MLYCD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene catalyzes the breakdown of malonyl-CoA to acetyl-CoA and carbon dioxide. Malonyl-CoA is an intermediate in fatty acid biosynthesis, and also inhibits the transport of fatty acyl CoAs into mitochondria. Consequently, the encoded protein acts to increase the rate of fatty acid oxidation. It is found in mitochondria, peroxisomes, and the cytoplasm. Mutations in this gene result in malonyl-CoA decarboyxlase deficiency. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.85877883
2L-phenylalanine catabolic process (GO:0006559)6.85877883
3L-phenylalanine metabolic process (GO:0006558)6.66607793
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.66607793
5aromatic amino acid family catabolic process (GO:0009074)6.01543889
6myofibril assembly (GO:0030239)5.99023793
7muscle filament sliding (GO:0030049)5.97839336
8actin-myosin filament sliding (GO:0033275)5.97839336
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.73001740
10glyoxylate metabolic process (GO:0046487)5.56173600
11kynurenine metabolic process (GO:0070189)5.46960983
12sarcomere organization (GO:0045214)5.35372459
13alpha-linolenic acid metabolic process (GO:0036109)5.35134205
14indole-containing compound catabolic process (GO:0042436)5.31268621
15indolalkylamine catabolic process (GO:0046218)5.31268621
16tryptophan catabolic process (GO:0006569)5.31268621
17lysine catabolic process (GO:0006554)5.30431065
18lysine metabolic process (GO:0006553)5.30431065
19bile acid biosynthetic process (GO:0006699)5.21521927
20cardiac myofibril assembly (GO:0055003)5.12353276
21cysteine metabolic process (GO:0006534)5.05206790
22fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.04374044
23tryptophan metabolic process (GO:0006568)5.00787385
24sulfur amino acid catabolic process (GO:0000098)4.99718817
25actin-mediated cell contraction (GO:0070252)4.94683110
26sarcoplasmic reticulum calcium ion transport (GO:0070296)4.91952548
27urea metabolic process (GO:0019627)4.90624048
28urea cycle (GO:0000050)4.90624048
29regulation of triglyceride catabolic process (GO:0010896)4.78647305
30high-density lipoprotein particle remodeling (GO:0034375)4.77333792
31negative regulation of fibrinolysis (GO:0051918)4.76300891
32cellular ketone body metabolic process (GO:0046950)4.67552943
33amino-acid betaine metabolic process (GO:0006577)4.66492712
34regulation of relaxation of muscle (GO:1901077)4.65737774
35serine family amino acid catabolic process (GO:0009071)4.63256052
36peptidyl-glutamic acid carboxylation (GO:0017187)4.61908808
37protein carboxylation (GO:0018214)4.61908808
38complement activation, alternative pathway (GO:0006957)4.56099927
39regulation of skeletal muscle contraction (GO:0014819)4.55835113
40nitrogen cycle metabolic process (GO:0071941)4.54780064
41response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.53300821
42regulation of fibrinolysis (GO:0051917)4.52017313
43regulation of protein activation cascade (GO:2000257)4.44348001
44bile acid metabolic process (GO:0008206)4.42759151
45alpha-amino acid catabolic process (GO:1901606)4.37633434
46aromatic amino acid family metabolic process (GO:0009072)4.36003741
472-oxoglutarate metabolic process (GO:0006103)4.35722170
48fatty acid beta-oxidation (GO:0006635)4.32819122
49homocysteine metabolic process (GO:0050667)4.31569643
50triglyceride homeostasis (GO:0070328)4.26840773
51acylglycerol homeostasis (GO:0055090)4.26840773
52regulation of sequestering of triglyceride (GO:0010889)4.25231659
53short-chain fatty acid metabolic process (GO:0046459)4.22453352
54regulation of cholesterol esterification (GO:0010872)4.18596952
55reverse cholesterol transport (GO:0043691)4.18324499
56carnitine transmembrane transport (GO:1902603)4.17718804
57cardiac muscle hypertrophy (GO:0003300)4.17290043
58ethanol oxidation (GO:0006069)4.17137082
59tyrosine metabolic process (GO:0006570)4.14981029
60regulation of complement activation (GO:0030449)4.14666099
61aspartate family amino acid catabolic process (GO:0009068)4.14442444
62plasma lipoprotein particle remodeling (GO:0034369)4.14266741
63protein-lipid complex remodeling (GO:0034368)4.14266741
64macromolecular complex remodeling (GO:0034367)4.14266741
65regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.12896385
66striated muscle contraction (GO:0006941)4.12475479
67cellular amino acid catabolic process (GO:0009063)4.11956340
68fatty acid oxidation (GO:0019395)4.10596899
69fatty acid catabolic process (GO:0009062)4.05712774
70ketone body metabolic process (GO:1902224)4.03448250
71plasma lipoprotein particle clearance (GO:0034381)4.02478408
72lipid oxidation (GO:0034440)4.02268290
73cardiac muscle contraction (GO:0060048)4.01351472
74amino-acid betaine transport (GO:0015838)4.00923170
75carnitine transport (GO:0015879)4.00923170
76glutamate metabolic process (GO:0006536)3.99213647
77skeletal muscle contraction (GO:0003009)3.98943654
78monocarboxylic acid catabolic process (GO:0072329)3.97184039
79cellular modified amino acid catabolic process (GO:0042219)3.95551796
80striated muscle hypertrophy (GO:0014897)3.95430796
81negative regulation of cholesterol transport (GO:0032375)3.94576849
82negative regulation of sterol transport (GO:0032372)3.94576849
83* acetyl-CoA metabolic process (GO:0006084)3.94216499
84phospholipid efflux (GO:0033700)3.94085533
85dicarboxylic acid biosynthetic process (GO:0043650)3.90480695
86glycine metabolic process (GO:0006544)3.85758373
87valine metabolic process (GO:0006573)3.85731891
88organic acid catabolic process (GO:0016054)3.85630346
89carboxylic acid catabolic process (GO:0046395)3.85630346
90actin filament-based movement (GO:0030048)3.83623935
91regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.83462126
92actomyosin structure organization (GO:0031032)3.81972952
93carnitine metabolic process (GO:0009437)3.81741619
94positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.79850157
95fatty acid transmembrane transport (GO:1902001)3.78760464
96positive regulation of fatty acid beta-oxidation (GO:0032000)3.76127987
97creatine metabolic process (GO:0006600)3.75711224
98serine family amino acid metabolic process (GO:0009069)3.74476478
99indolalkylamine metabolic process (GO:0006586)3.74171721
100regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.73042179
101muscle hypertrophy (GO:0014896)3.70298278
102bile acid and bile salt transport (GO:0015721)3.70066627
103benzene-containing compound metabolic process (GO:0042537)3.69820030
104cellular glucuronidation (GO:0052695)3.69783529
105response to inactivity (GO:0014854)3.69765719
106positive regulation of lipid catabolic process (GO:0050996)3.69553958
107skeletal muscle adaptation (GO:0043501)3.68309231
108phospholipid homeostasis (GO:0055091)3.62592348
109* coenzyme catabolic process (GO:0009109)3.61490201
110branched-chain amino acid catabolic process (GO:0009083)3.60899073
111adult heart development (GO:0007512)3.58815910
112imidazole-containing compound metabolic process (GO:0052803)3.57418187
113amine catabolic process (GO:0009310)3.56185124
114cellular biogenic amine catabolic process (GO:0042402)3.56185124
115positive regulation of lipoprotein lipase activity (GO:0051006)3.53031820
116positive regulation of triglyceride lipase activity (GO:0061365)3.53031820
117cholesterol efflux (GO:0033344)3.52667929
118carnitine shuttle (GO:0006853)3.52182771
119response to muscle activity (GO:0014850)3.51674415
120drug catabolic process (GO:0042737)3.51280889
121arginine metabolic process (GO:0006525)3.49483633
122quaternary ammonium group transport (GO:0015697)3.47586694
123negative regulation of lipase activity (GO:0060192)3.47460689
124regulation of cholesterol homeostasis (GO:2000188)3.46595928
125aldehyde catabolic process (GO:0046185)3.44365954
126plasma lipoprotein particle assembly (GO:0034377)3.43683286
127regulation of cholesterol metabolic process (GO:0090181)3.42645670
128serine family amino acid biosynthetic process (GO:0009070)3.40548754
129branched-chain amino acid metabolic process (GO:0009081)3.40178605
130cholesterol homeostasis (GO:0042632)3.40034745
131regulation of sarcomere organization (GO:0060297)3.34811263
132sterol homeostasis (GO:0055092)3.34427020
133muscle contraction (GO:0006936)3.34032444
134striated muscle adaptation (GO:0014888)3.31888011
135low-density lipoprotein particle remodeling (GO:0034374)3.31496768
136positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.29737790
137regulation of actin filament-based movement (GO:1903115)3.29671467
138striated muscle atrophy (GO:0014891)3.28921224
139negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.26256277
140cardiac muscle hypertrophy in response to stress (GO:0014898)3.15767551
141muscle hypertrophy in response to stress (GO:0003299)3.15767551
142cardiac muscle adaptation (GO:0014887)3.15767551
143regulation of cell communication by electrical coupling (GO:0010649)3.15443895
144muscle system process (GO:0003012)3.12621135
145* regulation of fatty acid oxidation (GO:0046320)3.07620207
146regulation of striated muscle contraction (GO:0006942)3.07080839
147exogenous drug catabolic process (GO:0042738)3.03905758
148regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.99342733
149regulation of membrane repolarization (GO:0060306)2.98078102
150membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.97728394
151positive regulation of cation channel activity (GO:2001259)2.95576417
152cardiac muscle cell development (GO:0055013)2.89935462
153negative regulation of potassium ion transmembrane transport (GO:1901380)2.89126435
154regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.87535766
155ventricular cardiac muscle cell action potential (GO:0086005)2.85360295
156response to epinephrine (GO:0071871)2.85329029
157regulation of the force of heart contraction (GO:0002026)2.84970526
158cardiac muscle tissue morphogenesis (GO:0055008)2.84501037
159epoxygenase P450 pathway (GO:0019373)2.84346146
160regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.83202437
161biotin metabolic process (GO:0006768)2.81434393
162cellular response to epinephrine stimulus (GO:0071872)2.80709361
163macroautophagy (GO:0016236)2.78761708
164muscle fiber development (GO:0048747)2.77195481
165muscle tissue morphogenesis (GO:0060415)2.76123054
166negative regulation of cAMP-mediated signaling (GO:0043951)2.73558867
167negative regulation of cytosolic calcium ion concentration (GO:0051481)2.71810060
168positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.69409502
169cardiac cell development (GO:0055006)2.66962190
170muscle atrophy (GO:0014889)2.64727609
171muscle adaptation (GO:0043500)2.64295233
172regulation of calcium ion transmembrane transporter activity (GO:1901019)2.59984698
173regulation of calcium ion transmembrane transport (GO:1903169)2.59984698
174response to caffeine (GO:0031000)2.53799146
175flavonoid metabolic process (GO:0009812)2.51011298
176myotube cell development (GO:0014904)2.50777475
177establishment of protein localization to Golgi (GO:0072600)2.50746334
178mannose metabolic process (GO:0006013)2.47108723
179positive regulation of myoblast differentiation (GO:0045663)2.43245909
180regulation of cardiac muscle contraction (GO:0055117)2.39827383
181* positive regulation of fatty acid oxidation (GO:0046321)2.39377446
182plasma membrane repair (GO:0001778)2.39268827
183relaxation of cardiac muscle (GO:0055119)2.38790365
184skeletal muscle fiber development (GO:0048741)2.37161634
185dicarboxylic acid catabolic process (GO:0043649)2.36417268
186cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.35948404
187striated muscle cell development (GO:0055002)2.35890303
188alanine transport (GO:0032328)2.35593646
189regulation of myoblast differentiation (GO:0045661)2.34981929
190glycogen catabolic process (GO:0005980)2.34952825
191interkinetic nuclear migration (GO:0022027)2.34846445

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.62557497
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.66638525
3* PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.41902078
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.92705415
5EGR1_23403033_ChIP-Seq_LIVER_Mouse5.57309752
6EZH2_22144423_ChIP-Seq_EOC_Human4.95306532
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.86007175
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.33556608
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.77765560
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.24583350
11* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.01623002
12RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.18495717
13DROSHA_22980978_ChIP-Seq_HELA_Human2.07008292
14ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.9738425
15TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.99682548
16GATA1_22025678_ChIP-Seq_K562_Human1.90545645
17* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.90525157
18ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.88670904
19CLOCK_20551151_ChIP-Seq_293T_Human1.86333115
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.72907804
21ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.64804265
22VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.63233739
23CDX2_19796622_ChIP-Seq_MESCs_Mouse1.61450780
24FOXA2_19822575_ChIP-Seq_HepG2_Human1.55553293
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52584897
26GBX2_23144817_ChIP-Seq_PC3_Human1.52007229
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.48170498
28* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.46264802
29ZNF263_19887448_ChIP-Seq_K562_Human1.45995607
30AHR_22903824_ChIP-Seq_MCF-7_Human1.45850905
31ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.35706475
32RARG_19884340_ChIP-ChIP_MEFs_Mouse1.35052326
33SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.34607432
34VDR_22108803_ChIP-Seq_LS180_Human1.34077412
35HNF4A_19822575_ChIP-Seq_HepG2_Human1.28904258
36SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26242799
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.25216783
38AR_21572438_ChIP-Seq_LNCaP_Human1.23695618
39E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.22596274
40ER_23166858_ChIP-Seq_MCF-7_Human1.21053298
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21033920
42BP1_19119308_ChIP-ChIP_Hs578T_Human1.19432219
43HTT_18923047_ChIP-ChIP_STHdh_Human1.17648233
44ARNT_22903824_ChIP-Seq_MCF-7_Human1.17290539
45EZH2_27294783_Chip-Seq_ESCs_Mouse1.16667049
46PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.16189834
47* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.16092125
48STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.13178836
49EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.12931420
50ZNF217_24962896_ChIP-Seq_MCF-7_Human1.10065424
51IGF1R_20145208_ChIP-Seq_DFB_Human1.09807989
52SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.09747754
53SMC4_20622854_ChIP-Seq_HELA_Human1.05466017
54CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.04462237
55BCAT_22108803_ChIP-Seq_LS180_Human1.04208076
56RXRA_24833708_ChIP-Seq_LIVER_Mouse1.03503770
57LXR_22292898_ChIP-Seq_THP-1_Human1.03221908
58SOX2_27498859_Chip-Seq_STOMACH_Mouse1.02936840
59STAT3_23295773_ChIP-Seq_U87_Human1.00592117
60TCF4_23295773_ChIP-Seq_U87_Human1.00131259
61TBX20_22328084_ChIP-Seq_HEART_Mouse0.98312060
62TBX20_22080862_ChIP-Seq_HEART_Mouse0.98312060
63JARID2_20075857_ChIP-Seq_MESCs_Mouse0.98044512
64ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.97046939
65POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96800387
66TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96800387
67NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.96184832
68STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.96003919
69PIAS1_25552417_ChIP-Seq_VCAP_Human0.95579805
70ESR1_20079471_ChIP-ChIP_T-47D_Human0.94549707
71* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.94185131
72RUNX_20019798_ChIP-Seq_JUKART_Human0.94118727
73GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93911938
74SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.93794028
75NFIB_24661679_ChIP-Seq_LUNG_Mouse0.92821208
76IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.92172384
77OCT4_19829295_ChIP-Seq_ESCs_Human0.91746294
78AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90401509
79AR_19668381_ChIP-Seq_PC3_Human0.89651027
80ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.89569216
81* SMAD4_21741376_ChIP-Seq_HESCs_Human0.89472412
82* ERA_21632823_ChIP-Seq_H3396_Human0.87665924
83CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.86680397
84ESR2_21235772_ChIP-Seq_MCF-7_Human0.86327806
85MTF2_20144788_ChIP-Seq_MESCs_Mouse0.86296804
86EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.86184186
87* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.85805869
88* PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.85377142
89CTNNB1_20460455_ChIP-Seq_HCT116_Human0.84784305
90SMAD4_21799915_ChIP-Seq_A2780_Human0.84768807
91RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.84114948
92WDR5_24793694_ChIP-Seq_LNCAP_Human0.83955845
93KDM2B_26808549_Chip-Seq_SUP-B15_Human0.83314624
94NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.83063566
95CBX2_27304074_Chip-Seq_ESCs_Mouse0.82857605
96* SMAD3_21741376_ChIP-Seq_HESCs_Human0.82041349
97SUZ12_27294783_Chip-Seq_ESCs_Mouse0.81285270
98BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.81277709
99GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80914052
100IRF8_22096565_ChIP-ChIP_GC-B_Human0.80821025
101RUNX1_27514584_Chip-Seq_MCF-7_Human0.80442270
102SOX2_21211035_ChIP-Seq_LN229_Gbm0.79886999
103MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.79729498
104TP63_22573176_ChIP-Seq_HFKS_Human0.79492387
105OCT1_27270436_Chip-Seq_PROSTATE_Human0.79174161
106E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.76978152
107GATA4_25053715_ChIP-Seq_YYC3_Human0.76926053
108RXR_22108803_ChIP-Seq_LS180_Human0.76442206
109RNF2_27304074_Chip-Seq_ESCs_Mouse0.76353969
110GATA1_19941827_ChIP-Seq_MEL_Mouse0.76047917
111STAT3_1855785_ChIP-Seq_MESCs_Mouse0.75725209
112VDR_24787735_ChIP-Seq_THP-1_Human0.75016717
113TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.74800969
114* RAC3_21632823_ChIP-Seq_H3396_Human0.74198963
115SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.74052782
116SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.73904185
117GATA1_19941826_ChIP-Seq_K562_Human0.73305709
118AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.71986711
119AUTS2_25519132_ChIP-Seq_293T-REX_Human0.71125953
120* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.70802748
121RARA_24833708_ChIP-Seq_LIVER_Mouse0.70056556
122CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.70046657
123PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.69278250
124EGR1_19032775_ChIP-ChIP_M12_Human0.69143778
125PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.67749525
126RAD21_21589869_ChIP-Seq_MESCs_Mouse0.66384760
127FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.65999740
128SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.65565747
129BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.64731519
130GATA2_19941826_ChIP-Seq_K562_Human0.62162707
131CEBPB_22108803_ChIP-Seq_LS180_Human0.61399648
132RACK7_27058665_Chip-Seq_MCF-7_Human0.59368191
133MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.59351112
134* RARB_24833708_ChIP-Seq_LIVER_Mouse0.58231794
135BCOR_27268052_Chip-Seq_Bcells_Human0.57480610
136* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.56345077
137BCL6_27268052_Chip-Seq_Bcells_Human0.56319782
138* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.55642835
139AR_20517297_ChIP-Seq_VCAP_Human0.55428565
140LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.54546344
141* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.54017354
142ESR1_15608294_ChIP-ChIP_MCF-7_Human0.53699779
143P53_21459846_ChIP-Seq_SAOS-2_Human0.53688361
144TAF2_19829295_ChIP-Seq_ESCs_Human0.53604560
145PPAR_26484153_Chip-Seq_NCI-H1993_Human0.53480819
146TET1_21451524_ChIP-Seq_MESCs_Mouse0.53453401
147FOXA1_25552417_ChIP-Seq_VCAP_Human0.53215891
148CTCF_27219007_Chip-Seq_Bcells_Human0.53072139
149EP300_21415370_ChIP-Seq_HL-1_Mouse0.53028563
150ESR1_21235772_ChIP-Seq_MCF-7_Human0.52892368
151CTCF_21964334_ChIP-Seq_BJAB-B_Human0.52712751
152RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.52363929
153Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.52268123
154CTCF_21964334_Chip-Seq_Bcells_Human0.51562286
155DNAJC2_21179169_ChIP-ChIP_NT2_Human0.50282479
156FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.49456478
157P68_20966046_ChIP-Seq_HELA_Human0.49408245
158* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.49218439
159* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.49218439
160* OCT4_20526341_ChIP-Seq_ESCs_Human0.49178407
161PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.48304206
162FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.48101196
163SPI1_20517297_ChIP-Seq_HL60_Human0.47676829
164CBP_21632823_ChIP-Seq_H3396_Human0.47307245
165ERG_20517297_ChIP-Seq_VCAP_Human0.46790554
166FOXO3_23340844_ChIP-Seq_DLD1_Human0.46654332
167GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.46467441
168PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.46463293
169PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.46339640
170CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.46254558

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.45379065
2MP0005360_urolithiasis6.61986687
3MP0005085_abnormal_gallbladder_physiolo5.69211407
4MP0005365_abnormal_bile_salt5.62785792
5MP0008875_abnormal_xenobiotic_pharmacok4.42710132
6MP0003806_abnormal_nucleotide_metabolis3.94934073
7MP0004145_abnormal_muscle_electrophysio3.85676661
8MP0003252_abnormal_bile_duct3.49062041
9MP0010329_abnormal_lipoprotein_level3.32993257
10MP0009840_abnormal_foam_cell3.15633060
11MP0005083_abnormal_biliary_tract3.02005288
12MP0005332_abnormal_amino_acid2.77772292
13MP0003195_calcinosis2.72746210
14MP0002837_dystrophic_cardiac_calcinosis2.69330986
15MP0001666_abnormal_nutrient_absorption2.56793969
16MP0003191_abnormal_cellular_cholesterol2.37046947
17MP0004233_abnormal_muscle_weight2.28640223
18MP0002118_abnormal_lipid_homeostasis2.17343137
19MP0004484_altered_response_of2.16674931
20MP0000609_abnormal_liver_physiology2.05968241
21MP0004510_myositis2.03004170
22MP0005319_abnormal_enzyme/_coenzyme1.89751603
23MP0005369_muscle_phenotype1.87634462
24MP0004130_abnormal_muscle_cell1.83861357
25MP0002138_abnormal_hepatobiliary_system1.76865044
26MP0006036_abnormal_mitochondrial_physio1.73061229
27MP0004019_abnormal_vitamin_homeostasis1.72950482
28MP0003646_muscle_fatigue1.70923701
29MP0005584_abnormal_enzyme/coenzyme_acti1.68217764
30MP0003868_abnormal_feces_composition1.67187703
31MP0002127_abnormal_cardiovascular_syste1.67072417
32MP0005670_abnormal_white_adipose1.55059024
33MP0003045_fibrosis1.50228326
34MP0001764_abnormal_homeostasis1.49688517
35MP0000750_abnormal_muscle_regeneration1.48384023
36MP0003879_abnormal_hair_cell1.44356736
37MP0009643_abnormal_urine_homeostasis1.42954116
38MP0005451_abnormal_body_composition1.41874684
39MP0004085_abnormal_heartbeat1.37694225
40MP0002108_abnormal_muscle_morphology1.34616863
41MP0003656_abnormal_erythrocyte_physiolo1.28185000
42MP0005330_cardiomyopathy1.25109284
43MP0003186_abnormal_redox_activity1.21239630
44MP0000013_abnormal_adipose_tissue1.17335269
45MP0005666_abnormal_adipose_tissue1.16421307
46MP0002971_abnormal_brown_adipose1.14130333
47MP0004036_abnormal_muscle_relaxation1.10319129
48* MP0002078_abnormal_glucose_homeostasis1.09720136
49MP0000751_myopathy1.08941836
50MP0009780_abnormal_chondrocyte_physiolo1.08360130
51MP0000598_abnormal_liver_morphology1.08336180
52MP0003705_abnormal_hypodermis_morpholog1.08332677
53MP0009697_abnormal_copulation1.07163357
54MP0002269_muscular_atrophy1.02971785
55MP0000749_muscle_degeneration1.01614185
56MP0005636_abnormal_mineral_homeostasis1.01406694
57MP0005535_abnormal_body_temperature1.01363416
58MP0000003_abnormal_adipose_tissue1.01257350
59MP0006035_abnormal_mitochondrial_morpho0.98432982
60MP0004084_abnormal_cardiac_muscle0.95729266
61MP0000604_amyloidosis0.94946454
62MP0010368_abnormal_lymphatic_system0.93606801
63MP0003011_delayed_dark_adaptation0.93264506
64MP0004215_abnormal_myocardial_fiber0.92068523
65MP0009642_abnormal_blood_homeostasis0.90869474
66MP0005334_abnormal_fat_pad0.90421183
67MP0003828_pulmonary_edema0.90063277
68MP0009763_increased_sensitivity_to0.89835906
69MP0005266_abnormal_metabolism0.89226064
70MP0005167_abnormal_blood-brain_barrier0.86112734
71MP0001501_abnormal_sleep_pattern0.85173681
72MP0008469_abnormal_protein_level0.83758140
73MP0004087_abnormal_muscle_fiber0.83504486
74MP0000569_abnormal_digit_pigmentation0.81754455
75MP0009764_decreased_sensitivity_to0.81696484
76MP0005647_abnormal_sex_gland0.81318265
77MP0005084_abnormal_gallbladder_morpholo0.80909699
78MP0005376_homeostasis/metabolism_phenot0.78984650
79MP0000747_muscle_weakness0.77196034
80MP0005220_abnormal_exocrine_pancreas0.76035443
81MP0004043_abnormal_pH_regulation0.75129497
82MP0001756_abnormal_urination0.73122381
83MP0005448_abnormal_energy_balance0.72214528
84MP0003329_amyloid_beta_deposits0.71543692
85MP0002876_abnormal_thyroid_physiology0.71358391
86MP0000266_abnormal_heart_morphology0.69075403
87MP0005386_behavior/neurological_phenoty0.68172245
88MP0004924_abnormal_behavior0.68172245
89MP0001544_abnormal_cardiovascular_syste0.68057759
90MP0005385_cardiovascular_system_phenoty0.68057759
91MP0000733_abnormal_muscle_development0.68003721
92MP0008004_abnormal_stomach_pH0.66122193
93MP0001664_abnormal_digestion0.65982826
94MP0002638_abnormal_pupillary_reflex0.65541941
95MP0000230_abnormal_systemic_arterial0.65241924
96MP0005620_abnormal_muscle_contractility0.65195613
97MP0002972_abnormal_cardiac_muscle0.64596192
98MP0003878_abnormal_ear_physiology0.64539185
99MP0005377_hearing/vestibular/ear_phenot0.64539185
100MP0004142_abnormal_muscle_tone0.64460573
101MP0004185_abnormal_adipocyte_glucose0.64170986
102MP0005375_adipose_tissue_phenotype0.64004179
103MP0005058_abnormal_lysosome_morphology0.63871314
104MP0003221_abnormal_cardiomyocyte_apopto0.62683599
105MP0000470_abnormal_stomach_morphology0.62554881
106MP0010630_abnormal_cardiac_muscle0.59171864
107MP0002693_abnormal_pancreas_physiology0.57542632
108MP0001661_extended_life_span0.57029255
109MP0002909_abnormal_adrenal_gland0.56796452
110MP0008877_abnormal_DNA_methylation0.56762275
111MP0002168_other_aberrant_phenotype0.56625314
112MP0002822_catalepsy0.56621058
113MP0009765_abnormal_xenobiotic_induced0.56309787
114MP0008775_abnormal_heart_ventricle0.55633028
115MP0001984_abnormal_olfaction0.55453029
116MP0005452_abnormal_adipose_tissue0.55068782
117MP0003953_abnormal_hormone_level0.54919552
118MP0003690_abnormal_glial_cell0.54890003
119MP0006138_congestive_heart_failure0.54354222
120MP0009046_muscle_twitch0.53864180
121MP0008872_abnormal_physiological_respon0.53632400
122MP0003137_abnormal_impulse_conducting0.51651283
123MP0008961_abnormal_basal_metabolism0.51372797
124MP0002970_abnormal_white_adipose0.51134799
125MP0000015_abnormal_ear_pigmentation0.50911499
126MP0002332_abnormal_exercise_endurance0.49859558
127MP0008874_decreased_physiological_sensi0.49353833
128MP0009115_abnormal_fat_cell0.48071505
129MP0004381_abnormal_hair_follicle0.47743601
130MP0002136_abnormal_kidney_physiology0.47391570
131MP0005408_hypopigmentation0.46479455
132MP0002106_abnormal_muscle_physiology0.45820944
133MP0002254_reproductive_system_inflammat0.44750858
134MP0003959_abnormal_lean_body0.44614791
135MP0001765_abnormal_ion_homeostasis0.44477569
136MP0003638_abnormal_response/metabolism_0.42541951
137MP0000759_abnormal_skeletal_muscle0.42113209
138MP0002928_abnormal_bile_duct0.42007874

Predicted human phenotypes

RankGene SetZ-score
1Hyporeflexia of lower limbs (HP:0002600)6.20478114
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.20473235
3Muscle fiber inclusion bodies (HP:0100299)6.09084045
4Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.93826397
5Deep venous thrombosis (HP:0002625)5.86821993
6Intrahepatic cholestasis (HP:0001406)5.73006767
7Muscle hypertrophy of the lower extremities (HP:0008968)5.62734995
8Nemaline bodies (HP:0003798)5.47775457
9Calf muscle hypertrophy (HP:0008981)5.39054838
10Xanthomatosis (HP:0000991)5.36198434
11Abnormality of monocarboxylic acid metabolism (HP:0010996)5.18890588
12Hypobetalipoproteinemia (HP:0003563)5.01950037
13Bundle branch block (HP:0011710)4.99499417
14Prolonged partial thromboplastin time (HP:0003645)4.95396571
15Type 1 muscle fiber predominance (HP:0003803)4.94856067
16Hyperlipoproteinemia (HP:0010980)4.81888217
17Abnormality of the calf musculature (HP:0001430)4.81362528
18Muscle fiber splitting (HP:0003555)4.70236426
19Hypoglycemic coma (HP:0001325)4.68545053
20* Ketosis (HP:0001946)4.62510567
21Hyperammonemia (HP:0001987)4.62370875
22EMG: myopathic abnormalities (HP:0003458)4.28293515
23Complement deficiency (HP:0004431)4.19294533
24Hyperglycinuria (HP:0003108)4.14156691
25Abnormality of fatty-acid metabolism (HP:0004359)4.10696849
26Hyperglycinemia (HP:0002154)4.09808289
27Ketoacidosis (HP:0001993)4.07624490
28Hypolipoproteinemia (HP:0010981)4.04674673
29Abnormality of glycine metabolism (HP:0010895)3.97398542
30Abnormality of serine family amino acid metabolism (HP:0010894)3.97398542
31Subaortic stenosis (HP:0001682)3.80895814
32Abnormality of the left ventricular outflow tract (HP:0011103)3.80895814
33Hypoalphalipoproteinemia (HP:0003233)3.79997690
34Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.79258452
35Myopathic facies (HP:0002058)3.76942080
36Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.74231951
37Abnormality of the common coagulation pathway (HP:0010990)3.62803232
38Joint hemorrhage (HP:0005261)3.62595756
39Epidermoid cyst (HP:0200040)3.61843072
40Difficulty running (HP:0009046)3.59038715
41Abnormality of aspartate family amino acid metabolism (HP:0010899)3.57374168
42Prolonged QT interval (HP:0001657)3.56809676
43Abnormality of glutamine family amino acid metabolism (HP:0010902)3.55372378
44Areflexia of lower limbs (HP:0002522)3.54554548
45Atrial fibrillation (HP:0005110)3.54177724
46Syncope (HP:0001279)3.53934991
47Abnormality of sulfur amino acid metabolism (HP:0004339)3.50308809
48Frequent falls (HP:0002359)3.49504671
49Dicarboxylic aciduria (HP:0003215)3.48264839
50Abnormality of dicarboxylic acid metabolism (HP:0010995)3.48264839
51Abnormality of methionine metabolism (HP:0010901)3.47382368
52EMG: neuropathic changes (HP:0003445)3.43425040
53Ventricular tachycardia (HP:0004756)3.41465663
54Neck muscle weakness (HP:0000467)3.35282403
55Abnormality of the intrinsic pathway (HP:0010989)3.28325255
56Heart block (HP:0012722)3.25694838
57Lipoatrophy (HP:0100578)3.24162908
58Fat malabsorption (HP:0002630)3.23720219
59Distal lower limb muscle weakness (HP:0009053)3.23095601
60Myoglobinuria (HP:0002913)3.20339697
61Dilated cardiomyopathy (HP:0001644)3.18935359
62Centrally nucleated skeletal muscle fibers (HP:0003687)3.15331204
63Primary atrial arrhythmia (HP:0001692)3.14458626
64Hyperventilation (HP:0002883)3.12896632
65Rimmed vacuoles (HP:0003805)3.12338628
66Ventricular fibrillation (HP:0001663)3.11906735
67Cerebral edema (HP:0002181)3.07349210
68Dysmetric saccades (HP:0000641)3.06101484
69Ventricular arrhythmia (HP:0004308)2.98742905
70Hyperbilirubinemia (HP:0002904)2.98682030
71Gout (HP:0001997)2.98355995
72Hypercholesterolemia (HP:0003124)2.96954546
73Supraventricular tachycardia (HP:0004755)2.96414485
74* Metabolic acidosis (HP:0001942)2.96205279
75Abnormality of serum amino acid levels (HP:0003112)2.96016405
76Abnormality of complement system (HP:0005339)2.95573750
77Abnormal atrioventricular conduction (HP:0005150)2.93951272
78Generalized aminoaciduria (HP:0002909)2.90705976
79Lethargy (HP:0001254)2.89010298
80Supraventricular arrhythmia (HP:0005115)2.85425510
81Abnormal EKG (HP:0003115)2.84953489
82Distal arthrogryposis (HP:0005684)2.83549139
83Delayed CNS myelination (HP:0002188)2.82379790
84Abnormality of purine metabolism (HP:0004352)2.75924104
85Increased variability in muscle fiber diameter (HP:0003557)2.73319721
86Abnormality of skeletal muscle fiber size (HP:0012084)2.72546139
87Abnormality of nucleobase metabolism (HP:0010932)2.72250228
88Round ear (HP:0100830)2.70330603
89Clumsiness (HP:0002312)2.69353985
90Oligomenorrhea (HP:0000876)2.68777855
91Conjugated hyperbilirubinemia (HP:0002908)2.66716079
92Late onset (HP:0003584)2.65695018
93Skin nodule (HP:0200036)2.65443579
94Abnormality of pyrimidine metabolism (HP:0004353)2.64902475
95Hypoglycemic seizures (HP:0002173)2.63876628
96Hyperinsulinemic hypoglycemia (HP:0000825)2.60927447
97Hyperkalemia (HP:0002153)2.54385482
98Exercise-induced myalgia (HP:0003738)2.51917823
99Right ventricular cardiomyopathy (HP:0011663)2.51736809
100Rhabdomyolysis (HP:0003201)2.51596615
101Cholelithiasis (HP:0001081)2.50479621
102Abnormal gallbladder morphology (HP:0012437)2.49766136
103Hepatic necrosis (HP:0002605)2.48624569
104Bulbar palsy (HP:0001283)2.46978094
105Scapular winging (HP:0003691)2.41533432
106Steatorrhea (HP:0002570)2.39140736
107Hepatocellular carcinoma (HP:0001402)2.38990329
108* Vomiting (HP:0002013)2.36577554
109Generalized muscle weakness (HP:0003324)2.35592290
110Genetic anticipation (HP:0003743)2.34274763
111Muscle stiffness (HP:0003552)2.30424177
112Atrioventricular block (HP:0001678)2.29170569
113Myocardial infarction (HP:0001658)2.25199590
114Increased connective tissue (HP:0009025)2.21926943
115Ulnar deviation of the wrist (HP:0003049)2.21689073
116Proximal tubulopathy (HP:0000114)2.19911932
117Myotonia (HP:0002486)2.19607929
118Neonatal onset (HP:0003623)2.19492141
119Cholecystitis (HP:0001082)2.16483690
120Abnormal gallbladder physiology (HP:0012438)2.16483690
121Muscular dystrophy (HP:0003560)2.15811751
122Postural instability (HP:0002172)2.14415527
123Acute encephalopathy (HP:0006846)2.14103436
124Spontaneous abortion (HP:0005268)2.13886085
125Pancreatitis (HP:0001733)2.12317630
126Hyperglycemia (HP:0003074)2.10743391
127Increased muscle lipid content (HP:0009058)2.09532818
128Reduced antithrombin III activity (HP:0001976)2.08781563
129Systemic lupus erythematosus (HP:0002725)2.08726438
130Abnormality of the foot musculature (HP:0001436)2.07646064
131Increased purine levels (HP:0004368)2.06748014
132Hyperuricemia (HP:0002149)2.06748014
133Left ventricular hypertrophy (HP:0001712)2.05175186
134Ragged-red muscle fibers (HP:0003200)2.04415201
135Vascular calcification (HP:0004934)2.03889604
136Sudden death (HP:0001699)2.03671131
137Exercise-induced muscle cramps (HP:0003710)2.03342334
138Irritability (HP:0000737)2.02630862
139Brushfield spots (HP:0001088)2.00410467
140Renal cortical cysts (HP:0000803)1.99816852
141Sensorimotor neuropathy (HP:0007141)1.98846758
142Glycosuria (HP:0003076)1.97800766
143Abnormality of urine glucose concentration (HP:0011016)1.97800766
144Malnutrition (HP:0004395)1.97485393
145Nausea (HP:0002018)1.97213150
146Mitral stenosis (HP:0001718)1.96397409
147Palpitations (HP:0001962)1.95634876
148Fetal akinesia sequence (HP:0001989)1.95200014
149Spastic diplegia (HP:0001264)1.94244231
150Abnormal cartilage morphology (HP:0002763)1.92864755
151Abnormality of the gallbladder (HP:0005264)1.92457031
152Foot dorsiflexor weakness (HP:0009027)1.91975989
153Protruding tongue (HP:0010808)1.91351686
154Acanthocytosis (HP:0001927)1.91112396
155Steppage gait (HP:0003376)1.90293217
156Progressive cerebellar ataxia (HP:0002073)1.89354730
157Difficulty walking (HP:0002355)1.88905450
158Amyloidosis (HP:0011034)1.86935700
159Asymmetric septal hypertrophy (HP:0001670)1.84294318
160Abnormality of proline metabolism (HP:0010907)1.84029529
161Hydroxyprolinuria (HP:0003080)1.84029529
162Abnormality of the shoulder girdle musculature (HP:0001435)1.83639301
163Hypochromic microcytic anemia (HP:0004840)1.83289925
164Facial diplegia (HP:0001349)1.83261735
165Methylmalonic aciduria (HP:0012120)1.81720906
166Cardiovascular calcification (HP:0011915)1.80014504
167Enlarged kidneys (HP:0000105)1.79625163
168Insulin-resistant diabetes mellitus (HP:0000831)1.78086992
169Acute hepatic failure (HP:0006554)1.77662270
170Gowers sign (HP:0003391)1.77638102
171Proximal amyotrophy (HP:0007126)1.74054613
172Gaze-evoked nystagmus (HP:0000640)1.70809716
173Intellectual disability, progressive (HP:0006887)1.69772338
174Hip contracture (HP:0003273)1.64087801
175Abnormality of the renal cortex (HP:0011035)1.61653485
176Decreased circulating renin level (HP:0003351)1.61510248
177Double outlet right ventricle (HP:0001719)1.61457907
178Congenital malformation of the right heart (HP:0011723)1.61457907
179Hypoplastic ischia (HP:0003175)1.57902750
180Nonprogressive disorder (HP:0003680)1.57184824
181Abnormality of potassium homeostasis (HP:0011042)1.55446433

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.12998450
2ERN13.82776076
3TRIB33.41814762
4FGFR43.17523785
5SIK13.17331673
6PKN23.09904701
7INSRR2.55847140
8TTN2.52062810
9OBSCN2.18104494
10FLT32.15495092
11AKT32.06484244
12PDK41.98774618
13PDK31.98774618
14PINK11.96328462
15TAOK31.88570973
16MAP2K41.77982543
17PIK3CG1.76007219
18PHKG11.70013940
19PHKG21.70013940
20MAP2K31.63632770
21MYLK1.55889445
22TIE11.53733221
23MAP3K71.43029182
24SGK21.42107383
25MAPK111.40275829
26LMTK21.33717959
27KDR1.27285882
28ERBB41.24173914
29MAP2K71.21961074
30PTK61.21831505
31MARK31.20429592
32NEK91.18439527
33TYK21.18227476
34PRKAA21.17242140
35TRPM71.16990536
36MARK21.14222719
37MAPK121.12448249
38EEF2K1.11491481
39SGK2231.10425803
40SGK4941.10425803
41CAMK11.08554530
42NEK11.07438484
43PDK21.06912664
44MST1R1.02607212
45CDC42BPA1.02561300
46PIK3CA1.02508132
47NLK1.01741690
48JAK21.00338106
49ABL21.00086275
50TNK20.99658058
51DAPK20.98408936
52JAK10.97425429
53EPHB10.97174343
54MAPK150.95236388
55TBK10.87636710
56PRKAA10.87234709
57RIPK10.86231432
58GRK10.85416209
59BLK0.84379175
60ACVR1B0.84189056
61MAP3K100.84023415
62RPS6KA60.83861692
63TGFBR20.82790179
64MAP3K110.79577127
65CAMK1D0.78060334
66PDPK10.76552683
67RPS6KL10.74946905
68RPS6KC10.74946905
69MAP2K60.73420045
70WNK40.72431342
71MAP3K30.72225116
72MARK10.69941576
73PRKACG0.68114712
74WNK10.67672956
75STK380.67647494
76MUSK0.67396719
77MAPK40.65355359
78RPS6KA20.65219075
79GRK60.63983199
80RET0.62337722
81MAP3K10.60519249
82MAP3K40.59847797
83HIPK20.59152220
84KSR20.58970787
85MAP3K50.58914917
86CAMK2G0.58656163
87PRKD10.58281016
88PDK10.58109843
89PAK30.56816053
90PRKD20.56578985
91FGFR20.55591445
92STK110.55232617
93MAP4K10.54753136
94SGK10.54280003
95FRK0.50594698
96PRKG10.50545305
97MAP2K10.50274574
98MELK0.49373232
99MAPK130.48682512
100FGFR30.48636333
101CDK120.47611241
102ROCK10.46780599
103PDGFRA0.46658482
104RPS6KB10.45366596
105PRKCZ0.43344671
106SGK30.42308853
107LRRK20.41858475
108LATS10.40421487
109NME20.40409200
110IKBKE0.40065488
111ZAP700.39776046
112CAMK40.39305011
113ITK0.39090526
114WNK30.38879756
115ICK0.38743860
116CSK0.38700848
117DAPK30.38311641
118PRKCH0.37927026
119BTK0.37623122
120RPS6KA30.37486587
121CHUK0.37448000
122SYK0.37444842
123GSK3A0.37379987
124DYRK1B0.36555724
125ADRBK10.36526994
126NME10.36032564
127PTK20.35425095
128CAMK1G0.35071763
129PRKCE0.35055274
130CAMKK10.34827033
131STK38L0.34641686
132MAP2K20.34489147
133PRKCQ0.33494305
134MAPKAPK30.32605581
135MAPK70.31971309
136MAP3K60.30702319
137MAP3K130.29322152
138CAMK2D0.29021525
139SCYL20.28164085
140MTOR0.27988145
141DMPK0.27654742
142EPHA30.27531923
143ILK0.27191445
144MAP3K20.26602325
145PRKACA0.26076039

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.93834270
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.49494410
3Nitrogen metabolism_Homo sapiens_hsa009103.17689629
4Fatty acid degradation_Homo sapiens_hsa000713.05538025
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.99957180
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.89299641
7Arginine biosynthesis_Homo sapiens_hsa002202.87687154
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.82184574
9Tryptophan metabolism_Homo sapiens_hsa003802.65265251
10* Propanoate metabolism_Homo sapiens_hsa006402.55802311
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.55614385
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.37412367
13Butanoate metabolism_Homo sapiens_hsa006502.34117015
14Fatty acid metabolism_Homo sapiens_hsa012122.24316514
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.23613175
16Complement and coagulation cascades_Homo sapiens_hsa046102.22454088
17* Peroxisome_Homo sapiens_hsa041462.07240275
18PPAR signaling pathway_Homo sapiens_hsa033202.03675461
19Pentose and glucuronate interconversions_Homo sapiens_hsa000402.02979631
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.95016787
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.77918643
22Pyruvate metabolism_Homo sapiens_hsa006201.77140645
23Circadian rhythm_Homo sapiens_hsa047101.72239995
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.69640139
25* beta-Alanine metabolism_Homo sapiens_hsa004101.63110546
26Carbon metabolism_Homo sapiens_hsa012001.62945671
27Histidine metabolism_Homo sapiens_hsa003401.58928464
28Chemical carcinogenesis_Homo sapiens_hsa052041.58496948
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.58335667
30Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.55089921
31Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.55074274
32Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.53937609
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.53778356
34Caffeine metabolism_Homo sapiens_hsa002321.53521832
35Fatty acid elongation_Homo sapiens_hsa000621.52041800
36Drug metabolism - other enzymes_Homo sapiens_hsa009831.46293551
37Steroid hormone biosynthesis_Homo sapiens_hsa001401.45511309
38Starch and sucrose metabolism_Homo sapiens_hsa005001.43915332
39Phenylalanine metabolism_Homo sapiens_hsa003601.43568091
40Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.43496815
41Vascular smooth muscle contraction_Homo sapiens_hsa042701.42849520
42Selenocompound metabolism_Homo sapiens_hsa004501.42524466
43Bile secretion_Homo sapiens_hsa049761.38974892
44Sulfur metabolism_Homo sapiens_hsa009201.38654115
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.35234216
46Biosynthesis of amino acids_Homo sapiens_hsa012301.34891040
47Retinol metabolism_Homo sapiens_hsa008301.32596147
48Staphylococcus aureus infection_Homo sapiens_hsa051501.32071148
49Tyrosine metabolism_Homo sapiens_hsa003501.26214953
50Fat digestion and absorption_Homo sapiens_hsa049751.24791880
51cGMP-PKG signaling pathway_Homo sapiens_hsa040221.23771375
52Cysteine and methionine metabolism_Homo sapiens_hsa002701.20790005
53Oxytocin signaling pathway_Homo sapiens_hsa049211.20049896
54ABC transporters_Homo sapiens_hsa020101.12801575
55Calcium signaling pathway_Homo sapiens_hsa040201.12005425
56Folate biosynthesis_Homo sapiens_hsa007901.10578959
57Aldosterone synthesis and secretion_Homo sapiens_hsa049251.10064567
58Renin secretion_Homo sapiens_hsa049241.09410432
59Maturity onset diabetes of the young_Homo sapiens_hsa049501.08086972
60Insulin secretion_Homo sapiens_hsa049111.00374370
61Arginine and proline metabolism_Homo sapiens_hsa003301.00229737
62Sulfur relay system_Homo sapiens_hsa041220.99675794
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.96313835
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.95953989
65Lysine degradation_Homo sapiens_hsa003100.86866025
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.85861333
67Cyanoamino acid metabolism_Homo sapiens_hsa004600.83780626
68Glycerolipid metabolism_Homo sapiens_hsa005610.79580258
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.78125575
70Arachidonic acid metabolism_Homo sapiens_hsa005900.77982864
71Gastric acid secretion_Homo sapiens_hsa049710.73704934
72Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.73185491
73FoxO signaling pathway_Homo sapiens_hsa040680.67272894
74Steroid biosynthesis_Homo sapiens_hsa001000.63529194
75Vitamin digestion and absorption_Homo sapiens_hsa049770.63388877
76Pentose phosphate pathway_Homo sapiens_hsa000300.62662563
77Dorso-ventral axis formation_Homo sapiens_hsa043200.61383805
78Fatty acid biosynthesis_Homo sapiens_hsa000610.61099136
79cAMP signaling pathway_Homo sapiens_hsa040240.60655362
80Circadian entrainment_Homo sapiens_hsa047130.58112003
81Vitamin B6 metabolism_Homo sapiens_hsa007500.58005052
82Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57664552
83Glutathione metabolism_Homo sapiens_hsa004800.55274782
84mTOR signaling pathway_Homo sapiens_hsa041500.55227656
85Insulin resistance_Homo sapiens_hsa049310.52504090
86* Metabolic pathways_Homo sapiens_hsa011000.50743036
87Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.49599548
88Cholinergic synapse_Homo sapiens_hsa047250.49155395
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48269038
90Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.47961725
91Salivary secretion_Homo sapiens_hsa049700.47174904
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.46876708
93Galactose metabolism_Homo sapiens_hsa000520.46726593
94Serotonergic synapse_Homo sapiens_hsa047260.46465391
95Pancreatic secretion_Homo sapiens_hsa049720.45118534
96Platelet activation_Homo sapiens_hsa046110.44969502
97Morphine addiction_Homo sapiens_hsa050320.44472689
98Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.43748697
99Tight junction_Homo sapiens_hsa045300.43104143
100GnRH signaling pathway_Homo sapiens_hsa049120.42764751
101Fructose and mannose metabolism_Homo sapiens_hsa000510.41094303
102Inositol phosphate metabolism_Homo sapiens_hsa005620.40682742
103Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.38213657
104Glucagon signaling pathway_Homo sapiens_hsa049220.37678912
105Taste transduction_Homo sapiens_hsa047420.37588202
106One carbon pool by folate_Homo sapiens_hsa006700.37369444
107GABAergic synapse_Homo sapiens_hsa047270.37278173
108MAPK signaling pathway_Homo sapiens_hsa040100.35032796
109Parkinsons disease_Homo sapiens_hsa050120.31421222
110Oxidative phosphorylation_Homo sapiens_hsa001900.31307223
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.30509265
112Prion diseases_Homo sapiens_hsa050200.24844647
113* AMPK signaling pathway_Homo sapiens_hsa041520.19241891
114Alzheimers disease_Homo sapiens_hsa050100.18380978
115Cardiac muscle contraction_Homo sapiens_hsa042600.17589641
116alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.16680133
117Insulin signaling pathway_Homo sapiens_hsa049100.16477408
118Glycerophospholipid metabolism_Homo sapiens_hsa005640.15489696
119Linoleic acid metabolism_Homo sapiens_hsa005910.08903068
120Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1261151
121Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1248024
122Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1245767
123Type II diabetes mellitus_Homo sapiens_hsa04930-0.1000776
124Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.0971385
125Regulation of autophagy_Homo sapiens_hsa04140-0.0893951
126Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.0712273
127Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0708829
128Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0617645
129Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0615132
130Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410-0.0609171
131Dilated cardiomyopathy_Homo sapiens_hsa05414-0.0576836
132Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0538388
133Huntingtons disease_Homo sapiens_hsa05016-0.0470728
134Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0358919
135Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.0319523

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