MOCS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Molybdenum cofactor biosynthesis is a conserved pathway leading to the biological activation of molybdenum. The protein encoded by this gene is involved in this pathway. This gene was originally thought to produce a bicistronic mRNA with the potential to produce two proteins (MOCS1A and MOCS1B) from adjacent open reading frames. However, only the first open reading frame (MOCS1A) has been found to encode a protein from the putative bicistronic mRNA, whereas additional splice variants, whose full-length natures have yet to be determined, are likely to produce a fusion between the two open reading frames. This gene is defective in patients with molybdenum cofactor deficiency, type A. A related pseudogene has been identified on chromosome 16. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.84742850
2L-phenylalanine catabolic process (GO:0006559)6.84742850
3L-phenylalanine metabolic process (GO:0006558)6.60667782
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.60667782
5aromatic amino acid family catabolic process (GO:0009074)6.22203117
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.05572350
7tryptophan catabolic process (GO:0006569)5.69261317
8indole-containing compound catabolic process (GO:0042436)5.69261317
9indolalkylamine catabolic process (GO:0046218)5.69261317
10alpha-linolenic acid metabolic process (GO:0036109)5.63155246
11kynurenine metabolic process (GO:0070189)5.57882749
12bile acid biosynthetic process (GO:0006699)5.44601005
13urea metabolic process (GO:0019627)5.39973374
14urea cycle (GO:0000050)5.39973374
15tryptophan metabolic process (GO:0006568)5.39877347
16glyoxylate metabolic process (GO:0046487)5.29754355
17complement activation, alternative pathway (GO:0006957)5.25605963
18high-density lipoprotein particle remodeling (GO:0034375)5.21475535
19protein carboxylation (GO:0018214)5.19508508
20peptidyl-glutamic acid carboxylation (GO:0017187)5.19508508
21sulfur amino acid catabolic process (GO:0000098)5.17839101
22cysteine metabolic process (GO:0006534)5.15250257
23negative regulation of fibrinolysis (GO:0051918)5.13488741
24fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.04643078
25regulation of protein activation cascade (GO:2000257)5.02057859
26nitrogen cycle metabolic process (GO:0071941)4.95212420
27regulation of fibrinolysis (GO:0051917)4.85304698
28regulation of triglyceride catabolic process (GO:0010896)4.83673094
29regulation of complement activation (GO:0030449)4.72807143
30serine family amino acid catabolic process (GO:0009071)4.70985024
31bile acid metabolic process (GO:0008206)4.65882319
32reverse cholesterol transport (GO:0043691)4.61157417
33regulation of cholesterol esterification (GO:0010872)4.58401528
34lysine metabolic process (GO:0006553)4.58201494
35lysine catabolic process (GO:0006554)4.58201494
36homocysteine metabolic process (GO:0050667)4.52601222
37phospholipid efflux (GO:0033700)4.50157707
38protein-lipid complex remodeling (GO:0034368)4.49740337
39macromolecular complex remodeling (GO:0034367)4.49740337
40plasma lipoprotein particle remodeling (GO:0034369)4.49740337
41aromatic amino acid family metabolic process (GO:0009072)4.49691888
42amino-acid betaine metabolic process (GO:0006577)4.44357434
43plasma lipoprotein particle clearance (GO:0034381)4.43044518
44triglyceride homeostasis (GO:0070328)4.38953088
45acylglycerol homeostasis (GO:0055090)4.38953088
46tyrosine metabolic process (GO:0006570)4.37977096
47negative regulation of sterol transport (GO:0032372)4.36974870
48negative regulation of cholesterol transport (GO:0032375)4.36974870
49alpha-amino acid catabolic process (GO:1901606)4.27649007
50ethanol oxidation (GO:0006069)4.07665242
51cholesterol efflux (GO:0033344)4.04660776
52plasma lipoprotein particle assembly (GO:0034377)4.03105087
53indolalkylamine metabolic process (GO:0006586)4.02417772
54bile acid and bile salt transport (GO:0015721)4.02160833
55glycine metabolic process (GO:0006544)4.00410692
56imidazole-containing compound metabolic process (GO:0052803)3.97723132
57coenzyme catabolic process (GO:0009109)3.97368789
58cellular glucuronidation (GO:0052695)3.95692553
59cellular amino acid catabolic process (GO:0009063)3.94746505
60cellular ketone body metabolic process (GO:0046950)3.91785122
61amine catabolic process (GO:0009310)3.89067357
62cellular biogenic amine catabolic process (GO:0042402)3.89067357
63NADH metabolic process (GO:0006734)3.87855393
64serine family amino acid metabolic process (GO:0009069)3.85970326
65phospholipid homeostasis (GO:0055091)3.85236828
66positive regulation of lipid catabolic process (GO:0050996)3.82714436
67positive regulation of lipoprotein lipase activity (GO:0051006)3.82202425
68positive regulation of triglyceride lipase activity (GO:0061365)3.82202425
69glutamate metabolic process (GO:0006536)3.82085183
70benzene-containing compound metabolic process (GO:0042537)3.81540218
71cellular modified amino acid catabolic process (GO:0042219)3.79935180
72arginine metabolic process (GO:0006525)3.74888916
73very-low-density lipoprotein particle assembly (GO:0034379)3.73529584
74regulation of cholesterol homeostasis (GO:2000188)3.73024807
75drug catabolic process (GO:0042737)3.70979616
76fibrinolysis (GO:0042730)3.68758768
77protein-lipid complex assembly (GO:0065005)3.65141169
78dicarboxylic acid biosynthetic process (GO:0043650)3.65102005
79low-density lipoprotein particle remodeling (GO:0034374)3.64781369
80cholesterol homeostasis (GO:0042632)3.63430133
81serine family amino acid biosynthetic process (GO:0009070)3.62191284
82complement activation (GO:0006956)3.60746101
83acetyl-CoA metabolic process (GO:0006084)3.60453874
84plasma lipoprotein particle organization (GO:0071827)3.59366513
85complement activation, classical pathway (GO:0006958)3.59274559
86sterol homeostasis (GO:0055092)3.58280224
87negative regulation of lipase activity (GO:0060192)3.57615206
88aldehyde catabolic process (GO:0046185)3.56590258
89positive regulation of fatty acid beta-oxidation (GO:0032000)3.56581575
90protein activation cascade (GO:0072376)3.55148048
91carboxylic acid catabolic process (GO:0046395)3.52784773
92organic acid catabolic process (GO:0016054)3.52784773
93regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.51258232
94cofactor catabolic process (GO:0051187)3.50639974
95short-chain fatty acid metabolic process (GO:0046459)3.50304435
96uronic acid metabolic process (GO:0006063)3.49965979
97glucuronate metabolic process (GO:0019585)3.49965979
98cell migration involved in heart development (GO:0060973)3.49456512
99triglyceride catabolic process (GO:0019433)3.48798747
100blood coagulation, intrinsic pathway (GO:0007597)3.46550749
101acute-phase response (GO:0006953)3.44351779
102nicotinamide nucleotide biosynthetic process (GO:0019359)3.43285239
103pyridine nucleotide biosynthetic process (GO:0019363)3.43285239
104fatty acid oxidation (GO:0019395)3.42148966
105regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.25832944
106acylglycerol catabolic process (GO:0046464)3.24594052
107neutral lipid catabolic process (GO:0046461)3.24594052
108kidney mesenchyme development (GO:0072074)3.19980676
109cardiac myofibril assembly (GO:0055003)3.18145891
110regulation of sequestering of triglyceride (GO:0010889)3.10702525
111metanephric mesenchyme development (GO:0072075)3.07774746
112basement membrane organization (GO:0071711)3.06454747
113low-density lipoprotein particle clearance (GO:0034383)3.05449999
114fatty acid homeostasis (GO:0055089)3.01961007
115oxaloacetate metabolic process (GO:0006107)2.94783470
116actin-myosin filament sliding (GO:0033275)2.88148487
117muscle filament sliding (GO:0030049)2.88148487
118cGMP-mediated signaling (GO:0019934)2.78940695
119heart trabecula formation (GO:0060347)2.77942229
120retina vasculature morphogenesis in camera-type eye (GO:0061299)2.75329096
121myofibril assembly (GO:0030239)2.72181444
122creatine metabolic process (GO:0006600)2.62031970
123gluconeogenesis (GO:0006094)2.58422276
124actin-mediated cell contraction (GO:0070252)2.57463437
125protein heterotrimerization (GO:0070208)2.56599776
126vascular endothelial growth factor signaling pathway (GO:0038084)2.56515689
127paraxial mesoderm development (GO:0048339)2.55749942
128extracellular fibril organization (GO:0043206)2.46744970
1294-hydroxyproline metabolic process (GO:0019471)2.44294023
130barbed-end actin filament capping (GO:0051016)2.43923537
131cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.41680682
132muscle cell migration (GO:0014812)2.40651028
133atrioventricular valve morphogenesis (GO:0003181)2.35845067
134biotin metabolic process (GO:0006768)2.35098592
135hexose biosynthetic process (GO:0019319)2.33790931
136tricarboxylic acid cycle (GO:0006099)2.31823425
137adherens junction assembly (GO:0034333)2.29652248
138cell-substrate adherens junction assembly (GO:0007045)2.28668284
139focal adhesion assembly (GO:0048041)2.28668284
140ethanol metabolic process (GO:0006067)2.28635122
141peripheral nervous system axon ensheathment (GO:0032292)2.28033955
142myelination in peripheral nervous system (GO:0022011)2.28033955
143sarcomere organization (GO:0045214)2.27601431
144cochlea morphogenesis (GO:0090103)2.27019204
145tricarboxylic acid metabolic process (GO:0072350)2.26411654
146endothelial cell morphogenesis (GO:0001886)2.26054530
147positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.24453704
148negative regulation of cartilage development (GO:0061037)2.22798907
149glycerolipid catabolic process (GO:0046503)2.21318529
150aorta morphogenesis (GO:0035909)2.21066309
151diacylglycerol metabolic process (GO:0046339)2.20994286
152glomerular filtration (GO:0003094)2.19719675
153lymph vessel development (GO:0001945)2.19022683
154Notch signaling involved in heart development (GO:0061314)2.19013643
155endocardial cushion morphogenesis (GO:0003203)2.18538605
156regulation of plasminogen activation (GO:0010755)2.17871597
157cell proliferation involved in metanephros development (GO:0072203)2.16505646
158outer ear morphogenesis (GO:0042473)2.15040584
159regulation of cholesterol biosynthetic process (GO:0045540)2.14227489
160carnitine shuttle (GO:0006853)2.12707238
161response to mercury ion (GO:0046689)2.12445890
162trabecula formation (GO:0060343)2.11162796
163proline biosynthetic process (GO:0006561)2.10450070
164renal filtration (GO:0097205)2.10128558
165response to muscle activity (GO:0014850)2.07698204
166tooth mineralization (GO:0034505)2.07491973
167fatty acid catabolic process (GO:0009062)2.07348876
168cardiac muscle contraction (GO:0060048)2.07144052
169negative regulation of chondrocyte differentiation (GO:0032331)2.06676759
170monosaccharide biosynthetic process (GO:0046364)2.06224045
171notochord development (GO:0030903)2.06172137
172fatty acid beta-oxidation (GO:0006635)2.04908843
173protein retention in ER lumen (GO:0006621)2.04752583
1742-oxoglutarate metabolic process (GO:0006103)2.04578602
175negative regulation of catenin import into nucleus (GO:0035414)2.04459735
176cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.04078538
177glomerular basement membrane development (GO:0032836)2.03768435
178cell communication by electrical coupling (GO:0010644)2.03432686
179proline metabolic process (GO:0006560)2.02472054
180lipid particle organization (GO:0034389)2.00944070
181fatty acid transmembrane transport (GO:1902001)1.99765716

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.72319184
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.75829697
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.30683209
4* LXR_22158963_ChIP-Seq_LIVER_Mouse5.99235199
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.48278269
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.78650000
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.65707695
8TRIM28_21343339_ChIP-Seq_HEK293_Human4.20745194
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.78604330
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.59920361
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.38171754
12* ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.8096244
13TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.98708421
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.93645000
15RNF2_18974828_ChIP-Seq_MESCs_Mouse1.89914104
16EZH2_18974828_ChIP-Seq_MESCs_Mouse1.89914104
17HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.89742903
18GATA1_22025678_ChIP-Seq_K562_Human1.88001669
19IRF8_22096565_ChIP-ChIP_GC-B_Human1.87950180
20WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.87761823
21CLOCK_20551151_ChIP-Seq_293T_Human1.86741217
22MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.81671437
23* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.79307803
24SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.79182484
25EED_16625203_ChIP-ChIP_MESCs_Mouse1.75372111
26STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.72448661
27ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.68667646
28STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.67168384
29TBX20_22080862_ChIP-Seq_HEART_Mouse1.67014834
30TBX20_22328084_ChIP-Seq_HEART_Mouse1.67014834
31SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.66768963
32EP300_21415370_ChIP-Seq_HL-1_Mouse1.65975206
33IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.64820062
34THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.64318604
35ZFP281_18757296_ChIP-ChIP_E14_Mouse1.57838647
36TP53_20018659_ChIP-ChIP_R1E_Mouse1.54886858
37FOXA2_19822575_ChIP-Seq_HepG2_Human1.53727466
38SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.51879132
39MTF2_20144788_ChIP-Seq_MESCs_Mouse1.51478437
40ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.48465264
41SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.48302771
42SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.42932453
43NFIB_24661679_ChIP-Seq_LUNG_Mouse1.42764534
44PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.42763806
45POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.40543400
46RARG_19884340_ChIP-ChIP_MEFs_Mouse1.39028450
47EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.38899919
48JARID2_20075857_ChIP-Seq_MESCs_Mouse1.37835882
49CTCF_27219007_Chip-Seq_Bcells_Human1.34725472
50EZH2_27304074_Chip-Seq_ESCs_Mouse1.34578845
51* HNF4A_19822575_ChIP-Seq_HepG2_Human1.30873949
52ERG_21242973_ChIP-ChIP_JURKAT_Human1.30125420
53SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.29666219
54HIF1A_21447827_ChIP-Seq_MCF-7_Human1.28197445
55NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.25392376
56SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.25319750
57Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.25186208
58UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.24505542
59KDM2B_26808549_Chip-Seq_K562_Human1.23846007
60SMC3_22415368_ChIP-Seq_MEFs_Mouse1.23239796
61TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.21746533
62EZH2_27294783_Chip-Seq_ESCs_Mouse1.19119042
63RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.18037550
64SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.17232521
65TET1_21451524_ChIP-Seq_MESCs_Mouse1.15039267
66* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.11189820
67* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.11161010
68RXRA_24833708_ChIP-Seq_LIVER_Mouse1.10835103
69ISL1_27105846_Chip-Seq_CPCs_Mouse1.08603821
70EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.08413527
71SOX9_24532713_ChIP-Seq_HFSC_Mouse1.06348709
72SA1_22415368_ChIP-Seq_MEFs_Mouse1.04892807
73RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.04424778
74SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01963394
75JARID2_20064375_ChIP-Seq_MESCs_Mouse1.01656654
76EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.01589075
77TET1_21490601_ChIP-Seq_MESCs_Mouse1.01324373
78ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00959539
79RNF2_27304074_Chip-Seq_ESCs_Mouse1.00268716
80NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.00259126
81GATA4_25053715_ChIP-Seq_YYC3_Human0.99874029
82ESR1_15608294_ChIP-ChIP_MCF-7_Human0.99659858
83SMC1_22415368_ChIP-Seq_MEFs_Mouse0.99446511
84SUZ12_27294783_Chip-Seq_ESCs_Mouse0.99269083
85HTT_18923047_ChIP-ChIP_STHdh_Human0.99154320
86ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.98753329
87OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.97989809
88STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.97779226
89PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.97496960
90* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.97485241
91KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.97420432
92MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.96454889
93* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.96195299
94* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.95834929
95DNAJC2_21179169_ChIP-ChIP_NT2_Human0.95476125
96P300_27058665_Chip-Seq_ZR-75-30cells_Human0.95358674
97PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.95212986
98ESR2_21235772_ChIP-Seq_MCF-7_Human0.94868848
99* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.94649825
100AR_21909140_ChIP-Seq_LNCAP_Human0.93615428
101RING1B_27294783_Chip-Seq_NPCs_Mouse0.93579151
102EZH2_22144423_ChIP-Seq_EOC_Human0.91854729
103TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.91226566
104TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90762682
105TP53_23651856_ChIP-Seq_MEFs_Mouse0.90349409
106PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.90198224
107WT1_25993318_ChIP-Seq_PODOCYTE_Human0.89925235
108* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.89518989
109LXR_22292898_ChIP-Seq_THP-1_Human0.88274579
110NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.87516423
111IRF8_27001747_Chip-Seq_BMDM_Mouse0.86917132
112ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.84981663
113GATA1_19941827_ChIP-Seq_MEL_Mouse0.84707322
114ESR1_21235772_ChIP-Seq_MCF-7_Human0.81835882
115GATA1_19941826_ChIP-Seq_K562_Human0.81392459
116STAT3_1855785_ChIP-Seq_MESCs_Mouse0.79109215
117SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.78804973
118IRF8_21731497_ChIP-ChIP_J774_Mouse0.75268893
119MYB_21317192_ChIP-Seq_ERMYB_Mouse0.75062618
120SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.73163711
121RARA_24833708_ChIP-Seq_LIVER_Mouse0.72579120
122* GATA2_19941826_ChIP-Seq_K562_Human0.72285857
123GATA6_25053715_ChIP-Seq_YYC3_Human0.72231446
124TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.71584519
125BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.71525233
126TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.69625078
127FOXO3_23340844_ChIP-Seq_DLD1_Human0.69220074
128SALL4_18804426_ChIP-ChIP_XEN_Mouse0.69148541
129CDX2_20551321_ChIP-Seq_CACO-2_Human0.66999128
130RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.66003233
131FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.65999778
132PPAR_26484153_Chip-Seq_NCI-H1993_Human0.65359429
133AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.65243777
134NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.64952358
135ZNF263_19887448_ChIP-Seq_K562_Human0.64877632
136SCL_19346495_ChIP-Seq_HPC-7_Human0.63857741
137CEBPB_22108803_ChIP-Seq_LS180_Human0.61892451
138RACK7_27058665_Chip-Seq_MCF-7_Human0.61270454
139RARB_24833708_ChIP-Seq_LIVER_Mouse0.61261929
140CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.60053167
141AUTS2_25519132_ChIP-Seq_293T-REX_Human0.59805890
142* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.59644338
143TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.59624263
144PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.59602603
145BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.59036150
146EGR1_19032775_ChIP-ChIP_M12_Human0.58712031
147BP1_19119308_ChIP-ChIP_Hs578T_Human0.58080452
148GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.55727056
149RAD21_21589869_ChIP-Seq_MESCs_Mouse0.55341875
150ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.54929545
151NRF2_20460467_ChIP-Seq_MEFs_Mouse0.54435571
152NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.54435571
153IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.54242004
154* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.54153457
155PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.53872557
156FOXA1_25552417_ChIP-Seq_VCAP_Human0.53474995
157E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.53148625
158KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.52169256
159FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.52049476
160GATA2_21666600_ChIP-Seq_HMVEC_Human0.52017611
161ELK3_25401928_ChIP-Seq_HUVEC_Human0.50365313
162* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.49541011
163ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.49168858
164PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.49134568
165BCOR_27268052_Chip-Seq_Bcells_Human0.49069280
166KAP1_22055183_ChIP-Seq_ESCs_Mouse0.49014620
167FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.48778345
168SOX2_20726797_ChIP-Seq_SW620_Human0.48221965
169TP63_17297297_ChIP-ChIP_HaCaT_Human0.47315578

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.63509303
2MP0005360_urolithiasis7.11914085
3MP0005085_abnormal_gallbladder_physiolo5.79635201
4MP0005365_abnormal_bile_salt5.68918418
5MP0008875_abnormal_xenobiotic_pharmacok4.60609681
6MP0003806_abnormal_nucleotide_metabolis3.82773432
7MP0000751_myopathy3.76083307
8MP0003252_abnormal_bile_duct3.60555199
9MP0010329_abnormal_lipoprotein_level3.49269939
10MP0009840_abnormal_foam_cell3.46038599
11MP0004272_abnormal_basement_membrane3.39393447
12MP0005083_abnormal_biliary_tract3.13948128
13MP0003191_abnormal_cellular_cholesterol2.60415838
14MP0001666_abnormal_nutrient_absorption2.56138792
15MP0000749_muscle_degeneration2.54551916
16* MP0005332_abnormal_amino_acid2.47965490
17MP0003195_calcinosis2.41300106
18MP0010030_abnormal_orbit_morphology2.31847814
19MP0000609_abnormal_liver_physiology2.21499512
20MP0003279_aneurysm2.18789145
21MP0005503_abnormal_tendon_morphology2.09571169
22MP0002118_abnormal_lipid_homeostasis2.07851738
23MP0004019_abnormal_vitamin_homeostasis2.01342435
24MP0005275_abnormal_skin_tensile2.00014109
25MP0006138_congestive_heart_failure1.97909949
26MP0002138_abnormal_hepatobiliary_system1.88190099
27MP0005319_abnormal_enzyme/_coenzyme1.86567468
28MP0005375_adipose_tissue_phenotype1.81597757
29MP0004087_abnormal_muscle_fiber1.75272366
30MP0004036_abnormal_muscle_relaxation1.73808041
31MP0005330_cardiomyopathy1.69010605
32MP0003705_abnormal_hypodermis_morpholog1.67707186
33MP0009780_abnormal_chondrocyte_physiolo1.66685271
34MP0003656_abnormal_erythrocyte_physiolo1.66343397
35MP0001299_abnormal_eye_distance/1.65727079
36MP0004084_abnormal_cardiac_muscle1.65462378
37MP0003868_abnormal_feces_composition1.56601079
38MP0000759_abnormal_skeletal_muscle1.54710772
39MP0001764_abnormal_homeostasis1.52319564
40MP0005257_abnormal_intraocular_pressure1.51729206
41MP0002108_abnormal_muscle_morphology1.50084885
42MP0000747_muscle_weakness1.49103418
43MP0004233_abnormal_muscle_weight1.47340350
44MP0005620_abnormal_muscle_contractility1.46954340
45* MP0005584_abnormal_enzyme/coenzyme_acti1.46184379
46MP0003566_abnormal_cell_adhesion1.43963873
47MP0000003_abnormal_adipose_tissue1.43204529
48MP0009384_cardiac_valve_regurgitation1.39462576
49MP0003186_abnormal_redox_activity1.39315479
50MP0001879_abnormal_lymphatic_vessel1.35687392
51MP0003950_abnormal_plasma_membrane1.35386247
52MP0002972_abnormal_cardiac_muscle1.35093229
53MP0005670_abnormal_white_adipose1.35005481
54MP0005623_abnormal_meninges_morphology1.34270528
55MP0000013_abnormal_adipose_tissue1.33981524
56MP0002269_muscular_atrophy1.33415762
57MP0009697_abnormal_copulation1.32058693
58MP0004215_abnormal_myocardial_fiber1.31831242
59MP0004145_abnormal_muscle_electrophysio1.30167865
60MP0001958_emphysema1.29538686
61* MP0009643_abnormal_urine_homeostasis1.28521890
62MP0000534_abnormal_ureter_morphology1.28142453
63MP0005451_abnormal_body_composition1.26921751
64MP0009764_decreased_sensitivity_to1.26725556
65MP0010630_abnormal_cardiac_muscle1.25187367
66MP0005595_abnormal_vascular_smooth1.24713922
67MP0000598_abnormal_liver_morphology1.22323873
68MP0000767_abnormal_smooth_muscle1.20270266
69MP0000762_abnormal_tongue_morphology1.19672626
70MP0002106_abnormal_muscle_physiology1.19250599
71MP0003941_abnormal_skin_development1.19064982
72MP0005369_muscle_phenotype1.18647243
73MP0002254_reproductive_system_inflammat1.18516901
74MP0002249_abnormal_larynx_morphology1.17201284
75MP0000750_abnormal_muscle_regeneration1.16159845
76MP0002295_abnormal_pulmonary_circulatio1.13636146
77MP0003646_muscle_fatigue1.13060701
78MP0009763_increased_sensitivity_to1.12230020
79MP0003011_delayed_dark_adaptation1.11638132
80MP0008469_abnormal_protein_level1.08775627
81MP0000604_amyloidosis1.07653562
82MP0005171_absent_coat_pigmentation1.07433854
83MP0001544_abnormal_cardiovascular_syste1.06731930
84MP0005385_cardiovascular_system_phenoty1.06731930
85MP0005647_abnormal_sex_gland1.06694227
86MP0005508_abnormal_skeleton_morphology1.06478327
87MP0003942_abnormal_urinary_system1.05941533
88MP0003436_decreased_susceptibility_to1.00414167
89MP0004130_abnormal_muscle_cell0.98750951
90MP0004858_abnormal_nervous_system0.98634854
91MP0008775_abnormal_heart_ventricle0.96798063
92MP0003959_abnormal_lean_body0.94063279
93MP0009250_abnormal_appendicular_skeleto0.94039305
94MP0002127_abnormal_cardiovascular_syste0.93697832
95MP0003283_abnormal_digestive_organ0.93408040
96MP0005636_abnormal_mineral_homeostasis0.92398130
97MP0002971_abnormal_brown_adipose0.91209811
98MP0005464_abnormal_platelet_physiology0.90086528
99MP0003724_increased_susceptibility_to0.89987648
100MP0003385_abnormal_body_wall0.89398010
101MP0005187_abnormal_penis_morphology0.89124355
102MP0000462_abnormal_digestive_system0.87758370
103MP0009642_abnormal_blood_homeostasis0.87342353
104MP0000733_abnormal_muscle_development0.86796918
105MP0010368_abnormal_lymphatic_system0.86109604
106MP0005334_abnormal_fat_pad0.84099206
107MP0005165_increased_susceptibility_to0.81092720
108MP0002128_abnormal_blood_circulation0.81011132
109MP0003137_abnormal_impulse_conducting0.79394968
110MP0003091_abnormal_cell_migration0.79047227
111MP0005666_abnormal_adipose_tissue0.76757929
112MP0009765_abnormal_xenobiotic_induced0.76384183
113MP0005376_homeostasis/metabolism_phenot0.74460917
114MP0005058_abnormal_lysosome_morphology0.74105962
115MP0002078_abnormal_glucose_homeostasis0.73747896
116MP0000343_altered_response_to0.73294605
117MP0003300_gastrointestinal_ulcer0.73054484
118MP0006036_abnormal_mitochondrial_physio0.72111979
119MP0005408_hypopigmentation0.69829866
120MP0003136_yellow_coat_color0.69590264
121MP0004085_abnormal_heartbeat0.68641389
122MP0001614_abnormal_blood_vessel0.67720491
123MP0002896_abnormal_bone_mineralization0.67154747
124MP0000049_abnormal_middle_ear0.66385889
125MP0001881_abnormal_mammary_gland0.65840587
126MP0005220_abnormal_exocrine_pancreas0.64367586
127MP0001756_abnormal_urination0.64290784
128MP0004782_abnormal_surfactant_physiolog0.64267428
129MP0002136_abnormal_kidney_physiology0.62935805
130MP0003879_abnormal_hair_cell0.62631655
131MP0003690_abnormal_glial_cell0.62447545
132MP0000266_abnormal_heart_morphology0.62397688
133MP0005452_abnormal_adipose_tissue0.61381948
134MP0005448_abnormal_energy_balance0.60920320
135MP0009672_abnormal_birth_weight0.60858592
136MP0000163_abnormal_cartilage_morphology0.60291008
137MP0006082_CNS_inflammation0.60272655
138MP0001661_extended_life_span0.60161016
139MP0005535_abnormal_body_temperature0.59935518
140MP0004947_skin_inflammation0.59921483
141MP0003075_altered_response_to0.59542447
142MP0002697_abnormal_eye_size0.59377875
143MP0009115_abnormal_fat_cell0.59049122
144MP0001845_abnormal_inflammatory_respons0.56924205
145MP0005266_abnormal_metabolism0.56024840
146MP0002419_abnormal_innate_immunity0.53636042
147MP0001853_heart_inflammation0.53367698
148MP0009053_abnormal_anal_canal0.52255936
149MP0005084_abnormal_gallbladder_morpholo0.52175193
150MP0009785_altered_susceptibility_to0.51989983
151MP0005166_decreased_susceptibility_to0.50359600
152MP0005025_abnormal_response_to0.49798811
153MP0002876_abnormal_thyroid_physiology0.49573308
154MP0000249_abnormal_blood_vessel0.49064503
155MP0008873_increased_physiological_sensi0.48844050
156MP0004185_abnormal_adipocyte_glucose0.48335930
157MP0002928_abnormal_bile_duct0.47956683
158MP0005023_abnormal_wound_healing0.46955667
159MP0002970_abnormal_white_adipose0.46873628
160MP0003453_abnormal_keratinocyte_physiol0.46253319
161MP0003303_peritoneal_inflammation0.46074979
162MP0000639_abnormal_adrenal_gland0.45540438
163MP0002060_abnormal_skin_morphology0.45242477
164MP0001533_abnormal_skeleton_physiology0.44283786
165MP0005395_other_phenotype0.43956088
166MP0000685_abnormal_immune_system0.43700092
167MP0005167_abnormal_blood-brain_barrier0.42553167
168MP0003638_abnormal_response/metabolism_0.42114109
169MP0003329_amyloid_beta_deposits0.42013107
170MP0002168_other_aberrant_phenotype0.41771849
171MP0001243_abnormal_dermal_layer0.40328920
172MP0008438_abnormal_cutaneous_collagen0.40154353
173MP0002796_impaired_skin_barrier0.39318426
174MP0006035_abnormal_mitochondrial_morpho0.38966029
175MP0004147_increased_porphyrin_level0.38636855
176MP0008874_decreased_physiological_sensi0.37800326

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.97855259
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.67478921
3Intrahepatic cholestasis (HP:0001406)6.67131134
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.22443083
5Xanthomatosis (HP:0000991)6.05038792
6Prolonged partial thromboplastin time (HP:0003645)5.98055601
7Hypobetalipoproteinemia (HP:0003563)5.74979732
8Complement deficiency (HP:0004431)5.39482575
9Hyperlipoproteinemia (HP:0010980)5.32239588
10Joint hemorrhage (HP:0005261)4.74963656
11Hypolipoproteinemia (HP:0010981)4.49658593
12Hyperammonemia (HP:0001987)4.45974548
13Type 1 muscle fiber predominance (HP:0003803)4.32898103
14Abnormality of the common coagulation pathway (HP:0010990)4.31179798
15Epidermoid cyst (HP:0200040)4.28324858
16Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.18249191
17Abnormality of glutamine family amino acid metabolism (HP:0010902)4.15923008
18Hypoalphalipoproteinemia (HP:0003233)4.11363616
19Ketosis (HP:0001946)4.09963886
20Premature rupture of membranes (HP:0001788)4.08342640
21Hyperglycinemia (HP:0002154)4.05091815
22Abnormality of complement system (HP:0005339)4.03494911
23Protrusio acetabuli (HP:0003179)3.97866206
24Hyperglycinuria (HP:0003108)3.90295494
25Fat malabsorption (HP:0002630)3.83929210
26* Abnormality of sulfur amino acid metabolism (HP:0004339)3.78001296
27Abnormality of methionine metabolism (HP:0010901)3.78000528
28Abnormality of glycine metabolism (HP:0010895)3.76814674
29Abnormality of serine family amino acid metabolism (HP:0010894)3.76814674
30Abnormality of aspartate family amino acid metabolism (HP:0010899)3.76424468
31Hypoglycemic coma (HP:0001325)3.65305368
32Abnormality of the intrinsic pathway (HP:0010989)3.63151673
33Abnormality of pyrimidine metabolism (HP:0004353)3.62819746
34Hypercholesterolemia (HP:0003124)3.61987129
35Increased variability in muscle fiber diameter (HP:0003557)3.50752598
36Exercise-induced myalgia (HP:0003738)3.50599237
37Conjugated hyperbilirubinemia (HP:0002908)3.44735970
38Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.40946557
39Muscle fiber inclusion bodies (HP:0100299)3.40758543
40Myocardial infarction (HP:0001658)3.37579642
41Abnormality of fatty-acid metabolism (HP:0004359)3.37044461
42Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.36325171
43Nemaline bodies (HP:0003798)3.35155806
44Hyperbilirubinemia (HP:0002904)3.27386265
45Increased connective tissue (HP:0009025)3.23199681
46Systemic lupus erythematosus (HP:0002725)3.23167374
47Spinal rigidity (HP:0003306)3.14929201
48Abnormality of skeletal muscle fiber size (HP:0012084)3.14849673
49Recurrent gram-negative bacterial infections (HP:0005420)3.04190882
50Muscle fiber splitting (HP:0003555)3.01783961
51* Abnormality of nucleobase metabolism (HP:0010932)2.96456521
52Ketoacidosis (HP:0001993)2.93334614
53Steatorrhea (HP:0002570)2.88031045
54Hepatocellular carcinoma (HP:0001402)2.87182023
55Broad metatarsal (HP:0001783)2.86222260
56Abnormality of serum amino acid levels (HP:0003112)2.77840075
57Hypochromic microcytic anemia (HP:0004840)2.77649505
58Hyporeflexia of lower limbs (HP:0002600)2.77277599
59Metabolic acidosis (HP:0001942)2.71377544
60Shallow orbits (HP:0000586)2.70676903
61Distal lower limb muscle weakness (HP:0009053)2.70587326
62Delayed CNS myelination (HP:0002188)2.70513876
63Skin nodule (HP:0200036)2.69528491
64Glomerulonephritis (HP:0000099)2.66867221
65Myoglobinuria (HP:0002913)2.66292234
66Spontaneous abortion (HP:0005268)2.64171572
67Abnormality of the calf musculature (HP:0001430)2.63318087
68* Abnormality of purine metabolism (HP:0004352)2.61694832
69Vascular calcification (HP:0004934)2.60674298
70Acanthocytosis (HP:0001927)2.58109080
71Neck muscle weakness (HP:0000467)2.56202856
72Dicarboxylic aciduria (HP:0003215)2.55159622
73Abnormality of dicarboxylic acid metabolism (HP:0010995)2.55159622
74Aortic aneurysm (HP:0004942)2.54424281
75Spastic diplegia (HP:0001264)2.52173115
76Cholelithiasis (HP:0001081)2.51888368
77Gingival bleeding (HP:0000225)2.50112112
78Abnormal gallbladder morphology (HP:0012437)2.49409587
79Ventricular tachycardia (HP:0004756)2.47907996
80Mildly elevated creatine phosphokinase (HP:0008180)2.45950464
81Amyloidosis (HP:0011034)2.44255883
82Mitral stenosis (HP:0001718)2.44223655
83EMG: myopathic abnormalities (HP:0003458)2.44071424
84Sudden death (HP:0001699)2.43884472
85Esophageal varix (HP:0002040)2.43348431
86Cerebral aneurysm (HP:0004944)2.42672966
87Gout (HP:0001997)2.41448394
88Rhabdomyolysis (HP:0003201)2.40610511
89Lipoatrophy (HP:0100578)2.40070194
90Exercise-induced muscle cramps (HP:0003710)2.36749135
91Cardiovascular calcification (HP:0011915)2.35656326
92Menorrhagia (HP:0000132)2.35088645
93Centrally nucleated skeletal muscle fibers (HP:0003687)2.35004088
94Poikilocytosis (HP:0004447)2.34042524
95Hemorrhage of the eye (HP:0011885)2.30894047
96Lethargy (HP:0001254)2.30809523
97Vascular tortuosity (HP:0004948)2.29589741
98Malnutrition (HP:0004395)2.25575955
99Abnormality of proline metabolism (HP:0010907)2.21483214
100Hydroxyprolinuria (HP:0003080)2.21483214
101Abnormality of iron homeostasis (HP:0011031)2.21308814
102Abnormal gallbladder physiology (HP:0012438)2.21297198
103Cholecystitis (HP:0001082)2.21297198
104Hypoglycemic seizures (HP:0002173)2.21208014
105Back pain (HP:0003418)2.21163432
106Aortic dissection (HP:0002647)2.19157997
107Pancreatitis (HP:0001733)2.18998287
108Round ear (HP:0100830)2.18761764
109Hypoplasia of the iris (HP:0007676)2.18713980
110Abnormality of transition element cation homeostasis (HP:0011030)2.17529636
111Soft skin (HP:0000977)2.16951163
112Acanthosis nigricans (HP:0000956)2.15287844
113Thrombophlebitis (HP:0004418)2.15141083
114Arterial tortuosity (HP:0005116)2.14357934
115Dilated cardiomyopathy (HP:0001644)2.14244159
116Neonatal onset (HP:0003623)2.13662960
117Nephritis (HP:0000123)2.13452899
118Sensorimotor neuropathy (HP:0007141)2.12586971
119Myopathic facies (HP:0002058)2.11044329
120Distal lower limb amyotrophy (HP:0008944)2.08899987
121Irritability (HP:0000737)2.08749919
122Asymmetric septal hypertrophy (HP:0001670)2.08303492
123Turricephaly (HP:0000262)2.06824631
124Late onset (HP:0003584)2.03669354
125Reticulocytosis (HP:0001923)2.03330203
126Abnormality of the gallbladder (HP:0005264)2.01893036
127Generalized aminoaciduria (HP:0002909)2.01226313
128Vomiting (HP:0002013)2.00429236
129Hypertriglyceridemia (HP:0002155)2.00299083
130Pulmonary artery stenosis (HP:0004415)1.99034675
131Ankle contracture (HP:0006466)1.98540063
132Bundle branch block (HP:0011710)1.98249679
133Vertebral compression fractures (HP:0002953)1.94309361
134Brushfield spots (HP:0001088)1.93163531
135Abnormal cartilage morphology (HP:0002763)1.92883080
136Difficulty running (HP:0009046)1.92760220
137Abnormal atrioventricular conduction (HP:0005150)1.91328155
138Cerebral edema (HP:0002181)1.90121783
139Muscle stiffness (HP:0003552)1.89882515
140Abnormal enzyme/coenzyme activity (HP:0012379)1.89514502
141Nausea (HP:0002018)1.89345808
142Increased serum ferritin (HP:0003281)1.88463252
143Oligomenorrhea (HP:0000876)1.87657158
144Atrioventricular block (HP:0001678)1.87594863
145Increased serum pyruvate (HP:0003542)1.84945393
146Limb-girdle muscle atrophy (HP:0003797)1.84886901
147Enlarged kidneys (HP:0000105)1.84292587
148Limb-girdle muscle weakness (HP:0003325)1.83663669
149Ulnar bowing (HP:0003031)1.83247856
150Hypoplastic left heart (HP:0004383)1.82465537
151Elevated hepatic transaminases (HP:0002910)1.81819165
152Infantile muscular hypotonia (HP:0008947)1.81341794
153Polycythemia (HP:0001901)1.80819751
154Scapular winging (HP:0003691)1.80651322
155Gowers sign (HP:0003391)1.80595212
156Rimmed vacuoles (HP:0003805)1.80091500
157Slender build (HP:0001533)1.79714608
158Coronal craniosynostosis (HP:0004440)1.79704003
159Abnormality of glycolysis (HP:0004366)1.76656877
160Lymphangioma (HP:0100764)1.75014544
161Wormian bones (HP:0002645)1.74977879
162Rickets (HP:0002748)1.74904347
163Lower limb amyotrophy (HP:0007210)1.74457645
164Renal cortical cysts (HP:0000803)1.72796651
165Pulmonary embolism (HP:0002204)1.72730689
166Abnormality of dentin (HP:0010299)1.72652938
167Increased mean platelet volume (HP:0011877)1.72632653
168Insulin resistance (HP:0000855)1.72143120
169Muscle hypertrophy of the lower extremities (HP:0008968)1.72136189
170Short nail (HP:0001799)1.71143315
171Heart block (HP:0012722)1.71050886
172Foot dorsiflexor weakness (HP:0009027)1.70512514
173Generalized amyotrophy (HP:0003700)1.70279237
174Abnormality of the foot musculature (HP:0001436)1.69438299
175Bladder diverticulum (HP:0000015)1.68497051
176Calf muscle hypertrophy (HP:0008981)1.68279978
177Hypercalcemia (HP:0003072)1.67021376
178Difficulty climbing stairs (HP:0003551)1.66884308
179Partial duplication of the phalanx of hand (HP:0009999)1.65969490
180Myotonia (HP:0002486)1.65546110
181* Ectopia lentis (HP:0001083)1.65143266
182Bone cyst (HP:0012062)1.64746631

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.38725616
2ERN14.88182028
3SIK14.42941867
4FGFR43.71211157
5MYLK3.30557344
6OBSCN2.98258477
7TRIB32.85906175
8TAOK32.74895132
9PKN22.68079049
10LATS22.50451754
11TYK22.24580056
12TESK12.20507628
13MST1R2.15816324
14EPHB22.03620306
15PHKG22.02854026
16PHKG12.02854026
17DMPK2.00429856
18ERBB41.95734512
19INSRR1.89002204
20PRKD31.84802368
21FLT31.80192151
22CAMK1D1.76366634
23PTK61.74605038
24MAPK111.69064158
25TBK11.63730146
26NTRK11.62939009
27LIMK11.62495057
28NEK91.58230429
29PAK21.55460632
30IRAK31.54796366
31MUSK1.51939198
32DDR21.50072692
33MAP2K31.48631059
34LATS11.45792955
35JAK11.43026023
36MAP3K101.40652657
37MAP3K141.32762481
38EPHB11.30720565
39RIPK11.30216289
40PIK3CG1.29434146
41JAK21.27648792
42PINK11.27148738
43DAPK31.27093539
44ILK1.24175401
45PAK61.22666318
46GRK61.22383723
47PAK41.21548648
48TGFBR21.17085179
49FRK1.15854722
50PRKAA21.14163586
51KDR1.14157297
52MAP3K71.10256041
53MAP2K41.09769214
54ABL21.09312082
55CDK61.07688578
56IKBKE1.07626306
57CAMK1G1.02812217
58ARAF1.02737386
59MAP4K11.02717664
60MAP3K31.01690671
61AKT21.00649229
62DAPK20.99974268
63LMTK20.96328359
64CAMK2G0.95669685
65CSK0.95363221
66MAP3K110.94485190
67EPHA40.94143150
68ROCK10.90170458
69STK380.89434438
70EPHA20.88602141
71GRK50.84761857
72PDK20.84639142
73MOS0.82855532
74FGFR20.82657799
75ZAP700.81295132
76CSF1R0.80936747
77FGFR30.80422431
78SMG10.79539660
79MAPKAPK30.79084136
80PDGFRB0.78083925
81ERBB20.75983295
82KSR20.75795375
83CAMK10.75782153
84ROCK20.75552008
85KIT0.75414901
86MET0.72805941
87JAK30.72325051
88MAPK40.72218390
89MARK10.71909659
90CAMK2D0.69984670
91CDK120.69821868
92BLK0.69531082
93PRKD10.69396830
94EPHA30.69208142
95BMX0.69170847
96MAPK120.66803969
97CAMK2B0.66034611
98SGK30.64357378
99PRKAA10.64103253
100DYRK1B0.63923230
101CDK40.63400009
102PIM20.61539392
103PTK20.60824435
104TTN0.59574065
105PRKG20.59341894
106PAK30.57862896
107TAOK20.57770977
108MTOR0.56823951
109PRKG10.56363028
110GSK3A0.55329022
111STK100.53772062
112EEF2K0.52465511
113PRKCZ0.52014660
114NTRK30.51810152
115IKBKB0.51613918
116PRKACG0.51503131
117CHUK0.50983477
118TYRO30.50492055
119CDK80.50291437
120TIE10.49884412
121BTK0.49785755
122PDPK10.49310522
123PKN10.48684546
124NME10.46925779
125PRKD20.46907457
126LRRK20.46663096
127MAP2K60.46392327
128MAP3K130.45929446
129BUB10.45489735
130VRK20.44528476
131MAP3K50.43073275
132PIM10.42129955
133PDGFRA0.40996184
134STK40.40784183
135MAP3K120.40611514
136EGFR0.40526760
137STK30.40502255
138CAMK2A0.40427465
139RPS6KA20.40382004
140CDK150.40088611
141STK160.39258000
142CDK11A0.39114911
143MAP2K10.38698261
144MARK20.38462682
145IGF1R0.38132454
146PAK10.37906833
147PIK3CA0.37704838
148STK38L0.35870307
149ICK0.35849834
150BRAF0.35805466
151IRAK40.35571119
152TSSK60.35463347
153MAPK150.35050899
154ITK0.34604643
155MAPK70.33624486
156HCK0.30584725
157RET0.30368129
158MAP2K20.30017189
159ABL10.29595170
160PRKCQ0.29368196
161MAP3K60.29333721
162SIK20.27953471

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.35827171
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.33249377
3Nitrogen metabolism_Homo sapiens_hsa009103.30074424
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.13926315
5Arginine biosynthesis_Homo sapiens_hsa002202.96956133
6Complement and coagulation cascades_Homo sapiens_hsa046102.76484513
7Tryptophan metabolism_Homo sapiens_hsa003802.65599766
8Fatty acid degradation_Homo sapiens_hsa000712.59751780
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.56159096
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.54149289
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.42012007
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.37965513
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.30409211
14Caffeine metabolism_Homo sapiens_hsa002322.27195533
15Peroxisome_Homo sapiens_hsa041462.11119674
16Staphylococcus aureus infection_Homo sapiens_hsa051502.05943857
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.04816768
18PPAR signaling pathway_Homo sapiens_hsa033202.04628485
19Propanoate metabolism_Homo sapiens_hsa006401.97787203
20Butanoate metabolism_Homo sapiens_hsa006501.96190673
21Fatty acid metabolism_Homo sapiens_hsa012121.90668029
22Chemical carcinogenesis_Homo sapiens_hsa052041.89241066
23Histidine metabolism_Homo sapiens_hsa003401.86937084
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.86905500
25Steroid hormone biosynthesis_Homo sapiens_hsa001401.79150876
26Drug metabolism - other enzymes_Homo sapiens_hsa009831.76671893
27beta-Alanine metabolism_Homo sapiens_hsa004101.75398637
28Retinol metabolism_Homo sapiens_hsa008301.63720260
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.60224798
30ECM-receptor interaction_Homo sapiens_hsa045121.59344445
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.57376065
32Selenocompound metabolism_Homo sapiens_hsa004501.54033655
33Dilated cardiomyopathy_Homo sapiens_hsa054141.50684074
34Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.50671324
35Phenylalanine metabolism_Homo sapiens_hsa003601.47792308
36Bile secretion_Homo sapiens_hsa049761.45651914
37Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.37618294
38Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.36998396
39Pyruvate metabolism_Homo sapiens_hsa006201.36502130
40Starch and sucrose metabolism_Homo sapiens_hsa005001.36089186
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.33050321
42Tyrosine metabolism_Homo sapiens_hsa003501.32871930
43Sulfur metabolism_Homo sapiens_hsa009201.32492927
44ABC transporters_Homo sapiens_hsa020101.31668073
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.30340913
46Fat digestion and absorption_Homo sapiens_hsa049751.30337931
47Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.29559788
48Cardiac muscle contraction_Homo sapiens_hsa042601.26839213
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.21009559
50Fatty acid elongation_Homo sapiens_hsa000621.16772035
51Biosynthesis of amino acids_Homo sapiens_hsa012301.16391652
52Carbon metabolism_Homo sapiens_hsa012001.16358681
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.10892796
54Focal adhesion_Homo sapiens_hsa045101.00638670
55Steroid biosynthesis_Homo sapiens_hsa001000.99769672
56Lysine degradation_Homo sapiens_hsa003100.96326057
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.94827336
58Vitamin digestion and absorption_Homo sapiens_hsa049770.94742839
59Protein digestion and absorption_Homo sapiens_hsa049740.91810896
60Arginine and proline metabolism_Homo sapiens_hsa003300.90968951
61Cyanoamino acid metabolism_Homo sapiens_hsa004600.89102889
62Fatty acid biosynthesis_Homo sapiens_hsa000610.86141949
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.83677122
64Vitamin B6 metabolism_Homo sapiens_hsa007500.82225172
65Glycerolipid metabolism_Homo sapiens_hsa005610.80834330
66Maturity onset diabetes of the young_Homo sapiens_hsa049500.80623631
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.78483259
68* Folate biosynthesis_Homo sapiens_hsa007900.77887819
69Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.75496006
70Parkinsons disease_Homo sapiens_hsa050120.74858191
71One carbon pool by folate_Homo sapiens_hsa006700.74165558
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73652057
73Glutathione metabolism_Homo sapiens_hsa004800.69831859
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.68667598
75Pentose phosphate pathway_Homo sapiens_hsa000300.68047933
76cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65659836
77Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.64571728
78Alzheimers disease_Homo sapiens_hsa050100.63426032
79Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.63205239
80Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.60528388
81Adherens junction_Homo sapiens_hsa045200.59089844
82Oxidative phosphorylation_Homo sapiens_hsa001900.58552875
83Basal cell carcinoma_Homo sapiens_hsa052170.55738498
84* Sulfur relay system_Homo sapiens_hsa041220.55566469
85Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.55535144
86Renin secretion_Homo sapiens_hsa049240.55177459
87Aldosterone synthesis and secretion_Homo sapiens_hsa049250.54549640
88Tight junction_Homo sapiens_hsa045300.53815711
89Melanogenesis_Homo sapiens_hsa049160.51006496
90Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50390907
91Gap junction_Homo sapiens_hsa045400.47415983
92Galactose metabolism_Homo sapiens_hsa000520.42748897
93Huntingtons disease_Homo sapiens_hsa050160.40944675
94* Metabolic pathways_Homo sapiens_hsa011000.40342532
95Adipocytokine signaling pathway_Homo sapiens_hsa049200.39937625
96Insulin resistance_Homo sapiens_hsa049310.39831811
97Hippo signaling pathway_Homo sapiens_hsa043900.39555894
98Mineral absorption_Homo sapiens_hsa049780.39551573
99Circadian rhythm_Homo sapiens_hsa047100.37328320
100Notch signaling pathway_Homo sapiens_hsa043300.36563491
101Proteoglycans in cancer_Homo sapiens_hsa052050.35688372
102Fructose and mannose metabolism_Homo sapiens_hsa000510.31445522
103Thyroid hormone signaling pathway_Homo sapiens_hsa049190.30026491
104Prion diseases_Homo sapiens_hsa050200.29933663
105alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.22872751
106Linoleic acid metabolism_Homo sapiens_hsa005910.16521969
107Glycerophospholipid metabolism_Homo sapiens_hsa005640.15580009
108AMPK signaling pathway_Homo sapiens_hsa041520.12642954
109Glycosaminoglycan degradation_Homo sapiens_hsa005310.12545700
110Glucagon signaling pathway_Homo sapiens_hsa049220.05972426
111Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.00241065
112Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1172889
113Other glycan degradation_Homo sapiens_hsa00511-0.1110941
114Bladder cancer_Homo sapiens_hsa05219-0.1104149
115African trypanosomiasis_Homo sapiens_hsa05143-0.1048496
116Legionellosis_Homo sapiens_hsa05134-0.0948622
117Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0896242
118Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0869646
119Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.0821613
120Toll-like receptor signaling pathway_Homo sapiens_hsa04620-0.0748201
121Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0710745
122Amoebiasis_Homo sapiens_hsa05146-0.0666471
123Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0606234
124Malaria_Homo sapiens_hsa05144-0.0572250
125Lysosome_Homo sapiens_hsa04142-0.0529539
126RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.0274051
127Insulin signaling pathway_Homo sapiens_hsa04910-0.0234376
128Renin-angiotensin system_Homo sapiens_hsa04614-0.0184498
129Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0161706
130Pertussis_Homo sapiens_hsa05133-0.0100443
131Hepatitis C_Homo sapiens_hsa05160-0.0072760

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »