MLLT4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)5.23068233
2hemidesmosome assembly (GO:0031581)4.56128032
3bundle of His cell to Purkinje myocyte communication (GO:0086069)4.21173897
4regulation of cardioblast differentiation (GO:0051890)3.68257183
5hippo signaling (GO:0035329)3.62059792
6paraxial mesoderm development (GO:0048339)3.60655003
7regulation of hippo signaling (GO:0035330)3.59243252
8cytoskeletal anchoring at plasma membrane (GO:0007016)3.54722878
9polarized epithelial cell differentiation (GO:0030859)3.38421090
10plasma membrane repair (GO:0001778)3.28967598
11epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.27568172
12cilium or flagellum-dependent cell motility (GO:0001539)3.25462336
13establishment of apical/basal cell polarity (GO:0035089)3.23028860
14axonemal dynein complex assembly (GO:0070286)3.20631664
15embryonic foregut morphogenesis (GO:0048617)3.19145516
16negative regulation of cell fate specification (GO:0009996)3.06345141
17gastrulation with mouth forming second (GO:0001702)3.00377235
18camera-type eye morphogenesis (GO:0048593)3.00025594
19negative regulation of catenin import into nucleus (GO:0035414)2.98882292
20lateral sprouting from an epithelium (GO:0060601)2.98619832
21regulation of cardioblast proliferation (GO:0003264)2.95457082
22regulation of secondary heart field cardioblast proliferation (GO:0003266)2.95457082
23epithelial cell-cell adhesion (GO:0090136)2.92819531
24pre-miRNA processing (GO:0031054)2.91734424
25planar cell polarity pathway involved in neural tube closure (GO:0090179)2.90465880
26dorsal/ventral axis specification (GO:0009950)2.89220541
27ectoderm development (GO:0007398)2.88873560
28establishment of planar polarity (GO:0001736)2.87370230
29establishment of tissue polarity (GO:0007164)2.87370230
30cell-substrate junction assembly (GO:0007044)2.86095763
31cytoplasmic mRNA processing body assembly (GO:0033962)2.85380308
32establishment or maintenance of monopolar cell polarity (GO:0061339)2.85136215
33establishment of monopolar cell polarity (GO:0061162)2.85136215
34establishment of nucleus localization (GO:0040023)2.84917922
35convergent extension (GO:0060026)2.84753843
36ventricular cardiac muscle cell action potential (GO:0086005)2.84517277
37intestinal epithelial cell development (GO:0060576)2.84255710
38layer formation in cerebral cortex (GO:0021819)2.83556418
39cell migration involved in sprouting angiogenesis (GO:0002042)2.82554195
40asymmetric protein localization (GO:0008105)2.82296961
41insulin-like growth factor receptor signaling pathway (GO:0048009)2.80656353
42cilium movement (GO:0003341)2.80306950
43regulation of gene silencing by miRNA (GO:0060964)2.77722340
44regulation of gene silencing by RNA (GO:0060966)2.77722340
45regulation of posttranscriptional gene silencing (GO:0060147)2.77722340
46anterior/posterior axis specification, embryo (GO:0008595)2.77458285
47cell communication involved in cardiac conduction (GO:0086065)2.74957861
48regulation of catenin import into nucleus (GO:0035412)2.74487972
49lung epithelium development (GO:0060428)2.74431974
50regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.74154449
51dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.73896320
52atrioventricular valve morphogenesis (GO:0003181)2.73365558
53regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.72207916
54neuronal stem cell maintenance (GO:0097150)2.71551134
55regulation of cell fate specification (GO:0042659)2.69923666
56neuron recognition (GO:0008038)2.69733680
57adherens junction assembly (GO:0034333)2.69154032
58lymph vessel development (GO:0001945)2.67396958
59axonal fasciculation (GO:0007413)2.66181756
60cell junction maintenance (GO:0034331)2.65217777
61regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.63210638
62Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.61415923
63notochord development (GO:0030903)2.61410452
64endocardial cushion development (GO:0003197)2.60523194
65limb bud formation (GO:0060174)2.59850508
66establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.59644674
67body morphogenesis (GO:0010171)2.56754494
68G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.55598706
69pyrimidine nucleobase catabolic process (GO:0006208)2.55354439
70positive regulation of dendritic spine morphogenesis (GO:0061003)2.53711941
71mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.53624296
72regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.53276139
73regulation of water loss via skin (GO:0033561)2.53115927
74regulation of heart morphogenesis (GO:2000826)2.51936422
75regulation of establishment of planar polarity (GO:0090175)2.51518605
76regulation of non-canonical Wnt signaling pathway (GO:2000050)2.48400326
77glial cell proliferation (GO:0014009)2.47330681
78embryonic retina morphogenesis in camera-type eye (GO:0060059)2.43740720
79morphogenesis of an epithelial sheet (GO:0002011)2.42977674
80lung-associated mesenchyme development (GO:0060484)2.41985920
81regulation of NFAT protein import into nucleus (GO:0051532)2.40643576
82regulation of p38MAPK cascade (GO:1900744)2.40069529
83cerebral cortex radially oriented cell migration (GO:0021799)2.38565142
84apical protein localization (GO:0045176)2.38505609
85retina vasculature morphogenesis in camera-type eye (GO:0061299)2.37904081
86* adherens junction organization (GO:0034332)2.37430896
87lymphangiogenesis (GO:0001946)2.36741686
88epithelial cilium movement (GO:0003351)2.35834303
89establishment of skin barrier (GO:0061436)2.34617482
90nucleus localization (GO:0051647)2.34555249
91presynaptic membrane assembly (GO:0097105)2.34468948
92cell migration involved in gastrulation (GO:0042074)2.33999011
93regulation of RNA export from nucleus (GO:0046831)2.33173227
94basement membrane organization (GO:0071711)2.32616203
95coronary vasculature morphogenesis (GO:0060977)2.32541953
96heart morphogenesis (GO:0003007)2.32099903
97regulation of transforming growth factor beta2 production (GO:0032909)2.31726102
98regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.29626256
99myelination in peripheral nervous system (GO:0022011)2.29538655
100peripheral nervous system axon ensheathment (GO:0032292)2.29538655
101positive regulation of SMAD protein import into nucleus (GO:0060391)2.28998743
102axon extension involved in axon guidance (GO:0048846)2.28824414
103neuron projection extension involved in neuron projection guidance (GO:1902284)2.28824414
104cell surface receptor signaling pathway involved in heart development (GO:0061311)2.28249539
105renal system development (GO:0072001)2.27561306
106motile cilium assembly (GO:0044458)2.27286936
107focal adhesion assembly (GO:0048041)2.27244603
108cell-substrate adherens junction assembly (GO:0007045)2.27244603
109renal filtration (GO:0097205)2.27093603
110branching involved in salivary gland morphogenesis (GO:0060445)2.26939824
111regulation of heart rate by cardiac conduction (GO:0086091)2.26877437
112gap junction assembly (GO:0016264)2.26752403
113non-canonical Wnt signaling pathway (GO:0035567)2.26342453
114establishment of epithelial cell polarity (GO:0090162)2.25167315
115ectodermal placode formation (GO:0060788)2.24736092
116negative regulation of keratinocyte proliferation (GO:0010839)2.24515864
117neural tube development (GO:0021915)2.24487787
118presynaptic membrane organization (GO:0097090)2.24167521
119negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.23436525
120stress granule assembly (GO:0034063)2.23329666
121regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.22887471
122protein localization to endosome (GO:0036010)2.22501419
123chemical homeostasis within a tissue (GO:0048875)2.22409149
124epithelial cell differentiation involved in prostate gland development (GO:0060742)2.22297268
125post-anal tail morphogenesis (GO:0036342)2.22233857
126semaphorin-plexin signaling pathway (GO:0071526)2.21765825
127ephrin receptor signaling pathway (GO:0048013)2.21617119
128positive regulation of catenin import into nucleus (GO:0035413)2.21269294
129regulation of clathrin-mediated endocytosis (GO:2000369)2.20206694
130blood vessel endothelial cell migration (GO:0043534)2.20200458
131collecting duct development (GO:0072044)2.19965525
132positive regulation of smoothened signaling pathway (GO:0045880)2.19781202
133cell-cell junction maintenance (GO:0045217)2.19626862
134establishment or maintenance of apical/basal cell polarity (GO:0035088)2.19062163
135establishment or maintenance of bipolar cell polarity (GO:0061245)2.19062163
136NLS-bearing protein import into nucleus (GO:0006607)2.18787911
137heart valve formation (GO:0003188)2.18673053
138nuclear pore complex assembly (GO:0051292)2.18481037
139embryonic body morphogenesis (GO:0010172)2.18401069
140regulation of axon extension involved in axon guidance (GO:0048841)2.18211399
141regulation of neuron migration (GO:2001222)2.18105847
142cell migration in hindbrain (GO:0021535)2.17359477
143negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.16511590
144negative regulation of translation, ncRNA-mediated (GO:0040033)2.16511590
145regulation of translation, ncRNA-mediated (GO:0045974)2.16511590
146cardiac myofibril assembly (GO:0055003)2.15984010
147vascular endothelial growth factor signaling pathway (GO:0038084)2.15621496
148regulation of growth hormone secretion (GO:0060123)2.14671646
149dendrite morphogenesis (GO:0048813)2.13566303
150central nervous system projection neuron axonogenesis (GO:0021952)2.12974458
151histone H3-K9 demethylation (GO:0033169)2.08105431
152neural tube closure (GO:0001843)2.07803059
153cochlea morphogenesis (GO:0090103)2.07441349
154regulation of axon guidance (GO:1902667)2.06493149
155tube closure (GO:0060606)2.05532358
156nucleobase catabolic process (GO:0046113)2.05316236
157spinal cord development (GO:0021510)2.04993321
158lens morphogenesis in camera-type eye (GO:0002089)2.02758691
159neurotransmitter-gated ion channel clustering (GO:0072578)2.02647818
160lens fiber cell development (GO:0070307)2.00935836
161hindbrain development (GO:0030902)2.00902889

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.09466245
2EZH2_22144423_ChIP-Seq_EOC_Human2.81230159
3SALL1_21062744_ChIP-ChIP_HESCs_Human2.66032766
4SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.41427187
5ZNF263_19887448_ChIP-Seq_K562_Human2.11410264
6STAT6_21828071_ChIP-Seq_BEAS2B_Human2.05773020
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.03442121
8ZNF217_24962896_ChIP-Seq_MCF-7_Human2.00747894
9TRIM28_21343339_ChIP-Seq_HEK293_Human1.97412352
10NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.94871924
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.91376572
12ESR1_21235772_ChIP-Seq_MCF-7_Human1.88938786
13* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.88290004
14GBX2_23144817_ChIP-Seq_PC3_Human1.83206371
15ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.83113471
16ESR2_21235772_ChIP-Seq_MCF-7_Human1.80705776
17SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.79288132
18KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.77392285
19KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.77392285
20KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.77392285
21CLOCK_20551151_ChIP-Seq_293T_Human1.75473553
22TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.73021424
23* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.72322951
24SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.64016245
25CBX2_27304074_Chip-Seq_ESCs_Mouse1.63626430
26FOXO3_23340844_ChIP-Seq_DLD1_Human1.62592804
27* ISL1_27105846_Chip-Seq_CPCs_Mouse1.62433854
28HIF1A_21447827_ChIP-Seq_MCF-7_Human1.61804233
29RNF2_18974828_ChIP-Seq_MESCs_Mouse1.59062047
30EZH2_18974828_ChIP-Seq_MESCs_Mouse1.59062047
31EZH2_27304074_Chip-Seq_ESCs_Mouse1.58398257
32HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.56650359
33WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.55901781
34ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.54909638
35EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.54830994
36NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.53165856
37TCF4_18268006_ChIP-ChIP_LS174T_Human1.52174195
38* EP300_21415370_ChIP-Seq_HL-1_Mouse1.51806101
39TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.50980383
40ESR1_15608294_ChIP-ChIP_MCF-7_Human1.50536419
41EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.50134552
42AHR_22903824_ChIP-Seq_MCF-7_Human1.50115323
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.49643806
44ZFP281_18757296_ChIP-ChIP_E14_Mouse1.44808838
45RNF2_27304074_Chip-Seq_ESCs_Mouse1.44266097
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43203121
47YAP1_20516196_ChIP-Seq_MESCs_Mouse1.42705224
48ZFP281_27345836_Chip-Seq_ESCs_Mouse1.42346473
49ESR1_20079471_ChIP-ChIP_T-47D_Human1.42042353
50KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.40029235
51EED_16625203_ChIP-ChIP_MESCs_Mouse1.38294625
52NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.38283247
53JARID2_20064375_ChIP-Seq_MESCs_Mouse1.36355673
54TP53_16413492_ChIP-PET_HCT116_Human1.36082000
55PPAR_26484153_Chip-Seq_NCI-H1993_Human1.34629829
56TCF3_18692474_ChIP-Seq_MEFs_Mouse1.34516029
57TCF3_18692474_ChIP-Seq_MESCs_Mouse1.34153133
58TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33419608
59CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.31586113
60AR_21572438_ChIP-Seq_LNCaP_Human1.30120199
61KDM2B_26808549_Chip-Seq_K562_Human1.28674846
62HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.28426936
63SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.28337769
64FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.27909294
65DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.26712014
66RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.26126291
67* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.24379068
68* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.24379068
69ARNT_22903824_ChIP-Seq_MCF-7_Human1.24100468
70WT1_19549856_ChIP-ChIP_CCG9911_Human1.24065383
71MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.23278029
72RUNX1_27514584_Chip-Seq_MCF-7_Human1.23179902
73TAF15_26573619_Chip-Seq_HEK293_Human1.22834486
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.22830721
75RARG_19884340_ChIP-ChIP_MEFs_Mouse1.22289818
76AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21743716
77TP63_19390658_ChIP-ChIP_HaCaT_Human1.21474032
78PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.20792152
79NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.20744932
80RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.20634308
81CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.20494816
82RING1B_27294783_Chip-Seq_ESCs_Mouse1.20369429
83ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.19968253
84TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.19291841
85SMAD4_21799915_ChIP-Seq_A2780_Human1.18085082
86ERG_21242973_ChIP-ChIP_JURKAT_Human1.17331980
87KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.16807425
88STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.16612115
89POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16580406
90TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16580406
91CDX2_20551321_ChIP-Seq_CACO-2_Human1.16099520
92P300_27058665_Chip-Seq_ZR-75-30cells_Human1.15217437
93SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.14923364
94SALL4_18804426_ChIP-ChIP_XEN_Mouse1.14771218
95JARID2_20075857_ChIP-Seq_MESCs_Mouse1.14703610
96AR_21909140_ChIP-Seq_LNCAP_Human1.14327912
97* RNF2_27304074_Chip-Seq_NSC_Mouse1.14143762
98GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.13649699
99* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.13402541
100* FOXA2_19822575_ChIP-Seq_HepG2_Human1.13134972
101RBPJ_22232070_ChIP-Seq_NCS_Mouse1.12295083
102EZH2_27294783_Chip-Seq_ESCs_Mouse1.12132732
103GATA1_26923725_Chip-Seq_HPCs_Mouse1.11295717
104SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.08886371
105SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.08875047
106BMI1_23680149_ChIP-Seq_NPCS_Mouse1.08211941
107SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.07726316
108CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.07646918
109SOX2_27498859_Chip-Seq_STOMACH_Mouse1.07565729
110PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.07369320
111RING1B_27294783_Chip-Seq_NPCs_Mouse1.06919971
112ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06661480
113KLF5_25053715_ChIP-Seq_YYC3_Human1.06619063
114* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.06480838
115POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.05727615
116SMAD4_21741376_ChIP-Seq_HESCs_Human1.05403416
117TBX3_20139965_ChIP-Seq_ESCs_Mouse1.05379914
118TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05194930
119TBX3_20139965_ChIP-Seq_MESCs_Mouse1.05068601
120SMAD3_21741376_ChIP-Seq_HESCs_Human1.04862399
121SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.04713504
122PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.04415902
123CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04379070
124FUS_26573619_Chip-Seq_HEK293_Human1.04220217
125* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.03927433
126STAT3_23295773_ChIP-Seq_U87_Human1.03847182
127AR_19668381_ChIP-Seq_PC3_Human1.03688040
128TBX20_22080862_ChIP-Seq_HEART_Mouse1.03495480
129TBX20_22328084_ChIP-Seq_HEART_Mouse1.03495480
130ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.03323128
131LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03242834
132GATA6_25053715_ChIP-Seq_YYC3_Human1.03235883
133KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.03082251
134FOXM1_23109430_ChIP-Seq_U2OS_Human1.03053374
135ATF3_27146783_Chip-Seq_COLON_Human1.02592266
136* CJUN_26792858_Chip-Seq_BT549_Human1.02198546
137STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.01758854
138SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01701486
139LXR_22158963_ChIP-Seq_LIVER_Mouse1.00944716
140RXR_22108803_ChIP-Seq_LS180_Human1.00415271
141DROSHA_22980978_ChIP-Seq_HELA_Human1.00318591
142CTNNB1_20460455_ChIP-Seq_HCT116_Human0.99635166
143TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.99618615
144CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99471074
145RACK7_27058665_Chip-Seq_MCF-7_Human0.99324057
146FOXM1_26456572_ChIP-Seq_MCF-7_Human0.98468549
147POU5F1_16518401_ChIP-PET_MESCs_Mouse0.98380463
148SUZ12_27294783_Chip-Seq_ESCs_Mouse0.98328077
149CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.98173923
150SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.97635097
151POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.96628405
152NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.95940318
153PIAS1_25552417_ChIP-Seq_VCAP_Human0.94542201
154FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.93181918
155BCAT_22108803_ChIP-Seq_LS180_Human0.93062121

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle5.00267727
2MP0003705_abnormal_hypodermis_morpholog3.80690336
3MP0000537_abnormal_urethra_morphology2.95498223
4MP0002796_impaired_skin_barrier2.77795231
5MP0003941_abnormal_skin_development2.58677962
6MP0004272_abnormal_basement_membrane2.47770263
7MP0005275_abnormal_skin_tensile2.47490964
8MP0010678_abnormal_skin_adnexa2.34453922
9MP0000778_abnormal_nervous_system2.33902874
10MP0003122_maternal_imprinting2.28257177
11MP0000579_abnormal_nail_morphology2.04876030
12MP0005623_abnormal_meninges_morphology2.01325314
13MP0001849_ear_inflammation1.91147767
14MP0010030_abnormal_orbit_morphology1.88594786
15MP0003566_abnormal_cell_adhesion1.83224014
16MP0005076_abnormal_cell_differentiation1.79590301
17MP0004185_abnormal_adipocyte_glucose1.78831593
18MP0002098_abnormal_vibrissa_morphology1.77786820
19MP0000383_abnormal_hair_follicle1.69523912
20MP0005187_abnormal_penis_morphology1.68976306
21MP0010352_gastrointestinal_tract_polyps1.67098634
22MP0005409_darkened_coat_color1.66754490
23MP0005501_abnormal_skin_physiology1.66270033
24MP0003942_abnormal_urinary_system1.65648743
25MP0004270_analgesia1.63479655
26MP0003119_abnormal_digestive_system1.63153848
27MP0005377_hearing/vestibular/ear_phenot1.60752199
28MP0003878_abnormal_ear_physiology1.60752199
29MP0004264_abnormal_extraembryonic_tissu1.60133931
30MP0009053_abnormal_anal_canal1.53107363
31MP0003890_abnormal_embryonic-extraembry1.51971983
32MP0010368_abnormal_lymphatic_system1.51416372
33MP0005248_abnormal_Harderian_gland1.49615411
34MP0002234_abnormal_pharynx_morphology1.48334041
35MP0003283_abnormal_digestive_organ1.48103373
36* MP0003861_abnormal_nervous_system1.46972718
37MP0001286_abnormal_eye_development1.38895055
38MP0000569_abnormal_digit_pigmentation1.37925150
39MP0002254_reproductive_system_inflammat1.33074910
40MP0004084_abnormal_cardiac_muscle1.32255836
41MP0005367_renal/urinary_system_phenotyp1.31584190
42MP0000516_abnormal_urinary_system1.31584190
43MP0005666_abnormal_adipose_tissue1.29663665
44MP0003115_abnormal_respiratory_system1.29450570
45MP0003938_abnormal_ear_development1.29360366
46MP0004859_abnormal_synaptic_plasticity1.29261359
47MP0009780_abnormal_chondrocyte_physiolo1.27643810
48MP0000647_abnormal_sebaceous_gland1.27301074
49MP0003937_abnormal_limbs/digits/tail_de1.25342641
50MP0002060_abnormal_skin_morphology1.23254251
51MP0000049_abnormal_middle_ear1.23062408
52MP0003136_yellow_coat_color1.22592610
53MP0002697_abnormal_eye_size1.22326082
54MP0003935_abnormal_craniofacial_develop1.21786794
55MP0000467_abnormal_esophagus_morphology1.20498546
56MP0000955_abnormal_spinal_cord1.20372878
57MP0003385_abnormal_body_wall1.19783041
58MP0006292_abnormal_olfactory_placode1.19638397
59MP0000762_abnormal_tongue_morphology1.19195786
60MP0003453_abnormal_keratinocyte_physiol1.18812671
61MP0003950_abnormal_plasma_membrane1.18453418
62MP0003567_abnormal_fetal_cardiomyocyte1.17500845
63* MP0002084_abnormal_developmental_patter1.17462850
64MP0002938_white_spotting1.16362071
65MP0006138_congestive_heart_failure1.15827578
66MP0001984_abnormal_olfaction1.13468564
67MP0000534_abnormal_ureter_morphology1.12271682
68MP0000377_abnormal_hair_follicle1.12211219
69MP0004197_abnormal_fetal_growth/weight/1.10962592
70MP0003755_abnormal_palate_morphology1.10312257
71MP0002249_abnormal_larynx_morphology1.10222021
72MP0002184_abnormal_innervation1.09908992
73MP0004885_abnormal_endolymph1.09227371
74MP0000733_abnormal_muscle_development1.08660760
75MP0002116_abnormal_craniofacial_bone1.08080879
76MP0000631_abnormal_neuroendocrine_gland1.06342233
77MP0005499_abnormal_olfactory_system1.05266895
78MP0005394_taste/olfaction_phenotype1.05266895
79MP0002152_abnormal_brain_morphology1.04943696
80MP0005375_adipose_tissue_phenotype1.04561926
81MP0001216_abnormal_epidermal_layer1.03979936
82MP0010630_abnormal_cardiac_muscle1.02866619
83MP0005167_abnormal_blood-brain_barrier0.98989443
84MP0005257_abnormal_intraocular_pressure0.98738923
85MP0000462_abnormal_digestive_system0.97893448
86MP0003315_abnormal_perineum_morphology0.97718733
87MP0002233_abnormal_nose_morphology0.97014316
88MP0004043_abnormal_pH_regulation0.96808423
89MP0002896_abnormal_bone_mineralization0.95369467
90MP0000751_myopathy0.95295840
91MP0009384_cardiac_valve_regurgitation0.94895963
92MP0009672_abnormal_birth_weight0.94630317
93MP0002909_abnormal_adrenal_gland0.94627681
94MP0000566_synostosis0.94241035
95* MP0002086_abnormal_extraembryonic_tissu0.93940119
96MP0002081_perinatal_lethality0.93890258
97MP0004087_abnormal_muscle_fiber0.93482794
98MP0000678_abnormal_parathyroid_gland0.93471187
99MP0002089_abnormal_postnatal_growth/wei0.92964720
100MP0004233_abnormal_muscle_weight0.92734955
101MP0010771_integument_phenotype0.92613131
102MP0001188_hyperpigmentation0.90768109
103* MP0002925_abnormal_cardiovascular_devel0.90472400
104MP0004215_abnormal_myocardial_fiber0.90111507
105MP0000427_abnormal_hair_cycle0.89785193
106MP0008789_abnormal_olfactory_epithelium0.88622408
107MP0000432_abnormal_head_morphology0.88582974
108MP0002092_abnormal_eye_morphology0.88567477
109MP0000428_abnormal_craniofacial_morphol0.88412597
110MP0000003_abnormal_adipose_tissue0.88161031
111MP0002088_abnormal_embryonic_growth/wei0.87598895
112MP0002877_abnormal_melanocyte_morpholog0.87449151
113MP0003123_paternal_imprinting0.87444488
114MP0001879_abnormal_lymphatic_vessel0.87219868
115* MP0002085_abnormal_embryonic_tissue0.87133369
116MP0001672_abnormal_embryogenesis/_devel0.85974117
117MP0005380_embryogenesis_phenotype0.85974117
118MP0001299_abnormal_eye_distance/0.85784302
119MP0003984_embryonic_growth_retardation0.85464385
120MP0003252_abnormal_bile_duct0.85381926
121MP0003121_genomic_imprinting0.85046694
122MP0001666_abnormal_nutrient_absorption0.84846673
123MP0002557_abnormal_social/conspecific_i0.84700580
124MP0001346_abnormal_lacrimal_gland0.84555232
125MP0003045_fibrosis0.83700252
126MP0003868_abnormal_feces_composition0.83023425
127* MP0002882_abnormal_neuron_morphology0.82586069
128MP0002653_abnormal_ependyma_morphology0.81675974
129MP0002837_dystrophic_cardiac_calcinosis0.81427147
130MP0002734_abnormal_mechanical_nocicepti0.80681761
131MP0004858_abnormal_nervous_system0.80650935
132MP0009379_abnormal_foot_pigmentation0.79896156
133MP0004133_heterotaxia0.79207147
134MP0004130_abnormal_muscle_cell0.78517472
135MP0003091_abnormal_cell_migration0.77983650
136MP0002111_abnormal_tail_morphology0.77963760
137MP0001915_intracranial_hemorrhage0.77258290
138MP0009703_decreased_birth_body0.76019720
139MP0001293_anophthalmia0.75493149
140MP0003300_gastrointestinal_ulcer0.75489519
141MP0002139_abnormal_hepatobiliary_system0.75442443
142MP0005391_vision/eye_phenotype0.74938664
143MP0001784_abnormal_fluid_regulation0.74114250

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)4.71979777
2Shallow orbits (HP:0000586)3.01024881
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.01011884
4Milia (HP:0001056)2.79423427
5Hyporeflexia of lower limbs (HP:0002600)2.76641295
6Neonatal short-limb short stature (HP:0008921)2.70685223
7Woolly hair (HP:0002224)2.62918500
8Vertebral arch anomaly (HP:0008438)2.52062963
9Cutaneous syndactyly (HP:0012725)2.49837920
10Atrophic scars (HP:0001075)2.48249111
11Abnormal respiratory motile cilium physiology (HP:0012261)2.46196917
12Abnormal respiratory epithelium morphology (HP:0012253)2.45827142
13Abnormal respiratory motile cilium morphology (HP:0005938)2.45827142
14Bronchomalacia (HP:0002780)2.44435869
15Increased connective tissue (HP:0009025)2.42832822
16Abnormal ciliary motility (HP:0012262)2.42466850
17Sudden death (HP:0001699)2.41241508
18Onycholysis (HP:0001806)2.41183745
19Absent/shortened dynein arms (HP:0200106)2.40900623
20Dynein arm defect of respiratory motile cilia (HP:0012255)2.40900623
21Midline defect of the nose (HP:0004122)2.40556150
22Chronic bronchitis (HP:0004469)2.39545003
23Ventricular tachycardia (HP:0004756)2.39179670
24Rhinitis (HP:0012384)2.38317057
25Subacute progressive viral hepatitis (HP:0006572)2.37516434
26Difficulty running (HP:0009046)2.37040992
27Rectal prolapse (HP:0002035)2.36476563
28Papillary thyroid carcinoma (HP:0002895)2.35608527
29Astrocytoma (HP:0009592)2.31625108
30Abnormality of the astrocytes (HP:0100707)2.31625108
31Hypotrichosis (HP:0001006)2.28913480
32Aplasia involving bones of the upper limbs (HP:0009823)2.21063647
33Aplasia of the phalanges of the hand (HP:0009802)2.21063647
34Aplasia involving bones of the extremities (HP:0009825)2.21063647
35Ependymoma (HP:0002888)2.18436227
36Morphological abnormality of the middle ear (HP:0008609)2.16088494
37Pili torti (HP:0003777)2.15484170
38Bifid scrotum (HP:0000048)2.10318912
39Biliary tract neoplasm (HP:0100574)2.09490843
40Ventricular fibrillation (HP:0001663)2.08399636
41Cerebral aneurysm (HP:0004944)2.08373959
42Absent eyebrow (HP:0002223)2.08051910
43Fragile nails (HP:0001808)2.08043022
44Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.06913048
45Short 4th metacarpal (HP:0010044)2.06913048
46Myelomeningocele (HP:0002475)2.06425704
47High anterior hairline (HP:0009890)2.05788598
48Hypoplastic labia majora (HP:0000059)2.03186570
49Alacrima (HP:0000522)2.02810892
50Esophageal atresia (HP:0002032)2.02672557
51Advanced eruption of teeth (HP:0006288)2.02561909
52Deep venous thrombosis (HP:0002625)2.00136582
53Vitreoretinal degeneration (HP:0000655)1.99151392
54Curly hair (HP:0002212)1.99135879
55Omphalocele (HP:0001539)1.98439399
56Anophthalmia (HP:0000528)1.97478395
57Lymphangioma (HP:0100764)1.93425309
58Broad palm (HP:0001169)1.93208773
59Gastrointestinal carcinoma (HP:0002672)1.92545241
60Malignant gastrointestinal tract tumors (HP:0006749)1.92545241
61Exotropia (HP:0000577)1.92288760
62Pseudobulbar signs (HP:0002200)1.91537060
63Shawl scrotum (HP:0000049)1.90963742
64Flat acetabular roof (HP:0003180)1.89217507
65Lip pit (HP:0100267)1.88704043
66Aplasia/Hypoplasia of the sternum (HP:0006714)1.88291444
67Partial duplication of thumb phalanx (HP:0009944)1.87650893
68Ankyloglossia (HP:0010296)1.87311057
69Abnormality of the lower motor neuron (HP:0002366)1.86143573
70Elfin facies (HP:0004428)1.85824681
71Acanthosis nigricans (HP:0000956)1.85028842
72Coronal craniosynostosis (HP:0004440)1.84855065
73Choanal stenosis (HP:0000452)1.83960779
74Renal hypoplasia (HP:0000089)1.83151216
75Plantar hyperkeratosis (HP:0007556)1.82720818
76Abnormality of the labia majora (HP:0012881)1.78569231
77Abnormality of the aortic arch (HP:0012303)1.78192376
78Turricephaly (HP:0000262)1.77799696
79Abnormality of the 4th metacarpal (HP:0010012)1.77010544
80Aneurysm (HP:0002617)1.75983755
81Renal duplication (HP:0000075)1.73658561
82Syncope (HP:0001279)1.73422407
83Anal stenosis (HP:0002025)1.73217464
84Obsessive-compulsive behavior (HP:0000722)1.72395701
85Esophageal varix (HP:0002040)1.72228078
86Skull defect (HP:0001362)1.70163087
87Broad metatarsal (HP:0001783)1.69913963
88Skin pits (HP:0100276)1.69711006
89Hepatoblastoma (HP:0002884)1.69648090
90Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.69529797
91Arnold-Chiari malformation (HP:0002308)1.68533238
92Preaxial foot polydactyly (HP:0001841)1.67892613
93Scapular winging (HP:0003691)1.66600552
94Bicornuate uterus (HP:0000813)1.66308876
95Abnormality of the lacrimal duct (HP:0011481)1.66081972
96Facial cleft (HP:0002006)1.65934298
97Muscle fiber splitting (HP:0003555)1.65398719
98Oligodontia (HP:0000677)1.64603301
99Abnormality of the nasal septum (HP:0000419)1.64243095
100Renovascular hypertension (HP:0100817)1.64023987
101Abnormality of permanent molar morphology (HP:0011071)1.63705566
102Abnormality of the dental root (HP:0006486)1.63705566
103Taurodontia (HP:0000679)1.63705566
104Natal tooth (HP:0000695)1.63215247
105Increased nuchal translucency (HP:0010880)1.63133059
106Mildly elevated creatine phosphokinase (HP:0008180)1.63098647
107Colon cancer (HP:0003003)1.62376330
108Decreased lacrimation (HP:0000633)1.62282050
109Macroorchidism (HP:0000053)1.62086981
110Ankle contracture (HP:0006466)1.61823291
111Drooling (HP:0002307)1.61648863
112Cortical dysplasia (HP:0002539)1.61008993
113Abnormality of the pubic bones (HP:0003172)1.60077932
114Hyperacusis (HP:0010780)1.59499558
115Deviation of the thumb (HP:0009603)1.57972452
116Glioma (HP:0009733)1.57949430
117Vertebral clefting (HP:0008428)1.57665707
118Ventricular arrhythmia (HP:0004308)1.57442851
119Enlarged penis (HP:0000040)1.57318563
120Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.56911430
121Osteomalacia (HP:0002749)1.56627077
122Uterine neoplasm (HP:0010784)1.56603567
123Neonatal death (HP:0003811)1.55796518
124Short humerus (HP:0005792)1.55450476
125Back pain (HP:0003418)1.55086609
126Trigonocephaly (HP:0000243)1.54616202
127Hyperactive renin-angiotensin system (HP:0000841)1.54562674
128Labial hypoplasia (HP:0000066)1.54484983
129Abnormality of the gastric mucosa (HP:0004295)1.54443730
13011 pairs of ribs (HP:0000878)1.53935667
131Oligodactyly (HP:0012165)1.53804071
132Laryngomalacia (HP:0001601)1.53704296
133Germ cell neoplasia (HP:0100728)1.53196755
134Hypoplastic ischia (HP:0003175)1.53022108
135Down-sloping shoulders (HP:0200021)1.52565519
136Megalencephaly (HP:0001355)1.52323310
137Tracheomalacia (HP:0002779)1.52124262
138Mitral valve prolapse (HP:0001634)1.52066685
139Fibroma (HP:0010614)1.52047052
140Diastasis recti (HP:0001540)1.52045006
141Abnormality of the distal phalanx of the thumb (HP:0009617)1.51753127
142Bladder carcinoma (HP:0002862)1.51435227
143Bladder neoplasm (HP:0009725)1.51435227
144Leiomyosarcoma (HP:0100243)1.51341268
145Uterine leiomyosarcoma (HP:0002891)1.51341268
146Abnormal pancreas size (HP:0012094)1.51203245
147Aplasia cutis congenita (HP:0001057)1.51201764
148Absent eyelashes (HP:0000561)1.51172847
149Bifid tongue (HP:0010297)1.50107510
150Abnormality of the dental pulp (HP:0006479)1.49767563
151Partial duplication of the phalanx of hand (HP:0009999)1.49606984
152Missing ribs (HP:0000921)1.49407016
153Transitional cell carcinoma of the bladder (HP:0006740)1.49137899
154Insidious onset (HP:0003587)1.49030633
155Termporal pattern (HP:0011008)1.49030633
156Limited elbow extension (HP:0001377)1.48897757
157Oligodactyly (hands) (HP:0001180)1.48605899
158Heterotopia (HP:0002282)1.48603909
159Overgrowth (HP:0001548)1.48479236
160Focal segmental glomerulosclerosis (HP:0000097)1.48137900
161Broad thumb (HP:0011304)1.48014842
162Difficulty climbing stairs (HP:0003551)1.47913895
163Abnormality of the ischium (HP:0003174)1.47737290
164Wide anterior fontanel (HP:0000260)1.47646588
165Hamartoma of the eye (HP:0010568)1.47443683
166Fibrous tissue neoplasm (HP:0012316)1.47304102
167Cutaneous finger syndactyly (HP:0010554)1.47183401
168Arterial tortuosity (HP:0005116)1.47077224
169Enlarged kidneys (HP:0000105)1.46895836
170Severe Myopia (HP:0011003)1.46615525
171Abnormality of the nasolacrimal system (HP:0000614)1.45890369
172Cupped ear (HP:0000378)1.45659522
173Abnormality of molar morphology (HP:0011070)1.45491178
174Abnormality of molar (HP:0011077)1.45491178
175Abnormality of the diencephalon (HP:0010662)1.45044211
176Overriding aorta (HP:0002623)1.44648585
177Septo-optic dysplasia (HP:0100842)1.41993276
178Abnormality of the middle phalanges of the toes (HP:0010183)1.40701085

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS13.82357605
2EPHA22.99286626
3CASK2.97806098
4CDK122.75822830
5RIPK12.64634485
6TNIK2.64073698
7EPHB22.63987022
8FER2.41497447
9LATS22.09474355
10PDGFRA2.03006229
11TTN1.99979480
12PKN21.97469410
13TRIB31.97430186
14MAPK151.84861900
15PTK61.79564790
16CAMK1D1.64014158
17PTK21.54916500
18MET1.54765762
19FGFR21.53810386
20LMTK21.51730903
21STK38L1.51382865
22DDR21.51251517
23CAMK1G1.48924385
24MST1R1.46582236
25MAP3K91.46170171
26TYRO31.39695176
27SIK21.35800804
28TIE11.35412221
29MKNK21.33821449
30PRKD31.31747782
31SIK11.30014900
32MAP3K21.28471924
33MTOR1.27450493
34DMPK1.24791911
35FGFR11.21775523
36ICK1.21719430
37SGK2231.16568179
38SGK4941.16568179
39STK391.16506437
40CDK61.15648455
41STK241.13178980
42RPS6KB21.13174604
43SGK21.11332880
44STK381.11189644
45FRK1.08066774
46ERBB21.06777191
47NEK21.06648750
48OBSCN1.01724382
49PAK31.00932902
50KSR11.00583277
51NEK10.99947859
52ERBB40.98920559
53SCYL20.97954597
54EEF2K0.97131025
55BMX0.94665855
56MKNK10.93549998
57PDGFRB0.91133283
58STK30.90587287
59BRD40.89035805
60PAK60.87770194
61CDC42BPA0.87081964
62WNK30.85193630
63MARK10.82976323
64RET0.82710496
65EPHA30.82426193
66SGK30.81686253
67DYRK20.81185437
68KSR20.80550047
69PAK40.79806179
70MAP3K100.78047330
71AKT30.75864031
72MAP3K40.74902959
73PAK20.74809317
74PIK3CA0.72868108
75ALK0.68678446
76YES10.68319546
77MAP3K70.66736717
78CSNK1E0.65520820
79PHKG20.65296186
80PHKG10.65296186
81AKT20.64221637
82ROCK10.63542531
83BRSK20.63360065
84WNK10.63238677
85TTK0.62689952
86DAPK20.62673514
87CSNK1D0.60776633
88NME10.60170919
89INSRR0.59875679
90SGK10.58725052
91MINK10.58468483
92STK110.58275234
93CDK90.55713174
94ERBB30.55638108
95TGFBR10.55356953
96PDK30.55349361
97PDK40.55349361
98PRKAA10.55004130
99MAP2K40.55002579
100MAPK100.53470815
101PRKD10.53412445
102CDK30.53163058
103PRKCI0.51353732
104GSK3A0.51236455
105MELK0.51149718
106DYRK1B0.50929956
107* GSK3B0.50787059
108* PRKDC0.50327471
109PRKCZ0.50289833
110MAP2K10.50132452
111PRKAA20.49353977
112PNCK0.49130832
113MAPKAPK30.47940159
114CSNK1A1L0.47910885
115EPHA40.47885746
116* CDK10.47621875
117MAP3K60.47590024
118CSNK1G20.47128112
119* ATM0.46802696
120TRPM70.45823811
121CDK50.45316441
122CDC70.44296111
123FGFR30.44002115
124MAP3K30.43886511
125MARK20.42982213
126NTRK20.42520037
127NTRK30.42333147
128FGFR40.41887789
129* CDK20.41826448
130PRKCG0.41803685
131NUAK10.41376692
132NLK0.40321937
133RPS6KB10.39729034
134WNK40.38630174
135NTRK10.38548511
136TAOK10.38548441
137CSNK1G10.38310774
138CHEK10.38037676
139DYRK1A0.37120969
140RPS6KA30.36241116
141MAP2K70.36031572

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052172.28630898
2* Adherens junction_Homo sapiens_hsa045202.21601518
3Nitrogen metabolism_Homo sapiens_hsa009102.20728142
4Hippo signaling pathway_Homo sapiens_hsa043902.18117183
5Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.17980023
6* Tight junction_Homo sapiens_hsa045302.04304516
7Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.87786111
8ECM-receptor interaction_Homo sapiens_hsa045121.70866829
9Lysine degradation_Homo sapiens_hsa003101.64582720
10Proteoglycans in cancer_Homo sapiens_hsa052051.59926141
11Hedgehog signaling pathway_Homo sapiens_hsa043401.59158068
12Histidine metabolism_Homo sapiens_hsa003401.53627330
13Dilated cardiomyopathy_Homo sapiens_hsa054141.53251555
14Focal adhesion_Homo sapiens_hsa045101.52739666
15Dorso-ventral axis formation_Homo sapiens_hsa043201.52222102
16Axon guidance_Homo sapiens_hsa043601.51264294
17Steroid biosynthesis_Homo sapiens_hsa001001.45159536
18Arginine biosynthesis_Homo sapiens_hsa002201.41012996
19Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.40439703
20Nicotine addiction_Homo sapiens_hsa050331.38954023
21Fatty acid biosynthesis_Homo sapiens_hsa000611.38832157
22Melanogenesis_Homo sapiens_hsa049161.37471194
23Bladder cancer_Homo sapiens_hsa052191.36226335
24Endometrial cancer_Homo sapiens_hsa052131.36147610
25Complement and coagulation cascades_Homo sapiens_hsa046101.35411074
26MicroRNAs in cancer_Homo sapiens_hsa052061.35043372
27Phenylalanine metabolism_Homo sapiens_hsa003601.34859361
28Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.31820357
29Bile secretion_Homo sapiens_hsa049761.28363815
30TGF-beta signaling pathway_Homo sapiens_hsa043501.26198658
31Wnt signaling pathway_Homo sapiens_hsa043101.21573237
32Retinol metabolism_Homo sapiens_hsa008301.18042509
33Small cell lung cancer_Homo sapiens_hsa052221.15489821
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.14797361
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.14131180
36Fat digestion and absorption_Homo sapiens_hsa049751.12264085
37mTOR signaling pathway_Homo sapiens_hsa041501.11486677
38Insulin resistance_Homo sapiens_hsa049311.09613555
39Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.08057233
40Central carbon metabolism in cancer_Homo sapiens_hsa052301.06133312
41Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.04584768
42AMPK signaling pathway_Homo sapiens_hsa041521.04542564
43Estrogen signaling pathway_Homo sapiens_hsa049151.03996423
44Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.03630145
45Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.03395819
46Type II diabetes mellitus_Homo sapiens_hsa049301.03195372
47Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.01893770
48Thyroid hormone signaling pathway_Homo sapiens_hsa049191.01231182
49PPAR signaling pathway_Homo sapiens_hsa033201.01200328
50GnRH signaling pathway_Homo sapiens_hsa049120.99447770
51Glucagon signaling pathway_Homo sapiens_hsa049220.98626548
52Fatty acid degradation_Homo sapiens_hsa000710.98197493
53Amoebiasis_Homo sapiens_hsa051460.98172868
54Glutamatergic synapse_Homo sapiens_hsa047240.97530384
55Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.97297914
56Tyrosine metabolism_Homo sapiens_hsa003500.97051108
57Protein digestion and absorption_Homo sapiens_hsa049740.94064298
58Glioma_Homo sapiens_hsa052140.93681279
59Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.93112840
60mRNA surveillance pathway_Homo sapiens_hsa030150.89617107
61Pentose and glucuronate interconversions_Homo sapiens_hsa000400.89596330
62ABC transporters_Homo sapiens_hsa020100.89542137
63* Rap1 signaling pathway_Homo sapiens_hsa040150.89357012
64Fatty acid metabolism_Homo sapiens_hsa012120.89340667
65Starch and sucrose metabolism_Homo sapiens_hsa005000.89208058
66Notch signaling pathway_Homo sapiens_hsa043300.89056980
67Gap junction_Homo sapiens_hsa045400.88449895
68Insulin signaling pathway_Homo sapiens_hsa049100.88108255
69Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.87471918
70Longevity regulating pathway - mammal_Homo sapiens_hsa042110.87158239
71Renal cell carcinoma_Homo sapiens_hsa052110.86239793
72Melanoma_Homo sapiens_hsa052180.86237823
732-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.85417729
74Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.84945398
75ErbB signaling pathway_Homo sapiens_hsa040120.84509853
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.83727598
77Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.82888463
78Cyanoamino acid metabolism_Homo sapiens_hsa004600.82507096
79Thyroid cancer_Homo sapiens_hsa052160.82212204
80Gastric acid secretion_Homo sapiens_hsa049710.81927651
81Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.81912463
82Chemical carcinogenesis_Homo sapiens_hsa052040.80824511
83Cocaine addiction_Homo sapiens_hsa050300.80820234
84Pathways in cancer_Homo sapiens_hsa052000.80413558
85Steroid hormone biosynthesis_Homo sapiens_hsa001400.79346369
86Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.78778476
87Regulation of actin cytoskeleton_Homo sapiens_hsa048100.75728297
88Vitamin digestion and absorption_Homo sapiens_hsa049770.75368200
89Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.73766155
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.73711822
91Mineral absorption_Homo sapiens_hsa049780.73336631
92cGMP-PKG signaling pathway_Homo sapiens_hsa040220.73150110
93Renin secretion_Homo sapiens_hsa049240.73058893
94VEGF signaling pathway_Homo sapiens_hsa043700.71669127
95Prostate cancer_Homo sapiens_hsa052150.71564363
96Arginine and proline metabolism_Homo sapiens_hsa003300.71407260
97beta-Alanine metabolism_Homo sapiens_hsa004100.71247007
98Long-term depression_Homo sapiens_hsa047300.70170908
99Oxytocin signaling pathway_Homo sapiens_hsa049210.69343606
100Colorectal cancer_Homo sapiens_hsa052100.66056945
101Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.64485734
102Vascular smooth muscle contraction_Homo sapiens_hsa042700.64472797
103Aldosterone synthesis and secretion_Homo sapiens_hsa049250.64193495
104Salivary secretion_Homo sapiens_hsa049700.64134701
105Thyroid hormone synthesis_Homo sapiens_hsa049180.63636412
106Adipocytokine signaling pathway_Homo sapiens_hsa049200.62530411
107Insulin secretion_Homo sapiens_hsa049110.61658759
108Long-term potentiation_Homo sapiens_hsa047200.60738242
109Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60404392
110Butanoate metabolism_Homo sapiens_hsa006500.60319923
111Oocyte meiosis_Homo sapiens_hsa041140.59086838
112Taste transduction_Homo sapiens_hsa047420.58068879
113Dopaminergic synapse_Homo sapiens_hsa047280.57880018
114Chronic myeloid leukemia_Homo sapiens_hsa052200.57602650
115Tryptophan metabolism_Homo sapiens_hsa003800.57163032
116Pancreatic secretion_Homo sapiens_hsa049720.56964531
117Primary bile acid biosynthesis_Homo sapiens_hsa001200.55179041
118* Leukocyte transendothelial migration_Homo sapiens_hsa046700.54996935
119Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54981031
120Prion diseases_Homo sapiens_hsa050200.54784477
121Caffeine metabolism_Homo sapiens_hsa002320.54330685
122Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54268802
123Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.54158134
124PI3K-Akt signaling pathway_Homo sapiens_hsa041510.54026497
125FoxO signaling pathway_Homo sapiens_hsa040680.53209561
126Maturity onset diabetes of the young_Homo sapiens_hsa049500.52783794
127Linoleic acid metabolism_Homo sapiens_hsa005910.52470218
128Amphetamine addiction_Homo sapiens_hsa050310.52456194
129Propanoate metabolism_Homo sapiens_hsa006400.52201375
130Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.52073001
131AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.51883042
132Ovarian steroidogenesis_Homo sapiens_hsa049130.51740346
133Circadian entrainment_Homo sapiens_hsa047130.49555285
134Circadian rhythm_Homo sapiens_hsa047100.48731862
135Choline metabolism in cancer_Homo sapiens_hsa052310.48530359
136Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.48230537
137Glycerolipid metabolism_Homo sapiens_hsa005610.47551142
138Non-small cell lung cancer_Homo sapiens_hsa052230.47126845

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