MPZL3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)8.41989772
2establishment of skin barrier (GO:0061436)7.79375191
3regulation of water loss via skin (GO:0033561)7.42984455
4keratinization (GO:0031424)6.31180435
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.18762606
6negative regulation of cell killing (GO:0031342)6.18762606
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.68035643
8cellular response to interleukin-15 (GO:0071350)5.44279887
9bundle of His cell to Purkinje myocyte communication (GO:0086069)5.35708132
10positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.25247893
11hemidesmosome assembly (GO:0031581)5.20724022
12detection of bacterium (GO:0016045)5.10602598
13response to interleukin-15 (GO:0070672)5.00236243
14multicellular organismal water homeostasis (GO:0050891)4.96145477
15positive regulation of gamma-delta T cell activation (GO:0046645)4.78571318
16regulation of B cell receptor signaling pathway (GO:0050855)4.73298241
17keratinocyte differentiation (GO:0030216)4.70006781
18interferon-gamma secretion (GO:0072643)4.60383421
19tolerance induction (GO:0002507)4.55312818
20detection of other organism (GO:0098543)4.42748422
21negative T cell selection (GO:0043383)4.42627074
22water homeostasis (GO:0030104)4.42622898
23negative regulation of T cell mediated immunity (GO:0002710)4.40040154
24skin morphogenesis (GO:0043589)4.32814470
25negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)4.22433479
26keratinocyte proliferation (GO:0043616)4.10146835
27negative regulation of lymphocyte mediated immunity (GO:0002707)4.05526575
28regulation of regulatory T cell differentiation (GO:0045589)4.05322954
29regulation of gamma-delta T cell activation (GO:0046643)4.05026551
30regulation of T cell mediated cytotoxicity (GO:0001914)4.01917831
31negative thymic T cell selection (GO:0045060)3.99204973
32regulation of natural killer cell differentiation (GO:0032823)3.95066343
33negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.93522009
34negative regulation of T-helper cell differentiation (GO:0045623)3.93522009
35neutrophil activation involved in immune response (GO:0002283)3.90923892
36positive regulation of T cell mediated cytotoxicity (GO:0001916)3.89676324
37dendritic cell migration (GO:0036336)3.85894249
38phospholipid efflux (GO:0033700)3.85410822
39sphingoid metabolic process (GO:0046519)3.81537166
40neutrophil activation (GO:0042119)3.73085436
41sphingosine metabolic process (GO:0006670)3.71517078
42regulation of memory T cell differentiation (GO:0043380)3.70169679
43peptide cross-linking (GO:0018149)3.67183373
44interferon-gamma production (GO:0032609)3.65683479
45regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.64078540
46epidermal cell differentiation (GO:0009913)3.63861429
47regulation of leukocyte mediated cytotoxicity (GO:0001910)3.63052852
48regulation of alpha-beta T cell proliferation (GO:0046640)3.61547526
49negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.58878460
50negative regulation of adaptive immune response (GO:0002820)3.58506282
51regulation of cholesterol homeostasis (GO:2000188)3.58212417
52intestinal epithelial cell development (GO:0060576)3.57799895
53positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.57081671
54primary alcohol catabolic process (GO:0034310)3.54839918
55leukocyte aggregation (GO:0070486)3.54646367
56regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.49413369
57regulation of natural killer cell mediated immunity (GO:0002715)3.49413369
58L-phenylalanine catabolic process (GO:0006559)3.46562636
59erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.46562636
60regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.44334159
61positive regulation by symbiont of host defense response (GO:0052509)3.43610368
62modulation by symbiont of host defense response (GO:0052031)3.43610368
63modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.43610368
64modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.43610368
65positive regulation by organism of defense response of other organism involved in symbiotic interact3.43610368
66modulation by symbiont of host immune response (GO:0052553)3.43610368
67diol metabolic process (GO:0034311)3.42610216
68regulation of transforming growth factor beta1 production (GO:0032908)3.41527831
69positive regulation of alpha-beta T cell proliferation (GO:0046641)3.41365978
70dendritic cell chemotaxis (GO:0002407)3.40989727
71regulation of triglyceride catabolic process (GO:0010896)3.37603661
72* molting cycle (GO:0042303)3.37004067
73* hair cycle (GO:0042633)3.37004067
74erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.32514305
75L-phenylalanine metabolic process (GO:0006558)3.32514305
76kynurenine metabolic process (GO:0070189)3.31485702
77positive regulation of interleukin-8 secretion (GO:2000484)3.31405683
78DNA deamination (GO:0045006)3.30880184
79negative regulation of leukocyte mediated immunity (GO:0002704)3.28845172
80ethanol metabolic process (GO:0006067)3.27248440
81granulocyte activation (GO:0036230)3.26820327
82T-helper cell differentiation (GO:0042093)3.26514484
83CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.26514484
84urea cycle (GO:0000050)3.26061437
85urea metabolic process (GO:0019627)3.26061437
86regulation of cell killing (GO:0031341)3.24925667
87regulation of T cell receptor signaling pathway (GO:0050856)3.24889025
88mast cell activation (GO:0045576)3.24530399
89aromatic amino acid family catabolic process (GO:0009074)3.21335747
90activated T cell proliferation (GO:0050798)3.19373095
91positive regulation of humoral immune response (GO:0002922)3.19079603
92positive regulation of cell killing (GO:0031343)3.16830036
93positive regulation of natural killer cell mediated immunity (GO:0002717)3.16441035
94epidermis development (GO:0008544)3.16347661
95antigen processing and presentation via MHC class Ib (GO:0002475)3.14990939
96sulfur amino acid catabolic process (GO:0000098)3.14897658
97cellular extravasation (GO:0045123)3.13431495
98positive T cell selection (GO:0043368)3.12893577
99negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.12823208
100triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.12265365
101cytidine metabolic process (GO:0046087)3.11920694
102cytidine catabolic process (GO:0006216)3.11920694
103cytidine deamination (GO:0009972)3.11920694
104regulation of interleukin-8 secretion (GO:2000482)3.09258921
105negative regulation of interleukin-12 production (GO:0032695)3.08960219
106alpha-beta T cell differentiation (GO:0046632)3.08430122
107indole-containing compound catabolic process (GO:0042436)3.06840295
108indolalkylamine catabolic process (GO:0046218)3.06840295
109tryptophan catabolic process (GO:0006569)3.06840295
110fibrinolysis (GO:0042730)3.06626395
111antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.05663035
112antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.05663035
113ectoderm development (GO:0007398)3.04086192
114intestinal cholesterol absorption (GO:0030299)3.03723854
115macrophage activation involved in immune response (GO:0002281)3.02540410
116high-density lipoprotein particle remodeling (GO:0034375)3.01545688
117intermediate filament organization (GO:0045109)2.98862503
118alpha-beta T cell activation (GO:0046631)2.97925942
119T cell selection (GO:0045058)2.97194566
120negative regulation of sterol transport (GO:0032372)2.97118641
121negative regulation of cholesterol transport (GO:0032375)2.97118641
122cysteine metabolic process (GO:0006534)2.96352754
123detection of external biotic stimulus (GO:0098581)2.94690073
124neutrophil mediated immunity (GO:0002446)2.93923740
125regulation of protein activation cascade (GO:2000257)2.93664053
126regulation of T cell mediated immunity (GO:0002709)2.92612750
127fatty acid elongation (GO:0030497)2.92602200
128alpha-beta T cell differentiation involved in immune response (GO:0002293)2.91482072
129alpha-beta T cell activation involved in immune response (GO:0002287)2.91482072
130T cell differentiation involved in immune response (GO:0002292)2.91482072
131leukocyte degranulation (GO:0043299)2.90183309
132cellular defense response (GO:0006968)2.89111368
133regulation of interferon-beta biosynthetic process (GO:0045357)2.88211083
134bile acid biosynthetic process (GO:0006699)2.87714329
135negative regulation of B cell activation (GO:0050869)2.87380628
136nitrogen cycle metabolic process (GO:0071941)2.87277355
137linoleic acid metabolic process (GO:0043651)2.87105120
138regulation of B cell differentiation (GO:0045577)2.86578313
139positive regulation of cellular amide metabolic process (GO:0034250)2.86374849
140hormone catabolic process (GO:0042447)2.86159323
141positive regulation of tolerance induction (GO:0002645)2.84768420
142positive regulation of mRNA catabolic process (GO:0061014)2.82130886
143regulation of phospholipase A2 activity (GO:0032429)2.82020198
144negative regulation of lipase activity (GO:0060192)2.81673791
145pyrimidine ribonucleoside catabolic process (GO:0046133)2.81142340
146complement activation, alternative pathway (GO:0006957)2.80978897
147detection of molecule of bacterial origin (GO:0032490)2.80836861
148positive regulation of T cell mediated immunity (GO:0002711)2.80629952
149CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.80551311
150protein carboxylation (GO:0018214)2.79978835
151peptidyl-glutamic acid carboxylation (GO:0017187)2.79978835
152microglial cell activation (GO:0001774)2.79910028
153tryptophan metabolic process (GO:0006568)2.79879107
154positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.79830721
155negative regulation of fibrinolysis (GO:0051918)2.79596206
156regulation of complement activation (GO:0030449)2.77725475
157positive regulation of granulocyte differentiation (GO:0030854)2.77557046
158retinal metabolic process (GO:0042574)2.76893935
159amino-acid betaine metabolic process (GO:0006577)2.76836521
160myeloid cell activation involved in immune response (GO:0002275)2.76602054
161regulation of germinal center formation (GO:0002634)2.76259896
162bile acid and bile salt transport (GO:0015721)2.76251271
163production of molecular mediator involved in inflammatory response (GO:0002532)2.75974344
164regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.75306244
165positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.75306244
166antigen processing and presentation of endogenous antigen (GO:0019883)2.73866156
167acylglycerol homeostasis (GO:0055090)2.73798218
168triglyceride homeostasis (GO:0070328)2.73798218
169regulation of fibrinolysis (GO:0051917)2.70968578
170hepatocyte apoptotic process (GO:0097284)2.70131564
171regulation of ruffle assembly (GO:1900027)2.70112947
172homocysteine metabolic process (GO:0050667)2.70020702
173reverse cholesterol transport (GO:0043691)2.64740722
174imidazole-containing compound metabolic process (GO:0052803)2.60706131
175positive regulation of lipoprotein lipase activity (GO:0051006)2.60610908
176positive regulation of triglyceride lipase activity (GO:0061365)2.60610908
177bile acid metabolic process (GO:0008206)2.59897877
178intestinal absorption (GO:0050892)2.54701112
179alpha-linolenic acid metabolic process (GO:0036109)2.53481707
180atrioventricular valve morphogenesis (GO:0003181)2.50577364
181acute-phase response (GO:0006953)2.49975189
182positive regulation of fatty acid biosynthetic process (GO:0045723)2.49491230
183response to phenylpropanoid (GO:0080184)2.49080404
184defense response to fungus (GO:0050832)2.48327664
185regulation of gamma-delta T cell differentiation (GO:0045586)2.45974204
186positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.43714794
187fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.42294094
188positive regulation of lipid catabolic process (GO:0050996)2.41974655
189macromolecular complex remodeling (GO:0034367)2.40207948
190plasma lipoprotein particle remodeling (GO:0034369)2.40207948
191protein-lipid complex remodeling (GO:0034368)2.40207948
192fat-soluble vitamin biosynthetic process (GO:0042362)2.39639364

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.98664168
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.78810618
3RXR_22158963_ChIP-Seq_LIVER_Mouse3.52265382
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.50781702
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.23184868
6LXR_22158963_ChIP-Seq_LIVER_Mouse2.98592067
7ESR1_21235772_ChIP-Seq_MCF-7_Human2.80833424
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.76635384
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.71014947
10ESR2_21235772_ChIP-Seq_MCF-7_Human2.57134529
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.54839999
12EGR1_23403033_ChIP-Seq_LIVER_Mouse2.50899219
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.49991416
14SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.37824634
15NOTCH1_21737748_ChIP-Seq_TLL_Human2.34327261
16IRF8_27001747_Chip-Seq_BMDM_Mouse2.33675747
17SMAD_19615063_ChIP-ChIP_OVARY_Human2.31529033
18SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.26797413
19P63_26484246_Chip-Seq_KERATINOCYTES_Human2.21054741
20GATA3_26560356_Chip-Seq_TH2_Human2.20219277
21BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.17997798
22GATA3_27048872_Chip-Seq_THYMUS_Human2.14570376
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.06723815
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.05997091
25ZNF263_19887448_ChIP-Seq_K562_Human2.05712247
26NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.05588389
27* FOXO3_23340844_ChIP-Seq_DLD1_Human2.00231583
28TP63_17297297_ChIP-ChIP_HaCaT_Human10.8348082
29PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.99211482
30STAT4_19710469_ChIP-ChIP_TH1__Mouse1.98032459
31SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.93613911
32SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.93613911
33RARG_19884340_ChIP-ChIP_MEFs_Mouse1.90599816
34SOX9_24532713_ChIP-Seq_HFSC_Mouse1.88550270
35* MYB_26560356_Chip-Seq_TH1_Human1.88352743
36SOX2_27498859_Chip-Seq_STOMACH_Mouse1.84759220
37FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.84070266
38GATA4_25053715_ChIP-Seq_YYC3_Human1.81444582
39SPI1_23547873_ChIP-Seq_NB4_Human1.80443527
40CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.76838695
41TRIM28_21343339_ChIP-Seq_HEK293_Human1.76500098
42RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.72354575
43SOX2_20726797_ChIP-Seq_SW620_Human1.70323525
44SCL_19346495_ChIP-Seq_HPC-7_Human1.69765602
45* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.66054164
46SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.63517024
47PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.61439892
48BP1_19119308_ChIP-ChIP_Hs578T_Human1.59201561
49CLOCK_20551151_ChIP-Seq_293T_Human1.58377408
50KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.54215977
51IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.52019958
52STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.50556498
53CDX2_20551321_ChIP-Seq_CACO-2_Human1.49193449
54GATA6_25053715_ChIP-Seq_YYC3_Human1.49116603
55PPAR_26484153_Chip-Seq_NCI-H1993_Human1.48875258
56ZNF217_24962896_ChIP-Seq_MCF-7_Human1.47991197
57RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.47697244
58HIF1A_21447827_ChIP-Seq_MCF-7_Human1.45519452
59RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.45459767
60RUNX1_27514584_Chip-Seq_MCF-7_Human1.42278967
61VDR_24787735_ChIP-Seq_THP-1_Human1.41501735
62VDR_22108803_ChIP-Seq_LS180_Human1.39235402
63ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.39012990
64RACK7_27058665_Chip-Seq_MCF-7_Human1.37447947
65KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.36602267
66ATF3_27146783_Chip-Seq_COLON_Human1.34903095
67LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.33831556
68* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.33777529
69ELF1_17652178_ChIP-ChIP_JURKAT_Human1.33204018
70TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.33086024
71ESR1_20079471_ChIP-ChIP_T-47D_Human1.29584595
72FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.29357433
73STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.25161517
74E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.24940777
75GATA3_24758297_ChIP-Seq_MCF-7_Human1.23915351
76PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.21924382
77RUNX1_22412390_ChIP-Seq_EML_Mouse1.21258940
78LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.19723529
79SPI1_23127762_ChIP-Seq_K562_Human1.18275170
80CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.17118025
81ER_23166858_ChIP-Seq_MCF-7_Human1.17024786
82PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13517109
83STAT6_21828071_ChIP-Seq_BEAS2B_Human1.12960409
84SMRT_27268052_Chip-Seq_Bcells_Human1.12741647
85FLI1_27457419_Chip-Seq_LIVER_Mouse1.11729509
86TP63_23658742_ChIP-Seq_EP156T_Human1.11077483
87TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.07651703
88KLF5_25053715_ChIP-Seq_YYC3_Human1.07024841
89GATA3_26560356_Chip-Seq_TH1_Human1.06723630
90CJUN_26792858_Chip-Seq_BT549_Human1.06334148
91MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.05557336
92HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.01861806
93SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.01699537
94TCF4_18268006_ChIP-ChIP_LS174T_Human1.01140349
95CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.00585013
96PU_27001747_Chip-Seq_BMDM_Mouse1.00075041
97GATA1_22025678_ChIP-Seq_K562_Human0.99631151
98IRF8_22096565_ChIP-ChIP_GC-B_Human0.99593078
99POU3F2_20337985_ChIP-ChIP_501MEL_Human0.99051736
100CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.98826837
101RUNX_20019798_ChIP-Seq_JUKART_Human0.98732158
102GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.98659061
103Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.96046524
104TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95379216
105* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.94700756
106EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.94695084
107SUZ12_27294783_Chip-Seq_NPCs_Mouse0.94592003
108FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.93609035
109CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92712204
110GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.92701555
111* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92341579
112LXR_22292898_ChIP-Seq_THP-1_Human0.92083832
113CDX2_22108803_ChIP-Seq_LS180_Human0.92078338
114NFE2_27457419_Chip-Seq_LIVER_Mouse0.91611713
115GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91305511
116ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.90794379
117BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.90766682
118VDR_24763502_ChIP-Seq_THP-1_Human0.90014015
119ARNT_22903824_ChIP-Seq_MCF-7_Human0.89877191
120* FOXA2_19822575_ChIP-Seq_HepG2_Human0.89765924
121CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89440689
122EGR1_19032775_ChIP-ChIP_M12_Human0.89136646
123EZH2_27294783_Chip-Seq_NPCs_Mouse0.87692051
124SALL4_22934838_ChIP-ChIP_CD34+_Human0.87686674
125CEBPB_22108803_ChIP-Seq_LS180_Human0.87552165
126SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.87430972
127ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87229231
128TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.87004003
129RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.86645034
130PCGF2_27294783_Chip-Seq_ESCs_Mouse0.86563145
131PRDM14_20953172_ChIP-Seq_ESCs_Human0.86447219
132AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.85844526
133* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85706961
134CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85084616
135GATA2_22383799_ChIP-Seq_G1ME_Mouse0.83610241
136TP63_22573176_ChIP-Seq_HFKS_Human0.83122277
137UBF1/2_26484160_Chip-Seq_HMECs_Human0.82518596
138CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.81980458
139MYB_26560356_Chip-Seq_TH2_Human0.81374887
140ZNF274_21170338_ChIP-Seq_K562_Hela0.80813324
141TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.80665684
142CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.80027883
143RXR_22108803_ChIP-Seq_LS180_Human0.78305935
144TAF15_26573619_Chip-Seq_HEK293_Human0.78182880
145* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.77958931
146VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.76724098
147* FOXA1_25552417_ChIP-Seq_VCAP_Human0.76615391
148AHR_22903824_ChIP-Seq_MCF-7_Human0.76575716
149BCAT_22108803_ChIP-Seq_LS180_Human0.76118770
150MAF_26560356_Chip-Seq_TH1_Human0.73858755
151GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.72642127
152NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.71113549
153BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.70552707
154TP53_18474530_ChIP-ChIP_U2OS_Human0.70033510
155GATA2_21666600_ChIP-Seq_HMVEC_Human0.69373350
156BRD4_27068464_Chip-Seq_AML-cells_Mouse0.68828273
157NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.68420262
158TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.67430092
159UTX_26944678_Chip-Seq_JUKART_Human0.65898803
160MYB_21317192_ChIP-Seq_ERMYB_Mouse0.64109164
161SALL4_18804426_ChIP-ChIP_XEN_Mouse0.63965183
162* GATA2_19941826_ChIP-Seq_K562_Human0.62641861

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier5.85493019
2MP0010234_abnormal_vibrissa_follicle5.70639713
3MP0005501_abnormal_skin_physiology3.63238091
4MP0001835_abnormal_antigen_presentation3.48206274
5MP0005275_abnormal_skin_tensile3.43735130
6MP0005451_abnormal_body_composition3.34277285
7MP0002139_abnormal_hepatobiliary_system3.09878705
8MP0005360_urolithiasis3.09150214
9MP0003453_abnormal_keratinocyte_physiol2.88215660
10MP0005085_abnormal_gallbladder_physiolo2.86663961
11MP0005000_abnormal_immune_tolerance2.81740455
12MP0002254_reproductive_system_inflammat2.76579309
13* MP0001216_abnormal_epidermal_layer2.69860246
14* MP0004947_skin_inflammation2.65029983
15MP0003941_abnormal_skin_development2.64217252
16MP0010678_abnormal_skin_adnexa2.51507269
17* MP0002060_abnormal_skin_morphology2.48781403
18MP0005365_abnormal_bile_salt2.47321770
19MP0000579_abnormal_nail_morphology2.35874444
20MP0002419_abnormal_innate_immunity2.29425988
21MP0002420_abnormal_adaptive_immunity2.28221225
22MP0001819_abnormal_immune_cell2.25903260
23MP0002452_abnormal_antigen_presenting2.25186838
24MP0002277_abnormal_respiratory_mucosa2.21922239
25MP0008875_abnormal_xenobiotic_pharmacok2.11798696
26MP0002098_abnormal_vibrissa_morphology2.10370331
27MP0001666_abnormal_nutrient_absorption2.08936336
28* MP0010771_integument_phenotype2.05583263
29MP0003705_abnormal_hypodermis_morpholog2.01523016
30* MP0004381_abnormal_hair_follicle1.98594236
31MP0003191_abnormal_cellular_cholesterol1.97718317
32MP0000383_abnormal_hair_follicle1.94170322
33MP0000647_abnormal_sebaceous_gland1.88422103
34MP0006082_CNS_inflammation1.85886389
35* MP0000377_abnormal_hair_follicle1.79545762
36* MP0002398_abnormal_bone_marrow1.78452834
37MP0004264_abnormal_extraembryonic_tissu1.76893977
38MP0000716_abnormal_immune_system1.71266701
39MP0003252_abnormal_bile_duct1.70638562
40MP0003566_abnormal_cell_adhesion1.66559605
41MP0003303_peritoneal_inflammation1.65482516
42MP0003300_gastrointestinal_ulcer1.63972427
43MP0002132_abnormal_respiratory_system1.61073842
44MP0003436_decreased_susceptibility_to1.59552951
45* MP0000689_abnormal_spleen_morphology1.58950454
46MP0000569_abnormal_digit_pigmentation1.55718002
47MP0005310_abnormal_salivary_gland1.54934715
48MP0005464_abnormal_platelet_physiology1.53440337
49MP0005075_abnormal_melanosome_morpholog1.52719106
50MP0000703_abnormal_thymus_morphology1.50419738
51MP0002722_abnormal_immune_system1.46697456
52MP0002163_abnormal_gland_morphology1.45278535
53MP0010329_abnormal_lipoprotein_level1.43930570
54MP0002876_abnormal_thyroid_physiology1.43677403
55MP0000467_abnormal_esophagus_morphology1.43013716
56MP0004185_abnormal_adipocyte_glucose1.40609476
57MP0001191_abnormal_skin_condition1.39580699
58MP0003763_abnormal_thymus_physiology1.35524471
59* MP0009931_abnormal_skin_appearance1.34616929
60MP0010155_abnormal_intestine_physiology1.34564700
61MP0010352_gastrointestinal_tract_polyps1.33577623
62MP0002138_abnormal_hepatobiliary_system1.32925680
63* MP0000427_abnormal_hair_cycle1.30539730
64MP0002429_abnormal_blood_cell1.27984613
65MP0005023_abnormal_wound_healing1.27971949
66MP0004019_abnormal_vitamin_homeostasis1.27324849
67MP0003656_abnormal_erythrocyte_physiolo1.25200992
68MP0003806_abnormal_nucleotide_metabolis1.24662638
69MP0002009_preneoplasia1.23976780
70MP0001873_stomach_inflammation1.19712931
71MP0003195_calcinosis1.18475830
72MP0005083_abnormal_biliary_tract1.18350176
73MP0000685_abnormal_immune_system1.17264494
74MP0001851_eye_inflammation1.16608704
75* MP0000609_abnormal_liver_physiology1.14777175
76MP0002166_altered_tumor_susceptibility1.12615562
77MP0009840_abnormal_foam_cell1.11485240
78MP0003828_pulmonary_edema1.11373069
79MP0009764_decreased_sensitivity_to1.11153491
80MP0001919_abnormal_reproductive_system1.09884154
81* MP0000367_abnormal_coat/_hair1.07315639
82* MP0001243_abnormal_dermal_layer1.03650634
83MP0008877_abnormal_DNA_methylation1.03437320
84MP0003866_abnormal_defecation1.03060728
85MP0004782_abnormal_surfactant_physiolog1.02391667
86MP0003045_fibrosis1.01876068
87MP0008872_abnormal_physiological_respon0.99740843
88MP0005379_endocrine/exocrine_gland_phen0.99240862
89MP0003787_abnormal_imprinting0.96235053
90MP0002693_abnormal_pancreas_physiology0.94809619
91MP0001881_abnormal_mammary_gland0.94334327
92MP0000627_abnormal_mammary_gland0.93399514
93MP0005174_abnormal_tail_pigmentation0.92059023
94MP0009785_altered_susceptibility_to0.91284453
95MP0000537_abnormal_urethra_morphology0.88510043
96MP0002118_abnormal_lipid_homeostasis0.88204310
97MP0000015_abnormal_ear_pigmentation0.87833195
98MP0004883_abnormal_blood_vessel0.87691934
99MP0002006_tumorigenesis0.87138965
100MP0003183_abnormal_peptide_metabolism0.86650071
101MP0001853_heart_inflammation0.85755390
102MP0002396_abnormal_hematopoietic_system0.85188835
103MP0005076_abnormal_cell_differentiation0.85086582
104MP0004484_altered_response_of0.84629744
105MP0003638_abnormal_response/metabolism_0.83692053
106MP0000604_amyloidosis0.83314924
107MP0002998_abnormal_bone_remodeling0.82593882
108MP0000465_gastrointestinal_hemorrhage0.82341296
109MP0000566_synostosis0.81574820
110MP0000762_abnormal_tongue_morphology0.81490671
111MP0005332_abnormal_amino_acid0.78478294
112MP0001800_abnormal_humoral_immune0.77770334
113MP0009763_increased_sensitivity_to0.76814229
114MP0001501_abnormal_sleep_pattern0.76775014
115MP0009384_cardiac_valve_regurgitation0.76406704
116MP0000858_altered_metastatic_potential0.75515151
117MP0003172_abnormal_lysosome_physiology0.75332797
118MP0008260_abnormal_autophagy0.74404062
119MP0003878_abnormal_ear_physiology0.73674594
120MP0005377_hearing/vestibular/ear_phenot0.73674594
121MP0009053_abnormal_anal_canal0.73479443
122* MP0001845_abnormal_inflammatory_respons0.72841843
123MP0001533_abnormal_skeleton_physiology0.72548212
124MP0001790_abnormal_immune_system0.71600272
125MP0005387_immune_system_phenotype0.71600272
126* MP0001765_abnormal_ion_homeostasis0.71416635
127MP0005025_abnormal_response_to0.71344344
128MP0008004_abnormal_stomach_pH0.70052821
129MP0003329_amyloid_beta_deposits0.69158149
130MP0002933_joint_inflammation0.68664759
131MP0009643_abnormal_urine_homeostasis0.68048946
132MP0005164_abnormal_response_to0.67722150
133MP0008995_early_reproductive_senescence0.67254754
134MP0008057_abnormal_DNA_replication0.65729988
135MP0006054_spinal_hemorrhage0.65661565
136MP0001346_abnormal_lacrimal_gland0.65570058
137MP0002136_abnormal_kidney_physiology0.64810709
138MP0009765_abnormal_xenobiotic_induced0.64538478
139MP0005319_abnormal_enzyme/_coenzyme0.64236337
140MP0003724_increased_susceptibility_to0.63581656
141MP0005389_reproductive_system_phenotype0.62430082
142MP0005167_abnormal_blood-brain_barrier0.62194338
143MP0005666_abnormal_adipose_tissue0.61758926
144MP0003868_abnormal_feces_composition0.60696480
145MP0005390_skeleton_phenotype0.60686559
146MP0003011_delayed_dark_adaptation0.60383268
147MP0008469_abnormal_protein_level0.60012471
148MP0008961_abnormal_basal_metabolism0.59365632
149MP0005671_abnormal_response_to0.58080390
150MP0009333_abnormal_splenocyte_physiolog0.57093247
151MP0002148_abnormal_hypersensitivity_rea0.56063647
152MP0002234_abnormal_pharynx_morphology0.55573841
153MP0002723_abnormal_immune_serum0.55072025
154MP0002405_respiratory_system_inflammati0.54274699

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)6.24606206
2Increased IgE level (HP:0003212)5.70479408
3Onycholysis (HP:0001806)5.46813950
4Elevated erythrocyte sedimentation rate (HP:0003565)5.01020593
5Congenital ichthyosiform erythroderma (HP:0007431)4.96876253
6Retrobulbar optic neuritis (HP:0100654)4.94197773
7Optic neuritis (HP:0100653)4.94197773
8Plantar hyperkeratosis (HP:0007556)4.93780672
9Hypotrichosis (HP:0001006)4.87437823
10Myositis (HP:0100614)4.84199180
11Abnormality of T cell number (HP:0011839)4.72029361
12Orchitis (HP:0100796)4.67937352
13T lymphocytopenia (HP:0005403)4.60163721
14Woolly hair (HP:0002224)4.58969013
15Abnormality of nail color (HP:0100643)4.38557424
16Palmoplantar hyperkeratosis (HP:0000972)4.24438566
17Fragile nails (HP:0001808)4.07188658
18Milia (HP:0001056)3.99022240
19Intrahepatic cholestasis (HP:0001406)3.95735942
20Palmar hyperkeratosis (HP:0010765)3.90883825
21Recurrent bacterial skin infections (HP:0005406)3.81744348
22Abnormal delayed hypersensitivity skin test (HP:0002963)3.78867194
23Keratoconjunctivitis sicca (HP:0001097)3.69216216
24Abnormality of monocarboxylic acid metabolism (HP:0010996)3.64277122
25Abnormality of T cells (HP:0002843)3.61205226
26Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.57273388
27Erythroderma (HP:0001019)3.55713760
28Autoimmune hemolytic anemia (HP:0001890)3.53643622
29Deep venous thrombosis (HP:0002625)3.53097158
30Keratoconjunctivitis (HP:0001096)3.52048311
31Pili torti (HP:0003777)3.48827225
32Xanthomatosis (HP:0000991)3.48027413
33Parakeratosis (HP:0001036)3.46472648
34Gastrointestinal infarctions (HP:0005244)3.45151396
35Recurrent abscess formation (HP:0002722)3.43467848
36Recurrent fungal infections (HP:0002841)3.34364808
37Nail dystrophy (HP:0008404)3.32465236
38Eczematoid dermatitis (HP:0000976)3.29321690
39IgG deficiency (HP:0004315)3.26287327
40Hypobetalipoproteinemia (HP:0003563)3.26185965
41Abnormality of eosinophils (HP:0001879)3.21768556
42Erythema (HP:0010783)3.21144211
43Gangrene (HP:0100758)3.17184513
44Pulmonary infiltrates (HP:0002113)3.17155603
45Vasculitis (HP:0002633)3.15061554
46Abnormal blistering of the skin (HP:0008066)3.11442289
47Abnormality of T cell physiology (HP:0011840)3.10948315
48Increased IgM level (HP:0003496)3.10231203
49Severe combined immunodeficiency (HP:0004430)3.09930285
50Encephalitis (HP:0002383)3.07898373
51Alopecia of scalp (HP:0002293)3.06061621
52Pustule (HP:0200039)3.05771330
53Thyroiditis (HP:0100646)3.04544220
54Recurrent skin infections (HP:0001581)3.03849321
55Thick nail (HP:0001805)3.02388423
56Curly hair (HP:0002212)3.00870385
57Leukocytosis (HP:0001974)3.00266974
58Lip pit (HP:0100267)2.93558435
59Abnormality of aromatic amino acid family metabolism (HP:0004338)2.92493839
60Eosinophilia (HP:0001880)2.91621373
61Abnormality of macrophages (HP:0004311)2.82105667
62Mediastinal lymphadenopathy (HP:0100721)2.81496399
63Ectropion (HP:0000656)2.80397847
64Pruritus (HP:0000989)2.78338082
65Vascular calcification (HP:0004934)2.76997775
66Hypochromic anemia (HP:0001931)2.76456197
67Anorexia (HP:0002039)2.74245412
68Arterial thrombosis (HP:0004420)2.70736828
69Recurrent gram-negative bacterial infections (HP:0005420)2.70522865
70Chronic mucocutaneous candidiasis (HP:0002728)2.68931969
71Recurrent cutaneous fungal infections (HP:0011370)2.68931969
72Abnormality of glutamine family amino acid metabolism (HP:0010902)2.66994259
73Hemoptysis (HP:0002105)2.66423392
74Meningitis (HP:0001287)2.65582265
75Abnormality of the common coagulation pathway (HP:0010990)2.64152122
76Atrophic scars (HP:0001075)2.64090433
77Corneal erosion (HP:0200020)2.61945996
78Epidermoid cyst (HP:0200040)2.59191133
79Prolonged partial thromboplastin time (HP:0003645)2.58149842
80Hypochromic microcytic anemia (HP:0004840)2.55676662
81Hyporeflexia of lower limbs (HP:0002600)2.55542581
82Autoimmune thrombocytopenia (HP:0001973)2.55452028
83Granulocytopenia (HP:0001913)2.55343326
84Hypohidrosis (HP:0000966)2.53842416
85Recurrent bronchitis (HP:0002837)2.52727267
86Abnormality of the gastric mucosa (HP:0004295)2.51741059
87Abnormal hair laboratory examination (HP:0003328)2.50143224
88Chronic diarrhea (HP:0002028)2.47255529
89Cardiovascular calcification (HP:0011915)2.46121257
90Hypolipoproteinemia (HP:0010981)2.45097611
91Fat malabsorption (HP:0002630)2.44422315
92Joint swelling (HP:0001386)2.41961652
93Acanthosis nigricans (HP:0000956)2.41887413
94Alveolar cell carcinoma (HP:0006519)2.41168613
95Ventricular tachycardia (HP:0004756)2.40129030
96Stomach cancer (HP:0012126)2.38888973
97Neoplasm of the tracheobronchial system (HP:0100552)2.37666356
98Myocardial infarction (HP:0001658)2.34109750
99Episodic fever (HP:0001954)2.33162937
100Prolonged bleeding time (HP:0003010)2.32472867
101Complement deficiency (HP:0004431)2.30228876
102Dehydration (HP:0001944)2.30178748
103Recurrent viral infections (HP:0004429)2.29887774
104Hyperlipoproteinemia (HP:0010980)2.26772806
105Distal lower limb muscle weakness (HP:0009053)2.25047172
106Palmoplantar keratoderma (HP:0000982)2.24108898
107Sparse eyelashes (HP:0000653)2.22851373
108Pulmonary embolism (HP:0002204)2.22737403
109Malnutrition (HP:0004395)2.20471183
110Chest pain (HP:0100749)2.18137571
111Petechiae (HP:0000967)2.17584115
112Oral leukoplakia (HP:0002745)2.17146314
113Conjunctival hamartoma (HP:0100780)2.16469539
114Keratitis (HP:0000491)2.15011105
115Acute hepatic failure (HP:0006554)2.13067308
116Obstructive lung disease (HP:0006536)2.11547708
117Chronic obstructive pulmonary disease (HP:0006510)2.11547708
118Combined immunodeficiency (HP:0005387)2.11467814
119Hypergammaglobulinemia (HP:0010702)2.10813977
120Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.10365871
121Conjugated hyperbilirubinemia (HP:0002908)2.08525068
122Hypoalphalipoproteinemia (HP:0003233)2.07910816
123Spontaneous hematomas (HP:0007420)2.07684246
124Esophageal varix (HP:0002040)2.02219969
125Hyperammonemia (HP:0001987)2.00777105
126Abnormality of the pleura (HP:0002103)2.00154360
127Bronchitis (HP:0012387)1.98209459
128Urticaria (HP:0001025)1.97184049
129Abnormality of complement system (HP:0005339)1.96895344
130Brittle hair (HP:0002299)1.96549782
131Ridged nail (HP:0001807)1.96484555
132Abnormality of sulfur amino acid metabolism (HP:0004339)1.92594801
133Abnormality of the prostate (HP:0008775)1.91661458
134Advanced eruption of teeth (HP:0006288)1.91177342
135Interstitial pulmonary disease (HP:0006530)1.90252823
136Panhypogammaglobulinemia (HP:0003139)1.90018560
137Anhidrosis (HP:0000970)1.89537660
138Skin ulcer (HP:0200042)1.87805184
139Abnormality of proline metabolism (HP:0010907)1.86929152
140Hydroxyprolinuria (HP:0003080)1.86929152
141Gingivitis (HP:0000230)1.85539819
142Chronic otitis media (HP:0000389)1.85293104
143Lack of skin elasticity (HP:0100679)1.84826391
144Stomatitis (HP:0010280)1.84391916
145Villous atrophy (HP:0011473)1.84051176
146Abnormality of small intestinal villus morphology (HP:0011472)1.84051176
147Dry skin (HP:0000958)1.83989101
148Ileus (HP:0002595)1.83471767
149Oligodontia (HP:0000677)1.81811163
150Epistaxis (HP:0000421)1.80877970
151Recurrent sinusitis (HP:0011108)1.80695031
152Abnormality of the Achilles tendon (HP:0005109)1.80431982
153Bronchiectasis (HP:0002110)1.80318253
154Premature loss of primary teeth (HP:0006323)1.79473212
155Abnormality of the renal cortex (HP:0011035)1.79096662
156Sepsis (HP:0100806)1.77251838
157Rickets (HP:0002748)1.76579932
158Joint hemorrhage (HP:0005261)1.75870466
159Gingival bleeding (HP:0000225)1.75288927
160Chronic sinusitis (HP:0011109)1.75281472
161Abnormality of aspartate family amino acid metabolism (HP:0010899)1.74370508
162Steatorrhea (HP:0002570)1.73271456
163Prostate neoplasm (HP:0100787)1.73082724
164Hypoproteinemia (HP:0003075)1.73003275
165Abnormality of cells of the lymphoid lineage (HP:0012140)1.72394560
166Vertigo (HP:0002321)1.71753416
167Type I diabetes mellitus (HP:0100651)1.70522108
168Abnormal hemoglobin (HP:0011902)1.70265012
169Blepharitis (HP:0000498)1.67224304
170Increased mean platelet volume (HP:0011877)1.66175047
171Thin bony cortex (HP:0002753)1.65979866
172Hypoplasia of dental enamel (HP:0006297)1.65246125
173Abnormality of secondary sexual hair (HP:0009888)1.65222701
174Abnormality of the axillary hair (HP:0100134)1.65222701
175Late onset (HP:0003584)1.64952517
176Ventricular fibrillation (HP:0001663)1.62905864
177Abnormality of the intrinsic pathway (HP:0010989)1.61911886

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.50561456
2MST44.23901682
3MST1R3.14548622
4MAP3K32.81353994
5ERN12.75652937
6FER2.71651368
7RIPK42.61084617
8FGFR42.54251341
9SIK32.40990197
10IRAK42.31991569
11TRIB32.22409299
12STK102.22216254
13MAPKAPK32.22072236
14PTK62.21217922
15FRK2.21071451
16FES2.18402791
17LATS12.13525899
18SIK11.93786779
19MAP3K141.87442764
20EPHB11.72541924
21PIK3CG1.63954357
22TYK21.61939152
23RPS6KB21.61573358
24EPHA31.61290175
25LRRK21.59767230
26MAP3K21.52986623
27ITK1.52246708
28BMPR21.51580484
29EIF2AK31.51121136
30IRAK11.46559655
31TESK11.40078635
32STK241.37949193
33SYK1.37735662
34MAP3K121.33091039
35PTK21.31509720
36MAP4K11.30832352
37ZAP701.28295301
38STK38L1.27072074
39TRPM71.26078565
40TBK11.20030652
41OXSR11.16523267
42BLK1.16386818
43CAMKK21.15266296
44MAP2K21.15146543
45NEK91.13640673
46AKT31.12874579
47IKBKE1.11945845
48MAP3K71.11401423
49EPHB21.10550336
50RPS6KA41.08919351
51RIPK11.08831511
52FGFR31.07908671
53CSK1.05609374
54FGFR11.04862661
55TXK1.03477619
56MAP2K31.01265095
57LYN1.00735893
58JAK10.99433413
59ERBB40.97578270
60MAP3K130.97431586
61TAOK10.92483502
62MAP3K90.91434989
63MAP4K20.89223771
64JAK30.89078858
65IRAK30.89068889
66MARK30.87547121
67CDK60.86572410
68EEF2K0.84813218
69MAP3K110.83861843
70MET0.83684474
71DAPK20.82627357
72MAP3K10.82424461
73PIM20.82111075
74BCKDK0.81444083
75GRK60.79815396
76SGK20.78497613
77STK390.78103632
78TESK20.77884506
79MAP3K100.76024214
80IKBKB0.75127037
81CHUK0.74066086
82TTN0.73652922
83PKN20.73192510
84GRK70.73075203
85ACVR1B0.71721757
86KIT0.71604922
87TAOK30.71255505
88DYRK1B0.69580272
89TLK10.69513802
90MAP2K60.68196027
91JAK20.66436850
92CSF1R0.63221521
93MAP3K80.62001541
94PDK10.61335273
95ADRBK20.61230420
96SGK30.60229474
97NLK0.59799285
98TRIM280.59390020
99BCR0.57848724
100YES10.56614768
101MAP2K10.56538201
102HIPK20.56245025
103GRK10.55268721
104STK30.55179775
105ADRBK10.54533647
106LIMK10.54347263
107MAP3K50.53446353
108NEK60.52336741
109HCK0.51991476
110MAPKAPK20.51615598
111PTK2B0.51352762
112TGFBR20.49533656
113PRKAA20.48839760
114IRAK20.48839248
115PIM10.47662000
116FGR0.47037164
117GRK50.46815531
118KDR0.46766109
119TNK20.45767391
120PASK0.45558847
121MATK0.44353331
122TEC0.44303531
123PAK30.43798788
124MAPK110.43749505
125INSRR0.43470804
126IGF1R0.42598238
127NUAK10.42367980
128BTK0.41352522
129PRKCQ0.39266249
130ERBB20.39234145
131SGK4940.37997409
132SGK2230.37997409
133LMTK20.37416794
134LCK0.37198918
135EGFR0.37067201
136PRKG20.35877466
137PRKCI0.35284539
138GSK3A0.34583253
139ABL10.32788135
140PIK3CA0.32684088
141ERBB30.32166131
142FGFR20.30753067
143STK380.30494132

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.06437702
2Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.91618559
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.56899950
4Graft-versus-host disease_Homo sapiens_hsa053322.53654431
5Cyanoamino acid metabolism_Homo sapiens_hsa004602.52812612
6Histidine metabolism_Homo sapiens_hsa003402.50644273
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.42574583
8Allograft rejection_Homo sapiens_hsa053302.33138576
9Autoimmune thyroid disease_Homo sapiens_hsa053202.28576840
10Measles_Homo sapiens_hsa051622.23677758
11Fat digestion and absorption_Homo sapiens_hsa049752.22541080
12Nitrogen metabolism_Homo sapiens_hsa009102.21396947
13Arginine biosynthesis_Homo sapiens_hsa002202.18433809
14Type I diabetes mellitus_Homo sapiens_hsa049402.12985752
15Caffeine metabolism_Homo sapiens_hsa002322.12385630
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.09849286
17Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.05101233
18Complement and coagulation cascades_Homo sapiens_hsa046102.01810364
19Phenylalanine metabolism_Homo sapiens_hsa003602.01770421
20Retinol metabolism_Homo sapiens_hsa008301.96665687
21Staphylococcus aureus infection_Homo sapiens_hsa051501.92153360
22Chemical carcinogenesis_Homo sapiens_hsa052041.89745078
23Tryptophan metabolism_Homo sapiens_hsa003801.85888303
24B cell receptor signaling pathway_Homo sapiens_hsa046621.81111862
25Fatty acid degradation_Homo sapiens_hsa000711.79649130
26Antigen processing and presentation_Homo sapiens_hsa046121.72328309
27Sulfur metabolism_Homo sapiens_hsa009201.67122077
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.58943489
29Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.53105219
30Chemokine signaling pathway_Homo sapiens_hsa040621.52615833
31Legionellosis_Homo sapiens_hsa051341.52228484
32Pentose and glucuronate interconversions_Homo sapiens_hsa000401.51207329
33alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.50464404
34Tuberculosis_Homo sapiens_hsa051521.50415499
35beta-Alanine metabolism_Homo sapiens_hsa004101.48818840
36Toll-like receptor signaling pathway_Homo sapiens_hsa046201.46353641
37Steroid biosynthesis_Homo sapiens_hsa001001.45300368
38Linoleic acid metabolism_Homo sapiens_hsa005911.40716047
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.40174039
40PPAR signaling pathway_Homo sapiens_hsa033201.39623052
41Steroid hormone biosynthesis_Homo sapiens_hsa001401.34499841
42Malaria_Homo sapiens_hsa051441.31827927
43Herpes simplex infection_Homo sapiens_hsa051681.27969854
44SNARE interactions in vesicular transport_Homo sapiens_hsa041301.25920271
45ABC transporters_Homo sapiens_hsa020101.21815963
46Tyrosine metabolism_Homo sapiens_hsa003501.21762485
47Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.21043788
48Bile secretion_Homo sapiens_hsa049761.20422250
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.19586100
50Regulation of autophagy_Homo sapiens_hsa041401.17523388
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.16000428
52Platelet activation_Homo sapiens_hsa046111.14971223
53Leukocyte transendothelial migration_Homo sapiens_hsa046701.14485618
54Sphingolipid metabolism_Homo sapiens_hsa006001.14444151
55Primary immunodeficiency_Homo sapiens_hsa053401.13577466
56Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.12527480
57Dorso-ventral axis formation_Homo sapiens_hsa043201.10545879
58Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.09725074
59Peroxisome_Homo sapiens_hsa041461.09340125
60Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.09094585
61Vitamin digestion and absorption_Homo sapiens_hsa049771.08966614
62Circadian rhythm_Homo sapiens_hsa047101.08888309
63Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.08587041
64Fatty acid elongation_Homo sapiens_hsa000621.07956452
65Fatty acid metabolism_Homo sapiens_hsa012121.06782664
66Influenza A_Homo sapiens_hsa051641.05543933
67Asthma_Homo sapiens_hsa053101.01296641
68Adherens junction_Homo sapiens_hsa045201.00244219
69Folate biosynthesis_Homo sapiens_hsa007900.97994750
70Bladder cancer_Homo sapiens_hsa052190.95720084
71Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.95353077
72Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.94703542
73Starch and sucrose metabolism_Homo sapiens_hsa005000.89968583
74T cell receptor signaling pathway_Homo sapiens_hsa046600.87666772
75Glycerolipid metabolism_Homo sapiens_hsa005610.86898212
76Non-small cell lung cancer_Homo sapiens_hsa052230.86741055
77Glutathione metabolism_Homo sapiens_hsa004800.86359353
78Drug metabolism - other enzymes_Homo sapiens_hsa009830.84676848
79Maturity onset diabetes of the young_Homo sapiens_hsa049500.83944791
80Arachidonic acid metabolism_Homo sapiens_hsa005900.83129201
81African trypanosomiasis_Homo sapiens_hsa051430.81317414
82Hepatitis B_Homo sapiens_hsa051610.79254297
83Rheumatoid arthritis_Homo sapiens_hsa053230.79091458
84Hepatitis C_Homo sapiens_hsa051600.78775898
85Selenocompound metabolism_Homo sapiens_hsa004500.77782977
86NF-kappa B signaling pathway_Homo sapiens_hsa040640.75739415
87Apoptosis_Homo sapiens_hsa042100.75561058
88Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.73226686
89Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.72770800
90Tight junction_Homo sapiens_hsa045300.71472338
91Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71423834
92Toxoplasmosis_Homo sapiens_hsa051450.70365154
93Shigellosis_Homo sapiens_hsa051310.70164469
94Prolactin signaling pathway_Homo sapiens_hsa049170.70062239
95FoxO signaling pathway_Homo sapiens_hsa040680.69894758
96Butanoate metabolism_Homo sapiens_hsa006500.69222089
97Collecting duct acid secretion_Homo sapiens_hsa049660.68962796
98Insulin resistance_Homo sapiens_hsa049310.66962568
99Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65550824
100Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.65147372
101Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64305925
102TNF signaling pathway_Homo sapiens_hsa046680.64107923
103Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.63623937
104Fatty acid biosynthesis_Homo sapiens_hsa000610.63323549
105Mineral absorption_Homo sapiens_hsa049780.62696128
106Jak-STAT signaling pathway_Homo sapiens_hsa046300.62614751
107Propanoate metabolism_Homo sapiens_hsa006400.60061001
108Inositol phosphate metabolism_Homo sapiens_hsa005620.58991429
109Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.58541521
110Intestinal immune network for IgA production_Homo sapiens_hsa046720.58135442
111Osteoclast differentiation_Homo sapiens_hsa043800.57292233
112Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55828040
113Viral myocarditis_Homo sapiens_hsa054160.55645244
114Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54191327
115Glycerophospholipid metabolism_Homo sapiens_hsa005640.53854478
116Pancreatic secretion_Homo sapiens_hsa049720.53637176
117Hematopoietic cell lineage_Homo sapiens_hsa046400.53332990
118Small cell lung cancer_Homo sapiens_hsa052220.52905828
119Endocytosis_Homo sapiens_hsa041440.52202881
120Acute myeloid leukemia_Homo sapiens_hsa052210.52180019
121Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51556545
122Sphingolipid signaling pathway_Homo sapiens_hsa040710.50477131
123Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.49642995
124Adipocytokine signaling pathway_Homo sapiens_hsa049200.49310274
125Phagosome_Homo sapiens_hsa041450.48613543
126mTOR signaling pathway_Homo sapiens_hsa041500.47445905
127Pyruvate metabolism_Homo sapiens_hsa006200.47327073
128Viral carcinogenesis_Homo sapiens_hsa052030.46832433
129Proteoglycans in cancer_Homo sapiens_hsa052050.46794544
130Pentose phosphate pathway_Homo sapiens_hsa000300.46402604
131Ether lipid metabolism_Homo sapiens_hsa005650.45718392
132Type II diabetes mellitus_Homo sapiens_hsa049300.44959624
133Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44829885
134Biosynthesis of amino acids_Homo sapiens_hsa012300.44772020
135Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43816566
136MAPK signaling pathway_Homo sapiens_hsa040100.43625524
137Leishmaniasis_Homo sapiens_hsa051400.43606181
138Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42844164
139Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42711048
140Protein export_Homo sapiens_hsa030600.42640018
141Pancreatic cancer_Homo sapiens_hsa052120.40136176
142Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.39720352
143VEGF signaling pathway_Homo sapiens_hsa043700.38782032
144Amoebiasis_Homo sapiens_hsa051460.38081244
145Thyroid cancer_Homo sapiens_hsa052160.37577487
146Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37476775
147Carbon metabolism_Homo sapiens_hsa012000.36338143
148NOD-like receptor signaling pathway_Homo sapiens_hsa046210.35356656
149Phototransduction_Homo sapiens_hsa047440.35095096
150Epstein-Barr virus infection_Homo sapiens_hsa051690.35038996
151Choline metabolism in cancer_Homo sapiens_hsa052310.35020269
152Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.34571454
153Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34474300
154Lysosome_Homo sapiens_hsa041420.34255695
155Transcriptional misregulation in cancer_Homo sapiens_hsa052020.34238788
156Pertussis_Homo sapiens_hsa051330.34145074
157Renal cell carcinoma_Homo sapiens_hsa052110.33789407
158RNA degradation_Homo sapiens_hsa030180.33653038
159Lysine degradation_Homo sapiens_hsa003100.31859498
160Ovarian steroidogenesis_Homo sapiens_hsa049130.31158009
161Fructose and mannose metabolism_Homo sapiens_hsa000510.28023380
162RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.27095514

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