MMEL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the neutral endopeptidase (NEP) or membrane metallo-endopeptidase (MME) family. Family members play important roles in pain perception, arterial pressure regulation, phosphate metabolism and homeostasis. This protein is a type II transmembrane protein and is thought to be expressed as a secreted protein. This gene is expressed mainly in testis with weak expression in the brain, kidney, and heart. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome reaction (GO:0007340)7.51521794
2axonemal dynein complex assembly (GO:0070286)7.21494860
3cilium or flagellum-dependent cell motility (GO:0001539)7.12724170
4sperm motility (GO:0030317)6.73447865
5motile cilium assembly (GO:0044458)6.73185099
6response to pheromone (GO:0019236)6.72871539
7epithelial cilium movement (GO:0003351)6.58270623
8multicellular organism reproduction (GO:0032504)6.52637209
9fusion of sperm to egg plasma membrane (GO:0007342)6.43694747
10cilium movement (GO:0003341)5.99421186
11cell wall macromolecule catabolic process (GO:0016998)5.73818572
12cell wall macromolecule metabolic process (GO:0044036)5.73818572
13acrosome assembly (GO:0001675)5.52026324
14sperm-egg recognition (GO:0035036)5.46990498
15axon ensheathment in central nervous system (GO:0032291)5.42955691
16central nervous system myelination (GO:0022010)5.42955691
17epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.27201988
18reproduction (GO:0000003)5.11646879
19plasma membrane fusion (GO:0045026)4.89327357
20cell-cell recognition (GO:0009988)4.78154247
21regulation of cilium movement (GO:0003352)4.74990664
22binding of sperm to zona pellucida (GO:0007339)4.73137031
23regulation of mitochondrial translation (GO:0070129)4.70136315
24centriole assembly (GO:0098534)4.60257872
25rRNA modification (GO:0000154)4.59414014
26microtubule depolymerization (GO:0007019)4.58898993
27ventricular system development (GO:0021591)4.50910194
28spermatid development (GO:0007286)4.49303128
29protein polyglutamylation (GO:0018095)4.41958940
30single fertilization (GO:0007338)4.40630683
31rRNA methylation (GO:0031167)4.23759167
32piRNA metabolic process (GO:0034587)4.19204868
33mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.92560125
34seminiferous tubule development (GO:0072520)3.90639194
35sperm capacitation (GO:0048240)3.73977665
36regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.73353762
37male meiosis (GO:0007140)3.69028200
38protein localization to cilium (GO:0061512)3.68783988
39single strand break repair (GO:0000012)3.68683497
40DNA ligation (GO:0006266)3.68298419
41cellular ketone body metabolic process (GO:0046950)3.62868000
42regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.58889994
43fertilization (GO:0009566)3.57423232
44mitochondrial calcium ion transport (GO:0006851)3.54461984
45DNA methylation involved in gamete generation (GO:0043046)3.51105894
46centriole replication (GO:0007099)3.46475501
47viral transcription (GO:0019083)3.45379660
48DNA packaging (GO:0006323)3.45159819
49chromosome condensation (GO:0030261)3.42297669
50calcium ion-dependent exocytosis (GO:0017156)3.40922352
51ketone body metabolic process (GO:1902224)3.39674575
52glycerol ether metabolic process (GO:0006662)3.36149177
53presynaptic membrane assembly (GO:0097105)3.35688403
54fat-soluble vitamin biosynthetic process (GO:0042362)3.34870325
55cofactor catabolic process (GO:0051187)3.34564112
56tachykinin receptor signaling pathway (GO:0007217)3.34229640
57glyoxylate metabolic process (GO:0046487)3.32087783
58keratinocyte development (GO:0003334)3.31610408
59spermatogenesis (GO:0007283)3.30345435
60left/right axis specification (GO:0070986)3.29273399
61male gamete generation (GO:0048232)3.28888303
62sexual reproduction (GO:0019953)3.26185390
63meiosis I (GO:0007127)3.26119792
64RNA destabilization (GO:0050779)3.24320468
65coenzyme catabolic process (GO:0009109)3.23992610
66cilium assembly (GO:0042384)3.23073022
67quinone biosynthetic process (GO:1901663)3.19613700
68presynaptic membrane organization (GO:0097090)3.18010413
69cilium organization (GO:0044782)3.16015752
70glutathione derivative metabolic process (GO:1901685)3.15413184
71glutathione derivative biosynthetic process (GO:1901687)3.15413184
72translational termination (GO:0006415)3.14538731
73polyol transport (GO:0015791)3.13303481
74limb bud formation (GO:0060174)3.12240077
75intraciliary transport (GO:0042073)3.10695573
76negative regulation of cardiac muscle hypertrophy (GO:0010614)3.10324515
77female gonad development (GO:0008585)3.07549902
78gamete generation (GO:0007276)3.05097557
79male meiosis I (GO:0007141)3.04096107
80microtubule polymerization or depolymerization (GO:0031109)3.03400889
81ether metabolic process (GO:0018904)3.03313302
82long-chain fatty acid biosynthetic process (GO:0042759)3.02742089
83purine ribonucleotide transport (GO:0015868)3.01088704
84negative regulation of telomere maintenance (GO:0032205)3.00680140
85regulation of inclusion body assembly (GO:0090083)3.00062400
86cranial nerve morphogenesis (GO:0021602)2.99346865
87peroxisome fission (GO:0016559)2.97754694
88axoneme assembly (GO:0035082)2.97560095
89ATP synthesis coupled proton transport (GO:0015986)2.97111236
90energy coupled proton transport, down electrochemical gradient (GO:0015985)2.97111236
91inner mitochondrial membrane organization (GO:0007007)2.96807831
92cell recognition (GO:0008037)2.96313953
93regulation of activation of Janus kinase activity (GO:0010533)2.96148014
94positive regulation of uterine smooth muscle contraction (GO:0070474)2.94838041
95NADH metabolic process (GO:0006734)2.94834853
96ubiquinone biosynthetic process (GO:0006744)2.94665851
97negative regulation of transcription regulatory region DNA binding (GO:2000678)2.94644016
98translational elongation (GO:0006414)2.93815989
99chaperone-mediated protein transport (GO:0072321)2.90295252
100organic cation transport (GO:0015695)2.88935533
101sulfur amino acid catabolic process (GO:0000098)2.88250651
102phosphatidylethanolamine biosynthetic process (GO:0006646)2.85983684
103ribosomal small subunit assembly (GO:0000028)2.85701797
104neuron cell-cell adhesion (GO:0007158)2.82947129
105negative regulation of inclusion body assembly (GO:0090084)2.82014247
106negative regulation of muscle hypertrophy (GO:0014741)2.81754751
107ubiquinone metabolic process (GO:0006743)2.80986250
108mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.79895998
109superoxide anion generation (GO:0042554)2.79474618
110mesonephros development (GO:0001823)2.79356025
111grooming behavior (GO:0007625)2.79091402
112synaptonemal complex organization (GO:0070193)2.77433536
113phenylpropanoid metabolic process (GO:0009698)2.75319836
114adenosine metabolic process (GO:0046085)2.75260074
115response to X-ray (GO:0010165)2.75013848
116cellular component assembly involved in morphogenesis (GO:0010927)2.74946398
117angiotensin maturation (GO:0002003)2.74421959
118regulation of guanylate cyclase activity (GO:0031282)2.73216899
119alkaloid metabolic process (GO:0009820)2.72340220
120epoxygenase P450 pathway (GO:0019373)2.72150853
121retina layer formation (GO:0010842)2.71884855
122limb development (GO:0060173)2.71810510
123appendage development (GO:0048736)2.71810510
124positive regulation of protein kinase C signaling (GO:0090037)2.71021798
125histone H2B ubiquitination (GO:0033523)2.70582508
126spermatid nucleus differentiation (GO:0007289)2.69891861
127respiratory electron transport chain (GO:0022904)2.69138035
128electron transport chain (GO:0022900)2.69021913
129phenol-containing compound catabolic process (GO:0019336)2.68064373
130vitamin biosynthetic process (GO:0009110)2.67588352
131androgen biosynthetic process (GO:0006702)2.67170754
132startle response (GO:0001964)2.66692639
133positive regulation of amino acid transport (GO:0051957)2.66615723
134regulation of actin nucleation (GO:0051125)2.65667985
135cellular protein complex disassembly (GO:0043624)2.64757802
136GTP biosynthetic process (GO:0006183)2.64117248
137peptidyl-arginine omega-N-methylation (GO:0035247)2.63004920
138positive regulation of lipoprotein lipase activity (GO:0051006)2.60880747
139positive regulation of triglyceride lipase activity (GO:0061365)2.60880747
140hormone catabolic process (GO:0042447)2.60242204
141urogenital system development (GO:0001655)2.59938861
142SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.59891794
143glutathione metabolic process (GO:0006749)2.59627593
144positive regulation of cellular amine metabolic process (GO:0033240)2.59253350
145xenobiotic catabolic process (GO:0042178)2.58786585
146establishment of protein localization to mitochondrial membrane (GO:0090151)2.58275990
147synaptonemal complex assembly (GO:0007130)2.58158077
148rRNA catabolic process (GO:0016075)2.57717223
149germ cell development (GO:0007281)2.55005144
150synapsis (GO:0007129)2.53215982
151cellular process involved in reproduction in multicellular organism (GO:0022412)2.50932213
152cilium morphogenesis (GO:0060271)2.48919000
153positive regulation of icosanoid secretion (GO:0032305)2.46562391
154regulation of transmission of nerve impulse (GO:0051969)2.45779265
155positive regulation of action potential (GO:0045760)2.45440436
156preassembly of GPI anchor in ER membrane (GO:0016254)2.43464364
157protein K63-linked deubiquitination (GO:0070536)2.42241938
158spinal cord motor neuron differentiation (GO:0021522)2.42132714
159regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.41708621
160left/right pattern formation (GO:0060972)2.41207546
161negative regulation of protein localization to cell surface (GO:2000009)2.40514854
162chromosome organization involved in meiosis (GO:0070192)2.40228987
163cell proliferation in forebrain (GO:0021846)2.38502091
164GPI anchor biosynthetic process (GO:0006506)2.36752176
165multicellular organismal reproductive process (GO:0048609)2.35578853
166developmental pigmentation (GO:0048066)2.35235838
167nucleoside diphosphate phosphorylation (GO:0006165)2.35065259
168positive regulation of organic acid transport (GO:0032892)2.34672056
169regulation of microtubule-based movement (GO:0060632)2.33080042
170calcium ion import (GO:0070509)2.32942925

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.27164192
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.50612259
3EZH2_22144423_ChIP-Seq_EOC_Human4.07436322
4GBX2_23144817_ChIP-Seq_PC3_Human3.65149983
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.62580731
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.95642564
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.79463044
8MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.65804276
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.64369956
10TAF15_26573619_Chip-Seq_HEK293_Human2.60864367
11PCGF2_27294783_Chip-Seq_ESCs_Mouse2.51610894
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.38341682
13CBX2_27304074_Chip-Seq_ESCs_Mouse2.30191124
14YY1_22570637_ChIP-Seq_MALME-3M_Human2.25722595
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.23870307
16PCGF2_27294783_Chip-Seq_NPCs_Mouse2.19372729
17BMI1_23680149_ChIP-Seq_NPCS_Mouse2.17793837
18VDR_22108803_ChIP-Seq_LS180_Human2.16469836
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.15687963
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.13134429
21BCL6_27268052_Chip-Seq_Bcells_Human2.10672830
22SUZ12_27294783_Chip-Seq_NPCs_Mouse2.06758934
23RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.99225354
24NFE2_27457419_Chip-Seq_LIVER_Mouse1.97494259
25* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.91911739
26TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.87794213
27NANOG_18555785_Chip-Seq_ESCs_Mouse1.85372622
28EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.81679027
29YY1_21170310_ChIP-Seq_MESCs_Mouse1.80236835
30RNF2_27304074_Chip-Seq_NSC_Mouse1.79573611
31ERA_21632823_ChIP-Seq_H3396_Human1.78165473
32SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.75843486
33KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.75649351
34BCOR_27268052_Chip-Seq_Bcells_Human1.73769260
35EZH2_27304074_Chip-Seq_ESCs_Mouse1.72714976
36JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.72660521
37EZH2_27294783_Chip-Seq_NPCs_Mouse1.72600405
38SUZ12_18555785_Chip-Seq_ESCs_Mouse1.72590095
39P53_22387025_ChIP-Seq_ESCs_Mouse1.72341291
40* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.71914796
41NANOG_20526341_ChIP-Seq_ESCs_Human1.71072036
42POU3F2_20337985_ChIP-ChIP_501MEL_Human1.70335364
43JARID2_20064375_ChIP-Seq_MESCs_Mouse1.69854461
44EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.67322708
45ERG_20517297_ChIP-Seq_VCAP_Human1.66804570
46E2F1_18555785_Chip-Seq_ESCs_Mouse1.65097768
47* PHF8_20622854_ChIP-Seq_HELA_Human1.64634728
48CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.64582349
49STAT3_18555785_Chip-Seq_ESCs_Mouse1.62459399
50P300_19829295_ChIP-Seq_ESCs_Human1.62413674
51P300_18555785_Chip-Seq_ESCs_Mouse1.62209418
52* CTCF_27219007_Chip-Seq_Bcells_Human1.60782250
53FUS_26573619_Chip-Seq_HEK293_Human1.60204689
54* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.59497185
55EZH2_27294783_Chip-Seq_ESCs_Mouse1.58894446
56CMYC_18555785_Chip-Seq_ESCs_Mouse1.57975657
57SRY_22984422_ChIP-ChIP_TESTIS_Rat1.57108430
58CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.56598439
59CTCF_20526341_ChIP-Seq_ESCs_Human1.54913173
60ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.54886685
61EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.54573733
62SOX2_22085726_ChIP-Seq_NPCs_Mouse1.53476480
63* SA1_27219007_Chip-Seq_Bcells_Human1.51504388
64EED_16625203_ChIP-ChIP_MESCs_Mouse1.50553975
65SUZ12_27294783_Chip-Seq_ESCs_Mouse1.49909390
66OCT4_18555785_Chip-Seq_ESCs_Mouse1.49561829
67ELF1_20517297_ChIP-Seq_JURKAT_Human1.49319531
68E2F1_20622854_ChIP-Seq_HELA_Human1.49234861
69SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.49194027
70RAC3_21632823_ChIP-Seq_H3396_Human1.49170112
71TAL1_26923725_Chip-Seq_HPCs_Mouse1.49011213
72NMYC_18555785_Chip-Seq_ESCs_Mouse1.47971204
73KLF4_18555785_Chip-Seq_ESCs_Mouse1.47408244
74PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.46931294
75GABP_17652178_ChIP-ChIP_JURKAT_Human1.46368200
76LXR_22292898_ChIP-Seq_THP-1_Human1.45584255
77ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.45056553
78SOX2_18555785_Chip-Seq_ESCs_Mouse1.44847098
79TET1_21451524_ChIP-Seq_MESCs_Mouse1.44697109
80RUNX1_27457419_Chip-Seq_LIVER_Mouse1.43844100
81KDM2B_26808549_Chip-Seq_REH_Human1.43457502
82SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.43205587
83MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.42956554
84JARID2_20075857_ChIP-Seq_MESCs_Mouse1.42317873
85SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.41625974
86* SA1_27219007_Chip-Seq_ERYTHROID_Human1.41518516
87* P68_20966046_ChIP-Seq_HELA_Human1.41405660
88SMAD3_21741376_ChIP-Seq_EPCs_Human1.41093695
89SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.40834285
90IKZF1_21737484_ChIP-ChIP_HCT116_Human1.40819779
91PU1_27457419_Chip-Seq_LIVER_Mouse1.40677955
92KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.40487165
93SMAD4_21799915_ChIP-Seq_A2780_Human1.40311746
94POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.39929715
95TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39929715
96OCT4_20526341_ChIP-Seq_ESCs_Human1.39236513
97ESRRB_18555785_Chip-Seq_ESCs_Mouse1.39149052
98PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.38995948
99CRX_20693478_ChIP-Seq_RETINA_Mouse1.38711968
100ER_23166858_ChIP-Seq_MCF-7_Human1.38573039
101* P300_27268052_Chip-Seq_Bcells_Human1.38248377
102MYC_18555785_ChIP-Seq_MESCs_Mouse1.38065050
103HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.37584756
104TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36780245
105REST_21632747_ChIP-Seq_MESCs_Mouse1.36375370
106ZFX_18555785_Chip-Seq_ESCs_Mouse1.36112506
107TAF2_19829295_ChIP-Seq_ESCs_Human1.35927246
108CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.34801217
109MYC_19829295_ChIP-Seq_ESCs_Human1.34563547
110PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.33686981
111CTCF_18555785_Chip-Seq_ESCs_Mouse1.33657266
112SMAD1_18555785_Chip-Seq_ESCs_Mouse1.31824192
113ZNF274_21170338_ChIP-Seq_K562_Hela1.31753076
114CTCF_21964334_Chip-Seq_Bcells_Human1.31642726
115SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.31174240
116FOXP1_21924763_ChIP-Seq_HESCs_Human1.31171266
117EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.31100450
118OCT4_21477851_ChIP-Seq_ESCs_Mouse1.30884984
119RNF2_27304074_Chip-Seq_ESCs_Mouse1.30481059
120RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.29544800
121RNF2_18974828_ChIP-Seq_MESCs_Mouse1.29513105
122EZH2_18974828_ChIP-Seq_MESCs_Mouse1.29513105
123SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.29425425
124ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.29335069
125SOX2_21211035_ChIP-Seq_LN229_Human1.28388256
126TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25872293
127MYC_18358816_ChIP-ChIP_MESCs_Mouse1.25308146
128STAT1_20625510_ChIP-Seq_HELA_Human1.24980327
129MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.24957978
130HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.24656500
131UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24576831
132CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.23694798
133EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.23676075
134GATA3_21867929_ChIP-Seq_CD8_Mouse1.22375946
135EST1_17652178_ChIP-ChIP_JURKAT_Human1.22366799
136RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.21074754
137MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.20947104
138MTF2_20144788_ChIP-Seq_MESCs_Mouse1.20916802
139CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20912032
140NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.18961511
141FOXA1_25329375_ChIP-Seq_VCAP_Human1.18831474
142FOXA1_27270436_Chip-Seq_PROSTATE_Human1.18831474
143PIAS1_25552417_ChIP-Seq_VCAP_Human1.18641579
144NCOR_22424771_ChIP-Seq_293T_Human1.18122397
145CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.17485306
146CTCF_18555785_ChIP-Seq_MESCs_Mouse1.17081914
147WDR5_24793694_ChIP-Seq_LNCAP_Human1.16914573
148SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.15897279
149AR_20517297_ChIP-Seq_VCAP_Human1.15704177
150SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.15200160
151SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.14854745
152* SMC4_20622854_ChIP-Seq_HELA_Human1.14722885
153CDX2_19796622_ChIP-Seq_MESCs_Mouse1.12371807
154TCF4_23295773_ChIP-Seq_U87_Human1.11132493
155IRF1_19129219_ChIP-ChIP_H3396_Human1.10853839
156FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.10668810
157ETS1_20019798_ChIP-Seq_JURKAT_Human1.10652448
158CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.10221331
159P53_21459846_ChIP-Seq_SAOS-2_Human1.10006288
160E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.09383861
161AUTS2_25519132_ChIP-Seq_293T-REX_Human1.09087815
162RAD21_21589869_ChIP-Seq_MESCs_Mouse1.08962938
163ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.08827359
164CREB1_15753290_ChIP-ChIP_HEK293T_Human1.08357923
165TDRD3_21172665_ChIP-Seq_MCF-7_Human1.07885720
166SPI1_20517297_ChIP-Seq_HL60_Human1.07214574
167GATA1_26923725_Chip-Seq_HPCs_Mouse1.06499372
168CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.05924271
169RUNX2_22187159_ChIP-Seq_PCA_Human1.05683032
170STAT6_21828071_ChIP-Seq_BEAS2B_Human1.05471185
171STAT1_17558387_ChIP-Seq_HELA_Human1.05293412
172* P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.05178281
173GATA3_21878914_ChIP-Seq_MCF-7_Human1.04400071
174GF1_26923725_Chip-Seq_HPCs_Mouse1.04103295
175PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.03944487
176* STAT3_23295773_ChIP-Seq_U87_Human1.03721034
177XRN2_22483619_ChIP-Seq_HELA_Human1.01429652
178VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.98649818
179TP63_22573176_ChIP-Seq_HFKS_Human0.97609821
180IGF1R_20145208_ChIP-Seq_DFB_Human0.96277739
181SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.94666500
182TTF2_22483619_ChIP-Seq_HELA_Human0.93581969
183CSB_26484114_Chip-Seq_FIBROBLAST_Human0.92902624
184IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.92833977
185CBP_20019798_ChIP-Seq_JUKART_Human0.92833977
186FOXH1_21741376_ChIP-Seq_ESCs_Human0.92677500
187CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.91800283
188ELF1_17652178_ChIP-ChIP_JURKAT_Human0.91747714
189SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91316358
190POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.89339598
191CEBPB_22108803_ChIP-Seq_LS180_Human0.88507062
192SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.87142856
193HTT_18923047_ChIP-ChIP_STHdh_Human0.86401026
194SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.86040745

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0005410_abnormal_fertilization6.72393034
2MP0005360_urolithiasis3.82445133
3MP0001188_hyperpigmentation3.55677123
4MP0006292_abnormal_olfactory_placode3.16742805
5MP0003136_yellow_coat_color3.02560710
6MP0002132_abnormal_respiratory_system2.87454085
7MP0002102_abnormal_ear_morphology2.81324295
8MP0005085_abnormal_gallbladder_physiolo2.72207708
9* MP0003698_abnormal_male_reproductive2.66909574
10MP0002138_abnormal_hepatobiliary_system2.62245697
11MP0005365_abnormal_bile_salt2.48631667
12MP0005409_darkened_coat_color2.44270821
13MP0002653_abnormal_ependyma_morphology2.41196093
14MP0000372_irregular_coat_pigmentation2.36745333
15MP0008877_abnormal_DNA_methylation2.30728518
16MP0002139_abnormal_hepatobiliary_system2.26734550
17MP0001929_abnormal_gametogenesis2.21570891
18MP0003183_abnormal_peptide_metabolism2.13905412
19MP0003880_abnormal_central_pattern2.12262880
20MP0004742_abnormal_vestibular_system2.10015756
21MP0003718_maternal_effect1.98649469
22MP0001486_abnormal_startle_reflex1.98380679
23MP0003806_abnormal_nucleotide_metabolis1.97887609
24MP0003787_abnormal_imprinting1.95400402
25MP0001666_abnormal_nutrient_absorption1.95235545
26MP0008875_abnormal_xenobiotic_pharmacok1.94556355
27MP0000678_abnormal_parathyroid_gland1.92838825
28MP0003011_delayed_dark_adaptation1.87918613
29MP0004381_abnormal_hair_follicle1.87735170
30MP0004019_abnormal_vitamin_homeostasis1.84487170
31MP0000566_synostosis1.81682671
32MP0003941_abnormal_skin_development1.80257659
33MP0005171_absent_coat_pigmentation1.74961324
34MP0002277_abnormal_respiratory_mucosa1.74721568
35MP0005423_abnormal_somatic_nervous1.68411106
36MP0005451_abnormal_body_composition1.67532714
37MP0000026_abnormal_inner_ear1.65860086
38MP0002160_abnormal_reproductive_system1.64513531
39MP0006276_abnormal_autonomic_nervous1.61691564
40MP0005645_abnormal_hypothalamus_physiol1.58833682
41MP0005253_abnormal_eye_physiology1.57293783
42MP0001963_abnormal_hearing_physiology1.56185090
43MP0009745_abnormal_behavioral_response1.54827242
44MP0009046_muscle_twitch1.49974929
45MP0001727_abnormal_embryo_implantation1.49739666
46MP0006072_abnormal_retinal_apoptosis1.49269936
47MP0005551_abnormal_eye_electrophysiolog1.49067656
48MP0005670_abnormal_white_adipose1.48982605
49MP0002272_abnormal_nervous_system1.47931319
50MP0002210_abnormal_sex_determination1.47730500
51MP0001529_abnormal_vocalization1.47131614
52MP0003950_abnormal_plasma_membrane1.46327586
53MP0005379_endocrine/exocrine_gland_phen1.45233944
54MP0001764_abnormal_homeostasis1.43818602
55MP0002751_abnormal_autonomic_nervous1.42854711
56MP0001984_abnormal_olfaction1.39849964
57MP0009840_abnormal_foam_cell1.38419349
58MP0000015_abnormal_ear_pigmentation1.36792719
59MP0009697_abnormal_copulation1.32952693
60MP0005646_abnormal_pituitary_gland1.30830918
61* MP0002161_abnormal_fertility/fecundity1.29854541
62MP0008789_abnormal_olfactory_epithelium1.29290719
63MP0002572_abnormal_emotion/affect_behav1.28422968
64MP0000778_abnormal_nervous_system1.27524413
65MP0000049_abnormal_middle_ear1.26862150
66MP0001905_abnormal_dopamine_level1.26774317
67MP0005636_abnormal_mineral_homeostasis1.23763269
68MP0002638_abnormal_pupillary_reflex1.23547814
69MP0001485_abnormal_pinna_reflex1.22198530
70MP0005394_taste/olfaction_phenotype1.21843166
71MP0005499_abnormal_olfactory_system1.21843166
72MP0000383_abnormal_hair_follicle1.21198037
73MP0004270_analgesia1.18411387
74MP0008058_abnormal_DNA_repair1.17931396
75MP0002752_abnormal_somatic_nervous1.17437727
76MP0005389_reproductive_system_phenotype1.16781264
77MP0010386_abnormal_urinary_bladder1.16752733
78MP0002557_abnormal_social/conspecific_i1.16600751
79MP0009379_abnormal_foot_pigmentation1.16083996
80MP0001986_abnormal_taste_sensitivity1.16041563
81MP0005083_abnormal_biliary_tract1.15055037
82MP0001145_abnormal_male_reproductive1.13348270
83MP0000920_abnormal_myelination1.12100352
84MP0002938_white_spotting1.11210380
85MP0002876_abnormal_thyroid_physiology1.10785485
86MP0002735_abnormal_chemical_nociception1.10356363
87MP0001968_abnormal_touch/_nociception1.09617972
88MP0002067_abnormal_sensory_capabilities1.09314888
89MP0002064_seizures1.08723392
90MP0001440_abnormal_grooming_behavior1.08130063
91MP0003638_abnormal_response/metabolism_1.06568345
92MP0003635_abnormal_synaptic_transmissio1.05457730
93MP0000762_abnormal_tongue_morphology1.05384702
94MP0005174_abnormal_tail_pigmentation1.05351244
95MP0000653_abnormal_sex_gland1.05245380
96MP0004142_abnormal_muscle_tone1.04952555
97MP0005332_abnormal_amino_acid1.03547074
98MP0002734_abnormal_mechanical_nocicepti1.03423892
99MP0000631_abnormal_neuroendocrine_gland1.03343435
100MP0003879_abnormal_hair_cell1.01824904
101MP0003938_abnormal_ear_development1.01459145
102MP0002184_abnormal_innervation0.99650398
103MP0002249_abnormal_larynx_morphology0.99357244
104MP0005084_abnormal_gallbladder_morpholo0.99267256
105MP0005187_abnormal_penis_morphology0.95982384
106MP0001664_abnormal_digestion0.95842674
107MP0008995_early_reproductive_senescence0.95765650
108MP0002736_abnormal_nociception_after0.95735984
109MP0000462_abnormal_digestive_system0.95204692
110MP0009250_abnormal_appendicular_skeleto0.94105424
111MP0002733_abnormal_thermal_nociception0.92265377
112MP0002822_catalepsy0.92155704
113MP0005377_hearing/vestibular/ear_phenot0.92021641
114MP0003878_abnormal_ear_physiology0.92021641
115MP0002063_abnormal_learning/memory/cond0.91259216
116MP0004133_heterotaxia0.90311732
117MP0001765_abnormal_ion_homeostasis0.89262172
118MP0001293_anophthalmia0.88465138
119MP0003937_abnormal_limbs/digits/tail_de0.88130657
120MP0002882_abnormal_neuron_morphology0.84553435
121MP0005391_vision/eye_phenotype0.84219721
122MP0004264_abnormal_extraembryonic_tissu0.83992330
123MP0002282_abnormal_trachea_morphology0.83574353
124MP0003252_abnormal_bile_duct0.83313178
125MP0000613_abnormal_salivary_gland0.83075824
126MP0001919_abnormal_reproductive_system0.83002798
127MP0005248_abnormal_Harderian_gland0.82321668
128MP0002234_abnormal_pharynx_morphology0.82000197
129MP0002229_neurodegeneration0.81267672
130MP0009643_abnormal_urine_homeostasis0.78802446
131MP0010329_abnormal_lipoprotein_level0.78439415
132MP0003186_abnormal_redox_activity0.78202695
133MP0006036_abnormal_mitochondrial_physio0.77535141
134MP0000490_abnormal_crypts_of0.77311231
135MP0000579_abnormal_nail_morphology0.75139326
136MP0005647_abnormal_sex_gland0.74969276
137MP0003868_abnormal_feces_composition0.74236022
138MP0003646_muscle_fatigue0.72721526
139MP0005075_abnormal_melanosome_morpholog0.72476408
140MP0005310_abnormal_salivary_gland0.72069371
141MP0008057_abnormal_DNA_replication0.71491918
142MP0002177_abnormal_outer_ear0.70857094
143MP0000955_abnormal_spinal_cord0.69792496
144MP0003191_abnormal_cellular_cholesterol0.69401509
145MP0005195_abnormal_posterior_eye0.68860083
146MP0000538_abnormal_urinary_bladder0.68577436
147MP0003693_abnormal_embryo_hatching0.67875706
148MP0005165_increased_susceptibility_to0.67754385
149MP0005058_abnormal_lysosome_morphology0.63091242
150MP0002118_abnormal_lipid_homeostasis0.60967168
151MP0000604_amyloidosis0.60735626
152MP0005584_abnormal_enzyme/coenzyme_acti0.59359635
153MP0005319_abnormal_enzyme/_coenzyme0.57861507
154MP0003315_abnormal_perineum_morphology0.57769085
155MP0006035_abnormal_mitochondrial_morpho0.56984719

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)8.36278000
2Absent/shortened dynein arms (HP:0200106)8.36278000
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.29860402
4Abnormal respiratory epithelium morphology (HP:0012253)6.33492971
5Abnormal respiratory motile cilium morphology (HP:0005938)6.33492971
6Abnormal respiratory motile cilium physiology (HP:0012261)6.13987965
7Abnormal ciliary motility (HP:0012262)5.85518043
8Duplicated collecting system (HP:0000081)4.65247515
9Chromosomal breakage induced by crosslinking agents (HP:0003221)4.62242244
10Rhinitis (HP:0012384)4.21639533
11Abnormality of the renal collecting system (HP:0004742)4.10961013
12Chromsome breakage (HP:0040012)3.87789028
13Nephronophthisis (HP:0000090)3.84461721
14Upper limb muscle weakness (HP:0003484)3.59122019
15Reduced antithrombin III activity (HP:0001976)3.28287198
16Bony spicule pigmentary retinopathy (HP:0007737)3.16712173
17Abnormality of the renal medulla (HP:0100957)3.14623670
18Hyperglycinuria (HP:0003108)3.12852686
19Chronic bronchitis (HP:0004469)3.12251235
20Petechiae (HP:0000967)3.10297917
21Acute encephalopathy (HP:0006846)3.09918231
22Severe visual impairment (HP:0001141)2.97625038
23Abnormality of DNA repair (HP:0003254)2.95514608
24Septo-optic dysplasia (HP:0100842)2.90588779
25Papilledema (HP:0001085)2.90185583
26Abnormality of serine family amino acid metabolism (HP:0010894)2.86054169
27Abnormality of glycine metabolism (HP:0010895)2.86054169
28Renal Fanconi syndrome (HP:0001994)2.76505145
29Medial flaring of the eyebrow (HP:0010747)2.76166089
30Tubulointerstitial nephritis (HP:0001970)2.72982000
31Type II lissencephaly (HP:0007260)2.71491076
32Abnormality of glutamine family amino acid metabolism (HP:0010902)2.68503879
33Glycosuria (HP:0003076)2.68280854
34Abnormality of urine glucose concentration (HP:0011016)2.68280854
35Azoospermia (HP:0000027)2.67450416
36Bronchiectasis (HP:0002110)2.67174072
37Duplication of thumb phalanx (HP:0009942)2.65342134
38Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.59164317
39Acute necrotizing encephalopathy (HP:0006965)2.59058755
40Abnormal rod and cone electroretinograms (HP:0008323)2.58470547
41Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.58097503
42Increased hepatocellular lipid droplets (HP:0006565)2.57580606
43Congenital sensorineural hearing impairment (HP:0008527)2.56414508
44Delayed CNS myelination (HP:0002188)2.54871281
45Flat capital femoral epiphysis (HP:0003370)2.52465443
46Abnormal mitochondria in muscle tissue (HP:0008316)2.50799167
47Hyperphosphaturia (HP:0003109)2.48021030
48Degeneration of the lateral corticospinal tracts (HP:0002314)2.47146269
49Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.47146269
50Lipid accumulation in hepatocytes (HP:0006561)2.43467260
51Infertility (HP:0000789)2.41561677
52Increased purine levels (HP:0004368)2.40646926
53Hyperuricemia (HP:0002149)2.40646926
54Mitochondrial inheritance (HP:0001427)2.39836692
55Recurrent sinusitis (HP:0011108)2.36523501
56Abnormal spermatogenesis (HP:0008669)2.36305939
57Decreased central vision (HP:0007663)2.33937959
58Respiratory difficulties (HP:0002880)2.31308176
59Concave nail (HP:0001598)2.31171565
60Testicular atrophy (HP:0000029)2.28135541
61Abnormal gallbladder physiology (HP:0012438)2.27043555
62Cholecystitis (HP:0001082)2.27043555
63Aplastic anemia (HP:0001915)2.26410732
64Generalized aminoaciduria (HP:0002909)2.25463135
65Potter facies (HP:0002009)2.25395943
66Facial shape deformation (HP:0011334)2.25395943
67Optic nerve hypoplasia (HP:0000609)2.23155118
68Abnormal number of erythroid precursors (HP:0012131)2.23148030
69Prostate neoplasm (HP:0100787)2.23146057
70Rib fusion (HP:0000902)2.22870247
71Abnormality of monocarboxylic acid metabolism (HP:0010996)2.19931114
72Postaxial foot polydactyly (HP:0001830)2.19687857
73Absent septum pellucidum (HP:0001331)2.19310819
743-Methylglutaconic aciduria (HP:0003535)2.14870977
75Abnormality of purine metabolism (HP:0004352)2.13112653
76Atelectasis (HP:0100750)2.12837209
77Increased intramyocellular lipid droplets (HP:0012240)2.11317561
78Abnormality of nucleobase metabolism (HP:0010932)2.10690739
79Macrocytic anemia (HP:0001972)2.09982581
80Ectopic kidney (HP:0000086)2.09672421
81Sensorimotor neuropathy (HP:0007141)2.09448904
82Abnormality of fatty-acid metabolism (HP:0004359)2.08957093
83Median cleft lip (HP:0000161)2.07400091
84Widely patent fontanelles and sutures (HP:0004492)2.07363564
85Submucous cleft hard palate (HP:0000176)2.06170549
86Optic nerve coloboma (HP:0000588)2.05787473
87Gait imbalance (HP:0002141)2.05502982
88Abnormality of pyrimidine metabolism (HP:0004353)2.05406565
89Increased CSF lactate (HP:0002490)2.05333543
90Aplasia/Hypoplasia of the lens (HP:0008063)2.03773581
91Abnormal urine phosphate concentration (HP:0012599)2.03227868
92Nephroblastoma (Wilms tumor) (HP:0002667)2.01402545
93Alveolar cell carcinoma (HP:0006519)2.00838258
94Reticulocytopenia (HP:0001896)2.00083523
95Cerebral edema (HP:0002181)1.99958744
96Abnormality of the septum pellucidum (HP:0007375)1.98698484
97Polyphagia (HP:0002591)1.98007827
98Long nose (HP:0003189)1.97657191
99Nausea (HP:0002018)1.97536026
100Systemic lupus erythematosus (HP:0002725)1.96945056
101Aplasia/Hypoplasia of the uvula (HP:0010293)1.96370811
102Abnormality of midbrain morphology (HP:0002418)1.95888324
103Molar tooth sign on MRI (HP:0002419)1.95888324
104Spastic paraparesis (HP:0002313)1.95584211
105Abnormality of abdominal situs (HP:0011620)1.95226715
106Abdominal situs inversus (HP:0003363)1.95226715
107Thoracic kyphosis (HP:0002942)1.93222446
108Abnormality of molar (HP:0011077)1.92843602
109Abnormality of molar morphology (HP:0011070)1.92843602
110Stage 5 chronic kidney disease (HP:0003774)1.92606065
111Purpura (HP:0000979)1.92467722
112Opisthotonus (HP:0002179)1.90358135
113Increased muscle lipid content (HP:0009058)1.90286331
114Increased corneal curvature (HP:0100692)1.89134903
115Keratoconus (HP:0000563)1.89134903
116Gout (HP:0001997)1.88751980
117Hypoplasia of the thymus (HP:0000778)1.87972815
118Congenital primary aphakia (HP:0007707)1.87751974
119Male pseudohermaphroditism (HP:0000037)1.86710779
120Embryonal renal neoplasm (HP:0011794)1.86679861
121Pancreatic fibrosis (HP:0100732)1.86642303
122Retinal atrophy (HP:0001105)1.86351965
123Carpal bone hypoplasia (HP:0001498)1.86230353
124Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.85968424
125Absent rod-and cone-mediated responses on ERG (HP:0007688)1.85881516
126Abnormality of renal resorption (HP:0011038)1.85738145
127Myokymia (HP:0002411)1.85199405
128Hepatocellular necrosis (HP:0001404)1.84578573
129Abnormality of the preputium (HP:0100587)1.84447610
130Attenuation of retinal blood vessels (HP:0007843)1.82798210
131Prolonged neonatal jaundice (HP:0006579)1.82422878
132Genital tract atresia (HP:0001827)1.81844346
133Shoulder girdle muscle weakness (HP:0003547)1.81061955
134Nephrogenic diabetes insipidus (HP:0009806)1.79967542
135True hermaphroditism (HP:0010459)1.77762865
136Hyperammonemia (HP:0001987)1.77333987
137Clubbing of toes (HP:0100760)1.77020649
138Metabolic acidosis (HP:0001942)1.76678262
139Abnormality of the dental pulp (HP:0006479)1.76616561
140Anomalous pulmonary venous return (HP:0010772)1.75520376
141Abnormality of cells of the erythroid lineage (HP:0012130)1.75354408
142Abnormal pupillary function (HP:0007686)1.74614959
143Dysphonia (HP:0001618)1.73812404
144Lethargy (HP:0001254)1.73714068
145Neoplasm of the tracheobronchial system (HP:0100552)1.73416872
146Parakeratosis (HP:0001036)1.73319921
147Retinal dysplasia (HP:0007973)1.73104841
148Abnormality of dental color (HP:0011073)1.72961376
149Aplasia/Hypoplasia of the sacrum (HP:0008517)1.72905957
150Retinitis pigmentosa (HP:0000510)1.71293072
151White forelock (HP:0002211)1.71208657
152Progressive macrocephaly (HP:0004481)1.70699512
153Cortical visual impairment (HP:0100704)1.70558148
154Small hand (HP:0200055)1.69927067
155Ureteral duplication (HP:0000073)1.69887821
156Abnormality of renal excretion (HP:0011036)1.69434512
157Febrile seizures (HP:0002373)1.69274635
158Occipital encephalocele (HP:0002085)1.69111592
159Optic disc pallor (HP:0000543)1.68805310
160Meckel diverticulum (HP:0002245)1.67058453
161Astigmatism (HP:0000483)1.66234959
162Renal agenesis (HP:0000104)1.64861803
163Vaginal atresia (HP:0000148)1.64824334
164Dyschromatopsia (HP:0007641)1.64791234
165Osteomalacia (HP:0002749)1.64459917
166Aplasia cutis congenita (HP:0001057)1.64048387
167Congenital hepatic fibrosis (HP:0002612)1.63954361
168Focal motor seizures (HP:0011153)1.63194124
169Abnormality of the dental root (HP:0006486)1.62533989
170Taurodontia (HP:0000679)1.62533989
171Abnormality of permanent molar morphology (HP:0011071)1.62533989
172Hyperventilation (HP:0002883)1.60974998
173Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.60463911
174Bronchitis (HP:0012387)1.59684708
175Abnormality of the ileum (HP:0001549)1.59415007
176Patchy hypopigmentation of hair (HP:0011365)1.57463716
177Transposition of the great arteries (HP:0001669)1.56900607
178Abnormal connection of the cardiac segments (HP:0011545)1.56900607
179Abnormal ventriculo-arterial connection (HP:0011563)1.56900607
180Congenital stationary night blindness (HP:0007642)1.56588758
181Renal dysplasia (HP:0000110)1.54744199
182Preaxial hand polydactyly (HP:0001177)1.54657980
183Absent radius (HP:0003974)1.52690070
184Postaxial hand polydactyly (HP:0001162)1.52620251
185Abnormality of the pulmonary veins (HP:0011718)1.52559542
186Nephropathy (HP:0000112)1.52252322

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SCYL23.92301377
2VRK23.80874374
3CASK3.48012470
4STK163.25885713
5MAP3K113.12189894
6MAP4K22.97275740
7TNIK2.57926127
8BLK2.54690022
9BMPR1B2.32089525
10STK392.24285553
11PNCK2.22792461
12BCKDK2.17917860
13TESK22.12799162
14MAP2K72.11775326
15TAF12.08252336
16MAPK152.06699589
17MKNK22.06482078
18TAOK21.97473219
19ACVR1B1.96122505
20NME21.93277011
21PKN11.92001884
22PDK31.84605236
23PDK41.84605236
24MARK11.83935128
25MAP3K141.82024096
26IRAK41.81839713
27ZAK1.81451584
28IRAK31.76383810
29DDR21.73057927
30PBK1.69804356
31INSRR1.66065939
32MKNK11.60120650
33EIF2AK21.59619711
34IRAK21.58238721
35CAMKK21.56422680
36MAPK131.55261322
37TAOK11.54607921
38NEK61.53982049
39EPHA21.49383594
40PDK21.49200250
41BRAF1.41067876
42GRK61.35444259
43BRSK21.31490558
44ICK1.31341666
45IRAK11.28866741
46WNK41.28608973
47BMPR21.27835806
48GRK11.27480534
49ADRBK21.26378942
50YES11.22145779
51MAP3K121.17478716
52MST1R1.17455373
53OXSR11.16939983
54NME11.16776349
55CDK31.16635751
56TESK11.15346515
57PRKD31.12868806
58PASK1.11460798
59MST41.08767897
60PINK11.06353470
61KDR1.06018348
62SRPK11.04389375
63SIK31.02488823
64NEK11.01677723
65ARAF1.01601131
66CAMK1G1.01567684
67MATK1.01488322
68BUB11.00886233
69CDK71.00569982
70MAP3K40.95807481
71ABL20.93844097
72MUSK0.93688715
73TXK0.93168927
74BCR0.91748110
75PIM20.88616392
76GRK70.88472743
77WNK10.85032021
78NTRK20.82979854
79MAPKAPK50.79831592
80TNK20.79759001
81DYRK20.79656475
82EPHB20.78491745
83DYRK1A0.77861923
84PRKCE0.77030819
85AKT30.74988597
86BMX0.74639789
87NTRK30.74007770
88CLK10.73579610
89LIMK10.72378667
90PRKG10.71223423
91PRKCQ0.70214384
92VRK10.69221586
93CAMKK10.69156610
94SIK20.68170959
95PRPF4B0.66131008
96PLK40.65285383
97SGK2230.64390803
98SGK4940.64390803
99SGK20.64131278
100ERBB30.63280864
101CAMK1D0.62968927
102TLK10.61853749
103NUAK10.61813623
104TIE10.61754452
105PIK3CG0.60080803
106PRKCZ0.59791908
107CSNK1G30.59599946
108ERBB20.58306569
109CAMK2A0.58253878
110FGR0.58119890
111AURKA0.57516864
112PTK2B0.56669764
113ZAP700.56503446
114CSNK1G20.55300658
115GRK50.54525333
116STK38L0.53272430
117FES0.51337323
118MAP2K20.50282800
119MARK20.50148608
120PRKCI0.49556058
121CDK190.49119312
122PRKCG0.47612793
123MAP4K10.46670535
124MAPKAPK30.46461143
125RPS6KA10.45959244
126WEE10.45506873
127PLK10.45333595
128CAMK2G0.44945388
129BRSK10.44937030
130MAP3K130.41856571
131CSNK1G10.41676753
132MAP3K30.40838562
133PRKACA0.40654706
134RPS6KA50.40630018
135EIF2AK10.40596683
136CAMK2B0.40519773
137BRD40.40443191
138RPS6KA40.40341499
139NEK90.40314825
140EPHA40.38837087
141FLT30.38386274
142UHMK10.35986904
143STK110.35812685
144CDK80.35552379
145EPHB10.35202310
146PLK20.34195004
147LYN0.34116043
148ATM0.33904672
149SGK10.33848043
150MAP3K70.32623580
151WNK30.31071274
152DYRK30.30746300
153MARK30.30317696
154DYRK1B0.30010015
155PRKCB0.29985011
156CSNK2A10.29963102
157CSNK1A10.29626230
158TBK10.29447879
159RPS6KA20.28981930
160PRKG20.28021849
161PRKD20.26041672

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041223.64615937
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.63419007
3Ribosome_Homo sapiens_hsa030103.02671941
4Fanconi anemia pathway_Homo sapiens_hsa034602.98321882
5Nicotine addiction_Homo sapiens_hsa050332.83831910
6Phototransduction_Homo sapiens_hsa047442.37710009
7Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.31569559
8Linoleic acid metabolism_Homo sapiens_hsa005912.30175254
9Vitamin B6 metabolism_Homo sapiens_hsa007502.22787819
10Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.20306619
11Ether lipid metabolism_Homo sapiens_hsa005652.19938433
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.17691076
13Base excision repair_Homo sapiens_hsa034102.10943620
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.09803705
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.05319550
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.00651853
17Primary bile acid biosynthesis_Homo sapiens_hsa001201.97535994
18Taste transduction_Homo sapiens_hsa047421.96005555
19Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.95931096
20Arachidonic acid metabolism_Homo sapiens_hsa005901.90066485
21Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.77156149
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.75937901
23Peroxisome_Homo sapiens_hsa041461.74747286
24Autoimmune thyroid disease_Homo sapiens_hsa053201.71903091
25Fatty acid degradation_Homo sapiens_hsa000711.63772054
26Morphine addiction_Homo sapiens_hsa050321.63348853
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.60502066
28Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.55467128
29Tryptophan metabolism_Homo sapiens_hsa003801.54803463
30Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.54778426
31Steroid hormone biosynthesis_Homo sapiens_hsa001401.52513949
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.47067458
33Tyrosine metabolism_Homo sapiens_hsa003501.46406304
34Basal transcription factors_Homo sapiens_hsa030221.45520445
35Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.45362370
36Sphingolipid metabolism_Homo sapiens_hsa006001.42538693
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.42319843
38Butanoate metabolism_Homo sapiens_hsa006501.42215754
39Serotonergic synapse_Homo sapiens_hsa047261.42017162
40Fat digestion and absorption_Homo sapiens_hsa049751.40033823
41Mismatch repair_Homo sapiens_hsa034301.35962311
42Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.34005978
43Folate biosynthesis_Homo sapiens_hsa007901.33808302
44Biosynthesis of amino acids_Homo sapiens_hsa012301.33258803
45Caffeine metabolism_Homo sapiens_hsa002321.33113489
46Non-homologous end-joining_Homo sapiens_hsa034501.31890910
47Fatty acid biosynthesis_Homo sapiens_hsa000611.29652809
48Glutamatergic synapse_Homo sapiens_hsa047241.29632089
49Graft-versus-host disease_Homo sapiens_hsa053321.27243548
50Starch and sucrose metabolism_Homo sapiens_hsa005001.26096667
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.25302325
52Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.24555421
53Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.24331795
54Glycosaminoglycan degradation_Homo sapiens_hsa005311.22209460
55Renin-angiotensin system_Homo sapiens_hsa046141.19429649
56Ovarian steroidogenesis_Homo sapiens_hsa049131.17349653
57Sulfur metabolism_Homo sapiens_hsa009201.15950640
58Pyruvate metabolism_Homo sapiens_hsa006201.13744064
59Amphetamine addiction_Homo sapiens_hsa050311.13513868
60Allograft rejection_Homo sapiens_hsa053301.11924317
61Fatty acid elongation_Homo sapiens_hsa000621.11830799
62Axon guidance_Homo sapiens_hsa043601.10720658
63Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.10131222
64Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.09829159
65Rheumatoid arthritis_Homo sapiens_hsa053231.08774446
66Fructose and mannose metabolism_Homo sapiens_hsa000511.08357218
67Calcium signaling pathway_Homo sapiens_hsa040201.05995399
68Oxidative phosphorylation_Homo sapiens_hsa001901.05552636
69Vitamin digestion and absorption_Homo sapiens_hsa049771.04716979
70PPAR signaling pathway_Homo sapiens_hsa033201.03397456
71Basal cell carcinoma_Homo sapiens_hsa052171.02406873
72Huntingtons disease_Homo sapiens_hsa050161.02223964
73Galactose metabolism_Homo sapiens_hsa000521.00653179
74Fatty acid metabolism_Homo sapiens_hsa012121.00367207
75GABAergic synapse_Homo sapiens_hsa047270.98015597
76Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.97558395
77Purine metabolism_Homo sapiens_hsa002300.96035476
78Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.95452062
79Olfactory transduction_Homo sapiens_hsa047400.93980260
80Arginine biosynthesis_Homo sapiens_hsa002200.93328593
81Retinol metabolism_Homo sapiens_hsa008300.93099107
82Histidine metabolism_Homo sapiens_hsa003400.92888809
83Hedgehog signaling pathway_Homo sapiens_hsa043400.92713363
84Steroid biosynthesis_Homo sapiens_hsa001000.91985321
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.91950179
86NF-kappa B signaling pathway_Homo sapiens_hsa040640.90698716
87Cyanoamino acid metabolism_Homo sapiens_hsa004600.89741922
88Wnt signaling pathway_Homo sapiens_hsa043100.88601335
89Circadian entrainment_Homo sapiens_hsa047130.87211779
90Collecting duct acid secretion_Homo sapiens_hsa049660.86187799
91Carbon metabolism_Homo sapiens_hsa012000.85951041
92Asthma_Homo sapiens_hsa053100.85441520
93Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.84853007
94Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.84210051
95Bile secretion_Homo sapiens_hsa049760.83202131
96Cocaine addiction_Homo sapiens_hsa050300.82918756
97Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.82423987
98Cysteine and methionine metabolism_Homo sapiens_hsa002700.81975810
99Insulin secretion_Homo sapiens_hsa049110.81236512
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.74310137
101Homologous recombination_Homo sapiens_hsa034400.73239734
102Mineral absorption_Homo sapiens_hsa049780.72885731
103Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.72541163
104Regulation of autophagy_Homo sapiens_hsa041400.71205910
105Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.70399117
106Salivary secretion_Homo sapiens_hsa049700.68519502
107Glycerolipid metabolism_Homo sapiens_hsa005610.68400150
108Propanoate metabolism_Homo sapiens_hsa006400.68249909
109Protein export_Homo sapiens_hsa030600.67927083
110Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.67339919
111Renin secretion_Homo sapiens_hsa049240.64158356
112Cardiac muscle contraction_Homo sapiens_hsa042600.63410839
113RNA polymerase_Homo sapiens_hsa030200.60758559
114Alzheimers disease_Homo sapiens_hsa050100.60645083
115Intestinal immune network for IgA production_Homo sapiens_hsa046720.59251141
116Glycerophospholipid metabolism_Homo sapiens_hsa005640.56889284
117DNA replication_Homo sapiens_hsa030300.56884545
118Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.56744169
119Hematopoietic cell lineage_Homo sapiens_hsa046400.55387520
120beta-Alanine metabolism_Homo sapiens_hsa004100.54457312
121Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54260493
122Ras signaling pathway_Homo sapiens_hsa040140.53879821
123cAMP signaling pathway_Homo sapiens_hsa040240.53113576
124Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52284806
125Synaptic vesicle cycle_Homo sapiens_hsa047210.51591250
126Parkinsons disease_Homo sapiens_hsa050120.50294009
127SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49194077
128Antigen processing and presentation_Homo sapiens_hsa046120.48585096
129Glutathione metabolism_Homo sapiens_hsa004800.48276374
130Nitrogen metabolism_Homo sapiens_hsa009100.48028771
131Dopaminergic synapse_Homo sapiens_hsa047280.47372638
132Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.47156417
133Phenylalanine metabolism_Homo sapiens_hsa003600.47119420
134Protein digestion and absorption_Homo sapiens_hsa049740.46564385
135Pyrimidine metabolism_Homo sapiens_hsa002400.46288684
136Chemical carcinogenesis_Homo sapiens_hsa052040.45952513
137Other glycan degradation_Homo sapiens_hsa005110.42310953
138Arginine and proline metabolism_Homo sapiens_hsa003300.42193396
139Malaria_Homo sapiens_hsa051440.41769551
140Proteasome_Homo sapiens_hsa030500.41011227
141NOD-like receptor signaling pathway_Homo sapiens_hsa046210.37865527
142African trypanosomiasis_Homo sapiens_hsa051430.36418003
143RNA degradation_Homo sapiens_hsa030180.35379017
144Maturity onset diabetes of the young_Homo sapiens_hsa049500.35126310
145Phagosome_Homo sapiens_hsa041450.35054250
146Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34199058
147Measles_Homo sapiens_hsa051620.33652525
148Alcoholism_Homo sapiens_hsa050340.33471978
149Metabolic pathways_Homo sapiens_hsa011000.33144170
150Pancreatic secretion_Homo sapiens_hsa049720.32401324
151Gastric acid secretion_Homo sapiens_hsa049710.32042343
152Primary immunodeficiency_Homo sapiens_hsa053400.28076751
153RNA transport_Homo sapiens_hsa030130.26731686
154Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.24252409
155Pentose phosphate pathway_Homo sapiens_hsa000300.21779547
156Spliceosome_Homo sapiens_hsa030400.20453747
157Complement and coagulation cascades_Homo sapiens_hsa046100.20114912

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