MOG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is a primary target antigen involved in immune-mediated demyelination. This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication. Alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)8.70437879
2synaptic vesicle maturation (GO:0016188)7.30986363
3ensheathment of neurons (GO:0007272)7.19599339
4axon ensheathment (GO:0008366)7.19599339
5myelination (GO:0042552)7.16314829
6synaptic vesicle docking involved in exocytosis (GO:0016081)7.02185772
7glutamate secretion (GO:0014047)6.63321762
8long-chain fatty acid biosynthetic process (GO:0042759)6.52505867
9synaptic vesicle exocytosis (GO:0016079)6.10355778
10cellular potassium ion homeostasis (GO:0030007)5.80186022
11regulation of short-term neuronal synaptic plasticity (GO:0048172)5.68333096
12membrane depolarization during cardiac muscle cell action potential (GO:0086012)5.64644972
13cholesterol biosynthetic process (GO:0006695)5.63358687
14regulation of synaptic vesicle exocytosis (GO:2000300)5.61076989
15myelin maintenance (GO:0043217)5.47937354
16sodium ion export (GO:0071436)5.24615345
17positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.20022001
18sterol biosynthetic process (GO:0016126)4.98565165
19neurotransmitter secretion (GO:0007269)4.95781496
20establishment of mitochondrion localization (GO:0051654)4.92521498
21negative regulation of synaptic transmission, GABAergic (GO:0032229)4.89219181
22negative regulation of neurotransmitter secretion (GO:0046929)4.87089396
23regulation of synaptic vesicle transport (GO:1902803)4.86050456
24neuronal ion channel clustering (GO:0045161)4.85780090
25negative regulation of protein localization to cell surface (GO:2000009)4.77219229
26regulation of neuronal synaptic plasticity (GO:0048168)4.76547618
27locomotory exploration behavior (GO:0035641)4.71718911
28negative regulation of neurotransmitter transport (GO:0051589)4.71108670
29neuronal action potential propagation (GO:0019227)4.67576454
30oligodendrocyte differentiation (GO:0048709)4.63112483
31positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.57297773
32glycerophospholipid catabolic process (GO:0046475)4.57177754
33potassium ion import (GO:0010107)4.57153077
34regulation of collateral sprouting (GO:0048670)4.54306714
35potassium ion homeostasis (GO:0055075)4.53742368
36long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.52133367
37postsynaptic membrane organization (GO:0001941)4.50152062
38creatine metabolic process (GO:0006600)4.50066842
39isoprenoid biosynthetic process (GO:0008299)4.48432872
40positive regulation of oligodendrocyte differentiation (GO:0048714)4.37790685
41response to methylmercury (GO:0051597)4.29890999
42ionotropic glutamate receptor signaling pathway (GO:0035235)4.27471185
43amyloid precursor protein metabolic process (GO:0042982)4.25606352
44long-chain fatty-acyl-CoA metabolic process (GO:0035336)4.21788597
45vocalization behavior (GO:0071625)4.21129768
46cerebellar granule cell differentiation (GO:0021707)4.19107977
47neurotransmitter transport (GO:0006836)4.15730631
48regulation of long-term neuronal synaptic plasticity (GO:0048169)4.12605454
49apical protein localization (GO:0045176)4.09718554
50L-amino acid import (GO:0043092)4.07663398
51astrocyte development (GO:0014002)4.07601916
52regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.04678393
53response to redox state (GO:0051775)4.03581841
54presynaptic membrane organization (GO:0097090)4.02401340
55eye photoreceptor cell differentiation (GO:0001754)4.01583983
56photoreceptor cell differentiation (GO:0046530)4.01583983
57regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.95424552
58fatty-acyl-CoA biosynthetic process (GO:0046949)3.95340901
59cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.95320499
60regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.94411267
61positive regulation of synapse maturation (GO:0090129)3.93926626
62substantia nigra development (GO:0021762)3.91752979
63gamma-aminobutyric acid transport (GO:0015812)3.90887900
64asymmetric protein localization (GO:0008105)3.86837975
65response to lipoprotein particle (GO:0055094)3.85532766
66exploration behavior (GO:0035640)3.84657601
67synaptic transmission, glutamatergic (GO:0035249)3.82886132
68regulation of neurotransmitter levels (GO:0001505)3.80689481
69acidic amino acid transport (GO:0015800)3.80383318
70import into cell (GO:0098657)3.79735080
71fatty-acyl-CoA metabolic process (GO:0035337)3.77908195
72membrane tubulation (GO:0097320)3.77042834
73regulation of lipoprotein metabolic process (GO:0050746)3.74027803
74regulation of glutamate receptor signaling pathway (GO:1900449)3.70216433
75regulation of synaptic plasticity (GO:0048167)3.64794178
76regulation of neurotransmitter secretion (GO:0046928)3.64253040
77peptidyl-tyrosine autophosphorylation (GO:0038083)3.63321999
78GPI anchor biosynthetic process (GO:0006506)3.61991666
79neurotransmitter-gated ion channel clustering (GO:0072578)3.61584958
80regulation of excitatory postsynaptic membrane potential (GO:0060079)3.56613432
81positive regulation of membrane potential (GO:0045838)3.55791910
82regulation of neurotransmitter transport (GO:0051588)3.51364235
83GPI anchor metabolic process (GO:0006505)3.50515617
84long-term synaptic potentiation (GO:0060291)3.50377264
85protein palmitoylation (GO:0018345)3.50265682
86glutamate receptor signaling pathway (GO:0007215)3.49850990
87neuromuscular process controlling balance (GO:0050885)3.49739682
88cellular sodium ion homeostasis (GO:0006883)3.49202061
89presynaptic membrane assembly (GO:0097105)3.49080815
90neuron-neuron synaptic transmission (GO:0007270)3.48764853
91gamma-aminobutyric acid signaling pathway (GO:0007214)3.47674735
92positive regulation of dendritic spine development (GO:0060999)3.47073164
93regulation of voltage-gated calcium channel activity (GO:1901385)3.45841553
94virion attachment to host cell (GO:0019062)3.44435482
95adhesion of symbiont to host cell (GO:0044650)3.44435482
96regulation of synapse structural plasticity (GO:0051823)3.42300931
97magnesium ion transport (GO:0015693)3.41685121
98protein localization to synapse (GO:0035418)3.40707165
99L-glutamate transport (GO:0015813)3.38887694
100cerebellar Purkinje cell differentiation (GO:0021702)3.37753781
101very long-chain fatty acid metabolic process (GO:0000038)3.37404677
102cell communication by electrical coupling (GO:0010644)3.33067774
103proline transport (GO:0015824)3.29856786
104regulation of postsynaptic membrane potential (GO:0060078)3.28088752
105axon development (GO:0061564)3.26794523
106preassembly of GPI anchor in ER membrane (GO:0016254)3.23316739
107myelination in peripheral nervous system (GO:0022011)3.22945878
108peripheral nervous system axon ensheathment (GO:0032292)3.22945878
109glycosylceramide metabolic process (GO:0006677)3.22853410
110regulation of dendritic spine development (GO:0060998)3.22228397
111regulation of dendritic spine morphogenesis (GO:0061001)3.21686818
112neuron remodeling (GO:0016322)3.21278493
113synaptic vesicle endocytosis (GO:0048488)3.21244539
114negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.20059486
115regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.19019530
116acyl-CoA biosynthetic process (GO:0071616)3.17534569
117thioester biosynthetic process (GO:0035384)3.17534569
118protein neddylation (GO:0045116)3.17192626
119regulation of synapse maturation (GO:0090128)3.17146520
120positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.15949627
121adult walking behavior (GO:0007628)3.15484266
122regulation of vesicle fusion (GO:0031338)3.15377655
123membrane depolarization during action potential (GO:0086010)3.15020189
124amyloid precursor protein catabolic process (GO:0042987)3.12726043
125long-term memory (GO:0007616)3.12633294
126dendritic spine morphogenesis (GO:0060997)3.12570223
127astrocyte differentiation (GO:0048708)3.11281757
128regulation of synaptic transmission (GO:0050804)3.10793530
129neuromuscular process controlling posture (GO:0050884)3.09517991
130auditory behavior (GO:0031223)3.08646244
131regulation of ARF protein signal transduction (GO:0032012)3.06558958
132detection of calcium ion (GO:0005513)3.06450708
133limb bud formation (GO:0060174)3.04979216
134negative regulation of JUN kinase activity (GO:0043508)3.04330907
135negative regulation of axonogenesis (GO:0050771)3.03323336
136membrane depolarization (GO:0051899)3.03267322
137regulation of synaptic transmission, glutamatergic (GO:0051966)3.00354465
138synaptic transmission (GO:0007268)2.99609662
139negative regulation of dendrite morphogenesis (GO:0050774)2.98070707
140positive regulation of neurotransmitter transport (GO:0051590)2.96169111
141heme transport (GO:0015886)2.94397287
142iron coordination entity transport (GO:1901678)2.90095713
143amino acid import (GO:0043090)2.89664925
144peptidyl-cysteine modification (GO:0018198)2.86323109
145cerebral cortex radially oriented cell migration (GO:0021799)2.86165761
146L-phenylalanine catabolic process (GO:0006559)2.85353344
147erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.85353344
148organ growth (GO:0035265)2.84722298
149positive regulation of cellular amine metabolic process (GO:0033240)2.84606139
150glial cell development (GO:0021782)2.82377742
151negative regulation of execution phase of apoptosis (GO:1900118)2.82238050
152neurotransmitter uptake (GO:0001504)2.81644615
153positive regulation of glial cell differentiation (GO:0045687)2.79211370
154nucleotide transmembrane transport (GO:1901679)2.77743086
155detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.74252415
156detection of temperature stimulus involved in sensory perception (GO:0050961)2.74252415
157Golgi to endosome transport (GO:0006895)2.72943251
158positive regulation of pseudopodium assembly (GO:0031274)2.72043688
159positive regulation of action potential (GO:0045760)2.72012947
160cellular response to epinephrine stimulus (GO:0071872)2.68762815
161peripheral nervous system development (GO:0007422)2.68298464
162response to dietary excess (GO:0002021)2.67708029
163leukocyte migration involved in inflammatory response (GO:0002523)2.67217425
164negative regulation of acute inflammatory response (GO:0002674)2.64946129
165microtubule polymerization or depolymerization (GO:0031109)2.62579328
166mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.61611821
167neural nucleus development (GO:0048857)2.60337232
168nerve growth factor signaling pathway (GO:0038180)2.57984504
169response to lead ion (GO:0010288)2.57976264
170positive regulation of gliogenesis (GO:0014015)2.57286522
171transmission of nerve impulse (GO:0019226)2.55647961
172neuron cell-cell adhesion (GO:0007158)2.55579389
173positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.54613091
174mannosylation (GO:0097502)2.52872041
175glial cell differentiation (GO:0010001)2.51313791
176adhesion of symbiont to host (GO:0044406)2.49505232
177cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.48754033
178axon ensheathment in central nervous system (GO:0032291)12.6981115
179central nervous system myelination (GO:0022010)12.6981115

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.53683604
2GBX2_23144817_ChIP-Seq_PC3_Human3.31937742
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.27827934
4MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.95610942
5SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.82216983
6EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.51538000
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.50791164
8CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.46249161
9TAF15_26573619_Chip-Seq_HEK293_Human2.28046186
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.20719897
11OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.18395491
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.15818499
13EZH2_22144423_ChIP-Seq_EOC_Human2.11864559
14JARID2_20064375_ChIP-Seq_MESCs_Mouse2.07939091
15VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.05816024
16THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.03328257
17EZH2_27304074_Chip-Seq_ESCs_Mouse1.95720210
18ZFP57_27257070_Chip-Seq_ESCs_Mouse1.94262712
19ER_23166858_ChIP-Seq_MCF-7_Human1.91894261
20MTF2_20144788_ChIP-Seq_MESCs_Mouse1.89487707
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.86599973
22VDR_22108803_ChIP-Seq_LS180_Human1.85087113
23IKZF1_21737484_ChIP-ChIP_HCT116_Human1.82571139
24EZH2_18974828_ChIP-Seq_MESCs_Mouse1.82179198
25RNF2_18974828_ChIP-Seq_MESCs_Mouse1.82179198
26TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.81628658
27RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.81491249
28SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.80889896
29EED_16625203_ChIP-ChIP_MESCs_Mouse1.76122435
30* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.74689019
31SUZ12_27294783_Chip-Seq_ESCs_Mouse1.73402663
32AR_21572438_ChIP-Seq_LNCaP_Human1.71678035
33EZH2_27294783_Chip-Seq_ESCs_Mouse1.71627068
34SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.69518759
35SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.64811231
36CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.64546680
37DNAJC2_21179169_ChIP-ChIP_NT2_Human1.55048248
38CDX2_19796622_ChIP-Seq_MESCs_Mouse1.54477533
39JARID2_20075857_ChIP-Seq_MESCs_Mouse1.54273457
40PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.50833376
41POU3F2_20337985_ChIP-ChIP_501MEL_Human1.50009745
42* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.49958443
43SMAD3_21741376_ChIP-Seq_EPCs_Human1.49297236
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48270026
45RNF2_27304074_Chip-Seq_ESCs_Mouse1.47163416
46CBX2_27304074_Chip-Seq_ESCs_Mouse1.45175759
47PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.44725107
48RING1B_27294783_Chip-Seq_ESCs_Mouse1.42444654
49RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.41044390
50DROSHA_22980978_ChIP-Seq_HELA_Human1.39275213
51ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.37958298
52TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37462162
53PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.35541812
54KDM2B_26808549_Chip-Seq_K562_Human1.33804221
55NR3C1_23031785_ChIP-Seq_PC12_Mouse1.33152149
56CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.32531036
57TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.31768674
58GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30923617
59NRF2_20460467_ChIP-Seq_MEFs_Mouse1.29264013
60NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.29264013
61WT1_19549856_ChIP-ChIP_CCG9911_Human1.29171159
62GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.28900820
63BMI1_23680149_ChIP-Seq_NPCS_Mouse1.26724447
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.26693148
65FUS_26573619_Chip-Seq_HEK293_Human1.25457688
66EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.24821912
67LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22845104
68EOMES_21245162_ChIP-Seq_HESCs_Human1.20633858
69ERG_21242973_ChIP-ChIP_JURKAT_Human1.20046335
70P300_19829295_ChIP-Seq_ESCs_Human1.18980458
71* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.18906905
72PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18721102
73TAL1_26923725_Chip-Seq_HPCs_Mouse1.18466738
74CTBP2_25329375_ChIP-Seq_LNCAP_Human1.17766420
75RARB_27405468_Chip-Seq_BRAIN_Mouse1.17474447
76TET1_21490601_ChIP-Seq_MESCs_Mouse1.14599469
77AR_19668381_ChIP-Seq_PC3_Human1.14017783
78SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13926117
79EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.12845797
80ESR2_21235772_ChIP-Seq_MCF-7_Human1.12065148
81CMYC_18555785_Chip-Seq_ESCs_Mouse1.11988144
82SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.10738739
83* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.08922236
84ZFP281_27345836_Chip-Seq_ESCs_Mouse1.08072574
85SOX2_21211035_ChIP-Seq_LN229_Gbm1.07525862
86SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.07368688
87PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.07146479
88NANOG_18555785_Chip-Seq_ESCs_Mouse1.06077136
89FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.05945697
90GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05318475
91OCT4_19829295_ChIP-Seq_ESCs_Human1.05018604
92STAT3_23295773_ChIP-Seq_U87_Human1.04214420
93SMAD4_21799915_ChIP-Seq_A2780_Human1.03635163
94SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03034939
95SUZ12_18555785_Chip-Seq_ESCs_Mouse1.03026875
96* CTCF_27219007_Chip-Seq_Bcells_Human1.02753484
97EP300_21415370_ChIP-Seq_HL-1_Mouse1.02591821
98MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01927729
99PRDM14_20953172_ChIP-Seq_ESCs_Human1.01253953
100P300_18555785_Chip-Seq_ESCs_Mouse1.00915060
101RING1B_27294783_Chip-Seq_NPCs_Mouse1.00690425
102CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.00447010
103REST_21632747_ChIP-Seq_MESCs_Mouse0.98587175
104P53_22127205_ChIP-Seq_FIBROBLAST_Human0.98514402
105GATA1_26923725_Chip-Seq_HPCs_Mouse0.98333906
106AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.98186002
107ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.97716544
108MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97336503
109TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96455116
110RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.95108111
111NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.94856339
112UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94143940
113IRF1_19129219_ChIP-ChIP_H3396_Human0.94016647
114SMAD3_21741376_ChIP-Seq_ESCs_Human0.93662305
115TCF4_23295773_ChIP-Seq_U87_Human0.92557237
116TOP2B_26459242_ChIP-Seq_MCF-7_Human0.92379495
117* HTT_18923047_ChIP-ChIP_STHdh_Human0.92321298
118CTNNB1_20460455_ChIP-Seq_HCT116_Human0.92133003
119LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91583932
120EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.91508191
121WT1_25993318_ChIP-Seq_PODOCYTE_Human0.89860511
122TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.89839395
123SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.87747984
124RNF2_27304074_Chip-Seq_NSC_Mouse0.87464829
125* NANOG_19829295_ChIP-Seq_ESCs_Human0.87388225
126* SOX2_19829295_ChIP-Seq_ESCs_Human0.87388225
127TBL1_22424771_ChIP-Seq_293T_Human0.87289281
128ARNT_22903824_ChIP-Seq_MCF-7_Human0.85540699
129* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.85249559
130NR3C1_21868756_ChIP-Seq_MCF10A_Human0.85152145
131* DPY_21335234_ChIP-Seq_ESCs_Mouse0.84734944
132YAP1_20516196_ChIP-Seq_MESCs_Mouse0.84248447
133KDM2B_26808549_Chip-Seq_REH_Human0.84188308
134EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.83940028
135WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.83324562
136SMAD4_21741376_ChIP-Seq_HESCs_Human0.82713804
137POU5F1_16153702_ChIP-ChIP_HESCs_Human0.82569244
138REST_18959480_ChIP-ChIP_MESCs_Mouse0.82354967
139SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.82349365
140RUNX1_27457419_Chip-Seq_LIVER_Mouse0.81974810
141POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.81257519
142TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81257519
143EGR1_19032775_ChIP-ChIP_M12_Human0.80963563
144BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.80066656
145GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77779675
146SMAD4_21741376_ChIP-Seq_ESCs_Human0.76993306
147SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.75634506
148MYC_19915707_ChIP-ChIP_AK7_Human0.73021025
149KLF4_19829295_ChIP-Seq_ESCs_Human0.71383332
150CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.70693293

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0000920_abnormal_myelination5.67615382
2MP0003950_abnormal_plasma_membrane3.91240880
3MP0003880_abnormal_central_pattern3.69640209
4MP0004270_analgesia3.33712356
5MP0003690_abnormal_glial_cell3.13805441
6MP0001529_abnormal_vocalization3.06096693
7MP0003329_amyloid_beta_deposits2.91237654
8MP0004885_abnormal_endolymph2.66265178
9MP0001905_abnormal_dopamine_level2.59491344
10MP0003136_yellow_coat_color2.56214353
11MP0004742_abnormal_vestibular_system2.54501894
12MP0005171_absent_coat_pigmentation2.51240280
13MP0003806_abnormal_nucleotide_metabolis2.46992937
14MP0002272_abnormal_nervous_system2.46031377
15MP0003634_abnormal_glial_cell2.45555035
16MP0001486_abnormal_startle_reflex2.40007223
17MP0001501_abnormal_sleep_pattern2.20369033
18MP0001485_abnormal_pinna_reflex2.19488636
19MP0005451_abnormal_body_composition2.17384903
20MP0005409_darkened_coat_color2.16699909
21MP0002064_seizures2.10600983
22MP0005410_abnormal_fertilization2.08950635
23MP0000778_abnormal_nervous_system2.08616013
24MP0003787_abnormal_imprinting1.99352553
25MP0002229_neurodegeneration1.94125961
26MP0003879_abnormal_hair_cell1.92952162
27MP0004043_abnormal_pH_regulation1.91668044
28MP0010678_abnormal_skin_adnexa1.89930598
29MP0005423_abnormal_somatic_nervous1.89763520
30MP0004859_abnormal_synaptic_plasticity1.75923754
31MP0005646_abnormal_pituitary_gland1.74742545
32MP0000383_abnormal_hair_follicle1.74062831
33MP0009780_abnormal_chondrocyte_physiolo1.73213478
34MP0001984_abnormal_olfaction1.68917769
35MP0001502_abnormal_circadian_rhythm1.68360273
36MP0000462_abnormal_digestive_system1.66352338
37MP0009046_muscle_twitch1.63848810
38MP0004811_abnormal_neuron_physiology1.61776774
39MP0002734_abnormal_mechanical_nocicepti1.60915874
40* MP0003632_abnormal_nervous_system1.60020483
41MP0000604_amyloidosis1.58136066
42* MP0004142_abnormal_muscle_tone1.57878872
43MP0009745_abnormal_behavioral_response1.54787620
44MP0004381_abnormal_hair_follicle1.54368023
45MP0004147_increased_porphyrin_level1.54131540
46MP0002557_abnormal_social/conspecific_i1.53317236
47MP0003635_abnormal_synaptic_transmissio1.46801685
48MP0004134_abnormal_chest_morphology1.46108097
49MP0005551_abnormal_eye_electrophysiolog1.43829995
50MP0005167_abnormal_blood-brain_barrier1.42645165
51* MP0003631_nervous_system_phenotype1.32649541
52MP0008260_abnormal_autophagy1.32399505
53MP0002882_abnormal_neuron_morphology1.29949765
54MP0003195_calcinosis1.26617091
55MP0003633_abnormal_nervous_system1.26049313
56* MP0000955_abnormal_spinal_cord1.23533773
57MP0005058_abnormal_lysosome_morphology1.21998027
58MP0001970_abnormal_pain_threshold1.21492408
59MP0001440_abnormal_grooming_behavior1.21104802
60MP0001963_abnormal_hearing_physiology1.20656097
61MP0000747_muscle_weakness1.19813686
62MP0002572_abnormal_emotion/affect_behav1.19775947
63* MP0002066_abnormal_motor_capabilities/c1.18486450
64MP0006276_abnormal_autonomic_nervous1.17427437
65MP0001661_extended_life_span1.15736475
66MP0008569_lethality_at_weaning1.12699874
67MP0005623_abnormal_meninges_morphology1.12111075
68MP0001346_abnormal_lacrimal_gland1.10901611
69MP0003075_altered_response_to1.10752827
70MP0003122_maternal_imprinting1.10495504
71MP0002295_abnormal_pulmonary_circulatio1.08981760
72MP0004924_abnormal_behavior1.08966202
73MP0005386_behavior/neurological_phenoty1.08966202
74MP0002822_catalepsy1.08468457
75MP0003123_paternal_imprinting1.08028985
76* MP0002752_abnormal_somatic_nervous1.07047521
77MP0001986_abnormal_taste_sensitivity1.06962830
78MP0002063_abnormal_learning/memory/cond1.05767777
79MP0001299_abnormal_eye_distance/1.05676346
80MP0001851_eye_inflammation1.04064758
81MP0008438_abnormal_cutaneous_collagen1.03280130
82MP0002067_abnormal_sensory_capabilities1.02722625
83MP0000647_abnormal_sebaceous_gland1.01710988
84MP0005408_hypopigmentation0.98957182
85* MP0005195_abnormal_posterior_eye0.96108846
86MP0000566_synostosis0.94714209
87MP0003938_abnormal_ear_development0.94297587
88MP0000762_abnormal_tongue_morphology0.93778021
89MP0002733_abnormal_thermal_nociception0.92742358
90MP0004185_abnormal_adipocyte_glucose0.90688922
91MP0001348_abnormal_lacrimal_gland0.88167805
92MP0008874_decreased_physiological_sensi0.86697047
93MP0002638_abnormal_pupillary_reflex0.84828550
94MP0008877_abnormal_DNA_methylation0.84740406
95MP0000579_abnormal_nail_morphology0.83550375
96MP0003937_abnormal_limbs/digits/tail_de0.81701945
97MP0003656_abnormal_erythrocyte_physiolo0.80296973
98MP0000026_abnormal_inner_ear0.76631182
99MP0006072_abnormal_retinal_apoptosis0.75947453
100MP0002152_abnormal_brain_morphology0.75861565
101MP0001177_atelectasis0.74860879
102MP0008872_abnormal_physiological_respon0.72746944
103MP0004145_abnormal_muscle_electrophysio0.72353732
104MP0002735_abnormal_chemical_nociception0.72242019
105MP0005253_abnormal_eye_physiology0.71821155
106MP0005535_abnormal_body_temperature0.70882521
107MP0009840_abnormal_foam_cell0.70730653
108MP0004036_abnormal_muscle_relaxation0.70091722
109MP0002069_abnormal_eating/drinking_beha0.68103904
110MP0002909_abnormal_adrenal_gland0.66467933
111MP0010386_abnormal_urinary_bladder0.64384267
112MP0000467_abnormal_esophagus_morphology0.64078967
113MP0003172_abnormal_lysosome_physiology0.62778241
114MP0001968_abnormal_touch/_nociception0.62632673
115MP0001727_abnormal_embryo_implantation0.60203291
116MP0001340_abnormal_eyelid_morphology0.60097819
117MP0003137_abnormal_impulse_conducting0.60074210
118MP0000372_irregular_coat_pigmentation0.59782560
119MP0000749_muscle_degeneration0.59610823
120MP0002090_abnormal_vision0.59455427
121MP0005645_abnormal_hypothalamus_physiol0.58248341
122MP0005388_respiratory_system_phenotype0.58007923
123MP0002133_abnormal_respiratory_system0.58007923
124MP0002184_abnormal_innervation0.57495576
125MP0002736_abnormal_nociception_after0.57081161
126MP0000569_abnormal_digit_pigmentation0.56307023
127MP0004215_abnormal_myocardial_fiber0.55896764
128MP0002938_white_spotting0.55144910
129MP0010769_abnormal_survival0.53249453
130MP0004130_abnormal_muscle_cell0.51599399
131MP0010768_mortality/aging0.50097735
132MP0010770_preweaning_lethality0.49510996
133MP0002082_postnatal_lethality0.49510996
134MP0003283_abnormal_digestive_organ0.49205846
135MP0002653_abnormal_ependyma_morphology0.48830609
136MP0000639_abnormal_adrenal_gland0.47720176
137MP0001943_abnormal_respiration0.45750449
138MP0003956_abnormal_body_size0.45517800
139MP0003121_genomic_imprinting0.45425850
140MP0000631_abnormal_neuroendocrine_gland0.42743041
141MP0005166_decreased_susceptibility_to0.42392091
142MP0002873_normal_phenotype0.41629354

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)7.04371132
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)7.04371132
3Focal motor seizures (HP:0011153)6.41033675
4Neurofibrillary tangles (HP:0002185)6.39698380
5Parakeratosis (HP:0001036)5.40516264
6Focal seizures (HP:0007359)5.38903667
7Action tremor (HP:0002345)5.27800015
8Abnormality of the corticospinal tract (HP:0002492)5.23951999
9Febrile seizures (HP:0002373)4.95885945
10Diplopia (HP:0000651)4.85069959
11Abnormality of binocular vision (HP:0011514)4.85069959
12Epileptic encephalopathy (HP:0200134)4.76699733
13Sensory axonal neuropathy (HP:0003390)4.67439014
14Cerebral inclusion bodies (HP:0100314)4.60183906
15Atonic seizures (HP:0010819)4.55642357
16Peripheral hypomyelination (HP:0007182)4.40570354
17Increased serum pyruvate (HP:0003542)4.20290656
18Abnormality of glycolysis (HP:0004366)4.20290656
19Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.14131171
20Cerebral hypomyelination (HP:0006808)3.92042802
21Onion bulb formation (HP:0003383)3.74637114
22Supranuclear gaze palsy (HP:0000605)3.73206982
23Abnormal eating behavior (HP:0100738)3.70210864
24Generalized tonic-clonic seizures (HP:0002069)3.66592250
25Spastic gait (HP:0002064)3.61723931
26Termporal pattern (HP:0011008)3.59680228
27Insidious onset (HP:0003587)3.59680228
28Progressive cerebellar ataxia (HP:0002073)3.44035661
29Limb dystonia (HP:0002451)3.41377041
30Urinary urgency (HP:0000012)3.36177791
31Postural instability (HP:0002172)3.29246919
32Visual hallucinations (HP:0002367)3.28354123
33Leukodystrophy (HP:0002415)3.28245221
34Abnormal auditory evoked potentials (HP:0006958)3.23057631
35Absence seizures (HP:0002121)3.19120732
36Dialeptic seizures (HP:0011146)3.16216061
37Mutism (HP:0002300)3.07735276
38Alacrima (HP:0000522)3.07042257
39Urinary bladder sphincter dysfunction (HP:0002839)3.04475690
40Congenital ichthyosiform erythroderma (HP:0007431)3.04243627
41Papilledema (HP:0001085)3.03424650
42Hemiplegia (HP:0002301)3.01303294
43Intention tremor (HP:0002080)3.00320387
44Dysmetria (HP:0001310)3.00258124
45Retinal dysplasia (HP:0007973)2.92777599
46Torticollis (HP:0000473)2.92429659
47Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.91450009
48Slow saccadic eye movements (HP:0000514)2.83356534
49Delusions (HP:0000746)2.79944716
50Hemiparesis (HP:0001269)2.78798184
51Obstructive sleep apnea (HP:0002870)2.78426567
52Dysdiadochokinesis (HP:0002075)2.75265287
53Scanning speech (HP:0002168)2.75159171
54Truncal ataxia (HP:0002078)2.70896667
55Tetraplegia (HP:0002445)2.69762931
56Status epilepticus (HP:0002133)2.66017501
57Stridor (HP:0010307)2.65974375
58Absent septum pellucidum (HP:0001331)2.63428041
59Abnormality of the periventricular white matter (HP:0002518)2.63186042
60Myokymia (HP:0002411)2.62044433
61Cerebral hemorrhage (HP:0001342)2.61400701
62Segmental peripheral demyelination/remyelination (HP:0003481)2.61241458
63Ankle clonus (HP:0011448)2.61232884
64Hypoplastic pelvis (HP:0008839)2.61044848
65Spastic paraparesis (HP:0002313)2.60384140
66Anteriorly placed anus (HP:0001545)2.59372075
67Annular pancreas (HP:0001734)2.55759619
68Anxiety (HP:0000739)2.55576608
69Neuronal loss in central nervous system (HP:0002529)2.53951574
70Sleep apnea (HP:0010535)2.52999407
71Autoamputation (HP:0001218)2.52499901
72Renal Fanconi syndrome (HP:0001994)2.52480745
73Rigidity (HP:0002063)2.52312773
74Impaired vibration sensation in the lower limbs (HP:0002166)2.52017864
75Thickened helices (HP:0000391)2.50367594
76CNS hypomyelination (HP:0003429)2.49705084
77Bradykinesia (HP:0002067)2.46488837
78Clumsiness (HP:0002312)2.44417736
79Focal dystonia (HP:0004373)2.43355077
80Premature skin wrinkling (HP:0100678)2.42137519
81Epileptiform EEG discharges (HP:0011182)2.41184859
82Depression (HP:0000716)2.40529509
83Akinesia (HP:0002304)2.39291460
84Decreased lacrimation (HP:0000633)2.33809296
85Insomnia (HP:0100785)2.31839348
86Poor eye contact (HP:0000817)2.31030234
87Hepatosplenomegaly (HP:0001433)2.29847142
88Increased circulating renin level (HP:0000848)2.28071311
89Morphological abnormality of the inner ear (HP:0011390)2.27681477
90Craniofacial dystonia (HP:0012179)2.26238845
91Rapidly progressive (HP:0003678)2.22048627
92Muscle fiber splitting (HP:0003555)2.21810927
93Abnormality of the septum pellucidum (HP:0007375)2.21751723
94Acute necrotizing encephalopathy (HP:0006965)2.21094612
95Split foot (HP:0001839)2.19014368
96Apathy (HP:0000741)2.18554786
97Methylmalonic acidemia (HP:0002912)2.18018060
98Infantile muscular hypotonia (HP:0008947)2.17915403
99Abnormality of the phalanges of the 2nd finger (HP:0009541)2.15461220
100Pheochromocytoma (HP:0002666)2.13784052
101EEG with generalized epileptiform discharges (HP:0011198)2.12569609
102Spastic tetraparesis (HP:0001285)2.11868173
103Metabolic alkalosis (HP:0200114)2.11138128
104Partial agenesis of the corpus callosum (HP:0001338)2.10787238
105Foot dorsiflexor weakness (HP:0009027)2.10152747
106Coronal craniosynostosis (HP:0004440)2.09725024
107Patchy hypopigmentation of hair (HP:0011365)2.07889753
108Lower limb muscle weakness (HP:0007340)2.07495770
109Polyphagia (HP:0002591)2.06973056
110White forelock (HP:0002211)2.03559508
111Impaired smooth pursuit (HP:0007772)2.01939957
112Axonal loss (HP:0003447)2.01462822
113Megalencephaly (HP:0001355)2.01020348
114Hypsarrhythmia (HP:0002521)2.00026699
1153-Methylglutaconic aciduria (HP:0003535)1.99567822
116Cupped ear (HP:0000378)1.98319207
117Aplasia involving bones of the upper limbs (HP:0009823)1.97977955
118Aplasia of the phalanges of the hand (HP:0009802)1.97977955
119Aplasia involving bones of the extremities (HP:0009825)1.97977955
120Erythroderma (HP:0001019)1.97924075
121Abnormality of aromatic amino acid family metabolism (HP:0004338)1.97626919
122Partial duplication of thumb phalanx (HP:0009944)1.97502110
123Hypophosphatemic rickets (HP:0004912)1.97317727
124Gaze-evoked nystagmus (HP:0000640)1.96625717
125Hypoplasia of the iris (HP:0007676)1.96244913
126Diminished motivation (HP:0000745)1.96115446
127Hypomagnesemia (HP:0002917)1.95836005
128Bundle branch block (HP:0011710)1.93476458
129Impaired social interactions (HP:0000735)1.92840595
130Abnormal social behavior (HP:0012433)1.92840595
131Decreased motor nerve conduction velocity (HP:0003431)1.92020803
132Amblyopia (HP:0000646)1.91350940
133Hypokalemic alkalosis (HP:0001949)1.90714137
134Acute encephalopathy (HP:0006846)1.90086272
135Broad-based gait (HP:0002136)1.89654132
136Abnormality of the foot musculature (HP:0001436)1.89439197
137Hyporeflexia of lower limbs (HP:0002600)1.88940422
138Duplicated collecting system (HP:0000081)1.88562632
139Neuroendocrine neoplasm (HP:0100634)1.88523980
140Abnormality of ocular smooth pursuit (HP:0000617)1.88219951
141Spastic paraplegia (HP:0001258)1.88007630
142Esophageal atresia (HP:0002032)1.87382447
143Abnormality of saccadic eye movements (HP:0000570)1.86380081
144Paraplegia (HP:0010550)1.85614162
145Bowel incontinence (HP:0002607)1.84958944
146Poor speech (HP:0002465)1.84536862
147Impaired vibratory sensation (HP:0002495)1.83655441
148Morphological abnormality of the pyramidal tract (HP:0002062)1.83285229
149Paraparesis (HP:0002385)1.82324368
150Abnormality of cochlea (HP:0000375)1.81598039
151Incomplete penetrance (HP:0003829)1.79878237
152Urinary incontinence (HP:0000020)1.79141020
153Stereotypic behavior (HP:0000733)1.77396118
154Synostosis involving the elbow (HP:0003938)1.76350073
155Humeroradial synostosis (HP:0003041)1.76350073
156Clonus (HP:0002169)1.76219110
157Mitochondrial inheritance (HP:0001427)1.75200254
158Progressive macrocephaly (HP:0004481)1.75104115
159Prolonged neonatal jaundice (HP:0006579)1.75052325
160Choreoathetosis (HP:0001266)1.74856487
161Abnormality of the middle phalanges of the toes (HP:0010183)1.74010802
162Abnormal mitochondria in muscle tissue (HP:0008316)1.73879450
163Hammertoe (HP:0001765)1.72398792
164Postnatal microcephaly (HP:0005484)1.71647675

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK396.42218860
2OXSR14.56588923
3NTRK34.13972613
4EPHB13.84107536
5DAPK23.34133166
6PBK2.86995392
7WNK42.84940246
8BCR2.80826351
9CDK192.70502701
10PKN12.69204696
11PRKD32.42533884
12MAPKAPK52.39521503
13MET2.36485554
14TESK22.32675985
15CAMKK12.14271734
16MINK12.11866493
17MAP3K92.06674537
18FGFR22.06535093
19LIMK12.06262409
20WNK12.06190753
21CSNK1G31.94521157
22CSNK1A1L1.88674851
23PNCK1.83577014
24MST41.82650634
25UHMK11.79438138
26PLK21.65827106
27CAMK2B1.61552126
28PINK11.57938835
29CSNK1G11.54157866
30NEK61.50458868
31CSNK1G21.44958578
32TNIK1.43400300
33ROCK21.42077314
34GRK51.42019021
35NTRK11.41871386
36FGR1.39515781
37ICK1.36523036
38CAMK2D1.34600968
39CLK11.33363566
40CAMK11.33319479
41PRKCG1.25152268
42RIPK41.20842862
43PRPF4B1.15706892
44ALK1.15299576
45RIPK11.14133791
46PAK61.13473215
47SGK2231.11553115
48SGK4941.11553115
49DYRK21.06446642
50DAPK11.05690574
51CAMK2G1.03595103
52SGK21.00055153
53SIK20.99920846
54CASK0.97987805
55CAMKK20.97597302
56EPHA40.96391653
57MAPK120.89715811
58ARAF0.89192641
59TYRO30.88784558
60MARK10.87932839
61MARK20.86978099
62LATS20.86453520
63CDK140.85578764
64PRKCQ0.85350757
65SGK10.83497853
66TNK20.83332372
67CAMK2A0.83124516
68MAPK100.81085947
69BMPR1B0.79058705
70SGK30.78701670
71MUSK0.77668871
72PRKD10.77476919
73CDK50.76809119
74CDK150.76372955
75MAPK150.74114859
76PAK30.72611561
77STK380.71560938
78CDK180.70587660
79CDK11A0.69118540
80PRKCZ0.66829868
81PDPK10.65620049
82ERBB40.64607798
83MAP3K130.63873398
84PRKCE0.63205737
85TRPM70.62068691
86RPS6KA30.61614925
87PHKG10.60570288
88PHKG20.60570288
89RPS6KA50.60569818
90BRSK10.60422180
91MAP3K40.58616454
92MAP3K110.56569079
93FES0.54750798
94FYN0.53792352
95LMTK20.53410059
96CAMK40.53337983
97CSNK1D0.51903312
98ILK0.49684551
99PRKG10.49372212
100CAMK1G0.47425299
101CSNK1A10.44802080
102PAK10.44122246
103GRK70.43650022
104IRAK20.43306713
105PRKCA0.43225567
106PRKACB0.42948624
107ROCK10.42295687
108GSK3A0.41482738
109PIK3CA0.38540480
110MAP2K20.37165041
111ADRBK20.36987682
112KSR20.36567720
113MAP2K40.36475476
114MAP2K70.35741471
115PRKCH0.34732303
116NTRK20.34716561
117MKNK10.34547023
118OBSCN0.34520927
119STK110.34430830
120ERBB20.34322976
121PRKG20.32992241
122DDR20.32226949
123BRAF0.30854821
124BLK0.30612899
125PRKCB0.30386766
126KSR10.30276547
127PTK2B0.29085334
128PDK10.28903919
129RAF10.28775436
130SRC0.28369746
131DAPK30.27974736
132PRKACA0.27485430
133MOS0.26941262
134MAP2K60.26019483
135ITK0.25906208
136INSR0.25234634
137MAPK70.24919228
138PDGFRB0.23872044
139BMX0.23347246
140CSNK1E0.23010483
141BMPR20.22556462
142DYRK1A0.22280621
143GRK10.21378414
144MAPK130.19400951
145LCK0.19300071
146ABL20.18608016

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.94934253
2Steroid biosynthesis_Homo sapiens_hsa001004.91022303
3Fatty acid elongation_Homo sapiens_hsa000624.80762922
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.97547849
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.14004025
6Ether lipid metabolism_Homo sapiens_hsa005653.02531564
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.77910053
8Insulin secretion_Homo sapiens_hsa049112.64102775
9Long-term potentiation_Homo sapiens_hsa047202.62629999
10Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.60761052
11Amphetamine addiction_Homo sapiens_hsa050312.55446407
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.30670331
13Oxidative phosphorylation_Homo sapiens_hsa001902.23254800
14Protein export_Homo sapiens_hsa030602.22289463
15Vitamin B6 metabolism_Homo sapiens_hsa007502.06875465
16Sulfur metabolism_Homo sapiens_hsa009201.99599718
17Histidine metabolism_Homo sapiens_hsa003401.88381290
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.77474346
19Sphingolipid metabolism_Homo sapiens_hsa006001.75384786
20Butanoate metabolism_Homo sapiens_hsa006501.74857304
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.72871507
22Linoleic acid metabolism_Homo sapiens_hsa005911.71699942
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.65966012
24Parkinsons disease_Homo sapiens_hsa050121.61366907
25alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.56135514
26Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.55657911
27Axon guidance_Homo sapiens_hsa043601.51375154
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.49725145
29Alzheimers disease_Homo sapiens_hsa050101.48184919
30Oxytocin signaling pathway_Homo sapiens_hsa049211.46560313
31cAMP signaling pathway_Homo sapiens_hsa040241.46494750
32Calcium signaling pathway_Homo sapiens_hsa040201.42886143
33Olfactory transduction_Homo sapiens_hsa047401.26353196
34Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.23713179
35Bile secretion_Homo sapiens_hsa049761.16930910
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.14774590
37Arginine and proline metabolism_Homo sapiens_hsa003301.13570890
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.11793777
39Estrogen signaling pathway_Homo sapiens_hsa049151.10775411
40Nitrogen metabolism_Homo sapiens_hsa009101.09821277
41GABAergic synapse_Homo sapiens_hsa047271.09522814
42Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.09493505
43Serotonergic synapse_Homo sapiens_hsa047261.06331246
44GnRH signaling pathway_Homo sapiens_hsa049121.05321616
45SNARE interactions in vesicular transport_Homo sapiens_hsa041301.02297277
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.02228967
47Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.01408820
48cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98221700
49Glutamatergic synapse_Homo sapiens_hsa047240.98162049
50Fatty acid metabolism_Homo sapiens_hsa012120.93658919
51Renal cell carcinoma_Homo sapiens_hsa052110.93149223
52Gap junction_Homo sapiens_hsa045400.92893739
53Thyroid hormone synthesis_Homo sapiens_hsa049180.90223193
54Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.88280084
55Collecting duct acid secretion_Homo sapiens_hsa049660.87803642
56Propanoate metabolism_Homo sapiens_hsa006400.87380477
57Glutathione metabolism_Homo sapiens_hsa004800.86702473
58Arachidonic acid metabolism_Homo sapiens_hsa005900.85689910
59Vibrio cholerae infection_Homo sapiens_hsa051100.84972309
60Melanogenesis_Homo sapiens_hsa049160.83577850
61Huntingtons disease_Homo sapiens_hsa050160.81412633
62Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.81112375
63Morphine addiction_Homo sapiens_hsa050320.80635915
64Glioma_Homo sapiens_hsa052140.79896570
65Tight junction_Homo sapiens_hsa045300.78848565
66Sphingolipid signaling pathway_Homo sapiens_hsa040710.77860419
67Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77746305
68Cardiac muscle contraction_Homo sapiens_hsa042600.76098301
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75398482
70Inositol phosphate metabolism_Homo sapiens_hsa005620.73460143
71Oocyte meiosis_Homo sapiens_hsa041140.73332498
72Long-term depression_Homo sapiens_hsa047300.73232278
73Autoimmune thyroid disease_Homo sapiens_hsa053200.71584036
74Folate biosynthesis_Homo sapiens_hsa007900.70397642
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69098285
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.68848105
77Rheumatoid arthritis_Homo sapiens_hsa053230.67654630
78Rap1 signaling pathway_Homo sapiens_hsa040150.66532771
79Peroxisome_Homo sapiens_hsa041460.62622190
80Glycerophospholipid metabolism_Homo sapiens_hsa005640.62277466
81Lysosome_Homo sapiens_hsa041420.61654867
82Circadian rhythm_Homo sapiens_hsa047100.61232377
83Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60823441
84MAPK signaling pathway_Homo sapiens_hsa040100.60618019
85Phototransduction_Homo sapiens_hsa047440.60072588
86Cocaine addiction_Homo sapiens_hsa050300.58437436
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58255813
88Endocytosis_Homo sapiens_hsa041440.56251338
89Ovarian steroidogenesis_Homo sapiens_hsa049130.56119768
90Ras signaling pathway_Homo sapiens_hsa040140.56022626
91Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.54473326
92Vascular smooth muscle contraction_Homo sapiens_hsa042700.53134307
93Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52826704
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52583015
95Type II diabetes mellitus_Homo sapiens_hsa049300.52020396
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.51934405
97ABC transporters_Homo sapiens_hsa020100.51016757
98Metabolic pathways_Homo sapiens_hsa011000.50728817
99Mineral absorption_Homo sapiens_hsa049780.50232719
100Chemical carcinogenesis_Homo sapiens_hsa052040.47874742
101Circadian entrainment_Homo sapiens_hsa047130.47389250
102Choline metabolism in cancer_Homo sapiens_hsa052310.45458586
103Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.45188201
104Pyruvate metabolism_Homo sapiens_hsa006200.43967843
105Phagosome_Homo sapiens_hsa041450.43697418
106Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43376800
107Phospholipase D signaling pathway_Homo sapiens_hsa040720.42995322
108Regulation of autophagy_Homo sapiens_hsa041400.42556077
109Arginine biosynthesis_Homo sapiens_hsa002200.41309407
110Tyrosine metabolism_Homo sapiens_hsa003500.40939359
111Fatty acid biosynthesis_Homo sapiens_hsa000610.40698957
112VEGF signaling pathway_Homo sapiens_hsa043700.40693883
113Glucagon signaling pathway_Homo sapiens_hsa049220.40317879
114Salivary secretion_Homo sapiens_hsa049700.40042082
115Dorso-ventral axis formation_Homo sapiens_hsa043200.39673502
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38431978
117Vitamin digestion and absorption_Homo sapiens_hsa049770.37991131
118Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37314174
119Dopaminergic synapse_Homo sapiens_hsa047280.36456942
120Retinol metabolism_Homo sapiens_hsa008300.35381558
121ErbB signaling pathway_Homo sapiens_hsa040120.34846346
122Cholinergic synapse_Homo sapiens_hsa047250.34500850
123Gastric acid secretion_Homo sapiens_hsa049710.33993750
124Malaria_Homo sapiens_hsa051440.33785061
125Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.33175273
126Hedgehog signaling pathway_Homo sapiens_hsa043400.32095933
127Pancreatic secretion_Homo sapiens_hsa049720.31533536
128Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.31068834
129Nicotine addiction_Homo sapiens_hsa050330.30142018
130Dilated cardiomyopathy_Homo sapiens_hsa054140.26781170
131Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.26517300
132Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.26460730
133ECM-receptor interaction_Homo sapiens_hsa045120.26247367
134Regulation of actin cytoskeleton_Homo sapiens_hsa048100.25238547
135Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.23964432
136Synaptic vesicle cycle_Homo sapiens_hsa047210.23629597
137beta-Alanine metabolism_Homo sapiens_hsa004100.23041527
138Prion diseases_Homo sapiens_hsa050200.20517945
139Wnt signaling pathway_Homo sapiens_hsa043100.19342928
140Taste transduction_Homo sapiens_hsa047420.19141528
141Renin secretion_Homo sapiens_hsa049240.18957765
142Alcoholism_Homo sapiens_hsa050340.18288197
143Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.18182266
144Glycerolipid metabolism_Homo sapiens_hsa005610.17060827

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