MON2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.84152152
2axon ensheathment in central nervous system (GO:0032291)4.79520579
3central nervous system myelination (GO:0022010)4.79520579
4cellular response to ethanol (GO:0071361)4.67669057
5interkinetic nuclear migration (GO:0022027)4.57568345
6fatty acid elongation (GO:0030497)4.07111403
7monoubiquitinated protein deubiquitination (GO:0035520)4.04124561
8ensheathment of neurons (GO:0007272)3.77121514
9axon ensheathment (GO:0008366)3.77121514
10myelination (GO:0042552)3.73787463
11protein localization to endosome (GO:0036010)3.71627563
12protein K48-linked deubiquitination (GO:0071108)3.69658466
13neural tube formation (GO:0001841)3.47689305
14erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.41690305
15L-phenylalanine catabolic process (GO:0006559)3.41690305
16negative regulation of neurotransmitter secretion (GO:0046929)3.33577899
17positive regulation of developmental pigmentation (GO:0048087)3.24916207
18UDP-N-acetylglucosamine metabolic process (GO:0006047)3.24811237
19myelin maintenance (GO:0043217)3.24349226
20response to lipoprotein particle (GO:0055094)3.23693632
21histone H3-K4 trimethylation (GO:0080182)3.22711115
22nucleus localization (GO:0051647)3.21717609
23nerve growth factor signaling pathway (GO:0038180)3.12560217
24long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.08311674
25regulation of pigment cell differentiation (GO:0050932)3.07377340
26import into cell (GO:0098657)3.04667702
27histone mRNA catabolic process (GO:0071044)3.04083115
28COPII vesicle coating (GO:0048208)3.04070469
29retrograde transport, vesicle recycling within Golgi (GO:0000301)3.03373988
30early endosome to late endosome transport (GO:0045022)3.02264844
31response to methylmercury (GO:0051597)3.02042257
32regulation of establishment of cell polarity (GO:2000114)2.98738970
33fatty-acyl-CoA biosynthetic process (GO:0046949)2.97361906
34creatine metabolic process (GO:0006600)2.97222462
35alpha-linolenic acid metabolic process (GO:0036109)2.94182792
36cerebellar Purkinje cell differentiation (GO:0021702)2.93636327
37protein K63-linked deubiquitination (GO:0070536)2.93335378
38L-phenylalanine metabolic process (GO:0006558)2.85946374
39erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.85946374
40asymmetric protein localization (GO:0008105)2.85156335
41protein targeting to lysosome (GO:0006622)2.83833811
42establishment of protein localization to vacuole (GO:0072666)2.83833811
43protein targeting to vacuole (GO:0006623)2.83833811
44negative regulation of cAMP-mediated signaling (GO:0043951)2.77918372
45L-amino acid import (GO:0043092)2.76290845
46regulation of histone H3-K27 methylation (GO:0061085)2.76097534
47virion attachment to host cell (GO:0019062)2.75813207
48adhesion of symbiont to host cell (GO:0044650)2.75813207
49nuclear pore organization (GO:0006999)2.74986000
50protein K11-linked deubiquitination (GO:0035871)2.74165491
51regulation of protein polyubiquitination (GO:1902914)2.74006412
52protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.73312754
53protein localization to Golgi apparatus (GO:0034067)2.72583443
54growth hormone receptor signaling pathway (GO:0060396)2.72064152
55* Golgi to endosome transport (GO:0006895)2.71200616
56peptidyl-lysine trimethylation (GO:0018023)2.70470561
57insulin-like growth factor receptor signaling pathway (GO:0048009)2.69892314
58cytoskeletal anchoring at plasma membrane (GO:0007016)2.69342311
59phosphatidylinositol phosphorylation (GO:0046854)2.67647584
60glycerophospholipid catabolic process (GO:0046475)2.67370148
61intra-Golgi vesicle-mediated transport (GO:0006891)2.66803899
62iron ion import (GO:0097286)2.65577855
63cytoplasmic mRNA processing body assembly (GO:0033962)2.64750288
64regulation of establishment or maintenance of cell polarity (GO:0032878)2.64282866
65regulation of lipoprotein metabolic process (GO:0050746)2.63970322
66pericardium development (GO:0060039)2.61805893
67interleukin-6-mediated signaling pathway (GO:0070102)2.60794349
68amino-acid betaine transport (GO:0015838)2.60110773
69carnitine transport (GO:0015879)2.60110773
70peptidyl-tyrosine autophosphorylation (GO:0038083)2.60035415
71carnitine transmembrane transport (GO:1902603)2.59836361
72regulation of membrane lipid distribution (GO:0097035)2.59145156
73long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.56076288
74apical protein localization (GO:0045176)2.54694941
75regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.54445064
76gastrulation with mouth forming second (GO:0001702)2.54333142
77carnitine shuttle (GO:0006853)2.53888005
78nuclear pore complex assembly (GO:0051292)2.53656606
79negative regulation of neurotransmitter transport (GO:0051589)2.53312511
80very long-chain fatty acid metabolic process (GO:0000038)2.52671676
81thioester biosynthetic process (GO:0035384)2.52355774
82acyl-CoA biosynthetic process (GO:0071616)2.52355774
83genitalia morphogenesis (GO:0035112)2.51816478
84establishment of nucleus localization (GO:0040023)2.50452463
85negative regulation of complement activation (GO:0045916)2.49493458
86cholesterol biosynthetic process (GO:0006695)2.46878373
87fatty-acyl-CoA metabolic process (GO:0035337)2.46694505
88myelination in peripheral nervous system (GO:0022011)2.45980106
89peripheral nervous system axon ensheathment (GO:0032292)2.45980106
90mannose metabolic process (GO:0006013)2.44705102
91cortical actin cytoskeleton organization (GO:0030866)2.43474606
92regulation of protein glycosylation (GO:0060049)2.43440172
93platelet-derived growth factor receptor signaling pathway (GO:0048008)2.42952159
94intestinal epithelial cell development (GO:0060576)2.42189600
95dosage compensation (GO:0007549)2.41774656
96fibroblast migration (GO:0010761)2.40779615
97membrane tubulation (GO:0097320)2.40260084
98prostate gland growth (GO:0060736)2.39341119
99negative regulation of protein activation cascade (GO:2000258)2.37143940
100microtubule nucleation (GO:0007020)2.37139549
101negative regulation of cytosolic calcium ion concentration (GO:0051481)2.35867097
102embryonic retina morphogenesis in camera-type eye (GO:0060059)2.35315343
103toxin transport (GO:1901998)2.34534289
104cellular response to cholesterol (GO:0071397)2.34501353
105cellular response to growth hormone stimulus (GO:0071378)2.34253508
106long-chain fatty acid biosynthetic process (GO:0042759)2.32670411
107macroautophagy (GO:0016236)2.32263597
108histone lysine demethylation (GO:0070076)2.31673810
109fatty acid transmembrane transport (GO:1902001)2.31369979
110protein carboxylation (GO:0018214)2.31157079
111peptidyl-glutamic acid carboxylation (GO:0017187)2.31157079
112regulation of translation, ncRNA-mediated (GO:0045974)2.30131421
113negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.30131421
114negative regulation of translation, ncRNA-mediated (GO:0040033)2.30131421
115positive regulation of fatty acid beta-oxidation (GO:0032000)2.29109037
116embryonic camera-type eye morphogenesis (GO:0048596)2.28433105
117adhesion of symbiont to host (GO:0044406)2.28255465
118vesicle transport along microtubule (GO:0047496)2.25102699
119regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.24186467
120positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.23700674
121photoreceptor cell differentiation (GO:0046530)2.23119004
122eye photoreceptor cell differentiation (GO:0001754)2.23119004
123regulation of B cell receptor signaling pathway (GO:0050855)2.22996887
124mitochondrion distribution (GO:0048311)2.22881139
125definitive hemopoiesis (GO:0060216)2.21890296
126microtubule anchoring (GO:0034453)2.21620408
127plasma lipoprotein particle clearance (GO:0034381)2.21549522
128cellular response to nerve growth factor stimulus (GO:1990090)2.20341278
129response to nerve growth factor (GO:1990089)2.20341278
130regulation of cholesterol homeostasis (GO:2000188)2.19912433
131cortical cytoskeleton organization (GO:0030865)2.18800215
132Golgi organization (GO:0007030)2.18674855
133histone demethylation (GO:0016577)2.18533571
134phospholipid homeostasis (GO:0055091)2.16984655
135lipid phosphorylation (GO:0046834)2.16774587
136positive regulation of granulocyte differentiation (GO:0030854)2.16633817
137regulation of ARF GTPase activity (GO:0032312)2.15798405
138cholesterol metabolic process (GO:0008203)2.15412715
139oligodendrocyte differentiation (GO:0048709)2.13883203
140positive regulation of cardiac muscle hypertrophy (GO:0010613)2.13851541
141positive regulation of muscle hypertrophy (GO:0014742)2.13851541
142sterol biosynthetic process (GO:0016126)2.13776859
143cholesterol efflux (GO:0033344)2.13645121
144L-serine transport (GO:0015825)2.13555819
145regulation of cholesterol biosynthetic process (GO:0045540)2.12910927
146phosphatidylinositol dephosphorylation (GO:0046856)2.12872038
147peptidyl-lysine methylation (GO:0018022)2.11984401
148lipid translocation (GO:0034204)2.11837928
149phospholipid translocation (GO:0045332)2.11837928
150amyloid precursor protein metabolic process (GO:0042982)2.11109275
151regulation of ARF protein signal transduction (GO:0032012)2.11074628
152regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)2.10642133
153amino acid import (GO:0043090)2.09697709
154pore complex assembly (GO:0046931)2.09675576
155regulation of RNA export from nucleus (GO:0046831)2.09671520
156protein-lipid complex assembly (GO:0065005)2.09633078
157histone H3-K36 demethylation (GO:0070544)2.09297051
158positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.09287076
159protein targeting to Golgi (GO:0000042)2.08651095
160triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.08288314
161dendrite morphogenesis (GO:0048813)2.07449818
162cilium or flagellum-dependent cell motility (GO:0001539)2.07194434
163aromatic amino acid family catabolic process (GO:0009074)2.06655089
164phospholipid dephosphorylation (GO:0046839)2.05735962
165cellular response to sterol (GO:0036315)2.05552522
166histone H3-K9 demethylation (GO:0033169)2.03965752
167glycosylceramide metabolic process (GO:0006677)2.03507775
168apoptotic cell clearance (GO:0043277)2.03447902
169tyrosine metabolic process (GO:0006570)2.03325492
170establishment of protein localization to Golgi (GO:0072600)2.01973499
171membrane protein ectodomain proteolysis (GO:0006509)2.01558375
172regulation of membrane protein ectodomain proteolysis (GO:0051043)1.96883090
173triglyceride biosynthetic process (GO:0019432)1.96753872
174negative regulation of protein localization to cell surface (GO:2000009)1.96212862
175establishment of mitochondrion localization (GO:0051654)1.94998250
176sterol metabolic process (GO:0016125)1.94689136
177response to laminar fluid shear stress (GO:0034616)1.94233700
178intestinal cholesterol absorption (GO:0030299)1.93904616
179acetyl-CoA metabolic process (GO:0006084)1.93884597
180regulation of triglyceride catabolic process (GO:0010896)1.93317060
181bile acid biosynthetic process (GO:0006699)1.92317242
182acylglycerol biosynthetic process (GO:0046463)1.91782119
183neutral lipid biosynthetic process (GO:0046460)1.91782119
184short-chain fatty acid metabolic process (GO:0046459)1.91011096
185cysteine metabolic process (GO:0006534)1.90569556
186low-density lipoprotein particle clearance (GO:0034383)1.90341605

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SALL1_21062744_ChIP-ChIP_HESCs_Human2.90294225
2POU3F2_20337985_ChIP-ChIP_501MEL_Human2.61498395
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.51264592
4* LXR_22158963_ChIP-Seq_LIVER_Mouse2.25158396
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.08773210
6RXR_22158963_ChIP-Seq_LIVER_Mouse2.05440395
7CDX2_19796622_ChIP-Seq_MESCs_Mouse1.83940446
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.82757875
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.82317404
10SMAD4_21799915_ChIP-Seq_A2780_Human1.81910861
11* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.79213214
12GATA1_22025678_ChIP-Seq_K562_Human1.78481477
13TAF15_26573619_Chip-Seq_HEK293_Human1.78466274
14VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.77536296
15IGF1R_20145208_ChIP-Seq_DFB_Human1.74657323
16ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.70241041
17TRIM28_21343339_ChIP-Seq_HEK293_Human1.68962608
18GBX2_23144817_ChIP-Seq_PC3_Human1.67667938
19ESR2_21235772_ChIP-Seq_MCF-7_Human1.66803893
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.66525604
21FOXA2_19822575_ChIP-Seq_HepG2_Human1.65905920
22* ER_23166858_ChIP-Seq_MCF-7_Human1.64747239
23* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.63990220
24FOXO3_23340844_ChIP-Seq_DLD1_Human1.63900072
25DROSHA_22980978_ChIP-Seq_HELA_Human1.61627085
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.61341370
27PPARA_22158963_ChIP-Seq_LIVER_Mouse1.60810900
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60495206
29FOXM1_26456572_ChIP-Seq_MCF-7_Human1.58393965
30TCF4_23295773_ChIP-Seq_U87_Human1.56468222
31TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.56228235
32STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.54655033
33TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.53760798
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.51854949
35TP53_16413492_ChIP-PET_HCT116_Human1.49816380
36SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49015312
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.48147286
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.47968581
39P300_19829295_ChIP-Seq_ESCs_Human1.46779332
40EZH2_27294783_Chip-Seq_NPCs_Mouse1.45256652
41* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.45096152
42TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.43493273
43NANOG_18555785_Chip-Seq_ESCs_Mouse1.43046375
44SUZ12_27294783_Chip-Seq_NPCs_Mouse1.42855402
45ESR1_20079471_ChIP-ChIP_T-47D_Human1.42658688
46VDR_22108803_ChIP-Seq_LS180_Human1.42406653
47NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.41731115
48NRF2_20460467_ChIP-Seq_MEFs_Mouse1.41731115
49NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.41372506
50FUS_26573619_Chip-Seq_HEK293_Human1.41118535
51EWS_26573619_Chip-Seq_HEK293_Human1.39883965
52CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.37964136
53AHR_22903824_ChIP-Seq_MCF-7_Human1.36987193
54UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.35386320
55PCGF2_27294783_Chip-Seq_ESCs_Mouse1.34290400
56CLOCK_20551151_ChIP-Seq_293T_Human1.33439426
57EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.33211051
58EP300_21415370_ChIP-Seq_HL-1_Mouse1.31874012
59FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.30574776
60AR_21572438_ChIP-Seq_LNCaP_Human1.30248568
61WT1_25993318_ChIP-Seq_PODOCYTE_Human1.29718855
62STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.29417098
63SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.29168354
64PPAR_26484153_Chip-Seq_NCI-H1993_Human1.27925508
65WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.27828252
66AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.27164287
67FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.26859294
68ARNT_22903824_ChIP-Seq_MCF-7_Human1.26499478
69NFE2_27457419_Chip-Seq_LIVER_Mouse1.26243225
70CTNNB1_20460455_ChIP-Seq_HCT116_Human1.25797424
71BCAT_22108803_ChIP-Seq_LS180_Human1.25535298
72E2F1_18555785_Chip-Seq_ESCs_Mouse1.25525275
73PIAS1_25552417_ChIP-Seq_VCAP_Human1.25269187
74MTF2_20144788_ChIP-Seq_MESCs_Mouse1.25178184
75BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.23935182
76PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.23595117
77P53_22387025_ChIP-Seq_ESCs_Mouse1.22822022
78* FLI1_21867929_ChIP-Seq_TH2_Mouse1.22136228
79PRDM14_20953172_ChIP-Seq_ESCs_Human1.21726972
80CMYC_18555785_Chip-Seq_ESCs_Mouse1.20345622
81TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20074141
82PCGF2_27294783_Chip-Seq_NPCs_Mouse1.19756652
83ESR1_21235772_ChIP-Seq_MCF-7_Human1.19531472
84WT1_19549856_ChIP-ChIP_CCG9911_Human1.18553645
85OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18164036
86Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.16732841
87* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.16304514
88CDX2_22108803_ChIP-Seq_LS180_Human1.16278076
89GATA2_21666600_ChIP-Seq_HMVEC_Human1.16092379
90GATA1_19941826_ChIP-Seq_K562_Human1.14702545
91SOX9_24532713_ChIP-Seq_HFSC_Mouse1.13959460
92AR_25329375_ChIP-Seq_VCAP_Human1.13907345
93TP53_18474530_ChIP-ChIP_U2OS_Human1.13865011
94ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.13587127
95* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.13423839
96AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.13381206
97TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.13060471
98EZH2_18974828_ChIP-Seq_MESCs_Mouse1.12950976
99RNF2_18974828_ChIP-Seq_MESCs_Mouse1.12950976
100SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.12887085
101* CRX_20693478_ChIP-Seq_RETINA_Mouse1.12578845
102KDM2B_26808549_Chip-Seq_REH_Human1.11647060
103IRF8_22096565_ChIP-ChIP_GC-B_Human1.11178434
104RXR_22108803_ChIP-Seq_LS180_Human1.11177657
105SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10900070
106SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.09317942
107CBP_20019798_ChIP-Seq_JUKART_Human1.09299634
108IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.09299634
109TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09245370
110POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09245370
111CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.09239965
112* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.09195456
113SUZ12_18555785_Chip-Seq_ESCs_Mouse1.08738274
114EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.08439686
115NFIB_24661679_ChIP-Seq_LUNG_Mouse1.08243745
116* RUNX2_22187159_ChIP-Seq_PCA_Human1.08097983
117SMAD_19615063_ChIP-ChIP_OVARY_Human1.07801618
118KDM2B_26808549_Chip-Seq_K562_Human1.07392068
119CJUN_26792858_Chip-Seq_BT549_Human1.06655875
120STAT6_21828071_ChIP-Seq_BEAS2B_Human1.06474440
121ZNF274_21170338_ChIP-Seq_K562_Hela1.05913674
122* TCF4_22108803_ChIP-Seq_LS180_Human1.05518329
123P300_18555785_Chip-Seq_ESCs_Mouse1.03136551
124* STAT3_23295773_ChIP-Seq_U87_Human1.01646780
125SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.00031618
126TBX20_22080862_ChIP-Seq_HEART_Mouse0.99376530
127TBX20_22328084_ChIP-Seq_HEART_Mouse0.99376530
128SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.98724129
129NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.98363675
130FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.98304408
131* TP63_23658742_ChIP-Seq_EP156T_Human0.98078037
132SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.97896278
133P300_27058665_Chip-Seq_ZR-75-30cells_Human0.97371820
134* RARB_27405468_Chip-Seq_BRAIN_Mouse0.95461848
135PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.94370363
136SALL4_18804426_ChIP-ChIP_XEN_Mouse0.92993531
137VDR_24787735_ChIP-Seq_THP-1_Human0.92913293
138RUNX_20019798_ChIP-Seq_JUKART_Human0.92834715
139TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92572696
140STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.92500094
141PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.92462073
142FOXA1_25552417_ChIP-Seq_VCAP_Human0.92337125
143PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.91976321
144* SOX2_21211035_ChIP-Seq_LN229_Gbm0.91920135
145* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.91762201
146ISL1_27105846_Chip-Seq_CPCs_Mouse0.91421881
147SMAD3_21741376_ChIP-Seq_EPCs_Human0.90884006
148FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.90722223
149NR3C1_23031785_ChIP-Seq_PC12_Mouse0.89734873
150NR3C1_21868756_ChIP-Seq_MCF10A_Human0.88193853
151RNF2_27304074_Chip-Seq_ESCs_Mouse0.88052245
152JARID2_20064375_ChIP-Seq_MESCs_Mouse0.87648327
153FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.87330564
154KDM2B_26808549_Chip-Seq_SUP-B15_Human0.86825517
155EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.86721923
156SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.85595430
157GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84468145
158KDM2B_26808549_Chip-Seq_DND41_Human0.84333094
159CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.83909219

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.89527018
2MP0002009_preneoplasia4.60632263
3MP0000920_abnormal_myelination3.61182140
4MP0008438_abnormal_cutaneous_collagen3.56455289
5MP0003690_abnormal_glial_cell3.03764105
6MP0002139_abnormal_hepatobiliary_system2.92310045
7MP0005360_urolithiasis2.65673790
8MP0004185_abnormal_adipocyte_glucose2.41364470
9MP0003950_abnormal_plasma_membrane2.38816948
10MP0003329_amyloid_beta_deposits2.37442180
11MP0005058_abnormal_lysosome_morphology2.35963996
12MP0003252_abnormal_bile_duct2.28365354
13MP0002166_altered_tumor_susceptibility2.28153703
14MP0009840_abnormal_foam_cell2.24044930
15MP0005365_abnormal_bile_salt2.17034311
16MP0004885_abnormal_endolymph2.16556656
17MP0000604_amyloidosis2.16239037
18MP0009780_abnormal_chondrocyte_physiolo2.11346852
19MP0003705_abnormal_hypodermis_morpholog2.08646334
20MP0003300_gastrointestinal_ulcer2.08150054
21MP0003890_abnormal_embryonic-extraembry2.02209346
22MP0005085_abnormal_gallbladder_physiolo1.98867582
23MP0010678_abnormal_skin_adnexa1.96906722
24MP0005310_abnormal_salivary_gland1.88304795
25MP0004270_analgesia1.82267577
26MP0000015_abnormal_ear_pigmentation1.80317587
27MP0001299_abnormal_eye_distance/1.72169462
28MP0008961_abnormal_basal_metabolism1.71820267
29MP0009384_cardiac_valve_regurgitation1.69627224
30MP0005451_abnormal_body_composition1.67948944
31MP0006054_spinal_hemorrhage1.62840209
32MP0005275_abnormal_skin_tensile1.61277229
33MP0003183_abnormal_peptide_metabolism1.60565608
34MP0001666_abnormal_nutrient_absorption1.59654823
35MP0003191_abnormal_cellular_cholesterol1.59414694
36MP0003634_abnormal_glial_cell1.59386654
37MP0003763_abnormal_thymus_physiology1.58770846
38MP0004130_abnormal_muscle_cell1.58641003
39MP0010352_gastrointestinal_tract_polyps1.56809241
40MP0003632_abnormal_nervous_system1.54896344
41MP0000569_abnormal_digit_pigmentation1.54208912
42MP0003195_calcinosis1.47234691
43MP0004272_abnormal_basement_membrane1.46875415
44MP0010234_abnormal_vibrissa_follicle1.46680182
45MP0005666_abnormal_adipose_tissue1.46641233
46MP0005409_darkened_coat_color1.45312205
47MP0002006_tumorigenesis1.44183869
48MP0002118_abnormal_lipid_homeostasis1.43619114
49MP0000371_diluted_coat_color1.42969902
50MP0005375_adipose_tissue_phenotype1.42845537
51MP0005623_abnormal_meninges_morphology1.42397256
52MP0003045_fibrosis1.41882220
53MP0010329_abnormal_lipoprotein_level1.41522442
54MP0008875_abnormal_xenobiotic_pharmacok1.40376685
55MP0002295_abnormal_pulmonary_circulatio1.35733820
56MP0000003_abnormal_adipose_tissue1.35568438
57MP0005187_abnormal_penis_morphology1.35525499
58MP0001501_abnormal_sleep_pattern1.35235559
59MP0003172_abnormal_lysosome_physiology1.35233717
60MP0000383_abnormal_hair_follicle1.33727458
61MP0000462_abnormal_digestive_system1.31158868
62MP0000747_muscle_weakness1.29252312
63MP0001958_emphysema1.28456460
64MP0003091_abnormal_cell_migration1.25216413
65MP0010386_abnormal_urinary_bladder1.24125900
66MP0004134_abnormal_chest_morphology1.21340465
67MP0003868_abnormal_feces_composition1.17327688
68MP0004859_abnormal_synaptic_plasticity1.16951285
69MP0005083_abnormal_biliary_tract1.15506777
70MP0004264_abnormal_extraembryonic_tissu1.13357571
71MP0001661_extended_life_span1.10983474
72MP0004484_altered_response_of1.10211664
73MP0000733_abnormal_muscle_development1.09663883
74MP0003631_nervous_system_phenotype1.07202421
75MP0003633_abnormal_nervous_system1.06993361
76MP0009703_decreased_birth_body1.04191581
77MP0005332_abnormal_amino_acid1.03543788
78MP0005174_abnormal_tail_pigmentation1.01733073
79MP0003075_altered_response_to1.01088442
80MP0003303_peritoneal_inflammation1.00174000
81MP0004808_abnormal_hematopoietic_stem0.96695351
82MP0000609_abnormal_liver_physiology0.95909110
83MP0003806_abnormal_nucleotide_metabolis0.95829726
84MP0005248_abnormal_Harderian_gland0.95413726
85MP0005220_abnormal_exocrine_pancreas0.95399443
86MP0004883_abnormal_blood_vessel0.94384260
87MP0005076_abnormal_cell_differentiation0.94177302
88MP0000538_abnormal_urinary_bladder0.93191584
89MP0000579_abnormal_nail_morphology0.92542735
90MP0004043_abnormal_pH_regulation0.92540411
91MP0003943_abnormal_hepatobiliary_system0.92414168
92MP0002168_other_aberrant_phenotype0.92269934
93MP0002896_abnormal_bone_mineralization0.91648598
94MP0005164_abnormal_response_to0.90825577
95MP0002229_neurodegeneration0.90701249
96MP0002254_reproductive_system_inflammat0.89102969
97MP0002928_abnormal_bile_duct0.86566924
98MP0001177_atelectasis0.86295294
99MP0003453_abnormal_keratinocyte_physiol0.85840803
100MP0000647_abnormal_sebaceous_gland0.85498084
101MP0004742_abnormal_vestibular_system0.85014306
102MP0009115_abnormal_fat_cell0.83822497
103MP0002971_abnormal_brown_adipose0.83434526
104MP0003279_aneurysm0.83248981
105MP0003656_abnormal_erythrocyte_physiolo0.83097694
106MP0003566_abnormal_cell_adhesion0.82694182
107MP0001191_abnormal_skin_condition0.82152671
108MP0005386_behavior/neurological_phenoty0.81826554
109MP0004924_abnormal_behavior0.81826554
110MP0004381_abnormal_hair_follicle0.81648689
111MP0002876_abnormal_thyroid_physiology0.80362313
112MP0005408_hypopigmentation0.79922981
113MP0004215_abnormal_myocardial_fiber0.79770310
114MP0005388_respiratory_system_phenotype0.79518000
115MP0002133_abnormal_respiratory_system0.79518000
116MP0002060_abnormal_skin_morphology0.79413429
117MP0002095_abnormal_skin_pigmentation0.79324552
118MP0002108_abnormal_muscle_morphology0.78120843
119MP0001849_ear_inflammation0.77319796
120MP0005503_abnormal_tendon_morphology0.76417697
121MP0002396_abnormal_hematopoietic_system0.76238212
122MP0002115_abnormal_skeleton_extremities0.75339060
123MP0005551_abnormal_eye_electrophysiolog0.73399859
124MP0002090_abnormal_vision0.72879076
125MP0000778_abnormal_nervous_system0.72643399
126MP0000013_abnormal_adipose_tissue0.72202823
127MP0001879_abnormal_lymphatic_vessel0.71993715
128MP0008877_abnormal_DNA_methylation0.71736925
129MP0005171_absent_coat_pigmentation0.70565333
130MP0001486_abnormal_startle_reflex0.69390844
131MP0001756_abnormal_urination0.68939301
132MP0000631_abnormal_neuroendocrine_gland0.68670858
133MP0006082_CNS_inflammation0.66299350
134MP0001851_eye_inflammation0.65355789
135MP0004087_abnormal_muscle_fiber0.65257036
136MP0005584_abnormal_enzyme/coenzyme_acti0.64989333
137MP0004036_abnormal_muscle_relaxation0.63828820
138MP0005647_abnormal_sex_gland0.62807289
139MP0001346_abnormal_lacrimal_gland0.62726656
140MP0005334_abnormal_fat_pad0.62379437
141MP0002075_abnormal_coat/hair_pigmentati0.61943520
142MP0002998_abnormal_bone_remodeling0.61634395
143MP0009046_muscle_twitch0.61044229
144MP0010368_abnormal_lymphatic_system0.60967126
145MP0003828_pulmonary_edema0.60321433
146MP0005670_abnormal_white_adipose0.59925052
147MP0000751_myopathy0.59817159
148MP0001784_abnormal_fluid_regulation0.59394625
149MP0000767_abnormal_smooth_muscle0.59149782
150MP0000639_abnormal_adrenal_gland0.58491370
151MP0000427_abnormal_hair_cycle0.58315582
152MP0005075_abnormal_melanosome_morpholog0.58002924
153MP0001270_distended_abdomen0.55338627
154MP0005395_other_phenotype0.54491592
155MP0003787_abnormal_imprinting0.54380969
156MP0010155_abnormal_intestine_physiology0.53613003

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)4.87901288
2Papillary thyroid carcinoma (HP:0002895)4.31697808
3Cerebral inclusion bodies (HP:0100314)4.23554542
4Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.85523436
5Degeneration of the lateral corticospinal tracts (HP:0002314)3.85523436
6Deep venous thrombosis (HP:0002625)3.20180347
7Abnormality of the corticospinal tract (HP:0002492)3.18647416
8Volvulus (HP:0002580)3.12188275
9Genetic anticipation (HP:0003743)3.06791595
10Insidious onset (HP:0003587)3.06575742
11Termporal pattern (HP:0011008)3.06575742
12Premature rupture of membranes (HP:0001788)2.93788597
13Gaze-evoked nystagmus (HP:0000640)2.93327499
14Intrahepatic cholestasis (HP:0001406)2.92859419
15Supranuclear gaze palsy (HP:0000605)2.89103015
16Xanthomatosis (HP:0000991)2.87288845
17Widely spaced teeth (HP:0000687)2.83805279
18Abnormality of the renal cortex (HP:0011035)2.83531997
19Broad metatarsal (HP:0001783)2.75898228
20Hyperventilation (HP:0002883)2.72574567
21Onion bulb formation (HP:0003383)2.70489182
22Narrow palate (HP:0000189)2.69276787
23Turricephaly (HP:0000262)2.67240004
24Thyroid carcinoma (HP:0002890)2.66106363
25Complement deficiency (HP:0004431)2.60254542
26Intention tremor (HP:0002080)2.56184354
27Hyporeflexia of lower limbs (HP:0002600)2.54049070
28Dysmetric saccades (HP:0000641)2.50224926
29Hyperlipoproteinemia (HP:0010980)2.46347454
30Premature skin wrinkling (HP:0100678)2.43197440
31Shallow orbits (HP:0000586)2.39332122
32Truncal obesity (HP:0001956)2.38143126
33Absent frontal sinuses (HP:0002688)2.37312794
34Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.36551071
35Infantile muscular hypotonia (HP:0008947)2.34374034
36Hypoplastic labia majora (HP:0000059)2.33361093
37Fair hair (HP:0002286)2.32012697
38Aplasia involving bones of the upper limbs (HP:0009823)2.31699333
39Aplasia of the phalanges of the hand (HP:0009802)2.31699333
40Aplasia involving bones of the extremities (HP:0009825)2.31699333
41Abnormality of the nasal septum (HP:0000419)2.30797797
42Sensory axonal neuropathy (HP:0003390)2.30359418
43Abnormality of aromatic amino acid family metabolism (HP:0004338)2.29026997
44Myocardial infarction (HP:0001658)2.28726843
45Difficulty running (HP:0009046)2.26715021
46Cerebral aneurysm (HP:0004944)2.25231473
47Macroorchidism (HP:0000053)2.25195833
48Hypoplastic ischia (HP:0003175)2.25046759
49Generalized hypopigmentation of hair (HP:0011358)2.22734297
50Ulnar bowing (HP:0003031)2.22636601
51Poor coordination (HP:0002370)2.21667948
52Vertebral arch anomaly (HP:0008438)2.20990476
53Chronic hepatic failure (HP:0100626)2.18323340
54Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)2.16903234
55Spastic gait (HP:0002064)2.15990432
56Abnormality of the labia majora (HP:0012881)2.13703762
57T lymphocytopenia (HP:0005403)2.10773763
58Dysmetria (HP:0001310)2.10693170
59Abnormality of the ischium (HP:0003174)2.08532745
60Buphthalmos (HP:0000557)2.06873830
61Vascular tortuosity (HP:0004948)2.05249470
62Mitral valve prolapse (HP:0001634)2.04959639
63Abnormality of the Achilles tendon (HP:0005109)2.04534450
64Disproportionate tall stature (HP:0001519)2.03524754
65Arterial tortuosity (HP:0005116)2.03055273
66Febrile seizures (HP:0002373)2.01954410
67Absent speech (HP:0001344)2.01879817
68Aortic dissection (HP:0002647)2.01782062
69Low anterior hairline (HP:0000294)2.01688660
70Coronal craniosynostosis (HP:0004440)2.01409790
71Protruding tongue (HP:0010808)2.01155486
72Action tremor (HP:0002345)1.98696152
73Neuronal loss in central nervous system (HP:0002529)1.97909150
74Scapular winging (HP:0003691)1.96936598
75Progressive cerebellar ataxia (HP:0002073)1.95220333
76Achilles tendon contracture (HP:0001771)1.95153997
77Abnormality of the common coagulation pathway (HP:0010990)1.93811324
78Heterotopia (HP:0002282)1.93462064
79Epidermoid cyst (HP:0200040)1.92775678
80Nephrogenic diabetes insipidus (HP:0009806)1.92525057
81Hematochezia (HP:0002573)1.91875956
82Overgrowth (HP:0001548)1.91756382
83Axonal loss (HP:0003447)1.90833267
84Tapered finger (HP:0001182)1.90749930
85Abnormality of incisor morphology (HP:0011063)1.90514526
86Hypoalphalipoproteinemia (HP:0003233)1.88427654
87Tubulointerstitial abnormality (HP:0001969)1.88198271
88Osteolytic defects of the hand bones (HP:0009699)1.87442064
89Osteolytic defects of the phalanges of the hand (HP:0009771)1.87442064
90Curly hair (HP:0002212)1.87128843
91Mitral stenosis (HP:0001718)1.86506521
92Thick eyebrow (HP:0000574)1.86163037
93Sandal gap (HP:0001852)1.85525301
94Hammertoe (HP:0001765)1.85357006
95Acute myeloid leukemia (HP:0004808)1.84911588
96Aortic aneurysm (HP:0004942)1.84885898
97Thickened calvaria (HP:0002684)1.84619164
98Relative macrocephaly (HP:0004482)1.84369672
99Thyroiditis (HP:0100646)1.84225375
100Tubulointerstitial nephritis (HP:0001970)1.83546493
101Abnormality of the fingertips (HP:0001211)1.83316723
102Abnormality of the epiphyses of the hand (HP:0005924)1.82539561
103Pheochromocytoma (HP:0002666)1.82316566
104Abnormal biliary tract morphology (HP:0012440)1.82115032
105Stridor (HP:0010307)1.82062045
106Abnormality of T cell number (HP:0011839)1.81983877
107Drooling (HP:0002307)1.81186260
108Long clavicles (HP:0000890)1.80898255
109Thick nail (HP:0001805)1.79838155
110Blue irides (HP:0000635)1.79339278
111Arthropathy (HP:0003040)1.78533004
112Spontaneous hematomas (HP:0007420)1.78067327
113Slow saccadic eye movements (HP:0000514)1.77984650
114Thickened helices (HP:0000391)1.77951640
115Peripheral demyelination (HP:0011096)1.77888378
116Periodontitis (HP:0000704)1.77124731
117Neoplasm of the heart (HP:0100544)1.76994702
118Bell-shaped thorax (HP:0001591)1.76860471
119Protuberant abdomen (HP:0001538)1.76633584
120Bronchomalacia (HP:0002780)1.76099901
121Medial flaring of the eyebrow (HP:0010747)1.75704027
122Congenital primary aphakia (HP:0007707)1.75615909
123Muscle fiber splitting (HP:0003555)1.75326767
124Hypokalemic alkalosis (HP:0001949)1.75278370
125Tubulointerstitial fibrosis (HP:0005576)1.75198740
126Skin nodule (HP:0200036)1.75192550
127Protrusio acetabuli (HP:0003179)1.74453936
128Short chin (HP:0000331)1.73872755
129Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.73822480
130Anteriorly placed anus (HP:0001545)1.73118786
131Global brain atrophy (HP:0002283)1.72685122
132Metabolic alkalosis (HP:0200114)1.72115585
133Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.71434604
134Gait imbalance (HP:0002141)1.71122665
135Coarse hair (HP:0002208)1.70675198
136Short foot (HP:0001773)1.70043717
137Excessive salivation (HP:0003781)1.69928295
138Alacrima (HP:0000522)1.69010813
139Spastic tetraparesis (HP:0001285)1.68705958
140Tented upper lip vermilion (HP:0010804)1.68422675
141Hypophosphatemic rickets (HP:0004912)1.68313928
142Cerebral hemorrhage (HP:0001342)1.68127666
143Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.67800747
144Upper limb amyotrophy (HP:0009129)1.67711137
145Distal upper limb amyotrophy (HP:0007149)1.67711137
146Abnormality of the renal medulla (HP:0100957)1.67629145
147Renal cortical cysts (HP:0000803)1.67210049
148Acanthocytosis (HP:0001927)1.67025573
149Wormian bones (HP:0002645)1.66903518
150Lower limb muscle weakness (HP:0007340)1.65907309
151Aplasia/Hypoplasia of the tibia (HP:0005772)1.65709790
152Abnormality of chloride homeostasis (HP:0011422)1.65037926
153Impaired vibratory sensation (HP:0002495)1.65005396
154Papilledema (HP:0001085)1.63592922
155Scanning speech (HP:0002168)1.63373517
156Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.62231029
157Hypoplasia of the iris (HP:0007676)1.62042427
158Aneurysm (HP:0002617)1.61903498
159Abnormality of complement system (HP:0005339)1.61755206
160Clumsiness (HP:0002312)1.61443546
161Peritonitis (HP:0002586)1.60985373
162Hemorrhage of the eye (HP:0011885)1.60245522
163Round face (HP:0000311)1.59371531
164Atrophic scars (HP:0001075)1.59234802
165Postural instability (HP:0002172)1.59181799
166Subacute progressive viral hepatitis (HP:0006572)1.58829681
167Akinesia (HP:0002304)1.58316950
168Abnormal foot bone ossification (HP:0010675)1.58252149
169Dyskinesia (HP:0100660)1.58189689
170Urinary urgency (HP:0000012)1.58043216
171Hip dysplasia (HP:0001385)1.57643942
172Dysdiadochokinesis (HP:0002075)1.57372012
173Broad palm (HP:0001169)1.57176069
174Menstrual irregularities (HP:0000858)1.57141919
175Increased cerebral lipofuscin (HP:0011813)1.57101736
176Broad ribs (HP:0000885)1.56362481
177Urethral obstruction (HP:0000796)1.55920168
178Dysostosis multiplex (HP:0000943)1.55781241
179Urinary bladder sphincter dysfunction (HP:0002839)1.55709573
180Chronic diarrhea (HP:0002028)1.55673525
181Hypolipoproteinemia (HP:0010981)1.55454009
182Focal segmental glomerulosclerosis (HP:0000097)1.54040265
183Amyloidosis (HP:0011034)1.53605054
184Epiphyseal dysplasia (HP:0002656)1.53269990
185Hyperextensible skin (HP:0000974)1.53202919
186Retinal atrophy (HP:0001105)1.52586706
187Recurrent bronchitis (HP:0002837)1.52133735
188Short 4th metacarpal (HP:0010044)1.51730990

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.06255431
2EPHB13.82816665
3FGFR22.62994387
4OXSR12.30092149
5LATS12.24761883
6SIK12.22142714
7CAMK1G2.19998611
8MET2.17157159
9ACVR1B2.07046226
10CAMKK21.98986224
11WNK11.96295343
12SGK21.90775973
13WNK41.77231089
14CAMK1D1.69459937
15ICK1.69298131
16NLK1.63472844
17PIK3CG1.62535703
18NTRK11.58089247
19PDGFRA1.50103259
20TRIB31.48519075
21DDR21.47899745
22PKN11.46899688
23BRD41.46300535
24PAK61.45858079
25PDGFRB1.45751573
26NTRK31.44873610
27TTN1.43616696
28PTK61.28237474
29NEK91.27719653
30DMPK1.25224538
31TYRO31.24861591
32FGR1.23721471
33EIF2AK31.22457757
34MAP3K21.20535655
35CASK1.19731602
36STK38L1.19327196
37TAOK31.18694102
38BMX1.17418407
39PRKCH1.17160259
40STK381.13950780
41BCR1.12502255
42BLK1.12364008
43PAK31.11618700
44YES11.11460855
45ERN11.09013339
46RET1.07568247
47CSNK1A1L1.06197821
48INSRR1.05107162
49ERBB31.02815337
50RIPK11.01567495
51KSR20.99948098
52MAP3K70.99892845
53EPHA30.98784910
54PRKD10.98724179
55ERBB40.98656942
56MAP3K130.97611317
57PNCK0.97437413
58BMPR20.97050690
59PRKD30.96034882
60PTK20.95606088
61MARK20.94946181
62MAPKAPK50.93138106
63PDPK10.93099074
64MAP3K60.92539271
65TXK0.92295988
66FGFR40.90524729
67SGK4940.90359386
68SGK2230.90359386
69KSR10.88625766
70FRK0.88175015
71BRSK20.88128684
72JAK10.87690154
73MAP3K140.87628427
74CAMK40.87265957
75TEC0.85857724
76EEF2K0.85792285
77MAPK130.85039285
78CDK60.84104577
79TGFBR20.83270707
80PAK20.80830769
81EPHA40.79633626
82PKN20.78799191
83CDK120.78012779
84ROCK20.77129616
85SGK30.75899712
86STK110.74970100
87CSNK1G20.74705009
88CLK10.72267579
89CSNK1G10.72095020
90BMPR1B0.71624407
91MTOR0.71404133
92IKBKE0.70686858
93PRKCQ0.70378554
94JAK30.70182715
95TYK20.70121837
96SCYL20.68874675
97PDK10.68318643
98MAP3K90.67946050
99PIK3CA0.66919611
100GSK3A0.66235237
101STK30.65660466
102CHUK0.65083580
103FER0.64988403
104FYN0.62403252
105JAK20.61978099
106RPS6KB10.61848839
107PRKAA10.61518347
108CSF1R0.61108558
109MELK0.60927534
110NUAK10.60898100
111CDK50.60388293
112HIPK20.59695251
113PRKAA20.58184422
114MAPK100.57977861
115PTK2B0.57639503
116PHKG10.57294570
117PHKG20.57294570
118CAMK2D0.56903202
119CSNK1D0.56681276
120UHMK10.55689790
121CSNK1G30.55524592
122DYRK1A0.55473184
123FGFR30.54486409
124MAPK70.54005868
125FGFR10.53894651
126CAMK2B0.52829743
127IRAK10.52693191
128TGFBR10.52527792
129CSK0.51165460
130CDK190.51132653
131INSR0.50086591
132PRKCE0.50033644
133WNK30.48204610
134NEK60.47429861
135DYRK1B0.46693119
136ZAP700.46515495
137PRKD20.45880425
138TRPM70.45364045
139ERBB20.45243233
140AKT30.44641289
141BTK0.44641015
142SGK10.44330048
143ITK0.44200978
144ALK0.44043149
145RAF10.44002452
146MAP3K40.43071538
147CDK30.42857579
148MAPK110.41255471
149MARK10.40071099
150TNK20.39122678
151MAP4K20.38948314
152CAMKK10.37316654
153SYK0.36876245
154CDC42BPA0.35822887
155CAMK10.35563949

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.27086320
2Steroid biosynthesis_Homo sapiens_hsa001002.33776215
3Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.11186545
4Circadian rhythm_Homo sapiens_hsa047101.86387833
5Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.81108921
6Fatty acid elongation_Homo sapiens_hsa000621.77622277
7Primary bile acid biosynthesis_Homo sapiens_hsa001201.67138273
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.56582491
9Butanoate metabolism_Homo sapiens_hsa006501.50213168
10Fatty acid metabolism_Homo sapiens_hsa012121.36272450
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.35545602
12Sulfur metabolism_Homo sapiens_hsa009201.35348349
13Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.32068892
14Arginine biosynthesis_Homo sapiens_hsa002201.31879268
15Bile secretion_Homo sapiens_hsa049761.21907653
16Ether lipid metabolism_Homo sapiens_hsa005651.21698487
17Complement and coagulation cascades_Homo sapiens_hsa046101.21639639
18Fatty acid degradation_Homo sapiens_hsa000711.18326621
19Dorso-ventral axis formation_Homo sapiens_hsa043201.17511370
20PPAR signaling pathway_Homo sapiens_hsa033201.16099038
21Histidine metabolism_Homo sapiens_hsa003401.15085561
22Renal cell carcinoma_Homo sapiens_hsa052111.14097136
23Longevity regulating pathway - mammal_Homo sapiens_hsa042111.13126026
24FoxO signaling pathway_Homo sapiens_hsa040681.11668761
25Taste transduction_Homo sapiens_hsa047421.06009701
26ABC transporters_Homo sapiens_hsa020101.04715080
27Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.04632421
28Lysine degradation_Homo sapiens_hsa003101.03800317
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.03216433
30Staphylococcus aureus infection_Homo sapiens_hsa051501.01479562
31Long-term potentiation_Homo sapiens_hsa047200.99476064
32Type II diabetes mellitus_Homo sapiens_hsa049300.99470792
33Jak-STAT signaling pathway_Homo sapiens_hsa046300.98829278
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.98767676
35Tryptophan metabolism_Homo sapiens_hsa003800.98160116
36Fat digestion and absorption_Homo sapiens_hsa049750.95635334
37Propanoate metabolism_Homo sapiens_hsa006400.95280485
38Thyroid hormone signaling pathway_Homo sapiens_hsa049190.95135176
39ECM-receptor interaction_Homo sapiens_hsa045120.93678210
40Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.93384080
41Prolactin signaling pathway_Homo sapiens_hsa049170.92430687
42Non-small cell lung cancer_Homo sapiens_hsa052230.92189218
43Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.92171975
44Axon guidance_Homo sapiens_hsa043600.91752398
45Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.91204756
46Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.91038796
47Fatty acid biosynthesis_Homo sapiens_hsa000610.89942857
48AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.89096033
49Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.86740243
50T cell receptor signaling pathway_Homo sapiens_hsa046600.86520222
51Selenocompound metabolism_Homo sapiens_hsa004500.85597147
52Cholinergic synapse_Homo sapiens_hsa047250.85515878
53Focal adhesion_Homo sapiens_hsa045100.84888232
54Amphetamine addiction_Homo sapiens_hsa050310.82630018
55Endometrial cancer_Homo sapiens_hsa052130.82437324
56Phospholipase D signaling pathway_Homo sapiens_hsa040720.81149390
57Lysosome_Homo sapiens_hsa041420.79796940
58Glycerolipid metabolism_Homo sapiens_hsa005610.78153694
59Insulin resistance_Homo sapiens_hsa049310.78007815
60Chronic myeloid leukemia_Homo sapiens_hsa052200.77216392
61NOD-like receptor signaling pathway_Homo sapiens_hsa046210.76751093
62Protein digestion and absorption_Homo sapiens_hsa049740.76350429
63MicroRNAs in cancer_Homo sapiens_hsa052060.74811149
64B cell receptor signaling pathway_Homo sapiens_hsa046620.74218113
65Caffeine metabolism_Homo sapiens_hsa002320.73795322
66cAMP signaling pathway_Homo sapiens_hsa040240.73060470
67Pancreatic secretion_Homo sapiens_hsa049720.72767267
68Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72513539
69Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.72227243
70Adipocytokine signaling pathway_Homo sapiens_hsa049200.71594420
71Circadian entrainment_Homo sapiens_hsa047130.71271146
72Steroid hormone biosynthesis_Homo sapiens_hsa001400.70229315
73TGF-beta signaling pathway_Homo sapiens_hsa043500.70192524
74Sphingolipid metabolism_Homo sapiens_hsa006000.70037093
75Calcium signaling pathway_Homo sapiens_hsa040200.69790886
76ErbB signaling pathway_Homo sapiens_hsa040120.69636765
77Amoebiasis_Homo sapiens_hsa051460.69437577
78Oxytocin signaling pathway_Homo sapiens_hsa049210.69395985
79Linoleic acid metabolism_Homo sapiens_hsa005910.68132700
80Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67736796
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66852025
82Small cell lung cancer_Homo sapiens_hsa052220.66510273
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.66010434
84Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65999951
85Salivary secretion_Homo sapiens_hsa049700.65856841
86Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.64820808
87Insulin secretion_Homo sapiens_hsa049110.64351121
88Endocytosis_Homo sapiens_hsa041440.64196473
89Renin secretion_Homo sapiens_hsa049240.63902343
90Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63545162
91Glioma_Homo sapiens_hsa052140.63339849
92Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63151154
93Choline metabolism in cancer_Homo sapiens_hsa052310.62969458
94Serotonergic synapse_Homo sapiens_hsa047260.62949414
95Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.62509274
96Osteoclast differentiation_Homo sapiens_hsa043800.62386988
97Dopaminergic synapse_Homo sapiens_hsa047280.62370219
98Tight junction_Homo sapiens_hsa045300.62201358
99Vascular smooth muscle contraction_Homo sapiens_hsa042700.62126613
100Proteoglycans in cancer_Homo sapiens_hsa052050.61280559
101Hepatitis C_Homo sapiens_hsa051600.61054208
102Gastric acid secretion_Homo sapiens_hsa049710.60927683
103Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60873399
104Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60396194
105alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.59713846
106Long-term depression_Homo sapiens_hsa047300.58840433
107Sphingolipid signaling pathway_Homo sapiens_hsa040710.58548000
108AMPK signaling pathway_Homo sapiens_hsa041520.58424164
109Glucagon signaling pathway_Homo sapiens_hsa049220.58071958
110Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.57788913
111Estrogen signaling pathway_Homo sapiens_hsa049150.57716201
112Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.57141611
113Glutamatergic synapse_Homo sapiens_hsa047240.56101647
114Peroxisome_Homo sapiens_hsa041460.55925421
115Prostate cancer_Homo sapiens_hsa052150.55459667
116Prion diseases_Homo sapiens_hsa050200.55089949
117Measles_Homo sapiens_hsa051620.54918024
118Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54858393
119TNF signaling pathway_Homo sapiens_hsa046680.54225293
120Glycerophospholipid metabolism_Homo sapiens_hsa005640.54210437
121Acute myeloid leukemia_Homo sapiens_hsa052210.53693800
122VEGF signaling pathway_Homo sapiens_hsa043700.53685520
123Renin-angiotensin system_Homo sapiens_hsa046140.53063327
124Dilated cardiomyopathy_Homo sapiens_hsa054140.51581046
125Toxoplasmosis_Homo sapiens_hsa051450.51267543
126Vitamin B6 metabolism_Homo sapiens_hsa007500.51212335
127Hepatitis B_Homo sapiens_hsa051610.51014847
128Colorectal cancer_Homo sapiens_hsa052100.50998440
129Maturity onset diabetes of the young_Homo sapiens_hsa049500.50889581
130Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50413818
131GABAergic synapse_Homo sapiens_hsa047270.50338096
132Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.50131105
133beta-Alanine metabolism_Homo sapiens_hsa004100.49150442
134Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.48654859
135Ovarian steroidogenesis_Homo sapiens_hsa049130.48614426
136Starch and sucrose metabolism_Homo sapiens_hsa005000.48604280
137Leukocyte transendothelial migration_Homo sapiens_hsa046700.47393007
138Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46995313
139Pancreatic cancer_Homo sapiens_hsa052120.46937818
140Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.46868437
141cGMP-PKG signaling pathway_Homo sapiens_hsa040220.46820466
142Thyroid hormone synthesis_Homo sapiens_hsa049180.46549439
143Aldosterone synthesis and secretion_Homo sapiens_hsa049250.46423948
144Ras signaling pathway_Homo sapiens_hsa040140.46026166
145Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.45157149
146GnRH signaling pathway_Homo sapiens_hsa049120.44898499
147Platelet activation_Homo sapiens_hsa046110.44245639
148Adherens junction_Homo sapiens_hsa045200.44153122
149Inositol phosphate metabolism_Homo sapiens_hsa005620.43855866
150mTOR signaling pathway_Homo sapiens_hsa041500.43357468
151Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.42953034

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