MPP6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Members of the peripheral membrane-associated guanylate kinase (MAGUK) family function in tumor suppression and receptor clustering by forming multiprotein complexes containing distinct sets of transmembrane, cytoskeletal, and cytoplasmic signaling proteins. All MAGUKs contain a PDZ-SH3-GUK core and are divided into 4 subfamilies, DLG-like (see DLG1; MIM 601014), ZO1-like (see TJP1; MIM 601009), p55-like (see MPP1; MIM 305360), and LIN2-like (see CASK; MIM 300172), based on their size and the presence of additional domains. MPP6 is a member of the p55-like MAGUK subfamily (Tseng et al., 2001 [PubMed 11311936]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1indolalkylamine catabolic process (GO:0046218)5.09833174
2tryptophan catabolic process (GO:0006569)5.09833174
3indole-containing compound catabolic process (GO:0042436)5.09833174
4aromatic amino acid family catabolic process (GO:0009074)4.92948687
5glyoxylate metabolic process (GO:0046487)4.90935109
6kynurenine metabolic process (GO:0070189)4.89622873
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.86724536
8cysteine metabolic process (GO:0006534)4.85953204
9urea metabolic process (GO:0019627)4.79029493
10urea cycle (GO:0000050)4.79029493
11tryptophan metabolic process (GO:0006568)4.75803419
12sulfur amino acid catabolic process (GO:0000098)4.63658390
13L-phenylalanine catabolic process (GO:0006559)4.55335597
14erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.55335597
15L-phenylalanine metabolic process (GO:0006558)4.53360578
16erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.53360578
17lysine catabolic process (GO:0006554)4.49612630
18lysine metabolic process (GO:0006553)4.49612630
19glycine metabolic process (GO:0006544)4.48084883
20water-soluble vitamin biosynthetic process (GO:0042364)4.42794723
21dicarboxylic acid biosynthetic process (GO:0043650)4.41221347
22serine family amino acid catabolic process (GO:0009071)4.41063316
23cellular glucuronidation (GO:0052695)4.38255627
24homocysteine metabolic process (GO:0050667)4.30296974
25nitrogen cycle metabolic process (GO:0071941)4.26468486
26amino-acid betaine metabolic process (GO:0006577)4.24586677
27bile acid biosynthetic process (GO:0006699)4.24395791
28fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.18203568
29low-density lipoprotein particle remodeling (GO:0034374)4.17793863
30alpha-linolenic acid metabolic process (GO:0036109)4.13824287
31serine family amino acid metabolic process (GO:0009069)4.08776178
32regulation of hexokinase activity (GO:1903299)4.05473253
33regulation of glucokinase activity (GO:0033131)4.05473253
34cellular ketone body metabolic process (GO:0046950)4.05073464
35serine family amino acid biosynthetic process (GO:0009070)4.03689868
36macromolecular complex remodeling (GO:0034367)4.02031811
37plasma lipoprotein particle remodeling (GO:0034369)4.02031811
38protein-lipid complex remodeling (GO:0034368)4.02031811
39high-density lipoprotein particle remodeling (GO:0034375)3.98165775
40complement activation, alternative pathway (GO:0006957)3.98102816
41regulation of protein activation cascade (GO:2000257)3.93990360
42negative regulation of sterol transport (GO:0032372)3.93635752
43negative regulation of cholesterol transport (GO:0032375)3.93635752
44negative regulation of fatty acid biosynthetic process (GO:0045717)3.91180972
45protein carboxylation (GO:0018214)3.91112105
46peptidyl-glutamic acid carboxylation (GO:0017187)3.91112105
47regulation of cholesterol esterification (GO:0010872)3.86565335
48negative regulation of fibrinolysis (GO:0051918)3.80749259
49alpha-amino acid catabolic process (GO:1901606)3.80303371
50inositol phosphate catabolic process (GO:0071545)3.77425794
51respiratory chain complex IV assembly (GO:0008535)3.75576291
52glutamate metabolic process (GO:0006536)3.73963418
53one-carbon metabolic process (GO:0006730)3.69106389
54uronic acid metabolic process (GO:0006063)3.67015578
55glucuronate metabolic process (GO:0019585)3.67015578
56tetrahydrofolate metabolic process (GO:0046653)3.64845120
57regulation of complement activation (GO:0030449)3.64334242
58imidazole-containing compound metabolic process (GO:0052803)3.63168194
59flavonoid metabolic process (GO:0009812)3.62220640
60folic acid-containing compound biosynthetic process (GO:0009396)3.60827477
61regulation of fibrinolysis (GO:0051917)3.59522968
62bile acid and bile salt transport (GO:0015721)3.57668741
63acylglycerol homeostasis (GO:0055090)3.54773625
64triglyceride homeostasis (GO:0070328)3.54773625
65NAD biosynthetic process (GO:0009435)3.54467889
66bile acid metabolic process (GO:0008206)3.54171527
67carnitine metabolic process (GO:0009437)3.53496351
68lactate metabolic process (GO:0006089)3.53055748
69nicotinamide nucleotide biosynthetic process (GO:0019359)3.52271513
70pyridine nucleotide biosynthetic process (GO:0019363)3.52271513
71ketone body metabolic process (GO:1902224)3.50461175
72inositol phosphate dephosphorylation (GO:0046855)3.48897501
73phosphorylated carbohydrate dephosphorylation (GO:0046838)3.48897501
74regulation of triglyceride catabolic process (GO:0010896)3.48455286
75cellular amino acid catabolic process (GO:0009063)3.47120032
76protein K6-linked ubiquitination (GO:0085020)3.46229488
77aromatic amino acid family metabolic process (GO:0009072)3.45801335
78reverse cholesterol transport (GO:0043691)3.45124165
79negative regulation of DNA-dependent DNA replication (GO:2000104)3.42517586
80amine catabolic process (GO:0009310)3.41462171
81cellular biogenic amine catabolic process (GO:0042402)3.41462171
82urate metabolic process (GO:0046415)3.41275918
83drug catabolic process (GO:0042737)3.38187874
84indolalkylamine metabolic process (GO:0006586)3.35489301
85regulation of type B pancreatic cell apoptotic process (GO:2000674)3.35321566
86phospholipid efflux (GO:0033700)3.33875243
87blood coagulation, intrinsic pathway (GO:0007597)3.33275536
88nuclear pore complex assembly (GO:0051292)3.32327298
89presynaptic membrane assembly (GO:0097105)3.30093553
90cytochrome complex assembly (GO:0017004)3.28509430
91negative regulation of fatty acid metabolic process (GO:0045922)3.27707205
92regulation of DNA endoreduplication (GO:0032875)3.25205556
93mitotic sister chromatid cohesion (GO:0007064)3.24147259
94positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.22102791
95positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.22102791
96positive regulation of mitotic sister chromatid separation (GO:1901970)3.22102791
97exogenous drug catabolic process (GO:0042738)3.17381401
98endocrine pancreas development (GO:0031018)3.17234167
992-oxoglutarate metabolic process (GO:0006103)3.15350329
100fructose metabolic process (GO:0006000)3.14743055
101aspartate family amino acid catabolic process (GO:0009068)3.13336249
102response to nitrosative stress (GO:0051409)3.12957870
103positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.11725396
104benzene-containing compound metabolic process (GO:0042537)3.11678667
105cellular modified amino acid catabolic process (GO:0042219)3.11216876
106positive regulation of protein autophosphorylation (GO:0031954)3.09821080
107drug transmembrane transport (GO:0006855)3.09611140
108ethanol oxidation (GO:0006069)3.08997441
109plasma lipoprotein particle assembly (GO:0034377)3.07627039
110tyrosine metabolic process (GO:0006570)3.06699199
111phospholipid homeostasis (GO:0055091)3.06019419
112negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.05174865
113plasma lipoprotein particle clearance (GO:0034381)3.04952331
114plasma lipoprotein particle organization (GO:0071827)3.04854371
115fatty acid transmembrane transport (GO:1902001)3.04785664
116nuclear pore organization (GO:0006999)3.04192061
117insulin secretion (GO:0030073)3.03232671
118protein prenylation (GO:0018342)3.02563815
119prenylation (GO:0097354)3.02563815
120polyol catabolic process (GO:0046174)2.99346064
121very-low-density lipoprotein particle assembly (GO:0034379)2.93281094
122negative regulation of hormone biosynthetic process (GO:0032353)2.93170795
123epithelial cell fate commitment (GO:0072148)2.92858027
124positive regulation of lipid catabolic process (GO:0050996)2.92336466
125fibrinolysis (GO:0042730)2.91548779
126pyridine-containing compound biosynthetic process (GO:0072525)2.91547681
127nitric oxide mediated signal transduction (GO:0007263)2.87514329
128DNA double-strand break processing (GO:0000729)2.85404298
129presynaptic membrane organization (GO:0097090)2.84344763
130positive regulation of glycolytic process (GO:0045821)2.83921407
131synapsis (GO:0007129)2.83053376
132protein complex biogenesis (GO:0070271)2.82284635
133signal peptide processing (GO:0006465)2.79208556
134glycerophospholipid catabolic process (GO:0046475)2.75217721
135single strand break repair (GO:0000012)2.71110801
136kidney morphogenesis (GO:0060993)2.70431579
137mitochondrial respiratory chain complex assembly (GO:0033108)2.70319480
138dentate gyrus development (GO:0021542)2.65638210
139regulation of nuclear cell cycle DNA replication (GO:0033262)2.65086023
140positive regulation of histone H3-K4 methylation (GO:0051571)2.63215620
141regulation of mitochondrial translation (GO:0070129)2.60660124
142positive regulation of meiosis (GO:0045836)2.57754048
143dorsal/ventral axis specification (GO:0009950)2.57154403
144negative regulation of protein oligomerization (GO:0032460)2.55117712
145regulation of meiosis I (GO:0060631)2.50007242
146negative regulation of cytosolic calcium ion concentration (GO:0051481)2.49843750
147rRNA methylation (GO:0031167)2.48773843
148detection of calcium ion (GO:0005513)2.47621296
149cullin deneddylation (GO:0010388)2.46670637
150chromatin remodeling at centromere (GO:0031055)2.46568707
151rRNA modification (GO:0000154)2.46435783
152replication fork processing (GO:0031297)2.45776054
153atrial cardiac muscle cell action potential (GO:0086014)2.45012363
154establishment of protein localization to mitochondrial membrane (GO:0090151)2.44815214
155positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.44085126
156histone exchange (GO:0043486)2.43356214
157prostate gland growth (GO:0060736)2.42795721
158establishment of protein localization to Golgi (GO:0072600)2.41877480
159negative regulation of membrane potential (GO:0045837)2.41618804
160positive regulation of meiotic cell cycle (GO:0051446)2.41431510
161positive regulation of peptide hormone secretion (GO:0090277)2.39852805
162negative regulation of hormone metabolic process (GO:0032351)2.39830517
163protein targeting to Golgi (GO:0000042)2.39795321
164negative regulation of neurological system process (GO:0031645)2.39704638
165positive regulation of insulin secretion (GO:0032024)2.37800337
166exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.35428258
167CENP-A containing nucleosome assembly (GO:0034080)2.35371836
168telomere maintenance via telomerase (GO:0007004)2.34934978
169regulation of mitotic spindle checkpoint (GO:1903504)2.34634177
170regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.34634177
171glandular epithelial cell differentiation (GO:0002067)2.33461779
172double-strand break repair via homologous recombination (GO:0000724)2.31928017
173positive regulation of chromosome segregation (GO:0051984)2.31595693
174recombinational repair (GO:0000725)2.30904115
175positive regulation of peptide secretion (GO:0002793)2.30491460
176signal transduction involved in regulation of gene expression (GO:0023019)2.30066274
177somite rostral/caudal axis specification (GO:0032525)2.28142443
178proteasome assembly (GO:0043248)2.27908873
179nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.27836810
180branched-chain amino acid catabolic process (GO:0009083)2.27522217
181mitochondrial respiratory chain complex I assembly (GO:0032981)2.25900587
182NADH dehydrogenase complex assembly (GO:0010257)2.25900587
183mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.25900587
184sister chromatid cohesion (GO:0007062)2.25589027
185keratinocyte development (GO:0003334)2.25180420
186negative regulation of gluconeogenesis (GO:0045721)2.21182129
187resolution of meiotic recombination intermediates (GO:0000712)2.21003477
188negative regulation of dendrite development (GO:2000171)2.20475729
189negative regulation of acute inflammatory response (GO:0002674)2.19680637
190mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.19546413
191righting reflex (GO:0060013)2.19135940
192protein deneddylation (GO:0000338)2.14914347
193regulation of protein glycosylation (GO:0060049)2.14860810
194somatic hypermutation of immunoglobulin genes (GO:0016446)2.14768656
195somatic diversification of immune receptors via somatic mutation (GO:0002566)2.14768656
196pituitary gland development (GO:0021983)2.14471415
197maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.13185107

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.73517601
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.52096284
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.87698785
4EGR1_23403033_ChIP-Seq_LIVER_Mouse4.63309202
5PPARA_22158963_ChIP-Seq_LIVER_Mouse4.36693701
6* LXR_22158963_ChIP-Seq_LIVER_Mouse3.69724284
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.29504171
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.14067718
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.87823903
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.86733222
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.77115038
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.69408069
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.69269114
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.66868030
15GBX2_23144817_ChIP-Seq_PC3_Human2.66034214
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.62933888
17FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.49962628
18FUS_26573619_Chip-Seq_HEK293_Human2.47978768
19ZFP57_27257070_Chip-Seq_ESCs_Mouse2.47208283
20KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.43347358
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.40496723
22ZNF274_21170338_ChIP-Seq_K562_Hela2.33276789
23IGF1R_20145208_ChIP-Seq_DFB_Human2.32633259
24AR_21909140_ChIP-Seq_LNCAP_Human2.27899776
25* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.24289099
26* EWS_26573619_Chip-Seq_HEK293_Human2.23446157
27TAF15_26573619_Chip-Seq_HEK293_Human2.23230968
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.19633925
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.14785696
30* P300_19829295_ChIP-Seq_ESCs_Human2.12045428
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.07360810
32FLI1_27457419_Chip-Seq_LIVER_Mouse2.06892805
33ESR1_15608294_ChIP-ChIP_MCF-7_Human2.02927986
34VDR_22108803_ChIP-Seq_LS180_Human2.00107126
35HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.98774212
36* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.95794801
37RBPJ_22232070_ChIP-Seq_NCS_Mouse1.93676617
38AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.91847997
39GABP_17652178_ChIP-ChIP_JURKAT_Human1.90101120
40IRF8_22096565_ChIP-ChIP_GC-B_Human1.89740641
41NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.88567285
42HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.85718718
43E2F1_21310950_ChIP-Seq_MCF-7_Human1.84830149
44TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82743145
45FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.78715310
46ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.77672677
47CTBP1_25329375_ChIP-Seq_LNCAP_Human1.71188979
48EST1_17652178_ChIP-ChIP_JURKAT_Human1.70602690
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.69335792
50MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.66455873
51SMAD4_21799915_ChIP-Seq_A2780_Human1.66216052
52* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.64167036
53KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.61175820
54PIAS1_25552417_ChIP-Seq_VCAP_Human1.60711777
55PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60219305
56PCGF2_27294783_Chip-Seq_ESCs_Mouse1.56636384
57* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.53837559
58SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52788505
59NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.51056794
60NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.50867748
61BCAT_22108803_ChIP-Seq_LS180_Human1.44862753
62ER_23166858_ChIP-Seq_MCF-7_Human1.44693157
63MYB_21317192_ChIP-Seq_ERMYB_Mouse1.43750523
64STAT3_1855785_ChIP-Seq_MESCs_Mouse1.43269987
65UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.42865715
66CBP_20019798_ChIP-Seq_JUKART_Human1.42363347
67IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42363347
68ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.42090353
69* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.41042466
70AR_25329375_ChIP-Seq_VCAP_Human1.39806668
71* STAT3_23295773_ChIP-Seq_U87_Human1.39616344
72OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39498744
73NELFA_20434984_ChIP-Seq_ESCs_Mouse1.38904511
74NANOG_18555785_Chip-Seq_ESCs_Mouse1.37921783
75SMAD3_21741376_ChIP-Seq_EPCs_Human1.37039557
76SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36985289
77Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.36661031
78TCF4_23295773_ChIP-Seq_U87_Human1.36552778
79TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.33258817
80TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.32688843
81EZH2_27294783_Chip-Seq_NPCs_Mouse1.32621545
82MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.31880437
83SUZ12_27294783_Chip-Seq_NPCs_Mouse1.31306150
84MYC_19079543_ChIP-ChIP_MESCs_Mouse1.31297327
85IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.31248506
86NOTCH1_21737748_ChIP-Seq_TLL_Human1.29142451
87NFE2_27457419_Chip-Seq_LIVER_Mouse1.26532132
88POU5F1_16153702_ChIP-ChIP_HESCs_Human1.25731177
89BMI1_23680149_ChIP-Seq_NPCS_Mouse1.24153066
90MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24058467
91TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23892546
92CLOCK_20551151_ChIP-Seq_293T_Human1.22486208
93PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.20605429
94BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.20009234
95TP53_22573176_ChIP-Seq_HFKS_Human1.18137919
96EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.18040640
97NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.17940234
98TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.17289923
99P53_22387025_ChIP-Seq_ESCs_Mouse1.17231603
100* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.17141909
101TCF4_22108803_ChIP-Seq_LS180_Human1.16983107
102SOX2_19829295_ChIP-Seq_ESCs_Human1.16155550
103NANOG_19829295_ChIP-Seq_ESCs_Human1.16155550
104GATA1_22025678_ChIP-Seq_K562_Human1.13333531
105HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.13224559
106CDX2_22108803_ChIP-Seq_LS180_Human1.13101984
107IRF8_21731497_ChIP-ChIP_J774_Mouse1.12866945
108KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12727598
109GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.12699670
110MYC_18358816_ChIP-ChIP_MESCs_Mouse1.11739392
111* IRF8_27001747_Chip-Seq_BMDM_Mouse1.10482235
112E2F1_18555785_Chip-Seq_ESCs_Mouse1.10342357
113EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09894618
114SUZ12_18555785_Chip-Seq_ESCs_Mouse1.08798538
115BRD4_27068464_Chip-Seq_AML-cells_Mouse1.08316517
116NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08259942
117CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.08117181
118CMYC_18555785_Chip-Seq_ESCs_Mouse1.07912575
119HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.07097099
120HNF4A_19822575_ChIP-Seq_HepG2_Human1.06570990
121RUNX2_22187159_ChIP-Seq_PCA_Human1.06414860
122FOXM1_26456572_ChIP-Seq_MCF-7_Human1.05598243
123FLI1_21867929_ChIP-Seq_TH2_Mouse1.05162368
124RNF2_27304074_Chip-Seq_NSC_Mouse1.04917251
125P300_18555785_Chip-Seq_ESCs_Mouse1.04899029
126CRX_20693478_ChIP-Seq_RETINA_Mouse1.04072609
127FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.03476661
128STAT3_18555785_Chip-Seq_ESCs_Mouse1.03011418
129TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01650872
130POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01650872
131SMAD4_21741376_ChIP-Seq_EPCs_Human0.99774345
132HTT_18923047_ChIP-ChIP_STHdh_Human0.99537619
133EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.98677122
134SOX2_18555785_Chip-Seq_ESCs_Mouse0.98296360
135EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.98178485
136ZFX_18555785_ChIP-Seq_MESCs_Mouse0.95635119
137FOXA1_27270436_Chip-Seq_PROSTATE_Human0.95361886
138FOXA1_25329375_ChIP-Seq_VCAP_Human0.95361886
139SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.92928420
140TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.92777680
141SCL_19346495_ChIP-Seq_HPC-7_Human0.92634047
142PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92523340
143CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.90890008
144MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.90837507
145FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.90161091
146ELK1_19687146_ChIP-ChIP_HELA_Human0.87863632
147HOXB4_20404135_ChIP-ChIP_EML_Mouse0.87857801
148IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.87353483
149STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.86535156
150SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.86177063
151MYC_22102868_ChIP-Seq_BL_Human0.83772531
152E2F1_18555785_ChIP-Seq_MESCs_Mouse0.82538208
153FOXA2_19822575_ChIP-Seq_HepG2_Human0.80421405
154BP1_19119308_ChIP-ChIP_Hs578T_Human0.79718069
155PADI4_21655091_ChIP-ChIP_MCF-7_Human0.78629204
156CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.76955975
157PU_27001747_Chip-Seq_BMDM_Mouse0.75665005
158GATA6_25053715_ChIP-Seq_YYC3_Human0.75508975
159GATA2_22383799_ChIP-Seq_G1ME_Mouse0.75441316
160SALL4_18804426_ChIP-ChIP_XEN_Mouse0.73765722
161SALL1_21062744_ChIP-ChIP_HESCs_Human0.73667829
162STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.72815562
163E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.72085329
164RXRA_24833708_ChIP-Seq_LIVER_Mouse0.70157878
165NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.69397323
166ZNF263_19887448_ChIP-Seq_K562_Human0.69052318
167* GATA4_25053715_ChIP-Seq_YYC3_Human0.68593666
168KLF4_18555785_ChIP-Seq_MESCs_Mouse0.67683807
169KDM5A_27292631_Chip-Seq_BREAST_Human0.67272518
170POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.66985881
171VDR_23849224_ChIP-Seq_CD4+_Human0.66448932
172* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.65823933
173SPI1_23547873_ChIP-Seq_NB4_Human0.64174923
174MYC_18940864_ChIP-ChIP_HL60_Human0.63788301
175FOXP3_21729870_ChIP-Seq_TREG_Human0.62926793
176NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.62368725
177RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.62001504
178* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.61393202
179* MYB_26560356_Chip-Seq_TH1_Human0.60888699
180PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.60137670
181POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.59601559
182SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.59099861
183XRN2_22483619_ChIP-Seq_HELA_Human0.58537100
184RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.58342090
185ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.57726106
186MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.57567392

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.73854693
2MP0005360_urolithiasis6.16435814
3MP0005085_abnormal_gallbladder_physiolo5.14600798
4MP0005365_abnormal_bile_salt4.74345886
5MP0003806_abnormal_nucleotide_metabolis3.86134521
6MP0008875_abnormal_xenobiotic_pharmacok3.70480506
7MP0003787_abnormal_imprinting3.65543053
8MP0003252_abnormal_bile_duct3.38710775
9MP0002837_dystrophic_cardiac_calcinosis3.10821119
10MP0010329_abnormal_lipoprotein_level2.73043637
11MP0010234_abnormal_vibrissa_follicle2.64149602
12MP0003283_abnormal_digestive_organ2.61195392
13MP0002138_abnormal_hepatobiliary_system2.51654893
14MP0006072_abnormal_retinal_apoptosis2.51293348
15MP0009780_abnormal_chondrocyte_physiolo2.27604527
16MP0005332_abnormal_amino_acid2.22798661
17MP0002163_abnormal_gland_morphology2.22453655
18MP0005379_endocrine/exocrine_gland_phen2.19514232
19MP0003121_genomic_imprinting2.10498387
20MP0003123_paternal_imprinting2.03701041
21MP0003122_maternal_imprinting2.01391195
22MP0009697_abnormal_copulation2.00157917
23MP0003705_abnormal_hypodermis_morpholog1.99963296
24MP0005645_abnormal_hypothalamus_physiol1.99853804
25MP0004019_abnormal_vitamin_homeostasis1.95590712
26MP0005083_abnormal_biliary_tract1.94189934
27MP0002102_abnormal_ear_morphology1.89368874
28MP0002909_abnormal_adrenal_gland1.87992824
29MP0005319_abnormal_enzyme/_coenzyme1.86697062
30MP0008058_abnormal_DNA_repair1.82993358
31MP0003693_abnormal_embryo_hatching1.82542965
32MP0001666_abnormal_nutrient_absorption1.81716260
33MP0000609_abnormal_liver_physiology1.80122278
34MP0010307_abnormal_tumor_latency1.80117162
35MP0009840_abnormal_foam_cell1.78414952
36MP0000013_abnormal_adipose_tissue1.71434735
37MP0001984_abnormal_olfaction1.70829044
38MP0005220_abnormal_exocrine_pancreas1.69542090
39MP0001944_abnormal_pancreas_morphology1.65673390
40MP0003890_abnormal_embryonic-extraembry1.64631766
41MP0002938_white_spotting1.64279650
42MP0003186_abnormal_redox_activity1.62737464
43MP0005646_abnormal_pituitary_gland1.62473416
44MP0010094_abnormal_chromosome_stability1.60100526
45MP0003191_abnormal_cellular_cholesterol1.58234933
46MP0009046_muscle_twitch1.56829237
47MP0005551_abnormal_eye_electrophysiolog1.55100903
48MP0006292_abnormal_olfactory_placode1.50033980
49MP0010352_gastrointestinal_tract_polyps1.48574623
50MP0002693_abnormal_pancreas_physiology1.44876148
51MP0005253_abnormal_eye_physiology1.44239957
52MP0004957_abnormal_blastocyst_morpholog1.42970150
53MP0000598_abnormal_liver_morphology1.41084725
54MP0003868_abnormal_feces_composition1.39648975
55MP0000631_abnormal_neuroendocrine_gland1.39226294
56MP0003718_maternal_effect1.36351298
57MP0000569_abnormal_digit_pigmentation1.34407571
58MP0002118_abnormal_lipid_homeostasis1.33848547
59MP0008057_abnormal_DNA_replication1.32815217
60MP0002272_abnormal_nervous_system1.30183495
61MP0002160_abnormal_reproductive_system1.30128934
62MP0010678_abnormal_skin_adnexa1.29334017
63MP0000516_abnormal_urinary_system1.28287453
64MP0005367_renal/urinary_system_phenotyp1.28287453
65MP0001764_abnormal_homeostasis1.27208898
66MP0003195_calcinosis1.26707606
67MP0002876_abnormal_thyroid_physiology1.25998544
68MP0005584_abnormal_enzyme/coenzyme_acti1.24329825
69MP0009745_abnormal_behavioral_response1.24317152
70MP0004215_abnormal_myocardial_fiber1.23134646
71MP0000427_abnormal_hair_cycle1.21509839
72MP0004270_analgesia1.19947066
73MP0002638_abnormal_pupillary_reflex1.19272815
74MP0001968_abnormal_touch/_nociception1.16444785
75MP0001485_abnormal_pinna_reflex1.16223155
76MP0003111_abnormal_nucleus_morphology1.15907517
77MP0002090_abnormal_vision1.15511263
78MP0001853_heart_inflammation1.15221638
79MP0003300_gastrointestinal_ulcer1.15098659
80MP0003119_abnormal_digestive_system1.13813087
81MP0001835_abnormal_antigen_presentation1.10605884
82MP0009643_abnormal_urine_homeostasis1.08896903
83MP0005389_reproductive_system_phenotype1.07548628
84MP0003567_abnormal_fetal_cardiomyocyte1.06943338
85MP0005167_abnormal_blood-brain_barrier1.06833022
86MP0009763_increased_sensitivity_to1.06484926
87MP0005266_abnormal_metabolism1.04278248
88MP0001188_hyperpigmentation1.01948980
89MP0002396_abnormal_hematopoietic_system1.00613173
90MP0005075_abnormal_melanosome_morpholog1.00120568
91MP0008872_abnormal_physiological_respon0.99359349
92MP0002736_abnormal_nociception_after0.99092698
93MP0003436_decreased_susceptibility_to0.98588055
94MP0003937_abnormal_limbs/digits/tail_de0.98449929
95MP0008469_abnormal_protein_level0.97483760
96MP0005464_abnormal_platelet_physiology0.95896686
97MP0003880_abnormal_central_pattern0.95659032
98MP0002254_reproductive_system_inflammat0.94020721
99MP0004885_abnormal_endolymph0.93001930
100MP0002751_abnormal_autonomic_nervous0.92696337
101MP0002234_abnormal_pharynx_morphology0.92471627
102MP0002557_abnormal_social/conspecific_i0.92114271
103MP0002078_abnormal_glucose_homeostasis0.91727780
104MP0005166_decreased_susceptibility_to0.90973624
105MP0005174_abnormal_tail_pigmentation0.90865059
106MP0004130_abnormal_muscle_cell0.90513422
107MP0003011_delayed_dark_adaptation0.89990636
108MP0004133_heterotaxia0.88188657
109MP0002064_seizures0.87946637
110MP0003077_abnormal_cell_cycle0.87792758
111MP0004924_abnormal_behavior0.86834233
112MP0005386_behavior/neurological_phenoty0.86834233
113MP0001929_abnormal_gametogenesis0.86356969
114MP0006036_abnormal_mitochondrial_physio0.84645344
115MP0003656_abnormal_erythrocyte_physiolo0.83781481
116MP0004808_abnormal_hematopoietic_stem0.81567547
117MP0009764_decreased_sensitivity_to0.81022575
118MP0005647_abnormal_sex_gland0.80696037
119MP0002572_abnormal_emotion/affect_behav0.80299761
120MP0001986_abnormal_taste_sensitivity0.79973334
121MP0003786_premature_aging0.79972343
122MP0001486_abnormal_startle_reflex0.79100193
123MP0006276_abnormal_autonomic_nervous0.78834376
124MP0000383_abnormal_hair_follicle0.78568652
125MP0001501_abnormal_sleep_pattern0.78496792
126MP0000653_abnormal_sex_gland0.77688617
127MP0002184_abnormal_innervation0.77627624
128MP0003303_peritoneal_inflammation0.77525814
129MP0001915_intracranial_hemorrhage0.76884153
130MP0003941_abnormal_skin_development0.76457768
131MP0002734_abnormal_mechanical_nocicepti0.76258372
132MP0002086_abnormal_extraembryonic_tissu0.75894978
133MP0002735_abnormal_chemical_nociception0.75798102
134MP0004264_abnormal_extraembryonic_tissu0.75407617
135MP0001730_embryonic_growth_arrest0.74517905
136MP0000647_abnormal_sebaceous_gland0.74402727
137MP0009672_abnormal_birth_weight0.74389627
138MP0001145_abnormal_male_reproductive0.74269525
139MP0001919_abnormal_reproductive_system0.73794882
140MP0002210_abnormal_sex_determination0.73360628
141MP0002233_abnormal_nose_morphology0.73009179
142MP0005376_homeostasis/metabolism_phenot0.72745077
143MP0004197_abnormal_fetal_growth/weight/0.72655585
144MP0010386_abnormal_urinary_bladder0.72312705
145MP0003075_altered_response_to0.71850201
146MP0000490_abnormal_crypts_of0.69088547
147MP0010155_abnormal_intestine_physiology0.67918763
148MP0005636_abnormal_mineral_homeostasis0.67670830
149MP0009765_abnormal_xenobiotic_induced0.67658414
150MP0009053_abnormal_anal_canal0.67322011
151MP0005451_abnormal_body_composition0.65805384
152MP0005025_abnormal_response_to0.63981753
153MP0002877_abnormal_melanocyte_morpholog0.63730071
154MP0008007_abnormal_cellular_replicative0.63531720
155MP0003984_embryonic_growth_retardation0.63262234
156MP0001845_abnormal_inflammatory_respons0.63260678
157MP0002088_abnormal_embryonic_growth/wei0.62923072
158MP0001672_abnormal_embryogenesis/_devel0.62754986
159MP0005380_embryogenesis_phenotype0.62754986
160MP0008877_abnormal_DNA_methylation0.61686150
161MP0002166_altered_tumor_susceptibility0.61566227
162MP0002019_abnormal_tumor_incidence0.61341624
163MP0009642_abnormal_blood_homeostasis0.60802588
164MP0001661_extended_life_span0.60595044
165MP0000689_abnormal_spleen_morphology0.60436293
166MP0002136_abnormal_kidney_physiology0.59961444
167MP0002089_abnormal_postnatal_growth/wei0.59714368
168MP0003646_muscle_fatigue0.59594359
169MP0008873_increased_physiological_sensi0.58722850
170MP0002006_tumorigenesis0.58188551
171MP0002282_abnormal_trachea_morphology0.57321284
172MP0002928_abnormal_bile_duct0.57158276
173MP0002419_abnormal_innate_immunity0.57003266
174MP0002269_muscular_atrophy0.56796037
175MP0005397_hematopoietic_system_phenotyp0.55064022
176MP0001545_abnormal_hematopoietic_system0.55064022
177MP0005076_abnormal_cell_differentiation0.53974380
178MP0005334_abnormal_fat_pad0.53367195
179MP0005084_abnormal_gallbladder_morpholo0.53044976
180MP0005377_hearing/vestibular/ear_phenot0.51415844
181MP0003878_abnormal_ear_physiology0.51415844
182MP0009785_altered_susceptibility_to0.51217028

Predicted human phenotypes

RankGene SetZ-score
1Hypobetalipoproteinemia (HP:0003563)5.85899398
2Intrahepatic cholestasis (HP:0001406)5.80814186
3Abnormality of monocarboxylic acid metabolism (HP:0010996)5.34467564
4Deep venous thrombosis (HP:0002625)4.99521511
5Hypoglycemic seizures (HP:0002173)4.78958113
6Hypolipoproteinemia (HP:0010981)4.67334420
7Prolonged partial thromboplastin time (HP:0003645)4.60423707
8Xanthomatosis (HP:0000991)4.57727998
9Hyperinsulinemic hypoglycemia (HP:0000825)4.54788578
10Abnormality of aromatic amino acid family metabolism (HP:0004338)4.23012745
11Hyperammonemia (HP:0001987)4.16943336
12Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.12485190
13Hypoalphalipoproteinemia (HP:0003233)4.10381368
14Abnormality of pyrimidine metabolism (HP:0004353)4.08206096
15Joint hemorrhage (HP:0005261)4.01579391
16Abnormality of methionine metabolism (HP:0010901)3.83452021
17Abnormality of sulfur amino acid metabolism (HP:0004339)3.75968702
18Abnormality of aspartate family amino acid metabolism (HP:0010899)3.74487288
19Hyperlipoproteinemia (HP:0010980)3.68809473
20Epidermoid cyst (HP:0200040)3.62433179
21Abnormality of glutamine family amino acid metabolism (HP:0010902)3.58134033
22Complement deficiency (HP:0004431)3.56641272
23Neoplasm of the adrenal cortex (HP:0100641)3.56164045
24Abnormality of endocrine pancreas physiology (HP:0012093)3.37619340
25Abnormality of the pancreatic islet cells (HP:0006476)3.37619340
26Symptomatic seizures (HP:0011145)3.21465664
27Abnormality of the common coagulation pathway (HP:0010990)3.18407781
28Hyperglycemia (HP:0003074)3.08585331
29Abnormality of nucleobase metabolism (HP:0010932)3.08522470
30Hypoglycemic coma (HP:0001325)3.07204998
31Abnormality of the intrinsic pathway (HP:0010989)3.06957353
32Hypochromic microcytic anemia (HP:0004840)3.04183052
33Spontaneous abortion (HP:0005268)3.03880500
34Ketosis (HP:0001946)3.02999466
35Fat malabsorption (HP:0002630)3.02884862
36Hepatocellular carcinoma (HP:0001402)2.96794155
37Abnormality of the labia minora (HP:0012880)2.96417432
38Pancreatic islet-cell hyperplasia (HP:0004510)2.93431785
39Abnormality of complement system (HP:0005339)2.92807078
40Hyperglycinuria (HP:0003108)2.91432006
41Myocardial infarction (HP:0001658)2.90767204
42Progressive macrocephaly (HP:0004481)2.88345722
43Hypothermia (HP:0002045)2.79502777
44Intestinal atresia (HP:0011100)2.76939742
45Conjugated hyperbilirubinemia (HP:0002908)2.76890055
46Spastic diplegia (HP:0001264)2.76813406
47Hypercholesterolemia (HP:0003124)2.75339192
48Hyperglycinemia (HP:0002154)2.75326112
49Hypomagnesemia (HP:0002917)2.70885108
50Abnormality of serine family amino acid metabolism (HP:0010894)2.70737827
51Abnormality of glycine metabolism (HP:0010895)2.70737827
52Acanthocytosis (HP:0001927)2.70093962
53Vascular calcification (HP:0004934)2.69557206
54Recurrent gram-negative bacterial infections (HP:0005420)2.62500283
55Pancreatic fibrosis (HP:0100732)2.62386393
56Abnormality of purine metabolism (HP:0004352)2.58680657
57Neoplasm of the adrenal gland (HP:0100631)2.58613623
58Pancreatic cysts (HP:0001737)2.57798043
59Methylmalonic acidemia (HP:0002912)2.57684716
60Thrombophlebitis (HP:0004418)2.55252924
61Hyperbilirubinemia (HP:0002904)2.55181579
62Prominent metopic ridge (HP:0005487)2.53184363
63Abnormality of serum amino acid levels (HP:0003112)2.47726677
64Conjunctival hamartoma (HP:0100780)2.47509613
65Acute necrotizing encephalopathy (HP:0006965)2.47122647
66Abnormal pancreas size (HP:0012094)2.46340996
67Medial flaring of the eyebrow (HP:0010747)2.43508923
68Esophageal varix (HP:0002040)2.42877627
69Abnormality of the metopic suture (HP:0005556)2.40456709
70Gingival bleeding (HP:0000225)2.40205237
71Large for gestational age (HP:0001520)2.40188415
72Abnormal tarsal ossification (HP:0008369)2.38733203
73Gaze-evoked nystagmus (HP:0000640)2.38468247
74Enlarged penis (HP:0000040)2.35702504
75Cardiovascular calcification (HP:0011915)2.33329057
76Colon cancer (HP:0003003)2.29631043
77Hamartoma of the eye (HP:0010568)2.29359463
78Aqueductal stenosis (HP:0002410)2.28814836
79True hermaphroditism (HP:0010459)2.28509807
80Ketoacidosis (HP:0001993)2.27640533
81Upper motor neuron abnormality (HP:0002127)2.27108627
82Acute encephalopathy (HP:0006846)2.23686724
83Nephronophthisis (HP:0000090)2.22808385
84Hyperuricemia (HP:0002149)2.21754024
85Increased purine levels (HP:0004368)2.21754024
86Volvulus (HP:0002580)2.20589937
87Hepatic necrosis (HP:0002605)2.19745856
88EEG with generalized epileptiform discharges (HP:0011198)2.18841303
89Abnormality of vitamin B metabolism (HP:0004340)2.18383838
90Abnormality of the renal cortex (HP:0011035)2.18014730
91Epileptiform EEG discharges (HP:0011182)2.17913787
92Abnormality of dicarboxylic acid metabolism (HP:0010995)2.17608680
93Dicarboxylic aciduria (HP:0003215)2.17608680
94Hyperventilation (HP:0002883)2.14486162
95Thrombocytosis (HP:0001894)2.13581234
96Hypsarrhythmia (HP:0002521)2.12008822
97Cupped ribs (HP:0000887)2.11927510
98Metabolic acidosis (HP:0001942)2.11051252
99Increased CSF lactate (HP:0002490)2.10934541
100Mitochondrial inheritance (HP:0001427)2.10474147
101Abnormality of fatty-acid metabolism (HP:0004359)2.10472012
102Steatorrhea (HP:0002570)2.09754394
103Gout (HP:0001997)2.09580438
104Delayed CNS myelination (HP:0002188)2.08321603
105Abnormal hair whorl (HP:0010721)2.06897768
106Abnormality of midbrain morphology (HP:0002418)2.05415563
107Molar tooth sign on MRI (HP:0002419)2.05415563
108Broad-based gait (HP:0002136)2.04734268
109Furrowed tongue (HP:0000221)2.03100400
110Insulin-resistant diabetes mellitus (HP:0000831)2.02923159
111Skin nodule (HP:0200036)2.02258042
112Protuberant abdomen (HP:0001538)1.99849413
113Systemic lupus erythematosus (HP:0002725)1.98428447
114Abnormal cartilage morphology (HP:0002763)1.96977229
115Methylmalonic aciduria (HP:0012120)1.96602246
116Abnormal foot bone ossification (HP:0010675)1.95969731
117Thyroid carcinoma (HP:0002890)1.95813108
118Abnormal mitochondria in muscle tissue (HP:0008316)1.95591625
119Congenital primary aphakia (HP:0007707)1.95363557
120Nausea (HP:0002018)1.94603049
121Gait imbalance (HP:0002141)1.94072919
122Abnormality of iron homeostasis (HP:0011031)1.92791301
123Calf muscle hypertrophy (HP:0008981)1.91323668
124Genital tract atresia (HP:0001827)1.89643063
125Hemiparesis (HP:0001269)1.88450982
126Abnormality of magnesium homeostasis (HP:0004921)1.87824800
127Increased mean platelet volume (HP:0011877)1.86689938
128Absent frontal sinuses (HP:0002688)1.85752552
129Menorrhagia (HP:0000132)1.84488289
130Thyroiditis (HP:0100646)1.84190585
131Global brain atrophy (HP:0002283)1.82947861
132Hepatocellular necrosis (HP:0001404)1.81882284
133Abnormality of the renal medulla (HP:0100957)1.81726765
134Optic nerve hypoplasia (HP:0000609)1.81392645
135Flat acetabular roof (HP:0003180)1.81252377
136Poikilocytosis (HP:0004447)1.81137583
137Aplasia/hypoplasia of the uterus (HP:0008684)1.80701338
138Meningioma (HP:0002858)1.80405155
139Ependymoma (HP:0002888)1.79946970
140Vaginal atresia (HP:0000148)1.79861207
141Exercise-induced muscle cramps (HP:0003710)1.78733905
142Abnormal platelet volume (HP:0011876)1.78694642
143Arthropathy (HP:0003040)1.78552193
144Increased hepatocellular lipid droplets (HP:0006565)1.78081529
145Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.77559003
146Abnormality of the vasculature of the conjunctiva (HP:0008054)1.76864814
147Cortical dysplasia (HP:0002539)1.76331830
148Proximal tubulopathy (HP:0000114)1.75425545
149Muscular hypotonia of the trunk (HP:0008936)1.74761674
150Neonatal onset (HP:0003623)1.74302912
151Back pain (HP:0003418)1.74080426
152Gastrointestinal atresia (HP:0002589)1.72997420
153Abnormality of transition element cation homeostasis (HP:0011030)1.72461202
154Myoglobinuria (HP:0002913)1.72260774
155Abnormality of lateral ventricle (HP:0030047)1.71656461
156Arterial thrombosis (HP:0004420)1.71607268
157Hepatoblastoma (HP:0002884)1.70461411
158Polydipsia (HP:0001959)1.70428873
159Abnormal drinking behavior (HP:0030082)1.70428873
160Hypoplasia of the fovea (HP:0007750)1.69390590
161Aplasia/Hypoplasia of the fovea (HP:0008060)1.69390590
162Late onset (HP:0003584)1.69080146
163Breast carcinoma (HP:0003002)1.69070987
164Nephrogenic diabetes insipidus (HP:0009806)1.68932858
165Lethargy (HP:0001254)1.68477738
166Angiofibromas (HP:0010615)1.68266193
167Adenoma sebaceum (HP:0009720)1.68266193
168Cerebral edema (HP:0002181)1.67505782
169Progressive inability to walk (HP:0002505)1.67488616
170Glycosuria (HP:0003076)1.66743123
171Abnormality of urine glucose concentration (HP:0011016)1.66743123
172Muscle hypertrophy of the lower extremities (HP:0008968)1.66604169
173Increased circulating renin level (HP:0000848)1.66336790
174Glioma (HP:0009733)1.65982604
175Astrocytoma (HP:0009592)1.65873346
176Abnormality of the astrocytes (HP:0100707)1.65873346
177Agnosia (HP:0010524)1.65250422
178Abolished electroretinogram (ERG) (HP:0000550)1.65219920
179Downturned corners of mouth (HP:0002714)1.65154338
180Vitreoretinal degeneration (HP:0000655)1.63545256
181Rhabdomyosarcoma (HP:0002859)1.62912970
182Abnormality of chromosome stability (HP:0003220)1.62894579
183Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.62582616
184Respiratory failure (HP:0002878)1.62486575
185Enlarged kidneys (HP:0000105)1.60888805
186Abnormal sex determination (HP:0012244)1.60775935
187Abnormal platelet function (HP:0011869)1.58962990
188Impaired platelet aggregation (HP:0003540)1.58962990
189Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.58247239
190Renal cortical cysts (HP:0000803)1.58212178
191Neoplasm of the liver (HP:0002896)1.57045569
192Rhabdomyolysis (HP:0003201)1.56133835

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.44228209
2BMPR1B3.33178544
3MST43.20120386
4FGFR23.03780912
5PKN23.01867289
6SCYL22.70978449
7CASK2.55597715
8NEK12.44876080
9FRK2.33139114
10NEK92.28830969
11BCKDK2.28528956
12TNIK2.27674216
13TRIM282.27259670
14PASK2.08460413
15WEE12.07630446
16MKNK21.99707758
17FLT31.98637826
18WNK31.98192102
19CDK61.96640065
20EIF2AK31.78124352
21ACVR1B1.76341554
22LATS11.75263609
23MAP4K21.74327332
24BUB11.73979147
25SIK11.73978856
26NEK21.72916234
27PNCK1.72013819
28ZAK1.66064557
29MST1R1.65920395
30PDK31.60239088
31PDK41.60239088
32MKNK11.59683283
33MAP2K31.58037070
34NLK1.51891188
35ERBB41.51074017
36MAP3K41.49267092
37EIF2AK11.47980800
38EEF2K1.47673443
39NME21.45098396
40CDK121.44417786
41MAPK111.44390686
42TSSK61.43104717
43STK391.36223549
44GRK11.35555521
45TRIB31.34575160
46TAF11.34265588
47CDK41.32661982
48RPS6KA41.30899185
49PIK3CA1.29741215
50PHKG21.29588002
51PHKG11.29588002
52TTK1.28659871
53ERBB31.28602626
54PIM11.27949361
55MAP3K81.24041196
56STK31.21891048
57ATR1.19911798
58PLK21.14627480
59PLK31.13775158
60AURKB1.11135083
61MAP3K31.10701295
62NTRK31.09849282
63NUAK11.09832200
64OXSR11.08107413
65CSNK1G11.07531778
66PLK11.05706405
67ADRBK21.04490799
68STK101.03332382
69MAP3K141.01494469
70SGK31.00769860
71MAP3K51.00713581
72TAOK31.00400852
73RIPK10.98258016
74TEC0.98195508
75INSRR0.97750310
76CSF1R0.97211769
77STK160.96231310
78MAP3K90.96094074
79TYK20.95581828
80DAPK20.92822419
81WNK40.91022922
82MAP3K20.90774324
83TLK10.89189918
84ALK0.88790833
85TTN0.88685033
86PRKCG0.88217267
87PTK60.86633603
88MAP3K100.86317936
89STK38L0.84865812
90RPS6KB10.84779696
91STK40.80560692
92PDK20.80331274
93SGK20.80301406
94RPS6KB20.79582440
95CAMK1D0.78268247
96CDK70.77376461
97VRK10.75938407
98PRKCE0.75593273
99VRK20.74975535
100ABL20.74860184
101ATM0.74322190
102MAP2K40.73442231
103CHEK10.72630156
104MATK0.72167207
105PDK10.71905943
106CHEK20.71560766
107CSK0.70087959
108BMX0.69641715
109STK240.68860499
110BRD40.67531871
111CCNB10.67391919
112CSNK1G20.66325479
113ERN10.66244696
114AKT20.66116586
115MAPK130.65881958
116PAK30.65437430
117PBK0.65302084
118GRK60.63874784
119OBSCN0.62192561
120TAOK20.61393139
121MAP3K70.60936241
122MAP4K10.60088179
123CSNK1G30.58412465
124TGFBR10.58120961
125CDK20.56741130
126JAK20.55775161
127CAMK1G0.55698757
128AKT30.55006899
129SRPK10.54916861
130DYRK1B0.51899302
131FGFR30.51392534
132CSNK2A20.51026703
133MAP3K60.50833724
134FER0.49723703
135BCR0.49538787
136CDK30.49432628
137EIF2AK20.49429893
138MAP2K70.48079834
139TBK10.47921257
140PLK40.47521564
141DYRK20.47360427
142LRRK20.47317453
143KIT0.46201273
144BRSK20.46080126
145PRKCI0.45573501
146PINK10.45058384
147PRKAA20.44662492
148IRAK10.43184312
149LYN0.41663025
150FGFR10.41483240
151CAMK2D0.41231394
152CSNK2A10.40931299
153MARK30.40646828
154MTOR0.40062324
155STK110.39626897
156TRPM70.39230943
157CSNK1A1L0.38589277
158CSNK1E0.37209946
159YES10.34697827
160DAPK10.32620670
161PRKDC0.32618322
162SGK2230.31028000
163SGK4940.31028000
164CSNK1D0.30757390
165CAMK2A0.29474155
166PRKACB0.27288943
167HIPK20.26971562

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.96664414
2Nitrogen metabolism_Homo sapiens_hsa009104.58246877
3Primary bile acid biosynthesis_Homo sapiens_hsa001203.66160169
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.52483143
5Protein export_Homo sapiens_hsa030603.24659020
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.18527211
7Arginine biosynthesis_Homo sapiens_hsa002202.97785767
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.57246850
9Pentose and glucuronate interconversions_Homo sapiens_hsa000402.56567580
10Fatty acid degradation_Homo sapiens_hsa000712.35606672
11One carbon pool by folate_Homo sapiens_hsa006702.34983051
12Complement and coagulation cascades_Homo sapiens_hsa046102.33287170
13Tryptophan metabolism_Homo sapiens_hsa003802.16038445
14Selenocompound metabolism_Homo sapiens_hsa004502.15547405
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.11145745
16Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.97057373
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.95630789
18Insulin secretion_Homo sapiens_hsa049111.89373043
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.84431454
20RNA polymerase_Homo sapiens_hsa030201.84056662
21Butanoate metabolism_Homo sapiens_hsa006501.83538560
22Basal transcription factors_Homo sapiens_hsa030221.80931737
23Drug metabolism - other enzymes_Homo sapiens_hsa009831.79129792
24Oxidative phosphorylation_Homo sapiens_hsa001901.78492256
25Proteasome_Homo sapiens_hsa030501.77661735
26Peroxisome_Homo sapiens_hsa041461.76076860
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.68526778
28Propanoate metabolism_Homo sapiens_hsa006401.68379951
29PPAR signaling pathway_Homo sapiens_hsa033201.61116253
30Sulfur metabolism_Homo sapiens_hsa009201.59859897
31Caffeine metabolism_Homo sapiens_hsa002321.58403346
32Chemical carcinogenesis_Homo sapiens_hsa052041.57263975
33Biosynthesis of amino acids_Homo sapiens_hsa012301.57112877
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.54998685
35Phototransduction_Homo sapiens_hsa047441.53194522
36Staphylococcus aureus infection_Homo sapiens_hsa051501.52460155
37Fatty acid metabolism_Homo sapiens_hsa012121.49660349
38Steroid hormone biosynthesis_Homo sapiens_hsa001401.49441740
39Carbon metabolism_Homo sapiens_hsa012001.48818480
40Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.47587091
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.46750818
42Starch and sucrose metabolism_Homo sapiens_hsa005001.46134541
43Fanconi anemia pathway_Homo sapiens_hsa034601.44165700
44Retinol metabolism_Homo sapiens_hsa008301.44156508
45Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.43455285
46Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.41562277
47Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.41169688
48Bile secretion_Homo sapiens_hsa049761.39855157
49DNA replication_Homo sapiens_hsa030301.38657290
50Nicotine addiction_Homo sapiens_hsa050331.37289430
51Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.34826412
52beta-Alanine metabolism_Homo sapiens_hsa004101.29967821
53Pyruvate metabolism_Homo sapiens_hsa006201.24808282
54Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.23265621
55Regulation of autophagy_Homo sapiens_hsa041401.21051406
56Parkinsons disease_Homo sapiens_hsa050121.14285681
57Lysine degradation_Homo sapiens_hsa003101.09157877
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.08769536
59Circadian rhythm_Homo sapiens_hsa047101.08025280
60Systemic lupus erythematosus_Homo sapiens_hsa053221.07816279
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.06269333
62Mismatch repair_Homo sapiens_hsa034301.05018346
63Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.02558306
64Histidine metabolism_Homo sapiens_hsa003401.00606489
65Purine metabolism_Homo sapiens_hsa002300.99116692
66Pentose phosphate pathway_Homo sapiens_hsa000300.98874253
67Phenylalanine metabolism_Homo sapiens_hsa003600.94415638
68Ether lipid metabolism_Homo sapiens_hsa005650.91583804
69Taste transduction_Homo sapiens_hsa047420.91315709
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.91079948
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.90349344
72Oocyte meiosis_Homo sapiens_hsa041140.89198695
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.88604354
74Collecting duct acid secretion_Homo sapiens_hsa049660.88546741
75Type II diabetes mellitus_Homo sapiens_hsa049300.86249301
76Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.85500366
77Cyanoamino acid metabolism_Homo sapiens_hsa004600.83752944
78Alzheimers disease_Homo sapiens_hsa050100.83389471
79Huntingtons disease_Homo sapiens_hsa050160.82500294
80Fat digestion and absorption_Homo sapiens_hsa049750.82440726
81Folate biosynthesis_Homo sapiens_hsa007900.81612905
82Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.81361586
83Sulfur relay system_Homo sapiens_hsa041220.80964407
84Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.80216853
85Tyrosine metabolism_Homo sapiens_hsa003500.78557447
86Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.78450548
87Circadian entrainment_Homo sapiens_hsa047130.72953346
88ABC transporters_Homo sapiens_hsa020100.72659941
89Arginine and proline metabolism_Homo sapiens_hsa003300.71494472
90Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.71212716
91Fructose and mannose metabolism_Homo sapiens_hsa000510.67795458
92Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.67694131
93Cardiac muscle contraction_Homo sapiens_hsa042600.67675632
94Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.67180958
95Renin secretion_Homo sapiens_hsa049240.66958107
96Amphetamine addiction_Homo sapiens_hsa050310.62812207
97Linoleic acid metabolism_Homo sapiens_hsa005910.61803388
98Glutamatergic synapse_Homo sapiens_hsa047240.60449505
99Vitamin digestion and absorption_Homo sapiens_hsa049770.59648279
100Hedgehog signaling pathway_Homo sapiens_hsa043400.58923395
101TGF-beta signaling pathway_Homo sapiens_hsa043500.58637972
102Serotonergic synapse_Homo sapiens_hsa047260.58173928
103Glycerolipid metabolism_Homo sapiens_hsa005610.56991330
104Long-term depression_Homo sapiens_hsa047300.55786272
105Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.54441989
106Glutathione metabolism_Homo sapiens_hsa004800.54107922
107Dorso-ventral axis formation_Homo sapiens_hsa043200.52192670
108Dopaminergic synapse_Homo sapiens_hsa047280.51241604
109GABAergic synapse_Homo sapiens_hsa047270.50284240
110Galactose metabolism_Homo sapiens_hsa000520.49874566
111Fatty acid biosynthesis_Homo sapiens_hsa000610.48422565
112mRNA surveillance pathway_Homo sapiens_hsa030150.48193011
113Synaptic vesicle cycle_Homo sapiens_hsa047210.46233573
114RNA transport_Homo sapiens_hsa030130.45732619
115Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.44136884
116Salivary secretion_Homo sapiens_hsa049700.40230535
117Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.39540536
118Nucleotide excision repair_Homo sapiens_hsa034200.37705999
119Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37418047
120Hippo signaling pathway_Homo sapiens_hsa043900.36721169
121Base excision repair_Homo sapiens_hsa034100.35745232
122Glucagon signaling pathway_Homo sapiens_hsa049220.35682750
123Metabolic pathways_Homo sapiens_hsa011000.35174172
124Cell cycle_Homo sapiens_hsa041100.32974176
125Pyrimidine metabolism_Homo sapiens_hsa002400.32533393
126Vitamin B6 metabolism_Homo sapiens_hsa007500.31606567
127Insulin resistance_Homo sapiens_hsa049310.25577560
128Legionellosis_Homo sapiens_hsa051340.25352991
129Steroid biosynthesis_Homo sapiens_hsa001000.24655993
130Homologous recombination_Homo sapiens_hsa034400.22792260
131RNA degradation_Homo sapiens_hsa030180.22755676
132Non-homologous end-joining_Homo sapiens_hsa034500.19523617
133Renin-angiotensin system_Homo sapiens_hsa046140.17459050
134Herpes simplex infection_Homo sapiens_hsa051680.17185715
135Adipocytokine signaling pathway_Homo sapiens_hsa049200.13472689
136RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.13066088
137Central carbon metabolism in cancer_Homo sapiens_hsa052300.12310068
138Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.10662202
139Antigen processing and presentation_Homo sapiens_hsa046120.10077012
140Viral carcinogenesis_Homo sapiens_hsa052030.09968707
141Fatty acid elongation_Homo sapiens_hsa000620.07770525
142Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.04002924
143alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.01627354
144Thyroid cancer_Homo sapiens_hsa052160.01085336
145p53 signaling pathway_Homo sapiens_hsa04115-0.0143773
146NF-kappa B signaling pathway_Homo sapiens_hsa04064-0.0101704
147Spliceosome_Homo sapiens_hsa03040-0.0044423
148Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0044312
149Viral myocarditis_Homo sapiens_hsa05416-0.0037402

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