MPLKIP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene localizes to the centrosome during mitosis and to the midbody during cytokinesis. The protein is phosphorylated by cyclin-dependent kinase 1 during mitosis and subsequently interacts with polo-like kinase 1. The protein is thought to function in regulating mitosis and cytokinesis. Mutations in this gene result in nonphotosensitive trichothiodystrophy. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)7.46863825
2central nervous system myelination (GO:0022010)7.46863825
3behavioral response to nicotine (GO:0035095)5.36883270
4fatty acid elongation (GO:0030497)5.32844502
5ribosomal small subunit biogenesis (GO:0042274)5.28914291
6viral transcription (GO:0019083)5.15031145
7translational termination (GO:0006415)4.93651802
8ribosomal small subunit assembly (GO:0000028)4.51563606
9cotranslational protein targeting to membrane (GO:0006613)4.50955116
10mitochondrial respiratory chain complex assembly (GO:0033108)4.41561964
11protein targeting to ER (GO:0045047)4.41533294
12SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.39778360
13establishment of protein localization to endoplasmic reticulum (GO:0072599)4.26043860
14protein localization to endoplasmic reticulum (GO:0070972)4.17992754
15lymphoid progenitor cell differentiation (GO:0002320)4.05220599
16long-chain fatty acid biosynthetic process (GO:0042759)3.90861793
17cytochrome complex assembly (GO:0017004)3.88138011
18GPI anchor biosynthetic process (GO:0006506)3.85585009
19presynaptic membrane assembly (GO:0097105)3.78035873
20translational elongation (GO:0006414)3.76733604
21cellular protein complex disassembly (GO:0043624)3.76218664
22water-soluble vitamin biosynthetic process (GO:0042364)3.75709477
23histone H2B ubiquitination (GO:0033523)3.75470926
24viral life cycle (GO:0019058)3.73439630
25establishment of integrated proviral latency (GO:0075713)3.71158899
26presynaptic membrane organization (GO:0097090)3.65089578
27limb bud formation (GO:0060174)3.63465047
28response to pheromone (GO:0019236)3.62831292
29GTP biosynthetic process (GO:0006183)3.59623651
30preassembly of GPI anchor in ER membrane (GO:0016254)3.58188711
31GPI anchor metabolic process (GO:0006505)3.56077095
32protein-cofactor linkage (GO:0018065)3.55467151
33tryptophan catabolic process (GO:0006569)3.55363562
34indole-containing compound catabolic process (GO:0042436)3.55363562
35indolalkylamine catabolic process (GO:0046218)3.55363562
36kynurenine metabolic process (GO:0070189)3.53937699
37myelination (GO:0042552)3.51092173
38axon ensheathment (GO:0008366)3.50731436
39ensheathment of neurons (GO:0007272)3.50731436
40positive regulation of cellular amine metabolic process (GO:0033240)3.48951271
41nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.46365751
42indolalkylamine metabolic process (GO:0006586)3.45330616
43DNA ligation (GO:0006266)3.44837040
44DNA deamination (GO:0045006)3.40958324
45negative regulation of execution phase of apoptosis (GO:1900118)3.38612505
46mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.37948975
47cellular ketone body metabolic process (GO:0046950)3.34447865
48ribosomal large subunit biogenesis (GO:0042273)3.32836882
49negative regulation of transcription by competitive promoter binding (GO:0010944)3.30312329
50maturation of SSU-rRNA (GO:0030490)3.28468449
51energy coupled proton transport, down electrochemical gradient (GO:0015985)3.28157804
52ATP synthesis coupled proton transport (GO:0015986)3.28157804
53mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.27726420
54tryptophan metabolic process (GO:0006568)3.24757002
55oligodendrocyte differentiation (GO:0048709)3.23132302
56establishment of viral latency (GO:0019043)3.22996735
57negative regulation of telomere maintenance (GO:0032205)3.17771965
58protein complex disassembly (GO:0043241)3.14411390
59ubiquinone biosynthetic process (GO:0006744)3.12767924
60platelet dense granule organization (GO:0060155)3.10632662
61tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.06292253
62RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.06292253
63detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.02535321
64translational initiation (GO:0006413)3.02165794
65UTP biosynthetic process (GO:0006228)3.01372011
66ketone body metabolic process (GO:1902224)3.01356913
67deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.99886263
68proteasome assembly (GO:0043248)2.99795481
69mannosylation (GO:0097502)2.98391023
70nonmotile primary cilium assembly (GO:0035058)2.93541260
71macromolecular complex disassembly (GO:0032984)2.92614941
72C-terminal protein lipidation (GO:0006501)2.90520984
73ubiquinone metabolic process (GO:0006743)2.90220216
74chaperone-mediated protein transport (GO:0072321)2.90107395
75regulation of nuclear cell cycle DNA replication (GO:0033262)2.89141924
76negative regulation of neurotransmitter transport (GO:0051589)2.85634767
77sulfation (GO:0051923)2.84921944
78L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.84568579
79gamma-aminobutyric acid transport (GO:0015812)2.84007772
80negative regulation of transcription regulatory region DNA binding (GO:2000678)2.83545383
81detection of light stimulus involved in visual perception (GO:0050908)2.82772797
82detection of light stimulus involved in sensory perception (GO:0050962)2.82772797
83respiratory chain complex IV assembly (GO:0008535)2.82591646
84fucose catabolic process (GO:0019317)2.82556646
85L-fucose metabolic process (GO:0042354)2.82556646
86L-fucose catabolic process (GO:0042355)2.82556646
87mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.82301338
88mitochondrial respiratory chain complex I assembly (GO:0032981)2.82301338
89NADH dehydrogenase complex assembly (GO:0010257)2.82301338
90keratinocyte development (GO:0003334)2.81528662
91protein targeting to membrane (GO:0006612)2.81415379
92developmental pigmentation (GO:0048066)2.80961280
93regulation of pigment cell differentiation (GO:0050932)2.80683505
94tRNA processing (GO:0008033)2.79957641
95recombinational repair (GO:0000725)2.77832249
96neuron cell-cell adhesion (GO:0007158)2.76654837
97positive regulation of oligodendrocyte differentiation (GO:0048714)2.76203535
98protein palmitoylation (GO:0018345)2.76057696
99protein neddylation (GO:0045116)2.75591725
100double-strand break repair via homologous recombination (GO:0000724)2.74702442
101piRNA metabolic process (GO:0034587)2.74405243
102intracellular protein transmembrane import (GO:0044743)2.74088277
103RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.73619334
104cranial nerve morphogenesis (GO:0021602)2.73525354
105eye photoreceptor cell differentiation (GO:0001754)2.72394215
106photoreceptor cell differentiation (GO:0046530)2.72394215
107positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.71655766
108glycerophospholipid catabolic process (GO:0046475)2.70831293
109replication fork processing (GO:0031297)2.69877798
110peptidyl-histidine modification (GO:0018202)2.69588873
111regulation of mitochondrial translation (GO:0070129)2.69296310
112translation (GO:0006412)2.67403877
113organ growth (GO:0035265)2.66798428
114protein polyglutamylation (GO:0018095)2.66760018
115reciprocal meiotic recombination (GO:0007131)2.66239850
116reciprocal DNA recombination (GO:0035825)2.66239850
117epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.64485608
118CTP biosynthetic process (GO:0006241)2.63864999
119CTP metabolic process (GO:0046036)2.63864999
120regulation of collateral sprouting (GO:0048670)2.62967961
121indole-containing compound metabolic process (GO:0042430)2.62816906
122cerebral cortex radially oriented cell migration (GO:0021799)2.60494040
123oxidative demethylation (GO:0070989)2.57814519
124protein complex biogenesis (GO:0070271)2.55235825
125L-methionine biosynthetic process (GO:0071265)2.54443617
126amino acid salvage (GO:0043102)2.54443617
127L-methionine salvage (GO:0071267)2.54443617
128axoneme assembly (GO:0035082)2.54442964
129pseudouridine synthesis (GO:0001522)2.53982684
130maturation of 5.8S rRNA (GO:0000460)2.52988568
131metallo-sulfur cluster assembly (GO:0031163)2.52435630
132iron-sulfur cluster assembly (GO:0016226)2.52435630
133respiratory electron transport chain (GO:0022904)2.51567252
134S-adenosylmethionine metabolic process (GO:0046500)2.51362500
135nuclear-transcribed mRNA catabolic process (GO:0000956)2.50808923
136quinone biosynthetic process (GO:1901663)2.50296843
137fucosylation (GO:0036065)2.49936222
138axonemal dynein complex assembly (GO:0070286)2.49650748
139negative regulation of neurotransmitter secretion (GO:0046929)2.49507592
140UTP metabolic process (GO:0046051)2.49315274
141signal peptide processing (GO:0006465)2.49184378
142magnesium ion transport (GO:0015693)2.49044949
143hydrogen ion transmembrane transport (GO:1902600)2.48807421
144tRNA modification (GO:0006400)2.47910613
145electron transport chain (GO:0022900)2.47890853
146regulation of cilium movement (GO:0003352)2.46999312
147mitochondrial RNA metabolic process (GO:0000959)2.46071848
148anterograde synaptic vesicle transport (GO:0048490)2.45967174
149exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.45903498
150DNA double-strand break processing (GO:0000729)2.44944522
151establishment of protein localization to mitochondrial membrane (GO:0090151)2.44821536
152transcription elongation from RNA polymerase III promoter (GO:0006385)2.44425938
153termination of RNA polymerase III transcription (GO:0006386)2.44425938
154isoprenoid biosynthetic process (GO:0008299)2.43968741
155response to redox state (GO:0051775)2.43062856
156glycolipid biosynthetic process (GO:0009247)2.42705678
157proton transport (GO:0015992)2.42451733
158ATP biosynthetic process (GO:0006754)2.41460723
159nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.41322433
160negative regulation of T cell differentiation in thymus (GO:0033085)2.41317885
161rRNA catabolic process (GO:0016075)2.41235950
162mRNA catabolic process (GO:0006402)2.39778239
163DNA damage response, detection of DNA damage (GO:0042769)2.39326643
164negative regulation of DNA-dependent DNA replication (GO:2000104)2.37240003
165regulation of mitotic spindle checkpoint (GO:1903504)2.36891501
166regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.36891501
167C-terminal protein amino acid modification (GO:0018410)2.36367059
168negative regulation of mast cell activation (GO:0033004)2.35882718
169hydrogen transport (GO:0006818)2.35851227
170cornea development in camera-type eye (GO:0061303)2.35823444
171epithelial cilium movement (GO:0003351)2.35228927
172regulation of action potential (GO:0098900)2.35043910
173regulation of hexokinase activity (GO:1903299)2.34937093
174dopamine biosynthetic process (GO:0042416)2.33488210

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat6.24997212
2ZNF274_21170338_ChIP-Seq_K562_Hela4.09686490
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.68555533
4EZH2_22144423_ChIP-Seq_EOC_Human3.33177595
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.20975186
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.73339821
7TAF15_26573619_Chip-Seq_HEK293_Human2.69302791
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.51252093
9GBX2_23144817_ChIP-Seq_PC3_Human2.47903119
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.34729661
11IRF1_19129219_ChIP-ChIP_H3396_Human2.31212297
12BMI1_23680149_ChIP-Seq_NPCS_Mouse2.24547577
13VDR_22108803_ChIP-Seq_LS180_Human2.22053440
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.21155049
15PCGF2_27294783_Chip-Seq_ESCs_Mouse2.14931745
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.12198857
17FUS_26573619_Chip-Seq_HEK293_Human2.09116610
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.06552110
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.05264876
20GABP_17652178_ChIP-ChIP_JURKAT_Human1.99868607
21CBX2_27304074_Chip-Seq_ESCs_Mouse1.97664260
22EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.97044099
23FLI1_27457419_Chip-Seq_LIVER_Mouse1.96977515
24IGF1R_20145208_ChIP-Seq_DFB_Human1.94789061
25POU3F2_20337985_ChIP-ChIP_501MEL_Human1.90003078
26TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83513463
27PCGF2_27294783_Chip-Seq_NPCs_Mouse1.77665244
28JARID2_20064375_ChIP-Seq_MESCs_Mouse1.75231706
29FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.71898808
30EST1_17652178_ChIP-ChIP_JURKAT_Human1.71457010
31TP53_22573176_ChIP-Seq_HFKS_Human1.68494691
32POU5F1_16153702_ChIP-ChIP_HESCs_Human1.68419229
33EWS_26573619_Chip-Seq_HEK293_Human1.67847897
34EZH2_27304074_Chip-Seq_ESCs_Mouse1.66203971
35MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.63551402
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.62009430
37HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.61955973
38NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.58024870
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.57443915
40CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.57016576
41SUZ12_27294783_Chip-Seq_NPCs_Mouse1.55267805
42RNF2_27304074_Chip-Seq_NSC_Mouse1.53142912
43SALL1_21062744_ChIP-ChIP_HESCs_Human1.49056187
44ER_23166858_ChIP-Seq_MCF-7_Human1.48723163
45BP1_19119308_ChIP-ChIP_Hs578T_Human1.47515330
46FOXA1_25329375_ChIP-Seq_VCAP_Human1.47213745
47FOXA1_27270436_Chip-Seq_PROSTATE_Human1.47213745
48EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.46747157
49NFE2_27457419_Chip-Seq_LIVER_Mouse1.46469193
50FOXP3_21729870_ChIP-Seq_TREG_Human1.44672673
51P300_19829295_ChIP-Seq_ESCs_Human1.44110170
52EZH2_27294783_Chip-Seq_NPCs_Mouse1.43192387
53NANOG_18555785_Chip-Seq_ESCs_Mouse1.41733877
54EED_16625203_ChIP-ChIP_MESCs_Mouse1.40284822
55PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.40189995
56SUZ12_18555785_Chip-Seq_ESCs_Mouse1.39931239
57SCL_19346495_ChIP-Seq_HPC-7_Human1.39650023
58TAL1_26923725_Chip-Seq_HPCs_Mouse1.38559425
59RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.37905076
60EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.34508514
61P300_18555785_Chip-Seq_ESCs_Mouse1.33681595
62CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.33617447
63JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.30405352
64CTBP2_25329375_ChIP-Seq_LNCAP_Human1.30156079
65NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.28565400
66CMYC_18555785_Chip-Seq_ESCs_Mouse1.28503805
67P53_22387025_ChIP-Seq_ESCs_Mouse1.28226805
68STAT3_18555785_Chip-Seq_ESCs_Mouse1.28159694
69AR_20517297_ChIP-Seq_VCAP_Human1.27965668
70NANOG_19829295_ChIP-Seq_ESCs_Human1.27846932
71SOX2_19829295_ChIP-Seq_ESCs_Human1.27846932
72TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.27667059
73OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26219547
74RUNX1_27457419_Chip-Seq_LIVER_Mouse1.24815692
75GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.24690217
76SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.23773351
77NOTCH1_21737748_ChIP-Seq_TLL_Human1.23355976
78GATA3_21878914_ChIP-Seq_MCF-7_Human1.22466268
79SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.22441303
80LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.21267961
81EGR1_23403033_ChIP-Seq_LIVER_Mouse1.20996111
82UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19790900
83ETS1_20019798_ChIP-Seq_JURKAT_Human1.19629711
84E2F1_18555785_Chip-Seq_ESCs_Mouse1.18980048
85SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17893445
86STAT6_21828071_ChIP-Seq_BEAS2B_Human1.17715214
87ELK1_19687146_ChIP-ChIP_HELA_Human1.17164891
88NMYC_18555785_Chip-Seq_ESCs_Mouse1.17106008
89NCOR_22424771_ChIP-Seq_293T_Human1.16904900
90ETV2_25802403_ChIP-Seq_MESCs_Mouse1.16146890
91IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.15438999
92CBP_20019798_ChIP-Seq_JUKART_Human1.15438999
93OCT4_18555785_Chip-Seq_ESCs_Mouse1.14461566
94BCAT_22108803_ChIP-Seq_LS180_Human1.14338859
95MYC_18940864_ChIP-ChIP_HL60_Human1.14201996
96KLF4_18555785_Chip-Seq_ESCs_Mouse1.13490654
97VDR_23849224_ChIP-Seq_CD4+_Human1.13049789
98CREB1_15753290_ChIP-ChIP_HEK293T_Human1.12933032
99CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.12743904
100RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12657564
101FOXA1_21572438_ChIP-Seq_LNCaP_Human1.12187871
102SMAD3_21741376_ChIP-Seq_EPCs_Human1.11467185
103SMAD1_18555785_Chip-Seq_ESCs_Mouse1.10421739
104MYC_18555785_ChIP-Seq_MESCs_Mouse1.08987235
105ZFX_18555785_Chip-Seq_ESCs_Mouse1.08946835
106TP63_19390658_ChIP-ChIP_HaCaT_Human1.08281405
107* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.06929631
108RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.06700929
109TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06521769
110POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06521769
111GABP_19822575_ChIP-Seq_HepG2_Human1.05085751
112SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.04713496
113PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.04669847
114HOXB7_26014856_ChIP-Seq_BT474_Human1.04199941
115KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04023543
116SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.03517007
117SOX2_18555785_Chip-Seq_ESCs_Mouse1.03364753
118PIAS1_25552417_ChIP-Seq_VCAP_Human1.03355944
119CRX_20693478_ChIP-Seq_RETINA_Mouse1.03155824
120NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02799395
121ERA_21632823_ChIP-Seq_H3396_Human1.02730315
122PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02397095
123AUTS2_25519132_ChIP-Seq_293T-REX_Human1.02216346
124AR_25329375_ChIP-Seq_VCAP_Human1.02166933
125SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.00560356
126AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00170725
127TCF4_22108803_ChIP-Seq_LS180_Human0.99256283
128CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.98845803
129NANOG_20526341_ChIP-Seq_ESCs_Human0.98349938
130TAF2_19829295_ChIP-Seq_ESCs_Human0.97877555
131CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97860266
132STAT3_23295773_ChIP-Seq_U87_Human0.97752471
133MYC_19829295_ChIP-Seq_ESCs_Human0.97650444
134WT1_19549856_ChIP-ChIP_CCG9911_Human0.96687678
135CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.96633620
136FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.96405772
137SRF_21415370_ChIP-Seq_HL-1_Mouse0.96036941
138EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.95990133
139SUZ12_27294783_Chip-Seq_ESCs_Mouse0.95573128
140PADI4_21655091_ChIP-ChIP_MCF-7_Human0.94659933
141REST_21632747_ChIP-Seq_MESCs_Mouse0.94456204
142PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.94319424
143TCF4_23295773_ChIP-Seq_U87_Human0.93808178
144LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93697801
145PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.93688684
146EZH2_27294783_Chip-Seq_ESCs_Mouse0.93136182
147P53_21459846_ChIP-Seq_SAOS-2_Human0.91922240
148CTCF_18555785_Chip-Seq_ESCs_Mouse0.91803018
149PU1_27457419_Chip-Seq_LIVER_Mouse0.91535211
150ERG_20887958_ChIP-Seq_HPC-7_Mouse0.90423565
151JARID2_20075857_ChIP-Seq_MESCs_Mouse0.90247264
152ESRRB_18555785_Chip-Seq_ESCs_Mouse0.89851990
153E2F4_17652178_ChIP-ChIP_JURKAT_Human0.89669629
154OCT4_21477851_ChIP-Seq_ESCs_Mouse0.89177559

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color4.02512204
2MP0009379_abnormal_foot_pigmentation3.64023211
3MP0003880_abnormal_central_pattern3.60422961
4MP0002102_abnormal_ear_morphology3.27467093
5MP0005409_darkened_coat_color3.21646745
6MP0003195_calcinosis3.09435521
7MP0004381_abnormal_hair_follicle2.98814289
8MP0001188_hyperpigmentation2.91219606
9MP0000920_abnormal_myelination2.62394031
10MP0005174_abnormal_tail_pigmentation2.40895428
11MP0006292_abnormal_olfactory_placode2.35126634
12MP0001529_abnormal_vocalization2.32710938
13MP0000569_abnormal_digit_pigmentation2.28153798
14MP0000566_synostosis2.19725795
15MP0003646_muscle_fatigue2.18790537
16MP0001905_abnormal_dopamine_level2.17611638
17MP0008875_abnormal_xenobiotic_pharmacok2.17028518
18MP0004742_abnormal_vestibular_system2.16831473
19MP0008057_abnormal_DNA_replication2.12686210
20MP0005075_abnormal_melanosome_morpholog2.07603524
21MP0005379_endocrine/exocrine_gland_phen1.94171056
22MP0002837_dystrophic_cardiac_calcinosis1.91145971
23MP0004142_abnormal_muscle_tone1.90097267
24MP0002653_abnormal_ependyma_morphology1.87222937
25MP0008872_abnormal_physiological_respon1.87120255
26MP0003938_abnormal_ear_development1.82550135
27MP0003718_maternal_effect1.81237626
28MP0002876_abnormal_thyroid_physiology1.80732956
29MP0002938_white_spotting1.77620689
30MP0001968_abnormal_touch/_nociception1.77268288
31MP0000015_abnormal_ear_pigmentation1.76993757
32MP0005646_abnormal_pituitary_gland1.76823348
33MP0001485_abnormal_pinna_reflex1.75985609
34MP0000383_abnormal_hair_follicle1.73847687
35MP0004043_abnormal_pH_regulation1.72950865
36MP0005645_abnormal_hypothalamus_physiol1.69514360
37MP0003724_increased_susceptibility_to1.65677927
38MP0002095_abnormal_skin_pigmentation1.64352368
39MP0005171_absent_coat_pigmentation1.62941415
40MP0001486_abnormal_startle_reflex1.60682998
41MP0004147_increased_porphyrin_level1.60665086
42MP0002736_abnormal_nociception_after1.52492702
43MP0005423_abnormal_somatic_nervous1.50820726
44MP0006072_abnormal_retinal_apoptosis1.49652375
45MP0001986_abnormal_taste_sensitivity1.49579805
46MP0005451_abnormal_body_composition1.49578833
47MP0005084_abnormal_gallbladder_morpholo1.47072914
48MP0002160_abnormal_reproductive_system1.43900750
49MP0002132_abnormal_respiratory_system1.41284705
50MP0002396_abnormal_hematopoietic_system1.40665164
51MP0003787_abnormal_imprinting1.38559036
52MP0005410_abnormal_fertilization1.37189321
53MP0000462_abnormal_digestive_system1.36936110
54MP0002272_abnormal_nervous_system1.34229936
55MP0005389_reproductive_system_phenotype1.33160158
56MP0003693_abnormal_embryo_hatching1.32020713
57MP0002234_abnormal_pharynx_morphology1.31573667
58MP0002277_abnormal_respiratory_mucosa1.29365669
59MP0000026_abnormal_inner_ear1.28150749
60MP0000427_abnormal_hair_cycle1.26984364
61MP0001963_abnormal_hearing_physiology1.25496996
62MP0005671_abnormal_response_to1.25175829
63MP0009697_abnormal_copulation1.23444036
64MP0003806_abnormal_nucleotide_metabolis1.22789272
65MP0004145_abnormal_muscle_electrophysio1.22475105
66MP0000631_abnormal_neuroendocrine_gland1.21467019
67MP0001764_abnormal_homeostasis1.21300615
68MP0008789_abnormal_olfactory_epithelium1.20115578
69MP0005551_abnormal_eye_electrophysiolog1.18036432
70MP0004885_abnormal_endolymph1.16820100
71MP0006276_abnormal_autonomic_nervous1.15362716
72MP0000465_gastrointestinal_hemorrhage1.13870140
73MP0002638_abnormal_pupillary_reflex1.12528527
74MP0005085_abnormal_gallbladder_physiolo1.12284498
75MP0001919_abnormal_reproductive_system1.11988476
76MP0000049_abnormal_middle_ear1.11257253
77MP0006036_abnormal_mitochondrial_physio1.09737715
78MP0008058_abnormal_DNA_repair1.09428060
79MP0002148_abnormal_hypersensitivity_rea1.08951322
80MP0000778_abnormal_nervous_system1.08237172
81MP0000372_irregular_coat_pigmentation1.08054543
82MP0008260_abnormal_autophagy1.06681020
83MP0002735_abnormal_chemical_nociception1.06639624
84MP0001293_anophthalmia1.05597811
85MP0000490_abnormal_crypts_of1.04356238
86MP0010678_abnormal_skin_adnexa1.04028906
87MP0003186_abnormal_redox_activity1.03305450
88MP0002557_abnormal_social/conspecific_i1.02130179
89MP0002752_abnormal_somatic_nervous1.01051279
90MP0010094_abnormal_chromosome_stability1.01031308
91MP0000613_abnormal_salivary_gland1.00706862
92MP0003315_abnormal_perineum_morphology0.99924295
93MP0001727_abnormal_embryo_implantation0.98684376
94MP0001501_abnormal_sleep_pattern0.98532566
95MP0003119_abnormal_digestive_system0.98053754
96MP0005332_abnormal_amino_acid0.97920672
97MP0010386_abnormal_urinary_bladder0.96445704
98MP0002928_abnormal_bile_duct0.96198700
99MP0009046_muscle_twitch0.94880982
100MP0002572_abnormal_emotion/affect_behav0.94617567
101MP0009745_abnormal_behavioral_response0.93151151
102MP0004924_abnormal_behavior0.92964073
103MP0005386_behavior/neurological_phenoty0.92964073
104MP0003121_genomic_imprinting0.92187512
105MP0001851_eye_inflammation0.92027345
106MP0003567_abnormal_fetal_cardiomyocyte0.91076218
107MP0004270_analgesia0.89600912
108MP0002177_abnormal_outer_ear0.89220261
109MP0002064_seizures0.88753195
110MP0002138_abnormal_hepatobiliary_system0.87971113
111MP0008877_abnormal_DNA_methylation0.87849093
112MP0002210_abnormal_sex_determination0.87847037
113MP0005187_abnormal_penis_morphology0.87426813
114MP0001929_abnormal_gametogenesis0.87265039
115MP0002229_neurodegeneration0.86268281
116MP0005000_abnormal_immune_tolerance0.86251474
117MP0001984_abnormal_olfaction0.86049489
118MP0000470_abnormal_stomach_morphology0.85602575
119MP0002163_abnormal_gland_morphology0.85393689
120MP0009333_abnormal_splenocyte_physiolog0.85016894
121MP0005360_urolithiasis0.84829853
122MP0001970_abnormal_pain_threshold0.84668031
123MP0003866_abnormal_defecation0.84502918
124MP0005253_abnormal_eye_physiology0.83336990
125MP0001346_abnormal_lacrimal_gland0.83127336
126MP0003937_abnormal_limbs/digits/tail_de0.82833412
127MP0002723_abnormal_immune_serum0.80419862
128MP0001440_abnormal_grooming_behavior0.80092519
129MP0003252_abnormal_bile_duct0.79846505
130MP0002067_abnormal_sensory_capabilities0.78658667
131MP0004133_heterotaxia0.77206897
132MP0008995_early_reproductive_senescence0.75797648
133MP0004134_abnormal_chest_morphology0.74781097
134MP0005025_abnormal_response_to0.74215806
135MP0005195_abnormal_posterior_eye0.73942619
136MP0001800_abnormal_humoral_immune0.72850978
137MP0001661_extended_life_span0.72581486
138MP0003011_delayed_dark_adaptation0.72527221
139MP0005387_immune_system_phenotype0.72200893
140MP0001790_abnormal_immune_system0.72200893
141MP0009250_abnormal_appendicular_skeleto0.71523712
142MP0009785_altered_susceptibility_to0.71444126
143MP0002420_abnormal_adaptive_immunity0.69191521
144MP0002751_abnormal_autonomic_nervous0.67699598
145MP0003786_premature_aging0.67576049
146MP0008932_abnormal_embryonic_tissue0.66663376
147MP0001819_abnormal_immune_cell0.65659957
148MP0001853_heart_inflammation0.65070714
149MP0002249_abnormal_larynx_morphology0.64699476
150MP0000647_abnormal_sebaceous_gland0.64309923
151MP0003698_abnormal_male_reproductive0.64262989

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)4.30051759
2Pancreatic cysts (HP:0001737)4.15960030
3Abnormal number of erythroid precursors (HP:0012131)4.03221596
4Reticulocytopenia (HP:0001896)3.99362259
5Abnormality of midbrain morphology (HP:0002418)3.96128250
6Molar tooth sign on MRI (HP:0002419)3.96128250
7Parakeratosis (HP:0001036)3.89366099
8Pancreatic fibrosis (HP:0100732)3.56057575
9Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.54001824
10Abnormality of alanine metabolism (HP:0010916)3.54001824
11Hyperalaninemia (HP:0003348)3.54001824
12Congenital stationary night blindness (HP:0007642)3.51315592
13True hermaphroditism (HP:0010459)3.40736419
14Nephronophthisis (HP:0000090)3.37517865
15Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.37367129
16Dynein arm defect of respiratory motile cilia (HP:0012255)3.32183733
17Absent/shortened dynein arms (HP:0200106)3.32183733
18Type II lissencephaly (HP:0007260)3.24757742
19Asplenia (HP:0001746)3.24285217
20Abnormal ciliary motility (HP:0012262)3.20917052
21Abnormal respiratory epithelium morphology (HP:0012253)3.15674850
22Abnormal respiratory motile cilium morphology (HP:0005938)3.15674850
23Renal Fanconi syndrome (HP:0001994)3.06283738
243-Methylglutaconic aciduria (HP:0003535)3.05681374
25Patchy hypopigmentation of hair (HP:0011365)3.03127887
26Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.01699804
27Increased hepatocellular lipid droplets (HP:0006565)3.00160840
28White forelock (HP:0002211)2.99857073
29Macrocytic anemia (HP:0001972)2.97186540
30Aplasia/Hypoplasia of the spleen (HP:0010451)2.96405539
31Abnormality of secondary sexual hair (HP:0009888)2.95687375
32Abnormality of the axillary hair (HP:0100134)2.95687375
33Pallor (HP:0000980)2.91224806
34Abnormal respiratory motile cilium physiology (HP:0012261)2.90948557
35Acute necrotizing encephalopathy (HP:0006965)2.84777923
36Abnormality of the renal medulla (HP:0100957)2.84070137
37Degeneration of the lateral corticospinal tracts (HP:0002314)2.80920704
38Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.80920704
39Medial flaring of the eyebrow (HP:0010747)2.76085809
40Abolished electroretinogram (ERG) (HP:0000550)2.74183839
41Abnormality of the renal cortex (HP:0011035)2.73684588
42Mitochondrial inheritance (HP:0001427)2.73633792
43Peripheral hypomyelination (HP:0007182)2.65695576
44Pendular nystagmus (HP:0012043)2.62766201
45Hepatic necrosis (HP:0002605)2.60652037
46Congenital, generalized hypertrichosis (HP:0004540)2.58032269
47Birth length less than 3rd percentile (HP:0003561)2.51749836
48Retinal dysplasia (HP:0007973)2.49570098
49Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.49206134
50Abnormality of the pons (HP:0007361)2.45660581
51Hypoplasia of the pons (HP:0012110)2.44524639
52Absent rod-and cone-mediated responses on ERG (HP:0007688)2.42879359
53Tubular atrophy (HP:0000092)2.40723905
54Hepatocellular necrosis (HP:0001404)2.40442363
55Increased serum lactate (HP:0002151)2.39251702
56Chronic hepatic failure (HP:0100626)2.38946954
57Hypothermia (HP:0002045)2.35822304
58Sclerocornea (HP:0000647)2.34051602
59Progressive macrocephaly (HP:0004481)2.33403421
60Septo-optic dysplasia (HP:0100842)2.32604094
61Cerebellar dysplasia (HP:0007033)2.31219996
62Lipid accumulation in hepatocytes (HP:0006561)2.30260327
63Decreased electroretinogram (ERG) amplitude (HP:0000654)2.28224803
64Methylmalonic acidemia (HP:0002912)2.26994255
65Methylmalonic aciduria (HP:0012120)2.25761626
66Duplicated collecting system (HP:0000081)2.25476456
67Cerebral edema (HP:0002181)2.25387306
68Abnormality of renal resorption (HP:0011038)2.24726237
69Abnormal mitochondria in muscle tissue (HP:0008316)2.23054220
70Partial duplication of thumb phalanx (HP:0009944)2.22813891
71Aplasia/Hypoplasia of the sacrum (HP:0008517)2.22735356
72Microvesicular hepatic steatosis (HP:0001414)2.22570343
73Cystic liver disease (HP:0006706)2.22148269
74Chromsome breakage (HP:0040012)2.21602436
75Abnormality of the heme biosynthetic pathway (HP:0010472)2.21286001
76Absent septum pellucidum (HP:0001331)2.21158044
77Patellar aplasia (HP:0006443)2.20865431
78Inability to walk (HP:0002540)2.20803959
79Chorioretinal atrophy (HP:0000533)2.18675131
80Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.17807172
81Hyperventilation (HP:0002883)2.17700098
82Hyperglycinemia (HP:0002154)2.16277296
83Cupped ear (HP:0000378)2.15998147
84Aplasia/Hypoplasia of the patella (HP:0006498)2.15948341
85Lactic acidosis (HP:0003128)2.14375595
86Renal cortical cysts (HP:0000803)2.14117166
87Lissencephaly (HP:0001339)2.13800780
88Duplication of thumb phalanx (HP:0009942)2.13332109
89Chromosomal breakage induced by crosslinking agents (HP:0003221)2.12241217
90Acute encephalopathy (HP:0006846)2.12176707
91Gait imbalance (HP:0002141)2.11315411
92Optic disc pallor (HP:0000543)2.09212046
93Large for gestational age (HP:0001520)2.09073443
94Congenital primary aphakia (HP:0007707)2.08806573
95Leukodystrophy (HP:0002415)2.08706730
96Abnormality of the septum pellucidum (HP:0007375)2.06516355
97Abnormal biliary tract physiology (HP:0012439)2.04940506
98Bile duct proliferation (HP:0001408)2.04940506
99Aplasia/Hypoplasia of the tibia (HP:0005772)2.04422974
100Sensory axonal neuropathy (HP:0003390)2.01884097
101Type I transferrin isoform profile (HP:0003642)2.01881762
102Increased CSF lactate (HP:0002490)2.01343924
103Abnormal drinking behavior (HP:0030082)2.00297041
104Polydipsia (HP:0001959)2.00297041
105Abnormality of the renal collecting system (HP:0004742)1.99908283
106Abnormality of the columella (HP:0009929)1.97174028
107Rhinitis (HP:0012384)1.97167175
108Anencephaly (HP:0002323)1.97034057
109Aplasia/hypoplasia of the uterus (HP:0008684)1.96644418
110Furrowed tongue (HP:0000221)1.96470323
111Hypoplastic pelvis (HP:0008839)1.96245299
112Abnormality of serum amino acid levels (HP:0003112)1.95488936
113Nephrogenic diabetes insipidus (HP:0009806)1.95230509
114Severe visual impairment (HP:0001141)1.95009176
115Attenuation of retinal blood vessels (HP:0007843)1.92060369
116Increased serum pyruvate (HP:0003542)1.91626909
117Abnormality of glycolysis (HP:0004366)1.91626909
118Lethargy (HP:0001254)1.91315375
119Chronic otitis media (HP:0000389)1.90612075
120Congenital ichthyosiform erythroderma (HP:0007431)1.89897288
121Exertional dyspnea (HP:0002875)1.88445890
122Congenital sensorineural hearing impairment (HP:0008527)1.88354142
123Progressive inability to walk (HP:0002505)1.88171881
124Aplasia/Hypoplasia of the tongue (HP:0010295)1.88129880
125Aplasia/Hypoplasia of the uvula (HP:0010293)1.88046752
126Gaze-evoked nystagmus (HP:0000640)1.87371921
127Congenital hepatic fibrosis (HP:0002612)1.86954780
128Abnormal sex determination (HP:0012244)1.86113520
129Sex reversal (HP:0012245)1.86113520
130Hyperglycinuria (HP:0003108)1.85685693
131Partial duplication of the phalanx of hand (HP:0009999)1.85595376
132Nasolacrimal duct obstruction (HP:0000579)1.84179388
133Renal agenesis (HP:0000104)1.83337802
134Small hand (HP:0200055)1.82197522
135Absent thumb (HP:0009777)1.81401552
136Abnormality of the phalanges of the 2nd finger (HP:0009541)1.79695597
137Male pseudohermaphroditism (HP:0000037)1.79454130
138Stomatitis (HP:0010280)1.79115021
139Hypoplasia of the uterus (HP:0000013)1.78176677
140Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.77474244
141Decreased activity of mitochondrial respiratory chain (HP:0008972)1.77474244
142Microretrognathia (HP:0000308)1.76476265
143Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.75941444
144Abnormal protein N-linked glycosylation (HP:0012347)1.75941444
145Abnormal protein glycosylation (HP:0012346)1.75941444
146Abnormal glycosylation (HP:0012345)1.75941444
147Bilateral microphthalmos (HP:0007633)1.75191887
148Split foot (HP:0001839)1.74580278
149Recurrent sinusitis (HP:0011108)1.72804790
150Progressive microcephaly (HP:0000253)1.72536410
151Progressive cerebellar ataxia (HP:0002073)1.72416881
152Supernumerary spleens (HP:0009799)1.71961702
153Glycosuria (HP:0003076)1.71960408
154Abnormality of urine glucose concentration (HP:0011016)1.71960408
155Tubulointerstitial nephritis (HP:0001970)1.71687384
156Triphalangeal thumb (HP:0001199)1.70401509
157Thickened helices (HP:0000391)1.70256750
158Alacrima (HP:0000522)1.69630968
159Morphological abnormality of the inner ear (HP:0011390)1.69049399
160Pancytopenia (HP:0001876)1.68915509
161Hypomagnesemia (HP:0002917)1.67332782
162Decreased central vision (HP:0007663)1.66527263
163Abnormal rod and cone electroretinograms (HP:0008323)1.66492055
164Aplasia cutis congenita (HP:0001057)1.65401209
165Chronic obstructive pulmonary disease (HP:0006510)1.65148062
166Obstructive lung disease (HP:0006536)1.65148062
167IgM deficiency (HP:0002850)1.64806706
168Decreased lacrimation (HP:0000633)1.64737711
169Optic nerve hypoplasia (HP:0000609)1.64429164
170Chronic sinusitis (HP:0011109)1.63342904
171Increased intramyocellular lipid droplets (HP:0012240)1.62876718
172Upper limb muscle weakness (HP:0003484)1.61741112
173Aplastic anemia (HP:0001915)1.61547690

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.92583261
2STK164.26997107
3TNIK4.19247138
4ZAK3.31240293
5STK393.23945327
6CASK2.96063725
7CDK192.61343071
8WNK32.55829888
9MAP4K22.42831419
10OXSR12.41322655
11VRK12.14910345
12PBK2.11859019
13BMPR1B2.08775578
14TAOK32.00491803
15MKNK21.88170960
16BCKDK1.83092261
17MKNK11.82853334
18MAPKAPK51.81473856
19TLK11.78324310
20MAP3K41.75977661
21MAPK151.70518002
22PNCK1.67793435
23NME21.67641686
24ADRBK21.65474323
25GRK71.62348850
26MST41.56695245
27VRK21.53761116
28PKN11.52538646
29BLK1.50962748
30PINK11.50884148
31MUSK1.46036186
32DYRK31.44954352
33CLK11.28378236
34TEC1.26249362
35FES1.24696918
36CSNK1G31.21796687
37YES11.21416862
38GRK11.20928936
39TRIM281.20927383
40DYRK21.18283176
41KIT1.14429858
42SRPK11.13989627
43RPS6KA51.10599981
44TXK1.08608822
45IRAK41.07102504
46EPHB11.06977888
47BCR1.06002963
48EIF2AK21.04034938
49WEE11.00911113
50WNK41.00861636
51BUB11.00536792
52PLK40.99211908
53NEK60.97243116
54CAMK2B0.96092765
55EIF2AK30.95084269
56CSNK1G10.93936366
57NME10.93915892
58FGFR20.93085751
59TESK20.92714293
60CSNK1A1L0.91558167
61BRSK20.91460470
62UHMK10.91352923
63MAPKAPK30.91144539
64CDK30.89880063
65DAPK20.89701798
66FGR0.89284526
67PRKCG0.88127471
68NLK0.86279371
69BRD40.82362268
70LYN0.81610902
71NEK20.80224470
72CSNK1G20.79903365
73CDC70.76584200
74MAP2K70.76504233
75IRAK20.75258377
76PIK3CG0.73698056
77INSRR0.73560071
78PLK10.72262412
79MAP4K10.70397110
80HIPK20.70069921
81ITK0.69565310
82LCK0.69316224
83ACVR1B0.69183329
84PRKCQ0.68976487
85CAMKK20.68284220
86CAMK2D0.67995011
87IRAK10.66585314
88BTK0.66481209
89CHEK20.63887461
90PLK30.63526640
91ATR0.62751122
92PAK30.62108177
93PIK3CA0.61673922
94KDR0.59763102
95MAPK130.59692855
96ROCK20.57503262
97MAP2K60.57156470
98SYK0.56017614
99CCNB10.55997120
100TIE10.55807357
101PDK20.55529074
102NTRK20.55460690
103CDK70.55273836
104FLT30.55008968
105PRKCI0.54686582
106MARK20.50051255
107CAMK2A0.48479841
108CSF1R0.48211986
109MARK10.48197773
110STK38L0.47781975
111ADRBK10.46935435
112WNK10.46843983
113CSNK2A20.46556770
114PIM20.46536469
115NUAK10.46169439
116CAMK10.45448121
117PRKACA0.44237058
118PLK20.43737655
119CSNK1A10.42964556
120PHKG10.42580580
121PHKG20.42580580
122LIMK10.41945480
123ERBB30.40998632
124PRKCE0.40563305
125RIPK40.40295660
126TNK20.40247777
127IKBKB0.39937337
128BMPR20.39573704
129ABL20.38680656
130TAF10.38633807
131MAP2K20.38523563
132STK110.38223732
133AKT30.37713505
134IRAK30.37249513
135PRKG10.37062467
136MAPK40.36273100
137CAMK2G0.35386028
138CSNK2A10.35007418
139EPHA40.34801553
140AURKB0.34799322
141PTK2B0.34054720
142NEK10.33768515
143MET0.33232479
144CSNK1D0.33169181
145MARK30.32623527
146TGFBR10.32258659
147STK40.31991169
148TRPM70.28899125
149AURKA0.27174460

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.77683669
2Protein export_Homo sapiens_hsa030603.17802790
3Oxidative phosphorylation_Homo sapiens_hsa001902.93693954
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.85568177
5Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.68572119
6Fatty acid elongation_Homo sapiens_hsa000622.52831139
7Homologous recombination_Homo sapiens_hsa034402.27837279
8RNA polymerase_Homo sapiens_hsa030202.24232600
9Parkinsons disease_Homo sapiens_hsa050122.22996126
10Non-homologous end-joining_Homo sapiens_hsa034502.17794982
11Ether lipid metabolism_Homo sapiens_hsa005652.02793756
12Mismatch repair_Homo sapiens_hsa034301.95033542
13DNA replication_Homo sapiens_hsa030301.94972402
14Nitrogen metabolism_Homo sapiens_hsa009101.85940333
15Butanoate metabolism_Homo sapiens_hsa006501.85914045
16Fanconi anemia pathway_Homo sapiens_hsa034601.77985921
17Alzheimers disease_Homo sapiens_hsa050101.77004667
18Proteasome_Homo sapiens_hsa030501.73203379
19Sphingolipid metabolism_Homo sapiens_hsa006001.72235078
20Spliceosome_Homo sapiens_hsa030401.71702763
21Selenocompound metabolism_Homo sapiens_hsa004501.69838205
22Huntingtons disease_Homo sapiens_hsa050161.66263651
23Nucleotide excision repair_Homo sapiens_hsa034201.63954257
24Caffeine metabolism_Homo sapiens_hsa002321.59387550
25One carbon pool by folate_Homo sapiens_hsa006701.59305938
26Primary bile acid biosynthesis_Homo sapiens_hsa001201.58261007
27Basal transcription factors_Homo sapiens_hsa030221.55905081
28Pyrimidine metabolism_Homo sapiens_hsa002401.53523862
29Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.52025911
30Steroid biosynthesis_Homo sapiens_hsa001001.50398614
31Tryptophan metabolism_Homo sapiens_hsa003801.47687855
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.40303863
33Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.38754320
34Phototransduction_Homo sapiens_hsa047441.37508391
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.33882787
36Primary immunodeficiency_Homo sapiens_hsa053401.30622619
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.29926948
38Peroxisome_Homo sapiens_hsa041461.29606151
39Linoleic acid metabolism_Homo sapiens_hsa005911.25462561
40Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.21268937
41Chemical carcinogenesis_Homo sapiens_hsa052041.20564992
42Hematopoietic cell lineage_Homo sapiens_hsa046401.18890039
43Propanoate metabolism_Homo sapiens_hsa006401.17777998
44Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.14856378
45Arachidonic acid metabolism_Homo sapiens_hsa005901.10979761
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.09457626
47Autoimmune thyroid disease_Homo sapiens_hsa053201.08355283
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.05675330
49Systemic lupus erythematosus_Homo sapiens_hsa053221.05208447
50Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.05075234
51Purine metabolism_Homo sapiens_hsa002301.02179184
52Nicotine addiction_Homo sapiens_hsa050330.98508047
53Asthma_Homo sapiens_hsa053100.94192635
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.94067126
55Base excision repair_Homo sapiens_hsa034100.93728477
56Serotonergic synapse_Homo sapiens_hsa047260.92992125
57Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.92837124
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.91758657
59Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.90952111
60SNARE interactions in vesicular transport_Homo sapiens_hsa041300.89713205
61alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.88337728
62Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.86693927
63RNA degradation_Homo sapiens_hsa030180.84198496
64Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.83941703
65Olfactory transduction_Homo sapiens_hsa047400.83453264
66Axon guidance_Homo sapiens_hsa043600.82829552
67Pentose and glucuronate interconversions_Homo sapiens_hsa000400.82612931
68Histidine metabolism_Homo sapiens_hsa003400.82316860
69Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80001807
70Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.78964543
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.78804751
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.76127684
73Cysteine and methionine metabolism_Homo sapiens_hsa002700.75943834
74Alcoholism_Homo sapiens_hsa050340.74558138
75Allograft rejection_Homo sapiens_hsa053300.72258291
76Malaria_Homo sapiens_hsa051440.71915450
77Rheumatoid arthritis_Homo sapiens_hsa053230.69837793
78Fat digestion and absorption_Homo sapiens_hsa049750.67133287
79Graft-versus-host disease_Homo sapiens_hsa053320.67037242
80Maturity onset diabetes of the young_Homo sapiens_hsa049500.65677745
81Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.65421821
82Vitamin B6 metabolism_Homo sapiens_hsa007500.62437268
83Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61847254
84Sulfur metabolism_Homo sapiens_hsa009200.61598684
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59905084
86Intestinal immune network for IgA production_Homo sapiens_hsa046720.59652492
87Folate biosynthesis_Homo sapiens_hsa007900.57493757
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55797774
89Metabolic pathways_Homo sapiens_hsa011000.54986398
90Drug metabolism - other enzymes_Homo sapiens_hsa009830.54642876
91beta-Alanine metabolism_Homo sapiens_hsa004100.54329322
92Collecting duct acid secretion_Homo sapiens_hsa049660.52608842
93Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.52517077
94Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52366649
95Cardiac muscle contraction_Homo sapiens_hsa042600.52117556
96Cyanoamino acid metabolism_Homo sapiens_hsa004600.51692617
97NF-kappa B signaling pathway_Homo sapiens_hsa040640.51384788
98Type I diabetes mellitus_Homo sapiens_hsa049400.50619416
99Taste transduction_Homo sapiens_hsa047420.50616147
100Other glycan degradation_Homo sapiens_hsa005110.49692715
101Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48843377
102NOD-like receptor signaling pathway_Homo sapiens_hsa046210.48207498
103Glutamatergic synapse_Homo sapiens_hsa047240.48189998
104Morphine addiction_Homo sapiens_hsa050320.47030613
105Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.46080738
106Cocaine addiction_Homo sapiens_hsa050300.44329897
107Glycerolipid metabolism_Homo sapiens_hsa005610.43434080
108Glutathione metabolism_Homo sapiens_hsa004800.43074153
109Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.43038467
110Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.40272042
111RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.39124569
112Tyrosine metabolism_Homo sapiens_hsa003500.38917652
113Vitamin digestion and absorption_Homo sapiens_hsa049770.37779116
114T cell receptor signaling pathway_Homo sapiens_hsa046600.37282328
115Vibrio cholerae infection_Homo sapiens_hsa051100.37100243
116GABAergic synapse_Homo sapiens_hsa047270.35487813
117Fatty acid degradation_Homo sapiens_hsa000710.34716183
118Pyruvate metabolism_Homo sapiens_hsa006200.34530828
119Sphingolipid signaling pathway_Homo sapiens_hsa040710.34266227
120Ovarian steroidogenesis_Homo sapiens_hsa049130.31917735
121African trypanosomiasis_Homo sapiens_hsa051430.31446459
122Retinol metabolism_Homo sapiens_hsa008300.31153409
123Ras signaling pathway_Homo sapiens_hsa040140.30747174
124Arginine and proline metabolism_Homo sapiens_hsa003300.29588468
125B cell receptor signaling pathway_Homo sapiens_hsa046620.29376408
126Cell cycle_Homo sapiens_hsa041100.28985342
127N-Glycan biosynthesis_Homo sapiens_hsa005100.26590116
128Measles_Homo sapiens_hsa051620.24072770
129Regulation of autophagy_Homo sapiens_hsa041400.23344557
130RNA transport_Homo sapiens_hsa030130.23279478
131Sulfur relay system_Homo sapiens_hsa041220.22836715
132ABC transporters_Homo sapiens_hsa020100.22701302
133Long-term depression_Homo sapiens_hsa047300.21851238
134Steroid hormone biosynthesis_Homo sapiens_hsa001400.21281508

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