MMP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1collagen fibril organization (GO:0030199)7.57451351
2chondrocyte proliferation (GO:0035988)7.22313770
3protein heterotrimerization (GO:0070208)6.62947866
4sequestering of extracellular ligand from receptor (GO:0035581)6.07285878
5axon extension involved in axon guidance (GO:0048846)5.84575614
6neuron projection extension involved in neuron projection guidance (GO:1902284)5.84575614
7virion attachment to host cell (GO:0019062)5.59629994
8adhesion of symbiont to host cell (GO:0044650)5.59629994
9* collagen metabolic process (GO:0032963)5.58263468
10* collagen catabolic process (GO:0030574)5.58156517
11mesenchymal-epithelial cell signaling (GO:0060638)5.33553318
12* multicellular organismal macromolecule metabolic process (GO:0044259)5.25179184
13negative regulation of leukocyte chemotaxis (GO:0002689)5.16262101
14* multicellular organismal catabolic process (GO:0044243)5.12985256
15endodermal cell differentiation (GO:0035987)5.05452187
16* multicellular organismal metabolic process (GO:0044236)4.97344398
17skin morphogenesis (GO:0043589)4.79782460
18keratan sulfate catabolic process (GO:0042340)4.79155042
19adhesion of symbiont to host (GO:0044406)4.77656955
20dermatan sulfate biosynthetic process (GO:0030208)4.75427924
21* extracellular matrix disassembly (GO:0022617)4.75022670
22substrate-dependent cell migration (GO:0006929)4.70857312
23iron ion import (GO:0097286)4.69327383
24hyaluronan catabolic process (GO:0030214)4.64163008
25negative regulation of fatty acid transport (GO:2000192)4.47176392
26cartilage development involved in endochondral bone morphogenesis (GO:0060351)4.46233042
27extracellular fibril organization (GO:0043206)4.42990373
28peptidyl-proline hydroxylation (GO:0019511)4.30264041
29dermatan sulfate metabolic process (GO:0030205)4.28997795
30fibril organization (GO:0097435)4.25212768
31cell migration involved in heart development (GO:0060973)4.20649570
32positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr4.18443654
33endocardial cushion development (GO:0003197)4.11644610
34bone trabecula formation (GO:0060346)4.10249887
35regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.09241166
36regulation of transforming growth factor beta1 production (GO:0032908)4.08123993
37regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 3.89718143
38regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.87928127
39positive regulation of chemokine secretion (GO:0090197)3.87676595
40positive regulation of macrophage activation (GO:0043032)3.86978697
41hemidesmosome assembly (GO:0031581)3.78248693
42apoptotic cell clearance (GO:0043277)3.77735486
43hypotonic response (GO:0006971)3.72234641
44peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.71242996
45protein hydroxylation (GO:0018126)3.63336975
46cellular response to vitamin D (GO:0071305)3.60166878
47extracellular negative regulation of signal transduction (GO:1900116)3.58779554
48extracellular regulation of signal transduction (GO:1900115)3.58779554
49complement activation, classical pathway (GO:0006958)3.55972108
50type B pancreatic cell proliferation (GO:0044342)3.53949760
51Golgi transport vesicle coating (GO:0048200)3.51153710
52COPI coating of Golgi vesicle (GO:0048205)3.51153710
53cellular response to vitamin (GO:0071295)3.49556818
54regulation of monocyte chemotaxis (GO:0090025)3.45884630
55endothelial cell morphogenesis (GO:0001886)3.45202918
56* extracellular matrix organization (GO:0030198)3.42141927
57blood vessel maturation (GO:0001955)3.42082802
58decidualization (GO:0046697)3.41462004
59G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.41218327
60negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)3.40885950
61* extracellular structure organization (GO:0043062)3.40727964
62regulation of chemokine-mediated signaling pathway (GO:0070099)3.39621220
63cell migration involved in sprouting angiogenesis (GO:0002042)3.38407743
64plasma membrane repair (GO:0001778)3.34976800
65regulation of plasminogen activation (GO:0010755)3.31961402
66cell adhesion mediated by integrin (GO:0033627)3.29598740
67positive regulation of astrocyte differentiation (GO:0048711)3.27911843
68response to magnesium ion (GO:0032026)3.27109105
69regulation of collagen metabolic process (GO:0010712)3.26378423
70renal filtration (GO:0097205)3.25193587
71chondrocyte development (GO:0002063)3.22346908
72protein localization to endosome (GO:0036010)3.20343937
73response to vitamin D (GO:0033280)3.20308299
74glomerular filtration (GO:0003094)3.17983832
75outer ear morphogenesis (GO:0042473)3.17729702
76chronic inflammatory response (GO:0002544)3.17406369
77positive regulation of osteoblast proliferation (GO:0033690)3.16933522
78negative regulation of smooth muscle cell migration (GO:0014912)3.13168967
79blood vessel endothelial cell migration (GO:0043534)3.10295527
80* cellular response to amino acid stimulus (GO:0071230)3.07790787
81mesodermal cell differentiation (GO:0048333)3.06221650
82metanephric mesenchyme development (GO:0072075)3.04907893
83negative regulation of nitric-oxide synthase activity (GO:0051001)3.03749497
84embryonic process involved in female pregnancy (GO:0060136)3.01293515
85extracellular matrix assembly (GO:0085029)3.00934346
86vascular endothelial growth factor signaling pathway (GO:0038084)2.99730966
87embryo implantation (GO:0007566)2.97795093
88negative regulation of protein localization to plasma membrane (GO:1903077)2.96781760
89wound healing (GO:0042060)2.96407932
90craniofacial suture morphogenesis (GO:0097094)2.96046367
91negative regulation of bone remodeling (GO:0046851)2.95298912
92negative chemotaxis (GO:0050919)2.94806157
93positive regulation of p38MAPK cascade (GO:1900745)2.94026146
94regulation of collagen biosynthetic process (GO:0032965)2.93762287
95positive regulation of fibroblast migration (GO:0010763)2.93568455
96positive regulation of extracellular matrix organization (GO:1903055)2.93250042
97regulation of chemokine secretion (GO:0090196)2.91942860
98cellular response to interferon-alpha (GO:0035457)2.90153184
99stress fiber assembly (GO:0043149)2.89108371
100cell-substrate junction assembly (GO:0007044)2.89084093
101positive regulation of endothelial cell apoptotic process (GO:2000353)2.87028241
102positive regulation of receptor recycling (GO:0001921)2.85439061
103protein retention in ER lumen (GO:0006621)2.84668623
104positive regulation of collagen biosynthetic process (GO:0032967)2.84145471
105basement membrane organization (GO:0071711)2.83468907
106chondroitin sulfate biosynthetic process (GO:0030206)2.83461121
107maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.82729795
108ossification (GO:0001503)2.82350320
109regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.82146450
110import into cell (GO:0098657)2.81874116
111peptide cross-linking (GO:0018149)2.81714043
112response to fluid shear stress (GO:0034405)2.81595129
113regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.80955003
114replacement ossification (GO:0036075)2.79954324
115endochondral ossification (GO:0001958)2.79954324
116complement activation (GO:0006956)2.79208506
117regulation of integrin-mediated signaling pathway (GO:2001044)2.78061169
118negative regulation of axon extension involved in axon guidance (GO:0048843)2.77970414
119negative regulation of homotypic cell-cell adhesion (GO:0034111)2.77891246
120wound healing, spreading of epidermal cells (GO:0035313)2.76960206
121heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.75116401
122regulation of extracellular matrix disassembly (GO:0010715)2.73783591
123vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.73185321
124venous blood vessel morphogenesis (GO:0048845)2.71254397
1254-hydroxyproline metabolic process (GO:0019471)2.70750520
126embryonic cranial skeleton morphogenesis (GO:0048701)2.70443234
127kidney mesenchyme development (GO:0072074)2.67808130
128chondroitin sulfate catabolic process (GO:0030207)2.67335913
129regulation of osteoblast proliferation (GO:0033688)2.67315881
130response to interferon-alpha (GO:0035455)2.67142834
131positive regulation of collagen metabolic process (GO:0010714)2.66273333
132endothelial cell migration (GO:0043542)2.62811049
133glial cell migration (GO:0008347)2.62688216
134positive regulation of bone remodeling (GO:0046852)2.62528218
135positive regulation of bone resorption (GO:0045780)2.62528218
136mammary gland epithelial cell proliferation (GO:0033598)2.62408968
137angiotensin maturation (GO:0002003)2.60960520
138cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.58976989
139regulation of fibroblast migration (GO:0010762)2.58497855
140wound healing, spreading of cells (GO:0044319)2.58037116
141negative regulation of focal adhesion assembly (GO:0051895)2.57832263
142negative regulation of cell junction assembly (GO:1901889)2.57832263
143negative regulation of adherens junction organization (GO:1903392)2.57832263
144glycosaminoglycan catabolic process (GO:0006027)2.57458159
145dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.55604413
146endocrine hormone secretion (GO:0060986)2.55129198
147positive regulation of blood vessel endothelial cell migration (GO:0043536)2.54837850
148positive regulation of mesenchymal cell proliferation (GO:0002053)2.54660077

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human7.13425859
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.94490262
3RARG_19884340_ChIP-ChIP_MEFs_Mouse4.46036468
4PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.34445721
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.09461803
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.06458501
7CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.93906015
8TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.90733676
9CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.88166979
10CLOCK_20551151_ChIP-Seq_293T_Human2.86376227
11RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.71806762
12CJUN_26792858_Chip-Seq_BT549_Human2.58270793
13ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.48625700
14HIF1A_21447827_ChIP-Seq_MCF-7_Human2.42480022
15THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.34500522
16WT1_19549856_ChIP-ChIP_CCG9911_Human2.27572263
17SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.26626393
18NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.08553944
19NRF2_20460467_ChIP-Seq_MEFs_Mouse2.08553944
20BRD4_25478319_ChIP-Seq_HGPS_Human2.03418416
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.97780756
22EGR1_19374776_ChIP-ChIP_THP-1_Human1.89742226
23EP300_21415370_ChIP-Seq_HL-1_Mouse1.87799985
24* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.85967493
25FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.85113364
26ESR1_21235772_ChIP-Seq_MCF-7_Human1.82257125
27SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.82121106
28SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.82121106
29WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.81650035
30IRF8_22096565_ChIP-ChIP_GC-B_Human1.79867671
31PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.75107863
32SMAD_19615063_ChIP-ChIP_OVARY_Human1.74988505
33* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.74754944
34PPAR_26484153_Chip-Seq_NCI-H1993_Human1.71756876
35TP53_18474530_ChIP-ChIP_U2OS_Human1.71033165
36SMC1_22415368_ChIP-Seq_MEFs_Mouse1.54343558
37SOX2_20726797_ChIP-Seq_SW620_Human1.53275058
38TP53_20018659_ChIP-ChIP_R1E_Mouse1.51311496
39ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.50265876
40EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.50067882
41TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49282815
42ESR2_21235772_ChIP-Seq_MCF-7_Human1.48333841
43* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.47901401
44ELK3_25401928_ChIP-Seq_HUVEC_Human1.46734873
45FOXO3_23340844_ChIP-Seq_DLD1_Human1.44296634
46* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.43869431
47AR_21572438_ChIP-Seq_LNCaP_Human1.43203931
48P300_27058665_Chip-Seq_ZR-75-30cells_Human1.40279203
49TP53_16413492_ChIP-PET_HCT116_Human1.38181020
50NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.36989108
51UBF1/2_26484160_Chip-Seq_HMECs_Human1.36566643
52CDX2_19796622_ChIP-Seq_MESCs_Mouse1.35321305
53SOX9_24532713_ChIP-Seq_HFSC_Mouse1.32204354
54EED_16625203_ChIP-ChIP_MESCs_Mouse1.28297498
55CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.26779703
56ATF3_27146783_Chip-Seq_COLON_Human1.26184321
57* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.25917757
58SALL4_18804426_ChIP-ChIP_XEN_Mouse1.25142262
59SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.25093313
60GATA2_21666600_ChIP-Seq_HMVEC_Human1.23057267
61ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.22848402
62ZFP281_18757296_ChIP-ChIP_E14_Mouse1.21236039
63Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.20073375
64EGR1_19032775_ChIP-ChIP_M12_Human1.19970539
65TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.17176902
66UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.14760516
67STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.13612556
68ZNF217_24962896_ChIP-Seq_MCF-7_Human1.13031598
69SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.12746683
70LXR_22292898_ChIP-Seq_THP-1_Human1.10389145
71ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.08829564
72SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.08585445
73TP53_23651856_ChIP-Seq_MEFs_Mouse1.08077557
74STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.07897606
75KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.07050726
76POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.06749572
77SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.06206734
78TP53_22127205_ChIP-Seq_IMR90_Human1.04823870
79SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.04366826
80HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.04328185
81STAT6_21828071_ChIP-Seq_BEAS2B_Human1.04178634
82EZH2_18974828_ChIP-Seq_MESCs_Mouse1.03063639
83RNF2_18974828_ChIP-Seq_MESCs_Mouse1.03063639
84* TP63_23658742_ChIP-Seq_EP156T_Human1.02454506
85FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.01780171
86VDR_24787735_ChIP-Seq_THP-1_Human0.98407260
87NFIB_24661679_ChIP-Seq_LUNG_Mouse0.97956257
88SMC3_22415368_ChIP-Seq_MEFs_Mouse0.95631757
89MYB_21317192_ChIP-Seq_ERMYB_Mouse0.95491093
90TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.95203439
91ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.94802165
92TBX20_22080862_ChIP-Seq_HEART_Mouse0.94605353
93TBX20_22328084_ChIP-Seq_HEART_Mouse0.94605353
94KDM2B_26808549_Chip-Seq_SUP-B15_Human0.94568743
95SA1_22415368_ChIP-Seq_MEFs_Mouse0.94120353
96TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.92980367
97RXR_22108803_ChIP-Seq_LS180_Human0.92400950
98NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.91955611
99NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.91909544
100NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.90191838
101NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.90153522
102ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.88137137
103KLF5_25053715_ChIP-Seq_YYC3_Human0.87216213
104FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.85375922
105RACK7_27058665_Chip-Seq_MCF-7_Human0.85170104
106TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.84161188
107KDM2B_26808549_Chip-Seq_K562_Human0.84083757
108MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.83081191
109ISL1_27105846_Chip-Seq_CPCs_Mouse0.82476806
110KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.82161541
111ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.81995972
112ZNF263_19887448_ChIP-Seq_K562_Human0.77425359
113EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.76881741
114PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.76644214
115TET1_21490601_ChIP-Seq_MESCs_Mouse0.75551045
116SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.74678977
117ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.73693764
118SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.72699767
119IRF8_27001747_Chip-Seq_BMDM_Mouse0.71769535

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen9.16506542
2MP0005275_abnormal_skin_tensile6.33985901
3MP0005503_abnormal_tendon_morphology6.01374181
4MP0003705_abnormal_hypodermis_morpholog4.53923868
5MP0003279_aneurysm3.78260909
6MP0001958_emphysema2.94015016
7* MP0005023_abnormal_wound_healing2.63358777
8MP0002060_abnormal_skin_morphology2.40415067
9MP0006054_spinal_hemorrhage2.25568762
10MP0009384_cardiac_valve_regurgitation2.21024879
11MP0005508_abnormal_skeleton_morphology2.18617140
12MP0002295_abnormal_pulmonary_circulatio2.08790556
13MP0010352_gastrointestinal_tract_polyps2.08228314
14MP0004272_abnormal_basement_membrane2.05133854
15MP0009780_abnormal_chondrocyte_physiolo2.03229584
16MP0005623_abnormal_meninges_morphology1.79875629
17MP0003091_abnormal_cell_migration1.76155824
18MP0002108_abnormal_muscle_morphology1.69934338
19MP0006082_CNS_inflammation1.65184344
20MP0002282_abnormal_trachea_morphology1.64707244
21MP0003045_fibrosis1.64612326
22MP0002896_abnormal_bone_mineralization1.59734052
23MP0001243_abnormal_dermal_layer1.57905583
24* MP0002933_joint_inflammation1.56135677
25MP0009840_abnormal_foam_cell1.56045864
26MP0005390_skeleton_phenotype1.53169200
27MP0003195_calcinosis1.52009406
28MP0003566_abnormal_cell_adhesion1.50831546
29MP0005257_abnormal_intraocular_pressure1.50534875
30MP0003283_abnormal_digestive_organ1.50243989
31MP0005164_abnormal_response_to1.44523672
32MP0009278_abnormal_bone_marrow1.41236399
33MP0001299_abnormal_eye_distance/1.41029687
34MP0000604_amyloidosis1.40888577
35MP0009250_abnormal_appendicular_skeleto1.38307176
36MP0002168_other_aberrant_phenotype1.38202954
37MP0010368_abnormal_lymphatic_system1.36780339
38MP0001533_abnormal_skeleton_physiology1.33376319
39MP0004510_myositis1.30432991
40MP0000343_altered_response_to1.28514333
41MP0000163_abnormal_cartilage_morphology1.24861160
42MP0003191_abnormal_cellular_cholesterol1.23839396
43MP0002115_abnormal_skeleton_extremities1.20764579
44MP0004134_abnormal_chest_morphology1.19946295
45MP0010030_abnormal_orbit_morphology1.15062116
46MP0000733_abnormal_muscle_development1.14641801
47MP0005076_abnormal_cell_differentiation1.11500725
48MP0005171_absent_coat_pigmentation1.09655874
49MP0000751_myopathy1.07942640
50MP0001348_abnormal_lacrimal_gland1.06300392
51MP0000428_abnormal_craniofacial_morphol1.04673561
52MP0003300_gastrointestinal_ulcer1.04024104
53MP0000767_abnormal_smooth_muscle1.03342887
54MP0002998_abnormal_bone_remodeling1.00391016
55MP0002113_abnormal_skeleton_development0.99751068
56MP0003385_abnormal_body_wall0.97488445
57MP0002089_abnormal_postnatal_growth/wei0.97320859
58MP0000579_abnormal_nail_morphology0.96146152
59MP0000750_abnormal_muscle_regeneration0.94889446
60MP0001542_abnormal_bone_strength0.93660348
61MP0003795_abnormal_bone_structure0.93141356
62MP0008004_abnormal_stomach_pH0.92259685
63MP0000534_abnormal_ureter_morphology0.89843919
64MP0001879_abnormal_lymphatic_vessel0.88847751
65MP0005595_abnormal_vascular_smooth0.88044766
66MP0001849_ear_inflammation0.87872842
67MP0003115_abnormal_respiratory_system0.87499033
68MP0003448_altered_tumor_morphology0.86194413
69MP0000681_abnormal_thyroid_gland0.85489332
70MP0010771_integument_phenotype0.84301130
71MP0003303_peritoneal_inflammation0.84160755
72MP0008775_abnormal_heart_ventricle0.82464711
73MP0001835_abnormal_antigen_presentation0.82276603
74MP0005165_increased_susceptibility_to0.81951520
75MP0003329_amyloid_beta_deposits0.79925916
76MP0002133_abnormal_respiratory_system0.79915890
77MP0005388_respiratory_system_phenotype0.79915890
78MP0009053_abnormal_anal_canal0.79600037
79MP0003942_abnormal_urinary_system0.78347924
80MP0000627_abnormal_mammary_gland0.76906412
81MP0002254_reproductive_system_inflammat0.75508749
82MP0002128_abnormal_blood_circulation0.74707861
83MP0002877_abnormal_melanocyte_morpholog0.73895707
84MP0004883_abnormal_blood_vessel0.73601882
85MP0001175_abnormal_lung_morphology0.73418508
86MP0004858_abnormal_nervous_system0.73116962
87MP0005360_urolithiasis0.72314659
88MP0002932_abnormal_joint_morphology0.72089212
89MP0001216_abnormal_epidermal_layer0.71918688
90MP0003453_abnormal_keratinocyte_physiol0.70993560
91MP0003436_decreased_susceptibility_to0.70870526
92MP0005197_abnormal_uvea_morphology0.70516855
93MP0001177_atelectasis0.70359464
94MP0009785_altered_susceptibility_to0.70270532
95MP0010386_abnormal_urinary_bladder0.69716200
96MP0000685_abnormal_immune_system0.67674869
97MP0003828_pulmonary_edema0.66730985
98MP0000858_altered_metastatic_potential0.66590454
99* MP0005166_decreased_susceptibility_to0.64363979
100MP0010307_abnormal_tumor_latency0.62461917
101MP0001614_abnormal_blood_vessel0.62012806
102MP0004947_skin_inflammation0.61051869
103MP0001881_abnormal_mammary_gland0.60732092
104MP0000249_abnormal_blood_vessel0.59941342
105MP0005058_abnormal_lysosome_morphology0.58491220
106MP0003075_altered_response_to0.58055038
107MP0000432_abnormal_head_morphology0.57647024
108MP0002109_abnormal_limb_morphology0.57484604
109MP0002796_impaired_skin_barrier0.57208326
110MP0005451_abnormal_body_composition0.56993908
111MP0003755_abnormal_palate_morphology0.56614855
112MP0003941_abnormal_skin_development0.56444463
113MP0000013_abnormal_adipose_tissue0.54338842
114MP0000762_abnormal_tongue_morphology0.53159295
115MP0004808_abnormal_hematopoietic_stem0.53106240
116MP0003950_abnormal_plasma_membrane0.51063490
117MP0005369_muscle_phenotype0.51061619
118MP0002925_abnormal_cardiovascular_devel0.49072702
119MP0005395_other_phenotype0.48810883
120MP0009931_abnormal_skin_appearance0.48214570
121MP0003724_increased_susceptibility_to0.48044897
122MP0000759_abnormal_skeletal_muscle0.47901965
123MP0000467_abnormal_esophagus_morphology0.47813553
124MP0005501_abnormal_skin_physiology0.47770627
125MP0005193_abnormal_anterior_eye0.47436946

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)8.30308711
2Premature rupture of membranes (HP:0001788)7.02818314
3Ankle contracture (HP:0006466)5.33550533
4Cervical subluxation (HP:0003308)5.25169114
5Broad metatarsal (HP:0001783)5.06724409
6Shallow orbits (HP:0000586)4.46022084
7Aortic dissection (HP:0002647)4.38762487
8Follicular hyperkeratosis (HP:0007502)4.24921731
9Vertebral compression fractures (HP:0002953)4.10921678
10Soft skin (HP:0000977)4.02778416
11Cerebral aneurysm (HP:0004944)3.97806563
12Atrophic scars (HP:0001075)3.97323015
13Ulnar bowing (HP:0003031)3.91936267
14Peritonitis (HP:0002586)3.90227252
15Genu recurvatum (HP:0002816)3.68498303
16Small epiphyses (HP:0010585)3.67168200
17Fragile skin (HP:0001030)3.51404610
18Cupped ribs (HP:0000887)3.48703183
19Wrist flexion contracture (HP:0001239)3.47368825
20Bladder diverticulum (HP:0000015)3.46004500
21Radial bowing (HP:0002986)3.38481284
22Dilatation of the ascending aorta (HP:0005111)3.35869997
23Blue sclerae (HP:0000592)3.31241705
24Type 1 muscle fiber predominance (HP:0003803)3.26024006
25Aortic aneurysm (HP:0004942)3.25419004
26Wormian bones (HP:0002645)3.17590156
27Osteoarthritis (HP:0002758)3.08893103
28Spinal rigidity (HP:0003306)3.00336442
29Abnormality of proline metabolism (HP:0010907)2.99940613
30Hydroxyprolinuria (HP:0003080)2.99940613
31Hypoplastic ischia (HP:0003175)2.97223765
32Bowing of the arm (HP:0006488)2.96462214
33Bowed forearm bones (HP:0003956)2.96462214
34Slender build (HP:0001533)2.95660296
35Mitral valve prolapse (HP:0001634)2.94452291
36Nonimmune hydrops fetalis (HP:0001790)2.94114762
37Abnormality of dentin (HP:0010299)2.88945822
38Mesomelia (HP:0003027)2.84925468
39Achilles tendon contracture (HP:0001771)2.84734868
40Neonatal short-limb short stature (HP:0008921)2.83557230
41Cardiovascular calcification (HP:0011915)2.81700959
42Epiphyseal dysplasia (HP:0002656)2.79168965
43Hypoventilation (HP:0002791)2.76149242
44Coxa vara (HP:0002812)2.71999603
45Biconcave vertebral bodies (HP:0004586)2.70065680
46Vascular tortuosity (HP:0004948)2.68374866
47Bell-shaped thorax (HP:0001591)2.67663581
48Osteolytic defects of the hand bones (HP:0009699)2.66656219
49Osteolytic defects of the phalanges of the hand (HP:0009771)2.66656219
50Hyperextensible skin (HP:0000974)2.61711470
51Abnormality of the ischium (HP:0003174)2.58815245
52Broad ribs (HP:0000885)2.58707819
53Ankyloglossia (HP:0010296)2.57819911
54Sparse lateral eyebrow (HP:0005338)2.57686766
55Abnormality of glycolipid metabolism (HP:0010969)2.57492587
56Abnormality of liposaccharide metabolism (HP:0010968)2.57492587
57Abnormality of glycosphingolipid metabolism (HP:0004343)2.57492587
58Abnormality of the acetabulum (HP:0003170)2.55186625
59Alopecia of scalp (HP:0002293)2.52785010
60Abnormality of the Achilles tendon (HP:0005109)2.51229219
61Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.48878400
62Beaking of vertebral bodies (HP:0004568)2.48683507
63Metaphyseal cupping (HP:0003021)2.47075924
64Femoral bowing (HP:0002980)2.46846835
65Aortic regurgitation (HP:0001659)2.46612017
66Spondylolisthesis (HP:0003302)2.45360324
67Arterial tortuosity (HP:0005116)2.44237992
68Flared iliac wings (HP:0002869)2.43944961
69Joint laxity (HP:0001388)2.40999080
70Abnormal delivery (HP:0001787)2.40609470
71Increased connective tissue (HP:0009025)2.38284925
72Mitral regurgitation (HP:0001653)2.38013857
73Tibial bowing (HP:0002982)2.37065820
74Redundant skin (HP:0001582)2.36372668
75Elbow flexion contracture (HP:0002987)2.34012457
76Spinal cord lesions (HP:0100561)2.32875941
77Syringomyelia (HP:0003396)2.32875941
78Vascular calcification (HP:0004934)2.32491242
79Overgrowth (HP:0001548)2.32238354
80Persistence of primary teeth (HP:0006335)2.31735460
81Increased variability in muscle fiber diameter (HP:0003557)2.31367554
82Natal tooth (HP:0000695)2.29200649
83Bowel diverticulosis (HP:0005222)2.27836279
84Platyspondyly (HP:0000926)2.25678726
85Striae distensae (HP:0001065)2.22379781
86Coronal craniosynostosis (HP:0004440)2.21247782
87Aortic valve stenosis (HP:0001650)2.19418228
88Spinal cord compression (HP:0002176)2.19172737
89Aneurysm (HP:0002617)2.18519676
90Flattened epiphyses (HP:0003071)2.18387307
91Abnormality of oral frenula (HP:0000190)2.18295152
92Narrow nasal bridge (HP:0000446)2.15262135
93Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.15170983
94Generalized amyotrophy (HP:0003700)2.15042324
95Wide anterior fontanel (HP:0000260)2.14765607
96Emphysema (HP:0002097)2.14635878
97Upper limb amyotrophy (HP:0009129)2.13631565
98Distal upper limb amyotrophy (HP:0007149)2.13631565
99Rhizomelia (HP:0008905)2.10688901
100Camptodactyly of toe (HP:0001836)2.10282999
101Ectopia lentis (HP:0001083)2.09639059
102Mitral stenosis (HP:0001718)2.07744341
103Mildly elevated creatine phosphokinase (HP:0008180)2.05689097
104Limb-girdle muscle weakness (HP:0003325)2.05621522
105Abnormality of skeletal muscle fiber size (HP:0012084)2.04549665
106Ovoid vertebral bodies (HP:0003300)2.03664247
107Abnormality of glutamine family amino acid metabolism (HP:0010902)2.03368753
108Flared metaphyses (HP:0003015)2.02980882
109Disproportionate tall stature (HP:0001519)2.01885322
110Hypoplasia of the odontoid process (HP:0003311)1.99188100
111Deviation of the hallux (HP:0010051)1.99107000
112Limited elbow extension (HP:0001377)1.98861279
113Joint stiffness (HP:0001387)1.95779105
114Short nail (HP:0001799)1.95377190
115Thin bony cortex (HP:0002753)1.92921590
116Broad long bones (HP:0005622)1.91827441
117Thoracolumbar scoliosis (HP:0002944)1.90816423
118Abnormality of skull ossification (HP:0002703)1.90457777
119Infantile muscular hypotonia (HP:0008947)1.89643175
120Exostoses (HP:0100777)1.87087762
121Hallux valgus (HP:0001822)1.86450570
122Absent frontal sinuses (HP:0002688)1.85912985
123Delayed closure of the anterior fontanelle (HP:0001476)1.84636218
124Rough bone trabeculation (HP:0100670)1.84435656
125Abnormality of the odontoid process (HP:0003310)1.84010046
126Mild short stature (HP:0003502)1.83128281
127Delayed cranial suture closure (HP:0000270)1.82389525
128Irregular vertebral endplates (HP:0003301)1.81422960
129Tarsal synostosis (HP:0008368)1.81207195
130Obstructive sleep apnea (HP:0002870)1.80928811
131Round ear (HP:0100830)1.79602479
132Breech presentation (HP:0001623)1.75154189
133Protruding ear (HP:0000411)1.72238692
134Osteopenia (HP:0000938)1.70707507
135Decreased skull ossification (HP:0004331)1.69517881
136Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.69182576
137Hand muscle atrophy (HP:0009130)1.68631563
138Abnormality of polysaccharide metabolism (HP:0011012)1.66454051
139Abnormality of glycosaminoglycan metabolism (HP:0004371)1.66454051
140Abnormality of mucopolysaccharide metabolism (HP:0011020)1.66454051
141Mucopolysacchariduria (HP:0008155)1.66127053

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR28.25477598
2AKT34.22552341
3PDGFRA3.99543700
4MYLK3.83766926
5TRIB33.32826827
6TTN2.82467944
7ERN12.76223822
8LATS22.75681101
9PKN22.73429197
10EPHA32.32521706
11MST1R2.22538258
12LATS12.15071735
13EPHB12.01386596
14SIK11.97416991
15EPHB21.92931533
16TGFBR21.90501792
17RIPK11.84100590
18IRAK31.79082138
19PAK41.72421716
20FER1.69996932
21CDC42BPA1.66769534
22PIM21.63524121
23BMX1.60834183
24PDGFRB1.56391849
25STK381.50834409
26PAK21.46226204
27TEC1.44681873
28FLT31.39281164
29LRRK21.38722273
30PAK31.35827672
31NTRK11.34012276
32TRPM71.33289160
33NEK91.29058885
34PTK21.28091219
35NME21.24848391
36SCYL21.23178007
37FGFR41.18432426
38MOS1.17605699
39TESK11.16978218
40FGFR11.13918254
41STK31.12152664
42MET1.09489807
43GRK71.09390596
44JAK11.08827420
45KIT1.08643735
46TAOK21.06571913
47PTK61.06238007
48RPS6KA41.04935521
49PRKCH1.01202322
50ARAF0.99156813
51LIMK10.98091864
52PLK20.94355544
53PRPF4B0.93324081
54ZAP700.90846271
55ABL20.90568690
56GRK50.90212059
57MAP3K30.86323827
58MAP3K60.85443437
59CAMK1D0.83464215
60IKBKE0.81771325
61CDK60.81524491
62FGFR30.78735838
63PTK2B0.78365808
64PRKG20.76360036
65RET0.76164495
66MAPK70.74778792
67RPS6KA20.74456542
68JAK30.74386477
69PAK60.73864133
70FRK0.73677352
71MAP2K30.73603926
72MAP2K10.70036153
73MAP3K130.68993588
74ERBB40.68668440
75GRK60.66135238
76TYK20.65957526
77PRKD20.64830929
78ADRBK20.63989922
79MTOR0.63592095
80SMG10.63527772
81MAP3K120.61533642
82GRK10.58919526
83MAP3K140.58474401
84EEF2K0.56346930
85INSR0.54375955
86ALK0.53359994
87DYRK1B0.52649021
88KSR20.52320021
89ILK0.51267002
90ROCK10.50835921
91DAPK30.47925220
92SRC0.47307636
93PRKD10.46846607
94DMPK0.46125751
95MAPKAPK20.46109159
96GSK3A0.44640331
97PIK3CA0.43841978
98FGFR20.43546222
99TBK10.43541214
100ROCK20.43012661
101TESK20.42729494
102CAMKK20.41953904
103TGFBR10.41756645
104DYRK30.41430263
105MAP3K10.41140791
106MAP3K50.41008324
107MAPKAPK50.39413105
108CAMKK10.39142841
109CAMK2G0.38764328
110PDK20.37956286
111ABL10.37839619
112HCK0.37179079
113CAMK1G0.36274081
114MAPK40.36156558
115PAK10.35930320
116HIPK20.35346753
117IKBKB0.34724898
118EPHA20.31495583
119TAOK10.31241261
120BRAF0.31106812
121RPS6KC10.30668902
122RPS6KL10.30668902
123MAP3K20.30592066
124BLK0.30523817
125FYN0.30183387
126CSK0.29147757
127PIK3CG0.28980523
128EGFR0.28912407
129ADRBK10.28845323
130PRKCE0.26245119
131ERBB30.25269781
132MAPK10.24870541
133JAK20.24567002
134IGF1R0.23555962
135CHUK0.22793433

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.49501481
2Malaria_Homo sapiens_hsa051443.31657001
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.07669724
4Focal adhesion_Homo sapiens_hsa045102.80985293
5Protein digestion and absorption_Homo sapiens_hsa049742.58698191
6Proteoglycans in cancer_Homo sapiens_hsa052052.42497394
7AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.30707994
8Bladder cancer_Homo sapiens_hsa052192.26562413
9Amoebiasis_Homo sapiens_hsa051462.23866612
10Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.87499536
11TGF-beta signaling pathway_Homo sapiens_hsa043501.74784797
12MicroRNAs in cancer_Homo sapiens_hsa052061.66082611
13Sulfur metabolism_Homo sapiens_hsa009201.64300068
14Phagosome_Homo sapiens_hsa041451.62864474
15* TNF signaling pathway_Homo sapiens_hsa046681.62686101
16Small cell lung cancer_Homo sapiens_hsa052221.59927732
17Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.58998919
18Chronic myeloid leukemia_Homo sapiens_hsa052201.55221418
19PI3K-Akt signaling pathway_Homo sapiens_hsa041511.51453269
20Glycosaminoglycan degradation_Homo sapiens_hsa005311.47401611
21Lysosome_Homo sapiens_hsa041421.44272786
22Melanoma_Homo sapiens_hsa052181.42649992
23Central carbon metabolism in cancer_Homo sapiens_hsa052301.41358982
24Adherens junction_Homo sapiens_hsa045201.35503818
25* Rheumatoid arthritis_Homo sapiens_hsa053231.28792519
26Leishmaniasis_Homo sapiens_hsa051401.24065690
27HIF-1 signaling pathway_Homo sapiens_hsa040661.24038209
28Glioma_Homo sapiens_hsa052141.23599710
29Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.22197437
30Pancreatic cancer_Homo sapiens_hsa052121.22103236
31Hematopoietic cell lineage_Homo sapiens_hsa046401.21020269
32Dilated cardiomyopathy_Homo sapiens_hsa054141.18449261
33Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.17502191
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.15302109
35Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.15072793
36Salmonella infection_Homo sapiens_hsa051321.11225919
37Caffeine metabolism_Homo sapiens_hsa002321.10951930
38Hepatitis C_Homo sapiens_hsa051601.10079079
39Pertussis_Homo sapiens_hsa051331.09998867
40Renin-angiotensin system_Homo sapiens_hsa046141.09340415
41Vibrio cholerae infection_Homo sapiens_hsa051101.06002674
42Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.05408461
43Leukocyte transendothelial migration_Homo sapiens_hsa046701.04637825
44Toxoplasmosis_Homo sapiens_hsa051451.03624338
45Regulation of actin cytoskeleton_Homo sapiens_hsa048101.02327454
46N-Glycan biosynthesis_Homo sapiens_hsa005101.02284544
47Hippo signaling pathway_Homo sapiens_hsa043901.00697254
48Pathways in cancer_Homo sapiens_hsa052000.99760051
49Shigellosis_Homo sapiens_hsa051310.98948752
50Complement and coagulation cascades_Homo sapiens_hsa046100.97279783
51Influenza A_Homo sapiens_hsa051640.95561278
52Legionellosis_Homo sapiens_hsa051340.94862854
53Staphylococcus aureus infection_Homo sapiens_hsa051500.94760908
54Basal cell carcinoma_Homo sapiens_hsa052170.92687522
55Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.92634251
56p53 signaling pathway_Homo sapiens_hsa041150.92474373
57Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.91180792
58Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.90535503
59Platelet activation_Homo sapiens_hsa046110.87289315
60Prostate cancer_Homo sapiens_hsa052150.85092263
61Tuberculosis_Homo sapiens_hsa051520.83201222
62Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.82093228
63Axon guidance_Homo sapiens_hsa043600.82047287
64Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.81484483
65African trypanosomiasis_Homo sapiens_hsa051430.80008885
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.79772927
67Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.77591171
68Sphingolipid metabolism_Homo sapiens_hsa006000.77198172
69Renal cell carcinoma_Homo sapiens_hsa052110.75514640
70Prion diseases_Homo sapiens_hsa050200.75122422
71Galactose metabolism_Homo sapiens_hsa000520.74885548
72Osteoclast differentiation_Homo sapiens_hsa043800.74802860
73Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.74376827
74Rap1 signaling pathway_Homo sapiens_hsa040150.74296529
75HTLV-I infection_Homo sapiens_hsa051660.72005362
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70254025
77Hepatitis B_Homo sapiens_hsa051610.70106560
78Measles_Homo sapiens_hsa051620.68887701
79Starch and sucrose metabolism_Homo sapiens_hsa005000.68458412
80Apoptosis_Homo sapiens_hsa042100.67725670
81GnRH signaling pathway_Homo sapiens_hsa049120.67653270
82Viral myocarditis_Homo sapiens_hsa054160.66336503
83Hedgehog signaling pathway_Homo sapiens_hsa043400.65801468
84VEGF signaling pathway_Homo sapiens_hsa043700.64317369
85Estrogen signaling pathway_Homo sapiens_hsa049150.62871318
86Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62817061
87Prolactin signaling pathway_Homo sapiens_hsa049170.62204803
88Insulin resistance_Homo sapiens_hsa049310.60206886
89Mineral absorption_Homo sapiens_hsa049780.58500996
90Endocytosis_Homo sapiens_hsa041440.58046455
91Graft-versus-host disease_Homo sapiens_hsa053320.57969913
92Thyroid cancer_Homo sapiens_hsa052160.57790868
93Toll-like receptor signaling pathway_Homo sapiens_hsa046200.56982382
94Gap junction_Homo sapiens_hsa045400.56875915
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55641865
96NF-kappa B signaling pathway_Homo sapiens_hsa040640.52407943
97Chemokine signaling pathway_Homo sapiens_hsa040620.51473303
98Fructose and mannose metabolism_Homo sapiens_hsa000510.51389734
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.48902538
100Colorectal cancer_Homo sapiens_hsa052100.47693715
101NOD-like receptor signaling pathway_Homo sapiens_hsa046210.47641089
102mTOR signaling pathway_Homo sapiens_hsa041500.47381002
103Neurotrophin signaling pathway_Homo sapiens_hsa047220.47020940
104RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.46523810
105Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46012064
106Ras signaling pathway_Homo sapiens_hsa040140.45948599
107Other glycan degradation_Homo sapiens_hsa005110.45854477
108Melanogenesis_Homo sapiens_hsa049160.45745327
109Viral carcinogenesis_Homo sapiens_hsa052030.45618923
110Thyroid hormone synthesis_Homo sapiens_hsa049180.45367191
111Adipocytokine signaling pathway_Homo sapiens_hsa049200.44109811
112Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.43537455
113Wnt signaling pathway_Homo sapiens_hsa043100.42315826
114Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.41507176
115Acute myeloid leukemia_Homo sapiens_hsa052210.41160926
116Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.40819858
117ErbB signaling pathway_Homo sapiens_hsa040120.40739899
118Jak-STAT signaling pathway_Homo sapiens_hsa046300.36354743

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