MOB1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Three transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of execution phase of apoptosis (GO:1900118)4.89231246
2regulation of type B pancreatic cell apoptotic process (GO:2000674)4.80459620
3inositol phosphate catabolic process (GO:0071545)4.66115568
4cellular ketone body metabolic process (GO:0046950)4.55461856
5insulin secretion (GO:0030073)4.46292464
6regulation of hexokinase activity (GO:1903299)4.28094758
7regulation of glucokinase activity (GO:0033131)4.28094758
8phosphorylated carbohydrate dephosphorylation (GO:0046838)4.13244647
9inositol phosphate dephosphorylation (GO:0046855)4.13244647
10ketone body metabolic process (GO:1902224)4.11352293
11endocrine pancreas development (GO:0031018)4.03221287
12glycerophospholipid catabolic process (GO:0046475)4.00694162
13epithelial cell fate commitment (GO:0072148)4.00521291
14positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc3.93837258
15detection of calcium ion (GO:0005513)3.92870998
16polyol catabolic process (GO:0046174)3.91972908
17positive regulation of histone H3-K4 methylation (GO:0051571)3.82876074
18L-alpha-amino acid transmembrane transport (GO:1902475)3.79255312
19positive regulation of insulin secretion (GO:0032024)3.72802816
20signal peptide processing (GO:0006465)3.71241932
21lactate metabolic process (GO:0006089)3.69130249
22type B pancreatic cell development (GO:0003323)3.68740339
23positive regulation of gluconeogenesis (GO:0045722)3.65397020
24regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.57168402
25auditory receptor cell differentiation (GO:0042491)3.56746812
26positive regulation of macroautophagy (GO:0016239)3.51323815
27negative regulation of cytosolic calcium ion concentration (GO:0051481)3.48459222
28nitric oxide mediated signal transduction (GO:0007263)3.46299518
29peptide hormone processing (GO:0016486)3.45997200
30positive regulation of protein autophosphorylation (GO:0031954)3.43191911
31regulation of Rac protein signal transduction (GO:0035020)3.39665330
32kidney morphogenesis (GO:0060993)3.38819588
33protein prenylation (GO:0018342)3.37756387
34prenylation (GO:0097354)3.37756387
35protein carboxylation (GO:0018214)3.30871094
36peptidyl-glutamic acid carboxylation (GO:0017187)3.30871094
37positive regulation of response to extracellular stimulus (GO:0032106)3.29710698
38positive regulation of response to nutrient levels (GO:0032109)3.29710698
39positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003573.29226594
40tryptophan metabolic process (GO:0006568)3.28564250
41indole-containing compound catabolic process (GO:0042436)3.28180128
42indolalkylamine catabolic process (GO:0046218)3.28180128
43tryptophan catabolic process (GO:0006569)3.28180128
44positive regulation of peptide hormone secretion (GO:0090277)3.25320855
45aromatic amino acid family catabolic process (GO:0009074)3.21393194
46glandular epithelial cell differentiation (GO:0002067)3.19696952
47cell adhesion mediated by integrin (GO:0033627)3.17474291
48phospholipid dephosphorylation (GO:0046839)3.16432639
49homocysteine metabolic process (GO:0050667)3.16029561
50dentate gyrus development (GO:0021542)3.15250989
51negative regulation of hormone biosynthetic process (GO:0032353)3.15134322
52urea cycle (GO:0000050)3.13974012
53urea metabolic process (GO:0019627)3.13974012
54magnesium ion transport (GO:0015693)3.13822005
55protein targeting to Golgi (GO:0000042)3.13402795
56intra-Golgi vesicle-mediated transport (GO:0006891)3.13301291
57establishment of protein localization to Golgi (GO:0072600)3.11316595
58positive regulation of peptide secretion (GO:0002793)3.09741302
59dendritic spine morphogenesis (GO:0060997)3.08667012
60parental behavior (GO:0060746)3.07940209
61erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.07488596
62L-phenylalanine catabolic process (GO:0006559)3.07488596
63histamine secretion (GO:0001821)3.06654383
64regulation of bile acid biosynthetic process (GO:0070857)3.06355986
65cellular glucuronidation (GO:0052695)3.06120272
66synapsis (GO:0007129)3.03883193
67negative regulation of neurological system process (GO:0031645)3.02962090
68retrograde transport, vesicle recycling within Golgi (GO:0000301)3.00026984
69positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.96944681
70positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.96944681
71positive regulation of mitotic sister chromatid separation (GO:1901970)2.96944681
72uronic acid metabolic process (GO:0006063)2.96604909
73glucuronate metabolic process (GO:0019585)2.96604909
74bundle of His cell to Purkinje myocyte communication (GO:0086069)2.95412827
75cardiac left ventricle morphogenesis (GO:0003214)2.93194136
76astrocyte differentiation (GO:0048708)2.92903268
77positive regulation of calcium ion import (GO:0090280)2.92254227
78regulation of protein glycosylation (GO:0060049)2.90616345
79sphingosine metabolic process (GO:0006670)2.89138541
80peptide hormone secretion (GO:0030072)2.88762794
81regulation of insulin secretion (GO:0050796)2.87671048
82kynurenine metabolic process (GO:0070189)2.87426762
83phosphatidylinositol dephosphorylation (GO:0046856)2.87394006
84iron ion import (GO:0097286)2.86313912
85macroautophagy (GO:0016236)2.81802464
86peptide secretion (GO:0002790)2.81387193
87positive regulation of leukocyte degranulation (GO:0043302)2.81161416
88desmosome organization (GO:0002934)2.77889203
89cytoplasmic mRNA processing body assembly (GO:0033962)2.76852786
90zinc ion homeostasis (GO:0055069)2.75775456
91triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.74293325
92Golgi to endosome transport (GO:0006895)2.74089610
93negative regulation of protein oligomerization (GO:0032460)2.73249190
94nitrogen cycle metabolic process (GO:0071941)2.72628080
95cysteine metabolic process (GO:0006534)2.71887745
96positive regulation of glycolytic process (GO:0045821)2.71457887
97very-low-density lipoprotein particle assembly (GO:0034379)2.70697165
98regulation of triglyceride catabolic process (GO:0010896)2.69359831
99embryonic retina morphogenesis in camera-type eye (GO:0060059)2.67703646
100water-soluble vitamin biosynthetic process (GO:0042364)2.67171878
101brain morphogenesis (GO:0048854)2.66797761
102protein localization to cilium (GO:0061512)2.66676853
103positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.65779455
104protein localization to Golgi apparatus (GO:0034067)2.65558347
105positive regulation of hormone secretion (GO:0046887)2.65542753
106regulation of protein activation cascade (GO:2000257)2.64439405
107somite rostral/caudal axis specification (GO:0032525)2.63158539
108positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.62903874
109growth hormone receptor signaling pathway (GO:0060396)2.62442562
110regulation of fibrinolysis (GO:0051917)2.62202649
111epoxygenase P450 pathway (GO:0019373)2.62182886
112positive regulation of mast cell activation involved in immune response (GO:0033008)2.61900714
113positive regulation of mast cell degranulation (GO:0043306)2.61900714
114positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.61738081
115complement activation, alternative pathway (GO:0006957)2.61736701
116protein K11-linked deubiquitination (GO:0035871)2.61410215
117maternal behavior (GO:0042711)2.61385615
118regulation of peptide hormone secretion (GO:0090276)2.60486513
119nodal signaling pathway (GO:0038092)2.60224945
120positive regulation of fatty acid beta-oxidation (GO:0032000)2.59867545
121positive regulation of meiosis (GO:0045836)2.59440283
122fibrinolysis (GO:0042730)2.59237878
123platelet dense granule organization (GO:0060155)2.58884372
124positive regulation of lipid catabolic process (GO:0050996)2.58125381
125developmental pigmentation (GO:0048066)2.57317380
126phospholipid homeostasis (GO:0055091)2.56575358
127retinol metabolic process (GO:0042572)2.55984936
128plasma lipoprotein particle assembly (GO:0034377)2.55652923
129negative regulation of dendrite development (GO:2000171)2.55307173
130intestinal cholesterol absorption (GO:0030299)2.54746039
131xenobiotic catabolic process (GO:0042178)2.54744653
132hemidesmosome assembly (GO:0031581)2.53808644
133hormone catabolic process (GO:0042447)2.53096695
134regulation of sequestering of triglyceride (GO:0010889)2.52929138
135glyoxylate metabolic process (GO:0046487)2.52834066
136positive regulation of autophagy (GO:0010508)2.52625213
137regulation of peptide secretion (GO:0002791)2.52518130
138cholesterol efflux (GO:0033344)2.52233882
139prostate gland growth (GO:0060736)2.51796675
140L-phenylalanine metabolic process (GO:0006558)2.51781978
141erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.51781978
142respiratory chain complex IV assembly (GO:0008535)2.51599653
143regulation of complement activation (GO:0030449)2.50983908
144dopamine transport (GO:0015872)2.50095655
145zinc ion transport (GO:0006829)2.49985294
146calcium ion import (GO:0070509)2.48671480
147bile acid and bile salt transport (GO:0015721)2.48567997
148high-density lipoprotein particle remodeling (GO:0034375)2.47493216
149negative regulation of lipase activity (GO:0060192)2.47487048
150intestinal absorption (GO:0050892)2.47444675
151negative regulation of gluconeogenesis (GO:0045721)2.47344030
152response to pheromone (GO:0019236)2.47216790
153sulfur amino acid catabolic process (GO:0000098)2.47104729
154insulin-like growth factor receptor signaling pathway (GO:0048009)2.46911569
155amino-acid betaine metabolic process (GO:0006577)2.46414589
156keratinocyte development (GO:0003334)2.44626015
157negative regulation of fibrinolysis (GO:0051918)2.43192045
158phospholipid efflux (GO:0033700)2.42684936
159triglyceride homeostasis (GO:0070328)2.42637802
160acylglycerol homeostasis (GO:0055090)2.42637802
161diol metabolic process (GO:0034311)2.42203682
162regulation of hormone secretion (GO:0046883)2.39850997
163negative regulation of hormone metabolic process (GO:0032351)2.39641407
164regulation of membrane protein ectodomain proteolysis (GO:0051043)2.39014749
165indolalkylamine metabolic process (GO:0006586)2.37842659
166negative regulation of neurotransmitter transport (GO:0051589)2.37700997
167regulation of execution phase of apoptosis (GO:1900117)2.37654566
168bile acid biosynthetic process (GO:0006699)2.37206144
169drug catabolic process (GO:0042737)2.36491046
170protein-lipid complex assembly (GO:0065005)2.35346420
171plasma lipoprotein particle clearance (GO:0034381)2.34898558
172urate metabolic process (GO:0046415)2.34409460
173chemical homeostasis within a tissue (GO:0048875)2.34287226
174sterol homeostasis (GO:0055092)2.34229433
175lipoprotein metabolic process (GO:0042157)2.33784567
176midgut development (GO:0007494)2.32834193
177reverse cholesterol transport (GO:0043691)2.32711863
178lysine metabolic process (GO:0006553)2.32295930
179lysine catabolic process (GO:0006554)2.32295930
180surfactant homeostasis (GO:0043129)2.30645363
181histamine transport (GO:0051608)2.30320439
182cholesterol homeostasis (GO:0042632)2.30042734
183negative regulation of lipid storage (GO:0010888)2.29098201
184fatty acid transmembrane transport (GO:1902001)2.26670126
185flavonoid metabolic process (GO:0009812)2.25789538
186response to nitrosative stress (GO:0051409)2.25732177
187benzene-containing compound metabolic process (GO:0042537)2.25568932
188bile acid metabolic process (GO:0008206)2.25072650
189tyrosine metabolic process (GO:0006570)2.23582094
190regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.23403888
191regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.21801574
192regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.20608338
193regulation of cytokine secretion involved in immune response (GO:0002739)2.19125685
194L-ascorbic acid metabolic process (GO:0019852)2.19118871
195amine catabolic process (GO:0009310)2.18998591
196cellular biogenic amine catabolic process (GO:0042402)2.18998591
197positive regulation of hemostasis (GO:1900048)2.17662206
198positive regulation of blood coagulation (GO:0030194)2.17662206

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.45156667
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.42997580
3RXR_22158963_ChIP-Seq_LIVER_Mouse2.89921492
4LXR_22158963_ChIP-Seq_LIVER_Mouse2.85699554
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.77934888
6GBX2_23144817_ChIP-Seq_PC3_Human2.71998610
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.58821539
8CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.57169676
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.53512798
10EGR1_23403033_ChIP-Seq_LIVER_Mouse2.49299662
11PPARA_22158963_ChIP-Seq_LIVER_Mouse2.38523777
12IGF1R_20145208_ChIP-Seq_DFB_Human2.37692122
13ZNF217_24962896_ChIP-Seq_MCF-7_Human2.17829158
14NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.17264294
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.12105692
16FUS_26573619_Chip-Seq_HEK293_Human2.11902409
17Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.07017392
18SMAD_19615063_ChIP-ChIP_OVARY_Human2.02165749
19NRF2_20460467_ChIP-Seq_MEFs_Mouse1.98520099
20NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.98520099
21CDX2_19796622_ChIP-Seq_MESCs_Mouse1.95693307
22GATA1_22025678_ChIP-Seq_K562_Human1.95496146
23ZNF274_21170338_ChIP-Seq_K562_Hela1.94486484
24VDR_22108803_ChIP-Seq_LS180_Human1.93421475
25ESR1_20079471_ChIP-ChIP_T-47D_Human1.92130471
26RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.88435912
27STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.84757370
28EWS_26573619_Chip-Seq_HEK293_Human1.78078257
29AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.75687333
30SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.73741084
31EP300_21415370_ChIP-Seq_HL-1_Mouse1.72658018
32CJUN_26792858_Chip-Seq_BT549_Human1.71349460
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.70600956
34SALL1_21062744_ChIP-ChIP_HESCs_Human1.67563291
35STAT3_23295773_ChIP-Seq_U87_Human1.66297096
36ER_23166858_ChIP-Seq_MCF-7_Human1.64813630
37FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.63752485
38CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.63659594
39FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.62103412
40PCGF2_27294783_Chip-Seq_ESCs_Mouse1.61136014
41POU3F2_20337985_ChIP-ChIP_501MEL_Human1.59550572
42SALL4_18804426_ChIP-ChIP_XEN_Mouse1.59372895
43ESR1_21235772_ChIP-Seq_MCF-7_Human1.58995915
44TP53_16413492_ChIP-PET_HCT116_Human1.58661477
45HTT_18923047_ChIP-ChIP_STHdh_Human1.58298864
46AR_25329375_ChIP-Seq_VCAP_Human1.56281628
47FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.55866583
48NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.55695015
49SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.55617899
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.54748952
51PPAR_26484153_Chip-Seq_NCI-H1993_Human1.54028256
52EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.53421371
53FOXM1_26456572_ChIP-Seq_MCF-7_Human1.53311137
54CLOCK_20551151_ChIP-Seq_293T_Human1.52246971
55TCF4_23295773_ChIP-Seq_U87_Human1.50782568
56IRF8_22096565_ChIP-ChIP_GC-B_Human1.50771743
57ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.50504371
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.50400291
59WT1_19549856_ChIP-ChIP_CCG9911_Human1.46866142
60P53_22387025_ChIP-Seq_ESCs_Mouse1.46675018
61TP53_18474530_ChIP-ChIP_U2OS_Human1.45669887
62SMAD3_21741376_ChIP-Seq_EPCs_Human1.45436129
63STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.42939086
64FOXO3_23340844_ChIP-Seq_DLD1_Human1.42700068
65CMYC_18555785_Chip-Seq_ESCs_Mouse1.41618444
66SOX2_20726797_ChIP-Seq_SW620_Human1.41329175
67SUZ12_18555785_Chip-Seq_ESCs_Mouse1.40172737
68TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.39989735
69AHR_22903824_ChIP-Seq_MCF-7_Human1.39857448
70SOX2_27498859_Chip-Seq_STOMACH_Mouse1.38668048
71RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.36571963
72GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36273117
73FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.36104266
74EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.35917899
75GATA4_25053715_ChIP-Seq_YYC3_Human1.35491361
76STAT3_18555785_Chip-Seq_ESCs_Mouse1.35405784
77SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.35215003
78SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.35215003
79CTBP1_25329375_ChIP-Seq_LNCAP_Human1.34252280
80SOX9_24532713_ChIP-Seq_HFSC_Mouse1.32900340
81BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.30591159
82TCF4_18268006_ChIP-ChIP_LS174T_Human1.30292893
83UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.28933682
84FOXA2_19822575_ChIP-Seq_HepG2_Human1.28285801
85FLI1_21867929_ChIP-Seq_TH2_Mouse1.27266699
86SOX2_18555785_Chip-Seq_ESCs_Mouse1.26405577
87AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.24243670
88TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23514055
89CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.23170937
90RXR_22108803_ChIP-Seq_LS180_Human1.22838027
91CRX_20693478_ChIP-Seq_RETINA_Mouse1.22746435
92TP63_23658742_ChIP-Seq_EP156T_Human1.21861063
93IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.21575545
94NR3C1_23031785_ChIP-Seq_PC12_Mouse1.20922158
95P300_18555785_Chip-Seq_ESCs_Mouse1.19654474
96ARNT_22903824_ChIP-Seq_MCF-7_Human1.19346792
97BRD4_25478319_ChIP-Seq_HGPS_Human1.18890281
98OCT4_21477851_ChIP-Seq_ESCs_Mouse1.17161940
99BCAT_22108803_ChIP-Seq_LS180_Human1.16944535
100NMYC_18555785_Chip-Seq_ESCs_Mouse1.16934677
101OCT4_18555785_Chip-Seq_ESCs_Mouse1.16142156
102NANOG_19829295_ChIP-Seq_ESCs_Human1.14805701
103SOX2_19829295_ChIP-Seq_ESCs_Human1.14805701
104TP53_22573176_ChIP-Seq_HFKS_Human1.13884673
105TAL1_26923725_Chip-Seq_HPCs_Mouse1.12036390
106TCF4_22108803_ChIP-Seq_LS180_Human1.11709308
107IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.11217224
108CBP_20019798_ChIP-Seq_JUKART_Human1.11217224
109CTCF_18555785_Chip-Seq_ESCs_Mouse1.11089779
110RUNX2_22187159_ChIP-Seq_PCA_Human1.11082225
111ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11041373
112GATA2_21666600_ChIP-Seq_HMVEC_Human1.10459299
113VDR_24787735_ChIP-Seq_THP-1_Human1.09977319
114SOX2_21211035_ChIP-Seq_LN229_Gbm1.09781099
115STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.09401536
116EGR1_19374776_ChIP-ChIP_THP-1_Human1.08196779
117TBL1_22424771_ChIP-Seq_293T_Human1.07574706
118MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07256950
119TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06935160
120FOXA1_21572438_ChIP-Seq_LNCaP_Human1.06819616
121MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06556133
122FOXA1_25552417_ChIP-Seq_VCAP_Human1.05719472
123ESR2_21235772_ChIP-Seq_MCF-7_Human1.05529130
124PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05266076
125TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.04833848
126FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.03946592
127SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02953985
128FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.02879557
129HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.02787432
130P300_19829295_ChIP-Seq_ESCs_Human1.02540659
131PU1_27457419_Chip-Seq_LIVER_Mouse1.02164628
132PRDM14_20953172_ChIP-Seq_ESCs_Human1.02158989
133ISL1_27105846_Chip-Seq_CPCs_Mouse1.01961524
134EZH2_27294783_Chip-Seq_NPCs_Mouse1.00984517
135FOXA1_27270436_Chip-Seq_PROSTATE_Human1.00740603
136FOXA1_25329375_ChIP-Seq_VCAP_Human1.00740603
137PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.00723113
138TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00366699
139CDX2_22108803_ChIP-Seq_LS180_Human1.00336407
140SMAD4_21741376_ChIP-Seq_EPCs_Human0.99774168
141RUNX1_27457419_Chip-Seq_LIVER_Mouse0.99766674
142SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.99763303
143NFYB_21822215_ChIP-Seq_K562_Human0.99240064
144EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.97760893
145RARG_19884340_ChIP-ChIP_MEFs_Mouse0.97192469
146CDX2_20551321_ChIP-Seq_CACO-2_Human0.96285138
147ZFX_18555785_Chip-Seq_ESCs_Mouse0.96089591
148NANOG_18555785_Chip-Seq_ESCs_Mouse0.95918867
149GATA6_25053715_ChIP-Seq_YYC3_Human0.95887826
150EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95866233
151E2F1_18555785_Chip-Seq_ESCs_Mouse0.95421017
152NFE2_27457419_Chip-Seq_LIVER_Mouse0.94541406
153TAF15_26573619_Chip-Seq_HEK293_Human0.94463899
154SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.94382104
155SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.93572302
156PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.93085759
157NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92913217
158GATA3_24758297_ChIP-Seq_MCF-7_Human0.92898261
159SMAD4_21799915_ChIP-Seq_A2780_Human0.92603807
160OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92339582
161BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.91636426
162CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.91548798
163NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.91394356
164JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91183928

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.01427648
2MP0005360_urolithiasis4.28364303
3MP0002139_abnormal_hepatobiliary_system4.00151789
4MP0005085_abnormal_gallbladder_physiolo3.64055752
5MP0005379_endocrine/exocrine_gland_phen3.49523921
6MP0005365_abnormal_bile_salt3.39899135
7MP0003787_abnormal_imprinting3.32467366
8MP0004147_increased_porphyrin_level3.08573870
9MP0003252_abnormal_bile_duct3.03521350
10MP0008877_abnormal_DNA_methylation3.03261752
11MP0002909_abnormal_adrenal_gland2.87441134
12MP0008875_abnormal_xenobiotic_pharmacok2.68135317
13MP0008057_abnormal_DNA_replication2.68004232
14MP0005451_abnormal_body_composition2.50862979
15MP0001944_abnormal_pancreas_morphology2.48344843
16MP0003705_abnormal_hypodermis_morpholog2.46620391
17MP0000013_abnormal_adipose_tissue2.44890240
18MP0002163_abnormal_gland_morphology2.39052748
19MP0005248_abnormal_Harderian_gland2.36825133
20MP0002693_abnormal_pancreas_physiology2.33253250
21MP0005645_abnormal_hypothalamus_physiol2.28022186
22MP0003122_maternal_imprinting2.14704253
23MP0010234_abnormal_vibrissa_follicle2.13623499
24MP0003941_abnormal_skin_development2.01738980
25MP0000383_abnormal_hair_follicle2.00292125
26MP0010678_abnormal_skin_adnexa1.96976189
27MP0006072_abnormal_retinal_apoptosis1.93068988
28MP0003283_abnormal_digestive_organ1.88481657
29MP0003300_gastrointestinal_ulcer1.87906549
30MP0002638_abnormal_pupillary_reflex1.85012309
31MP0010329_abnormal_lipoprotein_level1.79075233
32MP0009384_cardiac_valve_regurgitation1.78093164
33MP0005275_abnormal_skin_tensile1.77370508
34MP0001666_abnormal_nutrient_absorption1.72810233
35MP0005174_abnormal_tail_pigmentation1.67979264
36MP0000569_abnormal_digit_pigmentation1.67881539
37MP0005646_abnormal_pituitary_gland1.67474341
38MP0005076_abnormal_cell_differentiation1.62457811
39MP0003566_abnormal_cell_adhesion1.61331911
40MP0001346_abnormal_lacrimal_gland1.60598719
41MP0005408_hypopigmentation1.60345963
42MP0002009_preneoplasia1.59085882
43MP0009046_muscle_twitch1.59054505
44MP0003172_abnormal_lysosome_physiology1.57732796
45MP0002138_abnormal_hepatobiliary_system1.56358271
46MP0000566_synostosis1.56159099
47MP0002098_abnormal_vibrissa_morphology1.54563860
48MP0005083_abnormal_biliary_tract1.53907990
49MP0002078_abnormal_glucose_homeostasis1.52460093
50MP0002254_reproductive_system_inflammat1.51533655
51MP0004782_abnormal_surfactant_physiolog1.46095798
52MP0004885_abnormal_endolymph1.44402317
53MP0004264_abnormal_extraembryonic_tissu1.43693292
54MP0001984_abnormal_olfaction1.41593607
55MP0008438_abnormal_cutaneous_collagen1.41052709
56MP0009764_decreased_sensitivity_to1.40608470
57MP0002877_abnormal_melanocyte_morpholog1.40449971
58MP0010352_gastrointestinal_tract_polyps1.38419689
59MP0003121_genomic_imprinting1.38152851
60MP0002060_abnormal_skin_morphology1.36174378
61MP0001756_abnormal_urination1.35106620
62MP0005075_abnormal_melanosome_morpholog1.34707222
63MP0000015_abnormal_ear_pigmentation1.33591661
64MP0004215_abnormal_myocardial_fiber1.33233043
65MP0009697_abnormal_copulation1.32798395
66MP0003195_calcinosis1.32112112
67MP0005367_renal/urinary_system_phenotyp1.31548813
68MP0000516_abnormal_urinary_system1.31548813
69MP0000427_abnormal_hair_cycle1.31514783
70MP0005636_abnormal_mineral_homeostasis1.30395296
71MP0010368_abnormal_lymphatic_system1.28842476
72MP0002876_abnormal_thyroid_physiology1.28621509
73MP0003453_abnormal_keratinocyte_physiol1.26456622
74MP0004019_abnormal_vitamin_homeostasis1.24950227
75MP0006054_spinal_hemorrhage1.24506321
76MP0002796_impaired_skin_barrier1.23753299
77MP0005332_abnormal_amino_acid1.23198965
78MP0000609_abnormal_liver_physiology1.22673613
79MP0005253_abnormal_eye_physiology1.22610839
80MP0005551_abnormal_eye_electrophysiolog1.19750976
81MP0003828_pulmonary_edema1.18983730
82MP0001881_abnormal_mammary_gland1.17681370
83MP0004272_abnormal_basement_membrane1.17000865
84MP0005647_abnormal_sex_gland1.16500507
85MP0000627_abnormal_mammary_gland1.13750326
86MP0009053_abnormal_anal_canal1.12276110
87MP0004270_analgesia1.10039141
88MP0002938_white_spotting1.08225865
89MP0003656_abnormal_erythrocyte_physiolo1.07340122
90MP0005448_abnormal_energy_balance1.06749303
91MP0002090_abnormal_vision1.05995492
92MP0003890_abnormal_embryonic-extraembry1.05938662
93MP0005535_abnormal_body_temperature1.05716678
94MP0005464_abnormal_platelet_physiology1.05223187
95MP0002102_abnormal_ear_morphology1.04695036
96MP0000579_abnormal_nail_morphology1.04545967
97MP0001216_abnormal_epidermal_layer1.01527839
98MP0002118_abnormal_lipid_homeostasis1.00871095
99MP0004043_abnormal_pH_regulation0.99394616
100MP0000647_abnormal_sebaceous_gland0.99375070
101MP0003953_abnormal_hormone_level0.97660142
102MP0000377_abnormal_hair_follicle0.96322243
103MP0004947_skin_inflammation0.93722036
104MP0010386_abnormal_urinary_bladder0.93573678
105MP0000538_abnormal_urinary_bladder0.92768277
106MP0000631_abnormal_neuroendocrine_gland0.92605946
107MP0002166_altered_tumor_susceptibility0.90935928
108MP0005386_behavior/neurological_phenoty0.90646492
109MP0004924_abnormal_behavior0.90646492
110MP0004085_abnormal_heartbeat0.90348713
111MP0000230_abnormal_systemic_arterial0.90283177
112MP0001879_abnormal_lymphatic_vessel0.89666633
113MP0001765_abnormal_ion_homeostasis0.89026813
114MP0005257_abnormal_intraocular_pressure0.88495336
115MP0003091_abnormal_cell_migration0.86855045
116MP0000537_abnormal_urethra_morphology0.86521590
117MP0004185_abnormal_adipocyte_glucose0.85846624
118MP0003868_abnormal_feces_composition0.85805268
119MP0003123_paternal_imprinting0.84386323
120MP0002972_abnormal_cardiac_muscle0.84384946
121MP0000767_abnormal_smooth_muscle0.84242026
122MP0009745_abnormal_behavioral_response0.84063594
123MP0002896_abnormal_bone_mineralization0.83996383
124MP0009643_abnormal_urine_homeostasis0.83514664
125MP0004142_abnormal_muscle_tone0.83383320
126MP0005319_abnormal_enzyme/_coenzyme0.82271877
127MP0002928_abnormal_bile_duct0.81152318
128MP0000372_irregular_coat_pigmentation0.80423185
129MP0004134_abnormal_chest_morphology0.80362059
130MP0002168_other_aberrant_phenotype0.79136223
131MP0002006_tumorigenesis0.77219963
132MP0000733_abnormal_muscle_development0.76956734
133MP0010630_abnormal_cardiac_muscle0.76880914
134MP0000639_abnormal_adrenal_gland0.76778993
135MP0001191_abnormal_skin_condition0.76126025
136MP0003633_abnormal_nervous_system0.75271696
137MP0005220_abnormal_exocrine_pancreas0.74542875
138MP0004084_abnormal_cardiac_muscle0.73436538
139MP0008775_abnormal_heart_ventricle0.72895062
140MP0008961_abnormal_basal_metabolism0.72827986
141MP0008004_abnormal_stomach_pH0.72684411
142MP0002095_abnormal_skin_pigmentation0.72567313
143MP0002557_abnormal_social/conspecific_i0.71006478
144MP0005187_abnormal_penis_morphology0.70708033
145MP0005334_abnormal_fat_pad0.70248165
146MP0003045_fibrosis0.69753075
147MP0000003_abnormal_adipose_tissue0.69556497
148MP0004130_abnormal_muscle_cell0.68259308
149MP0001986_abnormal_taste_sensitivity0.68223215
150MP0005501_abnormal_skin_physiology0.68123648
151MP0002229_neurodegeneration0.67549147
152MP0005503_abnormal_tendon_morphology0.67146802
153MP0001970_abnormal_pain_threshold0.66797598
154MP0008872_abnormal_physiological_respon0.66614590
155MP0000598_abnormal_liver_morphology0.65929918
156MP0004133_heterotaxia0.65895803
157MP0009780_abnormal_chondrocyte_physiolo0.65766589
158MP0003115_abnormal_respiratory_system0.64502989
159MP0009931_abnormal_skin_appearance0.63469202
160MP0002133_abnormal_respiratory_system0.62199419
161MP0005388_respiratory_system_phenotype0.62199419
162MP0002295_abnormal_pulmonary_circulatio0.62169184
163MP0005084_abnormal_gallbladder_morpholo0.61714903
164MP0001661_extended_life_span0.60355096
165MP0004510_myositis0.60294385
166MP0004036_abnormal_muscle_relaxation0.60029103
167MP0008995_early_reproductive_senescence0.59991670
168MP0002272_abnormal_nervous_system0.59954740
169MP0002064_seizures0.59707964

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)4.67455279
2Right ventricular cardiomyopathy (HP:0011663)3.99759647
3Deep venous thrombosis (HP:0002625)3.72168864
4Large for gestational age (HP:0001520)3.64390610
5Intestinal atresia (HP:0011100)3.49530887
6Thick nail (HP:0001805)3.47043040
7Hypothermia (HP:0002045)3.44327946
8Intrahepatic cholestasis (HP:0001406)3.43261927
9Prolonged partial thromboplastin time (HP:0003645)3.35602526
10Abnormality of the pancreatic islet cells (HP:0006476)3.34501567
11Abnormality of endocrine pancreas physiology (HP:0012093)3.34501567
12Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.32056204
13Xanthomatosis (HP:0000991)3.19672348
14Hemiparesis (HP:0001269)3.17593999
15Enlarged penis (HP:0000040)3.14202921
16Abnormality of glutamine family amino acid metabolism (HP:0010902)3.09140782
17Abnormality of the renal cortex (HP:0011035)3.08892168
18Hyperglycemia (HP:0003074)3.06494791
19Epidermoid cyst (HP:0200040)2.95004450
20Pancreatic islet-cell hyperplasia (HP:0004510)2.94985772
21Hypomagnesemia (HP:0002917)2.93088054
22Increased circulating renin level (HP:0000848)2.87766866
23Myocardial infarction (HP:0001658)2.86262586
24Abnormality of vitamin B metabolism (HP:0004340)2.85344764
25Abnormality of the common coagulation pathway (HP:0010990)2.82554222
26Hyperthyroidism (HP:0000836)2.79231482
27Abnormality of monocarboxylic acid metabolism (HP:0010996)2.77753488
28Hepatocellular carcinoma (HP:0001402)2.77051676
29Subacute progressive viral hepatitis (HP:0006572)2.74369612
30Prolonged bleeding time (HP:0003010)2.73156919
31Acanthocytosis (HP:0001927)2.71770485
32Thyroid carcinoma (HP:0002890)2.70776271
33Renal cortical cysts (HP:0000803)2.70293995
34Conjugated hyperbilirubinemia (HP:0002908)2.70250986
35Increased CSF protein (HP:0002922)2.70068711
36Abnormality of the heme biosynthetic pathway (HP:0010472)2.69180658
37Hypoglycemic coma (HP:0001325)2.66860121
38Hypobetalipoproteinemia (HP:0003563)2.66764417
39Pancreatic fibrosis (HP:0100732)2.65340023
40Complement deficiency (HP:0004431)2.63343901
41Neoplasm of the adrenal cortex (HP:0100641)2.62111364
42Testicular neoplasm (HP:0010788)2.56997555
43Hypoalphalipoproteinemia (HP:0003233)2.56756075
44Lip pit (HP:0100267)2.56427100
45Pancreatic cysts (HP:0001737)2.54399758
46Fat malabsorption (HP:0002630)2.52828778
47Abnormal biliary tract morphology (HP:0012440)2.52235438
48Urethral obstruction (HP:0000796)2.51972664
49Hydroxyprolinuria (HP:0003080)2.51856603
50Abnormality of proline metabolism (HP:0010907)2.51856603
51Abnormal drinking behavior (HP:0030082)2.48290541
52Polydipsia (HP:0001959)2.48290541
53Hypolipoproteinemia (HP:0010981)2.47914443
54Osteolytic defects of the phalanges of the hand (HP:0009771)2.45157894
55Osteolytic defects of the hand bones (HP:0009699)2.45157894
56Abnormality of purine metabolism (HP:0004352)2.44732841
57EEG with generalized epileptiform discharges (HP:0011198)2.44123208
58Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.43768115
59Abnormality of the intrinsic pathway (HP:0010989)2.43569726
60Tubular atrophy (HP:0000092)2.42664937
61Conjunctival hamartoma (HP:0100780)2.41668751
62Abnormality of aromatic amino acid family metabolism (HP:0004338)2.39461212
63Epileptiform EEG discharges (HP:0011182)2.36184336
64Nephronophthisis (HP:0000090)2.34063435
65Aplasia/Hypoplasia of the fovea (HP:0008060)2.33711765
66Hypoplasia of the fovea (HP:0007750)2.33711765
67Abnormality of calcium-phosphate metabolism (HP:0100530)2.33391802
68Atrophic scars (HP:0001075)2.32842974
69Esophageal varix (HP:0002040)2.32524735
70Abnormality of vitamin metabolism (HP:0100508)2.32287155
71Abnormality of incisor morphology (HP:0011063)2.32221844
72Hypsarrhythmia (HP:0002521)2.31912082
73Hamartoma of the eye (HP:0010568)2.30688151
74Pigmentary retinal degeneration (HP:0001146)2.29270119
75Neoplasm of the tracheobronchial system (HP:0100552)2.29246975
76Alveolar cell carcinoma (HP:0006519)2.29019712
77Chorioretinal atrophy (HP:0000533)2.28408276
78Thyroiditis (HP:0100646)2.27906994
79Hypochromic microcytic anemia (HP:0004840)2.27566014
80Hyperlipoproteinemia (HP:0010980)2.26299146
81Agitation (HP:0000713)2.25629498
82Hypercholesterolemia (HP:0003124)2.23766594
83Aqueductal stenosis (HP:0002410)2.23414466
84Hypophosphatemic rickets (HP:0004912)2.22771854
85Abnormality of the renal medulla (HP:0100957)2.22068927
86Joint hemorrhage (HP:0005261)2.22048113
87Macroorchidism (HP:0000053)2.19843941
88Aortic aneurysm (HP:0004942)2.19277220
89Methylmalonic acidemia (HP:0002912)2.18661675
90Orthostatic hypotension (HP:0001278)2.18441397
91Aplasia cutis congenita (HP:0001057)2.17749278
92Hyporeflexia of lower limbs (HP:0002600)2.16965225
93Alopecia of scalp (HP:0002293)2.15998277
94Congenital sensorineural hearing impairment (HP:0008527)2.15607544
95Hypoglycemic seizures (HP:0002173)2.15476522
96Double outlet right ventricle (HP:0001719)2.15086963
97Congenital malformation of the right heart (HP:0011723)2.15086963
98Abnormality of the nasal septum (HP:0000419)2.14327008
99Albinism (HP:0001022)2.13334496
100Cardiovascular calcification (HP:0011915)2.12883250
101Skin nodule (HP:0200036)2.11845038
102Hemorrhage of the eye (HP:0011885)2.11770634
103Late onset (HP:0003584)2.11004822
104Hypoplastic ischia (HP:0003175)2.08340648
105Petechiae (HP:0000967)2.08153972
106Abnormality of sulfur amino acid metabolism (HP:0004339)2.07866966
107Gaze-evoked nystagmus (HP:0000640)2.06924488
108Bilateral sensorineural hearing impairment (HP:0008619)2.06548839
109Cone-rod dystrophy (HP:0000548)2.06455854
110Neoplasm of the thyroid gland (HP:0100031)2.01618194
111Ketosis (HP:0001946)2.00971561
112Vascular calcification (HP:0004934)2.00853089
113Submucous cleft hard palate (HP:0000176)2.00849295
114Onycholysis (HP:0001806)2.00846731
115Prominent metopic ridge (HP:0005487)2.00691422
116Congenital stationary night blindness (HP:0007642)2.00624323
117Hyperglycinemia (HP:0002154)1.99931840
118Hyperkalemia (HP:0002153)1.99822291
119Postural tremor (HP:0002174)1.99783791
120Biliary tract neoplasm (HP:0100574)1.98396605
121Hypoplastic labia majora (HP:0000059)1.96437072
122Hyperglycinuria (HP:0003108)1.96377756
123Tongue fasciculations (HP:0001308)1.96042940
124Insulin-resistant diabetes mellitus (HP:0000831)1.95719621
125Furrowed tongue (HP:0000221)1.95487758
126Medial flaring of the eyebrow (HP:0010747)1.94138962
127Downturned corners of mouth (HP:0002714)1.92908021
128Poikilocytosis (HP:0004447)1.92019354
129Absent eyebrow (HP:0002223)1.90761335
130Abnormality of the metopic suture (HP:0005556)1.90427809
131Metaphyseal dysplasia (HP:0100255)1.89993421
132Milia (HP:0001056)1.89864286
133Abnormality of the ischium (HP:0003174)1.88923893
134Widely spaced teeth (HP:0000687)1.88486260
135Volvulus (HP:0002580)1.87627389
136Abnormality of nucleobase metabolism (HP:0010932)1.87165551
137Abnormal rod and cone electroretinograms (HP:0008323)1.86786126
138Abnormality of magnesium homeostasis (HP:0004921)1.85510734
139Abnormality of urine glucose concentration (HP:0011016)1.84703839
140Glycosuria (HP:0003076)1.84703839
141Hyperventilation (HP:0002883)1.84078668
142True hermaphroditism (HP:0010459)1.83767766
143Neuroendocrine neoplasm (HP:0100634)1.83617220
144Natal tooth (HP:0000695)1.83554675
145Abnormality of the fovea (HP:0000493)1.82891037
146Spinal cord lesions (HP:0100561)1.82716847
147Syringomyelia (HP:0003396)1.82716847
148Abnormality of complement system (HP:0005339)1.82347448
149Abnormality of the labia majora (HP:0012881)1.81935497
150Pheochromocytoma (HP:0002666)1.81299337
151Progressive macrocephaly (HP:0004481)1.80883336
152Tetraparesis (HP:0002273)1.80522767
153Disproportionate short-trunk short stature (HP:0003521)1.80009531
154Fair hair (HP:0002286)1.79990341
155Abnormality of aspartate family amino acid metabolism (HP:0010899)1.79918838
156Ketoacidosis (HP:0001993)1.79405523
157Asymmetry of the thorax (HP:0001555)1.79226339
158Abnormality of midbrain morphology (HP:0002418)1.78827309
159Molar tooth sign on MRI (HP:0002419)1.78827309
160Autoimmune thrombocytopenia (HP:0001973)1.77859621
161Muscular hypotonia of the trunk (HP:0008936)1.76661120
162Mitral stenosis (HP:0001718)1.75920277
163Neoplasm of the adrenal gland (HP:0100631)1.75629699
164Abnormality of chloride homeostasis (HP:0011422)1.75538407
165Progressive neurologic deterioration (HP:0002344)1.75454045
166Cutaneous melanoma (HP:0012056)1.75401832
167Recurrent gram-negative bacterial infections (HP:0005420)1.74265179
168Steatorrhea (HP:0002570)1.74020582
169Advanced eruption of teeth (HP:0006288)1.73951317
170Plantar hyperkeratosis (HP:0007556)1.73421971
171Abnormality of serine family amino acid metabolism (HP:0010894)1.72902617
172Abnormality of glycine metabolism (HP:0010895)1.72902617
173Neoplasm of the oral cavity (HP:0100649)1.72590528
174Osteomalacia (HP:0002749)1.72490771
175Meningioma (HP:0002858)1.72113740
176Papillary thyroid carcinoma (HP:0002895)1.71350475
177Severe Myopia (HP:0011003)1.71080453
178Hematochezia (HP:0002573)1.70657410
179Increased mean platelet volume (HP:0011877)1.70555082
180Premature rupture of membranes (HP:0001788)1.69010549
181Menorrhagia (HP:0000132)1.68803809
182Rickets (HP:0002748)1.66950459
183Symptomatic seizures (HP:0011145)1.62620156
184Abnormality of fatty-acid metabolism (HP:0004359)1.62205328
185Proximal tubulopathy (HP:0000114)1.61059981
186Aneurysm (HP:0002617)1.59798896

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS15.05062830
2FRK3.15885192
3INSRR2.92636441
4NUAK12.83649392
5MAP4K22.57322659
6OBSCN2.51117008
7SIK12.33735392
8WNK32.15487859
9MAP3K142.14465228
10TNIK2.13340508
11ERBB42.05791390
12* STK32.05161251
13TAOK31.97671941
14STK38L1.91582032
15EIF2AK11.90214452
16MST41.85498446
17NTRK31.83844337
18STK241.80153904
19MAP3K41.79045643
20MST1R1.76335090
21CDK121.71729201
22ERBB31.70764277
23ZAK1.67751819
24PHKG11.67188053
25PHKG21.67188053
26TRPM71.66080926
27EPHA21.64879147
28NLK1.60660351
29AKT31.60618689
30NEK91.58227003
31ADRBK21.52334871
32PIK3CA1.51598137
33CDK61.49343656
34EPHB21.44103151
35GRK11.42190088
36WNK41.36038082
37STK391.33711772
38MAP3K31.33635910
39CAMK1D1.32125416
40EPHB11.31425547
41CASK1.30969563
42DAPK21.29014192
43PNCK1.22443483
44EPHA31.21718184
45MAP3K21.21614830
46PTK61.21070977
47MAP2K61.20052294
48EIF2AK31.19077328
49PLK31.18053651
50PIK3CG1.17665903
51BMPR1B1.15974953
52DMPK1.15368386
53FER1.13857966
54BCR1.13559378
55PBK1.09331711
56ERBB21.09032845
57RIPK11.08846172
58MET1.07460904
59IRAK31.07296710
60CHUK1.07286380
61JAK11.03182496
62SIK31.03063115
63TRIM281.00361975
64PINK10.98836713
65MELK0.98380832
66RPS6KA40.96731085
67MAP3K50.96232873
68HIPK20.94157865
69ERN10.93920645
70OXSR10.91769006
71FGFR30.91302659
72PASK0.90665008
73CSNK1G10.90635605
74MKNK10.89679271
75JAK30.89421671
76BMPR20.87795485
77TYK20.87762331
78SGK20.87087272
79PRKAA20.85747505
80TGFBR20.84789479
81SGK30.84593315
82BRSK20.83326043
83ACVR1B0.83228675
84PTK20.81098144
85EIF2AK20.80468462
86BRD40.79318921
87TEC0.75563534
88TAOK10.74370053
89TTN0.74009660
90PDGFRB0.73152410
91CSNK1G20.71709551
92PRKCG0.69858009
93STK110.68087168
94FGFR40.67639406
95CAMK1G0.66846285
96IRAK10.63606057
97CAMK2D0.63323785
98MAP3K60.63017329
99MAP2K70.62903061
100EGFR0.61184779
101CAMKK20.61108901
102FGFR20.61034086
103CSNK1G30.60411477
104JAK20.59903588
105STK100.59312677
106PAK30.58733931
107GSK3A0.57394128
108MKNK20.56812320
109IKBKB0.56425759
110CDK90.56340030
111MAP2K40.52729153
112FGFR10.52380155
113PRKCE0.52205727
114PRKAA10.51944871
115PDGFRA0.51278681
116PRKG10.50946230
117MAP2K10.50181779
118DDR20.49740031
119PKN20.49319276
120PLK20.48790576
121MAP3K70.47858395
122ABL10.47607539
123IGF1R0.46684944
124PRKCQ0.46618790
125WNK10.46303619
126ATM0.45510826
127MTOR0.45101950
128MAPK130.45091379
129MARK30.45041404
130TBK10.43888239
131PTK2B0.43079802
132ADRBK10.42504563
133ABL20.42020467
134LATS20.40963175
135PLK40.40736153
136BMX0.40429027
137IKBKE0.39986349
138FGR0.36820634
139ROCK10.36284033
140SGK10.35503441
141CDK30.34585212
142CDC42BPA0.34211215
143CSNK1D0.33080088
144PRKACB0.32553859
145YES10.32537645
146MAP3K120.31573883
147KSR10.31086674
148PRKACG0.28594139
149CSNK1A1L0.27919172
150PRKACA0.26085695
151PRKCI0.24799828
152TNK20.23232605
153CSNK1E0.22497209
154CSNK1A10.22126846
155CAMK2A0.21495663
156PRKCB0.20611362
157STK380.19019158
158SGK2230.18827002

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.37414315
2Protein export_Homo sapiens_hsa030603.16136487
3Insulin secretion_Homo sapiens_hsa049112.74946440
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.72819900
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.64610597
6Complement and coagulation cascades_Homo sapiens_hsa046102.22781851
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.12083536
8Tryptophan metabolism_Homo sapiens_hsa003802.10516329
9Pentose and glucuronate interconversions_Homo sapiens_hsa000402.09885562
10Collecting duct acid secretion_Homo sapiens_hsa049662.09635682
11Caffeine metabolism_Homo sapiens_hsa002322.09488997
12Fatty acid degradation_Homo sapiens_hsa000711.96059332
13Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.91580428
14Vitamin B6 metabolism_Homo sapiens_hsa007501.91336828
15Regulation of autophagy_Homo sapiens_hsa041401.85624611
16Sulfur metabolism_Homo sapiens_hsa009201.82542989
17Arginine biosynthesis_Homo sapiens_hsa002201.82009564
18Folate biosynthesis_Homo sapiens_hsa007901.71703735
19Chemical carcinogenesis_Homo sapiens_hsa052041.68816199
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.66391329
21Sphingolipid metabolism_Homo sapiens_hsa006001.64019412
22Staphylococcus aureus infection_Homo sapiens_hsa051501.62716560
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.62346755
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.61541789
25PPAR signaling pathway_Homo sapiens_hsa033201.57338297
26Adherens junction_Homo sapiens_hsa045201.53324182
27Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.51555263
28Propanoate metabolism_Homo sapiens_hsa006401.48445970
29Starch and sucrose metabolism_Homo sapiens_hsa005001.48146223
30Phototransduction_Homo sapiens_hsa047441.48033743
31Peroxisome_Homo sapiens_hsa041461.45055750
32Histidine metabolism_Homo sapiens_hsa003401.43964689
33Nitrogen metabolism_Homo sapiens_hsa009101.39723734
34SNARE interactions in vesicular transport_Homo sapiens_hsa041301.37749039
35beta-Alanine metabolism_Homo sapiens_hsa004101.37285197
36Lysine degradation_Homo sapiens_hsa003101.35395352
37Phenylalanine metabolism_Homo sapiens_hsa003601.33541093
38Retinol metabolism_Homo sapiens_hsa008301.33076254
39ABC transporters_Homo sapiens_hsa020101.31233818
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.29836358
41Fatty acid metabolism_Homo sapiens_hsa012121.28536459
42Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.26663543
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.25397282
44Maturity onset diabetes of the young_Homo sapiens_hsa049501.23391759
45Renin secretion_Homo sapiens_hsa049241.21725834
46Ether lipid metabolism_Homo sapiens_hsa005651.21646932
47Butanoate metabolism_Homo sapiens_hsa006501.17733704
48Long-term depression_Homo sapiens_hsa047301.17303635
49Circadian entrainment_Homo sapiens_hsa047131.15857384
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.14317295
51Non-homologous end-joining_Homo sapiens_hsa034501.13932996
52Bile secretion_Homo sapiens_hsa049761.10661260
53Serotonergic synapse_Homo sapiens_hsa047261.10447567
54Type I diabetes mellitus_Homo sapiens_hsa049401.09378487
55Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.09091470
56Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.06603412
57Vitamin digestion and absorption_Homo sapiens_hsa049771.06278516
58Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.05599023
59Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.05318292
60ECM-receptor interaction_Homo sapiens_hsa045121.03382028
61Mineral absorption_Homo sapiens_hsa049781.03371524
62Insulin resistance_Homo sapiens_hsa049311.02480167
63Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.01502257
64Selenocompound metabolism_Homo sapiens_hsa004500.98443436
65Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.96922216
66Tyrosine metabolism_Homo sapiens_hsa003500.95972960
67Amoebiasis_Homo sapiens_hsa051460.93906571
68TGF-beta signaling pathway_Homo sapiens_hsa043500.93802115
69Dopaminergic synapse_Homo sapiens_hsa047280.92919238
70TNF signaling pathway_Homo sapiens_hsa046680.88881093
71GABAergic synapse_Homo sapiens_hsa047270.88664169
72Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.88495561
73Small cell lung cancer_Homo sapiens_hsa052220.88481320
74Inositol phosphate metabolism_Homo sapiens_hsa005620.87806999
75Prostate cancer_Homo sapiens_hsa052150.87507101
76Toll-like receptor signaling pathway_Homo sapiens_hsa046200.86810374
77Amphetamine addiction_Homo sapiens_hsa050310.85119809
78FoxO signaling pathway_Homo sapiens_hsa040680.84550592
79Fatty acid biosynthesis_Homo sapiens_hsa000610.83839760
80Basal transcription factors_Homo sapiens_hsa030220.83621540
81Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.83481367
82Steroid biosynthesis_Homo sapiens_hsa001000.83278719
83NF-kappa B signaling pathway_Homo sapiens_hsa040640.81624754
84Vascular smooth muscle contraction_Homo sapiens_hsa042700.79779554
85Fat digestion and absorption_Homo sapiens_hsa049750.79697053
86Platelet activation_Homo sapiens_hsa046110.79432953
87Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.79163877
88Glutamatergic synapse_Homo sapiens_hsa047240.78926853
89mTOR signaling pathway_Homo sapiens_hsa041500.78422590
90Glucagon signaling pathway_Homo sapiens_hsa049220.77722085
91Proteoglycans in cancer_Homo sapiens_hsa052050.76276600
92Synaptic vesicle cycle_Homo sapiens_hsa047210.75084278
93NOD-like receptor signaling pathway_Homo sapiens_hsa046210.75018586
94Focal adhesion_Homo sapiens_hsa045100.74422175
95cGMP-PKG signaling pathway_Homo sapiens_hsa040220.72169706
96MicroRNAs in cancer_Homo sapiens_hsa052060.70707785
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70187377
98Adipocytokine signaling pathway_Homo sapiens_hsa049200.69044396
99Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68594582
100Malaria_Homo sapiens_hsa051440.68400279
101Toxoplasmosis_Homo sapiens_hsa051450.67980980
102Pancreatic secretion_Homo sapiens_hsa049720.67346662
103Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.67044698
104Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.63796826
105Prolactin signaling pathway_Homo sapiens_hsa049170.63374040
106Dilated cardiomyopathy_Homo sapiens_hsa054140.63365489
107Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63249058
108RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.62808100
109Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62446203
110Hepatitis C_Homo sapiens_hsa051600.61913809
111Bladder cancer_Homo sapiens_hsa052190.61845851
112Pancreatic cancer_Homo sapiens_hsa052120.60825586
113Phosphatidylinositol signaling system_Homo sapiens_hsa040700.59671817
114Drug metabolism - other enzymes_Homo sapiens_hsa009830.59640283
115Type II diabetes mellitus_Homo sapiens_hsa049300.58993005
116Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58674706
117Linoleic acid metabolism_Homo sapiens_hsa005910.58526743
118Fatty acid elongation_Homo sapiens_hsa000620.55889291
119Circadian rhythm_Homo sapiens_hsa047100.55566785
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.55451282
121Chronic myeloid leukemia_Homo sapiens_hsa052200.55300511
122Salivary secretion_Homo sapiens_hsa049700.54802288
123Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.54799327
124Vibrio cholerae infection_Homo sapiens_hsa051100.54464744
125cAMP signaling pathway_Homo sapiens_hsa040240.53389334
126Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.52751638
127Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.52687254
128Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52360781
129AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.50704653
130alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.50634918
131Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.50446296
132Glycerophospholipid metabolism_Homo sapiens_hsa005640.49552403
133Glutathione metabolism_Homo sapiens_hsa004800.49486978
134Thyroid hormone synthesis_Homo sapiens_hsa049180.49406759
135Glycerolipid metabolism_Homo sapiens_hsa005610.48760239
136Protein digestion and absorption_Homo sapiens_hsa049740.47635972
137Melanoma_Homo sapiens_hsa052180.47454491
138Morphine addiction_Homo sapiens_hsa050320.46607622
139Leishmaniasis_Homo sapiens_hsa051400.46596045
140Influenza A_Homo sapiens_hsa051640.46493682
141Lysosome_Homo sapiens_hsa041420.44735824
142Olfactory transduction_Homo sapiens_hsa047400.44722690
143Leukocyte transendothelial migration_Homo sapiens_hsa046700.44224820
144AMPK signaling pathway_Homo sapiens_hsa041520.43456995
145Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.43255555
146Viral myocarditis_Homo sapiens_hsa054160.43243467
147Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.42791254
148Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42590070
149One carbon pool by folate_Homo sapiens_hsa006700.42379185
150Oxidative phosphorylation_Homo sapiens_hsa001900.41814525
151Graft-versus-host disease_Homo sapiens_hsa053320.40825129
152Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.40690467
153Taste transduction_Homo sapiens_hsa047420.40152158
154Ovarian steroidogenesis_Homo sapiens_hsa049130.39823769
155Oocyte meiosis_Homo sapiens_hsa041140.39439384
156N-Glycan biosynthesis_Homo sapiens_hsa005100.39400531
157Tight junction_Homo sapiens_hsa045300.38878361
158Dorso-ventral axis formation_Homo sapiens_hsa043200.38340187
159RNA degradation_Homo sapiens_hsa030180.37708605
160Osteoclast differentiation_Homo sapiens_hsa043800.37349574
161Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.37140954
162Other glycan degradation_Homo sapiens_hsa005110.36947582
163Endometrial cancer_Homo sapiens_hsa052130.36332136
164Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36085661
165Pertussis_Homo sapiens_hsa051330.34598700
166Calcium signaling pathway_Homo sapiens_hsa040200.34081135
167Long-term potentiation_Homo sapiens_hsa047200.32786661
168Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.32611677
169Oxytocin signaling pathway_Homo sapiens_hsa049210.30465061

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