MPC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is part of an MPC1/MPC2 heterodimer that is responsible for transporting pyruvate into mitochondria. The encoded protein is found in the inner mitochondrial membrane. Defects in this gene are a cause of mitochondrial pyruvate carrier deficiency. Several transcript variants, some protein coding and one non-protein coding, have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)5.90714731
2central nervous system myelination (GO:0022010)5.90714731
3fatty acid elongation (GO:0030497)5.78808776
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.23663877
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.80313198
6respiratory electron transport chain (GO:0022904)4.55447594
7energy coupled proton transport, down electrochemical gradient (GO:0015985)4.46298299
8ATP synthesis coupled proton transport (GO:0015986)4.46298299
9electron transport chain (GO:0022900)4.42750251
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.38392554
11L-phenylalanine catabolic process (GO:0006559)4.38392554
12regulation of relaxation of muscle (GO:1901077)4.34834417
13muscle filament sliding (GO:0030049)4.26939042
14actin-myosin filament sliding (GO:0033275)4.26939042
15regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.26315000
16regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.16335248
17regulation of cell communication by electrical coupling (GO:0010649)4.06848377
18positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.96926470
19erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.92328535
20L-phenylalanine metabolic process (GO:0006558)3.92328535
21regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.89943149
22regulation of cholesterol esterification (GO:0010872)3.88507221
23long-chain fatty acid biosynthetic process (GO:0042759)3.82105620
24oxaloacetate metabolic process (GO:0006107)3.80850223
25cholesterol biosynthetic process (GO:0006695)3.78024919
26thioester biosynthetic process (GO:0035384)3.77609727
27acyl-CoA biosynthetic process (GO:0071616)3.77609727
28regulation of actin filament-based movement (GO:1903115)3.73326210
29long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.71725230
30fatty-acyl-CoA biosynthetic process (GO:0046949)3.69406544
31fatty-acyl-CoA metabolic process (GO:0035337)3.68229733
32high-density lipoprotein particle remodeling (GO:0034375)3.56561789
33cardiac muscle contraction (GO:0060048)3.52764366
34cellular ketone body metabolic process (GO:0046950)3.51811776
35creatine metabolic process (GO:0006600)3.51399016
36long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.50142421
37sarcoplasmic reticulum calcium ion transport (GO:0070296)3.48640433
38acetyl-CoA metabolic process (GO:0006084)3.48413822
39protein-lipid complex remodeling (GO:0034368)3.43018484
40macromolecular complex remodeling (GO:0034367)3.43018484
41plasma lipoprotein particle remodeling (GO:0034369)3.43018484
42very long-chain fatty acid metabolic process (GO:0000038)3.42026726
43thioester metabolic process (GO:0035383)3.39814827
44acyl-CoA metabolic process (GO:0006637)3.39814827
45oxidative phosphorylation (GO:0006119)3.39189610
46actin-mediated cell contraction (GO:0070252)3.38009539
47heart contraction (GO:0060047)3.37615193
48heart process (GO:0003015)3.37615193
49regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.36069142
50chaperone-mediated protein transport (GO:0072321)3.35926991
51phospholipid homeostasis (GO:0055091)3.32550257
52sterol biosynthetic process (GO:0016126)3.31096403
53response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.30717719
54aromatic amino acid family catabolic process (GO:0009074)3.30604439
55reverse cholesterol transport (GO:0043691)3.29633227
56aldehyde catabolic process (GO:0046185)3.27131328
57striated muscle contraction (GO:0006941)3.26198313
58cofactor catabolic process (GO:0051187)3.23767200
59short-chain fatty acid metabolic process (GO:0046459)3.23188723
60protein neddylation (GO:0045116)3.13804092
61myelination (GO:0042552)3.12886312
62ensheathment of neurons (GO:0007272)3.12253278
63axon ensheathment (GO:0008366)3.12253278
64negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.11771100
65myofibril assembly (GO:0030239)3.08801057
66aspartate family amino acid catabolic process (GO:0009068)3.07937917
67ketone body metabolic process (GO:1902224)3.07716168
68sarcomere organization (GO:0045214)3.07689610
69response to methylmercury (GO:0051597)3.05857635
70glyoxylate metabolic process (GO:0046487)3.03203352
71regulation of protein activation cascade (GO:2000257)3.02446205
72coenzyme catabolic process (GO:0009109)3.00742929
73branched-chain amino acid catabolic process (GO:0009083)3.00407565
74blood coagulation, intrinsic pathway (GO:0007597)3.00225671
75cardiac myofibril assembly (GO:0055003)2.99385778
76amino acid salvage (GO:0043102)2.94764327
77L-methionine salvage (GO:0071267)2.94764327
78L-methionine biosynthetic process (GO:0071265)2.94764327
79substantia nigra development (GO:0021762)2.93909644
80negative regulation of protein localization to cell surface (GO:2000009)2.93850876
81fatty acid beta-oxidation (GO:0006635)2.91360972
82ubiquinone biosynthetic process (GO:0006744)2.90898689
83fatty acid catabolic process (GO:0009062)2.90290054
84L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.89968621
85detection of calcium ion (GO:0005513)2.88888467
86acylglycerol homeostasis (GO:0055090)2.88450133
87triglyceride homeostasis (GO:0070328)2.88450133
88glycerophospholipid catabolic process (GO:0046475)2.87701913
89regulation of complement activation (GO:0030449)2.85670112
90regulation of skeletal muscle contraction (GO:0014819)2.83959763
91response to redox state (GO:0051775)2.83774571
92quinone biosynthetic process (GO:1901663)2.81857169
93glutathione biosynthetic process (GO:0006750)2.79562011
94isoprenoid biosynthetic process (GO:0008299)2.79088105
95mitochondrial respiratory chain complex assembly (GO:0033108)2.79078429
96hydrogen ion transmembrane transport (GO:1902600)2.78899657
97negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.77931541
98negative regulation of calcium ion transmembrane transport (GO:1903170)2.77931541
99fatty acid transmembrane transport (GO:1902001)2.77061001
100bile acid biosynthetic process (GO:0006699)2.76780223
101cardiac muscle hypertrophy (GO:0003300)2.75830955
102regulation of striated muscle contraction (GO:0006942)2.74572167
103positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.74541913
104tricarboxylic acid cycle (GO:0006099)2.74197762
105membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.72354896
106alpha-linolenic acid metabolic process (GO:0036109)2.70783446
107heme transport (GO:0015886)2.70451746
108cholesterol efflux (GO:0033344)2.70366867
109establishment of protein localization to mitochondrial membrane (GO:0090151)2.69237074
110regulation of cardiac muscle cell contraction (GO:0086004)2.67603504
111proton transport (GO:0015992)2.66697214
112amyloid precursor protein metabolic process (GO:0042982)2.66460335
113low-density lipoprotein particle remodeling (GO:0034374)2.65636884
114hydrogen transport (GO:0006818)2.65523913
115fatty acid oxidation (GO:0019395)2.65018627
116lipid oxidation (GO:0034440)2.64799662
117monocarboxylic acid catabolic process (GO:0072329)2.64623164
118nonribosomal peptide biosynthetic process (GO:0019184)2.64494538
119complement activation, alternative pathway (GO:0006957)2.64040977
120gluconeogenesis (GO:0006094)2.63859911
121striated muscle hypertrophy (GO:0014897)2.63256336
122regulation of lipoprotein metabolic process (GO:0050746)2.62730968
123cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.62553635
124NADH metabolic process (GO:0006734)2.62518359
125peroxisome fission (GO:0016559)2.62389496
126presynaptic membrane organization (GO:0097090)2.62140259
127skeletal muscle contraction (GO:0003009)2.61883657
1282-oxoglutarate metabolic process (GO:0006103)2.61180262
129triglyceride biosynthetic process (GO:0019432)2.60824651
130plasma lipoprotein particle clearance (GO:0034381)2.60024602
131succinate metabolic process (GO:0006105)2.59842191
132ubiquinone metabolic process (GO:0006743)2.59049285
133ATP biosynthetic process (GO:0006754)2.58621456
134phospholipid efflux (GO:0033700)2.58417646
135cysteine metabolic process (GO:0006534)2.58176650
136dicarboxylic acid catabolic process (GO:0043649)2.57212328
137branched-chain amino acid metabolic process (GO:0009081)2.55207071
138fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.53879580
139mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.53347801
140mitochondrial respiratory chain complex I assembly (GO:0032981)2.53347801
141NADH dehydrogenase complex assembly (GO:0010257)2.53347801
142biotin metabolic process (GO:0006768)2.53192043
143acylglycerol biosynthetic process (GO:0046463)2.52613021
144neutral lipid biosynthetic process (GO:0046460)2.52613021
145glutathione derivative biosynthetic process (GO:1901687)2.52364924
146glutathione derivative metabolic process (GO:1901685)2.52364924
147ATP hydrolysis coupled proton transport (GO:0015991)2.51036196
148energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.51036196
149positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.47970412
150protein complex biogenesis (GO:0070271)2.47629765
151glutathione metabolic process (GO:0006749)2.47395649
152myelin maintenance (GO:0043217)2.46728847
153regulation of sequestering of triglyceride (GO:0010889)2.46609955
154negative regulation of neurotransmitter transport (GO:0051589)2.46126643
155amyloid precursor protein catabolic process (GO:0042987)2.44819912
156regulation of triglyceride catabolic process (GO:0010896)2.44558953
157tyrosine metabolic process (GO:0006570)2.44402534
158regulation of acyl-CoA biosynthetic process (GO:0050812)2.43186799
159regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.42659904
160aromatic amino acid family metabolic process (GO:0009072)2.42402757
161establishment of mitochondrion localization (GO:0051654)2.41982673
162triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.40562199
163positive regulation of cellular amine metabolic process (GO:0033240)2.39806767
164nucleotide transmembrane transport (GO:1901679)2.39602808

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.87454329
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.30580189
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.23029338
4GBX2_23144817_ChIP-Seq_PC3_Human2.77185216
5RXR_22158963_ChIP-Seq_LIVER_Mouse2.63567092
6EGR1_23403033_ChIP-Seq_LIVER_Mouse2.38407266
7TAF15_26573619_Chip-Seq_HEK293_Human2.36828516
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.27779862
9LXR_22158963_ChIP-Seq_LIVER_Mouse2.22805055
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.21539202
11PPARA_22158963_ChIP-Seq_LIVER_Mouse1.96031429
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.93465337
13VDR_22108803_ChIP-Seq_LS180_Human1.92882348
14SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.91279967
15GABP_17652178_ChIP-ChIP_JURKAT_Human1.89768416
16ZFP57_27257070_Chip-Seq_ESCs_Mouse1.88308766
17CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.87073541
18IGF1R_20145208_ChIP-Seq_DFB_Human1.85803919
19HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.84363087
20FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.83809513
21BP1_19119308_ChIP-ChIP_Hs578T_Human1.78039861
22PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.76587253
23SRF_21415370_ChIP-Seq_HL-1_Mouse1.73569919
24ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.69263007
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65968312
26HTT_18923047_ChIP-ChIP_STHdh_Human1.62098163
27SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.60511270
28ER_23166858_ChIP-Seq_MCF-7_Human1.59186363
29SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.58141368
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.57644700
31PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.55867765
32POU3F2_20337985_ChIP-ChIP_501MEL_Human1.55516906
33JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.52362572
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.49044399
35CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.45838306
36OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43107124
37NRF2_20460467_ChIP-Seq_MEFs_Mouse1.42191159
38NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.42191159
39CREB1_15753290_ChIP-ChIP_HEK293T_Human1.38196931
40PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.37669871
41EZH2_27294783_Chip-Seq_NPCs_Mouse1.36694356
42MTF2_20144788_ChIP-Seq_MESCs_Mouse1.34666806
43SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.33097981
44TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32685529
45EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.31498300
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.30069519
47SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.28430539
48JARID2_20064375_ChIP-Seq_MESCs_Mouse1.25942139
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.24868408
50EZH2_22144423_ChIP-Seq_EOC_Human1.24802265
51P300_19829295_ChIP-Seq_ESCs_Human1.24247416
52SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.22776178
53PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20229407
54CTBP2_25329375_ChIP-Seq_LNCAP_Human1.18573474
55EST1_17652178_ChIP-ChIP_JURKAT_Human1.18452083
56CRX_20693478_ChIP-Seq_RETINA_Mouse1.17735965
57CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.15873248
58NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.14558001
59SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.12728249
60UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11980132
61LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.11246484
62GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.11233941
63PHF8_20622853_ChIP-Seq_HELA_Human1.10553785
64EZH2_27304074_Chip-Seq_ESCs_Mouse1.09848590
65NFE2_27457419_Chip-Seq_LIVER_Mouse1.09639337
66RNF2_18974828_ChIP-Seq_MESCs_Mouse1.08496852
67EZH2_18974828_ChIP-Seq_MESCs_Mouse1.08496852
68EED_16625203_ChIP-ChIP_MESCs_Mouse1.08434037
69SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.07110672
70ETS1_20019798_ChIP-Seq_JURKAT_Human1.06977502
71IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.05626755
72CBP_20019798_ChIP-Seq_JUKART_Human1.05626755
73STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.05080239
74BCAT_22108803_ChIP-Seq_LS180_Human1.05070588
75KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04491616
76NANOG_19829295_ChIP-Seq_ESCs_Human1.03978504
77SOX2_19829295_ChIP-Seq_ESCs_Human1.03978504
78RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.03373241
79CDX2_22108803_ChIP-Seq_LS180_Human1.03063650
80CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.02848167
81JARID2_20075857_ChIP-Seq_MESCs_Mouse1.01406837
82MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.01062591
83PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.00325456
84SMAD3_21741376_ChIP-Seq_EPCs_Human0.99608240
85SUZ12_27294783_Chip-Seq_ESCs_Mouse0.99580291
86EZH2_27294783_Chip-Seq_ESCs_Mouse0.97978709
87NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.97728772
88TAL1_26923725_Chip-Seq_HPCs_Mouse0.96742329
89OCT4_21477851_ChIP-Seq_ESCs_Mouse0.96322463
90GATA1_22025678_ChIP-Seq_K562_Human0.96310203
91SALL4_22934838_ChIP-ChIP_CD34+_Human0.95400462
92AR_21572438_ChIP-Seq_LNCaP_Human0.95372671
93NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.95185295
94TOP2B_26459242_ChIP-Seq_MCF-7_Human0.95155533
95BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.94478774
96VDR_23849224_ChIP-Seq_CD4+_Human0.94220282
97CBX2_27304074_Chip-Seq_ESCs_Mouse0.93497768
98FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.92497240
99SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.91991898
100TP53_22573176_ChIP-Seq_HFKS_Human0.91913380
101PCGF2_27294783_Chip-Seq_ESCs_Mouse0.91790987
102FLI1_27457419_Chip-Seq_LIVER_Mouse0.91752506
103EP300_21415370_ChIP-Seq_HL-1_Mouse0.91649245
104CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.91615929
105BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.91411139
106GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.91229123
107NR3C1_23031785_ChIP-Seq_PC12_Mouse0.90372805
108CBP_21632823_ChIP-Seq_H3396_Human0.90273394
109GATA6_21074721_ChIP-Seq_CACO-2_Human0.89862507
110EOMES_21245162_ChIP-Seq_HESCs_Human0.89459720
111ZNF274_21170338_ChIP-Seq_K562_Hela0.89121974
112HNFA_21074721_ChIP-Seq_CACO-2_Human0.89080693
113PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.89060486
114SUZ12_18555785_Chip-Seq_ESCs_Mouse0.89053407
115PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.88421932
116SMAD4_21799915_ChIP-Seq_A2780_Human0.88299381
117CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.87806644
118REST_21632747_ChIP-Seq_MESCs_Mouse0.87337857
119TCF4_22108803_ChIP-Seq_LS180_Human0.87280714
120RBPJ_21746931_ChIP-Seq_IB4_Human0.86432726
121RUNX1_27457419_Chip-Seq_LIVER_Mouse0.86120954
122CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.86000343
123AR_20517297_ChIP-Seq_VCAP_Human0.85966654
124NANOG_18555785_Chip-Seq_ESCs_Mouse0.85143321
125AUTS2_25519132_ChIP-Seq_293T-REX_Human0.85082701
126RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84615868
127CMYC_18555785_Chip-Seq_ESCs_Mouse0.84417174
128STAT3_18555785_Chip-Seq_ESCs_Mouse0.82942727
129BMI1_23680149_ChIP-Seq_NPCS_Mouse0.82917480
130EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.82850506
131PRDM14_20953172_ChIP-Seq_ESCs_Human0.82672673
132EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.81767079
133PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.81236556
134KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.81214917
135SMAD1_18555785_Chip-Seq_ESCs_Mouse0.81092062
136PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.81004725
137REST_18959480_ChIP-ChIP_MESCs_Mouse0.80674675
138NCOR_22424771_ChIP-Seq_293T_Human0.80614116
139P53_22387025_ChIP-Seq_ESCs_Mouse0.80479756
140P300_18555785_Chip-Seq_ESCs_Mouse0.80216287
141SOX2_18555785_Chip-Seq_ESCs_Mouse0.80193556
142Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.80186146
143SUZ12_27294783_Chip-Seq_NPCs_Mouse0.80058178
144TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79133249
145AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.79116928

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system3.47854699
2MP0003806_abnormal_nucleotide_metabolis3.28352409
3MP0005360_urolithiasis3.08785149
4MP0000920_abnormal_myelination3.07884439
5MP0003195_calcinosis2.92455106
6MP0004084_abnormal_cardiac_muscle2.82076978
7MP0005085_abnormal_gallbladder_physiolo2.65527228
8MP0003880_abnormal_central_pattern2.63498684
9MP0008875_abnormal_xenobiotic_pharmacok2.61833717
10MP0002837_dystrophic_cardiac_calcinosis2.53845087
11MP0005365_abnormal_bile_salt2.34551474
12MP0003690_abnormal_glial_cell2.28417000
13MP0001529_abnormal_vocalization2.24437189
14MP0004043_abnormal_pH_regulation2.13967847
15MP0003329_amyloid_beta_deposits2.12386895
16MP0005332_abnormal_amino_acid2.08957888
17MP0005451_abnormal_body_composition2.08610643
18MP0004484_altered_response_of2.01533302
19MP0006036_abnormal_mitochondrial_physio1.97994793
20MP0001905_abnormal_dopamine_level1.94220250
21MP0003646_muscle_fatigue1.88526435
22MP0009840_abnormal_foam_cell1.84845856
23MP0003950_abnormal_plasma_membrane1.83528844
24MP0004270_analgesia1.79719586
25MP0002638_abnormal_pupillary_reflex1.76033325
26MP0004142_abnormal_muscle_tone1.75629251
27MP0002272_abnormal_nervous_system1.71306168
28MP0003186_abnormal_redox_activity1.69142351
29MP0003137_abnormal_impulse_conducting1.64833595
30MP0009046_muscle_twitch1.63764107
31MP0008260_abnormal_autophagy1.63487067
32MP0000604_amyloidosis1.60364192
33MP0002064_seizures1.59964246
34MP0008775_abnormal_heart_ventricle1.57121699
35MP0002118_abnormal_lipid_homeostasis1.55403376
36MP0002269_muscular_atrophy1.55311522
37MP0004147_increased_porphyrin_level1.55085031
38MP0004130_abnormal_muscle_cell1.53023142
39MP0002106_abnormal_muscle_physiology1.51468519
40MP0004036_abnormal_muscle_relaxation1.50452929
41MP0001544_abnormal_cardiovascular_syste1.49634840
42MP0005385_cardiovascular_system_phenoty1.49634840
43MP0005646_abnormal_pituitary_gland1.47217239
44MP0003656_abnormal_erythrocyte_physiolo1.47045924
45MP0010329_abnormal_lipoprotein_level1.47003828
46MP0004087_abnormal_muscle_fiber1.44455192
47MP0005584_abnormal_enzyme/coenzyme_acti1.44393666
48MP0005171_absent_coat_pigmentation1.41679878
49MP0005083_abnormal_biliary_tract1.40683486
50MP0001486_abnormal_startle_reflex1.38420775
51MP0002876_abnormal_thyroid_physiology1.37887305
52MP0001661_extended_life_span1.36897648
53MP0005535_abnormal_body_temperature1.34946806
54MP0009745_abnormal_behavioral_response1.34392067
55MP0003191_abnormal_cellular_cholesterol1.31961081
56MP0004742_abnormal_vestibular_system1.29959573
57MP0002127_abnormal_cardiovascular_syste1.29103321
58MP0000749_muscle_degeneration1.29025771
59MP0001440_abnormal_grooming_behavior1.25548505
60MP0004085_abnormal_heartbeat1.24778757
61MP0003136_yellow_coat_color1.24006381
62MP0003634_abnormal_glial_cell1.21567641
63MP0005369_muscle_phenotype1.21512865
64MP0002822_catalepsy1.21387952
65MP0002229_neurodegeneration1.19268223
66MP0004510_myositis1.19094313
67MP0003868_abnormal_feces_composition1.18509721
68MP0005058_abnormal_lysosome_morphology1.18163384
69MP0000751_myopathy1.15721796
70MP0006035_abnormal_mitochondrial_morpho1.14749052
71MP0000372_irregular_coat_pigmentation1.14440472
72MP0002734_abnormal_mechanical_nocicepti1.11245013
73MP0004215_abnormal_myocardial_fiber1.10102207
74MP0001986_abnormal_taste_sensitivity1.09675270
75MP0006082_CNS_inflammation1.07404721
76MP0002132_abnormal_respiratory_system1.07254196
77MP0005330_cardiomyopathy1.06335809
78MP0005165_increased_susceptibility_to1.06063516
79MP0001485_abnormal_pinna_reflex1.04878868
80MP0005084_abnormal_gallbladder_morpholo1.03875597
81MP0005386_behavior/neurological_phenoty1.02777184
82MP0004924_abnormal_behavior1.02777184
83MP0003635_abnormal_synaptic_transmissio1.02770935
84MP0005266_abnormal_metabolism1.02600736
85MP0004885_abnormal_endolymph1.01843255
86MP0003633_abnormal_nervous_system1.01396434
87MP0001666_abnormal_nutrient_absorption1.01272793
88MP0001764_abnormal_homeostasis1.01266647
89MP0005636_abnormal_mineral_homeostasis1.00428316
90MP0002736_abnormal_nociception_after0.99814726
91MP0000759_abnormal_skeletal_muscle0.99444483
92MP0000343_altered_response_to0.99123101
93MP0002735_abnormal_chemical_nociception0.98862192
94MP0006138_congestive_heart_failure0.98861996
95MP0000747_muscle_weakness0.98551713
96MP0001501_abnormal_sleep_pattern0.98232059
97MP0002090_abnormal_vision0.98216281
98MP0003631_nervous_system_phenotype0.98171903
99MP0004185_abnormal_adipocyte_glucose0.96565915
100MP0005645_abnormal_hypothalamus_physiol0.94900740
101MP0004019_abnormal_vitamin_homeostasis0.94727782
102MP0002572_abnormal_emotion/affect_behav0.94672522
103MP0005408_hypopigmentation0.94327309
104MP0002078_abnormal_glucose_homeostasis0.94210488
105MP0006276_abnormal_autonomic_nervous0.94101992
106MP0003879_abnormal_hair_cell0.92722196
107MP0002067_abnormal_sensory_capabilities0.92628437
108MP0005666_abnormal_adipose_tissue0.91844938
109MP0001970_abnormal_pain_threshold0.91776426
110MP0000013_abnormal_adipose_tissue0.91292800
111MP0000230_abnormal_systemic_arterial0.91001425
112MP0003632_abnormal_nervous_system0.90025408
113MP0003724_increased_susceptibility_to0.89610194
114MP0008872_abnormal_physiological_respon0.89111594
115MP0000750_abnormal_muscle_regeneration0.88331945
116MP0005379_endocrine/exocrine_gland_phen0.88302940
117MP0009643_abnormal_urine_homeostasis0.88141742
118MP0002332_abnormal_exercise_endurance0.86907434
119MP0002971_abnormal_brown_adipose0.86130460
120MP0001968_abnormal_touch/_nociception0.86100050
121MP0001756_abnormal_urination0.85921177
122MP0005319_abnormal_enzyme/_coenzyme0.85750035
123MP0004859_abnormal_synaptic_plasticity0.85501939
124MP0003011_delayed_dark_adaptation0.84576662
125MP0010630_abnormal_cardiac_muscle0.84154322
126MP0008995_early_reproductive_senescence0.84001621
127MP0005620_abnormal_muscle_contractility0.83771267
128MP0002063_abnormal_learning/memory/cond0.82850203
129MP0003252_abnormal_bile_duct0.81591973
130MP0005410_abnormal_fertilization0.80804509
131MP0002066_abnormal_motor_capabilities/c0.80612216
132MP0004145_abnormal_muscle_electrophysio0.80397188
133MP0005670_abnormal_white_adipose0.80317905
134MP0005551_abnormal_eye_electrophysiolog0.80023854
135MP0005253_abnormal_eye_physiology0.80003889
136MP0002972_abnormal_cardiac_muscle0.79328477
137MP0001984_abnormal_olfaction0.78318607

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.81929244
2Acute encephalopathy (HP:0006846)4.54817191
3Abnormal mitochondria in muscle tissue (HP:0008316)4.45338032
4Progressive macrocephaly (HP:0004481)4.08705284
5Mitochondrial inheritance (HP:0001427)4.05805828
6Sudden death (HP:0001699)3.97266912
7Cerebral edema (HP:0002181)3.91194996
8Muscle fiber inclusion bodies (HP:0100299)3.80930058
9Hepatocellular necrosis (HP:0001404)3.77516205
10Hepatic necrosis (HP:0002605)3.76857424
11Nemaline bodies (HP:0003798)3.67646979
12Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.62956603
13Abnormality of aromatic amino acid family metabolism (HP:0004338)3.56390466
14Increased CSF lactate (HP:0002490)3.55138816
15Bundle branch block (HP:0011710)3.54956073
16Neurofibrillary tangles (HP:0002185)3.45365593
17Leukodystrophy (HP:0002415)3.27491053
18Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.24688254
19Degeneration of the lateral corticospinal tracts (HP:0002314)3.24688254
20Exercise-induced muscle cramps (HP:0003710)3.22643029
21Pheochromocytoma (HP:0002666)3.15935614
22Parakeratosis (HP:0001036)3.15128893
23Rhabdomyolysis (HP:0003201)3.06936630
24Renal Fanconi syndrome (HP:0001994)3.04683382
25Neuroendocrine neoplasm (HP:0100634)3.01279581
26Cerebral hemorrhage (HP:0001342)2.93652329
27Abnormality of fatty-acid metabolism (HP:0004359)2.93469291
28Abnormality of the calf musculature (HP:0001430)2.91177784
29Abnormality of glycine metabolism (HP:0010895)2.90983683
30Abnormality of serine family amino acid metabolism (HP:0010894)2.90983683
31EMG: myopathic abnormalities (HP:0003458)2.86546443
32Respiratory failure (HP:0002878)2.85521733
33Lipid accumulation in hepatocytes (HP:0006561)2.85513373
343-Methylglutaconic aciduria (HP:0003535)2.84303913
35Hyperlipoproteinemia (HP:0010980)2.83928997
36Lethargy (HP:0001254)2.80051214
37Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.76255457
38Increased hepatocellular lipid droplets (HP:0006565)2.76236093
39Complement deficiency (HP:0004431)2.74238311
40Increased muscle lipid content (HP:0009058)2.73904775
41Dicarboxylic aciduria (HP:0003215)2.73364026
42Abnormality of dicarboxylic acid metabolism (HP:0010995)2.73364026
43* Lactic acidosis (HP:0003128)2.73084239
44Intrahepatic cholestasis (HP:0001406)2.72712414
45Increased intramyocellular lipid droplets (HP:0012240)2.70835264
46Methylmalonic acidemia (HP:0002912)2.69912685
47Sensory axonal neuropathy (HP:0003390)2.67616075
48Hyporeflexia of lower limbs (HP:0002600)2.65014641
49Xanthomatosis (HP:0000991)2.60763612
50Hyperglycinuria (HP:0003108)2.60198823
51Nausea (HP:0002018)2.60111650
52Asymmetric septal hypertrophy (HP:0001670)2.57096431
53* Abnormality of glycolysis (HP:0004366)2.55771563
54* Increased serum pyruvate (HP:0003542)2.55771563
55Ketosis (HP:0001946)2.53333812
56Palpitations (HP:0001962)2.52995164
57Optic disc pallor (HP:0000543)2.52626045
58Ragged-red muscle fibers (HP:0003200)2.51314549
59Methylmalonic aciduria (HP:0012120)2.51221328
60Heart block (HP:0012722)2.49893306
61Hyperglycinemia (HP:0002154)2.49714123
62Syncope (HP:0001279)2.49317897
63Hyperammonemia (HP:0001987)2.48193798
64Axonal loss (HP:0003447)2.44549015
65Prolonged partial thromboplastin time (HP:0003645)2.42876995
66Abnormality of the left ventricular outflow tract (HP:0011103)2.41713445
67Subaortic stenosis (HP:0001682)2.41713445
68Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.41530993
69Cerebral inclusion bodies (HP:0100314)2.40687305
70Spastic paraparesis (HP:0002313)2.38647708
71Abnormality of the corticospinal tract (HP:0002492)2.37383776
72Dilated cardiomyopathy (HP:0001644)2.34317118
73Muscle fiber splitting (HP:0003555)2.34120494
74Joint hemorrhage (HP:0005261)2.33927240
75Abnormality of urine glucose concentration (HP:0011016)2.32054985
76Glycosuria (HP:0003076)2.32054985
77Type 1 muscle fiber predominance (HP:0003803)2.31159855
78Ventricular tachycardia (HP:0004756)2.31057798
79CNS demyelination (HP:0007305)2.30980565
80Atrial fibrillation (HP:0005110)2.30467906
81Myokymia (HP:0002411)2.29008321
82Ketoacidosis (HP:0001993)2.26310989
83Vomiting (HP:0002013)2.24508045
84Ventricular arrhythmia (HP:0004308)2.24143419
85Exercise intolerance (HP:0003546)2.23402353
86Renal cortical cysts (HP:0000803)2.21244598
87Spontaneous abortion (HP:0005268)2.21229075
88Abnormality of aspartate family amino acid metabolism (HP:0010899)2.19609770
89Primary atrial arrhythmia (HP:0001692)2.18444243
90Hyperventilation (HP:0002883)2.18227696
91Metabolic acidosis (HP:0001942)2.16834347
92Supraventricular tachycardia (HP:0004755)2.16725332
93Ventricular fibrillation (HP:0001663)2.15604490
94Abnormal atrioventricular conduction (HP:0005150)2.15213530
95Lipoatrophy (HP:0100578)2.14523440
96Rimmed vacuoles (HP:0003805)2.14167501
97Abnormality of renal resorption (HP:0011038)2.13719386
98Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.12328854
99Deep venous thrombosis (HP:0002625)2.11465311
100Congenital ichthyosiform erythroderma (HP:0007431)2.09717423
101Neck muscle weakness (HP:0000467)2.09463673
102Muscle hypertrophy of the lower extremities (HP:0008968)2.08654762
103Supraventricular arrhythmia (HP:0005115)2.08037863
104Abnormality of methionine metabolism (HP:0010901)2.07109464
105Abnormality of serum amino acid levels (HP:0003112)2.06015342
106Focal motor seizures (HP:0011153)2.05871718
107Exercise-induced myalgia (HP:0003738)2.04642467
108Hypobetalipoproteinemia (HP:0003563)2.03486336
109Hypolipoproteinemia (HP:0010981)2.02292653
110X-linked dominant inheritance (HP:0001423)2.00694643
111* Increased serum lactate (HP:0002151)2.00498859
112Left ventricular hypertrophy (HP:0001712)1.99905204
113Generalized aminoaciduria (HP:0002909)1.99354516
114Systemic lupus erythematosus (HP:0002725)1.99325398
115Hypokalemic alkalosis (HP:0001949)1.96756465
116Hypoglycemic coma (HP:0001325)1.96264479
117Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.95565159
118Abnormal gallbladder morphology (HP:0012437)1.93417512
119Proximal tubulopathy (HP:0000114)1.92074255
120Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.91680763
121Decreased activity of mitochondrial respiratory chain (HP:0008972)1.91680763
122Gout (HP:0001997)1.90203470
123Abnormality of monocarboxylic acid metabolism (HP:0010996)1.88399078
124Hepatosplenomegaly (HP:0001433)1.87722076
125Abnormal gallbladder physiology (HP:0012438)1.83431383
126Cholecystitis (HP:0001082)1.83431383
127Myoglobinuria (HP:0002913)1.82559559
128Paraparesis (HP:0002385)1.80893237
129Cerebral hypomyelination (HP:0006808)1.80453617
130Calf muscle hypertrophy (HP:0008981)1.79616544
131Steatorrhea (HP:0002570)1.79582498
132Fat malabsorption (HP:0002630)1.78922794
133Metabolic alkalosis (HP:0200114)1.78856861
134Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.78394257
135Prolonged neonatal jaundice (HP:0006579)1.77241863
136Onion bulb formation (HP:0003383)1.76430526
137Cholelithiasis (HP:0001081)1.75458919
138Abnormality of alanine metabolism (HP:0010916)1.73711741
139Hyperalaninemia (HP:0003348)1.73711741
140Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.73711741

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.00348574
2OXSR14.15433188
3PBK2.95692716
4TAOK32.72384170
5WNK42.70850242
6MAP4K22.50755342
7BCKDK2.48471273
8CASK2.40259215
9BCR2.28832013
10EPHB12.11289254
11ARAF2.08614897
12MST41.96575378
13PKN11.95275999
14TTN1.83049255
15PDK21.68403943
16PDK41.64892475
17PDK31.64892475
18CDK191.64276274
19MUSK1.63948966
20OBSCN1.62270817
21CCNB11.60571406
22LIMK11.60396208
23PINK11.57827298
24GRK71.57782636
25PHKG21.56215974
26PHKG11.56215974
27MAPKAPK51.49083511
28CSNK1G31.46666261
29NEK11.45414871
30MYLK1.41486869
31MAPKAPK31.39145022
32NME11.38638738
33MET1.37808226
34CAMK2B1.33396238
35FRK1.32574622
36EPHA41.30054018
37CAMK2D1.27189240
38EIF2AK11.25961686
39TNIK1.25023466
40SGK4941.24894135
41SGK2231.24894135
42CAMK2G1.23643199
43WNK11.17229332
44FGFR21.15918307
45DMPK1.15441349
46MAP3K121.15377767
47CSNK1A1L1.13012706
48CSNK1G21.09916727
49CSNK1G11.09434046
50STK161.07796133
51GRK51.06817174
52ABL21.06228872
53ERBB41.05144247
54FGR1.01109001
55CAMK2A1.00803530
56MAP3K50.97067442
57ERBB30.95662200
58NEK60.92970233
59PRKCE0.91724051
60BMPR20.90879913
61PRPF4B0.90233353
62MAPK130.89224920
63BMPR1B0.88915794
64PDPK10.87642308
65PRKAA20.86840273
66ROCK20.86797647
67NTRK10.85502164
68DYRK20.82665842
69MAP2K70.81345610
70CAMKK20.79926957
71PRKAA10.79882465
72PRKCQ0.79563323
73INSRR0.79147566
74RIPK40.78994519
75AKT20.78962972
76TESK10.78655261
77GRK10.77107727
78TXK0.76817555
79TESK20.74765682
80WNK30.73919791
81ADRBK20.73158915
82PIK3CA0.71285556
83MAP2K40.69952952
84MAPK120.68642843
85MST1R0.66290857
86PIM20.66227047
87TSSK60.63594836
88PNCK0.63251080
89CAMK10.62601392
90UHMK10.61265665
91CDK50.60161516
92PLK20.58603387
93DAPK20.57819701
94PAK60.57521047
95PRKACA0.57315655
96PAK30.56305710
97MINK10.56294713
98LMTK20.54267897
99MAP3K130.54065382
100MARK10.52222793
101IRAK20.51989539
102BRAF0.51854511
103KSR20.50424749
104MAP3K40.48865351
105MAP3K140.48859486
106PDK10.47696302
107ROCK10.47478938
108PRKCG0.47259419
109SGK10.47223350
110CDK140.45495083
111NTRK20.45490132
112PRKCA0.45479772
113PRKD10.44938347
114MAP2K60.43996234
115NME20.43601021
116PRKG10.42910171
117EIF2AK30.42508511
118EPHA30.42363408
119DAPK30.40101118
120PIK3CG0.39831392
121PRKACG0.39309991
122PRKACB0.38858070
123IRAK10.38772039
124DYRK1B0.38137666
125CSNK1A10.37712669
126NTRK30.37491599
127VRK10.37038939
128SGK20.36794506
129TIE10.36737361
130STK240.36133887
131ILK0.35445327
132STK40.35118007
133DAPK10.34394013
134CDK150.34156406
135CDK180.33955360
136CSNK2A10.33345576
137PTK2B0.33324825
138ACVR1B0.33217840
139RPS6KA30.32396991

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.59418823
2Fatty acid elongation_Homo sapiens_hsa000623.39998324
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.20910173
4Parkinsons disease_Homo sapiens_hsa050122.77661381
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.75767634
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.68974583
7Propanoate metabolism_Homo sapiens_hsa006402.66994868
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.47567119
9Steroid biosynthesis_Homo sapiens_hsa001002.47242148
10Butanoate metabolism_Homo sapiens_hsa006502.42444642
11Alzheimers disease_Homo sapiens_hsa050102.21007824
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.10570642
13Fatty acid metabolism_Homo sapiens_hsa012122.03604728
14Sulfur metabolism_Homo sapiens_hsa009201.98646233
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.96545816
16Fatty acid degradation_Homo sapiens_hsa000711.92275276
17Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.92003672
18Primary bile acid biosynthesis_Homo sapiens_hsa001201.91466229
19Pyruvate metabolism_Homo sapiens_hsa006201.84857048
20Vitamin B6 metabolism_Homo sapiens_hsa007501.82761506
21Peroxisome_Homo sapiens_hsa041461.80566333
22Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.80010137
23Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.79849801
24Huntingtons disease_Homo sapiens_hsa050161.68854015
25Collecting duct acid secretion_Homo sapiens_hsa049661.67309483
26Histidine metabolism_Homo sapiens_hsa003401.66589622
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.59874399
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.52859550
29Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.51210730
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.39787893
31Tryptophan metabolism_Homo sapiens_hsa003801.36557393
32beta-Alanine metabolism_Homo sapiens_hsa004101.35248126
33PPAR signaling pathway_Homo sapiens_hsa033201.34113701
34Nitrogen metabolism_Homo sapiens_hsa009101.33105273
35Maturity onset diabetes of the young_Homo sapiens_hsa049501.29882259
36Cardiac muscle contraction_Homo sapiens_hsa042601.28766761
37Carbon metabolism_Homo sapiens_hsa012001.20823702
38Arginine biosynthesis_Homo sapiens_hsa002201.20196269
39Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.19740373
40Protein export_Homo sapiens_hsa030601.17466143
41Ether lipid metabolism_Homo sapiens_hsa005651.17007886
42Chemical carcinogenesis_Homo sapiens_hsa052041.12732503
43Arginine and proline metabolism_Homo sapiens_hsa003301.11733325
44Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.09397215
45Phenylalanine metabolism_Homo sapiens_hsa003601.07444743
46Tyrosine metabolism_Homo sapiens_hsa003501.06350994
47Steroid hormone biosynthesis_Homo sapiens_hsa001401.05017865
48Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.98152352
49Pentose and glucuronate interconversions_Homo sapiens_hsa000400.94881595
50Fatty acid biosynthesis_Homo sapiens_hsa000610.93692717
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.91939198
52Folate biosynthesis_Homo sapiens_hsa007900.86566069
53Glutathione metabolism_Homo sapiens_hsa004800.86141571
54Complement and coagulation cascades_Homo sapiens_hsa046100.85666381
55Proteasome_Homo sapiens_hsa030500.85330039
56Rheumatoid arthritis_Homo sapiens_hsa053230.84107726
57Retinol metabolism_Homo sapiens_hsa008300.83976780
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.83280927
59Metabolic pathways_Homo sapiens_hsa011000.81167950
60Cysteine and methionine metabolism_Homo sapiens_hsa002700.78542101
61Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.76972630
62Vibrio cholerae infection_Homo sapiens_hsa051100.75330248
63Linoleic acid metabolism_Homo sapiens_hsa005910.74782266
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.74518605
65Circadian rhythm_Homo sapiens_hsa047100.73248658
66alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.71461282
67Vitamin digestion and absorption_Homo sapiens_hsa049770.69172694
68Glycerolipid metabolism_Homo sapiens_hsa005610.66679838
69Dilated cardiomyopathy_Homo sapiens_hsa054140.66521842
70Regulation of autophagy_Homo sapiens_hsa041400.65995916
71One carbon pool by folate_Homo sapiens_hsa006700.63629080
72Synaptic vesicle cycle_Homo sapiens_hsa047210.58432986
73Staphylococcus aureus infection_Homo sapiens_hsa051500.57837808
74Biosynthesis of amino acids_Homo sapiens_hsa012300.57822893
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56402734
76Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.52830212
77Caffeine metabolism_Homo sapiens_hsa002320.52010937
78Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51674366
79Bile secretion_Homo sapiens_hsa049760.51486838
80GABAergic synapse_Homo sapiens_hsa047270.50599877
81Fat digestion and absorption_Homo sapiens_hsa049750.50106270
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.49423937
83Phagosome_Homo sapiens_hsa041450.48391734
84Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.46000303
85Starch and sucrose metabolism_Homo sapiens_hsa005000.45857097
86Sphingolipid metabolism_Homo sapiens_hsa006000.45515111
87Insulin secretion_Homo sapiens_hsa049110.43394459
88Circadian entrainment_Homo sapiens_hsa047130.40725905
89Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.40029403
90Arachidonic acid metabolism_Homo sapiens_hsa005900.39609594
91Pentose phosphate pathway_Homo sapiens_hsa000300.39434756
92Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.38378954
93Fructose and mannose metabolism_Homo sapiens_hsa000510.36982385
94Lysosome_Homo sapiens_hsa041420.36686369
95Renin secretion_Homo sapiens_hsa049240.35985232
96Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34538031
97Drug metabolism - other enzymes_Homo sapiens_hsa009830.34179057
98ABC transporters_Homo sapiens_hsa020100.33648596
99Glucagon signaling pathway_Homo sapiens_hsa049220.31578106
100Calcium signaling pathway_Homo sapiens_hsa040200.30251637
101Serotonergic synapse_Homo sapiens_hsa047260.29782883
102Nicotine addiction_Homo sapiens_hsa050330.26235239
103Sulfur relay system_Homo sapiens_hsa041220.25932376
104Amphetamine addiction_Homo sapiens_hsa050310.25351956
105Galactose metabolism_Homo sapiens_hsa000520.24932229
106Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.24077631
107Morphine addiction_Homo sapiens_hsa050320.22367886
108Mineral absorption_Homo sapiens_hsa049780.21838884
109Glutamatergic synapse_Homo sapiens_hsa047240.20926186
110Autoimmune thyroid disease_Homo sapiens_hsa053200.16488735
111Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.13649593
112Adipocytokine signaling pathway_Homo sapiens_hsa049200.11628740
113Ovarian steroidogenesis_Homo sapiens_hsa049130.11138356
114Graft-versus-host disease_Homo sapiens_hsa053320.10712379

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