MOB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.47793154
2ribosomal small subunit assembly (GO:0000028)5.85111781
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.83195303
4negative regulation of cell killing (GO:0031342)4.83195303
5viral transcription (GO:0019083)4.67631102
6maturation of SSU-rRNA (GO:0030490)4.45461255
7translational termination (GO:0006415)4.44350084
8negative regulation of erythrocyte differentiation (GO:0045647)4.32933399
9SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.32330508
10neutrophil activation involved in immune response (GO:0002283)4.27250050
11cotranslational protein targeting to membrane (GO:0006613)4.22673302
12protein targeting to ER (GO:0045047)4.18812516
13antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.10456408
14antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.10456408
15translational elongation (GO:0006414)4.04274484
16protein localization to endoplasmic reticulum (GO:0070972)4.03123061
17ribosomal small subunit biogenesis (GO:0042274)4.02699031
18establishment of protein localization to endoplasmic reticulum (GO:0072599)4.02178333
19positive regulation of gamma-delta T cell activation (GO:0046645)3.99735398
20deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.87599700
21response to peptidoglycan (GO:0032494)3.86117328
22telomere maintenance via semi-conservative replication (GO:0032201)3.73353353
23viral life cycle (GO:0019058)3.57636490
24negative regulation of interleukin-12 production (GO:0032695)3.57524226
25DNA strand elongation involved in DNA replication (GO:0006271)3.57362806
26antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.55929075
27respiratory chain complex IV assembly (GO:0008535)3.50547049
28positive regulation by symbiont of host defense response (GO:0052509)3.49357591
29modulation by symbiont of host defense response (GO:0052031)3.49357591
30modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.49357591
31modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.49357591
32positive regulation by organism of defense response of other organism involved in symbiotic interact3.49357591
33modulation by symbiont of host immune response (GO:0052553)3.49357591
34detection of other organism (GO:0098543)3.46212400
35detection of bacterium (GO:0016045)3.46183280
36DNA strand elongation (GO:0022616)3.43996949
37translational initiation (GO:0006413)3.43002244
38macrophage activation involved in immune response (GO:0002281)3.42820570
39antigen processing and presentation of endogenous antigen (GO:0019883)3.42776718
40peptidyl-histidine modification (GO:0018202)3.42121240
41cellular protein complex disassembly (GO:0043624)3.40440950
42telomere maintenance via recombination (GO:0000722)3.40382562
43antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.40264549
44positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.38836188
45immunoglobulin mediated immune response (GO:0016064)3.35598375
46nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.33561517
47negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.33131593
48DNA replication checkpoint (GO:0000076)3.32756973
49formation of translation preinitiation complex (GO:0001731)3.26543255
50response to muramyl dipeptide (GO:0032495)3.25852751
51oxidative phosphorylation (GO:0006119)3.25584813
52pseudouridine synthesis (GO:0001522)3.25260152
53translation (GO:0006412)3.21771099
54signal peptide processing (GO:0006465)3.21344501
55lipopolysaccharide-mediated signaling pathway (GO:0031663)3.20352841
56regulation of T-helper 2 cell differentiation (GO:0045628)3.17296722
57mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.17115719
58ribosomal large subunit biogenesis (GO:0042273)3.15968674
59regulation of cellular amino acid metabolic process (GO:0006521)3.15431625
60termination of RNA polymerase III transcription (GO:0006386)3.15227905
61transcription elongation from RNA polymerase III promoter (GO:0006385)3.15227905
62granulocyte activation (GO:0036230)3.13441002
63regulation of mast cell degranulation (GO:0043304)3.13126398
64NIK/NF-kappaB signaling (GO:0038061)3.11924192
65germinal center formation (GO:0002467)3.11308999
66DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.09815166
67negative regulation of ligase activity (GO:0051352)3.05401891
68negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.05401891
69intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.04797904
70signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.04797904
71positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.03495047
72GDP-mannose metabolic process (GO:0019673)3.03138092
73cytochrome complex assembly (GO:0017004)3.02685420
74leukocyte aggregation (GO:0070486)3.02435686
75proteasome assembly (GO:0043248)3.02419035
76mitotic recombination (GO:0006312)3.01998816
77signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.01167581
78signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.01167581
79signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.01167581
80L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.99359816
81regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.98479367
82purine nucleobase biosynthetic process (GO:0009113)2.98373617
83type I interferon signaling pathway (GO:0060337)2.98120722
84cellular response to type I interferon (GO:0071357)2.98120722
85nucleobase biosynthetic process (GO:0046112)2.95171808
86heme biosynthetic process (GO:0006783)2.94816282
87anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.94770419
88protein complex disassembly (GO:0043241)2.94516861
89response to type I interferon (GO:0034340)2.94267888
90neutrophil activation (GO:0042119)2.93662196
91metallo-sulfur cluster assembly (GO:0031163)2.91850770
92iron-sulfur cluster assembly (GO:0016226)2.91850770
93positive regulation of B cell differentiation (GO:0045579)2.91078167
94regulation of gamma-delta T cell activation (GO:0046643)2.90695872
95signal transduction involved in DNA damage checkpoint (GO:0072422)2.88911648
96signal transduction involved in DNA integrity checkpoint (GO:0072401)2.88911648
97regulation of leukocyte degranulation (GO:0043300)2.88249602
98macromolecular complex disassembly (GO:0032984)2.84409956
99regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.84268972
100deoxyribose phosphate biosynthetic process (GO:0046385)2.83943522
1012-deoxyribonucleotide biosynthetic process (GO:0009265)2.83943522
102DNA replication initiation (GO:0006270)2.83598170
103myeloid dendritic cell differentiation (GO:0043011)2.83097032
104purine-containing compound salvage (GO:0043101)2.82188189
105signal transduction involved in cell cycle checkpoint (GO:0072395)2.81749621
106mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.80760325
107mitochondrial respiratory chain complex I assembly (GO:0032981)2.80760325
108NADH dehydrogenase complex assembly (GO:0010257)2.80760325
109myeloid cell activation involved in immune response (GO:0002275)2.80354315
110telomere maintenance via telomere lengthening (GO:0010833)2.79259209
111detection of external biotic stimulus (GO:0098581)2.79116745
112antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.79086328
113regulation of myeloid leukocyte mediated immunity (GO:0002886)2.78977922
114negative regulation of innate immune response (GO:0045824)2.77735690
115negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.77112150
116antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.76801353
117cellular response to thyroid hormone stimulus (GO:0097067)2.76596101
118ribonucleoprotein complex biogenesis (GO:0022613)2.75784868
119regulation of mast cell activation involved in immune response (GO:0033006)2.75353315
120ATP synthesis coupled proton transport (GO:0015986)2.75187550
121energy coupled proton transport, down electrochemical gradient (GO:0015985)2.75187550
122protein targeting to membrane (GO:0006612)2.75066668
123regulation of dendritic cell antigen processing and presentation (GO:0002604)2.73916802
124regulation of B cell receptor signaling pathway (GO:0050855)2.73499738
125activation of MAPKKK activity (GO:0000185)2.73436631
126negative regulation of cytokine production involved in immune response (GO:0002719)2.71530654
127regulation of interferon-beta biosynthetic process (GO:0045357)2.70691725
128negative regulation of leukocyte mediated immunity (GO:0002704)2.70271584
129negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.70020090
130defense response to protozoan (GO:0042832)2.69787718
131aerobic respiration (GO:0009060)2.69543586
132nuclear-transcribed mRNA catabolic process (GO:0000956)2.69510166
133exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.67690018
134interferon-gamma-mediated signaling pathway (GO:0060333)2.67617947
135adenosine receptor signaling pathway (GO:0001973)2.67327578
136regulation of necrotic cell death (GO:0010939)2.66734810
137mitochondrial respiratory chain complex assembly (GO:0033108)2.66561401
138protein complex biogenesis (GO:0070271)2.66230414
139negative regulation of lymphocyte mediated immunity (GO:0002707)2.66139274
140regulation of T-helper 1 cell differentiation (GO:0045625)2.65539888
141response to protozoan (GO:0001562)2.64293147
142protein localization to endosome (GO:0036010)2.63744220
143purine nucleotide salvage (GO:0032261)2.63629835
144nucleobase-containing small molecule interconversion (GO:0015949)2.63313281
145positive regulation of type 2 immune response (GO:0002830)2.62801052
146positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.60876370
147Arp2/3 complex-mediated actin nucleation (GO:0034314)2.59835299
148mannose metabolic process (GO:0006013)2.59487852
149positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.58838946
150modulation by symbiont of host cellular process (GO:0044068)2.57236947
151NADH metabolic process (GO:0006734)2.56850278
152positive thymic T cell selection (GO:0045059)2.56617236
153GMP metabolic process (GO:0046037)2.56451987
154guanosine-containing compound biosynthetic process (GO:1901070)2.55951057
155cellular component biogenesis (GO:0044085)2.55501462
156positive regulation of ligase activity (GO:0051351)2.55048752
157rRNA processing (GO:0006364)2.54230337
158myeloid dendritic cell activation (GO:0001773)2.53936220
159regulation of type 2 immune response (GO:0002828)2.53728419
160mRNA catabolic process (GO:0006402)2.53493320
161protein deneddylation (GO:0000338)2.53281242
162positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.53201835
163positive regulation of mast cell activation (GO:0033005)2.52553016
164nucleotide-excision repair, DNA gap filling (GO:0006297)2.52033098
165nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.51498922
166tolerance induction (GO:0002507)2.49954359
167positive regulation of Cdc42 GTPase activity (GO:0043089)2.49938456
168regulation of gamma-delta T cell differentiation (GO:0045586)2.48046998
169regulation of necroptotic process (GO:0060544)2.47084171
170T cell migration (GO:0072678)2.46287670
171barbed-end actin filament capping (GO:0051016)2.46023748
172regulation of T cell tolerance induction (GO:0002664)2.44145102
173lipoxygenase pathway (GO:0019372)2.43921907
174positive regulation of cellular amide metabolic process (GO:0034250)2.43598252
175positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.42977091
176signal complex assembly (GO:0007172)2.41614562
177detection of biotic stimulus (GO:0009595)2.41588412
178positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.41425274
179regulation of regulated secretory pathway (GO:1903305)2.40207781
180regulation of podosome assembly (GO:0071801)2.39533076
181response to host immune response (GO:0052572)2.39097463
182response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.39097463
183negative regulation of T cell mediated immunity (GO:0002710)2.38775331
184respiratory burst (GO:0045730)2.37838469
185leukocyte degranulation (GO:0043299)2.35652959
186cellular extravasation (GO:0045123)2.34487936
187negative regulation of interleukin-6 production (GO:0032715)2.33823894
188regulation of type I interferon-mediated signaling pathway (GO:0060338)2.33255953
189regulation of tumor necrosis factor superfamily cytokine production (GO:1903555)2.33247611
190macrophage activation (GO:0042116)2.33037016
191G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.31946503
192regulation of mast cell activation (GO:0033003)2.30977662
193negative regulation of type 2 immune response (GO:0002829)2.30808175
194positive regulation of tumor necrosis factor production (GO:0032760)2.30631136
195mature B cell differentiation involved in immune response (GO:0002313)2.30276536

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.66222897
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.91170434
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.27107552
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.17813388
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.17803379
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.15837739
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.95238022
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.79175687
9THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.76758297
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.74602690
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.69730494
12SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.66720184
13GATA1_22025678_ChIP-Seq_K562_Human2.61884402
14* LXR_22292898_ChIP-Seq_THP-1_Human2.55003614
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.52409812
16SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.50392892
17KDM2B_26808549_Chip-Seq_SUP-B15_Human2.43558270
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.42663794
19TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.36219752
20ELK3_25401928_ChIP-Seq_HUVEC_Human2.35757601
21FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.35341251
22CREB1_15753290_ChIP-ChIP_HEK293T_Human2.33526291
23VDR_23849224_ChIP-Seq_CD4+_Human2.31848250
24TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.20036467
25KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.11221350
26SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.08777212
27IRF8_22096565_ChIP-ChIP_GC-B_Human2.08123844
28MYC_19030024_ChIP-ChIP_MESCs_Mouse2.07680621
29RARG_19884340_ChIP-ChIP_MEFs_Mouse2.07366980
30SRF_21415370_ChIP-Seq_HL-1_Mouse2.05735740
31TCF7_22412390_ChIP-Seq_EML_Mouse2.03868593
32KDM2B_26808549_Chip-Seq_DND41_Human2.03234341
33HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.97574761
34FOXP3_21729870_ChIP-Seq_TREG_Human1.96018850
35* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.95867381
36CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.94551018
37NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.94298866
38DCP1A_22483619_ChIP-Seq_HELA_Human1.94205837
39IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.91690651
40RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.91656319
41ERG_20887958_ChIP-Seq_HPC-7_Mouse1.90941056
42E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.90263184
43TP63_17297297_ChIP-ChIP_HaCaT_Human1.89978025
44STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.88468855
45SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.87467580
46MYC_19079543_ChIP-ChIP_MESCs_Mouse1.87210861
47PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.87094888
48E2F4_17652178_ChIP-ChIP_JURKAT_Human1.86995382
49* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.86917207
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.84880909
51E2F1_18555785_ChIP-Seq_MESCs_Mouse1.84147301
52SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.83593692
53NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.82763256
54XRN2_22483619_ChIP-Seq_HELA_Human1.82481023
55CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.82276750
56FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.78396701
57CIITA_25753668_ChIP-Seq_RAJI_Human1.78080092
58IRF8_27001747_Chip-Seq_BMDM_Mouse1.77967845
59GABP_19822575_ChIP-Seq_HepG2_Human1.77047332
60MYC_22102868_ChIP-Seq_BL_Human1.76055689
61RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.73872451
62NOTCH1_21737748_ChIP-Seq_TLL_Human1.71261019
63SPI1_23547873_ChIP-Seq_NB4_Human1.69826234
64THAP11_20581084_ChIP-Seq_MESCs_Mouse1.67420152
65SPI1_23127762_ChIP-Seq_K562_Human1.67145297
66SCL_19346495_ChIP-Seq_HPC-7_Human1.67119712
67MAF_26560356_Chip-Seq_TH2_Human1.64988288
68MYB_21317192_ChIP-Seq_ERMYB_Mouse1.64148378
69NELFA_20434984_ChIP-Seq_ESCs_Mouse1.61857074
70GATA1_19941827_ChIP-Seq_MEL_Mouse1.61244311
71SRY_22984422_ChIP-ChIP_TESTIS_Rat1.60461936
72RACK7_27058665_Chip-Seq_MCF-7_Human1.59943215
73VDR_21846776_ChIP-Seq_THP-1_Human1.57146372
74TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.56406526
75YY1_21170310_ChIP-Seq_MESCs_Mouse1.56113689
76BCL6_27268052_Chip-Seq_Bcells_Human1.54623587
77BCOR_27268052_Chip-Seq_Bcells_Human1.51523232
78CTCF_27219007_Chip-Seq_ERYTHROID_Human1.51326059
79STAT4_19710469_ChIP-ChIP_TH1__Mouse1.50192452
80ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.49588731
81ELF1_20517297_ChIP-Seq_JURKAT_Human1.47873111
82P68_20966046_ChIP-Seq_HELA_Human1.47819010
83PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.46697184
84IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.46654879
85TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.45925622
86VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.45435504
87PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44292326
88BP1_19119308_ChIP-ChIP_Hs578T_Human1.43932155
89KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.43702791
90SA1_27219007_Chip-Seq_ERYTHROID_Human1.43664775
91KDM2B_26808549_Chip-Seq_K562_Human1.43104485
92CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.43016485
93TTF2_22483619_ChIP-Seq_HELA_Human1.40720075
94KDM2B_26808549_Chip-Seq_JURKAT_Human1.39172617
95STAT6_21828071_ChIP-Seq_BEAS2B_Human1.37208908
96GATA1_22383799_ChIP-Seq_G1ME_Mouse1.37106936
97PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.36912695
98GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.36687601
99GATA1_19941826_ChIP-Seq_K562_Human1.35522867
100ELK1_19687146_ChIP-ChIP_HELA_Human1.35235226
101LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.34374808
102MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.33294745
103CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.31729592
104RUNX_20019798_ChIP-Seq_JUKART_Human1.31317049
105TET1_21451524_ChIP-Seq_MESCs_Mouse1.30901636
106ZFX_18555785_ChIP-Seq_MESCs_Mouse1.30836332
107CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.28315958
108SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26353048
109SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.25527895
110CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24599379
111GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24418902
112FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.24393787
113ESR2_21235772_ChIP-Seq_MCF-7_Human1.21729006
114NCOR1_26117541_ChIP-Seq_K562_Human1.21392114
115EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.21385059
116SMC4_20622854_ChIP-Seq_HELA_Human1.21161736
117UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.19796366
118DNAJC2_21179169_ChIP-ChIP_NT2_Human1.18551457
119ERG_21242973_ChIP-ChIP_JURKAT_Human1.18274996
120PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18190407
121FOXM1_23109430_ChIP-Seq_U2OS_Human1.18060253
122ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.17822670
123MAF_26560356_Chip-Seq_TH1_Human1.16615486
124SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16326688
125BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.15765321
126NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.14677905
127EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14016797
128LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.13391860
129IRF8_21731497_ChIP-ChIP_J774_Mouse1.13161797
130RUNX1_22412390_ChIP-Seq_EML_Mouse1.12946479
131MYCN_18555785_ChIP-Seq_MESCs_Mouse1.12930529
132CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.12550760
133E2F1_21310950_ChIP-Seq_MCF-7_Human1.11606142
134TFEB_21752829_ChIP-Seq_HELA_Human1.11255858
135MYB_26560356_Chip-Seq_TH2_Human1.09722170
136TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09588035
137CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.09325014
138STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.08429725
139TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08048778
140* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07909635
141GATA2_22383799_ChIP-Seq_G1ME_Mouse1.07514517
142HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.07333704
143Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.06723062
144CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.06502873
145SA1_27219007_Chip-Seq_Bcells_Human1.05796315
146MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.04232995
147EGR1_19374776_ChIP-ChIP_THP-1_Human1.02705974
148ELK1_22589737_ChIP-Seq_MCF10A_Human1.02517015
149YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02052060
150CTCF_21964334_ChIP-Seq_BJAB-B_Human1.01587895
151CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01572462
152MYB_26560356_Chip-Seq_TH1_Human1.01163672
153UTX_26944678_Chip-Seq_JUKART_Human1.01107576
154SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.01029824
155KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.00177755
156FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99711541
157CTCF_26484167_Chip-Seq_Bcells_Mouse0.99690733
158IKZF1_21737484_ChIP-ChIP_HCT116_Human0.99395416
159BRD4_27068464_Chip-Seq_AML-cells_Mouse0.98975320
160POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.98635164
161KDM5A_27292631_Chip-Seq_BREAST_Human0.98068096
162VDR_24763502_ChIP-Seq_THP-1_Human0.97178936
163E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.96698446
164E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.94792261
165GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.93907814
166MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.92934235
167MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.92280632
168PU.1_20513432_ChIP-Seq_Bcells_Mouse0.91230978

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.13193583
2MP0002396_abnormal_hematopoietic_system3.61994232
3MP0005058_abnormal_lysosome_morphology3.26024303
4MP0003693_abnormal_embryo_hatching3.12874653
5MP0004147_increased_porphyrin_level3.11850080
6MP0004510_myositis2.79791310
7MP0005451_abnormal_body_composition2.76650223
8MP0003763_abnormal_thymus_physiology2.63356689
9MP0001835_abnormal_antigen_presentation2.54440129
10MP0003656_abnormal_erythrocyte_physiolo2.50770246
11MP0006054_spinal_hemorrhage2.48814056
12MP0009840_abnormal_foam_cell2.38303829
13MP0006082_CNS_inflammation2.34661987
14MP0009785_altered_susceptibility_to2.32385913
15MP0010094_abnormal_chromosome_stability2.31457824
16MP0005671_abnormal_response_to2.25860344
17MP0003300_gastrointestinal_ulcer2.23299325
18MP0006036_abnormal_mitochondrial_physio2.18841946
19MP0004957_abnormal_blastocyst_morpholog2.17661950
20MP0003724_increased_susceptibility_to2.17026777
21MP0008260_abnormal_autophagy2.15076642
22MP0009278_abnormal_bone_marrow2.06454143
23MP0003172_abnormal_lysosome_physiology2.04784279
24MP0000685_abnormal_immune_system1.99258494
25MP0008007_abnormal_cellular_replicative1.96887614
26MP0005025_abnormal_response_to1.96250053
27MP0000490_abnormal_crypts_of1.96205796
28MP0002398_abnormal_bone_marrow1.91800737
29MP0003077_abnormal_cell_cycle1.88428749
30MP0002166_altered_tumor_susceptibility1.88117615
31MP0005397_hematopoietic_system_phenotyp1.85023126
32MP0001545_abnormal_hematopoietic_system1.85023126
33MP0003436_decreased_susceptibility_to1.83098295
34MP0003075_altered_response_to1.81470135
35MP0009333_abnormal_splenocyte_physiolog1.79572744
36MP0002420_abnormal_adaptive_immunity1.78828144
37MP0000689_abnormal_spleen_morphology1.76391384
38MP0001819_abnormal_immune_cell1.74622224
39MP0008058_abnormal_DNA_repair1.72937599
40MP0008004_abnormal_stomach_pH1.72752124
41MP0003186_abnormal_redox_activity1.71115207
42MP0001800_abnormal_humoral_immune1.68342439
43MP0002723_abnormal_immune_serum1.67905167
44MP0000465_gastrointestinal_hemorrhage1.67484704
45MP0002722_abnormal_immune_system1.66999271
46MP0005075_abnormal_melanosome_morpholog1.65040751
47MP0001873_stomach_inflammation1.64195905
48MP0001853_heart_inflammation1.64192524
49MP0003453_abnormal_keratinocyte_physiol1.62406646
50MP0000716_abnormal_immune_system1.62006011
51MP0005174_abnormal_tail_pigmentation1.61260540
52MP0002429_abnormal_blood_cell1.61172382
53MP0002419_abnormal_innate_immunity1.60668412
54MP0004808_abnormal_hematopoietic_stem1.60483383
55MP0002148_abnormal_hypersensitivity_rea1.58873493
56MP0010155_abnormal_intestine_physiology1.57870519
57MP0009764_decreased_sensitivity_to1.57062074
58MP0005000_abnormal_immune_tolerance1.56895667
59MP0002452_abnormal_antigen_presenting1.56357639
60MP0003111_abnormal_nucleus_morphology1.55518467
61MP0003866_abnormal_defecation1.52874405
62MP0000749_muscle_degeneration1.51025990
63MP0003806_abnormal_nucleotide_metabolis1.50416044
64MP0002998_abnormal_bone_remodeling1.49360685
65MP0003786_premature_aging1.48624796
66MP0005464_abnormal_platelet_physiology1.44796409
67MP0008057_abnormal_DNA_replication1.44200796
68MP0003646_muscle_fatigue1.37603194
69MP0000703_abnormal_thymus_morphology1.36736681
70MP0001845_abnormal_inflammatory_respons1.36019715
71MP0006035_abnormal_mitochondrial_morpho1.35981508
72MP0000604_amyloidosis1.34865086
73MP0008469_abnormal_protein_level1.29885170
74MP0000858_altered_metastatic_potential1.29118320
75MP0002095_abnormal_skin_pigmentation1.27069437
76MP0002019_abnormal_tumor_incidence1.27021185
77MP0002405_respiratory_system_inflammati1.21278444
78MP0005387_immune_system_phenotype1.21110900
79MP0001790_abnormal_immune_system1.21110900
80MP0003828_pulmonary_edema1.20445408
81MP0005166_decreased_susceptibility_to1.19651640
82MP0003705_abnormal_hypodermis_morpholog1.19500728
83MP0002132_abnormal_respiratory_system1.19096572
84MP0005310_abnormal_salivary_gland1.18621382
85MP0002006_tumorigenesis1.18252332
86MP0003329_amyloid_beta_deposits1.16474047
87MP0003879_abnormal_hair_cell1.14058888
88MP0009379_abnormal_foot_pigmentation1.12161337
89MP0000313_abnormal_cell_death1.11760342
90MP0001851_eye_inflammation1.11644858
91MP0005666_abnormal_adipose_tissue1.09698532
92MP0010368_abnormal_lymphatic_system1.08449556
93MP0004130_abnormal_muscle_cell1.07384322
94MP0008874_decreased_physiological_sensi1.07250157
95MP0003690_abnormal_glial_cell1.06286554
96MP0004084_abnormal_cardiac_muscle1.06070098
97MP0001986_abnormal_taste_sensitivity1.05579914
98MP0003448_altered_tumor_morphology1.04689904
99MP0002332_abnormal_exercise_endurance1.04027027
100MP0000343_altered_response_to1.02719779
101MP0005167_abnormal_blood-brain_barrier1.02666629
102MP0001666_abnormal_nutrient_absorption1.00103472
103MP0002837_dystrophic_cardiac_calcinosis0.98805042
104MP0003191_abnormal_cellular_cholesterol0.98627471
105MP0003091_abnormal_cell_migration0.97298349
106MP0000358_abnormal_cell_content/0.96225742
107MP0001533_abnormal_skeleton_physiology0.96104427
108MP0003221_abnormal_cardiomyocyte_apopto0.95898541
109MP0004947_skin_inflammation0.95665621
110MP0003183_abnormal_peptide_metabolism0.94407862
111MP0004185_abnormal_adipocyte_glucose0.94198294
112MP0005390_skeleton_phenotype0.93349385
113MP0005636_abnormal_mineral_homeostasis0.91884192
114MP0005319_abnormal_enzyme/_coenzyme0.91801916
115MP0004381_abnormal_hair_follicle0.91385904
116MP0001849_ear_inflammation0.90630865
117MP0005330_cardiomyopathy0.89832987
118MP0001764_abnormal_homeostasis0.88663455
119MP0000249_abnormal_blood_vessel0.87749055
120MP0003279_aneurysm0.87045270
121MP0000372_irregular_coat_pigmentation0.85563110
122MP0001879_abnormal_lymphatic_vessel0.84906352
123MP0005220_abnormal_exocrine_pancreas0.80361387
124MP0000015_abnormal_ear_pigmentation0.78781342
125MP0003566_abnormal_cell_adhesion0.78121131
126MP0005584_abnormal_enzyme/coenzyme_acti0.77853578
127MP0004215_abnormal_myocardial_fiber0.77706980
128MP0005165_increased_susceptibility_to0.77310935
129MP0004036_abnormal_muscle_relaxation0.76985277
130MP0004858_abnormal_nervous_system0.76180614
131MP0001663_abnormal_digestive_system0.75734913
132MP0005375_adipose_tissue_phenotype0.75382446
133MP0009763_increased_sensitivity_to0.75286641
134MP0000747_muscle_weakness0.75113879
135MP0002933_joint_inflammation0.74776423
136MP0000350_abnormal_cell_proliferation0.74741996
137MP0005023_abnormal_wound_healing0.73646478
138MP0002139_abnormal_hepatobiliary_system0.73392719
139MP0005164_abnormal_response_to0.72618514
140MP0005535_abnormal_body_temperature0.72275497
141MP0010307_abnormal_tumor_latency0.70780661
142MP0005084_abnormal_gallbladder_morpholo0.69887130
143MP0002796_impaired_skin_barrier0.69708057
144MP0001542_abnormal_bone_strength0.68092479
145MP0003795_abnormal_bone_structure0.66750149
146MP0009765_abnormal_xenobiotic_induced0.66707687
147MP0004782_abnormal_surfactant_physiolog0.66387938
148MP0000477_abnormal_intestine_morphology0.65066729
149MP0002138_abnormal_hepatobiliary_system0.64723569
150MP0002877_abnormal_melanocyte_morpholog0.59845552

Predicted human phenotypes

RankGene SetZ-score
1Abnormal number of erythroid precursors (HP:0012131)5.55368512
2Abnormality of cells of the erythroid lineage (HP:0012130)5.52111478
3Eczematoid dermatitis (HP:0000976)4.79711897
4Purpura (HP:0000979)3.78961049
5Abnormality of glycolipid metabolism (HP:0010969)3.69175603
6Abnormality of liposaccharide metabolism (HP:0010968)3.69175603
7Abnormality of glycosphingolipid metabolism (HP:0004343)3.69175603
8IgM deficiency (HP:0002850)3.68321299
9Hepatic necrosis (HP:0002605)3.62930060
10Abnormality of the heme biosynthetic pathway (HP:0010472)3.60051553
11Thrombocytosis (HP:0001894)3.57061438
12Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.56978689
13Decreased activity of mitochondrial respiratory chain (HP:0008972)3.56978689
14Hepatocellular necrosis (HP:0001404)3.53479698
15Elevated erythrocyte sedimentation rate (HP:0003565)3.46674491
16Orchitis (HP:0100796)3.46322841
17Reticulocytopenia (HP:0001896)3.42972984
18Aplastic anemia (HP:0001915)3.42520190
19Chronic otitis media (HP:0000389)3.31044443
20Chronic obstructive pulmonary disease (HP:0006510)3.25514386
21Obstructive lung disease (HP:0006536)3.25514386
22Mitochondrial inheritance (HP:0001427)3.21117361
23Stomatitis (HP:0010280)3.19283097
24Type I transferrin isoform profile (HP:0003642)3.19046356
25Dysostosis multiplex (HP:0000943)3.18652122
26Abnormal mitochondria in muscle tissue (HP:0008316)3.17886726
27Reduced antithrombin III activity (HP:0001976)3.16199133
28Acute necrotizing encephalopathy (HP:0006965)3.15795359
29Increased cerebral lipofuscin (HP:0011813)3.11762374
30Systemic lupus erythematosus (HP:0002725)3.10862353
31Increased CSF lactate (HP:0002490)3.09951120
32Optic neuritis (HP:0100653)3.06862435
33Retrobulbar optic neuritis (HP:0100654)3.06862435
34Increased IgE level (HP:0003212)3.05480665
35Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.02945227
36Abnormal protein N-linked glycosylation (HP:0012347)3.02945227
37Abnormal protein glycosylation (HP:0012346)3.02945227
38Abnormal glycosylation (HP:0012345)3.02945227
39Petechiae (HP:0000967)3.01643153
40Mediastinal lymphadenopathy (HP:0100721)2.93180332
41Recurrent abscess formation (HP:0002722)2.86779787
42Loss of speech (HP:0002371)2.85412360
43Myositis (HP:0100614)2.85152505
44Recurrent gram-negative bacterial infections (HP:0005420)2.81189846
45Increased serum lactate (HP:0002151)2.74425957
46Macrocytic anemia (HP:0001972)2.72411616
47Acute encephalopathy (HP:0006846)2.68561704
48Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.66778276
49Axonal loss (HP:0003447)2.61830709
50Increased neuronal autofluorescent lipopigment (HP:0002074)2.61203806
51Cellulitis (HP:0100658)2.60933961
52Pallor (HP:0000980)2.59805724
53Lactic acidosis (HP:0003128)2.57729060
54Progressive muscle weakness (HP:0003323)2.55222388
55Generalized aminoaciduria (HP:0002909)2.54743597
56Amyloidosis (HP:0011034)2.52145146
57Microcytic anemia (HP:0001935)2.51565784
58Dicarboxylic aciduria (HP:0003215)2.51174994
59Abnormality of dicarboxylic acid metabolism (HP:0010995)2.51174994
60Recurrent fungal infections (HP:0002841)2.50401012
61Recurrent bronchitis (HP:0002837)2.50017931
62Meningitis (HP:0001287)2.45820207
63Gingivitis (HP:0000230)2.45689842
64Exercise intolerance (HP:0003546)2.45432369
65Recurrent bacterial skin infections (HP:0005406)2.44806553
663-Methylglutaconic aciduria (HP:0003535)2.40733391
67Microretrognathia (HP:0000308)2.40250257
68Increased muscle lipid content (HP:0009058)2.38006841
69Keratoconjunctivitis sicca (HP:0001097)2.35182794
70Microvesicular hepatic steatosis (HP:0001414)2.34818157
71Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.33871308
72Hepatosplenomegaly (HP:0001433)2.32769072
73Colon cancer (HP:0003003)2.32111087
74Increased intramyocellular lipid droplets (HP:0012240)2.32072549
75Urticaria (HP:0001025)2.32002406
76Gastrointestinal infarctions (HP:0005244)2.31500033
77Abnormal platelet volume (HP:0011876)2.30697665
78Progressive macrocephaly (HP:0004481)2.30469656
79Abnormality of fatty-acid metabolism (HP:0004359)2.29737288
80Increased IgM level (HP:0003496)2.29489375
81Abnormality of polysaccharide metabolism (HP:0011012)2.29405645
82Abnormality of glycosaminoglycan metabolism (HP:0004371)2.29405645
83Abnormality of mucopolysaccharide metabolism (HP:0011020)2.29405645
84Oral leukoplakia (HP:0002745)2.28783473
85Vasculitis (HP:0002633)2.27470631
86Neuronal loss in central nervous system (HP:0002529)2.26689218
87Menorrhagia (HP:0000132)2.26219854
88Interstitial pulmonary disease (HP:0006530)2.24446695
89Gingival bleeding (HP:0000225)2.23915330
90Pancytopenia (HP:0001876)2.23455093
91Recurrent skin infections (HP:0001581)2.22946740
92Neurofibrillary tangles (HP:0002185)2.21854694
93Pustule (HP:0200039)2.21830323
94Gastrointestinal inflammation (HP:0004386)2.21309189
95Colitis (HP:0002583)2.20244436
96Abnormality of iron homeostasis (HP:0011031)2.19297751
97Encephalitis (HP:0002383)2.18220993
98Respiratory failure (HP:0002878)2.17732888
99Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.17627183
100Inflammation of the large intestine (HP:0002037)2.14864537
101Rhabdomyolysis (HP:0003201)2.14578119
102Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.13798225
103Respiratory difficulties (HP:0002880)2.13708736
104Vacuolated lymphocytes (HP:0001922)2.13557389
105Erythema (HP:0010783)2.12928190
106Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.12495360
107Supranuclear gaze palsy (HP:0000605)2.12226066
108Distal lower limb amyotrophy (HP:0008944)2.11804823
109Increased serum ferritin (HP:0003281)2.11521696
110Neoplasm of head and neck (HP:0012288)2.11449994
111Esophageal neoplasm (HP:0100751)2.11449994
112Urinary glycosaminoglycan excretion (HP:0003541)2.11149478
113Mucopolysacchariduria (HP:0008155)2.11149478
114Episodic fever (HP:0001954)2.10699813
115Hypothermia (HP:0002045)2.10529837
116Cerebral inclusion bodies (HP:0100314)2.09724903
117Lipid accumulation in hepatocytes (HP:0006561)2.08853502
118Poikiloderma (HP:0001029)2.08582057
119Hypergammaglobulinemia (HP:0010702)2.07034423
120Muscle fiber splitting (HP:0003555)2.06216190
121Type 2 muscle fiber atrophy (HP:0003554)2.04855158
122Distal lower limb muscle weakness (HP:0009053)2.04016296
123Keratoconjunctivitis (HP:0001096)2.02653148
124Palpitations (HP:0001962)2.02541866
125Hemorrhage of the eye (HP:0011885)2.02449849
126Hypertensive crisis (HP:0100735)2.01437447
127Increased hepatocellular lipid droplets (HP:0006565)2.01275601
128Asymmetric septal hypertrophy (HP:0001670)2.00768308
129Methylmalonic aciduria (HP:0012120)2.00736302
130Areflexia of lower limbs (HP:0002522)1.99883643
131Pulmonary infiltrates (HP:0002113)1.98952239
132Autoimmune thrombocytopenia (HP:0001973)1.97559713
133Birth length less than 3rd percentile (HP:0003561)1.97282017
134Hypertriglyceridemia (HP:0002155)1.96622572
135Renal Fanconi syndrome (HP:0001994)1.95083579
136Centrally nucleated skeletal muscle fibers (HP:0003687)1.95022410
137Cerebral edema (HP:0002181)1.94466533
138Hypoproteinemia (HP:0003075)1.93544939
139Abnormality of B cell number (HP:0010975)1.93518803
140B lymphocytopenia (HP:0010976)1.93518803
141Impaired platelet aggregation (HP:0003540)1.93232118
142Abnormal platelet function (HP:0011869)1.93232118
143Increased mean platelet volume (HP:0011877)1.92024886
144Increased connective tissue (HP:0009025)1.92023372
145Abnormality of T cell physiology (HP:0011840)1.91967472
146Exertional dyspnea (HP:0002875)1.91675074
147Neutropenia (HP:0001875)1.91047758
148Lymphoma (HP:0002665)1.90763399
149Nuclear cataract (HP:0100018)1.89651211
150Thin bony cortex (HP:0002753)1.88987133
151Chest pain (HP:0100749)1.88648405
152Increased serum pyruvate (HP:0003542)1.88593707
153Abnormality of glycolysis (HP:0004366)1.88593707
154Abnormality of the nasal mucosa (HP:0000433)1.88581380
155Polycythemia (HP:0001901)1.87372755
156IgG deficiency (HP:0004315)1.86990665
157Hemoptysis (HP:0002105)1.86461929
158Muscle fiber atrophy (HP:0100295)1.86141690
159Multiple enchondromatosis (HP:0005701)1.85402908
160Acne (HP:0001061)1.85323537
161Hypoplasia of the thymus (HP:0000778)1.85308155
162Bulbar palsy (HP:0001283)1.85051930
163Polygenic inheritance (HP:0010982)1.84094376
164Vertebral compression fractures (HP:0002953)1.83989324
165Abnormality of skeletal muscle fiber size (HP:0012084)1.83679130
166Rough bone trabeculation (HP:0100670)1.83457337
167Myopathic facies (HP:0002058)1.83350811
168Abnormality of T cells (HP:0002843)1.83131375
169Emphysema (HP:0002097)1.82514812
170Vertigo (HP:0002321)1.82121752
171Progressive neurologic deterioration (HP:0002344)1.81810493
172Lymphopenia (HP:0001888)1.81529542
173T lymphocytopenia (HP:0005403)1.81173578
174Exercise-induced myalgia (HP:0003738)1.80893993
175Abnormality of macrophages (HP:0004311)1.80414390
176Panhypogammaglobulinemia (HP:0003139)1.78995943
177Prolonged bleeding time (HP:0003010)1.78487315
178Ragged-red muscle fibers (HP:0003200)1.77281544
179Recurrent viral infections (HP:0004429)1.76594707
180Spontaneous hematomas (HP:0007420)1.76558686
181Epistaxis (HP:0000421)1.75847921
182Abnormality of cells of the lymphoid lineage (HP:0012140)1.75567802
183Gastrointestinal stroma tumor (HP:0100723)1.73788015
184Granulocytopenia (HP:0001913)1.72436023
185Nonimmune hydrops fetalis (HP:0001790)1.72421139
186Poor head control (HP:0002421)1.69346669

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK163.59046811
2RIPK43.23543650
3PRPF4B3.13506517
4FLT32.93067034
5NME22.92460171
6KIT2.80410884
7EIF2AK32.60396551
8MAP4K12.50849732
9BRSK22.38236075
10TRIB32.35520531
11BCKDK2.31778263
12PIM22.25524686
13KDR2.24923560
14VRK12.13695225
15BUB12.12560221
16WEE12.08885415
17MAP2K32.06556976
18TAOK11.99482637
19TEC1.96719015
20ACVR1B1.87350568
21MAP3K31.76981632
22SIK11.73731086
23RIPK11.73428424
24TIE11.72871767
25MYLK1.72154812
26CSK1.68439184
27EIF2AK11.68041454
28TGFBR11.65825259
29ARAF1.65821898
30MAPKAPK31.60847866
31FES1.59111170
32ZAP701.58130165
33TSSK61.52085809
34TESK11.44860161
35TNK21.44046182
36BTK1.41851075
37MAP3K11.40271451
38CDC71.39561703
39NME11.36720124
40TBK11.35840230
41TYK21.35117300
42TGFBR21.33987071
43MAP3K131.31537692
44FGR1.30982269
45MAP3K111.30341052
46SCYL21.27955542
47RPS6KA41.27388688
48BMX1.27346559
49SMG11.27247036
50SIK21.26376257
51TXK1.24790098
52JAK31.24361559
53MARK21.21984006
54BRSK11.21241558
55DYRK31.20261988
56ERN11.20083874
57CAMKK21.15136114
58IRAK41.14576173
59SRPK11.11606731
60CDK191.08257880
61STK241.08164014
62CDC42BPA1.07611131
63IKBKE1.07447889
64EPHB11.05078077
65TLK11.04660040
66CSF1R1.01341760
67HCK1.01087196
68DYRK1B1.00911212
69PRKD21.00367330
70RPS6KB20.96064391
71MAP3K60.94672766
72CDK80.93327233
73MAP2K60.92340976
74MAP3K120.91366257
75CCNB10.90235600
76DDR20.88928480
77LRRK20.87887604
78IRAK30.87345157
79PIM10.84096453
80MST40.83397594
81SYK0.83242071
82MAPK120.81946059
83KSR20.81204155
84ICK0.81189103
85PDPK10.80449559
86AURKB0.76861917
87EEF2K0.76309036
88IKBKB0.75776710
89STK100.74445942
90OBSCN0.74386034
91STK40.74155019
92CAMKK10.73608363
93SIK30.73411604
94TNIK0.72663169
95ILK0.72214496
96RPS6KL10.71652965
97RPS6KC10.71652965
98PDK10.70425635
99IRAK20.70161884
100JAK20.69619661
101TESK20.69082417
102MOS0.68117972
103NEK10.67652864
104JAK10.67577527
105NLK0.66395648
106ABL20.65180011
107BLK0.64557358
108ATR0.64180030
109MAP3K50.63180056
110RPS6KA20.62833791
111BRAF0.62027342
112MAPK110.62019445
113TAOK30.60784191
114MAPKAPK50.60755251
115TTN0.60351606
116HIPK20.59672851
117CDK70.59591661
118ITK0.59286260
119TAOK20.58925352
120LCK0.57767800
121PAK40.56983108
122MARK30.56295875
123MAPK70.54557309
124NEK20.54550073
125LYN0.53638661
126PLK10.53622313
127RPS6KA60.53555774
128PIK3CG0.53128374
129DAPK30.52869917
130MATK0.52564187
131DAPK10.51871909
132DAPK20.51210531
133BMPR1B0.49501031
134PRKG20.49216692
135MAP3K70.49066175
136ADRBK20.48934317
137EIF2AK20.48397172
138ZAK0.48307592
139GRK60.47700188
140PTK60.47410747
141GRK70.46547485
142TYRO30.46201681
143MAPK40.45016928
144FGFR40.44168702
145BMPR20.43476374
146MAP2K20.42988928
147PASK0.42816679
148STK380.42313092
149FYN0.42150585
150NEK90.40872371
151MAP3K140.40433872
152CSNK2A10.40433333
153MAPKAPK20.39889403
154GRK50.37892832
155CHUK0.36451272
156PTK2B0.35201804
157RAF10.34623695

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.41821868
2DNA replication_Homo sapiens_hsa030304.04628156
3Proteasome_Homo sapiens_hsa030504.01469919
4RNA polymerase_Homo sapiens_hsa030202.95957248
5Mismatch repair_Homo sapiens_hsa034302.94706805
6Protein export_Homo sapiens_hsa030602.63279487
7Base excision repair_Homo sapiens_hsa034102.60511481
8Osteoclast differentiation_Homo sapiens_hsa043802.59186815
9Pyrimidine metabolism_Homo sapiens_hsa002402.53945404
10Homologous recombination_Homo sapiens_hsa034402.35968892
11Toll-like receptor signaling pathway_Homo sapiens_hsa046202.27236056
12Oxidative phosphorylation_Homo sapiens_hsa001902.16104548
13Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.13729671
14Parkinsons disease_Homo sapiens_hsa050122.11257523
15Spliceosome_Homo sapiens_hsa030402.08869807
16Staphylococcus aureus infection_Homo sapiens_hsa051502.02613730
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.02108946
18Nucleotide excision repair_Homo sapiens_hsa034201.96443949
19Malaria_Homo sapiens_hsa051441.93067266
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.91201846
21Tuberculosis_Homo sapiens_hsa051521.82034966
22Non-homologous end-joining_Homo sapiens_hsa034501.80921627
23Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.78834731
24Primary immunodeficiency_Homo sapiens_hsa053401.72346699
25Folate biosynthesis_Homo sapiens_hsa007901.68159889
26Graft-versus-host disease_Homo sapiens_hsa053321.66201128
27TNF signaling pathway_Homo sapiens_hsa046681.62374192
28Autoimmune thyroid disease_Homo sapiens_hsa053201.57159213
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.56154227
30Glycosaminoglycan degradation_Homo sapiens_hsa005311.55612517
31Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.53037320
32Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.51975152
33Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.48923093
34Rheumatoid arthritis_Homo sapiens_hsa053231.46926829
35Salmonella infection_Homo sapiens_hsa051321.46274278
36Antigen processing and presentation_Homo sapiens_hsa046121.45795629
37Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.45050830
38Toxoplasmosis_Homo sapiens_hsa051451.44416748
39Purine metabolism_Homo sapiens_hsa002301.41090465
40Pentose phosphate pathway_Homo sapiens_hsa000301.40995299
41Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.40618156
42VEGF signaling pathway_Homo sapiens_hsa043701.39815353
43Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.38776485
44T cell receptor signaling pathway_Homo sapiens_hsa046601.36861215
45Chemokine signaling pathway_Homo sapiens_hsa040621.35569945
46Huntingtons disease_Homo sapiens_hsa050161.27523346
47Viral myocarditis_Homo sapiens_hsa054161.27204568
48RNA transport_Homo sapiens_hsa030131.25550516
49Platelet activation_Homo sapiens_hsa046111.23344636
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.19087416
51Sulfur relay system_Homo sapiens_hsa041221.18514901
52Cell cycle_Homo sapiens_hsa041101.17156722
53N-Glycan biosynthesis_Homo sapiens_hsa005101.15275958
54Phagosome_Homo sapiens_hsa041451.15264365
55Alzheimers disease_Homo sapiens_hsa050101.14784728
56RNA degradation_Homo sapiens_hsa030181.14537033
57Asthma_Homo sapiens_hsa053101.13979608
58Notch signaling pathway_Homo sapiens_hsa043301.08998755
59Adipocytokine signaling pathway_Homo sapiens_hsa049201.07549865
60Hepatitis C_Homo sapiens_hsa051601.06874652
61Endocytosis_Homo sapiens_hsa041441.04651720
62Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.03892330
63Type I diabetes mellitus_Homo sapiens_hsa049401.02950015
64Prion diseases_Homo sapiens_hsa050201.02611547
65Other glycan degradation_Homo sapiens_hsa005111.02352871
66Bladder cancer_Homo sapiens_hsa052191.01222602
67Cyanoamino acid metabolism_Homo sapiens_hsa004600.99328279
68Leukocyte transendothelial migration_Homo sapiens_hsa046700.98771231
69Hepatitis B_Homo sapiens_hsa051610.98646824
70Chronic myeloid leukemia_Homo sapiens_hsa052200.97115103
71African trypanosomiasis_Homo sapiens_hsa051430.96190928
72Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.95729453
73Non-small cell lung cancer_Homo sapiens_hsa052230.94198824
74Carbon metabolism_Homo sapiens_hsa012000.93754323
75Epstein-Barr virus infection_Homo sapiens_hsa051690.93266125
76Neurotrophin signaling pathway_Homo sapiens_hsa047220.92809735
77Herpes simplex infection_Homo sapiens_hsa051680.92453530
78Basal transcription factors_Homo sapiens_hsa030220.91848741
79Hematopoietic cell lineage_Homo sapiens_hsa046400.91000224
80RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.90931785
81Pancreatic cancer_Homo sapiens_hsa052120.90536256
82AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.87801819
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.85963009
84Fanconi anemia pathway_Homo sapiens_hsa034600.85753502
852-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.85264169
86Phospholipase D signaling pathway_Homo sapiens_hsa040720.85237005
87Amoebiasis_Homo sapiens_hsa051460.83105990
88One carbon pool by folate_Homo sapiens_hsa006700.81702223
89Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.79220662
90Galactose metabolism_Homo sapiens_hsa000520.78795100
91GnRH signaling pathway_Homo sapiens_hsa049120.77761047
92Legionellosis_Homo sapiens_hsa051340.77403715
93p53 signaling pathway_Homo sapiens_hsa041150.74944593
94Sphingolipid signaling pathway_Homo sapiens_hsa040710.74460247
95Vitamin B6 metabolism_Homo sapiens_hsa007500.74227407
96Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.74134616
97Drug metabolism - other enzymes_Homo sapiens_hsa009830.73723657
98Fructose and mannose metabolism_Homo sapiens_hsa000510.70770927
99Systemic lupus erythematosus_Homo sapiens_hsa053220.68869375
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68014579
101Measles_Homo sapiens_hsa051620.67817187
102Collecting duct acid secretion_Homo sapiens_hsa049660.67007886
103Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66875945
104Regulation of autophagy_Homo sapiens_hsa041400.66606403
105Metabolic pathways_Homo sapiens_hsa011000.66408824
106Glutathione metabolism_Homo sapiens_hsa004800.66378200
107Cysteine and methionine metabolism_Homo sapiens_hsa002700.65730219
108Propanoate metabolism_Homo sapiens_hsa006400.63437063
109Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.62298585
110Prolactin signaling pathway_Homo sapiens_hsa049170.62118101
111Pyruvate metabolism_Homo sapiens_hsa006200.61272974
112Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.59842138
113Shigellosis_Homo sapiens_hsa051310.59679348
114Insulin signaling pathway_Homo sapiens_hsa049100.58759074
115Synaptic vesicle cycle_Homo sapiens_hsa047210.58534280
116Leishmaniasis_Homo sapiens_hsa051400.58428077
117Arachidonic acid metabolism_Homo sapiens_hsa005900.58004168
118MAPK signaling pathway_Homo sapiens_hsa040100.56994881
119Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.56908567
120Renal cell carcinoma_Homo sapiens_hsa052110.56892215
121NF-kappa B signaling pathway_Homo sapiens_hsa040640.56725130
122Biosynthesis of amino acids_Homo sapiens_hsa012300.56253801
123Intestinal immune network for IgA production_Homo sapiens_hsa046720.55999216
124Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54337346
125HTLV-I infection_Homo sapiens_hsa051660.53944242
126Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.53396919
127Caffeine metabolism_Homo sapiens_hsa002320.52476588
128Apoptosis_Homo sapiens_hsa042100.51769713
129Insulin resistance_Homo sapiens_hsa049310.51128195
130Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50798168
131ErbB signaling pathway_Homo sapiens_hsa040120.49884209
132Vibrio cholerae infection_Homo sapiens_hsa051100.49180098
133Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48240313
134Choline metabolism in cancer_Homo sapiens_hsa052310.47724855
135mTOR signaling pathway_Homo sapiens_hsa041500.47492395
136Glycerophospholipid metabolism_Homo sapiens_hsa005640.46458775
137Fatty acid elongation_Homo sapiens_hsa000620.45454438
138Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.44486505
139Thyroid cancer_Homo sapiens_hsa052160.44297695
140Glioma_Homo sapiens_hsa052140.44245650
141Acute myeloid leukemia_Homo sapiens_hsa052210.44225361
142Peroxisome_Homo sapiens_hsa041460.43564361
143Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.43461744
144NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43182911
145HIF-1 signaling pathway_Homo sapiens_hsa040660.42959050
146Endometrial cancer_Homo sapiens_hsa052130.42821771
147FoxO signaling pathway_Homo sapiens_hsa040680.41686126
148Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.40113479
149Fatty acid degradation_Homo sapiens_hsa000710.39687945
150Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38937653
151Pertussis_Homo sapiens_hsa051330.38494120
152Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.38078080
153Renin-angiotensin system_Homo sapiens_hsa046140.38054289
154Viral carcinogenesis_Homo sapiens_hsa052030.37763207
155beta-Alanine metabolism_Homo sapiens_hsa004100.36792900
156Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36683556
157Jak-STAT signaling pathway_Homo sapiens_hsa046300.36317655
158Selenocompound metabolism_Homo sapiens_hsa004500.36005860
159Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.34957702
160Influenza A_Homo sapiens_hsa051640.34356918
161Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.28522183
162Cardiac muscle contraction_Homo sapiens_hsa042600.28354604
163B cell receptor signaling pathway_Homo sapiens_hsa046620.26472437
164Allograft rejection_Homo sapiens_hsa053300.25609605
165Transcriptional misregulation in cancer_Homo sapiens_hsa052020.25242393
166Lysosome_Homo sapiens_hsa041420.25101791

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