MORF4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.71943832
2cytidine metabolic process (GO:0046087)5.11870243
3cytidine catabolic process (GO:0006216)5.11870243
4cytidine deamination (GO:0009972)5.11870243
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.92214167
6establishment of protein localization to mitochondrial membrane (GO:0090151)4.90530253
7platelet dense granule organization (GO:0060155)4.69635992
8pyrimidine ribonucleoside catabolic process (GO:0046133)4.56826983
9adaptation of signaling pathway (GO:0023058)4.37963786
10water-soluble vitamin biosynthetic process (GO:0042364)4.32194495
11nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)4.23459708
12exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 4.18564076
13mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.07218307
14response to pheromone (GO:0019236)4.02133558
15protein-cofactor linkage (GO:0018065)3.91266706
16protein polyglutamylation (GO:0018095)3.87289706
17energy coupled proton transport, down electrochemical gradient (GO:0015985)3.84296386
18ATP synthesis coupled proton transport (GO:0015986)3.84296386
19attachment of spindle microtubules to kinetochore (GO:0008608)3.68327577
20inner mitochondrial membrane organization (GO:0007007)3.66390079
21regulation of feeding behavior (GO:0060259)3.63491550
22mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.55140810
23behavioral response to nicotine (GO:0035095)3.51299239
24cullin deneddylation (GO:0010388)3.47458210
25histone H2A acetylation (GO:0043968)3.35890959
26proteasome assembly (GO:0043248)3.35738127
27intraciliary transport (GO:0042073)3.34002142
28peptidyl-histidine modification (GO:0018202)3.29834100
29sequestering of actin monomers (GO:0042989)3.19420877
30mannosylation (GO:0097502)3.16885254
31protein neddylation (GO:0045116)3.13460882
32protein deneddylation (GO:0000338)3.11376438
33chaperone-mediated protein transport (GO:0072321)3.10344101
34negative regulation of membrane potential (GO:0045837)3.10012880
35RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.08846481
36tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.08846481
37protein complex biogenesis (GO:0070271)3.01835379
38mitochondrial DNA replication (GO:0006264)3.00194899
39RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.96854353
40detection of light stimulus involved in sensory perception (GO:0050962)2.93587722
41detection of light stimulus involved in visual perception (GO:0050908)2.93587722
42protein localization to kinetochore (GO:0034501)2.92528302
43respiratory electron transport chain (GO:0022904)2.92063571
44GTP biosynthetic process (GO:0006183)2.90832973
45G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.87353884
46electron transport chain (GO:0022900)2.86987396
47negative regulation of telomere maintenance (GO:0032205)2.82465911
48DNA double-strand break processing (GO:0000729)2.81417162
49mitochondrial respiratory chain complex assembly (GO:0033108)2.78641224
50anterograde synaptic vesicle transport (GO:0048490)2.77323101
51regulation of hexokinase activity (GO:1903299)2.76131545
52regulation of glucokinase activity (GO:0033131)2.76131545
53fucosylation (GO:0036065)2.71818628
54termination of RNA polymerase III transcription (GO:0006386)2.70541928
55transcription elongation from RNA polymerase III promoter (GO:0006385)2.70541928
56intracellular protein transmembrane import (GO:0044743)2.69262398
57tachykinin receptor signaling pathway (GO:0007217)2.66697749
58retinal cone cell development (GO:0046549)2.66605379
59synaptic transmission, cholinergic (GO:0007271)2.63850990
60L-fucose catabolic process (GO:0042355)2.61130050
61fucose catabolic process (GO:0019317)2.61130050
62L-fucose metabolic process (GO:0042354)2.61130050
63indolalkylamine metabolic process (GO:0006586)2.60891016
647-methylguanosine mRNA capping (GO:0006370)2.60168976
65dopamine transport (GO:0015872)2.58835715
66protein peptidyl-prolyl isomerization (GO:0000413)2.56817804
67mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.55796845
68mitochondrial respiratory chain complex I assembly (GO:0032981)2.55796845
69NADH dehydrogenase complex assembly (GO:0010257)2.55796845
70negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.55257016
71RNA capping (GO:0036260)2.54054008
727-methylguanosine RNA capping (GO:0009452)2.54054008
73DNA demethylation (GO:0080111)2.53086988
74ketone body metabolic process (GO:1902224)2.51570551
75regulation of catecholamine metabolic process (GO:0042069)2.50527416
76regulation of dopamine metabolic process (GO:0042053)2.50527416
77fucose metabolic process (GO:0006004)2.50307505
78signal peptide processing (GO:0006465)2.50169750
79C4-dicarboxylate transport (GO:0015740)2.49646475
80anterograde axon cargo transport (GO:0008089)2.48474142
81regulation of cilium movement (GO:0003352)2.48321933
82pyrimidine ribonucleoside metabolic process (GO:0046131)2.44264511
83ribonucleoprotein complex disassembly (GO:0032988)2.43214278
84regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.40932535
85maturation of 5.8S rRNA (GO:0000460)2.40669057
86DNA strand renaturation (GO:0000733)2.40626887
87regulation of nuclear cell cycle DNA replication (GO:0033262)2.40341500
88DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.39510270
89detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.37349424
90positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.36638585
91cellular ketone body metabolic process (GO:0046950)2.36370818
92tryptophan metabolic process (GO:0006568)2.36084747
93nucleoside diphosphate phosphorylation (GO:0006165)2.35712737
94somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.35575510
95somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.35575510
96isotype switching (GO:0045190)2.35575510
97chromatin remodeling at centromere (GO:0031055)2.35129540
98recombinational repair (GO:0000725)2.34612474
99positive regulation of protein homodimerization activity (GO:0090073)2.32988283
100signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.31250757

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.27114118
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.44698215
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.38678979
4ZNF274_21170338_ChIP-Seq_K562_Hela2.85477469
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.82594410
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.80799978
7VDR_22108803_ChIP-Seq_LS180_Human2.59995058
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.50020442
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.41268740
10ELK1_19687146_ChIP-ChIP_HELA_Human2.41264327
11EWS_26573619_Chip-Seq_HEK293_Human2.36278146
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.31139417
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.28366896
14IGF1R_20145208_ChIP-Seq_DFB_Human2.20472632
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.20450503
16TAF15_26573619_Chip-Seq_HEK293_Human2.15755676
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.10424884
18POU3F2_20337985_ChIP-ChIP_501MEL_Human2.06556680
19FUS_26573619_Chip-Seq_HEK293_Human2.05581856
20GBX2_23144817_ChIP-Seq_PC3_Human1.99997772
21ETS1_20019798_ChIP-Seq_JURKAT_Human1.97805923
22PCGF2_27294783_Chip-Seq_ESCs_Mouse1.93420537
23VDR_23849224_ChIP-Seq_CD4+_Human1.88127889
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.85594816
25* P300_19829295_ChIP-Seq_ESCs_Human1.84569442
26PCGF2_27294783_Chip-Seq_NPCs_Mouse1.80813496
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.72588147
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.71947451
29TP53_22573176_ChIP-Seq_HFKS_Human1.71296206
30ELF1_17652178_ChIP-ChIP_JURKAT_Human1.70716874
31SALL1_21062744_ChIP-ChIP_HESCs_Human1.67700076
32PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63188605
33E2F4_17652178_ChIP-ChIP_JURKAT_Human1.62566782
34SRF_21415370_ChIP-Seq_HL-1_Mouse1.61184843
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.61166764
36FOXP3_21729870_ChIP-Seq_TREG_Human1.57581708
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.56231498
38GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.55302027
39POU5F1_16153702_ChIP-ChIP_HESCs_Human1.55028681
40SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.53034705
41PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.51072377
42MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.50724228
43BMI1_23680149_ChIP-Seq_NPCS_Mouse1.46832077
44EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.42620175
45SUZ12_27294783_Chip-Seq_NPCs_Mouse1.42395299
46CTBP2_25329375_ChIP-Seq_LNCAP_Human1.38481659
47NFE2_27457419_Chip-Seq_LIVER_Mouse1.37449658
48SOX2_16153702_ChIP-ChIP_HESCs_Human1.34680023
49SOX2_19829295_ChIP-Seq_ESCs_Human1.31347147
50NANOG_19829295_ChIP-Seq_ESCs_Human1.31347147
51NOTCH1_21737748_ChIP-Seq_TLL_Human1.31002114
52EZH2_22144423_ChIP-Seq_EOC_Human1.30820195
53MYC_18940864_ChIP-ChIP_HL60_Human1.30587208
54CREB1_15753290_ChIP-ChIP_HEK293T_Human1.25033895
55NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.23981208
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23434653
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.23044587
58SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22485547
59CBP_20019798_ChIP-Seq_JUKART_Human1.21461803
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.21461803
61BCAT_22108803_ChIP-Seq_LS180_Human1.20939836
62KLF5_20875108_ChIP-Seq_MESCs_Mouse1.20650387
63EZH2_27294783_Chip-Seq_NPCs_Mouse1.19192718
64FOXA1_25329375_ChIP-Seq_VCAP_Human1.17306483
65FOXA1_27270436_Chip-Seq_PROSTATE_Human1.17306483
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16219503
67PADI4_21655091_ChIP-ChIP_MCF-7_Human1.13728485
68MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13718964
69FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.13392799
70NANOG_16153702_ChIP-ChIP_HESCs_Human1.11502553
71EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10405324
72UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09585126
73PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.09144589
74P53_22387025_ChIP-Seq_ESCs_Mouse1.08431278
75TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08273170
76YY1_21170310_ChIP-Seq_MESCs_Mouse1.08180553
77THAP11_20581084_ChIP-Seq_MESCs_Mouse1.08099293
78NCOR_22424771_ChIP-Seq_293T_Human1.06707348
79CBX2_27304074_Chip-Seq_ESCs_Mouse1.05683260
80NANOG_18555785_Chip-Seq_ESCs_Mouse1.05680099
81AUTS2_25519132_ChIP-Seq_293T-REX_Human1.05199323
82TCF4_22108803_ChIP-Seq_LS180_Human1.05167345
83FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.04670857
84KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.04497772
85ETV2_25802403_ChIP-Seq_MESCs_Mouse1.03578042
86AR_25329375_ChIP-Seq_VCAP_Human1.03524172
87AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03523834
88POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01634701
89TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01634701
90* RUNX2_22187159_ChIP-Seq_PCA_Human1.00801134
91BP1_19119308_ChIP-ChIP_Hs578T_Human0.99910778
92DCP1A_22483619_ChIP-Seq_HELA_Human0.98428639
93RNF2_27304074_Chip-Seq_NSC_Mouse0.98299871
94ER_23166858_ChIP-Seq_MCF-7_Human0.97664042
95STAT3_18555785_Chip-Seq_ESCs_Mouse0.97528622
96CRX_20693478_ChIP-Seq_RETINA_Mouse0.97349188
97STAT3_23295773_ChIP-Seq_U87_Human0.97247243
98HTT_18923047_ChIP-ChIP_STHdh_Human0.96846847
99TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95612998
100SMAD4_21799915_ChIP-Seq_A2780_Human0.95332576

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology3.21403428
2MP0008877_abnormal_DNA_methylation3.09811706
3MP0006292_abnormal_olfactory_placode2.92106989
4MP0000372_irregular_coat_pigmentation2.76463504
5MP0001188_hyperpigmentation2.57498628
6MP0003011_delayed_dark_adaptation2.56849316
7MP0004142_abnormal_muscle_tone2.28630557
8MP0001968_abnormal_touch/_nociception2.25821210
9MP0001905_abnormal_dopamine_level2.16660714
10MP0002736_abnormal_nociception_after2.15826584
11MP0003787_abnormal_imprinting2.07948368
12MP0005084_abnormal_gallbladder_morpholo2.04133286
13MP0005645_abnormal_hypothalamus_physiol2.02497200
14MP0006072_abnormal_retinal_apoptosis2.01630634
15MP0005551_abnormal_eye_electrophysiolog2.01207691
16MP0002837_dystrophic_cardiac_calcinosis1.99332960
17MP0005360_urolithiasis1.99315623
18MP0004147_increased_porphyrin_level1.91972578
19MP0009046_muscle_twitch1.89059278
20MP0003122_maternal_imprinting1.88462772
21MP0001529_abnormal_vocalization1.88366099
22MP0003186_abnormal_redox_activity1.85891552
23MP0008875_abnormal_xenobiotic_pharmacok1.85663488
24MP0002234_abnormal_pharynx_morphology1.85468827
25MP0009745_abnormal_behavioral_response1.83982631
26MP0002909_abnormal_adrenal_gland1.79762580
27MP0003786_premature_aging1.69518301
28MP0005253_abnormal_eye_physiology1.68932198
29MP0006276_abnormal_autonomic_nervous1.65801978
30MP0002638_abnormal_pupillary_reflex1.61633931
31MP0001486_abnormal_startle_reflex1.58474626
32MP0003121_genomic_imprinting1.57127716
33MP0003718_maternal_effect1.54840569
34MP0002938_white_spotting1.54059634
35MP0001293_anophthalmia1.53826577
36MP0002272_abnormal_nervous_system1.50497690
37MP0009697_abnormal_copulation1.49010254
38MP0002822_catalepsy1.47620637
39MP0000013_abnormal_adipose_tissue1.46907923
40MP0003937_abnormal_limbs/digits/tail_de1.46513309
41MP0002653_abnormal_ependyma_morphology1.45418294
42MP0003283_abnormal_digestive_organ1.39110981
43MP0000049_abnormal_middle_ear1.36860484
44MP0004885_abnormal_endolymph1.36620167
45MP0008872_abnormal_physiological_respon1.31299268
46MP0005167_abnormal_blood-brain_barrier1.29631819
47MP0002572_abnormal_emotion/affect_behav1.28610105
48MP0001440_abnormal_grooming_behavior1.26688293
49MP0002876_abnormal_thyroid_physiology1.24608508
50MP0003567_abnormal_fetal_cardiomyocyte1.23128095
51MP0000639_abnormal_adrenal_gland1.22133167
52MP0003880_abnormal_central_pattern1.20616013
53MP0002733_abnormal_thermal_nociception1.20077541
54MP0001485_abnormal_pinna_reflex1.18084816
55MP0004133_heterotaxia1.15973205
56MP0003693_abnormal_embryo_hatching1.15614887
57MP0000778_abnormal_nervous_system1.15413023
58MP0002751_abnormal_autonomic_nervous1.14825612
59MP0002064_seizures1.11606666
60MP0000631_abnormal_neuroendocrine_gland1.11595727
61MP0001984_abnormal_olfaction1.09348080
62MP0002557_abnormal_social/conspecific_i1.08908465
63MP0004215_abnormal_myocardial_fiber1.01444480
64MP0006054_spinal_hemorrhage0.97359403
65MP0004145_abnormal_muscle_electrophysio0.96773416
66MP0003195_calcinosis0.96212047
67MP0006035_abnormal_mitochondrial_morpho0.95410383
68MP0005195_abnormal_posterior_eye0.95354145
69MP0003137_abnormal_impulse_conducting0.93657973
70MP0006036_abnormal_mitochondrial_physio0.91210326
71MP0002138_abnormal_hepatobiliary_system0.88902257
72MP0005171_absent_coat_pigmentation0.88429350
73MP0005075_abnormal_melanosome_morpholog0.88337337
74MP0005391_vision/eye_phenotype0.88145441
75MP0008058_abnormal_DNA_repair0.87785666
76MP0000427_abnormal_hair_cycle0.87601011
77MP0002067_abnormal_sensory_capabilities0.85905029
78MP0003635_abnormal_synaptic_transmissio0.85728185
79MP0005386_behavior/neurological_phenoty0.84771094
80MP0004924_abnormal_behavior0.84771094
81MP0001970_abnormal_pain_threshold0.82806213
82MP0002069_abnormal_eating/drinking_beha0.82091090
83MP0003119_abnormal_digestive_system0.81232406
84MP0008789_abnormal_olfactory_epithelium0.80706691
85MP0002752_abnormal_somatic_nervous0.80097969
86MP0002210_abnormal_sex_determination0.79827650
87MP0002282_abnormal_trachea_morphology0.79757535
88MP0002063_abnormal_learning/memory/cond0.78553657
89MP0009379_abnormal_foot_pigmentation0.78487676
90MP0002090_abnormal_vision0.75908463
91MP0003638_abnormal_response/metabolism_0.75642087
92MP0002229_neurodegeneration0.75112489
93MP0008995_early_reproductive_senescence0.75052926
94MP0002095_abnormal_skin_pigmentation0.72528024
95MP0001929_abnormal_gametogenesis0.69953450
96MP0002184_abnormal_innervation0.69363026
97MP0000516_abnormal_urinary_system0.68654109
98MP0005367_renal/urinary_system_phenotyp0.68654109
99MP0004883_abnormal_blood_vessel0.68651583
100MP0000538_abnormal_urinary_bladder0.68575533

Predicted human phenotypes

RankGene SetZ-score
1Type II lissencephaly (HP:0007260)4.34384386
2Retinal dysplasia (HP:0007973)4.22928480
3Molar tooth sign on MRI (HP:0002419)3.62219364
4Abnormality of midbrain morphology (HP:0002418)3.62219364
5Pancreatic cysts (HP:0001737)3.60946328
6Abolished electroretinogram (ERG) (HP:0000550)3.46784384
7Pancreatic fibrosis (HP:0100732)3.37273578
8True hermaphroditism (HP:0010459)3.36032341
9Acute necrotizing encephalopathy (HP:0006965)3.34985265
10Lissencephaly (HP:0001339)3.29073730
11Nephronophthisis (HP:0000090)3.13428590
12Congenital stationary night blindness (HP:0007642)3.01517094
13Abnormal mitochondria in muscle tissue (HP:0008316)2.88085668
14Acute encephalopathy (HP:0006846)2.85664642
15Poor suck (HP:0002033)2.81971306
16Hypothermia (HP:0002045)2.80290915
17Neoplasm of the adrenal gland (HP:0100631)2.77857172
18Abnormality of the labia minora (HP:0012880)2.70306321
19Progressive macrocephaly (HP:0004481)2.67709621
20Decreased electroretinogram (ERG) amplitude (HP:0000654)2.67030366
21Limb dystonia (HP:0002451)2.62361560
22Generalized aminoaciduria (HP:0002909)2.53465954
23Colon cancer (HP:0003003)2.52236246
24Increased CSF lactate (HP:0002490)2.50603420
25Mitochondrial inheritance (HP:0001427)2.47827582
26Type I transferrin isoform profile (HP:0003642)2.47715177
27Medial flaring of the eyebrow (HP:0010747)2.47125534
28Bifid tongue (HP:0010297)2.39272931
29Sclerocornea (HP:0000647)2.36682794
30Aplasia/hypoplasia of the uterus (HP:0008684)2.34669073
31Neuroendocrine neoplasm (HP:0100634)2.33023905
32Abnormality of the renal medulla (HP:0100957)2.32224713
333-Methylglutaconic aciduria (HP:0003535)2.31647711
34Humeroradial synostosis (HP:0003041)2.30153380
35Synostosis involving the elbow (HP:0003938)2.30153380
36Cerebral edema (HP:0002181)2.28533775
37Pachygyria (HP:0001302)2.26449216
38Hypoproteinemia (HP:0003075)2.24695777
39Polyphagia (HP:0002591)2.20682473
40Pheochromocytoma (HP:0002666)2.19959555
41Anencephaly (HP:0002323)2.19623534
42Short tibia (HP:0005736)2.19535753
43Hepatic necrosis (HP:0002605)2.19073483
44Abnormal protein glycosylation (HP:0012346)2.18852261
45Abnormal glycosylation (HP:0012345)2.18852261
46Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.18852261
47Abnormal protein N-linked glycosylation (HP:0012347)2.18852261
48Hypoplasia of the pons (HP:0012110)2.17023284
49Abnormality of the pons (HP:0007361)2.12921908
50Microretrognathia (HP:0000308)2.12478330
51Large for gestational age (HP:0001520)2.11644297
52Failure to thrive in infancy (HP:0001531)2.11152337
53Cerebellar dysplasia (HP:0007033)2.10575545
54Postaxial hand polydactyly (HP:0001162)2.09750747
55Retinal atrophy (HP:0001105)2.04719307
56Aplasia/Hypoplasia of the tibia (HP:0005772)2.03228990
57Supernumerary spleens (HP:0009799)2.00938777
58Bile duct proliferation (HP:0001408)1.98201557
59Abnormal biliary tract physiology (HP:0012439)1.98201557
60Severe muscular hypotonia (HP:0006829)1.97428924
61Proximal tubulopathy (HP:0000114)1.96489598
62Aplasia/Hypoplasia of the tongue (HP:0010295)1.95100684
63Hepatocellular necrosis (HP:0001404)1.94224368
64Neoplasm of the adrenal cortex (HP:0100641)1.93526784
65Renal cortical cysts (HP:0000803)1.92284977
66Bilateral microphthalmos (HP:0007633)1.91797920
67Preaxial hand polydactyly (HP:0001177)1.91110746
68Congenital, generalized hypertrichosis (HP:0004540)1.90663210
69Dyschromatopsia (HP:0007641)1.90402166
70Increased corneal curvature (HP:0100692)1.86706626
71Keratoconus (HP:0000563)1.86706626
72Aplastic anemia (HP:0001915)1.86674730
73Reduced antithrombin III activity (HP:0001976)1.86219963
74Disproportionate short-trunk short stature (HP:0003521)1.85709219
75Thyroiditis (HP:0100646)1.85327035
76Anterior segment dysgenesis (HP:0007700)1.84881148
77Papillary thyroid carcinoma (HP:0002895)1.83441932
78Attenuation of retinal blood vessels (HP:0007843)1.80816060
79Optic nerve hypoplasia (HP:0000609)1.79993192
80Dandy-Walker malformation (HP:0001305)1.79644134
81Agitation (HP:0000713)1.79277739
82Cystic liver disease (HP:0006706)1.79048285
83Abnormal rod and cone electroretinograms (HP:0008323)1.77973756
84Renal dysplasia (HP:0000110)1.75543841
85Constricted visual fields (HP:0001133)1.74735633
86Arthropathy (HP:0003040)1.73472424
87Inability to walk (HP:0002540)1.73244086
88Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.72911889
89Decreased activity of mitochondrial respiratory chain (HP:0008972)1.72426523
90Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.72426523
91Narrow forehead (HP:0000341)1.71491050
92Gait imbalance (HP:0002141)1.71433369
93Abnormality of the renal cortex (HP:0011035)1.70842179
94Postaxial foot polydactyly (HP:0001830)1.68818882
95Lethargy (HP:0001254)1.68490583
96Decreased muscle mass (HP:0003199)1.68417351
97Furrowed tongue (HP:0000221)1.67699264
98Abnormality of macular pigmentation (HP:0008002)1.67505337
99Tongue fasciculations (HP:0001308)1.67053864
100Focal motor seizures (HP:0011153)1.65640546

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.16958759
2TRIM283.15516877
3WNK32.77186654
4VRK22.64953868
5PNCK2.50951273
6TAF12.25982338
7BMPR1B2.25239073
8EIF2AK12.22803967
9EIF2AK32.22088793
10PINK12.01081282
11GRK12.00226713
12MST41.91345202
13NEK11.77633327
14TXK1.74082795
15ADRBK21.70938385
16NUAK11.70909671
17DYRK21.69355854
18MAP3K121.65978381
19CSNK1G31.65080270
20TAOK31.62711769
21MKNK21.59386587
22TIE11.53968512
23CSNK1G11.52178345
24VRK11.49662372
25ZAK1.46778821
26MAPK131.44044970
27PLK31.43433499
28SIK31.41724480
29WEE11.41072008
30CSNK1G21.39934970
31MAP2K71.38523017
32BCR1.36461126
33CCNB11.30830124
34PLK21.28856952
35MAP4K21.27857990
36TSSK61.27759313
37PRKCG1.25123657
38WNK41.23839769
39BCKDK1.23673873
40MAP3K41.21282369
41PIM21.20750744
42CSNK1A1L1.18747412
43FRK1.17551200
44MARK11.17399265
45MKNK11.13198369
46SRPK11.11308635
47EIF2AK21.09174465
48PRKCE1.04571219
49UHMK11.02550990
50OXSR11.01166918
51TGFBR11.01138461
52NME10.97645663
53GRK70.94309413
54ARAF0.94212468
55LIMK10.86686863
56PAK30.85722770
57GRK50.83833504
58PHKG10.83452422
59PHKG20.83452422
60PRKCI0.82019010
61CDC70.80557550
62PRKCQ0.78653324
63TLK10.74381266
64EPHB20.74197233
65STK390.68647184
66DAPK20.66416377
67INSRR0.64825138
68PLK10.64672797
69TAOK10.60636951
70ADRBK10.58781935
71RPS6KA50.58554443
72FLT30.58190448
73MINK10.55808970
74ACVR1B0.55358030
75TTK0.54979175
76DAPK30.54256712
77MAP2K60.53878491
78ATR0.52689540
79TESK10.50976735
80ERBB30.50750971
81KDR0.50687623
82DYRK1A0.47510741
83CDK80.46835009
84PTK2B0.46538536
85PRKG10.42697276
86CAMK2A0.42269378
87MAPKAPK50.40465549
88PRKACA0.38548922
89CSNK1A10.38506563
90ERBB40.38314067
91AURKB0.38247443
92PASK0.36463022
93BRSK20.35875586
94CSNK2A10.35809467
95CDK180.35054896
96CDK140.34939444
97ATM0.34831288
98CSNK1E0.31683752
99ITK0.29772634
100CDK190.29551688

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.81061221
2Oxidative phosphorylation_Homo sapiens_hsa001903.63886853
3Proteasome_Homo sapiens_hsa030503.11703440
4Parkinsons disease_Homo sapiens_hsa050123.08770332
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.52827593
6Phototransduction_Homo sapiens_hsa047442.27974587
7RNA polymerase_Homo sapiens_hsa030202.24171619
8Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.15331228
9Basal transcription factors_Homo sapiens_hsa030222.14717644
10Huntingtons disease_Homo sapiens_hsa050162.14285692
11Sulfur metabolism_Homo sapiens_hsa009202.03153411
12Fatty acid elongation_Homo sapiens_hsa000621.98847515
13Alzheimers disease_Homo sapiens_hsa050101.91357686
14Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.73867968
15RNA degradation_Homo sapiens_hsa030181.73038327
16Non-homologous end-joining_Homo sapiens_hsa034501.70628808
17Selenocompound metabolism_Homo sapiens_hsa004501.59454047
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.57007694
19Butanoate metabolism_Homo sapiens_hsa006501.56761079
20Nitrogen metabolism_Homo sapiens_hsa009101.55809921
21Propanoate metabolism_Homo sapiens_hsa006401.47307770
22Caffeine metabolism_Homo sapiens_hsa002321.42955092
23Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.41613667
24Nicotine addiction_Homo sapiens_hsa050331.41590173
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.39575011
26Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.36719385
27Collecting duct acid secretion_Homo sapiens_hsa049661.35095761
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.32280521
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.29186722
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.29132094
31Cardiac muscle contraction_Homo sapiens_hsa042601.26025372
32Homologous recombination_Homo sapiens_hsa034401.25541938
33Regulation of autophagy_Homo sapiens_hsa041401.23572400
34Linoleic acid metabolism_Homo sapiens_hsa005911.20017359
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.13011536
36Primary immunodeficiency_Homo sapiens_hsa053401.11781770
37Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.10594948
38Spliceosome_Homo sapiens_hsa030401.08645870
39Tryptophan metabolism_Homo sapiens_hsa003801.07542727
40Maturity onset diabetes of the young_Homo sapiens_hsa049501.07219291
41Pyrimidine metabolism_Homo sapiens_hsa002401.05320589
42Base excision repair_Homo sapiens_hsa034101.01214943
43Folate biosynthesis_Homo sapiens_hsa007901.01180814
44Fatty acid metabolism_Homo sapiens_hsa012121.00879564
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.99081926
46Nucleotide excision repair_Homo sapiens_hsa034200.98030336
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.97106264
48Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.95657910
49Peroxisome_Homo sapiens_hsa041460.94411964
50RNA transport_Homo sapiens_hsa030130.93066058
51Fanconi anemia pathway_Homo sapiens_hsa034600.91957687
52Ribosome_Homo sapiens_hsa030100.90724684
53Purine metabolism_Homo sapiens_hsa002300.87786285
54Pyruvate metabolism_Homo sapiens_hsa006200.85791630
55Cysteine and methionine metabolism_Homo sapiens_hsa002700.85566429
56Mismatch repair_Homo sapiens_hsa034300.83487622
57Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.82051745
58Pentose and glucuronate interconversions_Homo sapiens_hsa000400.81146837
59Dopaminergic synapse_Homo sapiens_hsa047280.76274664
60p53 signaling pathway_Homo sapiens_hsa041150.74801198
61Intestinal immune network for IgA production_Homo sapiens_hsa046720.73823864
62Ether lipid metabolism_Homo sapiens_hsa005650.71947223
63Metabolic pathways_Homo sapiens_hsa011000.71503156
64Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.71020294
65Rheumatoid arthritis_Homo sapiens_hsa053230.70738842
66Steroid biosynthesis_Homo sapiens_hsa001000.69241100
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.67970449
68Primary bile acid biosynthesis_Homo sapiens_hsa001200.65989904
69Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.65355279
70Retinol metabolism_Homo sapiens_hsa008300.65122795
71Olfactory transduction_Homo sapiens_hsa047400.63758965
72Oocyte meiosis_Homo sapiens_hsa041140.61331869
73GABAergic synapse_Homo sapiens_hsa047270.60878781
74Synaptic vesicle cycle_Homo sapiens_hsa047210.60558493
75Hedgehog signaling pathway_Homo sapiens_hsa043400.60154726
76Serotonergic synapse_Homo sapiens_hsa047260.60078973
77Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57153706
78Glutamatergic synapse_Homo sapiens_hsa047240.56828805
79Fatty acid degradation_Homo sapiens_hsa000710.54616054
80Morphine addiction_Homo sapiens_hsa050320.54597873
81beta-Alanine metabolism_Homo sapiens_hsa004100.52362088
82Taste transduction_Homo sapiens_hsa047420.52082930
83Amphetamine addiction_Homo sapiens_hsa050310.51137470
84Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.50074441
85Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.49114029
86Type I diabetes mellitus_Homo sapiens_hsa049400.46657388
87Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.46605192
88Chemical carcinogenesis_Homo sapiens_hsa052040.46218728
89One carbon pool by folate_Homo sapiens_hsa006700.46047607
90Fat digestion and absorption_Homo sapiens_hsa049750.45736946
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45241353
92mRNA surveillance pathway_Homo sapiens_hsa030150.45063095
93Vibrio cholerae infection_Homo sapiens_hsa051100.44486535
94Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42762130
95DNA replication_Homo sapiens_hsa030300.40102538
96Circadian entrainment_Homo sapiens_hsa047130.38215750
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37982348
98Insulin secretion_Homo sapiens_hsa049110.37166387
99Antigen processing and presentation_Homo sapiens_hsa046120.33541590
100Systemic lupus erythematosus_Homo sapiens_hsa053220.30717495

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