MMP16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The encoded protein activates MMP2 by cleavage. This gene was once referred to as MT-MMP2, but was renamed as MT-MMP3 or MMP16. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)5.80061849
2presynaptic membrane assembly (GO:0097105)5.18527696
3vocalization behavior (GO:0071625)4.94720432
4presynaptic membrane organization (GO:0097090)4.69253193
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.59158768
6neuron recognition (GO:0008038)4.45535798
7protein localization to synapse (GO:0035418)4.44319934
8startle response (GO:0001964)4.38565361
9postsynaptic membrane organization (GO:0001941)4.36192446
10ionotropic glutamate receptor signaling pathway (GO:0035235)4.35602524
11positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.11759626
12axonal fasciculation (GO:0007413)4.11233962
13neurotransmitter-gated ion channel clustering (GO:0072578)4.07812132
14regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.03625875
15positive regulation of synapse assembly (GO:0051965)4.03167650
16regulation of glutamate receptor signaling pathway (GO:1900449)4.02762163
17regulation of short-term neuronal synaptic plasticity (GO:0048172)4.02122806
18negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.98678434
19regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.93498202
20negative regulation of synaptic transmission, GABAergic (GO:0032229)3.89611243
21glutamate receptor signaling pathway (GO:0007215)3.87525976
22synaptic transmission, glutamatergic (GO:0035249)3.84855535
23righting reflex (GO:0060013)3.71308534
24synaptic vesicle docking involved in exocytosis (GO:0016081)3.70292487
25central nervous system projection neuron axonogenesis (GO:0021952)3.70145384
26neuron-neuron synaptic transmission (GO:0007270)3.63594270
27locomotory exploration behavior (GO:0035641)3.57354106
28regulation of synapse assembly (GO:0051963)3.57284920
29exploration behavior (GO:0035640)3.55303426
30synaptic vesicle exocytosis (GO:0016079)3.43825127
31regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.38886595
32dendritic spine morphogenesis (GO:0060997)3.29657230
33auditory behavior (GO:0031223)3.26365455
34regulation of synaptic transmission, glutamatergic (GO:0051966)3.23729386
35regulation of long-term neuronal synaptic plasticity (GO:0048169)3.20036935
36negative regulation of axon extension involved in axon guidance (GO:0048843)3.18274048
37regulation of excitatory postsynaptic membrane potential (GO:0060079)3.17263751
38innervation (GO:0060384)3.15681072
39regulation of postsynaptic membrane potential (GO:0060078)3.15522547
40gamma-aminobutyric acid signaling pathway (GO:0007214)3.14368083
41synapse assembly (GO:0007416)3.10866682
42glutamate secretion (GO:0014047)3.09933534
43response to pheromone (GO:0019236)3.07619821
44DNA double-strand break processing (GO:0000729)3.06776037
45long-term synaptic potentiation (GO:0060291)3.05734479
46positive regulation of synapse maturation (GO:0090129)3.04956303
47regulation of respiratory system process (GO:0044065)3.04509448
48regulation of synaptic vesicle exocytosis (GO:2000300)3.03922429
49regulation of synapse organization (GO:0050807)3.03519965
50mechanosensory behavior (GO:0007638)2.99584913
51G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.99334568
52dendrite development (GO:0016358)2.97339641
53proline transport (GO:0015824)2.97046067
54cerebral cortex radially oriented cell migration (GO:0021799)2.96189049
55dendrite morphogenesis (GO:0048813)2.95674655
56central nervous system neuron axonogenesis (GO:0021955)2.95079489
57response to auditory stimulus (GO:0010996)2.94929164
58behavioral fear response (GO:0001662)2.89894186
59behavioral defense response (GO:0002209)2.89894186
60negative regulation of axon guidance (GO:1902668)2.89557615
61negative regulation of translation, ncRNA-mediated (GO:0040033)2.88190106
62regulation of translation, ncRNA-mediated (GO:0045974)2.88190106
63negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.88190106
64regulation of synapse maturation (GO:0090128)2.86173581
65inner ear receptor stereocilium organization (GO:0060122)2.86156503
66regulation of respiratory gaseous exchange (GO:0043576)2.85362877
67ganglion development (GO:0061548)2.85074695
68transmission of nerve impulse (GO:0019226)2.84643979
69opioid receptor signaling pathway (GO:0038003)2.84562871
70regulation of neuronal synaptic plasticity (GO:0048168)2.84499512
71cerebellar granule cell differentiation (GO:0021707)2.81879299
72pyrimidine nucleobase catabolic process (GO:0006208)2.81307532
73regulation of axon extension involved in axon guidance (GO:0048841)2.80276507
74atrial cardiac muscle cell action potential (GO:0086014)2.79266203
75regulation of dendritic spine morphogenesis (GO:0061001)2.79192408
76membrane hyperpolarization (GO:0060081)2.78461016
77retinal ganglion cell axon guidance (GO:0031290)2.76416038
78cochlea development (GO:0090102)2.75920009
79negative regulation of stem cell proliferation (GO:2000647)2.75611719
80nonmotile primary cilium assembly (GO:0035058)2.75248647
81positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.73751044
82positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.73023301
83establishment of nucleus localization (GO:0040023)2.72231741
84olfactory bulb development (GO:0021772)2.71834774
85positive regulation of membrane potential (GO:0045838)2.71498067
86cell migration in hindbrain (GO:0021535)2.70682026
87membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.70585668
88gonadal mesoderm development (GO:0007506)2.70014746
89response to histamine (GO:0034776)2.68938592
90neuronal action potential propagation (GO:0019227)2.68336338
91regulation of synaptic vesicle transport (GO:1902803)2.68313378
92regulation of axon guidance (GO:1902667)2.66165584
93serotonin receptor signaling pathway (GO:0007210)2.66063682
94learning (GO:0007612)2.65667451
95nucleobase catabolic process (GO:0046113)2.64149874
96fear response (GO:0042596)2.64020188
97calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.64004434
98layer formation in cerebral cortex (GO:0021819)2.64001780
99synapse organization (GO:0050808)2.63561591
100regulation of neurotransmitter secretion (GO:0046928)2.63199163
101positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.62056425
102axon extension involved in axon guidance (GO:0048846)2.61633670
103neuron projection extension involved in neuron projection guidance (GO:1902284)2.61633670
104acrosome assembly (GO:0001675)2.60170596
105positive regulation of neurotransmitter secretion (GO:0001956)2.59755079
106regulation of synaptic plasticity (GO:0048167)2.59552610
107regulation of dendritic spine development (GO:0060998)2.59185372
108regulation of synaptic transmission, GABAergic (GO:0032228)2.58853470
109synaptic vesicle endocytosis (GO:0048488)2.58696909
110regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.57740447
111negative chemotaxis (GO:0050919)2.56147190
112neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.56044886
113limb bud formation (GO:0060174)2.55992876
114negative regulation of neurotransmitter transport (GO:0051589)2.55834743
115membrane depolarization (GO:0051899)2.55622565
116neurotransmitter secretion (GO:0007269)2.54533931
117auditory receptor cell differentiation (GO:0042491)2.52148140
118dorsal/ventral axis specification (GO:0009950)2.52118451
119cAMP-mediated signaling (GO:0019933)2.50334292
120positive regulation of synaptic transmission, GABAergic (GO:0032230)2.50190217
121cerebral cortex cell migration (GO:0021795)2.47984551
122negative regulation of axon extension (GO:0030517)2.47736390
123homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.47617951
124striatum development (GO:0021756)2.47526601
125dermatan sulfate biosynthetic process (GO:0030208)2.46133903
126artery development (GO:0060840)2.44485295
127detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.42577814
128C4-dicarboxylate transport (GO:0015740)2.38888278
129negative regulation of dendrite development (GO:2000171)2.37145268
130membrane assembly (GO:0071709)2.33306958
131kidney morphogenesis (GO:0060993)2.32747389
132regulation of non-canonical Wnt signaling pathway (GO:2000050)2.31753948
133negative regulation of cytosolic calcium ion concentration (GO:0051481)2.30669979
134mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.28150446
135negative regulation of DNA-dependent DNA replication (GO:2000104)2.27997188
136sympathetic nervous system development (GO:0048485)2.24461146
137spinal cord development (GO:0021510)2.24094251
138positive regulation of dendritic spine morphogenesis (GO:0061003)2.23619064
139inner ear receptor cell development (GO:0060119)2.22383389
140paraxial mesoderm development (GO:0048339)2.21979517
141gamma-aminobutyric acid transport (GO:0015812)2.20226179
142positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.17515599
143regulation of timing of cell differentiation (GO:0048505)2.17504317
144behavioral response to ethanol (GO:0048149)2.17196154
145protein prenylation (GO:0018342)2.16165520
146prenylation (GO:0097354)2.16165520
147replication fork processing (GO:0031297)2.15380793
148regulation of Rac protein signal transduction (GO:0035020)2.12170451
149limb development (GO:0060173)2.12000189
150appendage development (GO:0048736)2.12000189
151dermatan sulfate metabolic process (GO:0030205)2.10316744
152axon extension (GO:0048675)2.02236902
153cardiac right ventricle morphogenesis (GO:0003215)2.02105329
154retina layer formation (GO:0010842)2.01357009
155prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.00474881
156intraciliary transport (GO:0042073)2.00219707
157photoreceptor cell maintenance (GO:0045494)1.99981487
158regulation of development, heterochronic (GO:0040034)1.99729109

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.93429830
2* GBX2_23144817_ChIP-Seq_PC3_Human4.38754357
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.18461673
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.07231364
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.87798657
6* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.73471206
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.70282163
8TAF15_26573619_Chip-Seq_HEK293_Human2.67848992
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.63628313
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.61660924
11* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.50458311
12* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.46919352
13* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.42892502
14* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.42727946
15* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.42727946
16CTBP2_25329375_ChIP-Seq_LNCAP_Human2.32926570
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.32572091
18* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.27039254
19CBX2_27304074_Chip-Seq_ESCs_Mouse2.26660508
20AR_21572438_ChIP-Seq_LNCaP_Human2.23844758
21BMI1_23680149_ChIP-Seq_NPCS_Mouse2.06586469
22PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.05390632
23CTBP1_25329375_ChIP-Seq_LNCAP_Human2.04593837
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.01452243
25RBPJ_22232070_ChIP-Seq_NCS_Mouse2.01416192
26* P300_19829295_ChIP-Seq_ESCs_Human1.98575265
27IGF1R_20145208_ChIP-Seq_DFB_Human1.97914727
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.95408533
29MTF2_20144788_ChIP-Seq_MESCs_Mouse1.92691956
30FUS_26573619_Chip-Seq_HEK293_Human1.90729331
31CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.89218070
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.88113707
33EZH2_27294783_Chip-Seq_ESCs_Mouse1.88054394
34* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.85690618
35* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.84245362
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.82408002
37SUZ12_27294783_Chip-Seq_ESCs_Mouse1.80882331
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.80714267
39* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.78511705
40SMAD4_21799915_ChIP-Seq_A2780_Human1.77777057
41* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.76616533
42* REST_21632747_ChIP-Seq_MESCs_Mouse1.75921978
43RNF2_27304074_Chip-Seq_NSC_Mouse1.72206415
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.63972471
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.62901894
46HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.62460172
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.62421387
48OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.58888608
49TOP2B_26459242_ChIP-Seq_MCF-7_Human1.57467950
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.50241181
51* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48157484
52VDR_22108803_ChIP-Seq_LS180_Human1.47658252
53* EWS_26573619_Chip-Seq_HEK293_Human1.46140381
54ZNF274_21170338_ChIP-Seq_K562_Hela1.45919442
55DROSHA_22980978_ChIP-Seq_HELA_Human1.45749544
56AR_25329375_ChIP-Seq_VCAP_Human1.42444650
57* NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.39851258
58KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.38266087
59SMAD_19615063_ChIP-ChIP_OVARY_Human1.38209582
60FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.38195923
61* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.33877088
62STAT3_23295773_ChIP-Seq_U87_Human1.33065832
63* ER_23166858_ChIP-Seq_MCF-7_Human1.32804998
64* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.30441438
65IKZF1_21737484_ChIP-ChIP_HCT116_Human1.29947775
66* NANOG_18555785_Chip-Seq_ESCs_Mouse1.29528355
67HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.28497491
68* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.28277720
69TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28262772
70POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.28262772
71TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.28127218
72CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27712525
73STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.25768440
74ARNT_22903824_ChIP-Seq_MCF-7_Human1.25119799
75TP53_18474530_ChIP-ChIP_U2OS_Human1.23814893
76SOX2_21211035_ChIP-Seq_LN229_Gbm1.22968238
77REST_18959480_ChIP-ChIP_MESCs_Mouse1.22183220
78RUNX2_22187159_ChIP-Seq_PCA_Human1.22096643
79FLI1_27457419_Chip-Seq_LIVER_Mouse1.21694160
80TBX3_20139965_ChIP-Seq_MESCs_Mouse1.21179976
81PCGF2_27294783_Chip-Seq_ESCs_Mouse1.20996423
82TBX3_20139965_ChIP-Seq_ESCs_Mouse1.20853265
83TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20189305
84MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19665971
85* TCF4_23295773_ChIP-Seq_U87_Human1.19504294
86* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.18778596
87EZH2_27294783_Chip-Seq_NPCs_Mouse1.17742537
88RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.16909854
89* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15709020
90* KDM2B_26808549_Chip-Seq_REH_Human1.15565013
91CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.15332993
92NRF2_20460467_ChIP-Seq_MEFs_Mouse1.14768574
93NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.14768574
94NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13851464
95* JUN_21703547_ChIP-Seq_K562_Human1.13757679
96CDX2_19796622_ChIP-Seq_MESCs_Mouse1.12348073
97* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.12210039
98* CBP_20019798_ChIP-Seq_JUKART_Human1.12210039
99RING1B_27294783_Chip-Seq_ESCs_Mouse1.11823568
100AHR_22903824_ChIP-Seq_MCF-7_Human1.11806432
101MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.11686737
102E2F1_18555785_Chip-Seq_ESCs_Mouse1.11376249
103* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11187437
104PRDM14_20953172_ChIP-Seq_ESCs_Human1.11082331
105KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.10656520
106P53_22127205_ChIP-Seq_FIBROBLAST_Human1.10407309
107* TCF4_22108803_ChIP-Seq_LS180_Human1.10251805
108RING1B_27294783_Chip-Seq_NPCs_Mouse1.09487821
109WT1_19549856_ChIP-ChIP_CCG9911_Human1.08723866
110PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08540054
111FLI1_21867929_ChIP-Seq_TH2_Mouse1.08127738
112LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08073939
113TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.07801613
114TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07707997
115E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.07250060
116* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05956025
117P53_22387025_ChIP-Seq_ESCs_Mouse1.05676049
118RARB_27405468_Chip-Seq_BRAIN_Mouse1.05031645
119NR3C1_23031785_ChIP-Seq_PC12_Mouse1.05025519
120SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03185765
121BCAT_22108803_ChIP-Seq_LS180_Human1.02895847
122CMYC_18555785_Chip-Seq_ESCs_Mouse1.02615949
123SOX9_26525672_Chip-Seq_HEART_Mouse1.02613661
124YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02473743
125* AR_19668381_ChIP-Seq_PC3_Human1.01544723

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.47337160
2MP0004859_abnormal_synaptic_plasticity3.71301596
3MP0003635_abnormal_synaptic_transmissio2.95537799
4MP0001968_abnormal_touch/_nociception2.82119481
5MP0002063_abnormal_learning/memory/cond2.57270690
6MP0009745_abnormal_behavioral_response2.52509339
7MP0002572_abnormal_emotion/affect_behav2.44133325
8MP0002736_abnormal_nociception_after2.43052643
9MP0006276_abnormal_autonomic_nervous2.38337417
10MP0004270_analgesia2.32899813
11MP0000778_abnormal_nervous_system2.29109791
12MP0002064_seizures2.28614391
13MP0002735_abnormal_chemical_nociception2.28355889
14MP0001486_abnormal_startle_reflex2.25946313
15MP0003122_maternal_imprinting2.24856507
16MP0003787_abnormal_imprinting2.24835956
17MP0000569_abnormal_digit_pigmentation2.15929683
18MP0009046_muscle_twitch2.10550152
19MP0001188_hyperpigmentation2.09417244
20MP0005423_abnormal_somatic_nervous2.09066668
21MP0002184_abnormal_innervation2.04130912
22MP0001440_abnormal_grooming_behavior2.01650215
23MP0002734_abnormal_mechanical_nocicepti2.00893773
24MP0001529_abnormal_vocalization1.97010567
25MP0002557_abnormal_social/conspecific_i1.82688776
26MP0005646_abnormal_pituitary_gland1.81896736
27MP0002272_abnormal_nervous_system1.81327207
28MP0002067_abnormal_sensory_capabilities1.79116748
29MP0001984_abnormal_olfaction1.75104631
30MP0000566_synostosis1.73551580
31MP0003941_abnormal_skin_development1.73477363
32MP0002254_reproductive_system_inflammat1.72147606
33MP0008877_abnormal_DNA_methylation1.68191656
34MP0002733_abnormal_thermal_nociception1.64563837
35MP0009250_abnormal_appendicular_skeleto1.61080025
36MP0006072_abnormal_retinal_apoptosis1.58990493
37MP0001501_abnormal_sleep_pattern1.57824098
38MP0001970_abnormal_pain_threshold1.54742993
39MP0003385_abnormal_body_wall1.54719745
40MP0003121_genomic_imprinting1.53847142
41MP0005503_abnormal_tendon_morphology1.51045823
42MP0003890_abnormal_embryonic-extraembry1.49652744
43MP0004885_abnormal_endolymph1.45774158
44MP0005386_behavior/neurological_phenoty1.44639196
45MP0004924_abnormal_behavior1.44639196
46MP0008057_abnormal_DNA_replication1.43959492
47MP0002163_abnormal_gland_morphology1.43649351
48MP0005171_absent_coat_pigmentation1.42490995
49MP0005409_darkened_coat_color1.41911747
50MP0005645_abnormal_hypothalamus_physiol1.39788751
51MP0000955_abnormal_spinal_cord1.39517285
52MP0004133_heterotaxia1.37224587
53MP0004742_abnormal_vestibular_system1.36696677
54MP0006292_abnormal_olfactory_placode1.30203513
55MP0004272_abnormal_basement_membrane1.30180957
56MP0005253_abnormal_eye_physiology1.30066128
57MP0002102_abnormal_ear_morphology1.29681706
58MP0000534_abnormal_ureter_morphology1.29134760
59MP0001293_anophthalmia1.27543753
60MP0004858_abnormal_nervous_system1.27412265
61MP0000631_abnormal_neuroendocrine_gland1.27185234
62MP0005551_abnormal_eye_electrophysiolog1.26906448
63MP0009780_abnormal_chondrocyte_physiolo1.22455111
64MP0002882_abnormal_neuron_morphology1.22309954
65MP0005187_abnormal_penis_morphology1.21639999
66MP0005367_renal/urinary_system_phenotyp1.20546515
67MP0000516_abnormal_urinary_system1.20546515
68MP0004142_abnormal_muscle_tone1.20207718
69MP0003942_abnormal_urinary_system1.20151149
70MP0001905_abnormal_dopamine_level1.19172394
71MP0001299_abnormal_eye_distance/1.16899770
72MP0003119_abnormal_digestive_system1.15021482
73MP0010386_abnormal_urinary_bladder1.13480132
74MP0004811_abnormal_neuron_physiology1.13271572
75MP0003755_abnormal_palate_morphology1.12938731
76MP0003938_abnormal_ear_development1.12909540
77MP0000026_abnormal_inner_ear1.09657141
78MP0003935_abnormal_craniofacial_develop1.08178202
79MP0002249_abnormal_larynx_morphology1.08173403
80MP0008438_abnormal_cutaneous_collagen1.07568772
81MP0002152_abnormal_brain_morphology1.07158060
82MP0002697_abnormal_eye_size1.06724708
83MP0006054_spinal_hemorrhage1.06173381
84MP0001485_abnormal_pinna_reflex1.05285427
85MP0005379_endocrine/exocrine_gland_phen1.05117688
86MP0002066_abnormal_motor_capabilities/c1.04623550
87MP0002638_abnormal_pupillary_reflex1.04599302
88MP0002751_abnormal_autonomic_nervous1.04474544
89MP0003136_yellow_coat_color1.04423287
90MP0001963_abnormal_hearing_physiology1.03569332
91MP0008569_lethality_at_weaning1.02244030
92MP0002876_abnormal_thyroid_physiology1.00194035
93MP0000049_abnormal_middle_ear1.00081378
94MP0003123_paternal_imprinting0.98576832
95MP0001286_abnormal_eye_development0.98161643
96MP0002938_white_spotting0.97828292
97MP0005623_abnormal_meninges_morphology0.96622907
98MP0001879_abnormal_lymphatic_vessel0.95028131
99MP0002090_abnormal_vision0.94769906
100MP0002752_abnormal_somatic_nervous0.94599174
101MP0000427_abnormal_hair_cycle0.92359544
102* MP0002116_abnormal_craniofacial_bone0.90865049
103MP0003861_abnormal_nervous_system0.90370318
104MP0003283_abnormal_digestive_organ0.90156857
105MP0005195_abnormal_posterior_eye0.90128394
106MP0005391_vision/eye_phenotype0.89117238
107MP0002233_abnormal_nose_morphology0.88349996
108MP0002282_abnormal_trachea_morphology0.88164977
109MP0004145_abnormal_muscle_electrophysio0.84478016
110MP0002081_perinatal_lethality0.81958583
111MP0001177_atelectasis0.81334382
112MP0000647_abnormal_sebaceous_gland0.79579684
113MP0004215_abnormal_myocardial_fiber0.79401204
114MP0008058_abnormal_DNA_repair0.78960598
115MP0003879_abnormal_hair_cell0.78308906
116MP0000432_abnormal_head_morphology0.78013732
117MP0004484_altered_response_of0.77690454
118MP0000428_abnormal_craniofacial_morphol0.77535663
119MP0005394_taste/olfaction_phenotype0.77132509
120MP0005499_abnormal_olfactory_system0.77132509
121MP0002084_abnormal_developmental_patter0.77089157
122MP0005248_abnormal_Harderian_gland0.76849770
123MP0010368_abnormal_lymphatic_system0.75909462
124MP0004134_abnormal_chest_morphology0.75880813
125MP0002177_abnormal_outer_ear0.75623827
126MP0002837_dystrophic_cardiac_calcinosis0.75531017
127MP0000538_abnormal_urinary_bladder0.74362932
128MP0001502_abnormal_circadian_rhythm0.74067986
129MP0000015_abnormal_ear_pigmentation0.72831638
130MP0004085_abnormal_heartbeat0.71504953
131MP0002653_abnormal_ependyma_morphology0.70727274
132MP0003937_abnormal_limbs/digits/tail_de0.70613886
133MP0005257_abnormal_intraocular_pressure0.70023745
134MP0001958_emphysema0.69753081

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.31109607
2Hyperventilation (HP:0002883)4.18690870
3Epileptic encephalopathy (HP:0200134)3.90010515
4Febrile seizures (HP:0002373)3.88484316
5Focal seizures (HP:0007359)3.60152935
6Broad-based gait (HP:0002136)3.37488742
7Atonic seizures (HP:0010819)3.34697088
8Progressive cerebellar ataxia (HP:0002073)3.10919915
9Hepatoblastoma (HP:0002884)2.98751345
10Absent speech (HP:0001344)2.97775293
11Myokymia (HP:0002411)2.94784214
12Abnormal hair whorl (HP:0010721)2.70291715
13Molar tooth sign on MRI (HP:0002419)2.60216411
14Abnormality of midbrain morphology (HP:0002418)2.60216411
15Volvulus (HP:0002580)2.53300737
16Gait imbalance (HP:0002141)2.51907417
17Drooling (HP:0002307)2.51286345
18Excessive salivation (HP:0003781)2.51286345
19Absence seizures (HP:0002121)2.50941753
20Protruding tongue (HP:0010808)2.49041251
21Intestinal atresia (HP:0011100)2.47963865
22Morphological abnormality of the middle ear (HP:0008609)2.47092139
23Colon cancer (HP:0003003)2.47028941
24Abnormality of incisor morphology (HP:0011063)2.45635351
25Chronic hepatic failure (HP:0100626)2.42123559
26Limb dystonia (HP:0002451)2.38244517
27Dynein arm defect of respiratory motile cilia (HP:0012255)2.33822777
28Absent/shortened dynein arms (HP:0200106)2.33822777
29Dialeptic seizures (HP:0011146)2.30778179
30Medial flaring of the eyebrow (HP:0010747)2.28086579
31Astrocytoma (HP:0009592)2.27045994
32Abnormality of the astrocytes (HP:0100707)2.27045994
33Hemiparesis (HP:0001269)2.24803939
34Bifid tongue (HP:0010297)2.24676247
35Generalized tonic-clonic seizures (HP:0002069)2.23490814
36Pancreatic cysts (HP:0001737)2.22826837
37Genital tract atresia (HP:0001827)2.18743328
38Aplasia/Hypoplasia of the tibia (HP:0005772)2.17488159
39Short tibia (HP:0005736)2.16780177
40Agitation (HP:0000713)2.16361830
41Fetal akinesia sequence (HP:0001989)2.14882637
42Abnormality of the renal medulla (HP:0100957)2.14685760
43Nephrogenic diabetes insipidus (HP:0009806)2.14356957
44Congenital primary aphakia (HP:0007707)2.13143704
45Abnormality of the labia minora (HP:0012880)2.12032977
46Absent eyebrow (HP:0002223)2.10989997
47Vaginal atresia (HP:0000148)2.07540755
48Cutaneous finger syndactyly (HP:0010554)2.06040681
49Aplasia/Hypoplasia of the tongue (HP:0010295)2.04878506
50True hermaphroditism (HP:0010459)2.04578276
51Blue irides (HP:0000635)2.02225647
52Aplasia/Hypoplasia of the sternum (HP:0006714)2.00336696
53Aplasia/Hypoplasia of the lens (HP:0008063)2.00291097
54Gaze-evoked nystagmus (HP:0000640)2.00210545
55Polyphagia (HP:0002591)1.97990344
56Narrow nasal bridge (HP:0000446)1.96876391
57Vitreoretinal degeneration (HP:0000655)1.96677317
58Abnormal ciliary motility (HP:0012262)1.95945055
59Anophthalmia (HP:0000528)1.94620008
60Renal hypoplasia (HP:0000089)1.93227513
61Visual hallucinations (HP:0002367)1.92805366
62Abnormality of the nasolacrimal system (HP:0000614)1.91814058
63Midline defect of the nose (HP:0004122)1.91171905
64Impaired vibration sensation in the lower limbs (HP:0002166)1.90175932
65Glioma (HP:0009733)1.89726395
66Omphalocele (HP:0001539)1.89568539
67Widely spaced teeth (HP:0000687)1.87850508
68Abnormality of the lacrimal duct (HP:0011481)1.87535530
69Bradycardia (HP:0001662)1.87469242
70Pancreatic fibrosis (HP:0100732)1.86784255
71Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.86760101
72Amblyopia (HP:0000646)1.86676743
73Occipital encephalocele (HP:0002085)1.86588815
74Abnormality of the ischium (HP:0003174)1.86176261
75Preaxial foot polydactyly (HP:0001841)1.86004454
76Exotropia (HP:0000577)1.85480803
77Neoplasm of the oral cavity (HP:0100649)1.85385751
78Gastrointestinal atresia (HP:0002589)1.84914876
79Abnormality of salivation (HP:0100755)1.84872287
80Fair hair (HP:0002286)1.84410321
81Sleep apnea (HP:0010535)1.82903085
82Hypoventilation (HP:0002791)1.82891624
83Poor coordination (HP:0002370)1.82626603
84Cutaneous syndactyly (HP:0012725)1.82357318
85Papillary thyroid carcinoma (HP:0002895)1.81220243
86Esotropia (HP:0000565)1.80260307
87Truncal ataxia (HP:0002078)1.80255165
88Overgrowth (HP:0001548)1.80108216
89Labial hypoplasia (HP:0000066)1.78864363
90Short foot (HP:0001773)1.78173171
91Gastroesophageal reflux (HP:0002020)1.77515383
92Epileptiform EEG discharges (HP:0011182)1.77085647
93Lissencephaly (HP:0001339)1.77015364
94Small hand (HP:0200055)1.76819651
95Ependymoma (HP:0002888)1.76583347
96Mild short stature (HP:0003502)1.75986204
97Neoplasm of the adrenal cortex (HP:0100641)1.75266137
98Cupped ear (HP:0000378)1.74894038
99Micropenis (HP:0000054)1.73854224
100Specific learning disability (HP:0001328)1.73218525
101Action tremor (HP:0002345)1.73076460
102Growth hormone deficiency (HP:0000824)1.72256256
103Aplasia involving bones of the extremities (HP:0009825)1.71877172
104Aplasia involving bones of the upper limbs (HP:0009823)1.71877172
105Aplasia of the phalanges of the hand (HP:0009802)1.71877172
106Hypoplastic ischia (HP:0003175)1.71620760
107Nephronophthisis (HP:0000090)1.71517466
108Microglossia (HP:0000171)1.71361864
109Abnormality of the nasal septum (HP:0000419)1.70982102
110Postaxial hand polydactyly (HP:0001162)1.70291604
111Chorioretinal atrophy (HP:0000533)1.70238188
112Enlarged penis (HP:0000040)1.70070451
113Generalized hypopigmentation of hair (HP:0011358)1.69720690
114Sclerocornea (HP:0000647)1.68587761
115Abdominal situs inversus (HP:0003363)1.67455460
116Abnormality of abdominal situs (HP:0011620)1.67455460
117Intellectual disability, moderate (HP:0002342)1.67283725
118Aqueductal stenosis (HP:0002410)1.67078091
119Poor eye contact (HP:0000817)1.66391570
120Optic nerve hypoplasia (HP:0000609)1.66202400
121Postaxial foot polydactyly (HP:0001830)1.65954102
122Hypoplastic female external genitalia (HP:0012815)1.64856017
123Hypothermia (HP:0002045)1.64730279
124Thyroid carcinoma (HP:0002890)1.64554648
125Genetic anticipation (HP:0003743)1.63725666
126Nephroblastoma (Wilms tumor) (HP:0002667)1.63291875
127Fibular hypoplasia (HP:0003038)1.63280022
128Preaxial hand polydactyly (HP:0001177)1.62867617
129Inability to walk (HP:0002540)1.62701604
130Anencephaly (HP:0002323)1.62224748
131Oligodactyly (hands) (HP:0001180)1.61190359
132Choanal stenosis (HP:0000452)1.60964476
133Atrioventricular canal defect (HP:0006695)1.60458165
134Embryonal renal neoplasm (HP:0011794)1.60431623
135Nasolacrimal duct obstruction (HP:0000579)1.60095733
136Abnormal respiratory motile cilium morphology (HP:0005938)1.59871080
137Abnormal respiratory epithelium morphology (HP:0012253)1.59871080
138Septo-optic dysplasia (HP:0100842)1.59604759
139Chorioretinal coloboma (HP:0000567)1.59198603
140Heterochromia iridis (HP:0001100)1.58961607
141Narrow forehead (HP:0000341)1.58646091
142Hypoplastic labia majora (HP:0000059)1.58239969
143EEG with generalized epileptiform discharges (HP:0011198)1.58050568
144Dysdiadochokinesis (HP:0002075)1.56556148
145Coronal craniosynostosis (HP:0004440)1.56425852
146Prominent supraorbital ridges (HP:0000336)1.56232006
147Increased corneal curvature (HP:0100692)1.55314611
148Keratoconus (HP:0000563)1.55314611
149Pachygyria (HP:0001302)1.53310181
150Benign neoplasm of the central nervous system (HP:0100835)1.51868369
151Broad foot (HP:0001769)1.51644466
152Abnormal lung lobation (HP:0002101)1.51594269
153Scrotal hypoplasia (HP:0000046)1.51019119
154Ectopic kidney (HP:0000086)1.50530655
155Retinal dysplasia (HP:0007973)1.49833969
156Dandy-Walker malformation (HP:0001305)1.48107948

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK6.39900477
2EPHA43.44089803
3SIK33.22532401
4MARK13.16571452
5NTRK33.08726460
6MAP2K72.89431581
7TAF12.79351316
8MAP3K42.76452553
9PRPF4B2.62111146
10PRKD32.48789678
11NTRK22.29126679
12MAPK132.14199983
13MAP3K122.07444958
14SIK21.95741458
15TRIM281.94938499
16TNIK1.84291872
17BCR1.80845071
18PLK21.77230050
19MINK11.67346404
20MKNK11.62596226
21CDK191.42579454
22PNCK1.39888473
23KSR11.39818743
24MAP4K21.38500872
25BRSK21.37604595
26ERBB31.33572546
27AKT31.30913545
28FGFR21.28110835
29MAP2K41.27890535
30STK391.27552402
31STK38L1.26531784
32EPHA31.17562839
33DDR21.14462484
34PHKG11.10695361
35PHKG21.10695361
36TAOK21.09606514
37BRD41.09555484
38DYRK21.08999945
39TIE11.06513322
40PRKCG1.02551826
41GRK11.02056683
42CAMK2A0.98594787
43SGK20.98324736
44PRKCE0.94879921
45OXSR10.93052459
46MAP3K90.92339041
47BMPR1B0.91801876
48BMPR20.90110008
49PAK60.89533002
50SGK2230.88814699
51SGK4940.88814699
52CDK50.88229758
53ACVR1B0.83975581
54GRK70.83515171
55CSNK1G20.83085742
56EIF2AK30.82969351
57MKNK20.82297743
58DAPK20.82240584
59ADRBK20.81457189
60TSSK60.80490937
61GRK50.80367946
62ERBB40.79484881
63DYRK1A0.79184131
64WNK30.77766166
65CAMK2B0.77027608
66CDC70.75043027
67WEE10.73988710
68PDGFRA0.72124038
69STK30.71489907
70LATS20.70930435
71DAPK10.70115684
72YES10.69718405
73ADRBK10.67668836
74NEK10.67439221
75CDK30.66086467
76PINK10.65907250
77FGR0.64753971
78CSNK1A1L0.64665433
79FGFR10.64583708
80NUAK10.64197851
81CAMK1G0.63920974
82NLK0.63814877
83VRK10.62961603
84MUSK0.62238748
85UHMK10.61299289
86EPHB20.61099359
87CSNK1G30.60410115
88ZAK0.59242637
89PAK30.58426510
90SGK10.57778885
91PKN10.57706054
92INSRR0.57570167
93BUB10.57339122
94FER0.57103534
95MARK20.57085878
96PTK2B0.56941339
97WNK10.56268004
98MAP3K60.56054780
99LATS10.55443986
100STK160.54117743
101NEK60.52865568
102CAMK40.52712985
103PLK30.52376253
104PRKCZ0.52080546
105CCNB10.51629284
106PLK10.49424454
107DYRK30.49275101
108CAMK10.49178767
109TTK0.48373932
110PLK40.48189028
111RIPK40.48168691
112CAMKK20.47276786
113CDK180.46844858
114EIF2AK20.46759436
115SRPK10.46524614
116BRSK10.46260924
117CDK80.45715500
118RPS6KA20.44747134
119ATM0.44476030
120FRK0.43242770
121PIK3CA0.43079412
122PRKG10.41817672
123CSNK1G10.40827202
124CSNK1E0.40049688
125SGK30.39784572
126CSNK1D0.38853857
127CAMK2D0.37244292
128ROCK20.36557596
129NTRK10.35315612
130PRKCH0.35146791
131STK110.34519235
132ROCK10.34230537
133ARAF0.34022366
134BRAF0.33435729
135TGFBR10.33422860
136CDK140.33232346
137PRKDC0.32999871
138CSNK1A10.32900783
139PTK20.32537529
140GSK3A0.32213814

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.50330751
2Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.78741081
3Synaptic vesicle cycle_Homo sapiens_hsa047212.72315729
4Morphine addiction_Homo sapiens_hsa050322.44827183
5Olfactory transduction_Homo sapiens_hsa047402.44323863
6Glutamatergic synapse_Homo sapiens_hsa047242.42164454
7Circadian entrainment_Homo sapiens_hsa047132.37066240
8GABAergic synapse_Homo sapiens_hsa047272.31075776
9Taste transduction_Homo sapiens_hsa047422.24967816
10Amphetamine addiction_Homo sapiens_hsa050312.19641554
11Serotonergic synapse_Homo sapiens_hsa047262.14472376
12Axon guidance_Homo sapiens_hsa043602.07417511
13Long-term potentiation_Homo sapiens_hsa047202.03526865
14Collecting duct acid secretion_Homo sapiens_hsa049662.00864434
15Dopaminergic synapse_Homo sapiens_hsa047281.99557500
16Protein export_Homo sapiens_hsa030601.87513556
17Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.84939588
18Cocaine addiction_Homo sapiens_hsa050301.73689227
19Long-term depression_Homo sapiens_hsa047301.73065753
20Non-homologous end-joining_Homo sapiens_hsa034501.65032686
21Calcium signaling pathway_Homo sapiens_hsa040201.62627043
22Salivary secretion_Homo sapiens_hsa049701.61688242
23Cholinergic synapse_Homo sapiens_hsa047251.60025717
24Renin secretion_Homo sapiens_hsa049241.56297338
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.54022793
26Basal transcription factors_Homo sapiens_hsa030221.52748989
27Insulin secretion_Homo sapiens_hsa049111.46478725
28Selenocompound metabolism_Homo sapiens_hsa004501.46225525
29Vitamin B6 metabolism_Homo sapiens_hsa007501.46035950
30Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.43413857
31Propanoate metabolism_Homo sapiens_hsa006401.40432291
32Vibrio cholerae infection_Homo sapiens_hsa051101.40302946
33Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.38955224
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.38568782
35Oxytocin signaling pathway_Homo sapiens_hsa049211.37072787
36Steroid biosynthesis_Homo sapiens_hsa001001.34253397
37Aldosterone synthesis and secretion_Homo sapiens_hsa049251.30528058
38Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.27740704
39Gap junction_Homo sapiens_hsa045401.26552451
40Gastric acid secretion_Homo sapiens_hsa049711.24815643
41Phototransduction_Homo sapiens_hsa047441.22142580
42Fanconi anemia pathway_Homo sapiens_hsa034601.21532074
43Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.18968064
44Butanoate metabolism_Homo sapiens_hsa006501.18831847
45Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.18256009
46Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.16828563
47ErbB signaling pathway_Homo sapiens_hsa040121.15779449
48GnRH signaling pathway_Homo sapiens_hsa049121.13642945
49cAMP signaling pathway_Homo sapiens_hsa040241.12982853
50Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.11744267
51Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.07678787
52Lysine degradation_Homo sapiens_hsa003101.06987583
53Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.06284576
54Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.03378615
55Tight junction_Homo sapiens_hsa045301.02286125
56Melanogenesis_Homo sapiens_hsa049161.02136508
57Wnt signaling pathway_Homo sapiens_hsa043100.99590387
58RNA degradation_Homo sapiens_hsa030180.96847619
59Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.93991746
60RNA polymerase_Homo sapiens_hsa030200.93831451
61Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.93193022
62Ether lipid metabolism_Homo sapiens_hsa005650.93013258
63Adherens junction_Homo sapiens_hsa045200.92549292
64Glioma_Homo sapiens_hsa052140.87760040
65Oxidative phosphorylation_Homo sapiens_hsa001900.87521255
66Rheumatoid arthritis_Homo sapiens_hsa053230.87422376
67Melanoma_Homo sapiens_hsa052180.87281171
68Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.85409158
69Ras signaling pathway_Homo sapiens_hsa040140.84998160
70Dorso-ventral axis formation_Homo sapiens_hsa043200.84362240
71Dilated cardiomyopathy_Homo sapiens_hsa054140.82976208
72Hedgehog signaling pathway_Homo sapiens_hsa043400.82491321
73Circadian rhythm_Homo sapiens_hsa047100.81937982
74cGMP-PKG signaling pathway_Homo sapiens_hsa040220.81383629
75Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.79770459
76MAPK signaling pathway_Homo sapiens_hsa040100.79659626
77Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.79153927
78Homologous recombination_Homo sapiens_hsa034400.78908808
79Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.78885069
80Estrogen signaling pathway_Homo sapiens_hsa049150.77106009
81Cardiac muscle contraction_Homo sapiens_hsa042600.77020129
82Basal cell carcinoma_Homo sapiens_hsa052170.74098263
83Choline metabolism in cancer_Homo sapiens_hsa052310.73871188
84Vascular smooth muscle contraction_Homo sapiens_hsa042700.72742057
85Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.70842094
86Maturity onset diabetes of the young_Homo sapiens_hsa049500.70588506
87Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.70529989
88Protein digestion and absorption_Homo sapiens_hsa049740.68841527
89Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.68117091
90Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.67271594
91Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67210508
92Alzheimers disease_Homo sapiens_hsa050100.67040192
93Fatty acid metabolism_Homo sapiens_hsa012120.66624796
94Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.66466131
95* MicroRNAs in cancer_Homo sapiens_hsa052060.64918819
96Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.64514175
97Rap1 signaling pathway_Homo sapiens_hsa040150.64200745
98Type II diabetes mellitus_Homo sapiens_hsa049300.63584030
99RNA transport_Homo sapiens_hsa030130.63491306
100African trypanosomiasis_Homo sapiens_hsa051430.61961048
101Hippo signaling pathway_Homo sapiens_hsa043900.61358018
102mRNA surveillance pathway_Homo sapiens_hsa030150.60069784
103Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.59094411
104Ovarian steroidogenesis_Homo sapiens_hsa049130.58721516
105Alcoholism_Homo sapiens_hsa050340.58519529
106beta-Alanine metabolism_Homo sapiens_hsa004100.58461329
107Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.58162667
108Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.57069876
109Cysteine and methionine metabolism_Homo sapiens_hsa002700.56702165
110Primary bile acid biosynthesis_Homo sapiens_hsa001200.56481237
111Focal adhesion_Homo sapiens_hsa045100.55496278
112Colorectal cancer_Homo sapiens_hsa052100.55065525
113Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54473647
114Phagosome_Homo sapiens_hsa041450.54373909
115Nitrogen metabolism_Homo sapiens_hsa009100.54274076
116Phospholipase D signaling pathway_Homo sapiens_hsa040720.53654111
117Cell cycle_Homo sapiens_hsa041100.53226450
118Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51455531
119Tryptophan metabolism_Homo sapiens_hsa003800.49603675
120Type I diabetes mellitus_Homo sapiens_hsa049400.49473460
121Sphingolipid metabolism_Homo sapiens_hsa006000.47839229
122Endometrial cancer_Homo sapiens_hsa052130.46861332
123Oocyte meiosis_Homo sapiens_hsa041140.46173227
124Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.45458030
125TGF-beta signaling pathway_Homo sapiens_hsa043500.45237768
126Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43278931
127Renal cell carcinoma_Homo sapiens_hsa052110.42579852
128Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.41648133
129Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.40497398
130Parkinsons disease_Homo sapiens_hsa050120.39672688
131Mineral absorption_Homo sapiens_hsa049780.38378106
132Huntingtons disease_Homo sapiens_hsa050160.37692662
133Pancreatic secretion_Homo sapiens_hsa049720.36981909
134Sphingolipid signaling pathway_Homo sapiens_hsa040710.36360850
135ECM-receptor interaction_Homo sapiens_hsa045120.34296529
136Thyroid hormone signaling pathway_Homo sapiens_hsa049190.33409850
137Regulation of actin cytoskeleton_Homo sapiens_hsa048100.32679970
138Thyroid hormone synthesis_Homo sapiens_hsa049180.32013235
139PI3K-Akt signaling pathway_Homo sapiens_hsa041510.31776560
140Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30987226
141Neurotrophin signaling pathway_Homo sapiens_hsa047220.28585977

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