MPPED1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.98655126
2vocalization behavior (GO:0071625)5.92433149
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.80124632
4synaptic vesicle maturation (GO:0016188)5.79550024
5locomotory exploration behavior (GO:0035641)5.76702401
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.74696934
7synaptic vesicle exocytosis (GO:0016079)5.60563179
8glutamate secretion (GO:0014047)5.47586019
9synaptic vesicle docking involved in exocytosis (GO:0016081)5.47411626
10protein localization to synapse (GO:0035418)5.41484644
11regulation of glutamate receptor signaling pathway (GO:1900449)5.33522554
12positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.30460071
13layer formation in cerebral cortex (GO:0021819)5.15472496
14neuron cell-cell adhesion (GO:0007158)5.05960222
15cellular potassium ion homeostasis (GO:0030007)4.99351299
16exploration behavior (GO:0035640)4.98314900
17regulation of synaptic vesicle exocytosis (GO:2000300)4.97302498
18gamma-aminobutyric acid transport (GO:0015812)4.88373412
19ionotropic glutamate receptor signaling pathway (GO:0035235)4.82558796
20sodium ion export (GO:0071436)4.80565001
21dendritic spine morphogenesis (GO:0060997)4.61531252
22positive regulation of synapse maturation (GO:0090129)4.59533214
23regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.59039709
24regulation of synaptic vesicle transport (GO:1902803)4.58214316
25regulation of long-term neuronal synaptic plasticity (GO:0048169)4.53349723
26regulation of neuronal synaptic plasticity (GO:0048168)4.51714995
27pyrimidine nucleobase catabolic process (GO:0006208)4.39724283
28neurotransmitter-gated ion channel clustering (GO:0072578)4.39290407
29neuron recognition (GO:0008038)4.37038526
30glutamate receptor signaling pathway (GO:0007215)4.35092139
31L-amino acid import (GO:0043092)4.32607362
32neurotransmitter secretion (GO:0007269)4.29492550
33synaptic transmission, glutamatergic (GO:0035249)4.29052139
34proline transport (GO:0015824)4.24921299
35regulation of synapse structural plasticity (GO:0051823)4.23340531
36central nervous system projection neuron axonogenesis (GO:0021952)4.15745778
37regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.07083299
38regulation of dendritic spine morphogenesis (GO:0061001)4.03386462
39axonal fasciculation (GO:0007413)4.02323046
40postsynaptic membrane organization (GO:0001941)4.01073051
41G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.96465216
42neuron-neuron synaptic transmission (GO:0007270)3.92732003
43regulation of voltage-gated calcium channel activity (GO:1901385)3.91830014
44negative regulation of dendrite morphogenesis (GO:0050774)3.91499055
45nucleobase catabolic process (GO:0046113)3.90677069
46long-term memory (GO:0007616)3.89858589
47amino acid import (GO:0043090)3.88594941
48regulation of excitatory postsynaptic membrane potential (GO:0060079)3.86048488
49positive regulation of membrane potential (GO:0045838)3.82411215
50cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.80775172
51dendrite morphogenesis (GO:0048813)3.80564815
52cell migration in hindbrain (GO:0021535)3.74936380
53synaptic vesicle endocytosis (GO:0048488)3.74189618
54neuronal ion channel clustering (GO:0045161)3.72568900
55neuronal action potential propagation (GO:0019227)3.72222912
56negative regulation of dendrite development (GO:2000171)3.69942080
57regulation of synaptic plasticity (GO:0048167)3.66881312
58regulation of postsynaptic membrane potential (GO:0060078)3.66330990
59positive regulation of dendritic spine morphogenesis (GO:0061003)3.59623864
60regulation of synapse maturation (GO:0090128)3.58456093
61presynaptic membrane assembly (GO:0097105)3.56031270
62membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.53774752
63regulation of dendritic spine development (GO:0060998)3.53456235
64positive regulation of neurotransmitter secretion (GO:0001956)3.51329473
65membrane depolarization during action potential (GO:0086010)3.49927220
66negative regulation of synaptic transmission, GABAergic (GO:0032229)3.47280588
67activation of protein kinase A activity (GO:0034199)3.45917588
68positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.45848908
69dendritic spine organization (GO:0097061)3.43623430
70regulation of neurotransmitter secretion (GO:0046928)3.41369996
71positive regulation of dendritic spine development (GO:0060999)3.41085207
72neurotransmitter transport (GO:0006836)3.37930227
73synapse assembly (GO:0007416)3.37378444
74central nervous system myelination (GO:0022010)3.36908227
75axon ensheathment in central nervous system (GO:0032291)3.36908227
76long-term synaptic potentiation (GO:0060291)3.34076387
77cerebellar Purkinje cell differentiation (GO:0021702)3.31953402
78presynaptic membrane organization (GO:0097090)3.31248661
79gamma-aminobutyric acid signaling pathway (GO:0007214)3.30621862
80cellular sodium ion homeostasis (GO:0006883)3.30214289
81cerebral cortex radially oriented cell migration (GO:0021799)3.29890161
82regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.27395923
83central nervous system neuron axonogenesis (GO:0021955)3.25808064
84cell communication by electrical coupling (GO:0010644)3.24597066
85potassium ion homeostasis (GO:0055075)3.23688691
86neuromuscular process controlling balance (GO:0050885)3.22861606
87potassium ion import (GO:0010107)3.21667407
88behavioral fear response (GO:0001662)3.20673104
89behavioral defense response (GO:0002209)3.20673104
90positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.19496892
91regulation of vesicle fusion (GO:0031338)3.19090037
92regulation of synaptic transmission, glutamatergic (GO:0051966)3.18657603
93transmission of nerve impulse (GO:0019226)3.15922507
94clathrin coat assembly (GO:0048268)3.14605347
95regulation of female receptivity (GO:0045924)3.13522093
96synaptic transmission (GO:0007268)3.13335180
97mitochondrion transport along microtubule (GO:0047497)3.13332568
98establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.13332568
99innervation (GO:0060384)3.12839822
100learning (GO:0007612)3.11674031
101cerebellar granule cell differentiation (GO:0021707)3.10881246
102positive regulation of neurotransmitter transport (GO:0051590)3.10798570
103regulation of neurotransmitter levels (GO:0001505)3.09112457
104auditory behavior (GO:0031223)3.08748022
105positive regulation of dendrite development (GO:1900006)3.08133233
106organelle transport along microtubule (GO:0072384)3.07481064
107positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.07045622
108regulation of dendrite morphogenesis (GO:0048814)3.06994099
109regulation of neurotransmitter transport (GO:0051588)3.06585846
110establishment of mitochondrion localization (GO:0051654)3.05322484
111regulation of dendrite development (GO:0050773)3.04368125
112startle response (GO:0001964)3.03201708
113G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.02912137
114synapse organization (GO:0050808)2.99875983
115fear response (GO:0042596)2.98844446
116establishment of synaptic vesicle localization (GO:0097480)2.97179235
117synaptic vesicle transport (GO:0048489)2.97179235
118intraspecies interaction between organisms (GO:0051703)2.96770688
119social behavior (GO:0035176)2.96770688
120axon extension (GO:0048675)2.95673122
121membrane depolarization (GO:0051899)2.95168160
122regulation of synaptic transmission (GO:0050804)2.94472037
123vesicle transport along microtubule (GO:0047496)2.92706816
124positive regulation of synaptic transmission, GABAergic (GO:0032230)2.90734633
125response to histamine (GO:0034776)2.90446661

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.17488643
2GBX2_23144817_ChIP-Seq_PC3_Human3.70975385
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.14030877
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.10739027
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.92961452
6* REST_21632747_ChIP-Seq_MESCs_Mouse2.85757617
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.67656523
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.67656523
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.61942636
10RARB_27405468_Chip-Seq_BRAIN_Mouse2.61499057
11* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.56664435
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.55860475
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.47011489
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.46827685
15DROSHA_22980978_ChIP-Seq_HELA_Human2.46715353
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.44997627
17* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.41830991
18EZH2_27294783_Chip-Seq_ESCs_Mouse2.29292590
19* REST_18959480_ChIP-ChIP_MESCs_Mouse2.24798640
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.23425205
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.22248977
22* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.20317547
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.15089528
24EED_16625203_ChIP-ChIP_MESCs_Mouse2.13608270
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.07898376
26AR_21572438_ChIP-Seq_LNCaP_Human1.99931480
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.86954302
28EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.84948162
29IKZF1_21737484_ChIP-ChIP_HCT116_Human1.83504314
30MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.78985066
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.77054174
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.69513533
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.67379428
34ZNF274_21170338_ChIP-Seq_K562_Hela1.65876252
35THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.61913415
36SMAD4_21799915_ChIP-Seq_A2780_Human1.59743376
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.56861475
38SMAD_19615063_ChIP-ChIP_OVARY_Human1.54522460
39ERG_21242973_ChIP-ChIP_JURKAT_Human1.52435002
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.49734479
41* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42810929
42TAF15_26573619_Chip-Seq_HEK293_Human1.39813915
43IGF1R_20145208_ChIP-Seq_DFB_Human1.37562913
44* SOX2_21211035_ChIP-Seq_LN229_Gbm1.36505883
45* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.34716671
46SMAD3_21741376_ChIP-Seq_EPCs_Human1.33905806
47RING1B_27294783_Chip-Seq_ESCs_Mouse1.33848654
48P300_19829295_ChIP-Seq_ESCs_Human1.33255208
49NR3C1_23031785_ChIP-Seq_PC12_Mouse1.31779993
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.29985022
51RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.27709538
52* AR_25329375_ChIP-Seq_VCAP_Human1.25575232
53RING1B_27294783_Chip-Seq_NPCs_Mouse1.23512219
54OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23434038
55P53_22127205_ChIP-Seq_FIBROBLAST_Human1.22243940
56PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.21809070
57* AR_19668381_ChIP-Seq_PC3_Human1.21507495
58TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18820388
59SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18517540
60TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16067303
61WT1_25993318_ChIP-Seq_PODOCYTE_Human1.15550228
62STAT3_23295773_ChIP-Seq_U87_Human1.15031237
63RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.14988926
64WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.14458863
65ZFP281_18757296_ChIP-ChIP_E14_Mouse1.13187709
66DNAJC2_21179169_ChIP-ChIP_NT2_Human1.12084757
67YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09794779
68PRDM14_20953172_ChIP-Seq_ESCs_Human1.09670631
69ARNT_22903824_ChIP-Seq_MCF-7_Human1.09400587
70VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.07722356
71KDM2B_26808549_Chip-Seq_K562_Human1.06774761
72TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05971653
73GATA1_26923725_Chip-Seq_HPCs_Mouse1.05173305
74TCF4_23295773_ChIP-Seq_U87_Human1.05037367
75TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.05000176
76RNF2_27304074_Chip-Seq_NSC_Mouse1.04575396
77ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04507194
78TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03983154
79POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03983154
80POU3F2_20337985_ChIP-ChIP_501MEL_Human1.03394479
81FUS_26573619_Chip-Seq_HEK293_Human1.02468545
82PIAS1_25552417_ChIP-Seq_VCAP_Human1.02342503
83LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01453774
84TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01141431
85ZFP281_27345836_Chip-Seq_ESCs_Mouse1.00219984
86* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.99778683
87ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.99365263
88AHR_22903824_ChIP-Seq_MCF-7_Human0.99173552
89SMAD3_21741376_ChIP-Seq_HESCs_Human0.99053474
90BMI1_23680149_ChIP-Seq_NPCS_Mouse0.98960767
91MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97723880
92MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97718716
93AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96085432
94RUNX2_22187159_ChIP-Seq_PCA_Human0.95900302
95SOX9_26525672_Chip-Seq_HEART_Mouse0.95588569
96TP53_16413492_ChIP-PET_HCT116_Human0.95361913
97CTCF_27219007_Chip-Seq_Bcells_Human0.94622017
98GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94450069
99* SMAD4_21741376_ChIP-Seq_HESCs_Human0.93981605
100TET1_21490601_ChIP-Seq_MESCs_Mouse0.93412000
101SMAD3_21741376_ChIP-Seq_ESCs_Human0.92913431
102OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.92891992
103UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92697948
104TP53_18474530_ChIP-ChIP_U2OS_Human0.92643416
105JUN_21703547_ChIP-Seq_K562_Human0.92377273
106NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92127118
107KDM2B_26808549_Chip-Seq_REH_Human0.90877733
108PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.89585508
109TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.88791465
110RBPJ_22232070_ChIP-Seq_NCS_Mouse0.88170358
111CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88149067
112SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.88015561
113CDX2_19796622_ChIP-Seq_MESCs_Mouse0.87991498
114TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.87738815
115CTNNB1_20460455_ChIP-Seq_HCT116_Human0.87257491
116TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87254764
117CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.85145442
118NANOG_18555785_Chip-Seq_ESCs_Mouse0.83697087
119FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.81730006

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.20207534
2MP0003880_abnormal_central_pattern4.72841745
3MP0003635_abnormal_synaptic_transmissio4.32690597
4MP0004270_analgesia4.23173364
5MP0002063_abnormal_learning/memory/cond3.63293335
6MP0009745_abnormal_behavioral_response3.38874451
7MP0002064_seizures3.01283272
8MP0001968_abnormal_touch/_nociception3.00548531
9MP0002572_abnormal_emotion/affect_behav2.82775180
10MP0002734_abnormal_mechanical_nocicepti2.76241304
11MP0005423_abnormal_somatic_nervous2.69916043
12MP0009046_muscle_twitch2.64625653
13MP0000778_abnormal_nervous_system2.58458449
14MP0002736_abnormal_nociception_after2.45599881
15MP0001486_abnormal_startle_reflex2.40256201
16MP0009780_abnormal_chondrocyte_physiolo2.37263696
17MP0002735_abnormal_chemical_nociception2.32498125
18MP0000569_abnormal_digit_pigmentation2.23753775
19MP0002272_abnormal_nervous_system2.18743830
20MP0001440_abnormal_grooming_behavior2.14747496
21MP0003329_amyloid_beta_deposits2.08240316
22MP0002733_abnormal_thermal_nociception2.05497050
23MP0002184_abnormal_innervation1.99457502
24MP0004811_abnormal_neuron_physiology1.99304034
25MP0001501_abnormal_sleep_pattern1.98982696
26MP0004858_abnormal_nervous_system1.96676011
27MP0001970_abnormal_pain_threshold1.88788489
28MP0002557_abnormal_social/conspecific_i1.82107259
29MP0003879_abnormal_hair_cell1.78657763
30MP0002067_abnormal_sensory_capabilities1.76598297
31MP0004924_abnormal_behavior1.72834623
32MP0005386_behavior/neurological_phenoty1.72834623
33MP0003787_abnormal_imprinting1.70369244
34MP0000955_abnormal_spinal_cord1.69186066
35MP0008569_lethality_at_weaning1.65984454
36MP0002822_catalepsy1.65409395
37MP0004885_abnormal_endolymph1.53798536
38MP0002909_abnormal_adrenal_gland1.50477927
39MP0005646_abnormal_pituitary_gland1.49681228
40MP0002882_abnormal_neuron_morphology1.46600769
41MP0002066_abnormal_motor_capabilities/c1.41068631
42MP0006276_abnormal_autonomic_nervous1.34777378
43MP0000920_abnormal_myelination1.33982686
44MP0003690_abnormal_glial_cell1.31248479
45MP0002152_abnormal_brain_morphology1.28452610
46MP0001984_abnormal_olfaction1.26826452
47MP0003633_abnormal_nervous_system1.21159356
48MP0001905_abnormal_dopamine_level1.18260163
49MP0001529_abnormal_vocalization1.12983174
50MP0003631_nervous_system_phenotype1.08827832
51MP0001188_hyperpigmentation1.08546219
52MP0005645_abnormal_hypothalamus_physiol1.01606739
53MP0001502_abnormal_circadian_rhythm1.00158853
54MP0001177_atelectasis0.99626281
55MP0002069_abnormal_eating/drinking_beha0.98769942
56MP0002234_abnormal_pharynx_morphology0.98443004
57MP0000631_abnormal_neuroendocrine_gland0.95415901
58MP0000604_amyloidosis0.93354106
59MP0003123_paternal_imprinting0.90896793
60MP0002876_abnormal_thyroid_physiology0.86636593
61MP0006292_abnormal_olfactory_placode0.86412215
62MP0000751_myopathy0.86196280
63MP0004142_abnormal_muscle_tone0.84480473
64MP0010386_abnormal_urinary_bladder0.83751586
65MP0003861_abnormal_nervous_system0.83686885
66MP0002638_abnormal_pupillary_reflex0.83451433
67MP0004510_myositis0.82624730
68MP0005499_abnormal_olfactory_system0.82400772
69MP0005394_taste/olfaction_phenotype0.82400772
70MP0005187_abnormal_penis_morphology0.82216695
71MP0001963_abnormal_hearing_physiology0.81315045
72MP0008877_abnormal_DNA_methylation0.79465961
73MP0003632_abnormal_nervous_system0.79401483
74MP0001986_abnormal_taste_sensitivity0.79040858
75MP0004085_abnormal_heartbeat0.78678331
76MP0002249_abnormal_larynx_morphology0.78046796
77MP0002229_neurodegeneration0.76399912
78MP0001346_abnormal_lacrimal_gland0.76155819
79MP0002837_dystrophic_cardiac_calcinosis0.75692959
80MP0000566_synostosis0.75641515
81MP0004147_increased_porphyrin_level0.74458668
82MP0008874_decreased_physiological_sensi0.74037348
83MP0003119_abnormal_digestive_system0.73407072
84MP0001485_abnormal_pinna_reflex0.73312023
85MP0002752_abnormal_somatic_nervous0.73044871
86MP0008872_abnormal_physiological_respon0.72560518
87MP0003634_abnormal_glial_cell0.71028481
88MP0005535_abnormal_body_temperature0.70558898
89MP0003137_abnormal_impulse_conducting0.69770822
90MP0001664_abnormal_digestion0.68269988
91MP0004742_abnormal_vestibular_system0.66862354
92MP0003075_altered_response_to0.66828331
93MP0000015_abnormal_ear_pigmentation0.66387646
94MP0003283_abnormal_digestive_organ0.65914055
95MP0004484_altered_response_of0.64922469
96MP0002090_abnormal_vision0.64659125
97MP0010234_abnormal_vibrissa_follicle0.62114635
98MP0004130_abnormal_muscle_cell0.61611141
99MP0005551_abnormal_eye_electrophysiolog0.60567821
100MP0010770_preweaning_lethality0.60306398
101MP0002082_postnatal_lethality0.60306398
102MP0003122_maternal_imprinting0.59160039
103MP0002102_abnormal_ear_morphology0.58984668
104MP0010768_mortality/aging0.58444180
105MP0000026_abnormal_inner_ear0.57834231
106MP0004145_abnormal_muscle_electrophysio0.57168865
107MP0003938_abnormal_ear_development0.56646065
108MP0008961_abnormal_basal_metabolism0.55694276
109MP0001348_abnormal_lacrimal_gland0.55624190
110MP0005409_darkened_coat_color0.55515901
111MP0010769_abnormal_survival0.55314993
112MP0004215_abnormal_myocardial_fiber0.55196585
113MP0004233_abnormal_muscle_weight0.55025158
114MP0001943_abnormal_respiration0.54897176
115MP0003172_abnormal_lysosome_physiology0.54470571
116MP0003121_genomic_imprinting0.54399727
117MP0003956_abnormal_body_size0.49933677
118MP0000579_abnormal_nail_morphology0.46069402
119MP0002081_perinatal_lethality0.45788695

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.97947857
2Myokymia (HP:0002411)6.59004680
3Focal seizures (HP:0007359)5.20527831
4Visual hallucinations (HP:0002367)5.19268237
5Epileptic encephalopathy (HP:0200134)5.04483927
6Hyperventilation (HP:0002883)4.29284800
7Broad-based gait (HP:0002136)4.01778025
8Atonic seizures (HP:0010819)3.92378304
9Mutism (HP:0002300)3.84685471
10Febrile seizures (HP:0002373)3.83640217
11Poor eye contact (HP:0000817)3.74401374
12Supranuclear gaze palsy (HP:0000605)3.70840122
13Progressive cerebellar ataxia (HP:0002073)3.70541566
14Absence seizures (HP:0002121)3.61559872
15Generalized tonic-clonic seizures (HP:0002069)3.57273330
16Amyotrophic lateral sclerosis (HP:0007354)3.42151836
17Excessive salivation (HP:0003781)3.37386536
18Drooling (HP:0002307)3.37386536
19Cerebral inclusion bodies (HP:0100314)3.32058388
20Impaired vibration sensation in the lower limbs (HP:0002166)3.31850679
21Ankle clonus (HP:0011448)3.31785758
22Dialeptic seizures (HP:0011146)3.27817976
23Papilledema (HP:0001085)3.24469725
24Abnormal social behavior (HP:0012433)3.23977020
25Impaired social interactions (HP:0000735)3.23977020
26Abnormality of the lower motor neuron (HP:0002366)3.17729753
27Obstructive sleep apnea (HP:0002870)3.12884962
28Neurofibrillary tangles (HP:0002185)3.09576956
29Amblyopia (HP:0000646)3.07059642
30Urinary bladder sphincter dysfunction (HP:0002839)3.00606323
31Progressive inability to walk (HP:0002505)2.99910259
32Action tremor (HP:0002345)2.94893570
33Depression (HP:0000716)2.94751761
34Abnormality of binocular vision (HP:0011514)2.91388519
35Diplopia (HP:0000651)2.91388519
36Epileptiform EEG discharges (HP:0011182)2.90807380
37Absent speech (HP:0001344)2.90499013
38Abnormal eating behavior (HP:0100738)2.86481230
39Gaze-evoked nystagmus (HP:0000640)2.84715247
40Abnormality of the corticospinal tract (HP:0002492)2.83983732
41EEG with generalized epileptiform discharges (HP:0011198)2.79838430
42Inability to walk (HP:0002540)2.77122733
43Urinary urgency (HP:0000012)2.73041585
44Hypsarrhythmia (HP:0002521)2.72095100
45Limb dystonia (HP:0002451)2.71868881
46Hemiplegia (HP:0002301)2.68137863
47Focal dystonia (HP:0004373)2.67237448
48Torticollis (HP:0000473)2.66767141
49Anxiety (HP:0000739)2.66612224
50Tetraplegia (HP:0002445)2.65894619
51Stereotypic behavior (HP:0000733)2.64278326
52Akinesia (HP:0002304)2.63501414
53Hemiparesis (HP:0001269)2.63278994
54Cerebral hypomyelination (HP:0006808)2.61523769
55Insidious onset (HP:0003587)2.59146546
56Termporal pattern (HP:0011008)2.59146546
57Dysmetria (HP:0001310)2.58353573
58Inappropriate behavior (HP:0000719)2.57728613
59Truncal ataxia (HP:0002078)2.55534210
60Clonus (HP:0002169)2.53026826
61Dysdiadochokinesis (HP:0002075)2.51381020
62Genetic anticipation (HP:0003743)2.51001641
63Polyphagia (HP:0002591)2.48017020
64Megalencephaly (HP:0001355)2.47708056
65Fetal akinesia sequence (HP:0001989)2.45006902
66Spastic gait (HP:0002064)2.43322200
67Neuronal loss in central nervous system (HP:0002529)2.42960275
68Postural instability (HP:0002172)2.34967506
69Impaired smooth pursuit (HP:0007772)2.34396211
70Aplasia/Hypoplasia of the brainstem (HP:0007362)2.32563689
71Hypoplasia of the brainstem (HP:0002365)2.32563689
72Bradykinesia (HP:0002067)2.28860031
73Craniofacial dystonia (HP:0012179)2.28771704
74Protruding tongue (HP:0010808)2.26192424
75Abnormality of salivation (HP:0100755)2.22450775
76Scanning speech (HP:0002168)2.22367836
77Split foot (HP:0001839)2.21431199
78Apathy (HP:0000741)2.18720463
79Thickened helices (HP:0000391)2.17744200
80Generalized myoclonic seizures (HP:0002123)2.16188903
81Intention tremor (HP:0002080)2.15015498
82Sleep apnea (HP:0010535)2.13459988
83Lower limb muscle weakness (HP:0007340)2.12776133
84Impaired vibratory sensation (HP:0002495)2.12681815
85Pachygyria (HP:0001302)2.11744822
86Insomnia (HP:0100785)2.07685400
87Generalized hypopigmentation of hair (HP:0011358)2.07394313
88Annular pancreas (HP:0001734)2.05790736
89Morphological abnormality of the pyramidal tract (HP:0002062)2.05597555
90Delusions (HP:0000746)2.02715298
91Lower limb asymmetry (HP:0100559)2.02345281
92Degeneration of the lateral corticospinal tracts (HP:0002314)2.02026333
93Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.02026333
94Blue irides (HP:0000635)2.00949780
95Hepatoblastoma (HP:0002884)1.98165598
96Fair hair (HP:0002286)1.97546479
97Spastic tetraparesis (HP:0001285)1.97447523
98Lissencephaly (HP:0001339)1.95904706
99Abnormality of ocular smooth pursuit (HP:0000617)1.95436431
100Large eyes (HP:0001090)1.94625008
101Gastroesophageal reflux (HP:0002020)1.93469498
102Pointed chin (HP:0000307)1.93462129
103Diminished motivation (HP:0000745)1.91428986
104Status epilepticus (HP:0002133)1.89120422
105Abnormality of the labia minora (HP:0012880)1.88535355
106Agitation (HP:0000713)1.87163228
107Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.86306685
108Hypoplasia of the corpus callosum (HP:0002079)1.85150402
109Intellectual disability, severe (HP:0010864)1.82702914
110Intellectual disability, profound (HP:0002187)1.82223402
111Gait ataxia (HP:0002066)1.82101861
112Peripheral hypomyelination (HP:0007182)1.81846253
113Incomplete penetrance (HP:0003829)1.81836632
114Spastic tetraplegia (HP:0002510)1.79578863
115Rigidity (HP:0002063)1.78524123
116Lower limb amyotrophy (HP:0007210)1.77605418
117Gait imbalance (HP:0002141)1.76623298
118Choreoathetosis (HP:0001266)1.75470698
119Memory impairment (HP:0002354)1.73178221
120Prolonged QT interval (HP:0001657)1.70988150
121Abnormality of the periventricular white matter (HP:0002518)1.67613894
122Deeply set eye (HP:0000490)1.67468936
123Dyskinesia (HP:0100660)1.67033953
124CNS hypomyelination (HP:0003429)1.66959909

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.41528851
2EPHA44.20211468
3MAP3K93.73497665
4NTRK33.54027182
5CASK2.98715332
6DAPK22.94233332
7MAP3K42.85100440
8MINK12.77881190
9MAP2K72.64716704
10NTRK22.08419854
11PAK62.07662599
12DAPK11.85237644
13KSR21.75044328
14SIK21.74232978
15PLK21.70837414
16PRKD31.69757899
17CAMKK11.67980357
18KSR11.66483333
19MAPK131.65661912
20MAP2K41.64860231
21RIPK41.62154581
22MAP3K121.60341618
23CDK51.59319063
24LATS21.44494563
25PHKG21.41132497
26PHKG11.41132497
27NTRK11.30473573
28TNIK1.27915178
29PRKCG1.26745201
30GRK51.21292296
31CDK191.20509748
32PRPF4B1.16812563
33PNCK1.15970968
34TYRO31.15529074
35DYRK21.07293640
36CSNK1G21.05078289
37CCNB11.00974305
38TAOK11.00745436
39FES0.94471292
40CDK180.93804138
41CDK150.92902717
42STK110.89903779
43CAMK40.89688294
44MAP3K20.89246019
45UHMK10.89125887
46CAMK2A0.88720490
47STK380.87490264
48CDK140.87487474
49DYRK1A0.87001939
50CDK11A0.80341383
51RET0.80025912
52SCYL20.78731820
53MARK20.77573068
54PTK2B0.77408254
55ARAF0.74622373
56ERBB30.74155642
57MAP3K60.73058977
58RAF10.70996783
59PRKCZ0.70366040
60FGR0.70319700
61SGK4940.68089319
62SGK2230.68089319
63PRKCH0.66403436
64PAK30.65048348
65BMPR20.64478548
66ALK0.64009263
67CAMK2B0.64003563
68ICK0.63664005
69NEK60.61711060
70CAMK10.61461070
71NME10.61095061
72MAPK120.59350632
73SGK10.59117535
74CAMK1G0.56459614
75SGK20.56246687
76IRAK20.54433051
77CAMK2G0.54348050
78MAP3K130.52265303
79PRKCE0.50175085
80PINK10.49700222
81OXSR10.49406101
82PDK10.49072936
83RPS6KA20.48876212
84MAP3K70.48772074
85PKN10.48310591
86SGK30.48054907
87FER0.46551482
88RIPK10.45857259
89FYN0.44583406
90DAPK30.43954114
91FGFR20.42448759
92PDPK10.42040022
93CAMKK20.39498381
94CAMK1D0.39404081
95BRSK10.39031419
96BRAF0.39023651
97RPS6KA30.38633888
98MAP2K10.36719535
99CSNK1G30.35132354
100MAPK80.33722354
101TNK20.33387427
102ROCK10.32024790
103CSNK1D0.31701950
104PRKCA0.31481898
105MAPK100.31218421
106GRK60.31198713
107MAPK40.31165613
108CSNK1A1L0.30786363
109MAP3K10.30029689
110DMPK0.30021769
111MAP3K110.29910632
112MAPK70.29501099
113ERBB20.29120763
114MAP2K60.28762042
115LMTK20.28295583
116GSK3B0.28073769
117PRKACA0.27689936
118ROCK20.27686022
119PRKCB0.27685345
120WNK30.27558669
121CAMK2D0.26962130
122FRK0.26494365
123PRKG10.26409453
124CSNK1E0.26242019
125LIMK10.25122484

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.60401440
2Synaptic vesicle cycle_Homo sapiens_hsa047213.19151732
3Circadian entrainment_Homo sapiens_hsa047132.80234966
4Long-term potentiation_Homo sapiens_hsa047202.74853317
5Olfactory transduction_Homo sapiens_hsa047402.70439933
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.69506282
7Glutamatergic synapse_Homo sapiens_hsa047242.67277013
8GABAergic synapse_Homo sapiens_hsa047272.64261199
9Morphine addiction_Homo sapiens_hsa050322.46629859
10Amphetamine addiction_Homo sapiens_hsa050312.43178532
11Dopaminergic synapse_Homo sapiens_hsa047282.26473595
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.20547559
13Salivary secretion_Homo sapiens_hsa049702.12440949
14Cholinergic synapse_Homo sapiens_hsa047251.93580610
15Insulin secretion_Homo sapiens_hsa049111.88528141
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.82835292
17Gastric acid secretion_Homo sapiens_hsa049711.82445521
18Renin secretion_Homo sapiens_hsa049241.75626112
19Taste transduction_Homo sapiens_hsa047421.74456656
20Serotonergic synapse_Homo sapiens_hsa047261.72201874
21Oxytocin signaling pathway_Homo sapiens_hsa049211.69820839
22Long-term depression_Homo sapiens_hsa047301.66662735
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.62798870
24Axon guidance_Homo sapiens_hsa043601.59323334
25Vitamin B6 metabolism_Homo sapiens_hsa007501.53813802
26Calcium signaling pathway_Homo sapiens_hsa040201.51974478
27GnRH signaling pathway_Homo sapiens_hsa049121.51015714
28Gap junction_Homo sapiens_hsa045401.46045302
29Cocaine addiction_Homo sapiens_hsa050301.42223564
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.35890012
31Collecting duct acid secretion_Homo sapiens_hsa049661.30772732
32Glioma_Homo sapiens_hsa052141.30763919
33Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.29897383
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.25619452
35Estrogen signaling pathway_Homo sapiens_hsa049151.24981200
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.24494382
37cAMP signaling pathway_Homo sapiens_hsa040241.21291810
38ErbB signaling pathway_Homo sapiens_hsa040121.21288270
39Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.14587297
40Type II diabetes mellitus_Homo sapiens_hsa049301.13019947
41Melanogenesis_Homo sapiens_hsa049161.12707262
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.08334541
43Oocyte meiosis_Homo sapiens_hsa041141.06329146
44Phosphatidylinositol signaling system_Homo sapiens_hsa040701.04248265
45cGMP-PKG signaling pathway_Homo sapiens_hsa040221.04052613
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.90062223
47Vascular smooth muscle contraction_Homo sapiens_hsa042700.86785067
48Choline metabolism in cancer_Homo sapiens_hsa052310.83466219
49Endometrial cancer_Homo sapiens_hsa052130.82851483
50VEGF signaling pathway_Homo sapiens_hsa043700.82787263
51Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.82692590
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81709246
53Vibrio cholerae infection_Homo sapiens_hsa051100.80908723
54Phospholipase D signaling pathway_Homo sapiens_hsa040720.79530935
55Phototransduction_Homo sapiens_hsa047440.79190854
56Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77568308
57Dorso-ventral axis formation_Homo sapiens_hsa043200.75741333
58Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.75239804
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.74420969
60Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.73042353
61MAPK signaling pathway_Homo sapiens_hsa040100.71632619
62Cardiac muscle contraction_Homo sapiens_hsa042600.71097877
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.70930447
64Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.70074714
65Ras signaling pathway_Homo sapiens_hsa040140.68103831
66Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65813867
67Pancreatic secretion_Homo sapiens_hsa049720.64848644
68Colorectal cancer_Homo sapiens_hsa052100.61604328
69Sphingolipid signaling pathway_Homo sapiens_hsa040710.61225335
70Wnt signaling pathway_Homo sapiens_hsa043100.61198852
71Dilated cardiomyopathy_Homo sapiens_hsa054140.61129988
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60476598
73Glucagon signaling pathway_Homo sapiens_hsa049220.59956259
74Rap1 signaling pathway_Homo sapiens_hsa040150.59172007
75Endocytosis_Homo sapiens_hsa041440.59126534
76Thyroid hormone synthesis_Homo sapiens_hsa049180.58697791
77Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55931422
78Renal cell carcinoma_Homo sapiens_hsa052110.55824267
79Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.55767974
80mTOR signaling pathway_Homo sapiens_hsa041500.54259454
81Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.52746382
82Non-small cell lung cancer_Homo sapiens_hsa052230.52685322
83Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51821193
84Alcoholism_Homo sapiens_hsa050340.49867144
85Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.48571073
86Arginine biosynthesis_Homo sapiens_hsa002200.46660456
87Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.46255437
88Insulin signaling pathway_Homo sapiens_hsa049100.44489832
89Prion diseases_Homo sapiens_hsa050200.44110484
90Histidine metabolism_Homo sapiens_hsa003400.44014976
91Circadian rhythm_Homo sapiens_hsa047100.42835833
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42467927
93Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39956983
94Type I diabetes mellitus_Homo sapiens_hsa049400.37825281
95Chemokine signaling pathway_Homo sapiens_hsa040620.37169717
96beta-Alanine metabolism_Homo sapiens_hsa004100.36155317
97Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.36103553
98Inositol phosphate metabolism_Homo sapiens_hsa005620.35971795
99Nitrogen metabolism_Homo sapiens_hsa009100.35768649
100African trypanosomiasis_Homo sapiens_hsa051430.35488933
101Bile secretion_Homo sapiens_hsa049760.34555443
102Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.33428474
103Regulation of actin cytoskeleton_Homo sapiens_hsa048100.31306273
104Butanoate metabolism_Homo sapiens_hsa006500.31213365
105Alzheimers disease_Homo sapiens_hsa050100.30985624
106Ovarian steroidogenesis_Homo sapiens_hsa049130.30878103
107Fatty acid biosynthesis_Homo sapiens_hsa000610.30729089
108SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28443975
109AMPK signaling pathway_Homo sapiens_hsa041520.26462532
110Arginine and proline metabolism_Homo sapiens_hsa003300.25548576
111Hippo signaling pathway_Homo sapiens_hsa043900.24272517
112Tight junction_Homo sapiens_hsa045300.22440535
113Mineral absorption_Homo sapiens_hsa049780.20008440
114Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.18300974
115Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.14472559

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