MMP23A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nucleoside transport (GO:0015858)9.11792075
2chaperone-mediated protein transport (GO:0072321)8.96868209
3interferon-gamma production (GO:0032609)7.47840544
4nucleotide-sugar biosynthetic process (GO:0009226)5.96563774
5modified amino acid transport (GO:0072337)5.51349721
6peroxisome fission (GO:0016559)5.38230135
7cofactor transport (GO:0051181)5.21875067
8regulation of mitochondrial membrane potential (GO:0051881)5.17752336
9short-chain fatty acid metabolic process (GO:0046459)5.14622981
10pantothenate metabolic process (GO:0015939)5.07124583
11T cell migration (GO:0072678)5.04965294
12cytidine deamination (GO:0009972)4.92378979
13cytidine metabolic process (GO:0046087)4.92378979
14cytidine catabolic process (GO:0006216)4.92378979
15coenzyme A biosynthetic process (GO:0015937)4.82273346
16histone H3-K36 demethylation (GO:0070544)4.54865402
17DNA deamination (GO:0045006)4.50887709
18negative regulation of execution phase of apoptosis (GO:1900118)4.43416328
19negative regulation of cAMP-mediated signaling (GO:0043951)4.38225997
20cellular response to estradiol stimulus (GO:0071392)4.35774954
21pyrimidine ribonucleoside catabolic process (GO:0046133)4.31390420
22outer ear morphogenesis (GO:0042473)4.25363470
23cell migration involved in heart development (GO:0060973)4.12465949
24urinary tract smooth muscle contraction (GO:0014848)3.98491625
25positive regulation of protein kinase C signaling (GO:0090037)3.97674627
26regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.97418367
27sulfur compound transport (GO:0072348)3.82332844
28protein targeting to peroxisome (GO:0006625)3.79523256
29establishment of protein localization to peroxisome (GO:0072663)3.79523256
30protein localization to peroxisome (GO:0072662)3.79523256
31positive regulation of fatty acid beta-oxidation (GO:0032000)3.75708119
32membrane budding (GO:0006900)3.73247314
33peroxisomal transport (GO:0043574)3.71165529
34hemoglobin metabolic process (GO:0020027)3.63777118
35regulation of proton transport (GO:0010155)3.59158571
36positive regulation of interleukin-8 secretion (GO:2000484)3.57728318
37carbohydrate derivative transport (GO:1901264)3.46790905
38regulation of receptor binding (GO:1900120)3.46012627
39positive regulation of transcription regulatory region DNA binding (GO:2000679)3.42217215
40phosphatidylglycerol biosynthetic process (GO:0006655)3.42093979
41endocardial cushion morphogenesis (GO:0003203)3.38840597
42barbed-end actin filament capping (GO:0051016)3.36195223
43lateral ventricle development (GO:0021670)3.34230367
44regulation of histone phosphorylation (GO:0033127)3.34206339
45regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.34093518
46positive regulation of icosanoid secretion (GO:0032305)3.32886023
47nucleoside bisphosphate biosynthetic process (GO:0033866)3.27127247
48purine nucleoside bisphosphate biosynthetic process (GO:0034033)3.27127247
49ribonucleoside bisphosphate biosynthetic process (GO:0034030)3.27127247
50positive regulation of monocyte chemotaxis (GO:0090026)3.20010057
51RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.15558711
52tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.15558711
53striated muscle atrophy (GO:0014891)3.15413616
54lymphocyte chemotaxis (GO:0048247)3.13205878
55positive regulation of defense response to virus by host (GO:0002230)3.11825803
56regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.06209225
57regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.06209225
58antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.04310343
59cranial suture morphogenesis (GO:0060363)3.04077439
60negative regulation of skeletal muscle tissue development (GO:0048642)3.04064549
61viral protein processing (GO:0019082)3.03819672
62positive regulation of myoblast differentiation (GO:0045663)3.01074250
63negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.99591636
64response to misfolded protein (GO:0051788)2.99079943
65positive regulation of fatty acid transport (GO:2000193)2.93665955
66cellular response to estrogen stimulus (GO:0071391)2.91242397
67regulation of interleukin-8 secretion (GO:2000482)2.89214512
68nucleotide-sugar metabolic process (GO:0009225)2.88121252
69muscle atrophy (GO:0014889)2.85282247
70negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.85092064
71lymphocyte migration (GO:0072676)2.84007672
72response to pheromone (GO:0019236)2.81688917
73polarized epithelial cell differentiation (GO:0030859)2.81558746
74monoubiquitinated protein deubiquitination (GO:0035520)2.81248786
75oligosaccharide catabolic process (GO:0009313)2.81160192
76chaperone mediated protein folding requiring cofactor (GO:0051085)2.79834831
77establishment of apical/basal cell polarity (GO:0035089)2.77626792
78muscle cell fate commitment (GO:0042693)2.77470742
79response to muscle activity (GO:0014850)2.74935583
80positive regulation of myotube differentiation (GO:0010831)2.74430185
81homocysteine metabolic process (GO:0050667)2.72792814
82positive regulation of fatty acid oxidation (GO:0046321)2.68400687
83negative regulation of type I interferon production (GO:0032480)2.66880113
84regulation of icosanoid secretion (GO:0032303)2.65647048
85response to inactivity (GO:0014854)2.63965308
86chemokine-mediated signaling pathway (GO:0070098)2.62517717
87homeostasis of number of cells within a tissue (GO:0048873)2.62159471
88negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.61278922
89cytolysis (GO:0019835)2.60349406
90myoblast differentiation (GO:0045445)2.59995244
91platelet aggregation (GO:0070527)2.56850158
92deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.52949297
93peroxisome organization (GO:0007031)2.51563236
94regulation of cellular extravasation (GO:0002691)2.49893424
95viral genome replication (GO:0019079)2.49633987
96exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.48085177
97negative regulation of G-protein coupled receptor protein signaling pathway (GO:0045744)2.44164982
98mannose metabolic process (GO:0006013)15.8354681
99GDP-mannose metabolic process (GO:0019673)13.8292131
100nucleoside transmembrane transport (GO:1901642)11.2723225

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse9.09230157
2ELF1_17652178_ChIP-ChIP_JURKAT_Human4.21249228
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.73783387
4SRY_22984422_ChIP-ChIP_TESTIS_Rat3.52996844
5BP1_19119308_ChIP-ChIP_Hs578T_Human2.99616837
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.76565601
7RARG_19884340_ChIP-ChIP_MEFs_Mouse2.50823294
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.41201348
9RUNX_20019798_ChIP-Seq_JUKART_Human2.36056001
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.31232062
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.23681248
12RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.12649131
13KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.06060556
14KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.06060556
15KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.06060556
16TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.04797456
17STAT4_19710469_ChIP-ChIP_TH1__Mouse2.02691887
18VDR_24763502_ChIP-Seq_THP-1_Human1.98174683
19ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.97844941
20CTCF_27219007_Chip-Seq_ERYTHROID_Human1.94488670
21UTX_26944678_Chip-Seq_JUKART_Human1.87479531
22VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.84494975
23LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.76294116
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.71286232
25MAF_26560356_Chip-Seq_TH1_Human1.71251589
26CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.69898349
27ERG_21242973_ChIP-ChIP_JURKAT_Human1.62496027
28TRIM28_21343339_ChIP-Seq_HEK293_Human1.61115202
29SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human1.61032782
30MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.50814900
31VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.49337610
32BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.49231317
33SA1_27219007_Chip-Seq_Bcells_Human1.48120385
34E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.45564419
35GATA3_27048872_Chip-Seq_THYMUS_Human1.44468638
36MAF_26560356_Chip-Seq_TH2_Human1.42322028
37RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.39247564
38MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.38610542
39EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.32188988
40VDR_24787735_ChIP-Seq_THP-1_Human1.32087256
41POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.31872341
42CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.30378053
43CTCF_27219007_Chip-Seq_Bcells_Human1.28429451
44NOTCH1_21737748_ChIP-Seq_TLL_Human1.28302823
45CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.27290802
46KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.24989547
47UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.24304617
48SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.23792861
49ELK3_25401928_ChIP-Seq_HUVEC_Human1.22694177
50E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.22315780
51LXR_22292898_ChIP-Seq_THP-1_Human1.22065712
52VDR_21846776_ChIP-Seq_THP-1_Human1.21374914
53GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.20757050
54ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.19523885
55TP53_20018659_ChIP-ChIP_R1E_Mouse1.18801746
56LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.17805689
57ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.16016224
58GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.15746960
59GATA1_22025678_ChIP-Seq_K562_Human1.14846928
60YY1_21170310_ChIP-Seq_MESCs_Mouse1.14754123
61KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.14726733
62SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.12986056
63GATA1_19941827_ChIP-Seq_MEL_Mouse1.12646194
64GATA2_21666600_ChIP-Seq_HMVEC_Human1.11574718
65EGR1_19032775_ChIP-ChIP_M12_Human1.10278142
66NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.09949336
67* GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.09172248
68MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.08557981
69STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.07827084
70GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.05748995
71SOX2_21211035_ChIP-Seq_LN229_Human1.04845922
72CTCF_21964334_Chip-Seq_Bcells_Human1.02995281
73P68_20966046_ChIP-Seq_HELA_Human1.02833329
74FOXH1_21741376_ChIP-Seq_ESCs_Human1.00338902
75PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.00204693
76ELF1_20517297_ChIP-Seq_JURKAT_Human1.00065739
77YY1_22570637_ChIP-Seq_MALME-3M_Human0.99176611
78SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98720043
79SA1_27219007_Chip-Seq_ERYTHROID_Human0.97764550
80ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.97175309
81CTCF_20526341_ChIP-Seq_ESCs_Human0.96517969
82RUNX1_22412390_ChIP-Seq_EML_Mouse0.96499879
83NANOG_20526341_ChIP-Seq_ESCs_Human0.95607857
84MYC_22102868_ChIP-Seq_BL_Human0.95134442
85DNAJC2_21179169_ChIP-ChIP_NT2_Human0.94303202
86SPI1_23547873_ChIP-Seq_NB4_Human0.93408770
87PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.93199928
88BCL6_27268052_Chip-Seq_Bcells_Human0.90762960
89PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.90096126
90SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.89976420
91PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.89456365
92RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.88421359
93KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.88098105
94KDM2B_26808549_Chip-Seq_SUP-B15_Human0.86708700
95FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.86302398
96MYB_26560356_Chip-Seq_TH1_Human0.85689971
97KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.85246638
98TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85193043
99FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.84291038
100PPARA_22158963_ChIP-Seq_LIVER_Mouse0.84172918

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002638_abnormal_pupillary_reflex5.82811930
2MP0005671_abnormal_response_to4.68395013
3MP0008260_abnormal_autophagy3.69585463
4MP0006082_CNS_inflammation3.67491413
5MP0001542_abnormal_bone_strength3.13441635
6MP0001727_abnormal_embryo_implantation3.01676964
7MP0003436_decreased_susceptibility_to2.92964335
8MP0009785_altered_susceptibility_to2.68254491
9MP0005387_immune_system_phenotype2.56701689
10MP0001790_abnormal_immune_system2.56701689
11MP0005464_abnormal_platelet_physiology2.49172980
12MP0005503_abnormal_tendon_morphology2.44135456
13MP0009333_abnormal_splenocyte_physiolog2.32319664
14MP0002148_abnormal_hypersensitivity_rea2.20307962
15MP0004858_abnormal_nervous_system2.13628670
16MP0005275_abnormal_skin_tensile2.00643590
17MP0008438_abnormal_cutaneous_collagen2.00201026
18MP0003646_muscle_fatigue1.91301021
19MP0005000_abnormal_immune_tolerance1.87206402
20MP0000343_altered_response_to1.82311875
21MP0006072_abnormal_retinal_apoptosis1.79319135
22MP0000751_myopathy1.77333716
23MP0004043_abnormal_pH_regulation1.76703161
24MP0005025_abnormal_response_to1.74291701
25MP0001533_abnormal_skeleton_physiology1.63634013
26MP0003690_abnormal_glial_cell1.59493024
27MP0009764_decreased_sensitivity_to1.55677115
28MP0001835_abnormal_antigen_presentation1.49029271
29MP0001529_abnormal_vocalization1.48356193
30MP0003763_abnormal_thymus_physiology1.44206581
31MP0010155_abnormal_intestine_physiology1.43290815
32MP0002127_abnormal_cardiovascular_syste1.38537353
33MP0004133_heterotaxia1.36394750
34MP0009379_abnormal_foot_pigmentation1.35212701
35MP0003303_peritoneal_inflammation1.34846288
36MP0001958_emphysema1.32997194
37MP0002420_abnormal_adaptive_immunity1.31705165
38MP0005409_darkened_coat_color1.31649373
39MP0002971_abnormal_brown_adipose1.26959742
40MP0001819_abnormal_immune_cell1.25786672
41MP0002723_abnormal_immune_serum1.25298164
42MP0005166_decreased_susceptibility_to1.23649087
43MP0003890_abnormal_embryonic-extraembry1.23433068
44MP0000678_abnormal_parathyroid_gland1.20820329
45MP0003448_altered_tumor_morphology1.20151931
46MP0002106_abnormal_muscle_physiology1.19504714
47MP0003075_altered_response_to1.18572581
48MP0000013_abnormal_adipose_tissue1.18509370
49MP0002419_abnormal_innate_immunity1.15968071
50MP0005390_skeleton_phenotype1.15355757
51MP0002933_joint_inflammation1.14868650
52MP0001800_abnormal_humoral_immune1.14272832
53MP0002398_abnormal_bone_marrow1.12621226
54MP0003866_abnormal_defecation1.12033449
55MP0002295_abnormal_pulmonary_circulatio1.10320425
56MP0009250_abnormal_appendicular_skeleto1.07123198
57MP0002998_abnormal_bone_remodeling1.05421730
58MP0002452_abnormal_antigen_presenting1.04762225
59MP0001881_abnormal_mammary_gland1.04522845
60MP0008469_abnormal_protein_level1.01733839
61MP0002405_respiratory_system_inflammati1.00917761
62MP0002249_abnormal_larynx_morphology0.99256734
63MP0002722_abnormal_immune_system0.96283282
64MP0005369_muscle_phenotype0.94345212
65MP0009763_increased_sensitivity_to0.92708557
66MP0005645_abnormal_hypothalamus_physiol0.92497357
67MP0005164_abnormal_response_to0.91453765
68MP0000685_abnormal_immune_system0.88994386
69MP0003724_increased_susceptibility_to0.88160675
70MP0001845_abnormal_inflammatory_respons0.88075369
71MP0008873_increased_physiological_sensi0.86587080
72MP0005451_abnormal_body_composition0.86011790
73MP0000716_abnormal_immune_system0.83599643
74MP0010307_abnormal_tumor_latency0.82578506
75MP0004883_abnormal_blood_vessel0.81939517
76MP0004947_skin_inflammation0.80590192
77MP0003828_pulmonary_edema0.79682064
78MP0004264_abnormal_extraembryonic_tissu0.79506699
79MP0003567_abnormal_fetal_cardiomyocyte0.78290888
80MP0002837_dystrophic_cardiac_calcinosis0.77594049
81MP0000689_abnormal_spleen_morphology0.76998268
82MP0000767_abnormal_smooth_muscle0.76861949
83MP0003879_abnormal_hair_cell0.74147887
84MP0000604_amyloidosis0.72623720
85MP0003279_aneurysm0.71095493
86MP0001905_abnormal_dopamine_level0.70623764
87MP0002429_abnormal_blood_cell0.70284975
88MP0001873_stomach_inflammation0.70127039
89MP0009765_abnormal_xenobiotic_induced0.68640656
90MP0008874_decreased_physiological_sensi0.68352640
91MP0005165_increased_susceptibility_to0.67382776
92MP0003300_gastrointestinal_ulcer0.66867485
93MP0003091_abnormal_cell_migration0.66696500
94MP0001849_ear_inflammation0.65661585
95MP0001544_abnormal_cardiovascular_syste0.63072359
96MP0005385_cardiovascular_system_phenoty0.63072359
97MP0008004_abnormal_stomach_pH0.62890185
98MP0003795_abnormal_bone_structure0.61605263
99MP0000049_abnormal_middle_ear0.61515380
100MP0004782_abnormal_surfactant_physiolog0.59928126

Predicted human phenotypes

RankGene SetZ-score
1Global brain atrophy (HP:0002283)9.83535249
2Hypobetalipoproteinemia (HP:0003563)6.63175629
3Neurodegeneration (HP:0002180)6.51060733
4Acanthocytosis (HP:0001927)6.29089525
5Akinesia (HP:0002304)5.85743434
6Abnormality of long-chain fatty-acid metabolism (HP:0010964)5.32822327
7Patent foramen ovale (HP:0001655)5.24858692
8Abnormality of the phalanges of the 2nd finger (HP:0009541)4.62688749
9Brushfield spots (HP:0001088)4.45403485
10Dyskinesia (HP:0100660)3.86661002
11Broad distal phalanx of finger (HP:0009836)3.63395777
12Congenital glaucoma (HP:0001087)3.62737311
13Diminished movement (HP:0002374)3.58785773
14Large eyes (HP:0001090)3.50883100
15Dysphonia (HP:0001618)3.48841608
16Decreased muscle mass (HP:0003199)3.47802755
17Elevated erythrocyte sedimentation rate (HP:0003565)3.41912205
18Hemiplegia (HP:0002301)3.39257766
19Abnormality of fatty-acid metabolism (HP:0004359)3.32351245
20T lymphocytopenia (HP:0005403)3.27022551
21Peritonitis (HP:0002586)3.24655593
22Neurofibrillary tangles (HP:0002185)3.23036898
23Long nose (HP:0003189)3.17958391
24Delayed CNS myelination (HP:0002188)3.15248161
25Orchitis (HP:0100796)3.13632753
26Turricephaly (HP:0000262)3.13516380
27Delayed closure of the anterior fontanelle (HP:0001476)3.11749985
28Abnormality of the basal ganglia (HP:0002134)3.11336875
29Partial duplication of the phalanx of hand (HP:0009999)3.10217477
30Myositis (HP:0100614)3.01915316
31Abnormality of liposaccharide metabolism (HP:0010968)3.01735864
32Abnormality of glycosphingolipid metabolism (HP:0004343)3.01735864
33Abnormality of glycolipid metabolism (HP:0010969)3.01735864
34Abnormality of the 2nd finger (HP:0004100)2.93633795
35Buphthalmos (HP:0000557)2.90160359
36Methylmalonic acidemia (HP:0002912)2.90143384
37Craniofacial dystonia (HP:0012179)2.76967562
38EMG: neuropathic changes (HP:0003445)2.75664222
39Coronal craniosynostosis (HP:0004440)2.68319717
40Hypolipoproteinemia (HP:0010981)2.67598114
41Hyperglycinemia (HP:0002154)2.66922975
42Restlessness (HP:0000711)2.65920515
43Abnormality of T cell number (HP:0011839)2.65157767
44Hypoproteinemia (HP:0003075)2.64863904
45Tubulointerstitial nephritis (HP:0001970)2.60534998
46Shallow orbits (HP:0000586)2.58420399
47Focal dystonia (HP:0004373)2.54576793
48Epiphyseal stippling (HP:0010655)2.53648864
49Impaired smooth pursuit (HP:0007772)2.52648261
50Agitation (HP:0000713)2.49923124
51Amblyopia (HP:0000646)2.49602018
52Rapidly progressive (HP:0003678)2.48015729
53Microretrognathia (HP:0000308)2.44436965
54Stomatitis (HP:0010280)2.44279532
55Delayed epiphyseal ossification (HP:0002663)2.43278032
56Abnormal epiphyseal ossification (HP:0010656)2.40767248
57Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.31527971
58Amyloidosis (HP:0011034)2.29868035
59Neuronal loss in central nervous system (HP:0002529)2.27984256
60Clumsiness (HP:0002312)2.27953347
61Delayed cranial suture closure (HP:0000270)2.21551623
62Posterior embryotoxon (HP:0000627)2.20698892
63Personality changes (HP:0000751)2.20471003
64Cholelithiasis (HP:0001081)2.19488755
65Mediastinal lymphadenopathy (HP:0100721)2.14612013
66Eosinophilia (HP:0001880)2.13345204
67Abnormality of the line of Schwalbe (HP:0008048)2.12588394
68Abnormality of the phalanges of the hallux (HP:0010057)2.12331959
69Poikilocytosis (HP:0004447)2.11703791
70Abnormality of macrophages (HP:0004311)2.11171165
71Axonal loss (HP:0003447)2.09741638
72Episodic fever (HP:0001954)2.09373283
73Flat face (HP:0012368)2.08058551
74Bicuspid aortic valve (HP:0001647)2.07660714
75Abnormality of the parietal bone (HP:0002696)2.06188978
76Hyperbilirubinemia (HP:0002904)2.05919467
77Cerebral inclusion bodies (HP:0100314)2.04610180
78Underdeveloped supraorbital ridges (HP:0009891)2.01978825
79Bradykinesia (HP:0002067)2.01741456
80Ketoacidosis (HP:0001993)1.96210645
81Abnormal gallbladder morphology (HP:0012437)1.95222440
82Postural tremor (HP:0002174)1.94005322
83Infantile muscular hypotonia (HP:0008947)1.91204890
84Leukocytosis (HP:0001974)1.90482799
85Abnormality of the vitamin B12 metabolism (HP:0004341)1.89786007
86Dilatation of the ascending aorta (HP:0005111)1.88500875
87Abnormality of ocular smooth pursuit (HP:0000617)1.87567206
88Cellulitis (HP:0100658)1.86259647
89Granulocytopenia (HP:0001913)1.86045607
90Congenital sensorineural hearing impairment (HP:0008527)1.85308092
91Encephalitis (HP:0002383)1.83091661
92Meningitis (HP:0001287)1.82043178
93Upper motor neuron abnormality (HP:0002127)1.80052172
94Abnormality of vitamin B metabolism (HP:0004340)1.79555550
95Abnormality of the peritoneum (HP:0002585)1.78918313
96Carpal bone hypoplasia (HP:0001498)1.78916589
97Acute hepatic failure (HP:0006554)1.76366465
98Ulnar deviation of the wrist (HP:0003049)1.75611860
99Female pseudohermaphroditism (HP:0010458)1.75395158
100Renal tubular dysfunction (HP:0000124)1.75204973

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN17.94637885
2MAP2K63.55432822
3TESK23.39986298
4STK382.89329311
5PDK22.73312710
6MAP3K62.62344430
7MAP4K12.50029804
8MAP2K32.37707793
9PRKD22.12549634
10TESK11.99384881
11LCK1.71226330
12TRIM281.68368679
13KIT1.67298806
14TXK1.61831827
15AKT21.57781904
16TBK11.51211056
17MAP3K111.51170714
18BTK1.43721615
19ITK1.37217145
20SYK1.37053336
21GRK61.36816842
22CSF1R1.35058041
23GRK71.31862983
24KDR1.30518646
25PASK1.29050817
26FES1.28453954
27ZAP701.23654351
28PDK11.19483870
29PDPK11.12280268
30MAP3K51.08907179
31PIK3CG1.08377587
32TAOK11.05958327
33TAOK21.03776700
34MAP2K41.03008049
35MYLK1.02596332
36PKN11.02163704
37NEK21.01407883
38NME11.00782931
39CSK0.96314409
40PRKCH0.91886397
41TEC0.87346982
42TAOK30.86601306
43MST40.85410059
44DYRK1B0.84121798
45PIM10.83173527
46PRPF4B0.81216548
47FLT30.80113465
48TNK20.78857415
49FYN0.78763708
50RPS6KC10.78420979
51RPS6KL10.78420979
52ROCK20.76919046
53RPS6KA20.72132616
54LIMK10.68211994
55INSR0.65284337
56RPS6KA60.65151049
57HCK0.64184885
58JAK30.63388553
59TIE10.62640812
60DDR20.60472609
61MATK0.59223150
62MAPK40.59035780
63LYN0.58481098
64PIM20.56909926
65YES10.54754246
66ABL20.54049815
67STK30.53556076
68OBSCN0.52543844
69CDK40.52181713
70PRKCD0.50800901
71ROCK10.50605896
72SRPK10.50340583
73TGFBR20.50057114
74CAMK2A0.49000424
75PRKD10.48163434
76MAPK30.47925652
77LMTK20.47502810
78BMX0.47110801
79RPS6KA10.45583036
80GRK50.44141062
81FGR0.43724687
82ADRBK10.42208986
83TTN0.41968769
84ADRBK20.40656876
85PRKCA0.38804991
86STK38L0.38182099
87TGFBR10.36043461
88CAMK2G0.35768647
89IGF1R0.35473821
90MAPK10.35096905
91PRKCG0.34553694
92DAPK30.34403504
93JAK20.34353656
94PRKCQ0.34061796
95RIPK10.33876825
96EGFR0.33760544
97AKT10.33406080
98AURKA0.32849802
99BRAF0.32823498
100DAPK20.31011108

Predicted pathways (KEGG)

RankGene SetZ-score
1Pantothenate and CoA biosynthesis_Homo sapiens_hsa007704.49411055
2Sulfur metabolism_Homo sapiens_hsa009204.39576601
3Fructose and mannose metabolism_Homo sapiens_hsa000514.15573250
4Graft-versus-host disease_Homo sapiens_hsa053322.62313348
5Primary immunodeficiency_Homo sapiens_hsa053402.60788126
6Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.56443747
7Allograft rejection_Homo sapiens_hsa053302.52638343
8Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.45139663
9Autoimmune thyroid disease_Homo sapiens_hsa053202.44551275
10Regulation of autophagy_Homo sapiens_hsa041402.10699595
11Type I diabetes mellitus_Homo sapiens_hsa049402.02461545
12Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.93135181
13Hematopoietic cell lineage_Homo sapiens_hsa046401.84190647
14Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.79022947
15RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.58895001
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.57546343
17Malaria_Homo sapiens_hsa051441.48565721
18Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.46194926
19Linoleic acid metabolism_Homo sapiens_hsa005911.39789368
20Renin-angiotensin system_Homo sapiens_hsa046141.34418125
21Renin secretion_Homo sapiens_hsa049241.30389387
22Staphylococcus aureus infection_Homo sapiens_hsa051501.29709127
23Antigen processing and presentation_Homo sapiens_hsa046121.27336679
24Selenocompound metabolism_Homo sapiens_hsa004501.26933084
25Leishmaniasis_Homo sapiens_hsa051401.26366820
26T cell receptor signaling pathway_Homo sapiens_hsa046601.25707967
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.25294905
28Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.24135499
29Ribosome_Homo sapiens_hsa030101.23565007
30Nitrogen metabolism_Homo sapiens_hsa009101.20102774
31Pertussis_Homo sapiens_hsa051331.19579754
32SNARE interactions in vesicular transport_Homo sapiens_hsa041301.18025274
33Salmonella infection_Homo sapiens_hsa051321.16770656
34Caffeine metabolism_Homo sapiens_hsa002321.11045108
35Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.11016164
36Prion diseases_Homo sapiens_hsa050201.10286173
37Osteoclast differentiation_Homo sapiens_hsa043801.03280805
38Viral myocarditis_Homo sapiens_hsa054161.02303946
39Protein digestion and absorption_Homo sapiens_hsa049740.95319255
40Complement and coagulation cascades_Homo sapiens_hsa046100.88588442
41Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.86631316
42Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.86042179
43Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85265498
44Peroxisome_Homo sapiens_hsa041460.84854112
45Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.83020118
46Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.81272672
47Platelet activation_Homo sapiens_hsa046110.78190876
48Vascular smooth muscle contraction_Homo sapiens_hsa042700.77499628
49Arachidonic acid metabolism_Homo sapiens_hsa005900.76762217
50Leukocyte transendothelial migration_Homo sapiens_hsa046700.74128036
51Shigellosis_Homo sapiens_hsa051310.72526526
52Asthma_Homo sapiens_hsa053100.71586711
53Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.68523140
54African trypanosomiasis_Homo sapiens_hsa051430.68419436
55Chemokine signaling pathway_Homo sapiens_hsa040620.68410229
56Glycosaminoglycan degradation_Homo sapiens_hsa005310.66220927
57Pentose and glucuronate interconversions_Homo sapiens_hsa000400.65057604
58NF-kappa B signaling pathway_Homo sapiens_hsa040640.63866560
59Influenza A_Homo sapiens_hsa051640.63740282
60Rheumatoid arthritis_Homo sapiens_hsa053230.57096303
61Folate biosynthesis_Homo sapiens_hsa007900.56410299
62TNF signaling pathway_Homo sapiens_hsa046680.55821738
63Toll-like receptor signaling pathway_Homo sapiens_hsa046200.55679888
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55153283
65Notch signaling pathway_Homo sapiens_hsa043300.54515232
66NOD-like receptor signaling pathway_Homo sapiens_hsa046210.53932575
67Propanoate metabolism_Homo sapiens_hsa006400.53787283
68ECM-receptor interaction_Homo sapiens_hsa045120.52011590
69Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.50963888
70Lysosome_Homo sapiens_hsa041420.50622373
71RNA degradation_Homo sapiens_hsa030180.49621127
72Maturity onset diabetes of the young_Homo sapiens_hsa049500.49212339
73Amoebiasis_Homo sapiens_hsa051460.48965293
74Glycerophospholipid metabolism_Homo sapiens_hsa005640.47878661
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45489896
76Toxoplasmosis_Homo sapiens_hsa051450.45090224
77Measles_Homo sapiens_hsa051620.44014582
78Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43589037
79HTLV-I infection_Homo sapiens_hsa051660.42564887
80Phagosome_Homo sapiens_hsa041450.41670559
81Hepatitis C_Homo sapiens_hsa051600.40549968
82Ether lipid metabolism_Homo sapiens_hsa005650.40491196
83Tuberculosis_Homo sapiens_hsa051520.39863031
84PPAR signaling pathway_Homo sapiens_hsa033200.39557284
85Intestinal immune network for IgA production_Homo sapiens_hsa046720.38984297
86Jak-STAT signaling pathway_Homo sapiens_hsa046300.38388942
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37905531
88Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.37428163
89Proteoglycans in cancer_Homo sapiens_hsa052050.35753135
90Prolactin signaling pathway_Homo sapiens_hsa049170.34692817
91cAMP signaling pathway_Homo sapiens_hsa040240.34687536
92Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.34624469
93Dilated cardiomyopathy_Homo sapiens_hsa054140.33727331
94Rap1 signaling pathway_Homo sapiens_hsa040150.29380446
95B cell receptor signaling pathway_Homo sapiens_hsa046620.25496528
96Legionellosis_Homo sapiens_hsa051340.25028985
97Apoptosis_Homo sapiens_hsa042100.24920849
98Herpes simplex infection_Homo sapiens_hsa051680.24482064
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.24358009
100PI3K-Akt signaling pathway_Homo sapiens_hsa041510.24146489

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