (HP:0003953)2.09303225
67Prominent nose (HP:0000448)2.07486079
68Intestinal atresia (HP:0011100)2.05481289
69Thrombocytosis (HP:0001894)2.05330081
70Bone marrow hypocellularity (HP:0005528)2.04370274
71Abnormality of the carotid arteries (HP:0005344)2.02412767
72Aplasia/Hypoplasia affecting the retina (HP:0008061)2.02400169
73Oral leukoplakia (HP:0002745)2.01974431
74Abnormality of alanine metabolism (HP:0010916)2.01361139
75Hyperalaninemia (HP:0003348)2.01361139
76Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.01361139
77IgM deficiency (HP:0002850)2.01111029
78Abnormal lung lobation (HP:0002101)2.00424376
79Eczematoid dermatitis (HP:0000976)1.99539046
80Abnormality of aspartate family amino acid metabolism (HP:0010899)1.99327239
81Nephroblastoma (Wilms tumor) (HP:0002667)1.98759994
82Supernumerary spleens (HP:0009799)1.98307512
83T lymphocytopenia (HP:0005403)1.97539842
84Neoplasm of the colon (HP:0100273)1.96435132
85Nephronophthisis (HP:0000090)1.95961719
86Abnormality of the duodenum (HP:0002246)1.95839917
87Pancreatic islet-cell hyperplasia (HP:0004510)1.95549119
88Abnormality of the astrocytes (HP:0100707)1.95292653
89Astrocytoma (HP:0009592)1.95292653
90True hermaphroditism (HP:0010459)1.95163291
91Embryonal renal neoplasm (HP:0011794)1.94550541
92Abnormal auditory evoked potentials (HP:0006958)1.93741411
93Squamous cell carcinoma (HP:0002860)1.92638208
94Premature graying of hair (HP:0002216)1.90644649
95Patchy hypopigmentation of hair (HP:0011365)1.88622543
96Biliary tract neoplasm (HP:0100574)1.87338835
97Aplastic anemia (HP:0001915)1.87087716
98Abnormal biliary tract physiology (HP:0012439)1.86828467
99Bile duct proliferation (HP:0001408)1.86828467
100Dyschromatopsia (HP:0007641)1.85796250
101Abnormality of T cell number (HP:0011839)1.85519683
102Clubbing of toes (HP:0100760)1.84627995
103Glioma (HP:0009733)1.84624604
104Small hand (HP:0200055)1.84156314
105Median cleft lip (HP:0000161)1.83678931
106Supernumerary bones of the axial skeleton (HP:0009144)1.82595530
107Abnormality of the renal collecting system (HP:0004742)1.82429305
108Degeneration of anterior horn cells (HP:0002398)1.79756883
109Abnormality of the anterior horn cell (HP:0006802)1.79756883
110Supernumerary ribs (HP:0005815)1.78526102
111Neoplasm of the adrenal gland (HP:0100631)1.78331981
112Short thumb (HP:0009778)1.78133825
113Bifid tongue (HP:0010297)1.77833288
114Cellulitis (HP:0100658)1.76949457
115Acute lymphatic leukemia (HP:0006721)1.76809534
116Cleft eyelid (HP:0000625)1.75543814
117High pitched voice (HP:0001620)1.75496740
118Long eyelashes (HP:0000527)1.75200397
119Prominent metopic ridge (HP:0005487)1.75114960
120Cafe-au-lait spot (HP:0000957)1.74985522
121Increased CSF lactate (HP:0002490)1.74294862
122Abnormality of the renal medulla (HP:0100957)1.73891908
123Abnormality of B cell number (HP:0010975)1.72763954
124Optic nerve coloboma (HP:0000588)1.72461443
125Atresia of the external auditory canal (HP:0000413)1.72362348
126Pulmonary fibrosis (HP:0002206)1.71927678
127Embryonal neoplasm (HP:0002898)1.70440944
128Albinism (HP:0001022)1.70265451
129Arteriovenous malformation (HP:0100026)1.70105689
130Panhypogammaglobulinemia (HP:0003139)1.68285392
131Triphalangeal thumb (HP:0001199)1.67929617
132White forelock (HP:0002211)1.67464833
133Recurrent viral infections (HP:0004429)1.67361580
134B lymphocytopenia (HP:0010976)1.67205579
135Malignant gastrointestinal tract tumors (HP:0006749)1.67187285
136Gastrointestinal carcinoma (HP:0002672)1.67187285
137Cutaneous melanoma (HP:0012056)1.66651708
138Abnormality of abdominal situs (HP:0011620)1.66194007
139Abdominal situs inversus (HP:0003363)1.66194007
140Poikiloderma (HP:0001029)1.66074404
141Abnormality of pyrimidine metabolism (HP:0004353)1.65664627
142IgA deficiency (HP:0002720)1.64699189
143Abnormality of homocysteine metabolism (HP:0010919)1.64615660
144Homocystinuria (HP:0002156)1.64615660
145Carpal bone hypoplasia (HP:0001498)1.64157128
146Gonadotropin excess (HP:0000837)1.63852584
147Decreased central vision (HP:0007663)1.62239462
148Dandy-Walker malformation (HP:0001305)1.61400770
149Central scotoma (HP:0000603)1.59442246
150Combined immunodeficiency (HP:0005387)1.59440142
151Blue irides (HP:0000635)1.58512734
152Facial cleft (HP:0002006)1.58512106
153Limb hypertonia (HP:0002509)1.57737606

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.01695156
2WEE13.58012407
3FRK3.31275034
4BUB13.09407599
5CDK122.86238947
6NEK22.82499028
7PASK2.68032999
8SRPK12.34071776
9TTK2.33760002
10EIF2AK12.21655610
11NUAK12.21642955
12MKNK12.12453580
13ATR2.05125306
14EEF2K2.02768775
15CDK71.99626033
16TSSK61.89214992
17PLK11.87653985
18BRSK21.86236063
19MKNK21.84095435
20MST41.77247821
21TLK11.75170011
22PLK41.74582928
23STK101.73525076
24TRIM281.73482943
25RPS6KB21.73056084
26AURKB1.71583488
27PNCK1.61630425
28CDK41.58708372
29ACVR1B1.53515536
30CHEK11.52106255
31WNK31.49169065
32CHEK21.46631098
33BRD41.46573999
34PDK21.45616677
35RPS6KA41.41674341
36PLK31.40682912
37MAP3K101.40130156
38STK41.35779022
39VRK21.35652098
40TNIK1.33895050
41ZAK1.31145487
42VRK11.30172349
43STK31.28351229
44TGFBR11.28009245
45DYRK31.27549189
46NEK11.25674197
47EPHA21.20091579
48* ATM1.19475551
49EIF2AK31.19360772
50MAP4K21.18880267
51SCYL21.18819025
52STK391.18571645
53MAP3K81.17187472
54CDK61.13892819
55MARK31.13495682
56BLK1.12760123
57TAF11.11076205
58TAOK31.05538014
59MAP4K11.04688655
60EIF2AK21.04222097
61PIM11.03540038
62PLK21.03406933
63ALK1.01264577
64WNK40.98838729
65CDK20.96702154
66MAP3K140.94039646
67AURKA0.91450423
68LATS10.90642709
69JAK30.90062218
70BRSK10.89327276
71PKN20.87771256
72YES10.79853527
73FLT30.79642731
74CDK10.79595020
75* CSNK2A20.74848076
76MELK0.73453229
77CDK90.73410027
78BMPR20.72783318
79LRRK20.72599116
80INSRR0.70687360
81NME20.70509860
82IKBKB0.67216701
83OXSR10.66345391
84TRPM70.64748227
85CDK30.64630858
86TESK20.61976138
87BTK0.61084423
88MTOR0.59419642
89TTN0.58000029
90PAK40.57609296
91KIT0.57397614
92CHUK0.57317032
93STK160.57126008
94FGFR20.55795527
95CCNB10.54885183
96PBK0.54850956
97IKBKE0.54755428
98STK240.53107964
99NLK0.52717404
100TEC0.52702310
101* PRKDC0.51727554
102* CSNK2A10.51624427
103STK38L0.50009876
104TYK20.49491540
105* CSNK1D0.48684101
106TXK0.48490925
107GRK10.46350525
108BMPR1B0.46032180
109CLK10.45290774
110RPS6KA50.45266647
111AKT30.45036012
112LCK0.43025893
113CDK80.42199393
114CSNK1G10.41219256
115IRAK40.41098752
116FGFR10.39132376
117ERBB30.38362062
118MAPK140.37156872
119NEK60.36899252
120CSK0.34947670
121AKT20.34603958
122AKT10.34375147
123PAK10.34071638
124MAPKAPK50.33774562
125NME10.33324353
126MAPK130.33235617
127LYN0.33216580
128CSNK1E0.32343958
129CSF1R0.31983431
130ZAP700.31752530
131MAPK10.31583805
132MAP3K40.28577858
133PINK10.26384638
134ADRBK20.26003438
135PRKACB0.23641251
136CSNK1A1L0.23259583
137CSNK1G30.23008068

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.74461169
2Mismatch repair_Homo sapiens_hsa034304.11392726
3* Homologous recombination_Homo sapiens_hsa034403.18469191
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.16514526
5Base excision repair_Homo sapiens_hsa034103.03966290
6RNA transport_Homo sapiens_hsa030132.78496851
7Spliceosome_Homo sapiens_hsa030402.78115691
8One carbon pool by folate_Homo sapiens_hsa006702.76956580
9Fanconi anemia pathway_Homo sapiens_hsa034602.68297100
10Cell cycle_Homo sapiens_hsa041102.67900150
11Nucleotide excision repair_Homo sapiens_hsa034202.57090545
12Protein export_Homo sapiens_hsa030602.33513337
13Ribosome_Homo sapiens_hsa030102.32177238
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.25110778
15* Non-homologous end-joining_Homo sapiens_hsa034502.06733392
16RNA polymerase_Homo sapiens_hsa030202.04858914
17RNA degradation_Homo sapiens_hsa030181.89211947
18Propanoate metabolism_Homo sapiens_hsa006401.84454442
19mRNA surveillance pathway_Homo sapiens_hsa030151.78130390
20Pyrimidine metabolism_Homo sapiens_hsa002401.75318041
21Proteasome_Homo sapiens_hsa030501.72795523
22Systemic lupus erythematosus_Homo sapiens_hsa053221.64739784
23p53 signaling pathway_Homo sapiens_hsa041151.61766209
24Basal transcription factors_Homo sapiens_hsa030221.57257183
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.54812605
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.34572486
27Viral carcinogenesis_Homo sapiens_hsa052031.30483536
28Antigen processing and presentation_Homo sapiens_hsa046121.28360877
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.26311917
30Epstein-Barr virus infection_Homo sapiens_hsa051691.25293791
31Herpes simplex infection_Homo sapiens_hsa051681.24306664
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.23778710
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.18717756
34Primary immunodeficiency_Homo sapiens_hsa053401.12361134
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.11389174
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.08572381
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.07745863
38Small cell lung cancer_Homo sapiens_hsa052221.06353030
39NF-kappa B signaling pathway_Homo sapiens_hsa040641.05291507
40HTLV-I infection_Homo sapiens_hsa051661.02604862
41Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.00461466
42MicroRNAs in cancer_Homo sapiens_hsa052060.99759886
43Transcriptional misregulation in cancer_Homo sapiens_hsa052020.98628278
44Nitrogen metabolism_Homo sapiens_hsa009100.97901387
45Measles_Homo sapiens_hsa051620.96908324
46Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.94739750
47Oxidative phosphorylation_Homo sapiens_hsa001900.94314011
48Parkinsons disease_Homo sapiens_hsa050120.92509921
49Legionellosis_Homo sapiens_hsa051340.90694700
50Purine metabolism_Homo sapiens_hsa002300.90494743
51Chronic myeloid leukemia_Homo sapiens_hsa052200.86776655
52Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.86483274
53Butanoate metabolism_Homo sapiens_hsa006500.85360141
54Apoptosis_Homo sapiens_hsa042100.83844970
55Pyruvate metabolism_Homo sapiens_hsa006200.82496063
56Huntingtons disease_Homo sapiens_hsa050160.78801445
57Hepatitis B_Homo sapiens_hsa051610.76966273
58Colorectal cancer_Homo sapiens_hsa052100.74369351
59Phototransduction_Homo sapiens_hsa047440.73666740
60Leishmaniasis_Homo sapiens_hsa051400.73076568
61NOD-like receptor signaling pathway_Homo sapiens_hsa046210.72517926
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71478921
63Oocyte meiosis_Homo sapiens_hsa041140.70519732
64Influenza A_Homo sapiens_hsa051640.69538871
65Hematopoietic cell lineage_Homo sapiens_hsa046400.67859438
66Acute myeloid leukemia_Homo sapiens_hsa052210.66784688
67Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.66556389
68B cell receptor signaling pathway_Homo sapiens_hsa046620.66065838
69Alcoholism_Homo sapiens_hsa050340.62290036
70Lysine degradation_Homo sapiens_hsa003100.60904595
71Thyroid cancer_Homo sapiens_hsa052160.60832733
72Prostate cancer_Homo sapiens_hsa052150.60442355
73Intestinal immune network for IgA production_Homo sapiens_hsa046720.60377026
74Maturity onset diabetes of the young_Homo sapiens_hsa049500.59813104
75Folate biosynthesis_Homo sapiens_hsa007900.57566116
76Selenocompound metabolism_Homo sapiens_hsa004500.57254324
77Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.56212857
78RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.55868839
79Viral myocarditis_Homo sapiens_hsa054160.55587762
80Basal cell carcinoma_Homo sapiens_hsa052170.55492987
81Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.54485652
82Tryptophan metabolism_Homo sapiens_hsa003800.54334322
83T cell receptor signaling pathway_Homo sapiens_hsa046600.53998751
84Steroid biosynthesis_Homo sapiens_hsa001000.53841323
85TGF-beta signaling pathway_Homo sapiens_hsa043500.53381400
86Non-small cell lung cancer_Homo sapiens_hsa052230.52671897
87Osteoclast differentiation_Homo sapiens_hsa043800.52390187
88Fatty acid elongation_Homo sapiens_hsa000620.52088126
89Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.51586105
90Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.50591570
91TNF signaling pathway_Homo sapiens_hsa046680.50523533
92Leukocyte transendothelial migration_Homo sapiens_hsa046700.50012344
93Hippo signaling pathway_Homo sapiens_hsa043900.49043951
94Adherens junction_Homo sapiens_hsa045200.48895475
95Metabolic pathways_Homo sapiens_hsa011000.48311069
96Pancreatic cancer_Homo sapiens_hsa052120.47407284
97Jak-STAT signaling pathway_Homo sapiens_hsa046300.47208715
98Toxoplasmosis_Homo sapiens_hsa051450.47041288
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.45274380
100Peroxisome_Homo sapiens_hsa041460.45064695
101Pentose phosphate pathway_Homo sapiens_hsa000300.44724948
102Toll-like receptor signaling pathway_Homo sapiens_hsa046200.44624947
103Glutathione metabolism_Homo sapiens_hsa004800.44430199
104Pathways in cancer_Homo sapiens_hsa052000.43745453
105Shigellosis_Homo sapiens_hsa051310.43661880
106Regulation of autophagy_Homo sapiens_hsa041400.43007561
107N-Glycan biosynthesis_Homo sapiens_hsa005100.42407328
108Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42324006
109Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.40880460
110Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.40505500
111Fatty acid metabolism_Homo sapiens_hsa012120.40348682
112Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.39600198
113HIF-1 signaling pathway_Homo sapiens_hsa040660.38640434
114Bladder cancer_Homo sapiens_hsa052190.38410531
115mTOR signaling pathway_Homo sapiens_hsa041500.37289290
116Allograft rejection_Homo sapiens_hsa053300.37217008
117Endometrial cancer_Homo sapiens_hsa052130.36679381
118Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.36643274
119Melanoma_Homo sapiens_hsa052180.36068524
120Caffeine metabolism_Homo sapiens_hsa002320.35387861
121Graft-versus-host disease_Homo sapiens_hsa053320.35033440
122Drug metabolism - other enzymes_Homo sapiens_hsa009830.34655279
123AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.34296372
124Proteoglycans in cancer_Homo sapiens_hsa052050.34129099
125Notch signaling pathway_Homo sapiens_hsa043300.33659441
126Ether lipid metabolism_Homo sapiens_hsa005650.33250642
127Asthma_Homo sapiens_hsa053100.32738775
128Olfactory transduction_Homo sapiens_hsa047400.32199007
129Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.31692750
130Alzheimers disease_Homo sapiens_hsa050100.31195440
131FoxO signaling pathway_Homo sapiens_hsa040680.29370129
132Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.28933872
133Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.28624993
134Renin-angiotensin system_Homo sapiens_hsa046140.28098590
135beta-Alanine metabolism_Homo sapiens_hsa004100.26740175
136Pentose and glucuronate interconversions_Homo sapiens_hsa000400.26225197
137Hedgehog signaling pathway_Homo sapiens_hsa043400.25877116
138Fatty acid degradation_Homo sapiens_hsa000710.25564306
139Linoleic acid metabolism_Homo sapiens_hsa005910.25376297
140Thyroid hormone signaling pathway_Homo sapiens_hsa049190.23181490
141Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.22620709
142PI3K-Akt signaling pathway_Homo sapiens_hsa041510.22296692
143Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.21708664
144Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.20770669
145Carbon metabolism_Homo sapiens_hsa012000.17811332
146Glycerolipid metabolism_Homo sapiens_hsa005610.15977517
147Primary bile acid biosynthesis_Homo sapiens_hsa001200.14826151
148Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.14265069
149Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.13684259
150Circadian rhythm_Homo sapiens_hsa047100.13661227
151SNARE interactions in vesicular transport_Homo sapiens_hsa041300.13198620
152Retinol metabolism_Homo sapiens_hsa008300.12346321

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