MPST

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This protein encoded by this gene catalyzes the transfer of a sulfur ion from 3-mercaptopyruvate to cyanide or other thiol compounds. It may be involved in cysteine degradation and cyanide detoxification. There is confusion in literature between this protein (mercaptopyruvate sulfurtransferase, MPST), which appears to be cytoplasmic, and thiosulfate sulfurtransferase (rhodanese, TST, GeneID:7263), which is a mitochondrial protein. Deficiency in MPST activity has been implicated in a rare inheritable disorder known as mercaptolactate-cysteine disulfiduria (MCDU). Alternatively spliced transcript variants encoding same or different isoforms have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.62394342
2L-phenylalanine catabolic process (GO:0006559)6.62394342
3L-phenylalanine metabolic process (GO:0006558)6.41265552
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.41265552
5aromatic amino acid family catabolic process (GO:0009074)5.98575358
6cellular ketone body metabolic process (GO:0046950)5.89142937
7sulfur amino acid catabolic process (GO:0000098)5.87003406
8glyoxylate metabolic process (GO:0046487)5.49541465
9epoxygenase P450 pathway (GO:0019373)5.47763420
10triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.47389101
11kynurenine metabolic process (GO:0070189)5.47226623
12tryptophan catabolic process (GO:0006569)5.40927722
13indole-containing compound catabolic process (GO:0042436)5.40927722
14indolalkylamine catabolic process (GO:0046218)5.40927722
15cysteine metabolic process (GO:0006534)5.29117308
16alpha-linolenic acid metabolic process (GO:0036109)5.29007292
17lysine metabolic process (GO:0006553)5.22683015
18lysine catabolic process (GO:0006554)5.22683015
19negative regulation of cholesterol transport (GO:0032375)5.13912672
20negative regulation of sterol transport (GO:0032372)5.13912672
21ketone body metabolic process (GO:1902224)5.11521212
22tryptophan metabolic process (GO:0006568)5.08776822
23bile acid biosynthetic process (GO:0006699)5.07931351
24urea cycle (GO:0000050)4.81612054
25urea metabolic process (GO:0019627)4.81612054
26high-density lipoprotein particle remodeling (GO:0034375)4.76880834
27fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.71650022
28negative regulation of fibrinolysis (GO:0051918)4.69516114
29serine family amino acid catabolic process (GO:0009071)4.69229769
30drug metabolic process (GO:0017144)4.63729784
31proline metabolic process (GO:0006560)4.49448954
32protein carboxylation (GO:0018214)4.49211967
33peptidyl-glutamic acid carboxylation (GO:0017187)4.49211967
34complement activation, alternative pathway (GO:0006957)4.48659850
35homocysteine metabolic process (GO:0050667)4.44984846
36nitrogen cycle metabolic process (GO:0071941)4.41537685
37bile acid metabolic process (GO:0008206)4.39570213
38ethanol oxidation (GO:0006069)4.39251231
39amino-acid betaine metabolic process (GO:0006577)4.38532336
40regulation of fibrinolysis (GO:0051917)4.37971911
41regulation of triglyceride catabolic process (GO:0010896)4.34901391
42regulation of protein activation cascade (GO:2000257)4.32038652
43aromatic amino acid family metabolic process (GO:0009072)4.30042385
44flavonoid metabolic process (GO:0009812)4.29679955
45alpha-amino acid catabolic process (GO:1901606)4.25885639
46cellular glucuronidation (GO:0052695)4.25269043
47regulation of cholesterol homeostasis (GO:2000188)4.24674125
48reverse cholesterol transport (GO:0043691)4.20134617
49bile acid and bile salt transport (GO:0015721)4.15175284
50short-chain fatty acid metabolic process (GO:0046459)4.11252593
51phospholipid efflux (GO:0033700)4.11185786
52cellular amino acid catabolic process (GO:0009063)4.08172667
53macromolecular complex remodeling (GO:0034367)4.07562346
54plasma lipoprotein particle remodeling (GO:0034369)4.07562346
55protein-lipid complex remodeling (GO:0034368)4.07562346
56tyrosine metabolic process (GO:0006570)4.05745844
57regulation of complement activation (GO:0030449)4.04442345
58glutamate metabolic process (GO:0006536)4.03734676
59cellular modified amino acid catabolic process (GO:0042219)3.99430154
60triglyceride homeostasis (GO:0070328)3.98677306
61acylglycerol homeostasis (GO:0055090)3.98677306
62drug catabolic process (GO:0042737)3.98433727
63regulation of cholesterol esterification (GO:0010872)3.97198039
64blood coagulation, intrinsic pathway (GO:0007597)3.95345790
65oxidative demethylation (GO:0070989)3.89178986
66serine family amino acid metabolic process (GO:0009069)3.88065749
67alkaloid metabolic process (GO:0009820)3.87067859
68plasma lipoprotein particle clearance (GO:0034381)3.85571143
69coenzyme catabolic process (GO:0009109)3.85277543
70benzene-containing compound metabolic process (GO:0042537)3.83385970
71plasma lipoprotein particle assembly (GO:0034377)3.81482091
72aspartate family amino acid catabolic process (GO:0009068)3.81115428
73glycine metabolic process (GO:0006544)3.80709543
742-oxoglutarate metabolic process (GO:0006103)3.79791730
75proline biosynthetic process (GO:0006561)3.79733229
76acetyl-CoA metabolic process (GO:0006084)3.79638937
77very-low-density lipoprotein particle assembly (GO:0034379)3.79342494
78uronic acid metabolic process (GO:0006063)3.78391452
79glucuronate metabolic process (GO:0019585)3.78391452
80NADH metabolic process (GO:0006734)3.77915988
81omega-hydroxylase P450 pathway (GO:0097267)3.76234164
82fatty acid beta-oxidation (GO:0006635)3.74674111
83dicarboxylic acid biosynthetic process (GO:0043650)3.73930488
84indolalkylamine metabolic process (GO:0006586)3.72560174
85fatty acid oxidation (GO:0019395)3.71850140
86phospholipid homeostasis (GO:0055091)3.70341875
87lipid oxidation (GO:0034440)3.64636832
88carboxylic acid catabolic process (GO:0046395)3.64523821
89organic acid catabolic process (GO:0016054)3.64523821
90regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.62992405
91serine family amino acid biosynthetic process (GO:0009070)3.62972128
92arginine catabolic process (GO:0006527)3.62389736
93drug transmembrane transport (GO:0006855)3.60400868
94intestinal absorption (GO:0050892)3.59832146
95positive regulation of fatty acid biosynthetic process (GO:0045723)3.59804246
96exogenous drug catabolic process (GO:0042738)3.59044735
97cellular biogenic amine catabolic process (GO:0042402)3.56276409
98amine catabolic process (GO:0009310)3.56276409
99positive regulation of triglyceride lipase activity (GO:0061365)3.53992704
100positive regulation of lipoprotein lipase activity (GO:0051006)3.53992704
101cholesterol homeostasis (GO:0042632)3.53887774
102monocarboxylic acid catabolic process (GO:0072329)3.53623441
103fatty acid catabolic process (GO:0009062)3.51197204
104protein-lipid complex assembly (GO:0065005)3.50624944
105sterol homeostasis (GO:0055092)3.50514976
106arginine metabolic process (GO:0006525)3.48538081
107urate metabolic process (GO:0046415)3.47937320
108cholesterol efflux (GO:0033344)3.47822767
109ethanol metabolic process (GO:0006067)3.47066620
110imidazole-containing compound metabolic process (GO:0052803)3.46173463
111positive regulation of lipid catabolic process (GO:0050996)3.45030375
112positive regulation of triglyceride metabolic process (GO:0090208)3.42390948
113low-density lipoprotein particle remodeling (GO:0034374)3.42174588
114carnitine metabolic process (GO:0009437)3.40894097
115phosphate ion transmembrane transport (GO:0035435)3.40601629
116plasma lipoprotein particle organization (GO:0071827)3.38929931
117phenylpropanoid metabolic process (GO:0009698)3.36906646
118quinone biosynthetic process (GO:1901663)3.32720372
119diacylglycerol metabolic process (GO:0046339)3.31966742
120fat-soluble vitamin biosynthetic process (GO:0042362)3.28255958
121regulation of plasminogen activation (GO:0010755)3.27114722
122glutamine family amino acid biosynthetic process (GO:0009084)3.19334867
123fibrinolysis (GO:0042730)3.11812942
124protein-lipid complex subunit organization (GO:0071825)3.09506844
125quinone metabolic process (GO:1901661)3.09481098
126regulation of lipoprotein particle clearance (GO:0010984)3.08202581
127polyketide metabolic process (GO:0030638)3.07273703
128doxorubicin metabolic process (GO:0044598)3.07273703
129daunorubicin metabolic process (GO:0044597)3.07273703
130protein activation cascade (GO:0072376)3.07131442
131regulation of bile acid biosynthetic process (GO:0070857)3.00143834
132intestinal cholesterol absorption (GO:0030299)2.99539222
133oxaloacetate metabolic process (GO:0006107)2.98747739
134negative regulation of blood coagulation (GO:0030195)2.98341138
135negative regulation of hemostasis (GO:1900047)2.98341138
136cofactor catabolic process (GO:0051187)2.98112677
137complement activation, classical pathway (GO:0006958)2.97245887
138L-ascorbic acid metabolic process (GO:0019852)2.92340912

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.25899689
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.46875505
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.89351598
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.53968143
5EGR1_23403033_ChIP-Seq_LIVER_Mouse5.21868645
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.53772028
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.08719597
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.39836307
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.88853936
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.76539534
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.51024445
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.18173323
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.16717043
14ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.2752497
15CLOCK_20551151_ChIP-Seq_293T_Human1.98466457
16HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.96196500
17* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.91344377
18CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.84489185
19RARG_19884340_ChIP-ChIP_MEFs_Mouse1.73516000
20* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.73152124
21ELF1_20517297_ChIP-Seq_JURKAT_Human1.71227777
22THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.70827843
23ZNF263_19887448_ChIP-Seq_K562_Human1.70462507
24E2F1_20622854_ChIP-Seq_HELA_Human1.68162009
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.65429043
26* PHF8_20622854_ChIP-Seq_HELA_Human1.64367089
27MYC_18358816_ChIP-ChIP_MESCs_Mouse1.58828404
28* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.56898053
29HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.52728385
30CTCF_27219007_Chip-Seq_Bcells_Human1.51637054
31YY1_22570637_ChIP-Seq_MALME-3M_Human1.50108693
32* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.48952752
33FOXA2_19822575_ChIP-Seq_HepG2_Human1.46563498
34CTCF_20526341_ChIP-Seq_ESCs_Human1.46513782
35STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.44605322
36SA1_27219007_Chip-Seq_Bcells_Human1.44172629
37LXR_22292898_ChIP-Seq_THP-1_Human1.44068898
38SRF_21415370_ChIP-Seq_HL-1_Mouse1.41774990
39CTCF_18555785_ChIP-Seq_MESCs_Mouse1.38761811
40* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.37864325
41ERA_21632823_ChIP-Seq_H3396_Human1.36494877
42P300_27268052_Chip-Seq_Bcells_Human1.35849158
43ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.34876639
44EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.34631452
45ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.34545053
46SA1_27219007_Chip-Seq_ERYTHROID_Human1.34210253
47STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.33376114
48* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.32512447
49FOXP1_21924763_ChIP-Seq_HESCs_Human1.31826401
50CTCF_26484167_Chip-Seq_Bcells_Mouse1.31165210
51ESR1_15608294_ChIP-ChIP_MCF-7_Human1.29161779
52HNF4A_19822575_ChIP-Seq_HepG2_Human1.26929390
53RAC3_21632823_ChIP-Seq_H3396_Human1.23016959
54RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.22177157
55* CTCF_21964334_Chip-Seq_Bcells_Human1.18442629
56ETS1_20019798_ChIP-Seq_JURKAT_Human1.18420683
57ESR2_21235772_ChIP-Seq_MCF-7_Human1.17170807
58RACK7_27058665_Chip-Seq_MCF-7_Human1.16762793
59PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.15519978
60GATA4_25053715_ChIP-Seq_YYC3_Human1.15480199
61SMC4_20622854_ChIP-Seq_HELA_Human1.14761723
62ETS1_21867929_ChIP-Seq_TH2_Mouse1.13699271
63GABP_19822575_ChIP-Seq_HepG2_Human1.13160971
64P53_21459846_ChIP-Seq_SAOS-2_Human1.11828303
65NANOG_20526341_ChIP-Seq_ESCs_Human1.09571472
66CDX2_20551321_ChIP-Seq_CACO-2_Human1.09334397
67GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.09065876
68IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.08963903
69THAP11_20581084_ChIP-Seq_MESCs_Mouse1.07531498
70* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07508325
71CTCF_27219007_Chip-Seq_ERYTHROID_Human1.07057618
72TAF2_19829295_ChIP-Seq_ESCs_Human1.07027714
73GATA1_19941826_ChIP-Seq_K562_Human1.05202998
74TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.04911998
75TP63_17297297_ChIP-ChIP_HaCaT_Human1.04707011
76* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.03774177
77LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.03427064
78LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.02471702
79NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.02341068
80SRY_22984422_ChIP-ChIP_TESTIS_Rat1.02160791
81RXRA_24833708_ChIP-Seq_LIVER_Mouse1.01726521
82* EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.01684339
83E2F1_18555785_ChIP-Seq_MESCs_Mouse1.01519392
84GATA6_25053715_ChIP-Seq_YYC3_Human1.01370296
85TP63_22573176_ChIP-Seq_HFKS_Human1.01083351
86XRN2_22483619_ChIP-Seq_HELA_Human0.99540366
87* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.99529732
88STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99058931
89GATA1_22025678_ChIP-Seq_K562_Human0.96960439
90DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.95996482
91YY1_21170310_ChIP-Seq_MESCs_Mouse0.95888419
92SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.95326768
93SOX2_21211035_ChIP-Seq_LN229_Human0.94461563
94PU.1_20513432_ChIP-Seq_Bcells_Mouse0.94197145
95NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.92938614
96* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.91233812
97* GATA1_19941827_ChIP-Seq_MEL_Mouse0.90589027
98ERG_21242973_ChIP-ChIP_JURKAT_Human0.88658239
99HTT_18923047_ChIP-ChIP_STHdh_Human0.86550264
100CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.86000010
101KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.85117648
102GATA2_19941826_ChIP-Seq_K562_Human0.84301097
103* FOXO3_23340844_ChIP-Seq_DLD1_Human0.83016189
104BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.82333708
105ESR1_20079471_ChIP-ChIP_T-47D_Human0.82041912
106ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.81236071
107AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.81023896
108RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.80280760
109PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.80051186
110RARA_24833708_ChIP-Seq_LIVER_Mouse0.79886482
111SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.77592531
112BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.77056634
113PPAR_26484153_Chip-Seq_NCI-H1993_Human0.76524788
114ELK3_25401928_ChIP-Seq_HUVEC_Human0.76288303
115* ATF3_27146783_Chip-Seq_COLON_Human0.75643016
116ESR1_21235772_ChIP-Seq_MCF-7_Human0.73529757
117BCOR_27268052_Chip-Seq_Bcells_Human0.73351865
118KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.73118951
119SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.72680933
120MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.71874331
121SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.71702949
122CREB1_26743006_Chip-Seq_LNCaP_Human0.70932041
123RAD21_21589869_ChIP-Seq_MESCs_Mouse0.70014940
124ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.69362582
125CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.68400525
126TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.68033282
127TRIM28_21343339_ChIP-Seq_HEK293_Human0.67826558
128TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.67341807
129P68_20966046_ChIP-Seq_HELA_Human0.66741247
130DNAJC2_21179169_ChIP-ChIP_NT2_Human0.66038963
131BCL6_27268052_Chip-Seq_Bcells_Human0.65896288
132GATA1_22383799_ChIP-Seq_G1ME_Mouse0.65743434
133VDR_21846776_ChIP-Seq_THP-1_Human0.65532865
134EGR1_19032775_ChIP-ChIP_M12_Human0.65095543
135BRD4_27068464_Chip-Seq_AML-cells_Mouse0.65060727
136RARB_24833708_ChIP-Seq_LIVER_Mouse0.64067704
137SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.63977207
138SOX2_20726797_ChIP-Seq_SW620_Human0.63701458
139* CTCF_21964334_ChIP-Seq_BJAB-B_Human0.62095654
140* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.62044782
141P300_27058665_Chip-Seq_ZR-75-30cells_Human0.61862772
142PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.61327393
143MYC_19915707_ChIP-ChIP_AK7_Human0.61312037
144GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.61219715
145E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.61108582
146AUTS2_25519132_ChIP-Seq_293T-REX_Human0.60387569
147* TET1_21451524_ChIP-Seq_MESCs_Mouse0.59993018
148CEBPB_22108803_ChIP-Seq_LS180_Human0.59943918
149KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.58192510
150SALL4_18804426_ChIP-ChIP_XEN_Mouse0.58086762

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.41374987
2MP0005360_urolithiasis6.92680233
3MP0005085_abnormal_gallbladder_physiolo5.37305672
4MP0008875_abnormal_xenobiotic_pharmacok5.23097663
5MP0005365_abnormal_bile_salt5.08079473
6MP0003806_abnormal_nucleotide_metabolis3.55376979
7MP0002822_catalepsy3.50823172
8MP0003252_abnormal_bile_duct3.22760117
9MP0010329_abnormal_lipoprotein_level3.22214434
10MP0009840_abnormal_foam_cell3.09644316
11MP0003191_abnormal_cellular_cholesterol3.01719226
12MP0005083_abnormal_biliary_tract2.91454711
13MP0003283_abnormal_digestive_organ2.85151954
14MP0001666_abnormal_nutrient_absorption2.62085195
15MP0005332_abnormal_amino_acid2.53023984
16MP0003195_calcinosis2.27136969
17MP0004019_abnormal_vitamin_homeostasis2.24745194
18MP0005377_hearing/vestibular/ear_phenot2.02437960
19MP0003878_abnormal_ear_physiology2.02437960
20MP0000609_abnormal_liver_physiology2.02010845
21MP0002118_abnormal_lipid_homeostasis2.00315635
22MP0003705_abnormal_hypodermis_morpholog1.99943762
23MP0002138_abnormal_hepatobiliary_system1.97569386
24MP0005167_abnormal_blood-brain_barrier1.70765804
25MP0000566_synostosis1.68804642
26MP0005319_abnormal_enzyme/_coenzyme1.67817742
27MP0009379_abnormal_foot_pigmentation1.65373758
28MP0003656_abnormal_erythrocyte_physiolo1.60765778
29MP0009643_abnormal_urine_homeostasis1.56648548
30MP0005584_abnormal_enzyme/coenzyme_acti1.55814600
31MP0003868_abnormal_feces_composition1.51791867
32MP0003718_maternal_effect1.45563402
33MP0008872_abnormal_physiological_respon1.37644375
34MP0000678_abnormal_parathyroid_gland1.35689634
35MP0005451_abnormal_body_composition1.25071174
36MP0005636_abnormal_mineral_homeostasis1.22322111
37MP0003186_abnormal_redox_activity1.20197841
38MP0004130_abnormal_muscle_cell1.15995918
39MP0005670_abnormal_white_adipose1.15734044
40MP0010234_abnormal_vibrissa_follicle1.15299949
41MP0002132_abnormal_respiratory_system1.14822002
42MP0002249_abnormal_larynx_morphology1.13134859
43MP0001764_abnormal_homeostasis1.07445124
44MP0000598_abnormal_liver_morphology1.07104545
45MP0002653_abnormal_ependyma_morphology1.03186235
46MP0004858_abnormal_nervous_system1.00451306
47MP0001664_abnormal_digestion0.99510374
48MP0000538_abnormal_urinary_bladder0.98459094
49MP0001873_stomach_inflammation0.95251128
50MP0003646_muscle_fatigue0.94877427
51MP0000604_amyloidosis0.93250542
52MP0009384_cardiac_valve_regurgitation0.93028288
53MP0009333_abnormal_splenocyte_physiolog0.90421376
54MP0002254_reproductive_system_inflammat0.88550123
55MP0004043_abnormal_pH_regulation0.87537010
56MP0005666_abnormal_adipose_tissue0.87140083
57MP0002089_abnormal_postnatal_growth/wei0.86831600
58MP0001756_abnormal_urination0.86248419
59MP0005647_abnormal_sex_gland0.85364899
60MP0006036_abnormal_mitochondrial_physio0.85064755
61MP0005645_abnormal_hypothalamus_physiol0.83602343
62MP0005397_hematopoietic_system_phenotyp0.82227424
63MP0001545_abnormal_hematopoietic_system0.82227424
64MP0003300_gastrointestinal_ulcer0.81503311
65MP0000467_abnormal_esophagus_morphology0.77407699
66MP0009642_abnormal_blood_homeostasis0.77202167
67MP0003693_abnormal_embryo_hatching0.76972365
68MP0009763_increased_sensitivity_to0.74925255
69MP0002971_abnormal_brown_adipose0.74267571
70MP0009764_decreased_sensitivity_to0.73763713
71MP0003329_amyloid_beta_deposits0.73368620
72MP0004185_abnormal_adipocyte_glucose0.71942129
73MP0002837_dystrophic_cardiac_calcinosis0.71110632
74MP0002796_impaired_skin_barrier0.70835995
75MP0008469_abnormal_protein_level0.70755847
76MP0000462_abnormal_digestive_system0.70492355
77MP0003011_delayed_dark_adaptation0.70127776
78MP0001765_abnormal_ion_homeostasis0.69598320
79MP0002078_abnormal_glucose_homeostasis0.69127704
80MP0002136_abnormal_kidney_physiology0.67967344
81MP0005334_abnormal_fat_pad0.66745867
82MP0000003_abnormal_adipose_tissue0.66592303
83MP0003879_abnormal_hair_cell0.65956238
84MP0010155_abnormal_intestine_physiology0.64677405
85MP0002098_abnormal_vibrissa_morphology0.64276078
86MP0003075_altered_response_to0.63659079
87MP0003183_abnormal_peptide_metabolism0.61806544
88MP0008873_increased_physiological_sensi0.58471462
89MP0003866_abnormal_defecation0.58371797
90MP0009765_abnormal_xenobiotic_induced0.58220451
91MP0002938_white_spotting0.57297590
92MP0001727_abnormal_embryo_implantation0.57268867
93MP0003690_abnormal_glial_cell0.56641146
94MP0005376_homeostasis/metabolism_phenot0.56572788
95MP0000490_abnormal_crypts_of0.56075393
96MP0005266_abnormal_metabolism0.54985795
97MP0005395_other_phenotype0.54654929
98MP0005058_abnormal_lysosome_morphology0.53856116
99MP0005220_abnormal_exocrine_pancreas0.52988891
100MP0005084_abnormal_gallbladder_morpholo0.52952392
101MP0005166_decreased_susceptibility_to0.52350206
102MP0000681_abnormal_thyroid_gland0.52191133
103MP0005535_abnormal_body_temperature0.51339623
104MP0001661_extended_life_span0.51188971
105MP0002909_abnormal_adrenal_gland0.51038045
106MP0009053_abnormal_anal_canal0.50296867
107MP0010368_abnormal_lymphatic_system0.49999353
108MP0000013_abnormal_adipose_tissue0.49938724
109MP0005448_abnormal_energy_balance0.48273118
110MP0004264_abnormal_extraembryonic_tissu0.46080936
111MP0005375_adipose_tissue_phenotype0.44192469
112MP0005381_digestive/alimentary_phenotyp0.43919332
113MP0004147_increased_porphyrin_level0.43687863
114MP0006035_abnormal_mitochondrial_morpho0.43346274
115MP0009115_abnormal_fat_cell0.42050624
116MP0002269_muscular_atrophy0.41195016
117MP0000230_abnormal_systemic_arterial0.40804818
118MP0004947_skin_inflammation0.40773439
119MP0009672_abnormal_birth_weight0.40197687
120MP0005464_abnormal_platelet_physiology0.38991101
121MP0002060_abnormal_skin_morphology0.38538262
122MP0003638_abnormal_response/metabolism_0.38515157
123MP0003953_abnormal_hormone_level0.38089980
124MP0008961_abnormal_basal_metabolism0.37956960
125MP0000249_abnormal_blood_vessel0.37854148
126MP0009697_abnormal_copulation0.37368867
127MP0001663_abnormal_digestive_system0.36702971
128MP0008874_decreased_physiological_sensi0.36116213
129MP0000477_abnormal_intestine_morphology0.36083907
130MP0004782_abnormal_surfactant_physiolog0.35567119
131MP0002876_abnormal_thyroid_physiology0.34989493
132MP0002970_abnormal_white_adipose0.33155330

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.19856586
2Intrahepatic cholestasis (HP:0001406)6.11123220
3Abnormality of aromatic amino acid family metabolism (HP:0004338)6.04726586
4Abnormality of monocarboxylic acid metabolism (HP:0010996)5.64001112
5Xanthomatosis (HP:0000991)5.53026636
6Hypobetalipoproteinemia (HP:0003563)5.11472074
7Prolonged partial thromboplastin time (HP:0003645)4.78106768
8Hyperammonemia (HP:0001987)4.54355046
9Hyperlipoproteinemia (HP:0010980)4.51876405
10Complement deficiency (HP:0004431)4.36296571
11Hypolipoproteinemia (HP:0010981)4.19998497
12Ketosis (HP:0001946)4.18039551
13Abnormality of glutamine family amino acid metabolism (HP:0010902)4.12225811
14Hyperglycinuria (HP:0003108)4.04943940
15Hypoalphalipoproteinemia (HP:0003233)3.99481824
16Cerebral palsy (HP:0100021)3.91318768
17Abnormality of sulfur amino acid metabolism (HP:0004339)3.89610397
18Abnormality of serine family amino acid metabolism (HP:0010894)3.85449090
19Abnormality of glycine metabolism (HP:0010895)3.85449090
20Hyperglycinemia (HP:0002154)3.82456094
21Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.77524645
22Joint hemorrhage (HP:0005261)3.64860086
23Hypoglycemic coma (HP:0001325)3.64623538
24Epidermoid cyst (HP:0200040)3.64263938
25Abnormality of aspartate family amino acid metabolism (HP:0010899)3.58623223
26Abnormality of fatty-acid metabolism (HP:0004359)3.52709718
27Gout (HP:0001997)3.52041563
28Abnormality of the common coagulation pathway (HP:0010990)3.46438797
29Fat malabsorption (HP:0002630)3.36870182
30Abnormality of complement system (HP:0005339)3.32619743
31Ketoacidosis (HP:0001993)3.24666332
32Abnormality of methionine metabolism (HP:0010901)3.21916681
33Abnormality of purine metabolism (HP:0004352)3.20299652
34Hyperbilirubinemia (HP:0002904)3.15135676
35Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.14693709
36Abnormality of nucleobase metabolism (HP:0010932)3.07502343
37Dicarboxylic aciduria (HP:0003215)2.96702959
38Abnormality of dicarboxylic acid metabolism (HP:0010995)2.96702959
39Hypercholesterolemia (HP:0003124)2.86862462
40Metabolic acidosis (HP:0001942)2.86712903
41Abnormality of the intrinsic pathway (HP:0010989)2.85023455
42Hepatic necrosis (HP:0002605)2.84201082
43Abnormality of urine glucose concentration (HP:0011016)2.83973947
44Glycosuria (HP:0003076)2.83973947
45Abnormality of pyrimidine metabolism (HP:0004353)2.81907726
46Ileus (HP:0002595)2.80335276
47Hepatocellular carcinoma (HP:0001402)2.77795612
48Abnormal cartilage morphology (HP:0002763)2.75146096
49Cholelithiasis (HP:0001081)2.74760979
50Glomerulonephritis (HP:0000099)2.73833072
51Myocardial infarction (HP:0001658)2.72767272
52Abnormal gallbladder morphology (HP:0012437)2.64533872
53Acanthocytosis (HP:0001927)2.60315739
54Lethargy (HP:0001254)2.57694984
55Hyperuricemia (HP:0002149)2.57530880
56Increased purine levels (HP:0004368)2.57530880
57Delayed CNS myelination (HP:0002188)2.56802944
58Sensorimotor neuropathy (HP:0007141)2.55986631
59Nausea (HP:0002018)2.53667085
60Hepatocellular necrosis (HP:0001404)2.52444997
61Neonatal onset (HP:0003623)2.50905581
62Abnormality of serum amino acid levels (HP:0003112)2.50575844
63Increased serum ferritin (HP:0003281)2.49668483
64Steatorrhea (HP:0002570)2.49643935
65Spastic diplegia (HP:0001264)2.48975396
66Acute encephalopathy (HP:0006846)2.48921346
67Late onset (HP:0003584)2.48061050
68Increased muscle lipid content (HP:0009058)2.47112587
69Conjugated hyperbilirubinemia (HP:0002908)2.45552928
70Hypochromic microcytic anemia (HP:0004840)2.42877001
71Poikilocytosis (HP:0004447)2.39112857
72Cupped ribs (HP:0000887)2.38946050
73Cholecystitis (HP:0001082)2.38130970
74Abnormal gallbladder physiology (HP:0012438)2.38130970
75Malnutrition (HP:0004395)2.37072851
76Esophageal varix (HP:0002040)2.34876394
77Abnormal number of erythroid precursors (HP:0012131)2.33993295
78Vascular calcification (HP:0004934)2.33056117
79Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.28804112
80Abnormality of alanine metabolism (HP:0010916)2.28804112
81Hyperalaninemia (HP:0003348)2.28804112
82Skin nodule (HP:0200036)2.21804640
83Spontaneous abortion (HP:0005268)2.19876848
84Purpura (HP:0000979)2.19745362
85Cerebral edema (HP:0002181)2.19032493
86Vomiting (HP:0002013)2.18291006
87Nephrolithiasis (HP:0000787)2.16559678
88Reticulocytosis (HP:0001923)2.16524523
89Abnormality of the gallbladder (HP:0005264)2.15017576
90Flat acetabular roof (HP:0003180)2.14756919
91Polycythemia (HP:0001901)2.14333909
92Widely patent fontanelles and sutures (HP:0004492)2.13761685
93Petechiae (HP:0000967)2.12867493
94Abnormality of proline metabolism (HP:0010907)2.11506985
95Hydroxyprolinuria (HP:0003080)2.11506985
96Irritability (HP:0000737)2.10779686
97Stridor (HP:0010307)2.08711012
98Generalized aminoaciduria (HP:0002909)2.08290695
99Cardiovascular calcification (HP:0011915)2.07933383
100Alkalosis (HP:0001948)2.07260434
101Lactic acidosis (HP:0003128)2.06683544
102Systemic lupus erythematosus (HP:0002725)2.06614579
103Abnormality of the heme biosynthetic pathway (HP:0010472)2.05684660
104Nephritis (HP:0000123)2.05364933
105Myoglobinuria (HP:0002913)2.03422310
106Mitochondrial inheritance (HP:0001427)2.03169490
107Abnormality of cells of the erythroid lineage (HP:0012130)2.01795536
108Pancreatitis (HP:0001733)1.99433127
109Mesangial abnormality (HP:0001966)1.99177343
110Decreased circulating renin level (HP:0003351)1.98193194
111Hypoglycemic seizures (HP:0002173)1.97742248
112Abnormal mitochondria in muscle tissue (HP:0008316)1.97343376
113Hyperphosphaturia (HP:0003109)1.96274822
114Increased serum lactate (HP:0002151)1.95839687
115Increased neuronal autofluorescent lipopigment (HP:0002074)1.95028477
116Right ventricular cardiomyopathy (HP:0011663)1.93759865
117Menorrhagia (HP:0000132)1.93617421
118Reduced antithrombin III activity (HP:0001976)1.93577796
119Abnormality of iron homeostasis (HP:0011031)1.92532034
120Absent phalangeal crease (HP:0006109)1.92208281
121Rickets (HP:0002748)1.91895797
122Mitral stenosis (HP:0001718)1.91410092
123Increased serum pyruvate (HP:0003542)1.90870684
124Microretrognathia (HP:0000308)1.90786271
125Abnormality of the Achilles tendon (HP:0005109)1.90566902
126Opisthotonus (HP:0002179)1.90564497
127Potter facies (HP:0002009)1.90419637
128Facial shape deformation (HP:0011334)1.90419637
129Increased intramyocellular lipid droplets (HP:0012240)1.90346578
130Abnormality of the 1st metacarpal (HP:0010009)1.89365619
131Enlarged kidneys (HP:0000105)1.89018128
132Abnormality of transition element cation homeostasis (HP:0011030)1.88673462
133Hypertriglyceridemia (HP:0002155)1.84580787
134Wide cranial sutures (HP:0010537)1.83729861
135Amyloidosis (HP:0011034)1.83661152
136Hemorrhage of the eye (HP:0011885)1.83124968
137Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.81132928
138Proximal tubulopathy (HP:0000114)1.79215694
139Back pain (HP:0003418)1.78345971
140Increased CSF lactate (HP:0002490)1.78273561
141Abnormality of vitamin metabolism (HP:0100508)1.77968714
142Rhabdomyolysis (HP:0003201)1.77657447
143Abnormal enzyme/coenzyme activity (HP:0012379)1.76406527

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R6.59254647
2BCKDK5.13872815
3VRK24.60181758
4ERN13.76339088
5TRIB33.34545291
6PKN23.33860544
7PIM23.33823580
8SIK13.05462248
9PIK3CA2.96311462
10FGFR42.80769416
11MET2.59517925
12SMG12.37374502
13EPHA22.31458665
14ZAK2.25627558
15TESK22.18330367
16TLK12.15199982
17ACVR1B2.06448404
18MAPKAPK32.04808913
19MAP4K21.81930192
20PTK61.75485876
21ERBB41.69940886
22MAP2K21.63561880
23NUAK11.62963852
24MAP2K41.59880357
25MAP3K101.59049813
26GRK61.47911656
27MAP3K111.43707089
28MAPK111.42154143
29EEF2K1.40369526
30FLT31.39390540
31IRAK31.39207049
32VRK11.38798582
33TIE11.38580490
34EPHB11.35562976
35GRK11.28411580
36WNK41.27297682
37STK161.26799858
38TESK11.23313360
39MAP3K71.22262202
40TAOK31.19550762
41MUSK1.18348474
42NME11.14099643
43BUB11.12529280
44TTN1.12497561
45NEK11.11365638
46ICK1.10764867
47ADRBK21.10212545
48ILK1.09448547
49RIPK11.06445344
50CAMK1D0.95495104
51KSR20.95048892
52JAK20.94424802
53CSNK1G30.90386940
54MAPKAPK50.90153726
55DYRK20.90007700
56MAP2K10.89311504
57PIK3CG0.89216286
58TYK20.88910286
59FRK0.86307286
60CDK80.85102384
61RPS6KA50.83014069
62TBK10.82883584
63DAPK10.82287488
64MAP2K30.81492557
65LMTK20.80761694
66PDPK10.80081798
67DAPK20.79639366
68CSK0.78787960
69EPHB20.77829885
70LRRK20.77581286
71DYRK1B0.76182111
72CDK60.75275921
73LATS10.75263641
74PRKAA20.72901811
75INSRR0.72557676
76BMPR1B0.72463002
77BMX0.72067656
78AURKA0.71331681
79RPS6KA60.69283421
80ABL20.68760034
81MAP3K10.68759452
82FGFR20.68354413
83CHEK20.67857567
84ERBB20.67745527
85CDK190.66238138
86RET0.64724281
87CSNK1A1L0.64401466
88NME20.63862921
89PDGFRA0.63611169
90NEK90.63507398
91PTK20.63413839
92IKBKB0.62443860
93MAP3K120.61999663
94DAPK30.61361186
95PDK10.61201236
96MAP2K60.59749600
97TAOK20.58845855
98MAPK120.58401912
99MAP3K20.58003761
100TAOK10.57966486
101PRKCI0.57918813
102CDK90.57791253
103PDK30.57658123
104PDK40.57658123
105PRKAA10.57138804
106MYLK0.56673812
107PAK40.55854666
108KDR0.55246508
109GSK3A0.55076779
110RPS6KL10.54841717
111RPS6KC10.54841717
112MAP3K80.52677180
113TGFBR20.52549544
114ARAF0.52141286
115JAK10.51449749
116MAPK40.50727540
117CDK70.50639941
118LIMK10.49908191
119MTOR0.48467246
120PRKACG0.48436258
121PHKG20.48323288
122PHKG10.48323288
123CDK40.47048622
124CSNK1G10.45485015
125KIT0.44441194
126DDR20.44242058
127MAP3K30.42452035
128CAMK1G0.42385926
129PRKCZ0.42378253
130RPS6KA20.42110229
131CAMK2G0.41350387
132MAP3K40.41172534
133PRKCH0.40930561
134MATK0.40641716
135SGK30.40406907
136CSNK2A10.40250001
137FGFR30.40055473
138TNK20.39606708
139PRKG20.39149833
140ADRBK10.37966514
141MAP4K10.36915885
142STK390.36835651
143PRKCA0.35474283
144CSNK1G20.34119805
145BRAF0.33531987
146MAPKAPK20.33337804
147PIM10.32956147
148RPS6KB20.32653723
149CSNK1A10.32142520
150PINK10.31977835
151EPHA40.31800760
152WNK30.31185053
153NEK20.31041161
154EPHA30.30560111
155CAMK2D0.27676553
156STK100.27515855
157AKT20.27292673

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.83198385
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.38245267
3Nitrogen metabolism_Homo sapiens_hsa009103.33466707
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.12157941
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.77296115
6Fatty acid degradation_Homo sapiens_hsa000712.77276809
7Arginine biosynthesis_Homo sapiens_hsa002202.76985028
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.68839194
9Butanoate metabolism_Homo sapiens_hsa006502.66784093
10Tryptophan metabolism_Homo sapiens_hsa003802.60946146
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.51089125
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.36305060
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.32638809
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.26302813
15Complement and coagulation cascades_Homo sapiens_hsa046102.15421606
16Propanoate metabolism_Homo sapiens_hsa006402.10633276
17PPAR signaling pathway_Homo sapiens_hsa033202.06481716
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.03363495
19Fatty acid metabolism_Homo sapiens_hsa012122.00582709
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.99535618
21Peroxisome_Homo sapiens_hsa041461.93907102
22Chemical carcinogenesis_Homo sapiens_hsa052041.90446597
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.82732447
24* Sulfur metabolism_Homo sapiens_hsa009201.77232569
25Histidine metabolism_Homo sapiens_hsa003401.77145929
26beta-Alanine metabolism_Homo sapiens_hsa004101.66154003
27Bile secretion_Homo sapiens_hsa049761.65598917
28Steroid hormone biosynthesis_Homo sapiens_hsa001401.61508085
29Pyruvate metabolism_Homo sapiens_hsa006201.53943315
30Caffeine metabolism_Homo sapiens_hsa002321.53742041
31Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.50101723
32Phenylalanine metabolism_Homo sapiens_hsa003601.44866910
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.44546917
34Selenocompound metabolism_Homo sapiens_hsa004501.42185854
35Carbon metabolism_Homo sapiens_hsa012001.41593878
36Fat digestion and absorption_Homo sapiens_hsa049751.39717073
37Retinol metabolism_Homo sapiens_hsa008301.37624203
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.34076958
39Starch and sucrose metabolism_Homo sapiens_hsa005001.28857363
40Biosynthesis of amino acids_Homo sapiens_hsa012301.28478397
41Staphylococcus aureus infection_Homo sapiens_hsa051501.26687960
42Tyrosine metabolism_Homo sapiens_hsa003501.23048778
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.21770623
44Renin-angiotensin system_Homo sapiens_hsa046141.18864934
45Fatty acid elongation_Homo sapiens_hsa000621.15862080
46* Cysteine and methionine metabolism_Homo sapiens_hsa002701.13501601
47ABC transporters_Homo sapiens_hsa020101.10695518
48Cyanoamino acid metabolism_Homo sapiens_hsa004601.09641400
49Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.05560749
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.03569879
51Folate biosynthesis_Homo sapiens_hsa007901.02883770
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.00049445
53* Sulfur relay system_Homo sapiens_hsa041220.97158878
54Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.96497264
55Vitamin B6 metabolism_Homo sapiens_hsa007500.93902194
56Arginine and proline metabolism_Homo sapiens_hsa003300.93103293
57Glycerolipid metabolism_Homo sapiens_hsa005610.86751178
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.85410302
59Lysine degradation_Homo sapiens_hsa003100.84254343
60Steroid biosynthesis_Homo sapiens_hsa001000.80198984
61Maturity onset diabetes of the young_Homo sapiens_hsa049500.79273941
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.75781374
63Pentose phosphate pathway_Homo sapiens_hsa000300.75341140
64Glutathione metabolism_Homo sapiens_hsa004800.74240469
65Vitamin digestion and absorption_Homo sapiens_hsa049770.69427901
66Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.68968895
67Fructose and mannose metabolism_Homo sapiens_hsa000510.67476434
68Fatty acid biosynthesis_Homo sapiens_hsa000610.62288601
69Pyrimidine metabolism_Homo sapiens_hsa002400.61011312
70Base excision repair_Homo sapiens_hsa034100.59705755
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54298924
72Other glycan degradation_Homo sapiens_hsa005110.54156041
73alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.52311952
74Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49902165
75Ribosome_Homo sapiens_hsa030100.47071494
76Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.47012098
77Ether lipid metabolism_Homo sapiens_hsa005650.46605248
78Galactose metabolism_Homo sapiens_hsa000520.46506387
79* Metabolic pathways_Homo sapiens_hsa011000.44237158
80Linoleic acid metabolism_Homo sapiens_hsa005910.39159288
81One carbon pool by folate_Homo sapiens_hsa006700.38568217
82Insulin resistance_Homo sapiens_hsa049310.36444733
83Adipocytokine signaling pathway_Homo sapiens_hsa049200.35542569
84Prion diseases_Homo sapiens_hsa050200.35189987
85Proteasome_Homo sapiens_hsa030500.33534318
86DNA replication_Homo sapiens_hsa030300.32786118
87N-Glycan biosynthesis_Homo sapiens_hsa005100.28671638
88Huntingtons disease_Homo sapiens_hsa050160.27204085
89Mineral absorption_Homo sapiens_hsa049780.25569074
90RNA polymerase_Homo sapiens_hsa030200.22077619
91Alzheimers disease_Homo sapiens_hsa050100.21903046
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.21560681
93Homologous recombination_Homo sapiens_hsa034400.21503655
94Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.20585404
95Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.19895507
96Purine metabolism_Homo sapiens_hsa002300.18925363
97Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.15908718
98AMPK signaling pathway_Homo sapiens_hsa041520.13252215
99Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.12747965
100Bladder cancer_Homo sapiens_hsa052190.12579945
101Glucagon signaling pathway_Homo sapiens_hsa049220.09803565
102Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.07564263
103Central carbon metabolism in cancer_Homo sapiens_hsa052300.05649252
104Insulin signaling pathway_Homo sapiens_hsa049100.05249339
105Amoebiasis_Homo sapiens_hsa05146-0.1572178
106Parkinsons disease_Homo sapiens_hsa05012-0.1569286
107Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1536090
108Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.1462263
109Oxidative phosphorylation_Homo sapiens_hsa00190-0.1450754
110Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1432533
111Protein digestion and absorption_Homo sapiens_hsa04974-0.1331422
112Hepatitis C_Homo sapiens_hsa05160-0.1155799
113Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1128712
114Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1124979
115Thyroid cancer_Homo sapiens_hsa05216-0.1103983
116Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0735361
117Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0652076

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