MPDZ

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene has multiple PDZ domains, which are hallmarks of protein-protein interactions. The encoded protein is known to interact with the HTR2C receptor and may cause it to clump at the cell surface. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1plasma membrane repair (GO:0001778)4.18399085
2presynaptic membrane assembly (GO:0097105)3.60233183
3cardiac myofibril assembly (GO:0055003)3.53724999
4insulin-like growth factor receptor signaling pathway (GO:0048009)3.40145767
5presynaptic membrane organization (GO:0097090)3.33499794
6establishment of nucleus localization (GO:0040023)3.25952720
7sequestering of extracellular ligand from receptor (GO:0035581)3.11585376
8positive regulation of fatty acid beta-oxidation (GO:0032000)2.97529018
9positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.93574841
10pyrimidine nucleobase catabolic process (GO:0006208)2.92957715
11regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.91109846
12myofibril assembly (GO:0030239)2.90372767
13neuron projection extension involved in neuron projection guidance (GO:1902284)2.89023081
14axon extension involved in axon guidance (GO:0048846)2.89023081
15postsynaptic membrane organization (GO:0001941)2.87835944
16cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.87284886
17carnitine shuttle (GO:0006853)2.76174144
18hippo signaling (GO:0035329)2.75675151
19positive regulation of glycogen biosynthetic process (GO:0045725)2.73417238
20cell communication by electrical coupling (GO:0010644)2.72966260
21nucleus localization (GO:0051647)2.70830640
22central nervous system myelination (GO:0022010)2.70616102
23axon ensheathment in central nervous system (GO:0032291)2.70616102
24neuromuscular junction development (GO:0007528)2.70375196
25regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.69265292
26positive regulation of fatty acid oxidation (GO:0046321)2.67967109
27limb bud formation (GO:0060174)2.66119551
28regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.60711384
29negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.60578707
30regulation of axon extension involved in axon guidance (GO:0048841)2.58912076
31heart morphogenesis (GO:0003007)2.58715161
32fatty acid transmembrane transport (GO:1902001)2.58321532
33collagen fibril organization (GO:0030199)2.56162868
34camera-type eye morphogenesis (GO:0048593)2.55137053
35axonal fasciculation (GO:0007413)2.54910524
36lateral sprouting from an epithelium (GO:0060601)2.53760286
37appendage development (GO:0048736)2.52310687
38limb development (GO:0060173)2.52310687
39regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.52205567
40paraxial mesoderm development (GO:0048339)2.49758500
41notochord development (GO:0030903)2.49559908
42sarcomere organization (GO:0045214)2.47468926
43negative regulation of potassium ion transmembrane transport (GO:1901380)2.47093699
44negative regulation of catenin import into nucleus (GO:0035414)2.46765976
45regulation of fatty acid beta-oxidation (GO:0031998)2.45336970
46embryonic retina morphogenesis in camera-type eye (GO:0060059)2.44437770
47retina vasculature morphogenesis in camera-type eye (GO:0061299)2.44394629
48apical protein localization (GO:0045176)2.44302745
49cerebral cortex radially oriented cell migration (GO:0021799)2.42947354
50cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.41698585
51positive regulation of glycogen metabolic process (GO:0070875)2.41066933
52layer formation in cerebral cortex (GO:0021819)2.40977113
53actin-myosin filament sliding (GO:0033275)2.39727400
54muscle filament sliding (GO:0030049)2.39727400
55positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.38875616
56protein heterotrimerization (GO:0070208)2.37028904
57axon extension (GO:0048675)2.36342753
58regulation of axon guidance (GO:1902667)2.35338070
59chondrocyte proliferation (GO:0035988)2.35193453
60regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.33917327
61artery development (GO:0060840)2.32461758
62negative chemotaxis (GO:0050919)2.32303901
63cardiac muscle cell proliferation (GO:0060038)2.31656640
64bone trabecula formation (GO:0060346)2.31643367
65neuronal ion channel clustering (GO:0045161)2.31400125
66otic vesicle formation (GO:0030916)2.31085503
67retinal ganglion cell axon guidance (GO:0031290)2.30953636
68actomyosin structure organization (GO:0031032)2.28519239
69neuronal stem cell maintenance (GO:0097150)2.28159892
70dendritic spine morphogenesis (GO:0060997)2.26405394
71cell communication involved in cardiac conduction (GO:0086065)2.25788965
72regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.24769867
73embryonic foregut morphogenesis (GO:0048617)2.24517632
74nucleobase catabolic process (GO:0046113)2.24441228
75glomerular filtration (GO:0003094)2.24312791
76vocalization behavior (GO:0071625)2.23271548
77regulation of fatty acid oxidation (GO:0046320)2.22742743
78neuron recognition (GO:0008038)2.22000168
79central nervous system projection neuron axonogenesis (GO:0021952)2.21887978
80dendrite morphogenesis (GO:0048813)2.21742300
81regulation of short-term neuronal synaptic plasticity (GO:0048172)2.21511761
82neuron cell-cell adhesion (GO:0007158)2.21154800
83actin-mediated cell contraction (GO:0070252)2.20609209
84epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.20441709
85cardiac muscle contraction (GO:0060048)2.19436089
86adherens junction assembly (GO:0034333)2.19315748
87heart trabecula formation (GO:0060347)2.18873587
88lymphangiogenesis (GO:0001946)2.18379226
89regulation of skeletal muscle contraction (GO:0014819)2.17938354
90regulation of non-canonical Wnt signaling pathway (GO:2000050)2.17849401
91activation of protein kinase A activity (GO:0034199)2.17437843
92dorsal/ventral axis specification (GO:0009950)2.17421501
93negative regulation of axon guidance (GO:1902668)2.17353708
94negative regulation of cytosolic calcium ion concentration (GO:0051481)2.17319863
95metanephric mesenchyme development (GO:0072075)2.16392411
96regulation of membrane repolarization (GO:0060306)2.16355517
97cytoskeletal anchoring at plasma membrane (GO:0007016)2.15770647
98myelination in peripheral nervous system (GO:0022011)2.15330592
99peripheral nervous system axon ensheathment (GO:0032292)2.15330592
100midgut development (GO:0007494)2.13463361
101membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.13342130
102negative regulation of axon extension involved in axon guidance (GO:0048843)2.12655163
103endocardial cushion development (GO:0003197)2.11719215
104trabecula formation (GO:0060343)2.11369295
105positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.10379143
106negative regulation of chondrocyte differentiation (GO:0032331)2.10359710
107adult heart development (GO:0007512)2.09560603
108regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.09555206
109asymmetric protein localization (GO:0008105)2.09288242
110negative regulation of vascular permeability (GO:0043116)2.09191282
111cellular response to cholesterol (GO:0071397)2.08653981
112membrane assembly (GO:0071709)2.08644911
113neurotransmitter-gated ion channel clustering (GO:0072578)2.07602642
114locomotory exploration behavior (GO:0035641)2.07556513
115synaptic vesicle docking involved in exocytosis (GO:0016081)2.07306281
116regulation of potassium ion transmembrane transporter activity (GO:1901016)2.07033875
117regulation of actin filament-based movement (GO:1903115)2.06703535
118positive regulation of cardiac muscle tissue growth (GO:0055023)2.06079891
119branching involved in salivary gland morphogenesis (GO:0060445)2.05938532
120cell migration involved in sprouting angiogenesis (GO:0002042)2.05710904
121renal filtration (GO:0097205)2.05286746
122regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.04987961
123regulation of cardiac muscle cell contraction (GO:0086004)2.04973447
124negative regulation of protein localization to cell surface (GO:2000009)2.04677583
125positive regulation of glucose import (GO:0046326)2.04666381
126negative regulation of Rho protein signal transduction (GO:0035024)2.04510470
127innervation (GO:0060384)2.04485175
128myoblast fusion (GO:0007520)2.04049372
129mesenchymal-epithelial cell signaling (GO:0060638)2.04005359
130cell migration in hindbrain (GO:0021535)2.03878973
131gastrulation with mouth forming second (GO:0001702)2.03872359
132kidney mesenchyme development (GO:0072074)2.03514364
133cardiac cell development (GO:0055006)2.03506581
134regulation of cell communication by electrical coupling (GO:0010649)2.03020146
135intraciliary transport (GO:0042073)2.03002269
136convergent extension (GO:0060026)2.02941561
137peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.02735957
138chondrocyte development (GO:0002063)2.02693129
139sarcoplasmic reticulum calcium ion transport (GO:0070296)2.02604014
140cerebral cortex cell migration (GO:0021795)2.02378184
141positive regulation of cellular response to insulin stimulus (GO:1900078)2.01927971
142spinal cord development (GO:0021510)2.01826292
143protein localization to cell surface (GO:0034394)2.01290347
144negative regulation of astrocyte differentiation (GO:0048712)2.01011484
145cardiac muscle cell development (GO:0055013)2.00899627
146positive regulation of heart growth (GO:0060421)2.00862635
147regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.00305129
148somite development (GO:0061053)1.99250342
149planar cell polarity pathway involved in neural tube closure (GO:0090179)1.98524579
150morphogenesis of an epithelial sheet (GO:0002011)1.98507029
151Wnt signaling pathway, planar cell polarity pathway (GO:0060071)1.97451035
152G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071991.96806658
153astrocyte development (GO:0014002)1.96254494
154developmental induction (GO:0031128)1.95985859
155regulation of cardioblast differentiation (GO:0051890)1.95922655
156regulation of heart morphogenesis (GO:2000826)1.95695159
157cell-cell signaling involved in cell fate commitment (GO:0045168)1.95592615
158neuron projection extension (GO:1990138)1.95522239
159mesenchyme morphogenesis (GO:0072132)1.95100807
160positive regulation of cardiac muscle tissue development (GO:0055025)1.94546223
161mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)1.94104466
162cerebral cortex development (GO:0021987)1.94061209

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.07129805
2GBX2_23144817_ChIP-Seq_PC3_Human2.54789367
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.41602975
4EZH2_18974828_ChIP-Seq_MESCs_Mouse2.36344520
5RNF2_18974828_ChIP-Seq_MESCs_Mouse2.36344520
6* EP300_21415370_ChIP-Seq_HL-1_Mouse2.19012419
7EED_16625203_ChIP-ChIP_MESCs_Mouse2.15432284
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.14634457
9* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.08535439
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.07524173
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.06483092
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.96636296
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.94786351
14ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.93505702
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.93032964
16JARID2_20075857_ChIP-Seq_MESCs_Mouse1.92894534
17* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.91285008
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.90920412
19CDX2_19796622_ChIP-Seq_MESCs_Mouse1.86539530
20* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.85954339
21PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.85063467
22TRIM28_21343339_ChIP-Seq_HEK293_Human1.84914845
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.83621105
24NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.79223187
25FUS_26573619_Chip-Seq_HEK293_Human1.72559869
26RNF2_27304074_Chip-Seq_ESCs_Mouse1.72229063
27DROSHA_22980978_ChIP-Seq_HELA_Human1.71008391
28EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.70188957
29PIAS1_25552417_ChIP-Seq_VCAP_Human1.62751073
30* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.60944744
31* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.58722378
32WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.58060865
33CLOCK_20551151_ChIP-Seq_293T_Human1.55436783
34* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.53321350
35EZH2_27294783_Chip-Seq_ESCs_Mouse1.52135185
36* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.51963710
37AR_21572438_ChIP-Seq_LNCaP_Human1.50988130
38PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.50778966
39WT1_19549856_ChIP-ChIP_CCG9911_Human1.49638521
40RBPJ_22232070_ChIP-Seq_NCS_Mouse1.48654392
41* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.47423237
42IGF1R_20145208_ChIP-Seq_DFB_Human1.42791711
43TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42684166
44SMAD4_21799915_ChIP-Seq_A2780_Human1.42472232
45GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41888379
46ISL1_27105846_Chip-Seq_CPCs_Mouse1.40844198
47* ESR1_20079471_ChIP-ChIP_T-47D_Human1.40786144
48* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.40361763
49SUZ12_27294783_Chip-Seq_ESCs_Mouse1.37465641
50PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.36734772
51ZNF274_21170338_ChIP-Seq_K562_Hela1.36423310
52* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.36248864
53RNF2_27304074_Chip-Seq_NSC_Mouse1.35822890
54POU5F1_16153702_ChIP-ChIP_HESCs_Human1.34550532
55TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33733859
56* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.33489696
57TP53_16413492_ChIP-PET_HCT116_Human1.33372181
58SMAD_19615063_ChIP-ChIP_OVARY_Human1.32045067
59PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.31348590
60STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.29898979
61NR3C1_23031785_ChIP-Seq_PC12_Mouse1.29583820
62BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.29261371
63* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.29020156
64* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.28565734
65NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.27982945
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26338541
67* SOX9_26525672_Chip-Seq_HEART_Mouse1.25269863
68* SOX2_21211035_ChIP-Seq_LN229_Gbm1.25147220
69CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.24889876
70NRF2_20460467_ChIP-Seq_MEFs_Mouse1.24733038
71NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.24733038
72TBX3_20139965_ChIP-Seq_MESCs_Mouse1.24513424
73SALL1_21062744_ChIP-ChIP_HESCs_Human1.24471267
74DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.24229057
75TBX3_20139965_ChIP-Seq_ESCs_Mouse1.23957668
76* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23232860
77KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.22417936
78AR_19668381_ChIP-Seq_PC3_Human1.21073521
79HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.20525822
80* CBX2_27304074_Chip-Seq_ESCs_Mouse1.20203869
81LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19940067
82EWS_26573619_Chip-Seq_HEK293_Human1.19691306
83* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19593518
84POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19583988
85TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19583988
86CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19187972
87RARG_19884340_ChIP-ChIP_MEFs_Mouse1.18098355
88* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18096655
89STAT3_23295773_ChIP-Seq_U87_Human1.17709512
90RING1B_27294783_Chip-Seq_NPCs_Mouse1.15703924
91BCAT_22108803_ChIP-Seq_LS180_Human1.14749287
92CJUN_26792858_Chip-Seq_BT549_Human1.14526697
93* ARNT_22903824_ChIP-Seq_MCF-7_Human1.14044997
94RING1B_27294783_Chip-Seq_ESCs_Mouse1.14014223
95SMAD3_21741376_ChIP-Seq_EPCs_Human1.13740928
96NANOG_18555785_Chip-Seq_ESCs_Mouse1.13740740
97TCF4_18268006_ChIP-ChIP_LS174T_Human1.13697077
98TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.13206048
99YAP1_20516196_ChIP-Seq_MESCs_Mouse1.11889385
100NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11584077
101* AHR_22903824_ChIP-Seq_MCF-7_Human1.10388917
102UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10385421
103TAF15_26573619_Chip-Seq_HEK293_Human1.10127667
104TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09719456
105CTNNB1_20460455_ChIP-Seq_HCT116_Human1.09235707
106* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06506936
107* TBX20_22328084_ChIP-Seq_HEART_Mouse1.06019382
108* TBX20_22080862_ChIP-Seq_HEART_Mouse1.06019382
109SMAD3_21741376_ChIP-Seq_HESCs_Human1.06004619
110RARB_27405468_Chip-Seq_BRAIN_Mouse1.05394389
111POU3F2_20337985_ChIP-ChIP_501MEL_Human1.05123748
112* RUNX2_22187159_ChIP-Seq_PCA_Human1.04991415
113* P300_19829295_ChIP-Seq_ESCs_Human1.04642044
114* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.03929479
115TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03876439
116CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03761379
117EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03096394
118TP53_18474530_ChIP-ChIP_U2OS_Human1.03055882
119TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.02061993
120* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.00519683
121* AR_25329375_ChIP-Seq_VCAP_Human1.00316297
122SMAD4_21741376_ChIP-Seq_HESCs_Human1.00055380
123TP53_20018659_ChIP-ChIP_R1E_Mouse0.98725595
124KDM2B_26808549_Chip-Seq_K562_Human0.98478502
125HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.97866303
126SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.96590991
127TCF4_23295773_ChIP-Seq_U87_Human0.96289141

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.85158809
2MP0002837_dystrophic_cardiac_calcinosis3.03002312
3MP0004272_abnormal_basement_membrane2.91444189
4MP0004145_abnormal_muscle_electrophysio2.86881033
5MP0000751_myopathy2.85445392
6MP0003705_abnormal_hypodermis_morpholog2.76282590
7MP0005503_abnormal_tendon_morphology2.32884698
8MP0005275_abnormal_skin_tensile2.27936521
9MP0010368_abnormal_lymphatic_system2.06690251
10MP0000566_synostosis2.03797926
11MP0004084_abnormal_cardiac_muscle2.00325789
12MP0005623_abnormal_meninges_morphology1.97338933
13MP0003136_yellow_coat_color1.95357716
14MP0000749_muscle_degeneration1.90238650
15MP0004215_abnormal_myocardial_fiber1.89751902
16MP0003122_maternal_imprinting1.86607763
17MP0003279_aneurysm1.83035545
18MP0010030_abnormal_orbit_morphology1.81877328
19MP0002108_abnormal_muscle_morphology1.81007897
20MP0004233_abnormal_muscle_weight1.79008500
21MP0000013_abnormal_adipose_tissue1.75878273
22MP0001299_abnormal_eye_distance/1.66646809
23MP0003950_abnormal_plasma_membrane1.66555403
24MP0004036_abnormal_muscle_relaxation1.65766513
25MP0004087_abnormal_muscle_fiber1.65366787
26MP0004859_abnormal_synaptic_plasticity1.64643026
27MP0004130_abnormal_muscle_cell1.58183158
28MP0003880_abnormal_central_pattern1.55955179
29MP0005330_cardiomyopathy1.49984690
30MP0009780_abnormal_chondrocyte_physiolo1.49877353
31MP0003385_abnormal_body_wall1.48763359
32MP0005620_abnormal_muscle_contractility1.46673267
33MP0005171_absent_coat_pigmentation1.43036474
34MP0009250_abnormal_appendicular_skeleto1.41127832
35MP0006138_congestive_heart_failure1.41016703
36MP0005670_abnormal_white_adipose1.37949204
37MP0000759_abnormal_skeletal_muscle1.37928017
38MP0005423_abnormal_somatic_nervous1.37686979
39MP0000747_muscle_weakness1.36587656
40MP0001293_anophthalmia1.35924287
41MP0001486_abnormal_startle_reflex1.32614426
42MP0003890_abnormal_embryonic-extraembry1.28818411
43MP0005666_abnormal_adipose_tissue1.28573723
44MP0001984_abnormal_olfaction1.28365064
45MP0000569_abnormal_digit_pigmentation1.25013807
46MP0004885_abnormal_endolymph1.24607653
47MP0000534_abnormal_ureter_morphology1.23486605
48MP0000003_abnormal_adipose_tissue1.23419804
49MP0002269_muscular_atrophy1.23013670
50MP0000733_abnormal_muscle_development1.22679682
51MP0003942_abnormal_urinary_system1.21851993
52MP0000537_abnormal_urethra_morphology1.21020899
53MP0002972_abnormal_cardiac_muscle1.19537994
54MP0005369_muscle_phenotype1.19266980
55MP0005187_abnormal_penis_morphology1.19179597
56MP0001879_abnormal_lymphatic_vessel1.18017753
57MP0009384_cardiac_valve_regurgitation1.17002571
58MP0003137_abnormal_impulse_conducting1.16737370
59MP0000955_abnormal_spinal_cord1.14866836
60MP0003119_abnormal_digestive_system1.14761661
61MP0002234_abnormal_pharynx_morphology1.14748162
62MP0000750_abnormal_muscle_regeneration1.13862141
63MP0005375_adipose_tissue_phenotype1.13679051
64MP0001958_emphysema1.13670346
65MP0010630_abnormal_cardiac_muscle1.13199546
66MP0002106_abnormal_muscle_physiology1.13140365
67MP0004185_abnormal_adipocyte_glucose1.12712284
68MP0004085_abnormal_heartbeat1.11842713
69MP0003283_abnormal_digestive_organ1.10772914
70MP0004133_heterotaxia1.10147784
71MP0006292_abnormal_olfactory_placode1.09166550
72MP0002638_abnormal_pupillary_reflex1.09011557
73MP0003861_abnormal_nervous_system1.07543754
74MP0003941_abnormal_skin_development1.07202763
75MP0002734_abnormal_mechanical_nocicepti1.06745564
76MP0003123_paternal_imprinting1.06721112
77MP0008775_abnormal_heart_ventricle1.06573635
78MP0004270_analgesia1.05982069
79MP0003121_genomic_imprinting1.05624230
80MP0002249_abnormal_larynx_morphology1.05562908
81MP0003937_abnormal_limbs/digits/tail_de1.04912508
82MP0003646_muscle_fatigue1.04789098
83MP0000428_abnormal_craniofacial_morphol1.03360188
84MP0003115_abnormal_respiratory_system1.01648110
85MP0003635_abnormal_synaptic_transmissio0.98841546
86MP0003935_abnormal_craniofacial_develop0.98286033
87MP0005508_abnormal_skeleton_morphology0.98265610
88MP0005248_abnormal_Harderian_gland0.97678704
89MP0005257_abnormal_intraocular_pressure0.97162890
90MP0009053_abnormal_anal_canal0.97000124
91MP0001286_abnormal_eye_development0.96622948
92MP0002102_abnormal_ear_morphology0.95528957
93MP0000631_abnormal_neuroendocrine_gland0.93465482
94MP0008789_abnormal_olfactory_epithelium0.92959675
95MP0005253_abnormal_eye_physiology0.92706414
96MP0002896_abnormal_bone_mineralization0.92518188
97MP0005385_cardiovascular_system_phenoty0.92146726
98MP0001544_abnormal_cardiovascular_syste0.92146726
99MP0002152_abnormal_brain_morphology0.91917714
100MP0005391_vision/eye_phenotype0.91110350
101MP0002092_abnormal_eye_morphology0.91075156
102MP0006276_abnormal_autonomic_nervous0.90882938
103MP0003567_abnormal_fetal_cardiomyocyte0.90360386
104MP0005551_abnormal_eye_electrophysiolog0.89717999
105MP0002932_abnormal_joint_morphology0.89184810
106MP0000432_abnormal_head_morphology0.89063708
107MP0003755_abnormal_palate_morphology0.88997208
108MP0000462_abnormal_digestive_system0.87903480
109MP0000778_abnormal_nervous_system0.87407667
110MP0004484_altered_response_of0.87121932
111MP0002882_abnormal_neuron_morphology0.86217992
112MP0003938_abnormal_ear_development0.85484772
113MP0002272_abnormal_nervous_system0.84458633
114MP0000762_abnormal_tongue_morphology0.83491353
115MP0001177_atelectasis0.83159747
116MP0000049_abnormal_middle_ear0.82334785
117MP0002572_abnormal_emotion/affect_behav0.80981438
118MP0001485_abnormal_pinna_reflex0.80865381
119MP0005377_hearing/vestibular/ear_phenot0.80730268
120MP0003878_abnormal_ear_physiology0.80730268
121MP0000026_abnormal_inner_ear0.80398710
122MP0002282_abnormal_trachea_morphology0.80090377
123MP0000579_abnormal_nail_morphology0.79772027
124MP0002752_abnormal_somatic_nervous0.79286036
125MP0003045_fibrosis0.76519638
126MP0002938_white_spotting0.76029449
127MP0004858_abnormal_nervous_system0.75318505
128MP0002184_abnormal_innervation0.74892322
129MP0002295_abnormal_pulmonary_circulatio0.73601269
130MP0004134_abnormal_chest_morphology0.73146818
131MP0000266_abnormal_heart_morphology0.72488139
132MP0006072_abnormal_retinal_apoptosis0.71212640
133MP0003828_pulmonary_edema0.71061102
134MP0002233_abnormal_nose_morphology0.69145100
135MP0002116_abnormal_craniofacial_bone0.67299246
136MP0002697_abnormal_eye_size0.66252987
137MP0000163_abnormal_cartilage_morphology0.65866298
138MP0002128_abnormal_blood_circulation0.65548370
139MP0002063_abnormal_learning/memory/cond0.64346635
140MP0002971_abnormal_brown_adipose0.64039049
141MP0005595_abnormal_vascular_smooth0.63547621
142MP0003091_abnormal_cell_migration0.63067250

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.88460348
2Broad metatarsal (HP:0001783)3.72826196
3Shallow orbits (HP:0000586)3.34884864
4Premature rupture of membranes (HP:0001788)3.28018477
5Type 1 muscle fiber predominance (HP:0003803)3.24452366
6Increased connective tissue (HP:0009025)3.05413524
7Cerebral aneurysm (HP:0004944)3.04135874
8Overgrowth (HP:0001548)2.99415796
9Difficulty running (HP:0009046)2.97804034
10Increased variability in muscle fiber diameter (HP:0003557)2.94080553
11Wrist flexion contracture (HP:0001239)2.92339724
12Muscle fiber splitting (HP:0003555)2.90983552
13Spinal rigidity (HP:0003306)2.88108767
14Hyporeflexia of lower limbs (HP:0002600)2.80839209
15Exercise-induced myalgia (HP:0003738)2.80066712
16Abnormality of the ischium (HP:0003174)2.77479445
17Abnormality of the calf musculature (HP:0001430)2.76150816
18Myotonia (HP:0002486)2.60855025
19Round ear (HP:0100830)2.58769957
20Sudden death (HP:0001699)2.54639083
21Ankle contracture (HP:0006466)2.50859535
22Abnormality of skeletal muscle fiber size (HP:0012084)2.45713841
23Exercise-induced muscle cramps (HP:0003710)2.40852097
24Aortic aneurysm (HP:0004942)2.40185233
25Aortic dissection (HP:0002647)2.36496536
26Short 4th metacarpal (HP:0010044)2.34787376
27Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.34787376
28Abnormality of the 4th metacarpal (HP:0010012)2.34492038
29Calf muscle hypertrophy (HP:0008981)2.33117305
30Muscle hypertrophy of the lower extremities (HP:0008968)2.32355186
31Bladder diverticulum (HP:0000015)2.30994111
32Cutaneous syndactyly (HP:0012725)2.27935618
33Lymphangioma (HP:0100764)2.27159207
34Central scotoma (HP:0000603)2.25563191
35Neonatal short-limb short stature (HP:0008921)2.23271907
36Scapular winging (HP:0003691)2.23177620
37Buphthalmos (HP:0000557)2.20904980
38Hip contracture (HP:0003273)2.18965279
39Mitral valve prolapse (HP:0001634)2.17863054
40Insidious onset (HP:0003587)2.15895238
41Termporal pattern (HP:0011008)2.15895238
42Mildly elevated creatine phosphokinase (HP:0008180)2.09670794
43Atrial fibrillation (HP:0005110)2.07948717
44EMG: myopathic abnormalities (HP:0003458)2.02894950
45Focal motor seizures (HP:0011153)2.01900433
46Abnormality of the lower motor neuron (HP:0002366)2.01494773
47Aneurysm (HP:0002617)2.01370461
48Lipoatrophy (HP:0100578)1.98977697
49Drooling (HP:0002307)1.98887111
50Coronal craniosynostosis (HP:0004440)1.96985046
51Preaxial foot polydactyly (HP:0001841)1.96964639
52Vitreoretinal degeneration (HP:0000655)1.94894297
53Primary atrial arrhythmia (HP:0001692)1.94214728
54Myoglobinuria (HP:0002913)1.90510804
55Bell-shaped thorax (HP:0001591)1.89910402
56Limited hip movement (HP:0008800)1.89289992
57Hyperventilation (HP:0002883)1.86717032
58Esophageal atresia (HP:0002032)1.86661594
59Dilatation of the ascending aorta (HP:0005111)1.86161410
60Soft skin (HP:0000977)1.85812270
61Bowel diverticulosis (HP:0005222)1.84735631
62Chorioretinal atrophy (HP:0000533)1.83204165
63Difficulty climbing stairs (HP:0003551)1.82740624
64Abnormality of the antihelix (HP:0009738)1.82019612
65Scotoma (HP:0000575)1.81066791
66Supraventricular arrhythmia (HP:0005115)1.80140676
67Broad ribs (HP:0000885)1.79831639
68Arterial tortuosity (HP:0005116)1.78305193
69Bifid tongue (HP:0010297)1.78120059
70Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.76167343
71Wide anterior fontanel (HP:0000260)1.76111714
72Macroorchidism (HP:0000053)1.76035251
73Muscle fiber inclusion bodies (HP:0100299)1.75600522
74Supraventricular tachycardia (HP:0004755)1.74584621
75Colon cancer (HP:0003003)1.74115742
76Turricephaly (HP:0000262)1.73440840
77Flat cornea (HP:0007720)1.73209046
78Calcaneovalgus deformity (HP:0001848)1.72505414
79Astrocytoma (HP:0009592)1.71982702
80Abnormality of the astrocytes (HP:0100707)1.71982702
81Limb-girdle muscle weakness (HP:0003325)1.71441453
82Follicular hyperkeratosis (HP:0007502)1.70491056
83Action tremor (HP:0002345)1.70080728
84Vertebral arch anomaly (HP:0008438)1.70056327
85Midline defect of the nose (HP:0004122)1.70023673
86Bronchomalacia (HP:0002780)1.69870938
87Neoplasm of the oral cavity (HP:0100649)1.69479380
88Prolonged QT interval (HP:0001657)1.69461333
89Infantile muscular hypotonia (HP:0008947)1.69297295
90Enlarged penis (HP:0000040)1.68523535
91Megalencephaly (HP:0001355)1.68160824
92Papillary thyroid carcinoma (HP:0002895)1.68130967
93Hyperextensible skin (HP:0000974)1.67230266
94Abnormality of dentin (HP:0010299)1.66761740
95Excessive salivation (HP:0003781)1.66437192
96Pheochromocytoma (HP:0002666)1.66435551
97Focal seizures (HP:0007359)1.66260159
98Slender build (HP:0001533)1.66082947
99Morphological abnormality of the middle ear (HP:0008609)1.63925114
100Right ventricular cardiomyopathy (HP:0011663)1.63656853
101Wormian bones (HP:0002645)1.63225908
102Hammertoe (HP:0001765)1.63169732
103Aplasia/Hypoplasia of the sternum (HP:0006714)1.62711573
104Gastrointestinal atresia (HP:0002589)1.62520357
105Alacrima (HP:0000522)1.62518757
106Renal hypoplasia (HP:0000089)1.62397236
107Renal duplication (HP:0000075)1.61984268
108Anophthalmia (HP:0000528)1.60581389
109Fibular hypoplasia (HP:0003038)1.59661174
110Vascular tortuosity (HP:0004948)1.59244316
111Subaortic stenosis (HP:0001682)1.59213070
112Abnormality of the left ventricular outflow tract (HP:0011103)1.59213070
113Hepatoblastoma (HP:0002884)1.58919210
114Striae distensae (HP:0001065)1.58846869
115Intestinal atresia (HP:0011100)1.57886897
116Cutaneous finger syndactyly (HP:0010554)1.57791631
117Hypoplasia of the iris (HP:0007676)1.57459467
118Aqueductal stenosis (HP:0002410)1.56472781
119Deformed tarsal bones (HP:0008119)1.56351135
120Omphalocele (HP:0001539)1.56139451
121Hypoplastic ischia (HP:0003175)1.55664962
122Atrophic scars (HP:0001075)1.55422695
123Abnormality of the diencephalon (HP:0010662)1.54661117
124Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.54535928
125Septo-optic dysplasia (HP:0100842)1.53213410
126Partial duplication of thumb phalanx (HP:0009944)1.53129277
127Venous insufficiency (HP:0005293)1.52618796
128Venous abnormality (HP:0002624)1.52006461
129Bundle branch block (HP:0011710)1.51386428
130Camptodactyly of toe (HP:0001836)1.51065586
131Glioma (HP:0009733)1.50748854
132Hypoventilation (HP:0002791)1.49995465
133Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.49782908
134Aplasia involving bones of the extremities (HP:0009825)1.49565692
135Aplasia involving bones of the upper limbs (HP:0009823)1.49565692
136Aplasia of the phalanges of the hand (HP:0009802)1.49565692
137Renovascular hypertension (HP:0100817)1.49102996
138Blue sclerae (HP:0000592)1.48788869
139Broad long bones (HP:0005622)1.48444889
140Atonic seizures (HP:0010819)1.48092529
141Abnormality of the labia minora (HP:0012880)1.47984854
142Decreased lacrimation (HP:0000633)1.47930195
143Skull defect (HP:0001362)1.47689062
144Thin ribs (HP:0000883)1.47628689
145Partial duplication of the phalanx of hand (HP:0009999)1.47523112
146Ventricular tachycardia (HP:0004756)1.46558246
147Genital tract atresia (HP:0001827)1.45411098
148Occipital encephalocele (HP:0002085)1.45130362
149Abnormality of the middle phalanges of the toes (HP:0010183)1.44685316
150High anterior hairline (HP:0009890)1.44240146
151Vaginal atresia (HP:0000148)1.43841174
152Trigonocephaly (HP:0000243)1.43831774
153Hemiparesis (HP:0001269)1.43008429
154Oligodactyly (hands) (HP:0001180)1.42581487
155Tubulointerstitial nephritis (HP:0001970)1.41149622
156Broad phalanx (HP:0006009)1.41052510
157Bifid scrotum (HP:0000048)1.38636816
158Aplasia/Hypoplasia of the fibula (HP:0006492)1.36118389
159True hermaphroditism (HP:0010459)1.34312470

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.18102016
2TTN3.08153298
3LATS12.97914961
4LATS22.43696747
5PDGFRA2.36211687
6TIE12.27672943
7DDR22.24759274
8TRIB32.21451585
9OBSCN2.13240504
10TNIK2.13187237
11SIK12.03429520
12BMPR1B1.94448776
13PRKD31.91838987
14NTRK31.91824623
15CAMK1G1.86825831
16PHKG11.82656218
17PHKG21.82656218
18CAMK1D1.77559432
19PAK61.76520584
20FGFR21.72769007
21DMPK1.72727560
22EPHB21.71042088
23RIPK11.67357539
24MAP3K41.63216988
25PKN21.61601296
26SCYL21.61020102
27WNK31.46476579
28LMTK21.43143243
29PAK31.41417865
30NTRK11.39209829
31KSR11.36263983
32FER1.31677725
33MAPK151.24111428
34MKNK21.23445003
35KSR21.20871792
36MAP2K41.19047017
37AKT31.18333992
38EPHA41.12732191
39PTK2B1.11598548
40PIK3CA1.10575872
41INSRR1.09660821
42MUSK1.08247109
43WNK11.08107608
44RET1.07197994
45NEK91.00662408
46MET1.00022340
47MAPK130.99993893
48PDK30.99061654
49PDK40.99061654
50MKNK10.98594266
51WEE10.98372574
52PINK10.96825646
53STK380.95870461
54STK38L0.95811407
55ROCK10.94303671
56TSSK60.93267916
57FRK0.92421324
58PRKCH0.91431499
59MINK10.91258473
60FGFR10.87723829
61PLK20.87409126
62PDGFRB0.84996651
63BRSK20.83923311
64MTOR0.80812180
65STK390.79134737
66PAK20.78693074
67PTK20.78393933
68ICK0.78219872
69EPHA30.78136860
70MAP3K90.76963448
71BRD40.76955127
72PTK60.75458515
73NEK10.75195451
74EEF2K0.74459003
75MAP3K70.72718771
76BCR0.71875450
77PRKD10.71574667
78ROCK20.70766258
79CDC42BPA0.69564352
80NTRK20.69431818
81MAP2K70.68209069
82BMX0.68161307
83DYRK20.67348570
84MARK10.67201259
85SGK4940.65800756
86SGK2230.65800756
87CAMK2D0.65691881
88ERBB20.65335266
89PRKCG0.65161532
90CAMK10.63848697
91NLK0.63253937
92MAP3K20.62472079
93TGFBR10.62229821
94TYRO30.61996226
95PRKAA10.60938590
96PLK30.60671207
97PLK40.60329482
98CDK30.60019650
99CAMKK10.58095468
100MAP2K10.57967712
101CAMK2B0.57903302
102CAMK2A0.57708937
103WNK40.56613003
104DYRK1A0.56280996
105SGK30.55982175
106CDK50.55916139
107STK30.55744895
108PRKAA20.54361451
109PNCK0.53067625
110TTK0.53003837
111UHMK10.51640830
112PRKCE0.50771080
113CSNK1G30.50509846
114STK110.49816365
115MYLK0.47613510
116MAPKAPK50.47362481
117ERBB40.47169663
118ERBB30.46691173
119PRKDC0.45797561
120CSNK1G20.44964660
121SGK20.44775130
122RPS6KA30.44573397
123PRKACB0.43424747
124SGK10.43360684
125CSNK1A1L0.43337841
126SIK20.40464638
127MAPK100.39077253
128MARK20.38588984
129DAPK20.38586222
130CSNK1G10.38156466
131PKN10.38057223

Predicted pathways (KEGG)

RankGene SetZ-score
1Dilated cardiomyopathy_Homo sapiens_hsa054142.12477575
2Nitrogen metabolism_Homo sapiens_hsa009101.95287392
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.93104732
4ECM-receptor interaction_Homo sapiens_hsa045121.92180902
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.89583607
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.86277115
7Propanoate metabolism_Homo sapiens_hsa006401.71558555
8Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.67891777
9Butanoate metabolism_Homo sapiens_hsa006501.51206295
10Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.49223922
11Fatty acid metabolism_Homo sapiens_hsa012121.44439770
12Focal adhesion_Homo sapiens_hsa045101.43450378
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.41502196
14Circadian entrainment_Homo sapiens_hsa047131.39856638
15GABAergic synapse_Homo sapiens_hsa047271.34770325
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.33478874
17Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.31991747
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.26873336
19Cardiac muscle contraction_Homo sapiens_hsa042601.25838303
20Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.25283590
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.23874704
22Fatty acid degradation_Homo sapiens_hsa000711.23705664
23Phototransduction_Homo sapiens_hsa047441.23182498
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.22120843
25PPAR signaling pathway_Homo sapiens_hsa033201.22115518
26Renin secretion_Homo sapiens_hsa049241.19409318
27Axon guidance_Homo sapiens_hsa043601.19403192
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.18731732
29cGMP-PKG signaling pathway_Homo sapiens_hsa040221.15869358
30Insulin secretion_Homo sapiens_hsa049111.15458451
31beta-Alanine metabolism_Homo sapiens_hsa004101.14916428
32Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.14569718
33Nicotine addiction_Homo sapiens_hsa050331.13996626
34Oxytocin signaling pathway_Homo sapiens_hsa049211.12919756
35Aldosterone synthesis and secretion_Homo sapiens_hsa049251.12342234
36Fatty acid biosynthesis_Homo sapiens_hsa000611.11568478
37Histidine metabolism_Homo sapiens_hsa003401.11414511
38Glucagon signaling pathway_Homo sapiens_hsa049221.11299869
39Basal cell carcinoma_Homo sapiens_hsa052171.11003676
40Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.09518156
41Glutamatergic synapse_Homo sapiens_hsa047241.08431667
42Melanogenesis_Homo sapiens_hsa049161.06389597
43Long-term potentiation_Homo sapiens_hsa047201.06222719
44Type II diabetes mellitus_Homo sapiens_hsa049301.02842674
45Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.02557371
46Adherens junction_Homo sapiens_hsa045201.02262991
47Arginine biosynthesis_Homo sapiens_hsa002201.01480536
48Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.01257201
49Dopaminergic synapse_Homo sapiens_hsa047281.01121753
50Proteoglycans in cancer_Homo sapiens_hsa052051.00990109
51Hedgehog signaling pathway_Homo sapiens_hsa043401.00686269
52Dorso-ventral axis formation_Homo sapiens_hsa043201.00515104
53Hippo signaling pathway_Homo sapiens_hsa043900.99711782
54Lysine degradation_Homo sapiens_hsa003100.99246629
55AMPK signaling pathway_Homo sapiens_hsa041520.99019581
56Cholinergic synapse_Homo sapiens_hsa047250.98517878
57Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.98103062
58Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.98049639
59Gap junction_Homo sapiens_hsa045400.97792559
60Salivary secretion_Homo sapiens_hsa049700.97295603
61Glioma_Homo sapiens_hsa052140.96497899
62Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.96453596
63GnRH signaling pathway_Homo sapiens_hsa049120.96171845
64Vascular smooth muscle contraction_Homo sapiens_hsa042700.96120380
65Steroid biosynthesis_Homo sapiens_hsa001000.94835993
66Gastric acid secretion_Homo sapiens_hsa049710.94386542
67Morphine addiction_Homo sapiens_hsa050320.94183808
68Insulin signaling pathway_Homo sapiens_hsa049100.93832224
69* Tight junction_Homo sapiens_hsa045300.91277638
70Amphetamine addiction_Homo sapiens_hsa050310.90729444
71Long-term depression_Homo sapiens_hsa047300.89975241
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.88718842
73cAMP signaling pathway_Homo sapiens_hsa040240.88448383
74Estrogen signaling pathway_Homo sapiens_hsa049150.87584782
75Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.86405894
76Pyruvate metabolism_Homo sapiens_hsa006200.86390124
77Synaptic vesicle cycle_Homo sapiens_hsa047210.86183885
78Arginine and proline metabolism_Homo sapiens_hsa003300.85960870
79Bile secretion_Homo sapiens_hsa049760.84245611
80Calcium signaling pathway_Homo sapiens_hsa040200.83567840
81Retinol metabolism_Homo sapiens_hsa008300.82961951
82Ovarian steroidogenesis_Homo sapiens_hsa049130.82948184
83Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.82686540
84Insulin resistance_Homo sapiens_hsa049310.81682533
85Central carbon metabolism in cancer_Homo sapiens_hsa052300.81075680
86Cocaine addiction_Homo sapiens_hsa050300.79125945
87Phenylalanine metabolism_Homo sapiens_hsa003600.78060812
88Amoebiasis_Homo sapiens_hsa051460.76323770
89Olfactory transduction_Homo sapiens_hsa047400.75924438
90Longevity regulating pathway - mammal_Homo sapiens_hsa042110.75322474
91mTOR signaling pathway_Homo sapiens_hsa041500.75119340
92Circadian rhythm_Homo sapiens_hsa047100.75071419
93Protein digestion and absorption_Homo sapiens_hsa049740.74356671
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.74052698
95Carbon metabolism_Homo sapiens_hsa012000.73829328
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73556622
97Wnt signaling pathway_Homo sapiens_hsa043100.73272381
98Complement and coagulation cascades_Homo sapiens_hsa046100.72284151
99TGF-beta signaling pathway_Homo sapiens_hsa043500.72050438
100MicroRNAs in cancer_Homo sapiens_hsa052060.72050354
101Tyrosine metabolism_Homo sapiens_hsa003500.71659930
102Renal cell carcinoma_Homo sapiens_hsa052110.71650123
103Tryptophan metabolism_Homo sapiens_hsa003800.71468336
104Primary bile acid biosynthesis_Homo sapiens_hsa001200.69055587
105Thyroid hormone synthesis_Homo sapiens_hsa049180.64920307
106Rap1 signaling pathway_Homo sapiens_hsa040150.64722700
107Melanoma_Homo sapiens_hsa052180.64088752
108Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.63973228
109ErbB signaling pathway_Homo sapiens_hsa040120.62759653
110Colorectal cancer_Homo sapiens_hsa052100.61538913
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.60652124
112Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.59808469
113Taste transduction_Homo sapiens_hsa047420.58688338
114ABC transporters_Homo sapiens_hsa020100.58542839
115Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58295330
116Serotonergic synapse_Homo sapiens_hsa047260.57659147
117Fatty acid elongation_Homo sapiens_hsa000620.56970602
118Endometrial cancer_Homo sapiens_hsa052130.56861790
119Oocyte meiosis_Homo sapiens_hsa041140.56718468
120Vitamin B6 metabolism_Homo sapiens_hsa007500.55014863
121PI3K-Akt signaling pathway_Homo sapiens_hsa041510.54664644
122Chemical carcinogenesis_Homo sapiens_hsa052040.53812341
123Caffeine metabolism_Homo sapiens_hsa002320.53611199
124Steroid hormone biosynthesis_Homo sapiens_hsa001400.53359907

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