MPHOSPH10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is phosphorylated during mitosis. The protein localizes to the nucleolus during interphase and to the chromosomes during M phase. The protein associates with the U3 small nucleolar ribonucleoprotein 60-80S complexes and may be involved in pre-rRNA processing. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)4.81464248
2nuclear pore organization (GO:0006999)4.49160724
3nuclear pore complex assembly (GO:0051292)4.40749140
4protein localization to kinetochore (GO:0034501)4.28379572
5metaphase plate congression (GO:0051310)4.26778271
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.21643322
7ribosome assembly (GO:0042255)4.21313595
8maturation of SSU-rRNA (GO:0030490)4.15445391
9chromatin remodeling at centromere (GO:0031055)4.11751931
10CENP-A containing nucleosome assembly (GO:0034080)4.11674457
11DNA replication checkpoint (GO:0000076)4.10899008
12DNA replication initiation (GO:0006270)4.07404445
13formation of translation preinitiation complex (GO:0001731)4.01882563
14ribosome biogenesis (GO:0042254)4.01760214
15nucleobase biosynthetic process (GO:0046112)4.00961760
16mitotic nuclear envelope disassembly (GO:0007077)3.99243170
17kinetochore organization (GO:0051383)3.95158413
18DNA strand elongation involved in DNA replication (GO:0006271)3.94829074
19establishment of protein localization to mitochondrial membrane (GO:0090151)3.94146731
20purine nucleobase biosynthetic process (GO:0009113)3.90609843
21DNA double-strand break processing (GO:0000729)3.83009963
22maturation of 5.8S rRNA (GO:0000460)3.82413037
23DNA unwinding involved in DNA replication (GO:0006268)3.81536486
24ribonucleoprotein complex biogenesis (GO:0022613)3.79917185
25attachment of spindle microtubules to kinetochore (GO:0008608)3.79882159
26regulation of DNA endoreduplication (GO:0032875)3.79467572
27establishment of chromosome localization (GO:0051303)3.78552217
28ribosomal large subunit biogenesis (GO:0042273)3.76951403
29DNA strand elongation (GO:0022616)3.76732684
30regulation of spindle organization (GO:0090224)3.76648493
31chaperone-mediated protein transport (GO:0072321)3.73651360
32DNA replication-dependent nucleosome assembly (GO:0006335)3.72243004
33DNA replication-dependent nucleosome organization (GO:0034723)3.72243004
34DNA replication-independent nucleosome organization (GO:0034724)3.69903464
35DNA replication-independent nucleosome assembly (GO:0006336)3.69903464
36nuclear envelope disassembly (GO:0051081)3.67984654
37membrane disassembly (GO:0030397)3.67984654
38folic acid-containing compound biosynthetic process (GO:0009396)3.65912436
39protein localization to chromosome, centromeric region (GO:0071459)3.65826606
40regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.65604379
41regulation of mitotic spindle checkpoint (GO:1903504)3.65604379
42IMP biosynthetic process (GO:0006188)3.65071334
43resolution of meiotic recombination intermediates (GO:0000712)3.62668379
44DNA damage response, detection of DNA damage (GO:0042769)3.61543948
45telomere maintenance via semi-conservative replication (GO:0032201)3.61435555
46* rRNA processing (GO:0006364)3.56376018
47ribosomal small subunit assembly (GO:0000028)3.55700666
48pore complex assembly (GO:0046931)3.53039426
49mitotic chromosome condensation (GO:0007076)3.52706981
50histone exchange (GO:0043486)3.52158463
51negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.50472298
52kinetochore assembly (GO:0051382)3.50043757
53negative regulation of DNA-dependent DNA replication (GO:2000104)3.48980738
54telomere maintenance via recombination (GO:0000722)3.48542301
55exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.47273038
56* rRNA metabolic process (GO:0016072)3.45146313
57nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.44925275
58ATP synthesis coupled proton transport (GO:0015986)3.44532599
59energy coupled proton transport, down electrochemical gradient (GO:0015985)3.44532599
60rRNA modification (GO:0000154)3.44235059
61mitotic sister chromatid segregation (GO:0000070)3.43731004
62meiotic chromosome segregation (GO:0045132)3.42642616
63regulation of mitotic spindle organization (GO:0060236)3.42403559
64regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.42138016
65synapsis (GO:0007129)3.40223302
66regulation of centriole replication (GO:0046599)3.39885070
67ribosomal small subunit biogenesis (GO:0042274)3.39317375
68mitotic recombination (GO:0006312)3.38527199
69transcription elongation from RNA polymerase III promoter (GO:0006385)3.37988206
70termination of RNA polymerase III transcription (GO:0006386)3.37988206
71regulation of mitochondrial translation (GO:0070129)3.35557480
72regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.35505958
73IMP metabolic process (GO:0046040)3.34385212
74mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.32202218
75positive regulation of chromosome segregation (GO:0051984)3.32042184
76DNA catabolic process, exonucleolytic (GO:0000738)3.28144350
77positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.28059720
78spindle checkpoint (GO:0031577)3.27391904
79DNA ligation (GO:0006266)3.25333556
80histone mRNA metabolic process (GO:0008334)3.21519764
81telomere maintenance via telomere lengthening (GO:0010833)3.20718199
82DNA topological change (GO:0006265)3.17540805
83telomere maintenance via telomerase (GO:0007004)3.17537999
84regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.16022305
85spliceosomal snRNP assembly (GO:0000387)3.15279562
86replication fork processing (GO:0031297)3.14045216
87sister chromatid segregation (GO:0000819)3.13995913
88negative regulation of ligase activity (GO:0051352)3.13689900
89negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.13689900
90transcription elongation from RNA polymerase I promoter (GO:0006362)3.13410064
91translational initiation (GO:0006413)3.12221092
92translational termination (GO:0006415)3.08518735
93regulation of centrosome cycle (GO:0046605)3.08248111
94protein K6-linked ubiquitination (GO:0085020)3.06809097
95termination of RNA polymerase I transcription (GO:0006363)3.05845110
96mitotic spindle checkpoint (GO:0071174)3.05479923
97spindle assembly checkpoint (GO:0071173)3.04997415
98somatic diversification of immune receptors via somatic mutation (GO:0002566)3.04727579
99somatic hypermutation of immunoglobulin genes (GO:0016446)3.04727579
100pseudouridine synthesis (GO:0001522)3.04353399
101viral transcription (GO:0019083)3.03864004
102negative regulation of chromosome segregation (GO:0051985)3.03778526
103establishment of viral latency (GO:0019043)3.03479884
104negative regulation of mitotic sister chromatid separation (GO:2000816)3.02368265
105negative regulation of mitotic sister chromatid segregation (GO:0033048)3.02368265
106negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.02368265
107negative regulation of sister chromatid segregation (GO:0033046)3.02368265
108mitotic sister chromatid cohesion (GO:0007064)3.02111506
109centriole replication (GO:0007099)3.02031893
110transcription-coupled nucleotide-excision repair (GO:0006283)3.01345841
111regulation of mitotic metaphase/anaphase transition (GO:0030071)3.00932415
112organelle disassembly (GO:1903008)3.00004276
113mitochondrial respiratory chain complex assembly (GO:0033108)2.99454225
114termination of RNA polymerase II transcription (GO:0006369)2.99054753
115regulation of chromosome segregation (GO:0051983)2.99012505
116chromatin assembly or disassembly (GO:0006333)2.98178139
117negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.97588735
118nucleotide-excision repair, DNA gap filling (GO:0006297)2.97511095
119mitotic spindle assembly checkpoint (GO:0007094)2.97475193
120rRNA methylation (GO:0031167)2.97334510
121regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.97271775
122DNA deamination (GO:0045006)2.96980197
123establishment of integrated proviral latency (GO:0075713)2.96612200
124DNA duplex unwinding (GO:0032508)2.96423514
125proteasome assembly (GO:0043248)2.95773835
126DNA geometric change (GO:0032392)2.94291362
127regulation of helicase activity (GO:0051095)2.92905697
128spliceosomal complex assembly (GO:0000245)2.92746980
129mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.91991016
130mitochondrial respiratory chain complex I assembly (GO:0032981)2.91991016
131NADH dehydrogenase complex assembly (GO:0010257)2.91991016
132protein complex biogenesis (GO:0070271)2.91949704
133cellular component biogenesis (GO:0044085)2.91488154
134somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.91048465
135isotype switching (GO:0045190)2.91048465
136somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.91048465
137DNA-templated transcription, termination (GO:0006353)2.90947294
138positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.90811425
139anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.90026959
140respiratory electron transport chain (GO:0022904)2.89983381
141protein targeting to mitochondrion (GO:0006626)2.87941973
142chromosome segregation (GO:0007059)2.86898254
1437-methylguanosine mRNA capping (GO:0006370)2.86219049
144transcription from RNA polymerase I promoter (GO:0006360)2.85952279
145positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.85781289
146positive regulation of mitotic sister chromatid separation (GO:1901970)2.85781289
147positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.85781289
148regulation of mitotic sister chromatid segregation (GO:0033047)2.85522794

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.48773215
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.39362766
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.09272529
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.90727390
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.47093309
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.25276734
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.17972619
8* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.09921795
9* GABP_17652178_ChIP-ChIP_JURKAT_Human3.06811059
10* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.98547811
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.90360229
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.83809035
13* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.76938698
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.69906847
15* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.67456378
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.53901474
17* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.50339421
18VDR_23849224_ChIP-Seq_CD4+_Human2.43809280
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.26141006
20* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.24084261
21XRN2_22483619_ChIP-Seq_HELA_Human2.22436821
22AR_21909140_ChIP-Seq_LNCAP_Human2.21947725
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.20325703
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.18726341
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.08761383
26ELK1_19687146_ChIP-ChIP_HELA_Human2.07010736
27E2F1_21310950_ChIP-Seq_MCF-7_Human2.04309653
28FOXP3_21729870_ChIP-Seq_TREG_Human2.03995797
29MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.03664990
30* DCP1A_22483619_ChIP-Seq_HELA_Human2.01709375
31PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.97419267
32* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.96940492
33* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.96675915
34EWS_26573619_Chip-Seq_HEK293_Human1.92276005
35HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.91027543
36ELF1_17652178_ChIP-ChIP_JURKAT_Human1.88191500
37ZNF274_21170338_ChIP-Seq_K562_Hela1.83768926
38EGR1_19374776_ChIP-ChIP_THP-1_Human1.83340749
39TTF2_22483619_ChIP-Seq_HELA_Human1.81333751
40* GABP_19822575_ChIP-Seq_HepG2_Human1.81112035
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.79426878
42YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.79364834
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.70507174
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.70337494
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.68812699
46NANOG_18555785_ChIP-Seq_MESCs_Mouse1.68440201
47SALL1_21062744_ChIP-ChIP_HESCs_Human1.66560647
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.60854080
49FUS_26573619_Chip-Seq_HEK293_Human1.59021094
50SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.57527019
51KDM5A_27292631_Chip-Seq_BREAST_Human1.53684357
52MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.50754799
53CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.48240718
54PADI4_21655091_ChIP-ChIP_MCF-7_Human1.47861284
55VDR_22108803_ChIP-Seq_LS180_Human1.47510652
56IGF1R_20145208_ChIP-Seq_DFB_Human1.44588525
57ZFX_18555785_ChIP-Seq_MESCs_Mouse1.41878275
58CIITA_25753668_ChIP-Seq_RAJI_Human1.39019966
59TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.38202192
60YY1_21170310_ChIP-Seq_MESCs_Mouse1.36935833
61POU3F2_20337985_ChIP-ChIP_501MEL_Human1.36322431
62ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.36200519
63FLI1_27457419_Chip-Seq_LIVER_Mouse1.35128867
64RBPJ_22232070_ChIP-Seq_NCS_Mouse1.34516824
65HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.34453322
66* SRF_21415370_ChIP-Seq_HL-1_Mouse1.33441001
67NOTCH1_21737748_ChIP-Seq_TLL_Human1.30196820
68* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.25315590
69POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.24463800
70ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.24018731
71SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.23635368
72TP63_19390658_ChIP-ChIP_HaCaT_Human1.23322110
73PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.18823765
74TFEB_21752829_ChIP-Seq_HELA_Human1.18768112
75ERG_20887958_ChIP-Seq_HPC-7_Mouse1.18539307
76HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.16654000
77SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.15748444
78MYC_22102868_ChIP-Seq_BL_Human1.15485796
79TAF15_26573619_Chip-Seq_HEK293_Human1.14987255
80NANOG_16153702_ChIP-ChIP_HESCs_Human1.14197762
81E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13534173
82ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.10855453
83* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.10703152
84STAT3_1855785_ChIP-Seq_MESCs_Mouse1.09821035
85FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.09656696
86SOX2_18555785_ChIP-Seq_MESCs_Mouse1.08509168
87PCGF2_27294783_Chip-Seq_ESCs_Mouse1.07711405
88* CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.06338389
89* MYC_18940864_ChIP-ChIP_HL60_Human1.06086557
90POU5F1_16153702_ChIP-ChIP_HESCs_Human1.06056861
91PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.04489427
92CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.04110613
93SOX2_16153702_ChIP-ChIP_HESCs_Human1.03371277
94* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.00252512
95FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.99753696
96SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.99565828
97GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95553098
98ELK1_22589737_ChIP-Seq_MCF10A_Human0.95278446
99BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.93220790
100DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.93160088
101P300_19829295_ChIP-Seq_ESCs_Human0.92331997
102SPI1_23547873_ChIP-Seq_NB4_Human0.91678304
103CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.91543042
104* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.90099268
105CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.89775140
106DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.88044529
107RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.87862325
108GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.87700901
109IRF1_19129219_ChIP-ChIP_H3396_Human0.85912597
110SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.84700234
111KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.84045947
112KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.84045947
113KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.84045947
114TCF3_18692474_ChIP-Seq_MEFs_Mouse0.80575485
115NANOG_21062744_ChIP-ChIP_HESCs_Human0.79847900
116ELF5_23300383_ChIP-Seq_T47D_Human0.78038934
117IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.76618174
118TP53_22573176_ChIP-Seq_HFKS_Human0.76442761
119CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.75995223
120SOX17_20123909_ChIP-Seq_XEN_Mouse0.74963559
121EZH2_27294783_Chip-Seq_NPCs_Mouse0.74445288
122CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.74340804
123CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.73889725
124ZFP57_27257070_Chip-Seq_ESCs_Mouse0.73412112
125ER_23166858_ChIP-Seq_MCF-7_Human0.72877641
126* NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.72671895
127GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.72242862
128CTBP1_25329375_ChIP-Seq_LNCAP_Human0.72034606
129HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.70920393
130* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.70577138

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.83012428
2MP0010094_abnormal_chromosome_stability4.82834494
3MP0004957_abnormal_blastocyst_morpholog4.57697771
4MP0008057_abnormal_DNA_replication4.50512211
5MP0003111_abnormal_nucleus_morphology4.39800545
6MP0003077_abnormal_cell_cycle4.14958835
7MP0008058_abnormal_DNA_repair3.57745062
8MP0008932_abnormal_embryonic_tissue2.78020994
9MP0008007_abnormal_cellular_replicative2.75805990
10MP0003123_paternal_imprinting2.74849974
11MP0008877_abnormal_DNA_methylation2.62402974
12MP0001730_embryonic_growth_arrest2.46980074
13MP0000350_abnormal_cell_proliferation2.31610942
14MP0002396_abnormal_hematopoietic_system2.14750994
15MP0003718_maternal_effect2.08603301
16MP0010307_abnormal_tumor_latency2.07616143
17MP0001529_abnormal_vocalization2.00622176
18MP0003786_premature_aging1.99376249
19MP0010352_gastrointestinal_tract_polyps1.91360060
20MP0003122_maternal_imprinting1.84062188
21MP0001672_abnormal_embryogenesis/_devel1.80366297
22MP0005380_embryogenesis_phenotype1.80366297
23MP0002938_white_spotting1.79903049
24MP0001697_abnormal_embryo_size1.76731581
25MP0008789_abnormal_olfactory_epithelium1.75861088
26MP0002102_abnormal_ear_morphology1.69063445
27MP0006072_abnormal_retinal_apoptosis1.66382576
28MP0003195_calcinosis1.63120857
29MP0003984_embryonic_growth_retardation1.61118469
30MP0000490_abnormal_crypts_of1.56700216
31MP0002088_abnormal_embryonic_growth/wei1.55929237
32MP0002080_prenatal_lethality1.54089619
33MP0003806_abnormal_nucleotide_metabolis1.52996156
34MP0005084_abnormal_gallbladder_morpholo1.52890300
35MP0002085_abnormal_embryonic_tissue1.52250457
36MP0008995_early_reproductive_senescence1.49827854
37MP0002084_abnormal_developmental_patter1.48325627
38MP0006035_abnormal_mitochondrial_morpho1.43267331
39MP0000313_abnormal_cell_death1.42317929
40MP0002019_abnormal_tumor_incidence1.41980141
41MP0006036_abnormal_mitochondrial_physio1.38716729
42MP0006292_abnormal_olfactory_placode1.38650087
43MP0002086_abnormal_extraembryonic_tissu1.38085873
44MP0003890_abnormal_embryonic-extraembry1.36480509
45MP0009333_abnormal_splenocyte_physiolog1.36013269
46MP0001188_hyperpigmentation1.35458025
47MP0003121_genomic_imprinting1.34943799
48MP0005499_abnormal_olfactory_system1.33550005
49MP0005394_taste/olfaction_phenotype1.33550005
50MP0004197_abnormal_fetal_growth/weight/1.33467291
51MP0002210_abnormal_sex_determination1.29963228
52MP0003763_abnormal_thymus_physiology1.27602310
53MP0004808_abnormal_hematopoietic_stem1.26712445
54MP0002233_abnormal_nose_morphology1.25047777
55MP0005076_abnormal_cell_differentiation1.23558605
56MP0005408_hypopigmentation1.22657333
57MP0003567_abnormal_fetal_cardiomyocyte1.16300734
58MP0001145_abnormal_male_reproductive1.13834705
59MP0000372_irregular_coat_pigmentation1.09940819
60MP0004147_increased_porphyrin_level1.06621793
61MP0001929_abnormal_gametogenesis1.06338088
62MP0003186_abnormal_redox_activity1.05795280
63MP0000703_abnormal_thymus_morphology1.04269339
64MP0000653_abnormal_sex_gland1.03914279
65MP0002398_abnormal_bone_marrow1.02613653
66MP0001293_anophthalmia1.01006211
67MP0003698_abnormal_male_reproductive0.97824557
68MP0003941_abnormal_skin_development0.97390516
69MP0002722_abnormal_immune_system0.95375533
70MP0003937_abnormal_limbs/digits/tail_de0.94308598
71MP0005253_abnormal_eye_physiology0.94150074
72MP0002638_abnormal_pupillary_reflex0.93709528
73MP0001119_abnormal_female_reproductive0.93017374
74MP0005397_hematopoietic_system_phenotyp0.92969307
75MP0001545_abnormal_hematopoietic_system0.92969307
76MP0003315_abnormal_perineum_morphology0.92746721
77MP0009697_abnormal_copulation0.92663730
78MP0000689_abnormal_spleen_morphology0.91792919
79MP0000631_abnormal_neuroendocrine_gland0.89893590
80MP0001984_abnormal_olfaction0.88217161
81MP0000049_abnormal_middle_ear0.85456881
82MP0003136_yellow_coat_color0.85313274
83MP0002160_abnormal_reproductive_system0.84784056
84MP0005621_abnormal_cell_physiology0.84512886
85MP0002697_abnormal_eye_size0.83496070
86MP0005384_cellular_phenotype0.83464130
87MP0002736_abnormal_nociception_after0.82793923
88MP0005551_abnormal_eye_electrophysiolog0.82386476
89MP0001764_abnormal_homeostasis0.82377287
90MP0010030_abnormal_orbit_morphology0.81846583
91MP0004142_abnormal_muscle_tone0.79931055
92MP0001485_abnormal_pinna_reflex0.79909778
93MP0002751_abnormal_autonomic_nervous0.79593427
94MP0002429_abnormal_blood_cell0.79498715
95MP0001915_intracranial_hemorrhage0.77932071
96MP0002163_abnormal_gland_morphology0.77708316
97MP0005389_reproductive_system_phenotype0.77293534
98MP0000858_altered_metastatic_potential0.76722352
99MP0004215_abnormal_myocardial_fiber0.76291271
100MP0005410_abnormal_fertilization0.75973958
101MP0005391_vision/eye_phenotype0.75958217
102MP0002277_abnormal_respiratory_mucosa0.75562913
103MP0005023_abnormal_wound_healing0.75515935
104MP0002111_abnormal_tail_morphology0.74431992
105MP0004133_heterotaxia0.74178545
106MP0003011_delayed_dark_adaptation0.73667608
107MP0008872_abnormal_physiological_respon0.72889530
108MP0002234_abnormal_pharynx_morphology0.72829296
109MP0000716_abnormal_immune_system0.71653855
110MP0009672_abnormal_birth_weight0.70791878
111MP0003755_abnormal_palate_morphology0.70558190
112MP0001853_heart_inflammation0.68753200
113MP0002161_abnormal_fertility/fecundity0.68591761
114MP0001800_abnormal_humoral_immune0.68540672
115MP0002837_dystrophic_cardiac_calcinosis0.68413328
116MP0000358_abnormal_cell_content/0.67718341
117MP0008875_abnormal_xenobiotic_pharmacok0.66504920
118MP0001286_abnormal_eye_development0.66488960
119MP0005645_abnormal_hypothalamus_physiol0.66405712
120MP0003221_abnormal_cardiomyocyte_apopto0.65909647
121MP0009379_abnormal_foot_pigmentation0.65757913
122MP0000432_abnormal_head_morphology0.65509017
123MP0000647_abnormal_sebaceous_gland0.62843939
124MP0002452_abnormal_antigen_presenting0.62831891
125MP0005671_abnormal_response_to0.62582386
126MP0004264_abnormal_extraembryonic_tissu0.61834856
127MP0003119_abnormal_digestive_system0.61409821
128MP0002420_abnormal_adaptive_immunity0.61116838
129MP0003448_altered_tumor_morphology0.60687998
130MP0009703_decreased_birth_body0.60403777
131MP0001819_abnormal_immune_cell0.59935494
132MP0003950_abnormal_plasma_membrane0.59754058
133MP0005395_other_phenotype0.59594128
134MP0002405_respiratory_system_inflammati0.59171770
135MP0000627_abnormal_mammary_gland0.58992005
136MP0003699_abnormal_female_reproductive0.57508594
137MP0001835_abnormal_antigen_presentation0.57386122
138MP0000428_abnormal_craniofacial_morphol0.57176503
139MP0002132_abnormal_respiratory_system0.55763663
140MP0003787_abnormal_imprinting0.55627219
141MP0003936_abnormal_reproductive_system0.55256907
142MP0009053_abnormal_anal_canal0.53622644
143MP0003566_abnormal_cell_adhesion0.53023910
144MP0008260_abnormal_autophagy0.52437921
145MP0001919_abnormal_reproductive_system0.51880268
146MP0002723_abnormal_immune_serum0.51484079
147MP0002006_tumorigenesis0.51227065

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.59951111
2Chromsome breakage (HP:0040012)4.27803927
3Acute necrotizing encephalopathy (HP:0006965)3.88723738
4Breast hypoplasia (HP:0003187)3.83773266
5Chromosomal breakage induced by crosslinking agents (HP:0003221)3.64528093
6Reticulocytopenia (HP:0001896)3.57847367
7Acute encephalopathy (HP:0006846)3.49540915
8Abnormal mitochondria in muscle tissue (HP:0008316)3.41432580
9Agnosia (HP:0010524)3.41076783
10Oral leukoplakia (HP:0002745)3.38141192
11Abnormality of chromosome stability (HP:0003220)3.31811881
12Carpal bone hypoplasia (HP:0001498)3.31716291
13Abnormality of the anterior horn cell (HP:0006802)3.26202680
14Degeneration of anterior horn cells (HP:0002398)3.26202680
15Abnormality of the labia minora (HP:0012880)3.25596061
16Patellar aplasia (HP:0006443)3.22833014
17Increased CSF lactate (HP:0002490)3.19659349
18Progressive macrocephaly (HP:0004481)3.19299516
19Abnormality of cells of the erythroid lineage (HP:0012130)3.19296156
20Increased hepatocellular lipid droplets (HP:0006565)3.16015927
21Aplastic anemia (HP:0001915)3.14177262
22Mitochondrial inheritance (HP:0001427)3.09513869
23Abnormality of the preputium (HP:0100587)3.08409710
24Medulloblastoma (HP:0002885)3.05861720
25Cerebral hypomyelination (HP:0006808)3.03992296
26Aplasia/Hypoplasia of the patella (HP:0006498)3.01525514
27Colon cancer (HP:0003003)2.96118992
28Abnormal number of erythroid precursors (HP:0012131)2.95390451
29Impulsivity (HP:0100710)2.95263184
30Lipid accumulation in hepatocytes (HP:0006561)2.94409799
31Meckel diverticulum (HP:0002245)2.88520230
32Rough bone trabeculation (HP:0100670)2.87213035
33Hepatocellular necrosis (HP:0001404)2.84336771
34Absent radius (HP:0003974)2.82499193
35Methylmalonic acidemia (HP:0002912)2.80517935
36Increased serum pyruvate (HP:0003542)2.77848827
37Abnormality of the ileum (HP:0001549)2.74346965
38Premature graying of hair (HP:0002216)2.73967040
39Cerebral edema (HP:0002181)2.73714502
40Supernumerary spleens (HP:0009799)2.72447289
41Selective tooth agenesis (HP:0001592)2.69502831
42Myelodysplasia (HP:0002863)2.66309071
43Hepatic necrosis (HP:0002605)2.64655163
44Rhabdomyosarcoma (HP:0002859)2.60915915
45Ependymoma (HP:0002888)2.60082459
46Aplasia involving forearm bones (HP:0009822)2.57181962
47Absent forearm bone (HP:0003953)2.57181962
48Aplasia/Hypoplasia of the uvula (HP:0010293)2.47604450
49Volvulus (HP:0002580)2.45907506
50Increased serum lactate (HP:0002151)2.45525872
51Abnormality of glycolysis (HP:0004366)2.44424012
52Absent thumb (HP:0009777)2.44109490
53Premature ovarian failure (HP:0008209)2.44008123
54Sparse lateral eyebrow (HP:0005338)2.43345070
55Microvesicular hepatic steatosis (HP:0001414)2.42111248
56Ectopic kidney (HP:0000086)2.40927385
57Sloping forehead (HP:0000340)2.40850029
58Bone marrow hypocellularity (HP:0005528)2.40849080
59Hyperglycinemia (HP:0002154)2.39710437
60Duodenal stenosis (HP:0100867)2.32982747
61Small intestinal stenosis (HP:0012848)2.32982747
62Macrocytic anemia (HP:0001972)2.32745827
63Pallor (HP:0000980)2.31516963
64Abnormality of methionine metabolism (HP:0010901)2.31417662
65Pancreatic islet-cell hyperplasia (HP:0004510)2.28034201
66Irregular epiphyses (HP:0010582)2.27703620
67Abnormal lung lobation (HP:0002101)2.26454485
68Neoplasm of the pancreas (HP:0002894)2.24913565
69Type I transferrin isoform profile (HP:0003642)2.24566281
70Cellular immunodeficiency (HP:0005374)2.23837906
71Secondary amenorrhea (HP:0000869)2.22697873
72Deviation of the thumb (HP:0009603)2.20166828
73Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.19962810
74Proximal placement of thumb (HP:0009623)2.19906825
75Horseshoe kidney (HP:0000085)2.19460968
76Reduced antithrombin III activity (HP:0001976)2.16243000
77Abnormal trabecular bone morphology (HP:0100671)2.15260767
78Squamous cell carcinoma (HP:0002860)2.12593999
79Atresia of the external auditory canal (HP:0000413)2.10396830
8011 pairs of ribs (HP:0000878)2.10234269
81Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.08434839
82Decreased activity of mitochondrial respiratory chain (HP:0008972)2.08434839
83Facial hemangioma (HP:0000329)2.08274899
84Hypoplasia of the capital femoral epiphysis (HP:0003090)2.07319889
85Molar tooth sign on MRI (HP:0002419)2.06550350
86Abnormality of midbrain morphology (HP:0002418)2.06550350
87Neoplasm of the oral cavity (HP:0100649)2.05833289
88Renal cortical cysts (HP:0000803)2.04711310
89Lymphoma (HP:0002665)2.04706085
90Amaurosis fugax (HP:0100576)2.04670168
91Lactic acidosis (HP:0003128)2.04248746
92Methylmalonic aciduria (HP:0012120)2.03981651
93Abnormality of the pons (HP:0007361)2.03963748
94Hypoplasia of the pons (HP:0012110)2.02265622
95Leukodystrophy (HP:0002415)2.01574770
96Basal cell carcinoma (HP:0002671)2.00483164
97Renal Fanconi syndrome (HP:0001994)2.00071761
98Thrombocytosis (HP:0001894)1.98914246
99Acute myeloid leukemia (HP:0004808)1.98747283
100Stenosis of the external auditory canal (HP:0000402)1.96610415
101Trismus (HP:0000211)1.96348170
102Biliary tract neoplasm (HP:0100574)1.94448669
103Aplasia/Hypoplasia of the sternum (HP:0006714)1.94119246
104Nephroblastoma (Wilms tumor) (HP:0002667)1.93895689
105Abnormality of serum amino acid levels (HP:0003112)1.93464960
106Tracheoesophageal fistula (HP:0002575)1.93251473
107Pancreatic cysts (HP:0001737)1.92806171
108Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.91686161
109Abnormal protein N-linked glycosylation (HP:0012347)1.91686161
110Abnormal protein glycosylation (HP:0012346)1.91686161
111Abnormal glycosylation (HP:0012345)1.91686161
112Spinal muscular atrophy (HP:0007269)1.91079386
113Abnormal number of incisors (HP:0011064)1.90671023
114Abnormality of the duodenum (HP:0002246)1.90405840
115Increased nuchal translucency (HP:0010880)1.90223340
116Cleft eyelid (HP:0000625)1.90201952
117Short thumb (HP:0009778)1.90139883
118Abnormality of the carotid arteries (HP:0005344)1.89862697
119Gonadotropin excess (HP:0000837)1.89336013
120Prominent nose (HP:0000448)1.89276375
121Respiratory failure (HP:0002878)1.88763450
122Multiple enchondromatosis (HP:0005701)1.87703419
123Abnormality of aspartate family amino acid metabolism (HP:0010899)1.87696940
124Abnormal spermatogenesis (HP:0008669)1.87485293
125Triphalangeal thumb (HP:0001199)1.87254944
126Bifid tongue (HP:0010297)1.85643543
127Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.85141949
128Abnormality of alanine metabolism (HP:0010916)1.85141949
129Hyperalaninemia (HP:0003348)1.85141949
130Glossoptosis (HP:0000162)1.84722612
131Abnormality of DNA repair (HP:0003254)1.84395656
132Aplasia/hypoplasia of the humerus (HP:0006507)1.84282485
133Microretrognathia (HP:0000308)1.83063567
134Exercise intolerance (HP:0003546)1.83010317
135Neoplasm of the colon (HP:0100273)1.82655942
136Pulmonary fibrosis (HP:0002206)1.82492120
137Pancreatic fibrosis (HP:0100732)1.81991068
138CNS hypomyelination (HP:0003429)1.80185725
139Absent epiphyses (HP:0010577)1.80164949
140Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.80164949
141Cafe-au-lait spot (HP:0000957)1.78745215
142Embryonal renal neoplasm (HP:0011794)1.77643643
143Duplicated collecting system (HP:0000081)1.75974242
144Increased intramyocellular lipid droplets (HP:0012240)1.74719406
145Optic disc pallor (HP:0000543)1.73616873
146Pancytopenia (HP:0001876)1.72904983
147Slender long bone (HP:0003100)1.72206427
148Oligodactyly (hands) (HP:0001180)1.70923845
149Short tibia (HP:0005736)1.70062052
150Hypoplasia of the radius (HP:0002984)1.70058577
151Lethargy (HP:0001254)1.69782966
152Clubbing of toes (HP:0100760)1.68007050
153Small epiphyses (HP:0010585)1.67956101
154Entropion (HP:0000621)1.67511641
155Abnormality of the renal cortex (HP:0011035)1.66711195
156Abnormality of glycine metabolism (HP:0010895)1.65491129
157Abnormality of serine family amino acid metabolism (HP:0010894)1.65491129
158Asplenia (HP:0001746)1.65452157
159Medial flaring of the eyebrow (HP:0010747)1.65038669
160Prolonged partial thromboplastin time (HP:0003645)1.64686569
161Hyperglycinuria (HP:0003108)1.63149116
162Hypoglycemic coma (HP:0001325)1.63073126

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.52551800
2BUB14.26046845
3WEE13.91621882
4EIF2AK13.55055294
5SRPK13.08126096
6TSSK62.70779395
7TRIM282.63220663
8PLK42.62962558
9EIF2AK32.60658646
10TTK2.59872808
11NEK22.38244380
12ACVR1B2.31648587
13VRK22.23726890
14PLK12.09484221
15PLK32.07501709
16MKNK12.00622403
17NME21.93917387
18BRSK21.91407225
19CDK121.80656455
20NEK11.77940316
21VRK11.76741498
22* AURKB1.74611391
23TESK21.73944814
24ATR1.69092047
25TNIK1.63682456
26TAF11.63227633
27PBK1.60488038
28MKNK21.59820877
29STK101.59279195
30CDK71.55520307
31TLK11.51959860
32CHEK21.50759316
33RPS6KB21.46873753
34WNK31.45832510
35RPS6KA41.44657236
36CHEK11.43006920
37PNCK1.41267599
38MAP3K81.36825974
39BCR1.36110817
40BMPR1B1.36027031
41PASK1.34428749
42STK161.25474659
43ZAK1.20464518
44AURKA1.19177046
45ERBB31.15269636
46EPHA21.11217715
47DYRK31.10873682
48ATM1.09065449
49MAP4K21.08588716
50STK38L1.08421607
51MST41.08410432
52CDK41.07793229
53STK41.07461018
54STK391.06687367
55CDK80.94909414
56STK30.93992641
57MAP3K40.93512646
58TGFBR10.92847313
59BRSK10.91970930
60PIM10.90558930
61CDK20.90320246
62MELK0.89211655
63BRAF0.88119154
64CSNK2A20.84330417
65NME10.83022885
66EIF2AK20.81231706
67WNK40.80106005
68PIM20.78213374
69ALK0.73792097
70TXK0.73655590
71MAP3K120.73163826
72CSNK2A10.72565228
73CCNB10.71920161
74BRD40.70186497
75CDK10.69516083
76MAP4K10.69300520
77LATS10.69101573
78CDK60.66670651
79CASK0.65354651
80FGFR10.65253384
81EEF2K0.62302765
82OXSR10.61792964
83RPS6KA50.61344759
84CLK10.59433022
85PAK10.58680129
86CSNK1G10.57288779
87CDK30.56872056
88PAK40.56457556
89CSNK1E0.53340375
90TEC0.52977814
91SCYL20.51880132
92FRK0.50904336
93GRK10.49601573
94LATS20.47620136
95MUSK0.44037326
96NLK0.43473703
97AKT30.43367428
98PRKCG0.42650618
99CDK90.42002369
100PRKCI0.40780855
101MAP2K70.39097382
102LRRK20.38853370
103RAF10.38467853
104SIK30.38362005
105PRKDC0.38117885
106NUAK10.32891846
107IRAK40.31412473
108BCKDK0.30866143
109PDK20.30784015
110CSNK1D0.30471464
111TESK10.30006939
112MAPKAPK30.29982061
113MARK30.29436036
114CSNK1G30.28893751
115PIK3CA0.28686582
116PRKCE0.28533841
117PRKACB0.28517826
118CSNK1G20.28484634
119PAK30.28400530
120MAPK140.28205866
121INSRR0.27499238
122JAK30.27082317
123PLK20.26726965
124CSNK1A1L0.26722587
125MAPK130.26363448
126MAP3K60.25737270
127MAP3K50.24244453
128PDK30.24181257
129PDK40.24181257
130ERBB40.23053250
131CHUK0.23034309
132MAP3K30.22507457
133MTOR0.22444204
134ABL20.21630397
135DYRK20.21138123
136IKBKB0.20809420
137BTK0.20631938

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.26152309
2DNA replication_Homo sapiens_hsa030304.15949889
3Mismatch repair_Homo sapiens_hsa034303.87088835
4RNA polymerase_Homo sapiens_hsa030203.64595691
5RNA transport_Homo sapiens_hsa030133.35616830
6Spliceosome_Homo sapiens_hsa030403.33225729
7Proteasome_Homo sapiens_hsa030503.28305226
8Ribosome_Homo sapiens_hsa030103.18359999
9Homologous recombination_Homo sapiens_hsa034402.95615239
10Nucleotide excision repair_Homo sapiens_hsa034202.83004909
11Cell cycle_Homo sapiens_hsa041102.72478846
12Oxidative phosphorylation_Homo sapiens_hsa001902.66907094
13One carbon pool by folate_Homo sapiens_hsa006702.63098978
14Base excision repair_Homo sapiens_hsa034102.62767497
15Non-homologous end-joining_Homo sapiens_hsa034502.52179009
16Basal transcription factors_Homo sapiens_hsa030222.48781415
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.46335033
18RNA degradation_Homo sapiens_hsa030182.31200288
19Fanconi anemia pathway_Homo sapiens_hsa034602.29095896
20Pyrimidine metabolism_Homo sapiens_hsa002402.28315976
21Propanoate metabolism_Homo sapiens_hsa006401.85917910
22mRNA surveillance pathway_Homo sapiens_hsa030151.81046899
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.68627623
24p53 signaling pathway_Homo sapiens_hsa041151.61174663
25Alzheimers disease_Homo sapiens_hsa050101.41000968
26Pyruvate metabolism_Homo sapiens_hsa006201.40429987
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.38805804
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.35640069
29Steroid biosynthesis_Homo sapiens_hsa001001.35509540
30Epstein-Barr virus infection_Homo sapiens_hsa051691.30944770
31Purine metabolism_Homo sapiens_hsa002301.29298372
32Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.23847323
33Systemic lupus erythematosus_Homo sapiens_hsa053221.20860059
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.17153621
35Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.15099669
36Vitamin B6 metabolism_Homo sapiens_hsa007501.14280762
37Antigen processing and presentation_Homo sapiens_hsa046121.12713785
38Protein export_Homo sapiens_hsa030601.08069525
39Herpes simplex infection_Homo sapiens_hsa051681.04755973
40Viral carcinogenesis_Homo sapiens_hsa052030.96603926
41Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.92190235
42Oocyte meiosis_Homo sapiens_hsa041140.88522341
43Butanoate metabolism_Homo sapiens_hsa006500.82221277
44Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.79477309
45Cardiac muscle contraction_Homo sapiens_hsa042600.79416997
46Fatty acid elongation_Homo sapiens_hsa000620.76979275
47Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.76725370
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.74877644
49Folate biosynthesis_Homo sapiens_hsa007900.74787095
50Pentose phosphate pathway_Homo sapiens_hsa000300.74144245
51Graft-versus-host disease_Homo sapiens_hsa053320.69642090
52Cysteine and methionine metabolism_Homo sapiens_hsa002700.69285798
53HTLV-I infection_Homo sapiens_hsa051660.67312635
54Legionellosis_Homo sapiens_hsa051340.67206484
55MicroRNAs in cancer_Homo sapiens_hsa052060.63581625
56Primary immunodeficiency_Homo sapiens_hsa053400.62461819
57Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.62169823
58Allograft rejection_Homo sapiens_hsa053300.61177911
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60811572
60Biosynthesis of amino acids_Homo sapiens_hsa012300.59609173
61NF-kappa B signaling pathway_Homo sapiens_hsa040640.59304675
62Circadian rhythm_Homo sapiens_hsa047100.58399880
63Cyanoamino acid metabolism_Homo sapiens_hsa004600.58326058
64Peroxisome_Homo sapiens_hsa041460.58286812
65Phototransduction_Homo sapiens_hsa047440.56746420
66Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.56097259
67Thyroid cancer_Homo sapiens_hsa052160.56051938
68Pentose and glucuronate interconversions_Homo sapiens_hsa000400.55223749
69Selenocompound metabolism_Homo sapiens_hsa004500.54511089
70TGF-beta signaling pathway_Homo sapiens_hsa043500.53523682
71Measles_Homo sapiens_hsa051620.52364611
72Sulfur metabolism_Homo sapiens_hsa009200.51234090
73Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51181111
74NOD-like receptor signaling pathway_Homo sapiens_hsa046210.50800238
75Regulation of autophagy_Homo sapiens_hsa041400.50455295
76Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.49520571
77Transcriptional misregulation in cancer_Homo sapiens_hsa052020.47800737
78Fatty acid metabolism_Homo sapiens_hsa012120.47652857
79Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47109944
80Small cell lung cancer_Homo sapiens_hsa052220.45426368
81Maturity onset diabetes of the young_Homo sapiens_hsa049500.45372510
82Huntingtons disease_Homo sapiens_hsa050160.43941874
83Vitamin digestion and absorption_Homo sapiens_hsa049770.43867419
84Fatty acid degradation_Homo sapiens_hsa000710.43573577
85beta-Alanine metabolism_Homo sapiens_hsa004100.42643591
86Apoptosis_Homo sapiens_hsa042100.42428347
87Asthma_Homo sapiens_hsa053100.41247869
88Autoimmune thyroid disease_Homo sapiens_hsa053200.39772376
89Glutathione metabolism_Homo sapiens_hsa004800.38144719
90Retinol metabolism_Homo sapiens_hsa008300.36466706
91Hepatitis B_Homo sapiens_hsa051610.36323896
92Hematopoietic cell lineage_Homo sapiens_hsa046400.35755075
93Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.35390552
94Intestinal immune network for IgA production_Homo sapiens_hsa046720.34745611
95Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34642680
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.33743834
97Drug metabolism - other enzymes_Homo sapiens_hsa009830.33716587
98Influenza A_Homo sapiens_hsa051640.33266897
99Type I diabetes mellitus_Homo sapiens_hsa049400.32676367
100Nitrogen metabolism_Homo sapiens_hsa009100.30079771
101Colorectal cancer_Homo sapiens_hsa052100.29673905
102Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.28611772
103Shigellosis_Homo sapiens_hsa051310.28176711
104HIF-1 signaling pathway_Homo sapiens_hsa040660.27875440
105Alcoholism_Homo sapiens_hsa050340.27746065
106Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.27371773
107Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.26897089
108Hippo signaling pathway_Homo sapiens_hsa043900.26613674
109Arginine and proline metabolism_Homo sapiens_hsa003300.24299058
110RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.23991408
111Tryptophan metabolism_Homo sapiens_hsa003800.23941860
112Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.23812253
113Prostate cancer_Homo sapiens_hsa052150.22969896
114Steroid hormone biosynthesis_Homo sapiens_hsa001400.22915575
115Primary bile acid biosynthesis_Homo sapiens_hsa001200.22343924
116Viral myocarditis_Homo sapiens_hsa054160.21843007
117Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.20968872
118N-Glycan biosynthesis_Homo sapiens_hsa005100.19798447
119Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.19231307
120Wnt signaling pathway_Homo sapiens_hsa043100.19053319
121Pathways in cancer_Homo sapiens_hsa052000.17472109
122Arachidonic acid metabolism_Homo sapiens_hsa005900.16983577
123Olfactory transduction_Homo sapiens_hsa047400.16926220
124Chemical carcinogenesis_Homo sapiens_hsa052040.16728997
125Carbon metabolism_Homo sapiens_hsa012000.16501669
126Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.16308940
127Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.16278607
128Leishmaniasis_Homo sapiens_hsa051400.14670511
129Jak-STAT signaling pathway_Homo sapiens_hsa046300.14570452
130Metabolic pathways_Homo sapiens_hsa011000.13892928
131Renin-angiotensin system_Homo sapiens_hsa046140.13386152
132Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.13030824
133Adherens junction_Homo sapiens_hsa045200.11715308
134T cell receptor signaling pathway_Homo sapiens_hsa046600.11622013
135Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.11211485
136Fat digestion and absorption_Homo sapiens_hsa049750.11021415
137Caffeine metabolism_Homo sapiens_hsa002320.10947759
138Pancreatic cancer_Homo sapiens_hsa052120.10246116
139Sulfur relay system_Homo sapiens_hsa041220.10216664
140Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.10203836
141Lysine degradation_Homo sapiens_hsa003100.10018318
142mTOR signaling pathway_Homo sapiens_hsa041500.09828400
143Fructose and mannose metabolism_Homo sapiens_hsa000510.09185870
144Parkinsons disease_Homo sapiens_hsa050120.09151186
145Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.09030602
146Melanoma_Homo sapiens_hsa052180.08831770
147Taste transduction_Homo sapiens_hsa047420.08592110
148Tyrosine metabolism_Homo sapiens_hsa003500.07892156
149Nicotine addiction_Homo sapiens_hsa050330.07886698

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