MPG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.83660736
2viral transcription (GO:0019083)5.56732219
3translational termination (GO:0006415)5.40348964
4DNA deamination (GO:0045006)5.27459095
5maturation of SSU-rRNA (GO:0030490)5.22586047
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.96737410
7ribosomal small subunit biogenesis (GO:0042274)4.88665265
8cotranslational protein targeting to membrane (GO:0006613)4.83078979
9protein targeting to ER (GO:0045047)4.80292121
10translational elongation (GO:0006414)4.65834478
11ribosomal large subunit biogenesis (GO:0042273)4.53403769
12protein localization to endoplasmic reticulum (GO:0070972)4.50806090
13establishment of protein localization to endoplasmic reticulum (GO:0072599)4.49673434
14rRNA modification (GO:0000154)4.41654251
15pinocytosis (GO:0006907)4.28823274
16viral life cycle (GO:0019058)4.26017127
17nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.25246665
18GDP-mannose metabolic process (GO:0019673)4.24878543
19cellular protein complex disassembly (GO:0043624)4.24477128
20translational initiation (GO:0006413)4.22449352
21UV protection (GO:0009650)4.19730910
22protein maturation by protein folding (GO:0022417)4.15293487
23negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.09275799
24protein deneddylation (GO:0000338)4.06746202
25rRNA methylation (GO:0031167)4.05792200
26proteasome assembly (GO:0043248)4.02404127
27DNA strand elongation involved in DNA replication (GO:0006271)3.96165744
28translation (GO:0006412)3.90504890
29cullin deneddylation (GO:0010388)3.89896246
30protein retention in ER lumen (GO:0006621)3.87587179
31deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.86178994
32ribonucleoprotein complex biogenesis (GO:0022613)3.85963801
33telomere maintenance via semi-conservative replication (GO:0032201)3.81725830
34negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.79819288
35protein complex disassembly (GO:0043241)3.76150255
36DNA strand elongation (GO:0022616)3.73792946
37pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.69926051
38mature B cell differentiation involved in immune response (GO:0002313)3.69674167
39Golgi transport vesicle coating (GO:0048200)3.69385526
40COPI coating of Golgi vesicle (GO:0048205)3.69385526
41formation of translation preinitiation complex (GO:0001731)3.68579462
42RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.65850406
43tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.65850406
44maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.59914223
45macromolecular complex disassembly (GO:0032984)3.58634538
46termination of RNA polymerase III transcription (GO:0006386)3.58426406
47transcription elongation from RNA polymerase III promoter (GO:0006385)3.58426406
48proline biosynthetic process (GO:0006561)3.57748077
49DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.57058687
507-methylguanosine mRNA capping (GO:0006370)3.56828550
51rRNA processing (GO:0006364)3.55288791
52barbed-end actin filament capping (GO:0051016)3.51135154
53spliceosomal complex assembly (GO:0000245)3.49451823
54signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.49302768
55intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.49302768
56regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.49208250
57negative regulation of ligase activity (GO:0051352)3.48153716
58negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.48153716
59positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.46966391
60RNA capping (GO:0036260)3.46794875
617-methylguanosine RNA capping (GO:0009452)3.46794875
62signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.46312923
63signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.46312923
64signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.46312923
65transcription-coupled nucleotide-excision repair (GO:0006283)3.46032819
66telomere maintenance via recombination (GO:0000722)3.44447741
67regulation of cellular amino acid metabolic process (GO:0006521)3.43938700
68negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.41085868
69spliceosomal snRNP assembly (GO:0000387)3.41040785
70nuclear-transcribed mRNA catabolic process (GO:0000956)3.40475912
71viral mRNA export from host cell nucleus (GO:0046784)3.40403247
72DNA replication checkpoint (GO:0000076)3.40155006
73anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.39653314
74rRNA metabolic process (GO:0016072)3.37676352
75signal transduction involved in DNA integrity checkpoint (GO:0072401)3.35260292
76signal transduction involved in DNA damage checkpoint (GO:0072422)3.35260292
77cellular component biogenesis (GO:0044085)3.35017617
78Arp2/3 complex-mediated actin nucleation (GO:0034314)3.31466975
79establishment of integrated proviral latency (GO:0075713)3.30317453
80signal transduction involved in cell cycle checkpoint (GO:0072395)3.30143791
81purine nucleobase biosynthetic process (GO:0009113)3.29386212
82antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.29272988
83ribosome biogenesis (GO:0042254)3.29246849
84* deoxyribonucleotide catabolic process (GO:0009264)3.28370425
85nucleobase biosynthetic process (GO:0046112)3.28036216
86negative regulation of B cell apoptotic process (GO:0002903)3.26179356
87mRNA catabolic process (GO:0006402)3.25899084
88regulation of mitochondrial translation (GO:0070129)3.24271858
89mitochondrial respiratory chain complex assembly (GO:0033108)3.21250134
90pentose-phosphate shunt (GO:0006098)3.20372703
91pseudouridine synthesis (GO:0001522)3.19723565
92* deoxyribose phosphate catabolic process (GO:0046386)3.18830906
93exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.18624989
94CENP-A containing nucleosome assembly (GO:0034080)3.18030643
95nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.16758179
96telomere maintenance via telomere lengthening (GO:0010833)3.15279234
97DNA replication initiation (GO:0006270)3.14411724
98* purine deoxyribonucleotide catabolic process (GO:0009155)3.12841775
99RNA catabolic process (GO:0006401)3.09912151
100mitotic recombination (GO:0006312)3.09325894
101chromatin remodeling at centromere (GO:0031055)3.07837844
102antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.07105747
103mitochondrial respiratory chain complex I assembly (GO:0032981)3.06827857
104NADH dehydrogenase complex assembly (GO:0010257)3.06827857
105mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.06827857
106protein complex biogenesis (GO:0070271)3.03248820
107protein targeting to membrane (GO:0006612)3.02696209
108pyrimidine nucleotide catabolic process (GO:0006244)2.99892988
109negative regulation of cell size (GO:0045792)2.99474330
110nucleotide-excision repair, DNA gap filling (GO:0006297)2.97933024
111folic acid-containing compound biosynthetic process (GO:0009396)2.97818383
112nucleotide salvage (GO:0043173)2.96716081
113regulation of mammary gland epithelial cell proliferation (GO:0033599)2.94829434
114positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.94088419
115pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.93556216
116iron-sulfur cluster assembly (GO:0016226)2.91175184
117metallo-sulfur cluster assembly (GO:0031163)2.91175184
118transcription from RNA polymerase I promoter (GO:0006360)2.89909464
119glucose catabolic process (GO:0006007)2.89474079
120DNA damage response, detection of DNA damage (GO:0042769)2.87219204
121DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.87129089
122positive regulation of cell cycle arrest (GO:0071158)2.86554635
123folic acid metabolic process (GO:0046655)2.86487106
124cell cycle G1/S phase transition (GO:0044843)2.85354316
125G1/S transition of mitotic cell cycle (GO:0000082)2.85354316
126positive regulation of viral transcription (GO:0050434)2.84148009
127peptidyl-arginine omega-N-methylation (GO:0035247)2.83888002
128chaperone-mediated protein transport (GO:0072321)2.83419220
129type B pancreatic cell proliferation (GO:0044342)2.77709513
130chaperone mediated protein folding requiring cofactor (GO:0051085)2.77171827
131hyaluronan catabolic process (GO:0030214)2.75540630
132viral protein processing (GO:0019082)2.75049414
133guanosine-containing compound biosynthetic process (GO:1901070)2.74683000
134virion assembly (GO:0019068)2.73173969
1352-deoxyribonucleotide biosynthetic process (GO:0009265)2.69638942
136deoxyribose phosphate biosynthetic process (GO:0046385)2.69638942
137prostanoid biosynthetic process (GO:0046457)2.69416105
138prostaglandin biosynthetic process (GO:0001516)2.69416105
139NADPH regeneration (GO:0006740)2.69002613
140autophagic vacuole fusion (GO:0000046)2.68052138
141negative regulation of erythrocyte differentiation (GO:0045647)2.68007975
142pentose metabolic process (GO:0019321)2.67959574
143mitotic nuclear envelope reassembly (GO:0007084)2.66917314
144nuclear envelope reassembly (GO:0031468)2.66917314
145positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.66705783
1462-deoxyribonucleotide metabolic process (GO:0009394)2.63439374
147deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.62076778
148purine nucleotide salvage (GO:0032261)2.61746443
149purine ribonucleotide transport (GO:0015868)2.60949706
150retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.58002534
151lipopolysaccharide biosynthetic process (GO:0009103)2.57413239
152* deoxyribose phosphate metabolic process (GO:0019692)2.55103872
153immunoglobulin mediated immune response (GO:0016064)2.55042731
154regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.54045602
155response to peptidoglycan (GO:0032494)2.52503367
156oxidative phosphorylation (GO:0006119)2.49620169
157negative regulation of nitric oxide biosynthetic process (GO:0045019)2.49531428
158nucleobase-containing small molecule interconversion (GO:0015949)2.49107180
159adenine nucleotide transport (GO:0051503)2.46458682
160galactose catabolic process (GO:0019388)2.45340863
161pyrimidine nucleoside salvage (GO:0043097)2.42413657
162pyrimidine-containing compound salvage (GO:0008655)2.42413657
163GTP biosynthetic process (GO:0006183)2.41629736
164pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.40939915
165actin nucleation (GO:0045010)2.40470709
166regulation of release of cytochrome c from mitochondria (GO:0090199)2.39782123
167extracellular fibril organization (GO:0043206)2.38567734
168regulation of B cell apoptotic process (GO:0002902)2.38235009
169negative regulation of myeloid cell apoptotic process (GO:0033033)2.37616927
170* purine deoxyribonucleotide metabolic process (GO:0009151)2.37338111
171proline metabolic process (GO:0006560)2.37132799
172response to interferon-beta (GO:0035456)2.35873886
173lipopolysaccharide metabolic process (GO:0008653)2.35761672
174heme biosynthetic process (GO:0006783)2.35631649
175UTP biosynthetic process (GO:0006228)2.31114511
176nucleoside diphosphate biosynthetic process (GO:0009133)2.26479618
177pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.26291589
178CTP metabolic process (GO:0046036)2.25196290
179CTP biosynthetic process (GO:0006241)2.25196290
180regulation of mast cell degranulation (GO:0043304)2.24984731
181regulation of mitochondrial membrane potential (GO:0051881)2.24778455
182fibril organization (GO:0097435)2.24240975
183positive regulation of B cell differentiation (GO:0045579)2.23326018
184UTP metabolic process (GO:0046051)2.22402377
185purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.21464743
186pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.18514931

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.99345377
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.38210915
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.01948946
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.96891259
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.89524257
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.76431578
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.63807908
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.41789872
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.25293505
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.06122147
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.03012395
12CREB1_15753290_ChIP-ChIP_HEK293T_Human3.00497029
13VDR_21846776_ChIP-Seq_THP-1_Human2.92213728
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.91999795
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.88972483
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.82639411
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.76297797
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.70527770
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.64640841
20VDR_23849224_ChIP-Seq_CD4+_Human2.64229608
21XRN2_22483619_ChIP-Seq_HELA_Human2.59262002
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.56928366
23RARG_19884340_ChIP-ChIP_MEFs_Mouse2.55488436
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.43020202
25DCP1A_22483619_ChIP-Seq_HELA_Human2.42522029
26* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.40946273
27PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.40598520
28FOXP3_21729870_ChIP-Seq_TREG_Human2.38413353
29* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.37021646
30* LXR_22292898_ChIP-Seq_THP-1_Human2.33314967
31BP1_19119308_ChIP-ChIP_Hs578T_Human2.33291498
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.28272319
33* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.26163389
34ELK3_25401928_ChIP-Seq_HUVEC_Human2.21728676
35THAP11_20581084_ChIP-Seq_MESCs_Mouse2.16376595
36NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.11251075
37SRF_21415370_ChIP-Seq_HL-1_Mouse2.11126132
38SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.09681341
39TTF2_22483619_ChIP-Seq_HELA_Human2.06138321
40MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.01951247
41FOXM1_23109430_ChIP-Seq_U2OS_Human2.01553945
42GABP_19822575_ChIP-Seq_HepG2_Human2.00546741
43CIITA_25753668_ChIP-Seq_RAJI_Human1.98551789
44PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.96675730
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.94519089
46ELK1_19687146_ChIP-ChIP_HELA_Human1.94398542
47ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.91019702
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.85717829
49MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.85295811
50YY1_21170310_ChIP-Seq_MESCs_Mouse1.84151363
51ZNF263_19887448_ChIP-Seq_K562_Human1.81477776
52PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81191486
53* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.79798291
54* TET1_21451524_ChIP-Seq_MESCs_Mouse1.77139296
55FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.75579370
56CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.73312036
57VDR_24763502_ChIP-Seq_THP-1_Human1.72003171
58HOXB4_20404135_ChIP-ChIP_EML_Mouse1.71179177
59E2F1_21310950_ChIP-Seq_MCF-7_Human1.65392188
60* RACK7_27058665_Chip-Seq_MCF-7_Human1.65240096
61NOTCH1_21737748_ChIP-Seq_TLL_Human1.64812485
62* P68_20966046_ChIP-Seq_HELA_Human1.61903645
63* ELF1_20517297_ChIP-Seq_JURKAT_Human1.61645416
64MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.60611375
65* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.59528539
66MYCN_18555785_ChIP-Seq_MESCs_Mouse1.59036666
67TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.57958551
68YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56942593
69BCL6_27268052_Chip-Seq_Bcells_Human1.56412948
70* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.53034492
71CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.49434878
72AR_21909140_ChIP-Seq_LNCAP_Human1.48886908
73POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.48861700
74THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.46084774
75* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.44671347
76MAF_26560356_Chip-Seq_TH1_Human1.41125877
77MAF_26560356_Chip-Seq_TH2_Human1.38392302
78CTCF_27219007_Chip-Seq_ERYTHROID_Human1.37793736
79BCOR_27268052_Chip-Seq_Bcells_Human1.37558894
80NANOG_18555785_ChIP-Seq_MESCs_Mouse1.37516188
81SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.37117426
82CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.36894730
83KDM2B_26808549_Chip-Seq_SUP-B15_Human1.36632530
84* UTX_26944678_Chip-Seq_JUKART_Human1.34921824
85MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.33742625
86* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.33124823
87* SA1_27219007_Chip-Seq_ERYTHROID_Human1.32793554
88ELK1_22589737_ChIP-Seq_MCF10A_Human1.31921903
89PADI4_21655091_ChIP-ChIP_MCF-7_Human1.31412074
90IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.31223826
91ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.30290810
92TP63_17297297_ChIP-ChIP_HaCaT_Human1.28938104
93SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.28820806
94CTCF_18555785_ChIP-Seq_MESCs_Mouse1.28439583
95CTCF_26484167_Chip-Seq_Bcells_Mouse1.28387367
96MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.26801770
97PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.26316636
98CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.23774572
99* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23638365
100RUNX1_22412390_ChIP-Seq_EML_Mouse1.23514729
101* KDM2B_26808549_Chip-Seq_DND41_Human1.23347066
102RBPJ_22232070_ChIP-Seq_NCS_Mouse1.20221805
103* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.20190176
104PU.1_20513432_ChIP-Seq_Bcells_Mouse1.20021162
105TP63_19390658_ChIP-ChIP_HaCaT_Human1.19500258
106NCOR1_26117541_ChIP-Seq_K562_Human1.19028676
107DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.18436000
108BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.17815672
109FOXP1_21924763_ChIP-Seq_HESCs_Human1.14767194
110GATA1_22383799_ChIP-Seq_G1ME_Mouse1.14288928
111ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.14228922
112TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13123556
113MYC_18940864_ChIP-ChIP_HL60_Human1.13057600
114E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.12046210
115CTCF_21964334_Chip-Seq_Bcells_Human1.11302788
116TCF7_22412390_ChIP-Seq_EML_Mouse1.11065589
117UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.11036291
118CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.10088569
119* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.09933880
120IRF1_19129219_ChIP-ChIP_H3396_Human1.09146047
121* SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.09143963
122KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.08686718
123* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.08561287
124PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.08440747
125KDM5A_27292631_Chip-Seq_BREAST_Human1.08385600
126STAT4_19710469_ChIP-ChIP_TH1__Mouse1.07538406
127ATF3_27146783_Chip-Seq_COLON_Human1.07442062
128SCL_19346495_ChIP-Seq_HPC-7_Human1.07407884
129SOX2_18555785_ChIP-Seq_MESCs_Mouse1.06502051
130RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.05941439
131* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04469882
132* PHF8_20622854_ChIP-Seq_HELA_Human1.04240488
133* E2F1_20622854_ChIP-Seq_HELA_Human1.03691493
134RARB_24833708_ChIP-Seq_LIVER_Mouse1.02515666
135HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.99846256
136ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.97903903
137CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.95173401
138GATA1_22025678_ChIP-Seq_K562_Human0.94726835
139SPI1_23547873_ChIP-Seq_NB4_Human0.94420006
140HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.92726014
141IRF8_22096565_ChIP-ChIP_GC-B_Human0.92523046
142TFEB_21752829_ChIP-Seq_HELA_Human0.91804558
143CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.91217972
144E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.89923669
145SRY_22984422_ChIP-ChIP_TESTIS_Rat0.89486471
146HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.89405914
147* MYC_22102868_ChIP-Seq_BL_Human0.88104345
148CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.88007037
149STAT3_1855785_ChIP-Seq_MESCs_Mouse0.87700264
150POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.85261421
151DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.84947876
152RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.83724327
153FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82916705
154KLF4_18555785_ChIP-Seq_MESCs_Mouse0.80291276
155IRF8_21731497_ChIP-ChIP_J774_Mouse0.77885790
156KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.75748956
157NANOG_16153702_ChIP-ChIP_HESCs_Human0.74239058

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.01583935
2MP0003693_abnormal_embryo_hatching3.81146025
3MP0004147_increased_porphyrin_level3.70413780
4MP0005058_abnormal_lysosome_morphology3.46706634
5MP0004957_abnormal_blastocyst_morpholog3.32611575
6MP0010094_abnormal_chromosome_stability3.21392134
7MP0003111_abnormal_nucleus_morphology3.02918610
8MP0008057_abnormal_DNA_replication2.93536831
9MP0009840_abnormal_foam_cell2.93000942
10MP0003191_abnormal_cellular_cholesterol2.80342749
11MP0003077_abnormal_cell_cycle2.78747888
12MP0009278_abnormal_bone_marrow2.73816955
13MP0008007_abnormal_cellular_replicative2.71245613
14MP0005451_abnormal_body_composition2.69176737
15MP0009697_abnormal_copulation2.65729229
16MP0008058_abnormal_DNA_repair2.59515518
17MP0003279_aneurysm2.40164729
18MP0009379_abnormal_foot_pigmentation2.33681930
19MP0002132_abnormal_respiratory_system2.31530865
20MP0002396_abnormal_hematopoietic_system2.30150548
21MP0003705_abnormal_hypodermis_morpholog2.13242418
22MP0005464_abnormal_platelet_physiology2.10719528
23MP0005075_abnormal_melanosome_morpholog2.07352532
24MP0003806_abnormal_nucleotide_metabolis2.03397832
25MP0003123_paternal_imprinting1.99954136
26MP0010030_abnormal_orbit_morphology1.98698327
27MP0001835_abnormal_antigen_presentation1.96237887
28MP0002102_abnormal_ear_morphology1.92417565
29MP0008932_abnormal_embryonic_tissue1.86329684
30MP0003786_premature_aging1.85529660
31MP0002163_abnormal_gland_morphology1.80488166
32MP0005671_abnormal_response_to1.78834780
33MP0001542_abnormal_bone_strength1.77448949
34MP0009333_abnormal_splenocyte_physiolog1.76946942
35MP0000490_abnormal_crypts_of1.76033669
36MP0000465_gastrointestinal_hemorrhage1.71643939
37MP0008877_abnormal_DNA_methylation1.70278776
38MP0002877_abnormal_melanocyte_morpholog1.70027178
39MP0003121_genomic_imprinting1.69885698
40MP0000750_abnormal_muscle_regeneration1.69181562
41MP0003122_maternal_imprinting1.68559001
42MP0006292_abnormal_olfactory_placode1.61031018
43MP0008260_abnormal_autophagy1.59851057
44MP0004858_abnormal_nervous_system1.58282367
45MP0005025_abnormal_response_to1.57496319
46MP0002398_abnormal_bone_marrow1.56078554
47MP0000681_abnormal_thyroid_gland1.54617658
48MP0002419_abnormal_innate_immunity1.53248399
49MP0003172_abnormal_lysosome_physiology1.51750210
50MP0001958_emphysema1.49849949
51MP0001188_hyperpigmentation1.48726394
52MP0005408_hypopigmentation1.48620602
53MP0009384_cardiac_valve_regurgitation1.45713491
54MP0001533_abnormal_skeleton_physiology1.44680828
55MP0001293_anophthalmia1.44625963
56MP0006036_abnormal_mitochondrial_physio1.43171571
57MP0010368_abnormal_lymphatic_system1.37394520
58MP0000751_myopathy1.37057935
59MP0003186_abnormal_redox_activity1.36598560
60MP0002938_white_spotting1.35942317
61MP0004272_abnormal_basement_membrane1.35668786
62MP0005257_abnormal_intraocular_pressure1.33872506
63MP0005174_abnormal_tail_pigmentation1.33375888
64MP0005084_abnormal_gallbladder_morpholo1.32861176
65MP0003303_peritoneal_inflammation1.32656873
66MP0006035_abnormal_mitochondrial_morpho1.30496826
67MP0000343_altered_response_to1.29583835
68MP0003075_altered_response_to1.29347488
69MP0001529_abnormal_vocalization1.28862455
70MP0005390_skeleton_phenotype1.28810983
71MP0001873_stomach_inflammation1.28256243
72MP0000689_abnormal_spleen_morphology1.26700586
73MP0002722_abnormal_immune_system1.26394348
74MP0003763_abnormal_thymus_physiology1.26020646
75MP0000350_abnormal_cell_proliferation1.24840776
76MP0000703_abnormal_thymus_morphology1.21875864
77MP0005165_increased_susceptibility_to1.21652932
78MP0001661_extended_life_span1.21389662
79MP0002160_abnormal_reproductive_system1.20325093
80* MP0002019_abnormal_tumor_incidence1.20089779
81* MP0002429_abnormal_blood_cell1.19719282
82MP0009785_altered_susceptibility_to1.18581956
83* MP0000313_abnormal_cell_death1.17150929
84MP0000858_altered_metastatic_potential1.16110973
85MP0005330_cardiomyopathy1.14782050
86MP0006054_spinal_hemorrhage1.13713414
87MP0004808_abnormal_hematopoietic_stem1.12913825
88MP0003718_maternal_effect1.12726087
89MP0000015_abnormal_ear_pigmentation1.12718673
90MP0005501_abnormal_skin_physiology1.11259117
91MP0005360_urolithiasis1.10878637
92MP0003566_abnormal_cell_adhesion1.10755803
93MP0002095_abnormal_skin_pigmentation1.10223849
94MP0005379_endocrine/exocrine_gland_phen1.09255814
95MP0001730_embryonic_growth_arrest1.08669383
96* MP0000716_abnormal_immune_system1.07943634
97MP0001800_abnormal_humoral_immune1.07824291
98MP0005508_abnormal_skeleton_morphology1.05692331
99MP0005275_abnormal_skin_tensile1.05576951
100MP0002060_abnormal_skin_morphology1.03520248
101MP0002998_abnormal_bone_remodeling1.02591076
102MP0002933_joint_inflammation1.02417784
103MP0005503_abnormal_tendon_morphology1.00379386
104MP0003656_abnormal_erythrocyte_physiolo0.99531900
105MP0008469_abnormal_protein_level0.98992651
106MP0000678_abnormal_parathyroid_gland0.97615486
107MP0002420_abnormal_adaptive_immunity0.97362606
108MP0001819_abnormal_immune_cell0.97143115
109MP0005397_hematopoietic_system_phenotyp0.96530681
110MP0001545_abnormal_hematopoietic_system0.96530681
111MP0001845_abnormal_inflammatory_respons0.95636003
112MP0002210_abnormal_sex_determination0.94841413
113MP0002080_prenatal_lethality0.94744920
114MP0005670_abnormal_white_adipose0.94021749
115MP0001346_abnormal_lacrimal_gland0.93834039
116MP0002452_abnormal_antigen_presenting0.93498522
117MP0000003_abnormal_adipose_tissue0.92882476
118MP0002638_abnormal_pupillary_reflex0.91457128
119MP0001881_abnormal_mammary_gland0.91400371
120MP0000759_abnormal_skeletal_muscle0.90977040
121MP0001186_pigmentation_phenotype0.90669110
122MP0001145_abnormal_male_reproductive0.89160312
123MP0003119_abnormal_digestive_system0.88370774
124MP0010155_abnormal_intestine_physiology0.87211720
125MP0005387_immune_system_phenotype0.86492175
126MP0001790_abnormal_immune_system0.86492175
127MP0005023_abnormal_wound_healing0.85649289
128MP0000358_abnormal_cell_content/0.85637080
129MP0009764_decreased_sensitivity_to0.85243786
130MP0003787_abnormal_imprinting0.84960502
131MP0005389_reproductive_system_phenotype0.84939020
132MP0001853_heart_inflammation0.84557517
133MP0003795_abnormal_bone_structure0.84459576
134MP0009053_abnormal_anal_canal0.84436953
135MP0003567_abnormal_fetal_cardiomyocyte0.83515253
136MP0004947_skin_inflammation0.83203050
137MP0000685_abnormal_immune_system0.83098247
138MP0000747_muscle_weakness0.82704742
139MP0004510_myositis0.82092916
140MP0005220_abnormal_exocrine_pancreas0.81914029
141MP0002723_abnormal_immune_serum0.81055330
142MP0006082_CNS_inflammation0.80609532
143MP0005584_abnormal_enzyme/coenzyme_acti0.80493621
144MP0002405_respiratory_system_inflammati0.79925834
145MP0001697_abnormal_embryo_size0.79909558
146MP0002282_abnormal_trachea_morphology0.79381370
147MP0001672_abnormal_embryogenesis/_devel0.78639274
148MP0005380_embryogenesis_phenotype0.78639274
149MP0003315_abnormal_perineum_morphology0.78213837
150MP0000477_abnormal_intestine_morphology0.77352622
151MP0003448_altered_tumor_morphology0.77129501
152MP0003436_decreased_susceptibility_to0.76674066
153MP0000767_abnormal_smooth_muscle0.75276674
154MP0002751_abnormal_autonomic_nervous0.74579999
155* MP0005000_abnormal_immune_tolerance0.74461238
156MP0002148_abnormal_hypersensitivity_rea0.74339066
157MP0008789_abnormal_olfactory_epithelium0.73443501
158MP0001243_abnormal_dermal_layer0.72779607
159MP0001929_abnormal_gametogenesis0.72178202
160MP0000049_abnormal_middle_ear0.71834784
161MP0000653_abnormal_sex_gland0.71035656
162MP0001919_abnormal_reproductive_system0.70594552

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.84673878
2Abnormal number of erythroid precursors (HP:0012131)5.46360081
3Birth length less than 3rd percentile (HP:0003561)5.04829030
4Abnormality of the heme biosynthetic pathway (HP:0010472)5.00064390
5Reticulocytopenia (HP:0001896)4.65656044
6Macrocytic anemia (HP:0001972)4.20929907
7Increased hepatocellular lipid droplets (HP:0006565)3.96968967
8Pallor (HP:0000980)3.88878925
9Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.74563012
10Protrusio acetabuli (HP:0003179)3.73716376
11Premature rupture of membranes (HP:0001788)3.71820572
12Lipid accumulation in hepatocytes (HP:0006561)3.67316560
13Renal Fanconi syndrome (HP:0001994)3.55406436
14Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.53419574
15Aplastic anemia (HP:0001915)3.47797970
16Respiratory difficulties (HP:0002880)3.44746208
17Abnormality of glycolipid metabolism (HP:0010969)3.42161208
18Abnormality of liposaccharide metabolism (HP:0010968)3.42161208
19Abnormality of glycosphingolipid metabolism (HP:0004343)3.42161208
20Oral leukoplakia (HP:0002745)3.35915009
21Decreased activity of mitochondrial respiratory chain (HP:0008972)3.20124100
22Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.20124100
23Exertional dyspnea (HP:0002875)3.10929737
24Mitochondrial inheritance (HP:0001427)3.08177559
25Acute necrotizing encephalopathy (HP:0006965)3.06090969
2611 pairs of ribs (HP:0000878)3.05038030
27Breast hypoplasia (HP:0003187)2.98311903
28Dysostosis multiplex (HP:0000943)2.93214367
29Increased CSF lactate (HP:0002490)2.89555483
30Petechiae (HP:0000967)2.85845802
31IgM deficiency (HP:0002850)2.80118839
32Hypertensive crisis (HP:0100735)2.75542345
33Abnormal mitochondria in muscle tissue (HP:0008316)2.73801113
34Increased serum lactate (HP:0002151)2.72460300
353-Methylglutaconic aciduria (HP:0003535)2.67535831
36Joint stiffness (HP:0001387)2.63993705
37Achilles tendon contracture (HP:0001771)2.62862739
38Chronic obstructive pulmonary disease (HP:0006510)2.60269869
39Obstructive lung disease (HP:0006536)2.60269869
40Type I transferrin isoform profile (HP:0003642)2.59713999
41J-shaped sella turcica (HP:0002680)2.56169277
42Hepatocellular necrosis (HP:0001404)2.50612511
43Distal lower limb muscle weakness (HP:0009053)2.50141604
44Vacuolated lymphocytes (HP:0001922)2.46718708
45Abnormal lung lobation (HP:0002101)2.45912546
46Cholecystitis (HP:0001082)2.43407300
47Abnormal gallbladder physiology (HP:0012438)2.43407300
48Patellar aplasia (HP:0006443)2.43035389
49Abnormal number of incisors (HP:0011064)2.41757923
50Premature graying of hair (HP:0002216)2.41743300
51Microvesicular hepatic steatosis (HP:0001414)2.40687752
52Acute encephalopathy (HP:0006846)2.39785921
53Abnormality of the umbilical cord (HP:0010881)2.39780547
54Generalized amyotrophy (HP:0003700)2.39039734
55Agammaglobulinemia (HP:0004432)2.37073494
56Aplasia/Hypoplasia of the patella (HP:0006498)2.36187689
57Entropion (HP:0000621)2.33030021
58Cervical subluxation (HP:0003308)2.32917462
59Hepatosplenomegaly (HP:0001433)2.31574531
60Increased intramyocellular lipid droplets (HP:0012240)2.30972094
61Abnormality of mucopolysaccharide metabolism (HP:0011020)2.28604086
62Abnormality of polysaccharide metabolism (HP:0011012)2.28604086
63Abnormality of glycosaminoglycan metabolism (HP:0004371)2.28604086
64Rough bone trabeculation (HP:0100670)2.27628656
65Pancytopenia (HP:0001876)2.26558398
66Abnormality of the Achilles tendon (HP:0005109)2.26429997
67Cellulitis (HP:0100658)2.25624153
68IgG deficiency (HP:0004315)2.24797810
69Distal upper limb amyotrophy (HP:0007149)2.23375454
70Upper limb amyotrophy (HP:0009129)2.23375454
71Elbow flexion contracture (HP:0002987)2.22839774
72Recurrent bronchitis (HP:0002837)2.22311586
73Trismus (HP:0000211)2.20431841
74Hepatic necrosis (HP:0002605)2.17747004
75Absent thumb (HP:0009777)2.17590731
76Progressive macrocephaly (HP:0004481)2.15337354
77Centrally nucleated skeletal muscle fibers (HP:0003687)2.14259635
78Abnormality of renal resorption (HP:0011038)2.13867304
79Lactic acidosis (HP:0003128)2.13189656
80Bulbar palsy (HP:0001283)2.12524292
81Facial cleft (HP:0002006)2.11042492
82Stridor (HP:0010307)2.10532780
83Abnormality of skeletal muscle fiber size (HP:0012084)2.10283315
84Prolonged neonatal jaundice (HP:0006579)2.10099715
85Elevated erythrocyte sedimentation rate (HP:0003565)2.09354352
86Exercise intolerance (HP:0003546)2.09299754
87Mucopolysacchariduria (HP:0008155)2.09213693
88Urinary glycosaminoglycan excretion (HP:0003541)2.09213693
89Ragged-red muscle fibers (HP:0003200)2.08172351
90Rhabdomyolysis (HP:0003201)2.06720409
91Myopathic facies (HP:0002058)2.06698795
92Biconcave vertebral bodies (HP:0004586)2.06250079
93Pulmonary fibrosis (HP:0002206)2.05755214
94Redundant skin (HP:0001582)2.04785699
95Reduced antithrombin III activity (HP:0001976)2.04384919
96Abnormality of reticulocytes (HP:0004312)2.04257162
97Increased variability in muscle fiber diameter (HP:0003557)2.04022477
98Asplenia (HP:0001746)2.02381224
99Type 1 muscle fiber predominance (HP:0003803)2.01626467
100Hyperphosphaturia (HP:0003109)2.00735451
101Ankle contracture (HP:0006466)2.00365216
102Purpura (HP:0000979)1.97889021
103Testicular atrophy (HP:0000029)1.97246682
104Hand muscle atrophy (HP:0009130)1.97151956
105Progressive muscle weakness (HP:0003323)1.96403564
106Slender long bone (HP:0003100)1.96221934
107Degeneration of anterior horn cells (HP:0002398)1.95645729
108Abnormality of the anterior horn cell (HP:0006802)1.95645729
109Increased neuronal autofluorescent lipopigment (HP:0002074)1.94234940
110Triphalangeal thumb (HP:0001199)1.93738565
111Blue sclerae (HP:0000592)1.93419423
112Increased cerebral lipofuscin (HP:0011813)1.92503652
113Depressed nasal ridge (HP:0000457)1.90988082
114Thrombocytosis (HP:0001894)1.90574445
115Abnormality of T cell physiology (HP:0011840)1.89907751
116Increased muscle lipid content (HP:0009058)1.89291300
117Vertebral compression fractures (HP:0002953)1.88871736
118Spinal rigidity (HP:0003306)1.88250686
119Cerebral palsy (HP:0100021)1.86767091
120Increased connective tissue (HP:0009025)1.85196510
121Premature skin wrinkling (HP:0100678)1.85055755
122Multiple enchondromatosis (HP:0005701)1.84895216
123Abnormal protein glycosylation (HP:0012346)1.84398048
124Abnormal glycosylation (HP:0012345)1.84398048
125Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.84398048
126Abnormal protein N-linked glycosylation (HP:0012347)1.84398048
127Optic nerve coloboma (HP:0000588)1.84337901
128Esophageal neoplasm (HP:0100751)1.83350641
129Neoplasm of head and neck (HP:0012288)1.83350641
130Mildly elevated creatine phosphokinase (HP:0008180)1.82812606
131Horseshoe kidney (HP:0000085)1.82748041
132Bladder diverticulum (HP:0000015)1.82318675
133Supernumerary spleens (HP:0009799)1.81700138
134Fragile skin (HP:0001030)1.81651780
135Selective tooth agenesis (HP:0001592)1.80813111
136Abnormal trabecular bone morphology (HP:0100671)1.79750699
137Poor head control (HP:0002421)1.79199475
138Aplasia/Hypoplasia of the sacrum (HP:0008517)1.78997118
139Bone marrow hypocellularity (HP:0005528)1.78838534
140Congenital, generalized hypertrichosis (HP:0004540)1.78666337
141Single umbilical artery (HP:0001195)1.77623794
142Abnormality of the fetal cardiovascular system (HP:0010948)1.77623794
143Abnormal umbilical cord blood vessels (HP:0011403)1.77623794
144Aplasia/Hypoplasia of the spleen (HP:0010451)1.77013147
145Spondylolisthesis (HP:0003302)1.76942674
146Thin bony cortex (HP:0002753)1.76818500
147Mediastinal lymphadenopathy (HP:0100721)1.76632822
148Carpal bone hypoplasia (HP:0001498)1.75252737
149Hyperacusis (HP:0010780)1.75041960
150Nonimmune hydrops fetalis (HP:0001790)1.73863735
151Abnormality of the tricuspid valve (HP:0001702)1.73860125
152Secondary amenorrhea (HP:0000869)1.73184516
153Lymphoma (HP:0002665)1.72522748
154Hypochromic anemia (HP:0001931)1.71913071
155Sparse eyelashes (HP:0000653)1.71828259
156Easy fatigability (HP:0003388)1.71636194
157Abnormality of the distal phalanges of the toes (HP:0010182)1.71045706
158Abnormality of dicarboxylic acid metabolism (HP:0010995)1.70461929
159Dicarboxylic aciduria (HP:0003215)1.70461929
160Pancreatic fibrosis (HP:0100732)1.70256869
161Muscle stiffness (HP:0003552)1.69050494
162Recurrent sinusitis (HP:0011108)1.68936094
163Microretrognathia (HP:0000308)1.68403445
164Hypertriglyceridemia (HP:0002155)1.68144852
165Fatigue (HP:0012378)1.66967944
166Wormian bones (HP:0002645)1.66755321
167Opisthotonus (HP:0002179)1.66084336
168Tongue fasciculations (HP:0001308)1.65882554
169Neutropenia (HP:0001875)1.65574775
170Cerebral edema (HP:0002181)1.64960189
171Abnormal spermatogenesis (HP:0008669)1.64945096
172Cellular immunodeficiency (HP:0005374)1.64923906
173Pancreatic cysts (HP:0001737)1.62728483
174Glycosuria (HP:0003076)1.62419275
175Abnormality of urine glucose concentration (HP:0011016)1.62419275
176Meckel diverticulum (HP:0002245)1.62200519
177Abnormal hair whorl (HP:0010721)1.62065880

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.95787051
2BRD43.92469223
3TLK13.34293381
4ERN13.18007118
5NME23.13049680
6EIF2AK12.90391492
7PIM22.70202172
8TRIB32.63879947
9STK162.61818076
10SCYL22.57679041
11VRK22.48791747
12WEE12.45215158
13ACVR1B2.34860406
14CDC72.27021053
15PLK42.25386450
16SRPK12.20245617
17VRK12.10973946
18MUSK2.04151994
19ARAF1.96966581
20TBK11.93622778
21LIMK11.92091972
22NME11.87785792
23MKNK21.77386086
24MKNK11.75709631
25MAP3K121.70723467
26IRAK41.69041204
27ABL21.56674333
28MAPKAPK31.55754755
29PRPF4B1.52118706
30TIE11.50783570
31PLK11.49476786
32BRSK21.45216419
33BRSK11.40762244
34BRAF1.27642674
35SMG11.26755924
36MAP3K111.26600728
37SIK11.22023932
38PLK31.20748132
39CCNB11.20405405
40TEC1.20149192
41BCKDK1.18664308
42CDK81.18448546
43TGFBR11.18219419
44CDK71.16401951
45ILK1.15756288
46MAP3K141.14260137
47DYRK31.09926386
48RPS6KB21.08012835
49DYRK21.06159746
50MAP2K21.03424116
51MAP4K11.02933404
52EIF2AK31.02528734
53ATR1.02166460
54AURKB1.00380383
55NEK20.99640160
56PAK40.99202315
57AURKA0.96092832
58PKN20.95016289
59TTN0.94782024
60DAPK10.94267673
61TYK20.94125474
62PASK0.93429531
63PRKD20.92922970
64CDK190.92594455
65EIF2AK20.91687376
66FLT30.90904278
67DAPK30.90503987
68EEF2K0.90369335
69JAK30.90063193
70CASK0.89726896
71EPHA20.88515438
72PIM10.86766695
73ZAK0.84546235
74TTK0.83148178
75PRKCI0.83013745
76ZAP700.82370607
77IKBKB0.81669175
78TESK20.81496624
79TAOK20.79359138
80TSSK60.78048975
81KDR0.77771554
82TESK10.75750035
83SYK0.75687969
84MAP3K130.75059423
85IKBKE0.72561361
86FES0.72559309
87BTK0.71840329
88CSNK2A10.71791270
89LRRK20.71399107
90PLK20.69198081
91BMPR20.68572409
92BMPR1B0.68175148
93RPS6KA20.67307642
94MAP2K30.64527407
95LMTK20.64431387
96GRK60.64125021
97KIT0.62441724
98MOS0.60755482
99RPS6KA40.60133227
100NEK90.60004042
101RPS6KL10.59698612
102RPS6KC10.59698612
103MAPK110.58782287
104IRAK30.57395777
105FRK0.57126921
106PAK10.55601630
107TGFBR20.54929943
108CLK10.54831804
109CSNK2A20.54638382
110DDR20.54102454
111MAP3K30.53804999
112PDPK10.53680339
113CDK120.52564901
114RAF10.52475629
115CHEK20.52222887
116MAP4K20.51395307
117RPS6KA50.51037002
118BLK0.48340706
119MAP3K80.48121626
120NLK0.47464942
121ERBB30.46951809
122CHEK10.46382624
123CSF1R0.46164923
124LYN0.45722821
125PAK20.45561990
126SIK30.45423231
127CDK40.45213313
128PTK20.44524948
129STK100.43908024
130MAPKAPK20.43803847
131STK38L0.43331028
132TXK0.42600440
133RPS6KA60.42505955
134MAPK120.42253546
135TNK20.42241817
136MAP2K60.42153439
137YES10.41898836
138PRKD10.41840764
139MST40.39434479
140PIK3CG0.38358758
141CAMK2G0.38316113
142MAPK40.37486530
143MYLK0.37226284
144PRKG20.36306847
145MATK0.35643573
146MAP3K10.35404020
147ATM0.35008130
148AKT20.34145632
149RIPK40.33623718
150DYRK1B0.33608199
151PRKCD0.33495017
152MAP3K60.33397699
153EPHB20.31498086
154CSNK1G30.30452733
155PBK0.29486061

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.13658373
2Proteasome_Homo sapiens_hsa030504.50838554
3RNA polymerase_Homo sapiens_hsa030203.96088939
4DNA replication_Homo sapiens_hsa030303.76827875
5Other glycan degradation_Homo sapiens_hsa005113.49290843
6Mismatch repair_Homo sapiens_hsa034303.28416398
7Glycosaminoglycan degradation_Homo sapiens_hsa005312.82556517
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.80547899
9Spliceosome_Homo sapiens_hsa030402.79650643
10Pyrimidine metabolism_Homo sapiens_hsa002402.58784553
11* Base excision repair_Homo sapiens_hsa034102.55628466
12Protein export_Homo sapiens_hsa030602.46677296
13Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.38613440
14Nucleotide excision repair_Homo sapiens_hsa034202.32035791
15Homologous recombination_Homo sapiens_hsa034402.29308089
16RNA transport_Homo sapiens_hsa030132.21878832
17Basal transcription factors_Homo sapiens_hsa030222.06336515
18One carbon pool by folate_Homo sapiens_hsa006702.01935167
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.00752215
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.95603150
21Oxidative phosphorylation_Homo sapiens_hsa001901.87950362
22Asthma_Homo sapiens_hsa053101.84045449
23Non-homologous end-joining_Homo sapiens_hsa034501.73567266
24Parkinsons disease_Homo sapiens_hsa050121.72910839
25Lysosome_Homo sapiens_hsa041421.68963189
26Cell cycle_Homo sapiens_hsa041101.67858056
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.62139164
28Huntingtons disease_Homo sapiens_hsa050161.52773354
29Sulfur relay system_Homo sapiens_hsa041221.52650310
30Fatty acid elongation_Homo sapiens_hsa000621.50137775
31RNA degradation_Homo sapiens_hsa030181.48164446
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.45509346
33Shigellosis_Homo sapiens_hsa051311.43916429
34Fanconi anemia pathway_Homo sapiens_hsa034601.40849501
35Sulfur metabolism_Homo sapiens_hsa009201.38767508
36p53 signaling pathway_Homo sapiens_hsa041151.34827209
37Caffeine metabolism_Homo sapiens_hsa002321.33838353
38Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.31735265
39Purine metabolism_Homo sapiens_hsa002301.31272859
40Leishmaniasis_Homo sapiens_hsa051401.27495068
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.26767755
42Drug metabolism - other enzymes_Homo sapiens_hsa009831.14329451
43Folate biosynthesis_Homo sapiens_hsa007901.14111469
44Primary immunodeficiency_Homo sapiens_hsa053401.10781822
45Rheumatoid arthritis_Homo sapiens_hsa053231.05898046
46Epstein-Barr virus infection_Homo sapiens_hsa051691.05823130
47Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.05291826
48Acute myeloid leukemia_Homo sapiens_hsa052211.01167341
49Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.00982517
50Alzheimers disease_Homo sapiens_hsa050101.00413412
51mRNA surveillance pathway_Homo sapiens_hsa030150.97167920
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.93464101
53Systemic lupus erythematosus_Homo sapiens_hsa053220.91934883
54Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.90192128
55Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.89157311
56Salmonella infection_Homo sapiens_hsa051320.86606314
57Herpes simplex infection_Homo sapiens_hsa051680.85206026
58Antigen processing and presentation_Homo sapiens_hsa046120.83738334
59Allograft rejection_Homo sapiens_hsa053300.81442650
60Tuberculosis_Homo sapiens_hsa051520.78082512
61Intestinal immune network for IgA production_Homo sapiens_hsa046720.77260250
62Graft-versus-host disease_Homo sapiens_hsa053320.72100671
63Toxoplasmosis_Homo sapiens_hsa051450.71369295
64Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69846377
65Staphylococcus aureus infection_Homo sapiens_hsa051500.68024821
66Cyanoamino acid metabolism_Homo sapiens_hsa004600.66594803
67Toll-like receptor signaling pathway_Homo sapiens_hsa046200.64911501
68Phagosome_Homo sapiens_hsa041450.64830345
69Central carbon metabolism in cancer_Homo sapiens_hsa052300.64543192
70Endocytosis_Homo sapiens_hsa041440.63907663
71Arachidonic acid metabolism_Homo sapiens_hsa005900.62838769
72Pertussis_Homo sapiens_hsa051330.61184738
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60760041
74Type I diabetes mellitus_Homo sapiens_hsa049400.59757075
75Glutathione metabolism_Homo sapiens_hsa004800.59457015
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58398044
77Pentose phosphate pathway_Homo sapiens_hsa000300.57927818
78Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.57499688
79N-Glycan biosynthesis_Homo sapiens_hsa005100.57042286
80Phenylalanine metabolism_Homo sapiens_hsa003600.55884811
81Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.55475198
82Legionellosis_Homo sapiens_hsa051340.53476619
83Malaria_Homo sapiens_hsa051440.52906266
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52025125
85B cell receptor signaling pathway_Homo sapiens_hsa046620.51199205
86Measles_Homo sapiens_hsa051620.51198152
87Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.50830589
88Galactose metabolism_Homo sapiens_hsa000520.50143622
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49341116
90Osteoclast differentiation_Homo sapiens_hsa043800.49134083
91Tyrosine metabolism_Homo sapiens_hsa003500.48028701
92Selenocompound metabolism_Homo sapiens_hsa004500.47694014
93SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46791519
94Cysteine and methionine metabolism_Homo sapiens_hsa002700.46494915
95Linoleic acid metabolism_Homo sapiens_hsa005910.46430960
96Metabolic pathways_Homo sapiens_hsa011000.45589935
97Peroxisome_Homo sapiens_hsa041460.44927837
98Viral carcinogenesis_Homo sapiens_hsa052030.44275821
99Thyroid cancer_Homo sapiens_hsa052160.42957684
100VEGF signaling pathway_Homo sapiens_hsa043700.41549141
101Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.40880097
102Autoimmune thyroid disease_Homo sapiens_hsa053200.40745450
103HTLV-I infection_Homo sapiens_hsa051660.40051699
104Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38353965
105Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37993695
106Oocyte meiosis_Homo sapiens_hsa041140.34327568
107Vibrio cholerae infection_Homo sapiens_hsa051100.33283567
108Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.33281439
109Apoptosis_Homo sapiens_hsa042100.29403898
110NF-kappa B signaling pathway_Homo sapiens_hsa040640.28734044
111Hematopoietic cell lineage_Homo sapiens_hsa046400.28114874
112Transcriptional misregulation in cancer_Homo sapiens_hsa052020.27490072
113RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.27403721
114Hepatitis B_Homo sapiens_hsa051610.27393934
115Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.26893934
116Small cell lung cancer_Homo sapiens_hsa052220.26415877
117Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.26333066
118Vitamin B6 metabolism_Homo sapiens_hsa007500.25760616
119Influenza A_Homo sapiens_hsa051640.25193853
120Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.24275069
121Alcoholism_Homo sapiens_hsa050340.23479620
122alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.22902815
123Biosynthesis of amino acids_Homo sapiens_hsa012300.22852801
124Bladder cancer_Homo sapiens_hsa052190.21569613
125Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.21452932
126Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.21312926
127Fructose and mannose metabolism_Homo sapiens_hsa000510.17638078
128Pyruvate metabolism_Homo sapiens_hsa006200.17404520
129Chemical carcinogenesis_Homo sapiens_hsa052040.16895298
130Viral myocarditis_Homo sapiens_hsa054160.15251555
131Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.14978353
132Vitamin digestion and absorption_Homo sapiens_hsa049770.11648252
133Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.11530162
134Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.09614243
135Carbon metabolism_Homo sapiens_hsa012000.09603136
136Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.09428133

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