MMRN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein belonging to the member of elastin microfibril interface-located (EMILIN) protein family. This family member is an extracellular matrix glycoprotein that can interfere with tumor angiogenesis and growth. It serves as a transforming growth factor beta antagonist and can interfere with the VEGF-A/VEGFR2 pathway. A related pseudogene has been identified on chromosome 6. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vascular endothelial growth factor signaling pathway (GO:0038084)8.66536439
2endothelium development (GO:0003158)8.04902132
3lymphangiogenesis (GO:0001946)7.09583240
4cellular response to vascular endothelial growth factor stimulus (GO:0035924)6.98441852
5retina vasculature morphogenesis in camera-type eye (GO:0061299)6.29883012
6positive regulation of vasculogenesis (GO:2001214)5.97097008
7ovulation from ovarian follicle (GO:0001542)5.55427296
8surfactant homeostasis (GO:0043129)5.30293021
9vascular endothelial growth factor receptor signaling pathway (GO:0048010)5.27093191
10transcytosis (GO:0045056)5.18839961
11blood vessel maturation (GO:0001955)4.95451469
12endothelial tube morphogenesis (GO:0061154)4.92065154
13morphogenesis of an endothelium (GO:0003159)4.92065154
14regulation of vasculogenesis (GO:2001212)4.86405178
15glomerular filtration (GO:0003094)4.84338512
16wound healing, spreading of epidermal cells (GO:0035313)4.79331334
17regulation of endothelial cell differentiation (GO:0045601)4.79159769
18* negative regulation of blood vessel endothelial cell migration (GO:0043537)4.70350661
19heart trabecula formation (GO:0060347)4.68688345
20endothelial cell morphogenesis (GO:0001886)4.60891640
21blood vessel endothelial cell migration (GO:0043534)4.59659488
22cell migration involved in sprouting angiogenesis (GO:0002042)4.55394707
23renal filtration (GO:0097205)4.54280874
24endothelial cell differentiation (GO:0045446)4.41375930
25basement membrane organization (GO:0071711)4.39914397
26patterning of blood vessels (GO:0001569)4.29943459
27venous blood vessel morphogenesis (GO:0048845)4.25082917
28sprouting angiogenesis (GO:0002040)4.24480375
29chemical homeostasis within a tissue (GO:0048875)4.11692155
30negative regulation of adherens junction organization (GO:1903392)3.89448521
31negative regulation of focal adhesion assembly (GO:0051895)3.89448521
32negative regulation of cell junction assembly (GO:1901889)3.89448521
33peptidyl-tyrosine autophosphorylation (GO:0038083)3.86236646
34artery development (GO:0060840)3.81400848
35vasculogenesis (GO:0001570)3.74781705
36positive regulation of urine volume (GO:0035810)3.69638867
37negative regulation of platelet activation (GO:0010544)3.57406198
38negative regulation of endothelial cell apoptotic process (GO:2000352)3.57310275
39embryonic heart tube development (GO:0035050)3.51986725
40bundle of His cell to Purkinje myocyte communication (GO:0086069)3.49897897
41positive regulation of protein kinase C signaling (GO:0090037)3.42255850
42negative regulation of nitric-oxide synthase activity (GO:0051001)3.38156844
43ventricular trabecula myocardium morphogenesis (GO:0003222)3.38118039
44endothelial cell chemotaxis (GO:0035767)3.36878489
45endothelial cell migration (GO:0043542)3.33022078
46fatty acid transmembrane transport (GO:1902001)3.30756707
47cardiac myofibril assembly (GO:0055003)3.28930507
48* regulation of cell migration involved in sprouting angiogenesis (GO:0090049)3.27843957
49positive regulation of odontogenesis (GO:0042482)3.27831750
50establishment of endothelial barrier (GO:0061028)3.27126385
51arginine catabolic process (GO:0006527)3.21837727
52trabecula morphogenesis (GO:0061383)3.18241828
53* regulation of blood vessel endothelial cell migration (GO:0043535)3.17950684
54cell migration involved in heart development (GO:0060973)3.17423478
55heart trabecula morphogenesis (GO:0061384)3.13497089
56positive regulation of focal adhesion assembly (GO:0051894)3.13105110
57positive regulation of cell junction assembly (GO:1901890)3.13105110
58coronary vasculature morphogenesis (GO:0060977)3.05849283
59negative regulation of DNA biosynthetic process (GO:2000279)3.05724523
60negative regulation of Rho protein signal transduction (GO:0035024)3.02977751
61trabecula formation (GO:0060343)3.02577147
62interleukin-6-mediated signaling pathway (GO:0070102)3.02162890
63neuron remodeling (GO:0016322)3.00906922
64semaphorin-plexin signaling pathway (GO:0071526)3.00888716
65low-density lipoprotein particle clearance (GO:0034383)3.00260683
66ovulation (GO:0030728)2.99126217
67glomerular basement membrane development (GO:0032836)2.98960519
68phagocytosis, recognition (GO:0006910)2.98828415
69regulation of establishment or maintenance of cell polarity (GO:0032878)2.98765187
70regulation of endothelial cell apoptotic process (GO:2000351)2.93914526
71leukocyte tethering or rolling (GO:0050901)2.93711193
72positive regulation of endothelial cell migration (GO:0010595)2.93142313
73substrate-dependent cell migration (GO:0006929)2.92969153
74positive regulation of endothelial cell differentiation (GO:0045603)2.92677745
75ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.92125760
76plasma membrane repair (GO:0001778)2.91758437
77ganglion development (GO:0061548)2.91730867
78positive regulation of receptor recycling (GO:0001921)2.91508736
79positive regulation of endothelial cell proliferation (GO:0001938)2.91313664
80wound healing, spreading of cells (GO:0044319)2.91018879
81Notch signaling involved in heart development (GO:0061314)2.89839390
82negative regulation of protein autophosphorylation (GO:0031953)2.89489031
83positive regulation of adherens junction organization (GO:1903393)2.87898432
84hyaluronan catabolic process (GO:0030214)2.87774657
85endocrine hormone secretion (GO:0060986)2.87766901
86adhesion of symbiont to host (GO:0044406)2.87106763
87regulation of sequestering of triglyceride (GO:0010889)2.87042729
88negative regulation of endothelial cell proliferation (GO:0001937)2.86784179
89* negative regulation of angiogenesis (GO:0016525)2.86078857
90regulation of actin filament-based movement (GO:1903115)2.85418932
91regulation of vascular permeability (GO:0043114)2.85185677
92regulation of cholesterol storage (GO:0010885)2.83964088
93regulation of cell-substrate junction assembly (GO:0090109)2.83823743
94regulation of focal adhesion assembly (GO:0051893)2.83823743
95angiogenesis involved in wound healing (GO:0060055)2.82537743
96* negative regulation of epithelial cell migration (GO:0010633)2.82518050
97* regulation of endothelial cell migration (GO:0010594)2.82276605
98positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)2.81824529
99* negative regulation of endothelial cell migration (GO:0010596)2.81303104
100sarcomere organization (GO:0045214)2.81163006
101regulation of adherens junction organization (GO:1903391)2.78310807
102blood vessel remodeling (GO:0001974)2.78164095
103myofibril assembly (GO:0030239)2.77491262
104cAMP biosynthetic process (GO:0006171)2.76680654
105regulation of endothelial cell proliferation (GO:0001936)2.75876223
106carnitine shuttle (GO:0006853)2.75624071
107neuron projection extension involved in neuron projection guidance (GO:1902284)2.75399391
108axon extension involved in axon guidance (GO:0048846)2.75399391
109* negative regulation of blood vessel morphogenesis (GO:2000181)2.74478629
110gap junction assembly (GO:0016264)2.72357470
111regulation of sarcomere organization (GO:0060297)2.71650116
112* regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)2.70987727
113nephron epithelium development (GO:0072009)2.70509035
114protein kinase C signaling (GO:0070528)2.69026056
115positive regulation of glomerulus development (GO:0090193)2.68629520
116regulation of urine volume (GO:0035809)2.68150616
117metanephric nephron epithelium development (GO:0072243)2.67732749
118positive regulation of endothelial cell apoptotic process (GO:2000353)2.66147112
119endothelial cell proliferation (GO:0001935)2.65614548
120cardiac muscle cell proliferation (GO:0060038)2.65285230
121blood vessel morphogenesis (GO:0048514)2.65114439
122cardiac muscle tissue morphogenesis (GO:0055008)2.63584994
123potassium ion import (GO:0010107)2.61883777
124* angiogenesis (GO:0001525)2.60803935
125regulation of p38MAPK cascade (GO:1900744)2.60606421
126brown fat cell differentiation (GO:0050873)2.60305529
127metanephric epithelium development (GO:0072207)2.59019579
128* negative regulation of vasculature development (GO:1901343)2.58271942
129glomerular visceral epithelial cell development (GO:0072015)2.58054621
130negative regulation of cell-matrix adhesion (GO:0001953)2.57794566
131mRNA transcription from RNA polymerase II promoter (GO:0042789)2.57767597
132Notch receptor processing (GO:0007220)2.57625414
133negative regulation of blood coagulation (GO:0030195)2.57536769
134regulation of glomerular filtration (GO:0003093)2.56740218
135anatomical structure maturation (GO:0071695)2.54947437
136negative regulation of cell-substrate adhesion (GO:0010812)2.54802272
137positive regulation of epithelial cell migration (GO:0010634)2.53328030
138* regulation of epithelial cell migration (GO:0010632)2.52470968
139lymph vessel development (GO:0001945)10.2554056

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.38737092
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.16679992
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.63094759
4GATA2_21666600_ChIP-Seq_HMVEC_Human3.58087211
5TRIM28_21343339_ChIP-Seq_HEK293_Human3.30731072
6CLOCK_20551151_ChIP-Seq_293T_Human3.18746168
7TP63_17297297_ChIP-ChIP_HaCaT_Human3.04797071
8KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.99246838
9KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.99246838
10KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.99246838
11STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.80441071
12RXR_22158963_ChIP-Seq_LIVER_Mouse2.66284229
13LXR_22158963_ChIP-Seq_LIVER_Mouse2.51221505
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.46320640
15FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.35778204
16EP300_21415370_ChIP-Seq_HL-1_Mouse2.35622153
17PPARA_22158963_ChIP-Seq_LIVER_Mouse2.30506535
18TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.09826224
19* ELK3_25401928_ChIP-Seq_HUVEC_Human2.09274200
20ESR1_21235772_ChIP-Seq_MCF-7_Human2.00937035
21* TBX20_22328084_ChIP-Seq_HEART_Mouse1.98318462
22* TBX20_22080862_ChIP-Seq_HEART_Mouse1.98318462
23NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.96628615
24STAT6_21828071_ChIP-Seq_BEAS2B_Human1.95783446
25ESR2_21235772_ChIP-Seq_MCF-7_Human1.94328025
26* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92639249
27NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.92296041
28ZNF263_19887448_ChIP-Seq_K562_Human1.89272330
29ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.83112266
30TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.79339287
31NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.78019690
32SALL4_18804426_ChIP-ChIP_XEN_Mouse1.72515759
33KDM2B_26808549_Chip-Seq_SUP-B15_Human1.68355146
34EZH2_18974828_ChIP-Seq_MESCs_Mouse1.67999647
35RNF2_18974828_ChIP-Seq_MESCs_Mouse1.67999647
36EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.67862058
37PPAR_26484153_Chip-Seq_NCI-H1993_Human1.61490334
38GATA1_22025678_ChIP-Seq_K562_Human1.59025725
39HIF1A_21447827_ChIP-Seq_MCF-7_Human1.56656769
40SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.56518355
41CDX2_20551321_ChIP-Seq_CACO-2_Human1.55483371
42GATA1_19941826_ChIP-Seq_K562_Human1.55227843
43ESR1_20079471_ChIP-ChIP_T-47D_Human1.53909256
44GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.49044649
45SMAD_19615063_ChIP-ChIP_OVARY_Human1.45414655
46SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.45235563
47WT1_19549856_ChIP-ChIP_CCG9911_Human1.44014972
48SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.39594874
49PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.37653552
50SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.34408096
51TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.33869077
52MTF2_20144788_ChIP-Seq_MESCs_Mouse1.31874321
53BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.30791560
54* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.27563760
55CDX2_19796622_ChIP-Seq_MESCs_Mouse1.26438610
56CJUN_26792858_Chip-Seq_BT549_Human1.25476153
57NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.23039224
58* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.20791188
59POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.20649352
60MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.20488814
61CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.18575180
62SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.17413564
63FOXO3_23340844_ChIP-Seq_DLD1_Human1.14809575
64RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.14519299
65RXR_22108803_ChIP-Seq_LS180_Human1.13757433
66NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.12263471
67TCF3_18692474_ChIP-Seq_MEFs_Mouse1.11314138
68SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.09735712
69STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.09425067
70ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07655027
71ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.07534341
72BRD4_25478319_ChIP-Seq_HGPS_Human1.06922397
73DROSHA_22980978_ChIP-Seq_HELA_Human1.06894814
74STAT3_1855785_ChIP-Seq_MESCs_Mouse1.06629374
75IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.06539520
76EGR1_23403033_ChIP-Seq_LIVER_Mouse1.05775157
77ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04834906
78SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.02230632
79* SOX2_20726797_ChIP-Seq_SW620_Human1.01888027
80NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.01153406
81ARNT_22903824_ChIP-Seq_MCF-7_Human0.99999949
82JARID2_20075857_ChIP-Seq_MESCs_Mouse0.99871612
83NR3C1_23031785_ChIP-Seq_PC12_Mouse0.99454735
84WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.99048987
85VDR_22108803_ChIP-Seq_LS180_Human0.97124232
86NFIB_24661679_ChIP-Seq_LUNG_Mouse0.96762533
87RACK7_27058665_Chip-Seq_MCF-7_Human0.96469117
88CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.96440057
89RNF2_27304074_Chip-Seq_ESCs_Mouse0.96041825
90LXR_22292898_ChIP-Seq_THP-1_Human0.95824487
91FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.95509570
92NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.95300996
93RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.93680307
94EZH2_27294783_Chip-Seq_ESCs_Mouse0.93412671
95PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.91671168
96KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.91666469
97TCF4_18268006_ChIP-ChIP_LS174T_Human0.91641604
98SOX9_24532713_ChIP-Seq_HFSC_Mouse0.91526462
99KDM2B_26808549_Chip-Seq_K562_Human0.90451151
100BCAT_22108803_ChIP-Seq_LS180_Human0.89674592
101SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.89671649
102* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.89324643
103* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.89324643
104SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.89232279
105JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88893339
106PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.88792736
107CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.87962637
108JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85742878
109EED_16625203_ChIP-ChIP_MESCs_Mouse0.85158915
110FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.84589016
111GATA2_19941826_ChIP-Seq_K562_Human0.83357275
112* TP53_23651856_ChIP-Seq_MEFs_Mouse0.83156264
113SOX2_18555785_ChIP-Seq_MESCs_Mouse0.82860171
114PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.82838661
115ISL1_27105846_Chip-Seq_CPCs_Mouse0.82714745
116TP63_23658742_ChIP-Seq_EP156T_Human0.82274396
117PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.81850516
118PIAS1_25552417_ChIP-Seq_VCAP_Human0.81826528
119RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.80846560
120P63_26484246_Chip-Seq_KERATINOCYTES_Human0.80779714
121STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.79932360
122AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.79820759
123AHR_22903824_ChIP-Seq_MCF-7_Human0.78840789
124MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.77572609
125FOXA2_19822575_ChIP-Seq_HepG2_Human0.77028853
126SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.76407294
127PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.76196845
128ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.75754150
129RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.74037002
130SMC1_22415368_ChIP-Seq_MEFs_Mouse0.73891888
131CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.73798578
132SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.73645825
133SMC3_22415368_ChIP-Seq_MEFs_Mouse0.72289849
134SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71261066
135SMAD3_21741376_ChIP-Seq_HESCs_Human0.70942642
136SCL_19346495_ChIP-Seq_HPC-7_Human0.70571910
137NRF2_20460467_ChIP-Seq_MEFs_Mouse0.70284701

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system7.57781876
2MP0001879_abnormal_lymphatic_vessel5.88344658
3MP0005167_abnormal_blood-brain_barrier4.59364407
4MP0003724_increased_susceptibility_to4.25644707
5MP0004272_abnormal_basement_membrane4.12909459
6MP0004084_abnormal_cardiac_muscle3.54477544
7MP0003828_pulmonary_edema3.28401895
8MP0004215_abnormal_myocardial_fiber3.13093032
9MP0006054_spinal_hemorrhage3.07638889
10MP0000013_abnormal_adipose_tissue2.35936982
11MP0004036_abnormal_muscle_relaxation2.22686882
12MP0005670_abnormal_white_adipose2.10086743
13MP0005330_cardiomyopathy1.99750505
14MP0006138_congestive_heart_failure1.99059113
15MP0000751_myopathy1.95153393
16MP0002837_dystrophic_cardiac_calcinosis1.89156188
17MP0004130_abnormal_muscle_cell1.88329211
18MP0008775_abnormal_heart_ventricle1.87395745
19MP0008004_abnormal_stomach_pH1.76062332
20MP0000767_abnormal_smooth_muscle1.72486361
21MP0002127_abnormal_cardiovascular_syste1.71711120
22MP0002332_abnormal_exercise_endurance1.66424996
23MP0005165_increased_susceptibility_to1.66250643
24MP0005385_cardiovascular_system_phenoty1.64081356
25MP0001544_abnormal_cardiovascular_syste1.64081356
26MP0003279_aneurysm1.60006980
27MP0002933_joint_inflammation1.59369298
28MP0004484_altered_response_of1.57119889
29MP0000343_altered_response_to1.56838612
30MP0010630_abnormal_cardiac_muscle1.55389674
31MP0002972_abnormal_cardiac_muscle1.53415339
32MP0002138_abnormal_hepatobiliary_system1.52798191
33MP0009780_abnormal_chondrocyte_physiolo1.51996961
34MP0005275_abnormal_skin_tensile1.49667885
35MP0004147_increased_porphyrin_level1.49034157
36MP0000750_abnormal_muscle_regeneration1.40495267
37MP0003300_gastrointestinal_ulcer1.39797139
38MP0005595_abnormal_vascular_smooth1.34687879
39MP0005620_abnormal_muscle_contractility1.33538240
40MP0010030_abnormal_orbit_morphology1.33127374
41MP0000249_abnormal_blood_vessel1.32993595
42MP0004085_abnormal_heartbeat1.32608460
43MP0005360_urolithiasis1.31757594
44MP0005623_abnormal_meninges_morphology1.28720200
45MP0000749_muscle_degeneration1.28555292
46MP0002128_abnormal_blood_circulation1.28290639
47MP0003646_muscle_fatigue1.26645126
48MP0005085_abnormal_gallbladder_physiolo1.25123957
49MP0005084_abnormal_gallbladder_morpholo1.22388649
50MP0001851_eye_inflammation1.21117252
51MP0003705_abnormal_hypodermis_morpholog1.20816154
52MP0002925_abnormal_cardiovascular_devel1.20368590
53MP0004087_abnormal_muscle_fiber1.17537825
54MP0005666_abnormal_adipose_tissue1.17098309
55MP0003191_abnormal_cellular_cholesterol1.16903430
56MP0009278_abnormal_bone_marrow1.14309280
57MP0001614_abnormal_blood_vessel1.12470667
58MP0003566_abnormal_cell_adhesion1.11827089
59MP0000003_abnormal_adipose_tissue1.09850574
60MP0009697_abnormal_copulation1.05926971
61MP0005375_adipose_tissue_phenotype1.03590475
62MP0004233_abnormal_muscle_weight1.01825504
63MP0002295_abnormal_pulmonary_circulatio1.01651723
64MP0000266_abnormal_heart_morphology1.01086685
65MP0003868_abnormal_feces_composition0.97325348
66MP0003303_peritoneal_inflammation0.97023940
67MP0000230_abnormal_systemic_arterial0.95904350
68MP0005409_darkened_coat_color0.93165053
69MP0005365_abnormal_bile_salt0.92810174
70MP0003137_abnormal_impulse_conducting0.92502581
71MP0010329_abnormal_lipoprotein_level0.92004974
72MP0001915_intracranial_hemorrhage0.91687585
73MP0008438_abnormal_cutaneous_collagen0.91181097
74MP0002877_abnormal_melanocyte_morpholog0.90732390
75MP0005164_abnormal_response_to0.89755685
76MP0003941_abnormal_skin_development0.89547929
77MP0004883_abnormal_blood_vessel0.89335311
78MP0000465_gastrointestinal_hemorrhage0.87737989
79MP0005503_abnormal_tendon_morphology0.87021404
80MP0003045_fibrosis0.86073992
81MP0002971_abnormal_brown_adipose0.83910102
82MP0001849_ear_inflammation0.82694304
83MP0005083_abnormal_biliary_tract0.81861166
84MP0009379_abnormal_foot_pigmentation0.81840879
85MP0002106_abnormal_muscle_physiology0.80017906
86MP0001661_extended_life_span0.79637061
87MP0000747_muscle_weakness0.79194136
88MP0001784_abnormal_fluid_regulation0.78578946
89MP0001958_emphysema0.77059493
90MP0005319_abnormal_enzyme/_coenzyme0.73846277
91MP0003950_abnormal_plasma_membrane0.72236084
92MP0010352_gastrointestinal_tract_polyps0.71534385
93MP0002638_abnormal_pupillary_reflex0.71497250
94MP0002139_abnormal_hepatobiliary_system0.71319100
95MP0003252_abnormal_bile_duct0.70129321
96MP0004185_abnormal_adipocyte_glucose0.69471922
97MP0010234_abnormal_vibrissa_follicle0.69408181
98MP0002168_other_aberrant_phenotype0.68038708
99MP0002896_abnormal_bone_mineralization0.67786160
100MP0003943_abnormal_hepatobiliary_system0.67738128
101MP0002796_impaired_skin_barrier0.67008095
102MP0005369_muscle_phenotype0.66515674
103MP0000467_abnormal_esophagus_morphology0.65460975
104MP0005187_abnormal_penis_morphology0.65255186
105MP0003567_abnormal_fetal_cardiomyocyte0.64657890
106MP0000609_abnormal_liver_physiology0.63880420
107MP0002088_abnormal_embryonic_growth/wei0.62914162
108MP0005023_abnormal_wound_healing0.61892645
109MP0000733_abnormal_muscle_development0.61708218
110MP0003091_abnormal_cell_migration0.61186876
111MP0004145_abnormal_muscle_electrophysio0.61106776
112MP0002086_abnormal_extraembryonic_tissu0.60164981
113MP0009643_abnormal_urine_homeostasis0.59826200
114MP0003984_embryonic_growth_retardation0.59566677
115MP0009764_decreased_sensitivity_to0.58078542
116MP0000759_abnormal_skeletal_muscle0.56188684
117MP0003948_abnormal_gas_homeostasis0.55194702
118MP0004782_abnormal_surfactant_physiolog0.55010323
119MP0003385_abnormal_body_wall0.53486308
120MP0002133_abnormal_respiratory_system0.53173060
121MP0005388_respiratory_system_phenotype0.53173060
122MP0002108_abnormal_muscle_morphology0.52540491
123MP0001727_abnormal_embryo_implantation0.51022725
124MP0005397_hematopoietic_system_phenotyp0.50296488
125MP0001545_abnormal_hematopoietic_system0.50296488
126MP0002269_muscular_atrophy0.49890095
127MP0000516_abnormal_urinary_system0.48659556
128MP0005367_renal/urinary_system_phenotyp0.48659556
129MP0000537_abnormal_urethra_morphology0.48609103

Predicted human phenotypes

RankGene SetZ-score
1Polycythemia (HP:0001901)5.72295870
2Nonimmune hydrops fetalis (HP:0001790)5.40420426
3Ventricular tachycardia (HP:0004756)5.21682207
4Spontaneous hematomas (HP:0007420)4.94397687
5Hematochezia (HP:0002573)4.56716428
6Arterial tortuosity (HP:0005116)4.54833293
7Muscle fiber splitting (HP:0003555)4.48762505
8Esophageal varix (HP:0002040)4.48335326
9Protrusio acetabuli (HP:0003179)4.45126801
10Wrist flexion contracture (HP:0001239)4.27086736
11Vascular tortuosity (HP:0004948)4.24653931
12Broad metatarsal (HP:0001783)4.21311061
13Sudden death (HP:0001699)4.20488314
14Increased connective tissue (HP:0009025)4.13436727
15Atrial fibrillation (HP:0005110)3.88532103
16Lymphangioma (HP:0100764)3.87362644
17Supraventricular arrhythmia (HP:0005115)3.70987991
18Deep venous thrombosis (HP:0002625)3.66726747
19Spinal rigidity (HP:0003306)3.62304917
20Capillary hemangiomas (HP:0005306)3.57270047
21Primary atrial arrhythmia (HP:0001692)3.55633043
22Lipoatrophy (HP:0100578)3.51723248
23Hyporeflexia of lower limbs (HP:0002600)3.42280188
24Supraventricular tachycardia (HP:0004755)3.42094239
25Cerebral aneurysm (HP:0004944)3.40046320
26Abnormality of the nasal mucosa (HP:0000433)3.36947585
27Cerebral hemorrhage (HP:0001342)3.33494474
28Difficulty running (HP:0009046)3.23159596
29Congenital, generalized hypertrichosis (HP:0004540)3.19092821
30Right ventricular cardiomyopathy (HP:0011663)3.13703716
31Short hallux (HP:0010109)3.12489332
32Hemorrhage of the eye (HP:0011885)3.03770477
33Joint hemorrhage (HP:0005261)3.02739229
34Hypoglycemic coma (HP:0001325)3.02235734
35Conjunctival telangiectasia (HP:0000524)3.00568479
36Absent hand (HP:0004050)2.92786515
37Visceral angiomatosis (HP:0100761)2.90599176
38Aplasia/Hypoplasia of the hallux (HP:0008362)2.89700529
39Hypoplastic ischia (HP:0003175)2.86542837
40Overgrowth (HP:0001548)2.86021258
41Aortic dissection (HP:0002647)2.85656328
42Portal hypertension (HP:0001409)2.80187860
43Mesangial abnormality (HP:0001966)2.75575087
44Exercise-induced muscle cramps (HP:0003710)2.75474175
45Abnormality of the ischium (HP:0003174)2.74234756
46Dilated cardiomyopathy (HP:0001644)2.73624590
47Hemangiomatosis (HP:0007461)2.71645085
48Hypoalphalipoproteinemia (HP:0003233)2.67426759
49Abnormality of the vasculature of the conjunctiva (HP:0008054)2.67312144
50Adactyly (HP:0009776)2.64798094
51Abnormality of the intrinsic pathway (HP:0010989)2.61882180
52Cavernous hemangioma (HP:0001048)2.61286907
53Exercise-induced myalgia (HP:0003738)2.60542978
54Porencephaly (HP:0002132)2.58702711
55Abnormality of the hepatic vasculature (HP:0006707)2.58424723
56Myoglobinuria (HP:0002913)2.57863514
57EMG: myopathic abnormalities (HP:0003458)2.54033793
58Premature rupture of membranes (HP:0001788)2.52306628
59Aneurysm (HP:0002617)2.49329566
60Calf muscle hypertrophy (HP:0008981)2.49062084
61Venous insufficiency (HP:0005293)2.48158818
62Prolonged partial thromboplastin time (HP:0003645)2.46787833
63Atrioventricular block (HP:0001678)2.44689206
64Aortic valve stenosis (HP:0001650)2.42963240
65Increased variability in muscle fiber diameter (HP:0003557)2.42302230
66Lymphedema (HP:0001004)2.38718894
67Hip contracture (HP:0003273)2.38448695
68Difficulty climbing stairs (HP:0003551)2.35496341
69Myocardial infarction (HP:0001658)2.33320963
70Syncope (HP:0001279)2.31254499
71Neonatal death (HP:0003811)2.31000162
72Venous abnormality (HP:0002624)2.30466259
73Large for gestational age (HP:0001520)2.30236912
74Myotonia (HP:0002486)2.30205550
75Skull defect (HP:0001362)2.28946496
76Pulmonary artery stenosis (HP:0004415)2.27397052
77Abnormality of skeletal muscle fiber size (HP:0012084)2.26806716
78Areflexia of lower limbs (HP:0002522)2.26772349
79Subcapsular cataract (HP:0000523)2.26569619
80Ketoacidosis (HP:0001993)2.25565689
81Limited hip movement (HP:0008800)2.22904438
82Absent toe (HP:0010760)2.22821743
83Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.22715122
84Pulmonary hypertension (HP:0002092)2.21246400
85Pigmentary retinal degeneration (HP:0001146)2.21095056
86Facial diplegia (HP:0001349)2.18184921
87Hemiplegia (HP:0002301)2.16574743
88Muscle hypertrophy of the lower extremities (HP:0008968)2.16007768
89Microcytic anemia (HP:0001935)2.15733295
90Abnormality of the calf musculature (HP:0001430)2.14611735
91Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.13750238
92Vertebral clefting (HP:0008428)2.13746100
93Muscle fiber inclusion bodies (HP:0100299)2.12865332
94Hyperglycinuria (HP:0003108)2.12346184
95Ectopia lentis (HP:0001083)2.11937595
96Chondrocalcinosis (HP:0000934)2.11278993
97Abnormal vertebral ossification (HP:0100569)2.10815288
98Cardiovascular calcification (HP:0011915)2.10593857
99Menorrhagia (HP:0000132)2.10108770
100Shallow orbits (HP:0000586)2.09468281
101Wormian bones (HP:0002645)2.09322038
102Acanthosis nigricans (HP:0000956)2.09232648
103Prolonged QT interval (HP:0001657)2.09051887
104Stroke (HP:0001297)2.08668294
105Bundle branch block (HP:0011710)2.08281409
106Vascular calcification (HP:0004934)2.07562586
107Hyperinsulinemic hypoglycemia (HP:0000825)2.06961223
108Heart block (HP:0012722)2.06930970
109Rhabdomyolysis (HP:0003201)2.06720739
110Pancreatic islet-cell hyperplasia (HP:0004510)2.06454203
111Palpitations (HP:0001962)2.05734541
112Nemaline bodies (HP:0003798)2.04681443
113Testicular atrophy (HP:0000029)2.04323822
114Asymmetric septal hypertrophy (HP:0001670)2.03881503
115Hypoplasia of the iris (HP:0007676)2.03094418
116Tetraparesis (HP:0002273)2.02885786
117Abnormality of Sharpey fibers (HP:0100685)2.02338873
118Distal lower limb muscle weakness (HP:0009053)2.01999729
119Prominent supraorbital ridges (HP:0000336)2.01643422
120Large hands (HP:0001176)2.01323368
121Hyperammonemia (HP:0001987)2.00968441
122Abnormal atrioventricular conduction (HP:0005150)2.00012317
123Aortic aneurysm (HP:0004942)1.99331064
124Mitral valve prolapse (HP:0001634)1.98960701
125Dicarboxylic aciduria (HP:0003215)1.98702756
126Abnormality of dicarboxylic acid metabolism (HP:0010995)1.98702756
127Centrally nucleated skeletal muscle fibers (HP:0003687)1.98213816
128Muscle stiffness (HP:0003552)1.98176122
129Cervical subluxation (HP:0003308)1.97206167
130Type 1 muscle fiber predominance (HP:0003803)1.97176876
131Abnormality of fatty-acid metabolism (HP:0004359)1.96042736
132Distal lower limb amyotrophy (HP:0008944)1.93329737
133Polar cataract (HP:0010696)1.92431435
134High pitched voice (HP:0001620)1.92208213
135Distal arthrogryposis (HP:0005684)1.91586792
136Mucosal telangiectasiae (HP:0100579)1.89916568
137Round ear (HP:0100830)1.89680218
138Striae distensae (HP:0001065)1.88830461
139Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.87995035
140Short 4th metacarpal (HP:0010044)1.87995035
141Flexion contracture of toe (HP:0005830)1.87001249
142Joint contractures involving the joints of the feet (HP:0100492)1.87001249
143Complement deficiency (HP:0004431)1.86793581
144Neck muscle weakness (HP:0000467)1.86536009
145Oligomenorrhea (HP:0000876)1.84905706

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR9.26554497
2TGFBR24.11357523
3TGFBR12.77976063
4RIPK12.10924746
5TIE110.1651991
6MYLK1.70590592
7EPHB21.63895668
8PTK2B1.62288841
9ERN11.60812792
10GRK11.57755797
11PDK21.52496989
12TTN1.44359936
13INSRR1.35595626
14NTRK11.34395941
15PRKG21.17999836
16MAP2K31.17914262
17EEF2K1.11209362
18BCKDK1.11142507
19DMPK1.10944934
20FER1.07766379
21MAPK121.06487964
22MAP3K30.96895497
23WNK40.93997155
24PKN20.87590148
25PTK60.85409239
26MAPK150.84914984
27OBSCN0.80642052
28PDGFRA0.80343524
29PRKAA20.78398711
30CAMK40.75583121
31FGFR40.75415350
32PRKD10.68877702
33CSK0.68521136
34MAPK70.67489355
35PHKG20.67340985
36PHKG10.67340985
37EPHB10.67127221
38JAK10.66808789
39AKT30.66118683
40EPHA20.61674571
41PAK40.61567780
42NLK0.61422913
43MAP3K60.59326547
44FLT30.58235610
45PDK40.56898464
46PDK30.56898464
47TRIB30.55116693
48LMTK20.54821724
49MOS0.54286113
50MAP3K110.54128882
51SIK10.50786292
52PIK3CG0.50373589
53JAK30.50368325
54JAK20.49847873
55ROCK20.48953158
56RPS6KA20.47892348
57TEC0.46881476
58TESK10.44308915
59GSK3A0.44146300
60EPHA30.44131743
61ZAP700.43921223
62PTK20.43774529
63STK390.43371216
64PRKD20.43071844
65IGF1R0.40354918
66MAP3K130.39711112
67PRKCH0.37983094
68PRKAA10.37311853
69FGFR30.35718304
70KIT0.33937716
71LATS10.33267987
72MARK20.32790735
73MAPK40.30815802
74GRK70.30490472
75PIK3CA0.29372521
76CDK90.29187257
77PDPK10.28965005
78MET0.28622403
79MAP3K10.28486557
80CAMK1D0.27809653
81DDR20.26896415
82MATK0.26520048
83MAP3K70.26225723
84TYK20.26152276
85MAPKAPK30.25583275
86LRRK20.25170878
87EGFR0.25167685
88SGK20.25145487
89HCK0.24694782
90NEK90.23647316
91TBK10.23613937
92PKN10.23343330
93PAK20.23296670
94SGK30.23255072
95PINK10.23145481
96MTOR0.22947118
97SRC0.22921756
98ABL20.22427693
99MAP2K20.21739974
100ILK0.19903616
101TYRO30.19689053
102RET0.19589197
103FRK0.19264488
104STK100.19105061
105MAPKAPK50.18624414
106FES0.18056593
107FGFR20.18016584
108INSR0.16366434
109LATS20.15289116
110PRKCE0.14861095
111TNIK0.14430802
112CAMK10.14375739
113MAP3K140.14371727
114AKT20.13860972
115ADRBK10.13712599
116DAPK30.13702740
117CDC42BPA0.13495718
118PRKD30.13378234
119SGK4940.13273271
120SGK2230.13273271
121ROCK10.12615327
122GRK50.12137089
123PDGFRB0.11659238
124MAP2K10.11544211
125TRPM70.11316874
126PRKACB0.11108831
127MARK30.10796838
128CAMK1G0.10624558
129ITK0.10207811

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan degradation_Homo sapiens_hsa005313.00951890
2Arginine biosynthesis_Homo sapiens_hsa002202.82514067
3Propanoate metabolism_Homo sapiens_hsa006402.69763652
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.69027388
5Fatty acid degradation_Homo sapiens_hsa000712.64575760
6Complement and coagulation cascades_Homo sapiens_hsa046102.63791911
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.59391514
8PPAR signaling pathway_Homo sapiens_hsa033202.31439353
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.24913642
10ECM-receptor interaction_Homo sapiens_hsa045122.22348950
11Dilated cardiomyopathy_Homo sapiens_hsa054142.18510842
12Malaria_Homo sapiens_hsa051442.06042058
13Focal adhesion_Homo sapiens_hsa045101.98217404
14Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.93448764
15Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.92896450
16Fatty acid metabolism_Homo sapiens_hsa012121.85784860
17Bile secretion_Homo sapiens_hsa049761.74320964
18Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.72180442
19Adherens junction_Homo sapiens_hsa045201.70222487
20African trypanosomiasis_Homo sapiens_hsa051431.67464460
21Primary bile acid biosynthesis_Homo sapiens_hsa001201.64238644
22Leukocyte transendothelial migration_Homo sapiens_hsa046701.59794010
23AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.59681521
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.59662871
25Tryptophan metabolism_Homo sapiens_hsa003801.59313439
26Nitrogen metabolism_Homo sapiens_hsa009101.49244894
27Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.48777100
28Cyanoamino acid metabolism_Homo sapiens_hsa004601.45826276
29Staphylococcus aureus infection_Homo sapiens_hsa051501.35889230
30Notch signaling pathway_Homo sapiens_hsa043301.33632521
31ABC transporters_Homo sapiens_hsa020101.30096417
32Dorso-ventral axis formation_Homo sapiens_hsa043201.26611222
33Caffeine metabolism_Homo sapiens_hsa002321.25969482
34Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.23946885
35Rap1 signaling pathway_Homo sapiens_hsa040151.23706789
36Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.17433255
37Insulin resistance_Homo sapiens_hsa049311.16694563
38Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.14045415
39PI3K-Akt signaling pathway_Homo sapiens_hsa041511.13630141
40Small cell lung cancer_Homo sapiens_hsa052221.11669044
41Fat digestion and absorption_Homo sapiens_hsa049751.11335601
42beta-Alanine metabolism_Homo sapiens_hsa004101.08953758
43Vitamin digestion and absorption_Homo sapiens_hsa049771.08304379
44Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.07527983
45Carbon metabolism_Homo sapiens_hsa012001.06924933
46Adipocytokine signaling pathway_Homo sapiens_hsa049201.06224012
47Phospholipase D signaling pathway_Homo sapiens_hsa040721.04565477
48Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.04481157
49Cardiac muscle contraction_Homo sapiens_hsa042601.01351945
50Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.00420954
51Arginine and proline metabolism_Homo sapiens_hsa003301.00083400
52Pyruvate metabolism_Homo sapiens_hsa006200.99966179
53Starch and sucrose metabolism_Homo sapiens_hsa005000.95568380
54Viral myocarditis_Homo sapiens_hsa054160.93592459
55Peroxisome_Homo sapiens_hsa041460.92680602
56Protein digestion and absorption_Homo sapiens_hsa049740.92254620
57Prion diseases_Homo sapiens_hsa050200.92115166
58Pentose and glucuronate interconversions_Homo sapiens_hsa000400.90057034
59Butanoate metabolism_Homo sapiens_hsa006500.89321749
60Amoebiasis_Homo sapiens_hsa051460.86301504
61Vascular smooth muscle contraction_Homo sapiens_hsa042700.85706759
62Tight junction_Homo sapiens_hsa045300.85391162
63Ovarian steroidogenesis_Homo sapiens_hsa049130.84980898
64Lysine degradation_Homo sapiens_hsa003100.81844498
65Circadian rhythm_Homo sapiens_hsa047100.81632642
66Platelet activation_Homo sapiens_hsa046110.81116939
67Estrogen signaling pathway_Homo sapiens_hsa049150.79827405
68Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.77088400
69Fatty acid elongation_Homo sapiens_hsa000620.75189027
70GnRH signaling pathway_Homo sapiens_hsa049120.74835761
71cGMP-PKG signaling pathway_Homo sapiens_hsa040220.74655664
72Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.73942286
73HIF-1 signaling pathway_Homo sapiens_hsa040660.73724874
74Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.73641224
75Proteoglycans in cancer_Homo sapiens_hsa052050.72824110
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.71692419
77Fatty acid biosynthesis_Homo sapiens_hsa000610.70186850
78Oxytocin signaling pathway_Homo sapiens_hsa049210.68083423
79Gap junction_Homo sapiens_hsa045400.66718860
80VEGF signaling pathway_Homo sapiens_hsa043700.66522402
81Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65260000
82Thyroid cancer_Homo sapiens_hsa052160.64849000
83Pertussis_Homo sapiens_hsa051330.64392778
84Insulin signaling pathway_Homo sapiens_hsa049100.63269740
85Endocytosis_Homo sapiens_hsa041440.63266705
86Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61514988
87Pathways in cancer_Homo sapiens_hsa052000.61187529
88Toxoplasmosis_Homo sapiens_hsa051450.61016423
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60984213
90Ras signaling pathway_Homo sapiens_hsa040140.59923250
91Melanogenesis_Homo sapiens_hsa049160.58580048
92Glycerolipid metabolism_Homo sapiens_hsa005610.57930783
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.53663431
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53420385
95Renal cell carcinoma_Homo sapiens_hsa052110.52762289
96Renin secretion_Homo sapiens_hsa049240.52065102
97AMPK signaling pathway_Homo sapiens_hsa041520.51591547
98TNF signaling pathway_Homo sapiens_hsa046680.50542218
99Other glycan degradation_Homo sapiens_hsa005110.50006740
100MicroRNAs in cancer_Homo sapiens_hsa052060.49267330
101alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.48663214
102Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.48458069
103Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47535912
104Hippo signaling pathway_Homo sapiens_hsa043900.46960488
105Calcium signaling pathway_Homo sapiens_hsa040200.45936343
106Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.45628534
107Sphingolipid signaling pathway_Homo sapiens_hsa040710.45611952
108Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45569781
109Thyroid hormone synthesis_Homo sapiens_hsa049180.45295503
110Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44859444
111Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.44492009
112Gastric acid secretion_Homo sapiens_hsa049710.43073090
113Phenylalanine metabolism_Homo sapiens_hsa003600.43006734
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42937874
115Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.42891598
116Choline metabolism in cancer_Homo sapiens_hsa052310.42121812
117Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.42031858
118Bladder cancer_Homo sapiens_hsa052190.40387957
119Chemical carcinogenesis_Homo sapiens_hsa052040.39547462
120Aldosterone synthesis and secretion_Homo sapiens_hsa049250.39546355
121Pancreatic cancer_Homo sapiens_hsa052120.39235065
122MAPK signaling pathway_Homo sapiens_hsa040100.38488542
123Serotonergic synapse_Homo sapiens_hsa047260.38103636
124Taste transduction_Homo sapiens_hsa047420.38019433
125Long-term depression_Homo sapiens_hsa047300.36988801
126Renin-angiotensin system_Homo sapiens_hsa046140.35861255
127Axon guidance_Homo sapiens_hsa043600.35009264
128cAMP signaling pathway_Homo sapiens_hsa040240.34834932
129Chronic myeloid leukemia_Homo sapiens_hsa052200.34275734
130Glucagon signaling pathway_Homo sapiens_hsa049220.33913618
131Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.33889936
132Retinol metabolism_Homo sapiens_hsa008300.32107110
133TGF-beta signaling pathway_Homo sapiens_hsa043500.31637188
134Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.31087789
135Histidine metabolism_Homo sapiens_hsa003400.30657990
136Tyrosine metabolism_Homo sapiens_hsa003500.29953086
137Steroid hormone biosynthesis_Homo sapiens_hsa001400.28381335
138Biosynthesis of amino acids_Homo sapiens_hsa012300.27961623
139Jak-STAT signaling pathway_Homo sapiens_hsa046300.27093270

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