MPEG1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of immune response of other organism involved in symbiotic interaction (GO:008.43731016
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:08.43731016
3positive regulation by organism of defense response of other organism involved in symbiotic interact8.43731016
4modulation by symbiont of host immune response (GO:0052553)8.43731016
5positive regulation by symbiont of host defense response (GO:0052509)8.43731016
6modulation by symbiont of host defense response (GO:0052031)8.43731016
7regulation of interferon-beta biosynthetic process (GO:0045357)7.12342486
8macrophage activation involved in immune response (GO:0002281)6.08297665
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.03594644
10positive regulation of interleukin-8 biosynthetic process (GO:0045416)5.69562766
11microglial cell activation (GO:0001774)5.54497555
12positive regulation of interferon-alpha production (GO:0032727)5.49687357
13response to immune response of other organism involved in symbiotic interaction (GO:0052564)5.48422811
14response to host immune response (GO:0052572)5.48422811
15regulation of interferon-alpha production (GO:0032647)5.21127817
16detection of other organism (GO:0098543)5.18273327
17response to host (GO:0075136)4.98110092
18response to host defenses (GO:0052200)4.98110092
19response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.98110092
20neutrophil activation involved in immune response (GO:0002283)4.96022548
21detection of bacterium (GO:0016045)4.78066492
22immunoglobulin mediated immune response (GO:0016064)4.55876713
23regulation of gamma-delta T cell activation (GO:0046643)4.48280087
24detection of external biotic stimulus (GO:0098581)4.42637950
25macrophage activation (GO:0042116)4.36236056
26response to peptidoglycan (GO:0032494)4.31381325
27respiratory burst (GO:0045730)4.23591802
28positive regulation of antigen processing and presentation (GO:0002579)4.07610408
29regulation of B cell receptor signaling pathway (GO:0050855)4.05936377
30detection of biotic stimulus (GO:0009595)4.00026931
31regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.94029053
32regulation of interleukin-8 biosynthetic process (GO:0045414)3.90946286
33myeloid cell activation involved in immune response (GO:0002275)3.85727707
34I-kappaB phosphorylation (GO:0007252)3.81653072
35positive regulation of interferon-beta production (GO:0032728)3.80606905
36positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.75770819
37negative regulation of lymphocyte mediated immunity (GO:0002707)3.75354826
38positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.75236026
39negative regulation of T cell mediated immunity (GO:0002710)3.74104573
40regulation of gamma-delta T cell differentiation (GO:0045586)3.66012491
41leukocyte aggregation (GO:0070486)3.65075314
42negative regulation of erythrocyte differentiation (GO:0045647)3.59965550
43regulation of tolerance induction (GO:0002643)3.59859458
44regulation of T cell tolerance induction (GO:0002664)3.58374137
45antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.49980142
46antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.49980142
47positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.48754524
48granulocyte activation (GO:0036230)3.48053705
49antigen processing and presentation via MHC class Ib (GO:0002475)3.44497377
50pinocytosis (GO:0006907)3.42059846
51neutrophil activation (GO:0042119)3.41700476
52positive regulation of mast cell activation (GO:0033005)3.41224050
53negative regulation of leukocyte mediated immunity (GO:0002704)3.40778983
54regulation of mononuclear cell migration (GO:0071675)3.39579884
55regulation of antigen processing and presentation (GO:0002577)3.38467224
56positive regulation of gamma-delta T cell activation (GO:0046645)3.35006125
57antigen processing and presentation of endogenous antigen (GO:0019883)3.34611581
58regulation of cholesterol storage (GO:0010885)3.31566609
59regulation of mast cell degranulation (GO:0043304)3.30835916
60B cell receptor signaling pathway (GO:0050853)3.25151655
61positive regulation of cellular amide metabolic process (GO:0034250)3.24776173
62regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.24388672
63lipopolysaccharide-mediated signaling pathway (GO:0031663)3.24286932
64B cell mediated immunity (GO:0019724)3.18579840
65positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.16169225
66positive thymic T cell selection (GO:0045059)3.15085538
67positive regulation of B cell differentiation (GO:0045579)3.14817848
68T cell migration (GO:0072678)3.13975227
69negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.10909432
70negative regulation of cell killing (GO:0031342)3.10909432
71regulation of mast cell activation involved in immune response (GO:0033006)3.10864949
72hydrogen peroxide biosynthetic process (GO:0050665)3.10377216
73response to muramyl dipeptide (GO:0032495)3.10084652
74regulation of mast cell activation (GO:0033003)3.08207935
75neutrophil mediated immunity (GO:0002446)3.07731075
76positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.06871906
77positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.06138772
78regulation of B cell differentiation (GO:0045577)3.04154737
79positive regulation of leukocyte degranulation (GO:0043302)3.03535607
80regulation of leukocyte degranulation (GO:0043300)3.03290141
81detection of molecule of bacterial origin (GO:0032490)3.02810618
82cellular response to thyroid hormone stimulus (GO:0097067)3.02728862
83positive regulation of tolerance induction (GO:0002645)3.02655571
84positive regulation of toll-like receptor signaling pathway (GO:0034123)3.02046001
85apoptotic cell clearance (GO:0043277)3.01975152
86T-helper 1 type immune response (GO:0042088)3.01463883
87positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.00952169
88low-density lipoprotein particle clearance (GO:0034383)3.00900687
89negative regulation of interleukin-17 production (GO:0032700)3.00604730
90negative thymic T cell selection (GO:0045060)3.00233619
91regulation of dendritic cell antigen processing and presentation (GO:0002604)2.98780203
92mannose metabolic process (GO:0006013)2.98724804
93regulation of regulated secretory pathway (GO:1903305)2.98646748
94cellular extravasation (GO:0045123)2.98564572
95regulation of interferon-gamma biosynthetic process (GO:0045072)2.98238988
96myeloid leukocyte mediated immunity (GO:0002444)2.97648343
97positive regulation of type 2 immune response (GO:0002830)2.94332064
98regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.93955949
99production of molecular mediator involved in inflammatory response (GO:0002532)2.93077428
100positive regulation of mast cell activation involved in immune response (GO:0033008)2.92954369
101positive regulation of mast cell degranulation (GO:0043306)2.92954369
102negative regulation of mast cell activation (GO:0033004)2.91480420
103positive regulation of chemokine biosynthetic process (GO:0045080)2.90646678
104activated T cell proliferation (GO:0050798)2.90030013
105negative T cell selection (GO:0043383)2.89750424
106leukocyte migration involved in inflammatory response (GO:0002523)2.89135444
107T cell selection (GO:0045058)2.87169537
108dendritic cell migration (GO:0036336)2.85739401
109myeloid leukocyte activation (GO:0002274)2.84962493
110germinal center formation (GO:0002467)2.84442050
111regulation of interferon-beta production (GO:0032648)2.84353620
112regulation of T-helper 2 cell differentiation (GO:0045628)2.83703767
113dendritic cell chemotaxis (GO:0002407)2.82947984
114natural killer cell mediated cytotoxicity (GO:0042267)2.81342624
115natural killer cell mediated immunity (GO:0002228)2.81342624
116interferon-gamma-mediated signaling pathway (GO:0060333)2.76849961
117regulation of myeloid leukocyte mediated immunity (GO:0002886)2.76069156
118type I interferon signaling pathway (GO:0060337)2.75478612
119cellular response to type I interferon (GO:0071357)2.75478612
120response to type I interferon (GO:0034340)2.74509625
121negative regulation of interleukin-6 production (GO:0032715)2.73108763
122reactive oxygen species biosynthetic process (GO:1903409)2.72538339
123negative regulation of interleukin-12 production (GO:0032695)2.69970105
124positive regulation of chemokine production (GO:0032722)2.69401663
125positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.66766725
126hyaluronan catabolic process (GO:0030214)2.65370516
127negative regulation of granulocyte differentiation (GO:0030853)2.63458610
128neutrophil chemotaxis (GO:0030593)2.61665527
129glycosphingolipid catabolic process (GO:0046479)2.61663798
130superoxide anion generation (GO:0042554)2.57876308
131modification by symbiont of host morphology or physiology (GO:0044003)2.56868120
132positive regulation of macrophage cytokine production (GO:0060907)2.56645560
133phagosome maturation (GO:0090382)2.56404799
134leukocyte mediated cytotoxicity (GO:0001909)2.55934962
135lymphocyte chemotaxis (GO:0048247)2.55184765
136neutrophil migration (GO:1990266)2.53872817
137defense response to protozoan (GO:0042832)2.53487696
138response to interferon-alpha (GO:0035455)2.53308972

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse6.86101668
2* IRF8_22096565_ChIP-ChIP_GC-B_Human5.55371615
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.19515480
4* IRF8_27001747_Chip-Seq_BMDM_Mouse4.80529876
5* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.49779755
6* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.96672980
7NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.96476750
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.23062787
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.17421868
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.04646538
11MYB_21317192_ChIP-Seq_ERMYB_Mouse3.01546417
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.82352176
13NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.80605281
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.63560596
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.62049034
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.52349358
17* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.43654907
18STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.37248150
19RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.33839995
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.22361899
21PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse2.19840421
22SPI1_23127762_ChIP-Seq_K562_Human2.07756425
23ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.03585767
24SPI1_23547873_ChIP-Seq_NB4_Human2.03582416
25CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.99720813
26THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.94438315
27STAT4_19710469_ChIP-ChIP_TH1__Mouse1.92673750
28PU_27001747_Chip-Seq_BMDM_Mouse1.84362336
29STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.83997029
30SCL_19346495_ChIP-Seq_HPC-7_Human1.83684957
31VDR_24763502_ChIP-Seq_THP-1_Human1.82440854
32SMAD_19615063_ChIP-ChIP_OVARY_Human1.82397114
33VDR_24787735_ChIP-Seq_THP-1_Human1.79138149
34CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.74454666
35VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.74293121
36RUNX1_22412390_ChIP-Seq_EML_Mouse1.73478150
37VDR_21846776_ChIP-Seq_THP-1_Human1.70279479
38RXR_22158963_ChIP-Seq_LIVER_Mouse1.64096390
39RUNX_20019798_ChIP-Seq_JUKART_Human1.62333706
40RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.61815903
41GATA1_22025678_ChIP-Seq_K562_Human1.58430421
42* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.58105319
43PPARA_22158963_ChIP-Seq_LIVER_Mouse1.57047129
44STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.56049885
45* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.55932312
46* LXR_22158963_ChIP-Seq_LIVER_Mouse1.55263068
47MAF_26560356_Chip-Seq_TH1_Human1.53156098
48MYB_26560356_Chip-Seq_TH2_Human1.46889445
49E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.46852331
50* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.44898521
51* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.41780516
52GATA2_21666600_ChIP-Seq_HMVEC_Human1.41685441
53* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.31445936
54* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.30708450
55MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.30124742
56CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.30023621
57TCF7_22412390_ChIP-Seq_EML_Mouse1.26569634
58MYB_26560356_Chip-Seq_TH1_Human1.24651354
59CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.19456252
60* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17386735
61FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.17067428
62ELK3_25401928_ChIP-Seq_HUVEC_Human1.16353418
63SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15640938
64PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15316658
65KDM2B_26808549_Chip-Seq_SUP-B15_Human1.13940966
66IKZF1_21737484_ChIP-ChIP_HCT116_Human1.12764781
67UTX_26944678_Chip-Seq_JUKART_Human1.12207506
68GATA3_27048872_Chip-Seq_THYMUS_Human1.11887970
69SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.11235889
70SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.10801153
71SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10203867
72GATA2_22383799_ChIP-Seq_G1ME_Mouse1.09218861
73* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08082162
74TFEB_21752829_ChIP-Seq_HELA_Human1.06284832
75GATA3_26560356_Chip-Seq_TH2_Human1.06066515
76LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.06020055
77GATA1_19941826_ChIP-Seq_K562_Human1.05776704
78TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.05027538
79EGR1_23403033_ChIP-Seq_LIVER_Mouse1.04567526
80GATA1_19941827_ChIP-Seq_MEL_Mouse1.02250161
81VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.01056061
82KDM2B_26808549_Chip-Seq_JURKAT_Human1.00233200
83KDM2B_26808549_Chip-Seq_DND41_Human0.98127546
84PU.1_20513432_ChIP-Seq_Bcells_Mouse0.97572757
85GATA2_19941826_ChIP-Seq_K562_Human0.95288616
86GATA1_22383799_ChIP-Seq_G1ME_Mouse0.94341605
87MYC_22102868_ChIP-Seq_BL_Human0.93919405
88SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.93832458
89LXR_22292898_ChIP-Seq_THP-1_Human0.91967508
90FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.90388347
91GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.89926154
92KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.89899432
93KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.89661534
94TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.89089336
95FOXO3_23340844_ChIP-Seq_DLD1_Human0.88643218
96CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.88530826
97STAT6_21828071_ChIP-Seq_BEAS2B_Human0.86096435
98EGR1_19032775_ChIP-ChIP_M12_Human0.85907951
99SPI1_20517297_ChIP-Seq_HL60_Human0.82855608
100GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82825209
101GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82279786
102RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80436108
103RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.80336413
104LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.80103199
105BCL6_27268052_Chip-Seq_Bcells_Human0.79782669
106GATA1_19941827_ChIP-Seq_MEL86_Mouse0.79537059
107SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.78980761
108PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.78622317
109ESR1_21235772_ChIP-Seq_MCF-7_Human0.78555387
110BCOR_27268052_Chip-Seq_Bcells_Human0.77771203
111MAF_26560356_Chip-Seq_TH2_Human0.76968520
112CLOCK_20551151_ChIP-Seq_293T_Human0.76022615
113NCOR1_26117541_ChIP-Seq_K562_Human0.75471734
114ELF1_17652178_ChIP-ChIP_JURKAT_Human0.74932513
115KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.74913729
116RARG_19884340_ChIP-ChIP_MEFs_Mouse0.74311641
117SMRT_27268052_Chip-Seq_Bcells_Human0.71297829

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology4.90643105
2MP0003303_peritoneal_inflammation3.96223829
3MP0001835_abnormal_antigen_presentation3.87045619
4MP0006082_CNS_inflammation3.47050185
5MP0003172_abnormal_lysosome_physiology3.43540868
6MP0003436_decreased_susceptibility_to3.43362666
7MP0009840_abnormal_foam_cell3.20820551
8MP0002419_abnormal_innate_immunity3.05127356
9MP0003191_abnormal_cellular_cholesterol2.90240231
10MP0005000_abnormal_immune_tolerance2.63251419
11MP0005387_immune_system_phenotype2.43161906
12MP0001790_abnormal_immune_system2.43161906
13MP0009785_altered_susceptibility_to2.41731866
14MP0005025_abnormal_response_to2.39700041
15MP0002148_abnormal_hypersensitivity_rea2.35738033
16MP0002452_abnormal_antigen_presenting2.34968380
17MP0004510_myositis2.33547168
18MP0005464_abnormal_platelet_physiology2.26453782
19MP0003690_abnormal_glial_cell2.20089770
20MP0000604_amyloidosis2.17616548
21MP0000569_abnormal_digit_pigmentation2.16464241
22MP0001800_abnormal_humoral_immune2.13925012
23MP0003724_increased_susceptibility_to2.12929703
24MP0002723_abnormal_immune_serum2.09777486
25MP0003300_gastrointestinal_ulcer2.06093529
26MP0001533_abnormal_skeleton_physiology1.99951882
27MP0000685_abnormal_immune_system1.92465775
28MP0008260_abnormal_autophagy1.92069899
29MP0003763_abnormal_thymus_physiology1.88828392
30MP0001819_abnormal_immune_cell1.86974164
31MP0005671_abnormal_response_to1.86456372
32MP0002420_abnormal_adaptive_immunity1.84715771
33MP0003075_altered_response_to1.77097304
34MP0004947_skin_inflammation1.70155979
35MP0001845_abnormal_inflammatory_respons1.69287071
36MP0008469_abnormal_protein_level1.69040091
37MP0005257_abnormal_intraocular_pressure1.64876772
38MP0002405_respiratory_system_inflammati1.63206021
39MP0003448_altered_tumor_morphology1.63050839
40MP0003183_abnormal_peptide_metabolism1.62993999
41MP0000343_altered_response_to1.60707275
42MP0005451_abnormal_body_composition1.55533474
43MP0005310_abnormal_salivary_gland1.51814076
44MP0002132_abnormal_respiratory_system1.48132320
45MP0009278_abnormal_bone_marrow1.46985707
46MP0001853_heart_inflammation1.41684103
47MP0010307_abnormal_tumor_latency1.40290255
48MP0002998_abnormal_bone_remodeling1.40141501
49MP0009764_decreased_sensitivity_to1.39349913
50MP0003866_abnormal_defecation1.35279183
51MP0000716_abnormal_immune_system1.33842868
52MP0005166_decreased_susceptibility_to1.33829065
53MP0005167_abnormal_blood-brain_barrier1.31800809
54MP0000689_abnormal_spleen_morphology1.27772963
55MP0005083_abnormal_biliary_tract1.24754626
56MP0001851_eye_inflammation1.23391458
57MP0003566_abnormal_cell_adhesion1.19856241
58MP0010155_abnormal_intestine_physiology1.17904660
59MP0000703_abnormal_thymus_morphology1.15600772
60MP0000465_gastrointestinal_hemorrhage1.15297562
61MP0002398_abnormal_bone_marrow1.15077830
62MP0003705_abnormal_hypodermis_morpholog1.13922907
63MP0003656_abnormal_erythrocyte_physiolo1.13683660
64MP0008004_abnormal_stomach_pH1.10514264
65MP0005174_abnormal_tail_pigmentation1.08819510
66MP0002429_abnormal_blood_cell1.07634463
67MP0002166_altered_tumor_susceptibility1.06551850
68MP0004381_abnormal_hair_follicle1.06439255
69MP0000858_altered_metastatic_potential1.05680831
70MP0002090_abnormal_vision1.04466645
71MP0002722_abnormal_immune_system1.02840577
72MP0009333_abnormal_splenocyte_physiolog1.02473179
73MP0004782_abnormal_surfactant_physiolog0.99775603
74MP0002396_abnormal_hematopoietic_system0.98788929
75MP0005397_hematopoietic_system_phenotyp0.97465497
76MP0001545_abnormal_hematopoietic_system0.97465497
77MP0000609_abnormal_liver_physiology0.95026051
78MP0009763_increased_sensitivity_to0.94475010
79MP0008438_abnormal_cutaneous_collagen0.93568458
80MP0002006_tumorigenesis0.91720838
81MP0001958_emphysema0.90744049
82MP0005164_abnormal_response_to0.89884820
83MP0005076_abnormal_cell_differentiation0.89514540
84MP0002933_joint_inflammation0.89140597
85MP0005390_skeleton_phenotype0.88992198
86MP0002009_preneoplasia0.87331447
87MP0002254_reproductive_system_inflammat0.86723992
88MP0001663_abnormal_digestive_system0.86565648
89MP0010329_abnormal_lipoprotein_level0.86045430
90MP0000249_abnormal_blood_vessel0.85919746
91MP0003828_pulmonary_edema0.85026843
92MP0002277_abnormal_respiratory_mucosa0.83679336
93MP0005360_urolithiasis0.83011417
94MP0002139_abnormal_hepatobiliary_system0.81478291
95MP0004130_abnormal_muscle_cell0.78333278
96MP0004858_abnormal_nervous_system0.75235491
97MP0003806_abnormal_nucleotide_metabolis0.74931485
98MP0000920_abnormal_myelination0.74664109
99MP0002136_abnormal_kidney_physiology0.72816877
100MP0005319_abnormal_enzyme/_coenzyme0.71001436
101MP0000598_abnormal_liver_morphology0.70330533
102MP0000371_diluted_coat_color0.70227142
103MP0000767_abnormal_smooth_muscle0.68632292
104MP0004808_abnormal_hematopoietic_stem0.68495453
105MP0003795_abnormal_bone_structure0.68137135
106MP0006054_spinal_hemorrhage0.67805322
107MP0004883_abnormal_blood_vessel0.67644981
108MP0003091_abnormal_cell_migration0.67554346
109MP0001873_stomach_inflammation0.65974814
110MP0005075_abnormal_melanosome_morpholog0.65756975
111MP0009765_abnormal_xenobiotic_induced0.64248727
112MP0002138_abnormal_hepatobiliary_system0.63592768
113MP0003195_calcinosis0.63135067
114MP0008875_abnormal_xenobiotic_pharmacok0.62940084
115MP0005584_abnormal_enzyme/coenzyme_acti0.62938386
116MP0000015_abnormal_ear_pigmentation0.62758501
117MP0004185_abnormal_adipocyte_glucose0.62432972
118MP0000490_abnormal_crypts_of0.61066909
119MP0008874_decreased_physiological_sensi0.60335402
120MP0003045_fibrosis0.58938120
121MP0001986_abnormal_taste_sensitivity0.58520089
122MP0003221_abnormal_cardiomyocyte_apopto0.57250198
123MP0003329_amyloid_beta_deposits0.55946593
124MP0003453_abnormal_keratinocyte_physiol0.53767187
125MP0002133_abnormal_respiratory_system0.51656700
126MP0005388_respiratory_system_phenotype0.51656700

Predicted human phenotypes

RankGene SetZ-score
1Increased cerebral lipofuscin (HP:0011813)6.66913008
2Recurrent abscess formation (HP:0002722)6.26120932
3Systemic lupus erythematosus (HP:0002725)5.77456805
4Vacuolated lymphocytes (HP:0001922)5.68830808
5Recurrent bacterial skin infections (HP:0005406)5.64311115
6Increased neuronal autofluorescent lipopigment (HP:0002074)5.54892703
7Recurrent gram-negative bacterial infections (HP:0005420)5.51067963
8Eczematoid dermatitis (HP:0000976)5.50598393
9Abnormality of glycolipid metabolism (HP:0010969)5.07325765
10Abnormality of liposaccharide metabolism (HP:0010968)5.07325765
11Abnormality of glycosphingolipid metabolism (HP:0004343)5.07325765
12Abnormality of macrophages (HP:0004311)4.88954823
13Dysostosis multiplex (HP:0000943)4.80664768
14Glomerulonephritis (HP:0000099)4.35287581
15Disinhibition (HP:0000734)4.20256624
16Axonal loss (HP:0003447)4.05794198
17Urinary glycosaminoglycan excretion (HP:0003541)4.00960766
18Mucopolysacchariduria (HP:0008155)4.00960766
19Gastrointestinal infarctions (HP:0005244)3.82400331
20Abnormality of polysaccharide metabolism (HP:0011012)3.81681139
21Abnormality of glycosaminoglycan metabolism (HP:0004371)3.81681139
22Abnormality of mucopolysaccharide metabolism (HP:0011020)3.81681139
23Loss of speech (HP:0002371)3.68874181
24Complement deficiency (HP:0004431)3.58612648
25Keratoconjunctivitis sicca (HP:0001097)3.57082790
26Recurrent skin infections (HP:0001581)3.40587398
27Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.40237439
28Encephalitis (HP:0002383)3.37644858
29Autoimmune thrombocytopenia (HP:0001973)3.37159210
30Abnormal delayed hypersensitivity skin test (HP:0002963)3.34898850
31Myocardial infarction (HP:0001658)3.33395143
32Mediastinal lymphadenopathy (HP:0100721)3.32389358
33Gingivitis (HP:0000230)3.32097800
34Keratoconjunctivitis (HP:0001096)3.27420594
35Hemoptysis (HP:0002105)3.20382882
36Chronic obstructive pulmonary disease (HP:0006510)3.19872027
37Obstructive lung disease (HP:0006536)3.19872027
38Abnormality of complement system (HP:0005339)3.18230159
39Myositis (HP:0100614)3.16080115
40T lymphocytopenia (HP:0005403)3.09863290
41Chest pain (HP:0100749)2.99981266
42Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.97619083
43Abnormality of T cell number (HP:0011839)2.93889417
44Orchitis (HP:0100796)2.93373704
45Prolonged bleeding time (HP:0003010)2.93130801
46Increased IgE level (HP:0003212)2.92158066
47Upper motor neuron abnormality (HP:0002127)2.87998266
48Agnosia (HP:0010524)2.85533127
49Hepatosplenomegaly (HP:0001433)2.83207636
50Elevated erythrocyte sedimentation rate (HP:0003565)2.80415954
51Nephritis (HP:0000123)2.79918021
52Hematochezia (HP:0002573)2.76936700
53Recurrent fungal infections (HP:0002841)2.75823560
54Episodic fever (HP:0001954)2.71262641
55Epistaxis (HP:0000421)2.66856282
56Pulmonary embolism (HP:0002204)2.59587305
57J-shaped sella turcica (HP:0002680)2.57923677
58Neuronal loss in central nervous system (HP:0002529)2.57699640
59Interstitial pulmonary disease (HP:0006530)2.56171252
60Peritonitis (HP:0002586)2.51669838
61Periodontitis (HP:0000704)2.49970186
62Abnormality of the vasculature of the conjunctiva (HP:0008054)2.49673278
63Retinal atrophy (HP:0001105)2.48407712
64Basal ganglia calcification (HP:0002135)2.47551155
65Joint hemorrhage (HP:0005261)2.47282178
66Purpura (HP:0000979)2.46945384
67Mutism (HP:0002300)2.45905163
68Cellulitis (HP:0100658)2.44716027
69Thoracic kyphosis (HP:0002942)2.44216870
70Optic neuritis (HP:0100653)2.43922004
71Retrobulbar optic neuritis (HP:0100654)2.43922004
72Pathologic fracture (HP:0002756)2.43736234
73Abnormality of the lumbar spine (HP:0100712)2.42580861
74Stomatitis (HP:0010280)2.42038346
75Recurrent viral infections (HP:0004429)2.41014953
76Petechiae (HP:0000967)2.40654129
77Gangrene (HP:0100758)2.40462710
78Anorexia (HP:0002039)2.39975823
79Spontaneous hematomas (HP:0007420)2.38532460
80Urticaria (HP:0001025)2.37951589
81Asymmetric septal hypertrophy (HP:0001670)2.37654853
82Thick nail (HP:0001805)2.36158847
83Peripheral demyelination (HP:0011096)2.35436953
84Abnormality of T cells (HP:0002843)2.35294757
85Pustule (HP:0200039)2.34449976
86Conjunctival telangiectasia (HP:0000524)2.32359458
87Vasculitis (HP:0002633)2.32164540
88Panhypogammaglobulinemia (HP:0003139)2.29478910
89Apathy (HP:0000741)2.25911898
90Global brain atrophy (HP:0002283)2.25491212
91Increased IgM level (HP:0003496)2.24601637
92Abnormality of the pleura (HP:0002103)2.24363826
93Diminished motivation (HP:0000745)2.24177762
94Increased CSF protein (HP:0002922)2.23992553
95Increased serum ferritin (HP:0003281)2.22629164
96Chronic otitis media (HP:0000389)2.20974434
97Prostate neoplasm (HP:0100787)2.19714890
98Colitis (HP:0002583)2.19328745
99Vertigo (HP:0002321)2.18084794
100Osteomyelitis (HP:0002754)2.17933766
101Amyloidosis (HP:0011034)2.16018533
102Inappropriate behavior (HP:0000719)2.14794408
103Polyneuropathy (HP:0001271)2.14659942
104Granulocytopenia (HP:0001913)2.12903472
105Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.12561492
106Malnutrition (HP:0004395)2.12098319
107Sepsis (HP:0100806)2.10158414
108Amaurosis fugax (HP:0100576)2.09562338
109Neurofibrillary tangles (HP:0002185)2.06549666
110Tetraparesis (HP:0002273)2.06131157
111Glomerulopathy (HP:0100820)2.04312829
112Gingival bleeding (HP:0000225)2.03363499
113Abnormality of the peritoneum (HP:0002585)2.03106386
114Bone pain (HP:0002653)2.02267384
115Abnormality of the endocardium (HP:0004306)2.02211508
116Hypercholesterolemia (HP:0003124)2.00901844
117Lymphopenia (HP:0001888)2.00513339
118Abnormality of iron homeostasis (HP:0011031)1.98838806
119Agammaglobulinemia (HP:0004432)1.98586842
120Hypergammaglobulinemia (HP:0010702)1.98446556
121Osteolytic defects of the hand bones (HP:0009699)1.97987378
122Osteolytic defects of the phalanges of the hand (HP:0009771)1.97987378
123Inflammation of the large intestine (HP:0002037)1.96431803
124Progressive visual loss (HP:0000529)1.94525818
125Supranuclear gaze palsy (HP:0000605)1.94262596
126Skin ulcer (HP:0200042)1.94081844
127Progressive neurologic deterioration (HP:0002344)1.93646841
128Personality changes (HP:0000751)1.93253953
129Arterial thrombosis (HP:0004420)1.92695162
130Esophageal varix (HP:0002040)1.92593270
131Hypochromic anemia (HP:0001931)1.91548935
132Chronic mucocutaneous candidiasis (HP:0002728)1.91383327
133Recurrent cutaneous fungal infections (HP:0011370)1.91383327
134Meningitis (HP:0001287)1.90630616
135Thrombocytosis (HP:0001894)1.89477226
136Cerebral aneurysm (HP:0004944)1.89394172
137Abnormality of cells of the lymphoid lineage (HP:0012140)1.88590123
138Pulmonary infiltrates (HP:0002113)1.88571208
139Eosinophilia (HP:0001880)1.88423983
140Acne (HP:0001061)1.88212891
141Viral hepatitis (HP:0006562)1.84636303
142Cheilitis (HP:0100825)1.84174391
143Leukocytosis (HP:0001974)1.84068352
144Abnormality of the thoracic spine (HP:0100711)1.83396507
145Gastrointestinal inflammation (HP:0004386)1.80952377
146Recurrent pneumonia (HP:0006532)1.78077411

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK3.62050513
2RIPK43.53442800
3TYK23.49261924
4TGFBR23.27487628
5ERN13.24867352
6TBK13.20523082
7KIT3.12640144
8PRPF4B2.92041741
9IRAK42.74826719
10MAP4K12.71386461
11MAP3K142.57782055
12IRAK32.46155058
13CSF1R2.34328217
14JAK12.05246235
15CAMK1D1.93612236
16IKBKE1.89237865
17TAOK31.86898336
18CSK1.76523540
19TRIB31.74730599
20FES1.70590837
21TNK21.70585845
22EPHB11.67049342
23IKBKB1.60450150
24ZAP701.56392514
25FGR1.53791981
26HCK1.52754370
27JAK31.48690922
28MAP3K131.48561778
29NEK91.43500424
30TAOK11.43289201
31SYK1.39641033
32MAP2K31.38816422
33CAMK1G1.36380156
34JAK21.35201652
35PKN21.32080569
36RIPK11.31821088
37STK101.30578730
38BMPR21.30088444
39PBK1.23442033
40SCYL21.20264727
41MATK1.18470366
42LYN1.17265342
43YES11.13951683
44TTN1.13637575
45FGFR41.12348697
46SIK31.11782100
47PTK61.10365377
48GRK71.09274607
49LCK1.09228381
50BTK1.06453960
51PAK41.01174840
52IRAK10.93573841
53IRAK20.91460105
54CAMKK20.90900645
55SIK20.90401417
56ITK0.89262489
57TXK0.88892849
58EGFR0.88813436
59FGFR30.88173189
60MARK20.86757342
61MAP3K30.86525552
62LRRK20.84829871
63RPS6KA40.83850122
64MARK30.83786895
65ABL20.81203662
66MAPK70.80272483
67CDC42BPA0.80163910
68TAOK20.79935215
69CDK60.79089811
70CHUK0.79088063
71GRK60.78481900
72CLK10.77609454
73BMX0.76264943
74CAMKK10.73763679
75MAPK120.70799954
76PIM20.70443798
77ABL10.67128467
78MOS0.66879714
79TEC0.65007595
80KSR20.63712710
81PRKCD0.62099543
82NME20.61602711
83PIM10.61041867
84CDK190.60830317
85CDK120.58851672
86PDPK10.55507164
87MAP3K60.55121419
88MAP3K110.54505274
89FYN0.53943542
90PRKD20.53924475
91MAP3K100.53798580
92MAP3K70.51503390
93TESK20.50464357
94PDK10.49203760
95NLK0.49128884
96TRPM70.46853334
97HIPK20.45625991
98SGK20.44785429
99DYRK1B0.44524206
100KSR10.42912185
101DAPK20.41547053
102MAP3K10.41378005
103RPS6KL10.40818050
104RPS6KC10.40818050
105STK40.40387756
106EPHA30.40180789
107STK110.38936714
108PIK3CG0.38489744
109PRKCH0.37021549
110GSK3A0.36881514
111IGF1R0.36455291
112MAP3K50.35079217
113STK30.35071757
114RET0.34526937
115RPS6KA60.34143862
116ALK0.33796242
117RAF10.32011558
118MAP2K40.31674420
119MAPKAPK20.31505169
120PTK2B0.31303768
121PDGFRB0.30816202
122SIK10.30726869
123MAP3K20.30707628
124SRC0.28170506
125MAPK40.28162534
126PRKCQ0.27701603
127SGK30.27407663
128MAPK150.26586436
129RPS6KA20.26098050
130MAP3K90.26081930

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051504.36257260
2Glycosaminoglycan degradation_Homo sapiens_hsa005313.98212528
3Lysosome_Homo sapiens_hsa041423.63191848
4Leishmaniasis_Homo sapiens_hsa051403.04263103
5Other glycan degradation_Homo sapiens_hsa005112.91326512
6Osteoclast differentiation_Homo sapiens_hsa043802.65308926
7Toll-like receptor signaling pathway_Homo sapiens_hsa046202.52684264
8Autoimmune thyroid disease_Homo sapiens_hsa053202.43240149
9Tuberculosis_Homo sapiens_hsa051522.29442514
10Pertussis_Homo sapiens_hsa051332.29329730
11Phagosome_Homo sapiens_hsa041452.03747015
12B cell receptor signaling pathway_Homo sapiens_hsa046621.93915009
13Malaria_Homo sapiens_hsa051441.91876248
14Complement and coagulation cascades_Homo sapiens_hsa046101.91717167
15Legionellosis_Homo sapiens_hsa051341.79080763
16Antigen processing and presentation_Homo sapiens_hsa046121.74561888
17NF-kappa B signaling pathway_Homo sapiens_hsa040641.74514676
18Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.66598574
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.62657503
20Rheumatoid arthritis_Homo sapiens_hsa053231.61512585
21Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.61415541
22Measles_Homo sapiens_hsa051621.56450072
23Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.55183808
24Caffeine metabolism_Homo sapiens_hsa002321.54498479
25Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.46846484
26Toxoplasmosis_Homo sapiens_hsa051451.42859431
27Influenza A_Homo sapiens_hsa051641.41668059
28RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.35667125
29NOD-like receptor signaling pathway_Homo sapiens_hsa046211.33248005
30Salmonella infection_Homo sapiens_hsa051321.30866057
31Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.24295444
32Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.23790636
33Apoptosis_Homo sapiens_hsa042101.22035333
34TNF signaling pathway_Homo sapiens_hsa046681.18909842
35Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.17418104
36Chemokine signaling pathway_Homo sapiens_hsa040621.13972080
37Shigellosis_Homo sapiens_hsa051311.10430283
38Graft-versus-host disease_Homo sapiens_hsa053321.05190658
39Hematopoietic cell lineage_Homo sapiens_hsa046401.04315046
40Pentose and glucuronate interconversions_Homo sapiens_hsa000401.01651878
41Prion diseases_Homo sapiens_hsa050201.01036303
42Asthma_Homo sapiens_hsa053100.98068315
43Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.97794395
44Intestinal immune network for IgA production_Homo sapiens_hsa046720.96788705
45Leukocyte transendothelial migration_Homo sapiens_hsa046700.95201809
46Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.93127852
47Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.91961438
48Hepatitis C_Homo sapiens_hsa051600.91195178
49Hepatitis B_Homo sapiens_hsa051610.90049001
50African trypanosomiasis_Homo sapiens_hsa051430.87422854
51Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.87322131
52Primary bile acid biosynthesis_Homo sapiens_hsa001200.86070543
53Herpes simplex infection_Homo sapiens_hsa051680.84402399
54Jak-STAT signaling pathway_Homo sapiens_hsa046300.84292697
55Amoebiasis_Homo sapiens_hsa051460.84205860
56Collecting duct acid secretion_Homo sapiens_hsa049660.81013817
57Nitrogen metabolism_Homo sapiens_hsa009100.79680666
58Allograft rejection_Homo sapiens_hsa053300.79506944
59Chronic myeloid leukemia_Homo sapiens_hsa052200.78916030
60Pancreatic cancer_Homo sapiens_hsa052120.77963816
61Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.77039991
62Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.75620243
63AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.74939209
64Acute myeloid leukemia_Homo sapiens_hsa052210.69227578
65Sphingolipid metabolism_Homo sapiens_hsa006000.67480148
66Platelet activation_Homo sapiens_hsa046110.67232017
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.62924624
68Endocytosis_Homo sapiens_hsa041440.62906003
69Viral myocarditis_Homo sapiens_hsa054160.61041128
70GnRH signaling pathway_Homo sapiens_hsa049120.60246568
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60029200
72ABC transporters_Homo sapiens_hsa020100.58801485
73Sphingolipid signaling pathway_Homo sapiens_hsa040710.58218186
74T cell receptor signaling pathway_Homo sapiens_hsa046600.56259866
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.55373872
76Steroid biosynthesis_Homo sapiens_hsa001000.54760927
77FoxO signaling pathway_Homo sapiens_hsa040680.54257622
78Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.54157422
79Renin-angiotensin system_Homo sapiens_hsa046140.50782427
80Phosphatidylinositol signaling system_Homo sapiens_hsa040700.50153017
81Endometrial cancer_Homo sapiens_hsa052130.48894791
82PPAR signaling pathway_Homo sapiens_hsa033200.48476277
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48437532
84Mineral absorption_Homo sapiens_hsa049780.47802224
85Choline metabolism in cancer_Homo sapiens_hsa052310.47773268
86Type II diabetes mellitus_Homo sapiens_hsa049300.47154583
87HTLV-I infection_Homo sapiens_hsa051660.46957613
88Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46907327
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46797332
90Arginine biosynthesis_Homo sapiens_hsa002200.43368646
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43272710
92Viral carcinogenesis_Homo sapiens_hsa052030.43149566
93Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43087092
94Prolactin signaling pathway_Homo sapiens_hsa049170.41805493
95mTOR signaling pathway_Homo sapiens_hsa041500.41732883
96HIF-1 signaling pathway_Homo sapiens_hsa040660.40119148
97Insulin resistance_Homo sapiens_hsa049310.39410098
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39374966
99Histidine metabolism_Homo sapiens_hsa003400.39180625
100VEGF signaling pathway_Homo sapiens_hsa043700.38578708
101Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36772466
102Renal cell carcinoma_Homo sapiens_hsa052110.36154454
103Inositol phosphate metabolism_Homo sapiens_hsa005620.35903540
104Colorectal cancer_Homo sapiens_hsa052100.35315487
105Proteoglycans in cancer_Homo sapiens_hsa052050.34623203
106Estrogen signaling pathway_Homo sapiens_hsa049150.33873793
107MAPK signaling pathway_Homo sapiens_hsa040100.33233494
108Starch and sucrose metabolism_Homo sapiens_hsa005000.33080514
109Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33079074
110Prostate cancer_Homo sapiens_hsa052150.29762402
111Notch signaling pathway_Homo sapiens_hsa043300.29485928
112Primary immunodeficiency_Homo sapiens_hsa053400.29404158
113Rap1 signaling pathway_Homo sapiens_hsa040150.28970152
114ErbB signaling pathway_Homo sapiens_hsa040120.28829521
115Dorso-ventral axis formation_Homo sapiens_hsa043200.27502178
116Non-small cell lung cancer_Homo sapiens_hsa052230.22524181
117Epstein-Barr virus infection_Homo sapiens_hsa051690.21386663
118Type I diabetes mellitus_Homo sapiens_hsa049400.21267047
119Phospholipase D signaling pathway_Homo sapiens_hsa040720.20909080
120Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.19941836
121Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.19850425
122Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.19384635

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