MLLT10P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synapsis (GO:0007129)6.86740737
2piRNA metabolic process (GO:0034587)6.56569471
3inositol phosphate catabolic process (GO:0071545)5.58268457
4inositol phosphate dephosphorylation (GO:0046855)5.57911202
5phosphorylated carbohydrate dephosphorylation (GO:0046838)5.57911202
6DNA methylation involved in gamete generation (GO:0043046)5.50039187
7platelet dense granule organization (GO:0060155)4.51301284
8mitotic sister chromatid cohesion (GO:0007064)4.38612200
9dopamine transport (GO:0015872)4.26750791
10polyol catabolic process (GO:0046174)4.21919636
11cullin deneddylation (GO:0010388)4.17294471
12iron ion import (GO:0097286)4.13555075
13replication fork processing (GO:0031297)4.00440933
14chromosome organization involved in meiosis (GO:0070192)3.93996750
15DNA deamination (GO:0045006)3.90921144
16male meiosis (GO:0007140)3.78754053
17protein-chromophore linkage (GO:0018298)3.78362515
18male meiosis I (GO:0007141)3.76184876
19protein deneddylation (GO:0000338)3.74554220
20folic acid-containing compound biosynthetic process (GO:0009396)3.66517103
21protein K11-linked deubiquitination (GO:0035871)3.65643792
22lactate metabolic process (GO:0006089)3.62898929
23negative regulation of exocytosis (GO:0045920)3.59150360
24regulation of hexokinase activity (GO:1903299)3.54950820
25regulation of glucokinase activity (GO:0033131)3.54950820
26peptidyl-histidine modification (GO:0018202)3.47734671
27protein targeting to Golgi (GO:0000042)3.44827690
28maturation of 5.8S rRNA (GO:0000460)3.41423438
29DNA replication-dependent nucleosome organization (GO:0034723)3.40255934
30DNA replication-dependent nucleosome assembly (GO:0006335)3.40255934
31signal peptide processing (GO:0006465)3.39605270
32gonadal mesoderm development (GO:0007506)3.37300321
33cardiac left ventricle morphogenesis (GO:0003214)3.34242081
34establishment of protein localization to Golgi (GO:0072600)3.32396831
35microtubule nucleation (GO:0007020)3.29089987
36transcription from mitochondrial promoter (GO:0006390)3.29047222
37meiotic chromosome segregation (GO:0045132)3.28453130
38somatic diversification of immune receptors via somatic mutation (GO:0002566)3.28089904
39somatic hypermutation of immunoglobulin genes (GO:0016446)3.28089904
40proline transport (GO:0015824)3.26675532
41cellular ketone body metabolic process (GO:0046950)3.24009272
42retrograde transport, vesicle recycling within Golgi (GO:0000301)3.23082084
43pteridine-containing compound biosynthetic process (GO:0042559)3.22440765
44inositol metabolic process (GO:0006020)3.20659603
45regulation of meiosis I (GO:0060631)3.18908639
46retinol metabolic process (GO:0042572)3.17266911
47sister chromatid cohesion (GO:0007062)3.11447678
48transcytosis (GO:0045056)3.08855949
49regulation of mitotic spindle checkpoint (GO:1903504)3.08512050
50regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.08512050
51succinate metabolic process (GO:0006105)3.08143992
52water-soluble vitamin biosynthetic process (GO:0042364)3.07016291
53purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.06928024
543-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.06928024
55resolution of meiotic recombination intermediates (GO:0000712)3.05704142
56DNA double-strand break processing (GO:0000729)3.03296101
57positive regulation of meiosis (GO:0045836)3.01890450
58histone H4-K5 acetylation (GO:0043981)3.00421734
59histone H4-K8 acetylation (GO:0043982)3.00421734
60ribonucleoprotein complex disassembly (GO:0032988)2.99839954
61ncRNA 3-end processing (GO:0043628)2.97039030
62rhodopsin mediated signaling pathway (GO:0016056)2.95617624
63tachykinin receptor signaling pathway (GO:0007217)2.95610338
64ketone body metabolic process (GO:1902224)2.92625074
65DNA synthesis involved in DNA repair (GO:0000731)2.90937408
66energy homeostasis (GO:0097009)2.90770774
67intra-Golgi vesicle-mediated transport (GO:0006891)2.89535028
68mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.88829873
69positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.88829873
70phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.84942686
71gene silencing by RNA (GO:0031047)2.84394547
72regulation of protein glycosylation (GO:0060049)2.84098911
73meiotic nuclear division (GO:0007126)2.81447131
74mannosylation (GO:0097502)2.80882043
75reciprocal DNA recombination (GO:0035825)2.80570975
76reciprocal meiotic recombination (GO:0007131)2.80570975
77protein localization to Golgi apparatus (GO:0034067)2.79929309
78positive regulation of heat generation (GO:0031652)2.78833645
79response to misfolded protein (GO:0051788)2.78387727
80righting reflex (GO:0060013)2.77974316
81positive regulation of meiotic cell cycle (GO:0051446)2.77453037
82negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.73761497
83inositol phosphate-mediated signaling (GO:0048016)2.73518977
84positive regulation of respiratory burst (GO:0060267)2.71610041
85zinc ion homeostasis (GO:0055069)2.69343444
86behavioral response to nicotine (GO:0035095)2.69277278
87negative regulation of acute inflammatory response (GO:0002674)2.66319714
88misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.64777921
89protein-cofactor linkage (GO:0018065)2.64654497
90retinal cone cell development (GO:0046549)2.62678313
91insulin secretion (GO:0030073)2.61089995
92detection of calcium ion (GO:0005513)2.60564352
93protein K11-linked ubiquitination (GO:0070979)2.57743119
94meiotic cell cycle (GO:0051321)2.55744532
95heart process (GO:0003015)2.55109770
96heart contraction (GO:0060047)2.55109770
97negative regulation of mast cell activation (GO:0033004)2.53454584
98vitamin transmembrane transport (GO:0035461)2.52442527
99meiosis I (GO:0007127)2.51887565
100centriole assembly (GO:0098534)2.51673551

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.73507245
2VDR_22108803_ChIP-Seq_LS180_Human3.20947578
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.19770029
4POU3F2_20337985_ChIP-ChIP_501MEL_Human3.19304060
5IGF1R_20145208_ChIP-Seq_DFB_Human3.05209423
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.73444294
7FUS_26573619_Chip-Seq_HEK293_Human2.59633628
8NOTCH1_21737748_ChIP-Seq_TLL_Human2.37777050
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.20254011
10EZH2_22144423_ChIP-Seq_EOC_Human2.13140272
11PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.10652626
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.10143584
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.09918758
14ER_23166858_ChIP-Seq_MCF-7_Human2.05266489
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.01139903
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.93947384
17TP53_22573176_ChIP-Seq_HFKS_Human1.88397505
18ELK1_19687146_ChIP-ChIP_HELA_Human1.84265430
19PCGF2_27294783_Chip-Seq_ESCs_Mouse1.83731571
20VDR_23849224_ChIP-Seq_CD4+_Human1.83357436
21CTBP2_25329375_ChIP-Seq_LNCAP_Human1.83207860
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.71858022
23BCAT_22108803_ChIP-Seq_LS180_Human1.71317466
24SRF_21415370_ChIP-Seq_HL-1_Mouse1.63571641
25EST1_17652178_ChIP-ChIP_JURKAT_Human1.60691797
26GBX2_23144817_ChIP-Seq_PC3_Human1.60333902
27STAT3_23295773_ChIP-Seq_U87_Human1.59368383
28AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.58982328
29SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.57342545
30FOXA1_27270436_Chip-Seq_PROSTATE_Human1.56075904
31FOXA1_25329375_ChIP-Seq_VCAP_Human1.56075904
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.55883402
33EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.54070056
34HTT_18923047_ChIP-ChIP_STHdh_Human1.52682286
35P300_19829295_ChIP-Seq_ESCs_Human1.51754476
36PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.50103426
37NANOG_19829295_ChIP-Seq_ESCs_Human1.45659842
38SOX2_19829295_ChIP-Seq_ESCs_Human1.45659842
39MYC_18940864_ChIP-ChIP_HL60_Human1.43563678
40EWS_26573619_Chip-Seq_HEK293_Human1.42224459
41FOXP3_21729870_ChIP-Seq_TREG_Human1.41154134
42EZH2_27294783_Chip-Seq_NPCs_Mouse1.39686698
43TCF4_23295773_ChIP-Seq_U87_Human1.39271809
44SMAD4_21799915_ChIP-Seq_A2780_Human1.38684686
45MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.38515762
46AR_25329375_ChIP-Seq_VCAP_Human1.37448484
47EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.35504452
48FOXA1_21572438_ChIP-Seq_LNCaP_Human1.35166014
49PADI4_21655091_ChIP-ChIP_MCF-7_Human1.34592893
50SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33306505
51RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.33252616
52FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.30134250
53NFE2_27457419_Chip-Seq_LIVER_Mouse1.29909860
54PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.28026491
55BP1_19119308_ChIP-ChIP_Hs578T_Human1.26958913
56TAF15_26573619_Chip-Seq_HEK293_Human1.26717284
57PRDM14_20953172_ChIP-Seq_ESCs_Human1.26203568
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24497110
59UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23390540
60RUNX2_22187159_ChIP-Seq_PCA_Human1.22965475
61SUZ12_27294783_Chip-Seq_NPCs_Mouse1.22936365
62CDX2_22108803_ChIP-Seq_LS180_Human1.22816974
63GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21213521
64PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.21047108
65ETV2_25802403_ChIP-Seq_MESCs_Mouse1.19177387
66PCGF2_27294783_Chip-Seq_NPCs_Mouse1.19173556
67SMAD3_21741376_ChIP-Seq_EPCs_Human1.17891285
68PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.15792334
69TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.15766825
70AR_20517297_ChIP-Seq_VCAP_Human1.14974217
71OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14875047
72BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.14486368
73TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14206464
74TCF4_22108803_ChIP-Seq_LS180_Human1.13831137
75KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12568657
76ETS1_20019798_ChIP-Seq_JURKAT_Human1.08749745
77ERG_20517297_ChIP-Seq_VCAP_Human1.07520532
78CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.07086965
79FOXH1_21741376_ChIP-Seq_EPCs_Human1.06300605
80P53_22387025_ChIP-Seq_ESCs_Mouse1.05933273
81FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.05361261
82MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05088385
83GATA3_21878914_ChIP-Seq_MCF-7_Human1.04332606
84STAT3_18555785_Chip-Seq_ESCs_Mouse1.03897295
85NANOG_18555785_Chip-Seq_ESCs_Mouse1.03619279
86TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03113491
87CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02947037
88EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02914097
89CRX_20693478_ChIP-Seq_RETINA_Mouse1.02415736
90JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.02300091
91GATA3_26560356_Chip-Seq_TH1_Human1.01992155
92CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.01577179
93PHF8_20622853_ChIP-Seq_HELA_Human1.01510024
94NMYC_18555785_Chip-Seq_ESCs_Mouse1.00371296
95NCOR_22424771_ChIP-Seq_293T_Human0.99800772
96EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.99307097
97SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.97908557
98TAL1_26923725_Chip-Seq_HPCs_Mouse0.97793973
99MYC_19829295_ChIP-Seq_ESCs_Human0.97785669
100CMYC_18555785_Chip-Seq_ESCs_Mouse0.97588231

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation4.67169153
2MP0002638_abnormal_pupillary_reflex4.59539273
3MP0002822_catalepsy4.27225922
4MP0004147_increased_porphyrin_level4.23456183
5MP0005083_abnormal_biliary_tract4.10973233
6MP0008877_abnormal_DNA_methylation3.30705776
7MP0005379_endocrine/exocrine_gland_phen3.21307664
8MP0005084_abnormal_gallbladder_morpholo2.84620703
9MP0005085_abnormal_gallbladder_physiolo2.81563927
10MP0003195_calcinosis2.69490513
11MP0005365_abnormal_bile_salt2.55964542
12MP0010386_abnormal_urinary_bladder2.55204406
13MP0005075_abnormal_melanosome_morpholog2.26241583
14MP0008058_abnormal_DNA_repair2.12650608
15MP0002928_abnormal_bile_duct2.08667627
16MP0002160_abnormal_reproductive_system2.06715045
17MP0006072_abnormal_retinal_apoptosis1.98598029
18MP0001764_abnormal_homeostasis1.85318763
19MP0002163_abnormal_gland_morphology1.85202666
20MP0005253_abnormal_eye_physiology1.82619899
21MP0002837_dystrophic_cardiac_calcinosis1.78605669
22MP0005645_abnormal_hypothalamus_physiol1.75565524
23MP0002139_abnormal_hepatobiliary_system1.72664025
24MP0008775_abnormal_heart_ventricle1.69976831
25MP0005551_abnormal_eye_electrophysiolog1.69173859
26MP0000427_abnormal_hair_cycle1.67881811
27MP0008057_abnormal_DNA_replication1.64919407
28MP0008995_early_reproductive_senescence1.61158441
29MP0005332_abnormal_amino_acid1.58612810
30MP0002909_abnormal_adrenal_gland1.56702767
31MP0002876_abnormal_thyroid_physiology1.55761473
32MP0001501_abnormal_sleep_pattern1.50558136
33MP0003252_abnormal_bile_duct1.48546155
34MP0001986_abnormal_taste_sensitivity1.43724999
35MP0003786_premature_aging1.41450092
36MP0003943_abnormal_hepatobiliary_system1.38730637
37MP0003787_abnormal_imprinting1.36403840
38MP0005389_reproductive_system_phenotype1.33365225
39MP0002210_abnormal_sex_determination1.32466850
40MP0003868_abnormal_feces_composition1.30992182
41MP0001929_abnormal_gametogenesis1.23803194
42MP0009046_muscle_twitch1.22985159
43MP0004043_abnormal_pH_regulation1.22222540
44MP0000013_abnormal_adipose_tissue1.20385282
45MP0002272_abnormal_nervous_system1.12231259
46MP0001145_abnormal_male_reproductive1.10261127
47MP0008875_abnormal_xenobiotic_pharmacok1.06466701
48MP0005167_abnormal_blood-brain_barrier1.05810350
49MP0010678_abnormal_skin_adnexa1.04832480
50MP0010094_abnormal_chromosome_stability1.04540346
51MP0001835_abnormal_antigen_presentation1.03948956
52MP0003880_abnormal_central_pattern1.03318650
53MP0000653_abnormal_sex_gland1.02503869
54MP0009780_abnormal_chondrocyte_physiolo1.02368956
55MP0001502_abnormal_circadian_rhythm1.01828865
56MP0001905_abnormal_dopamine_level1.01362240
57MP0004145_abnormal_muscle_electrophysio1.01135114
58MP0000383_abnormal_hair_follicle0.97935873
59MP0008872_abnormal_physiological_respon0.96841505
60MP0009745_abnormal_behavioral_response0.95568867
61MP0000372_irregular_coat_pigmentation0.95050132
62MP0005220_abnormal_exocrine_pancreas0.95009896
63MP0003693_abnormal_embryo_hatching0.94959235
64MP0005535_abnormal_body_temperature0.94828366
65MP0001853_heart_inflammation0.91155867
66MP0005636_abnormal_mineral_homeostasis0.90402919
67MP0005310_abnormal_salivary_gland0.89658402
68MP0003698_abnormal_male_reproductive0.87625352
69MP0003718_maternal_effect0.86755172
70MP0000538_abnormal_urinary_bladder0.85230401
71MP0002693_abnormal_pancreas_physiology0.81792018
72MP0002735_abnormal_chemical_nociception0.80840293
73MP0001666_abnormal_nutrient_absorption0.80102234
74MP0005646_abnormal_pituitary_gland0.79011540
75MP0008873_increased_physiological_sensi0.76314055
76MP0003183_abnormal_peptide_metabolism0.74346078
77MP0010234_abnormal_vibrissa_follicle0.74097529
78MP0003123_paternal_imprinting0.74061728
79MP0002118_abnormal_lipid_homeostasis0.73744771
80MP0005448_abnormal_energy_balance0.73533644
81MP0003283_abnormal_digestive_organ0.73022520
82MP0002078_abnormal_glucose_homeostasis0.72650628
83MP0006082_CNS_inflammation0.70657459
84MP0002102_abnormal_ear_morphology0.70352074
85MP0004142_abnormal_muscle_tone0.70024809
86MP0001944_abnormal_pancreas_morphology0.67750430
87MP0005647_abnormal_sex_gland0.67593130
88MP0001765_abnormal_ion_homeostasis0.62861113
89MP0000230_abnormal_systemic_arterial0.61419308
90MP0002229_neurodegeneration0.60329899
91MP0002064_seizures0.59566478
92MP0003186_abnormal_redox_activity0.59168094
93MP0009333_abnormal_splenocyte_physiolog0.58397789
94MP0000015_abnormal_ear_pigmentation0.58106070
95MP0004924_abnormal_behavior0.58063293
96MP0005386_behavior/neurological_phenoty0.58063293
97MP0001119_abnormal_female_reproductive0.57259518
98MP0010329_abnormal_lipoprotein_level0.56581855
99MP0003953_abnormal_hormone_level0.55649179
100MP0005376_homeostasis/metabolism_phenot0.55478970

Predicted human phenotypes

RankGene SetZ-score
1Abnormal hair whorl (HP:0010721)4.91376498
2Azoospermia (HP:0000027)4.84377502
3Abnormality of the corticospinal tract (HP:0002492)4.12852064
4Methylmalonic acidemia (HP:0002912)3.78370423
5Abnormal spermatogenesis (HP:0008669)3.76601422
6Hypoglycemic coma (HP:0001325)3.75276578
7Abnormality of the renal cortex (HP:0011035)3.62991919
8Volvulus (HP:0002580)3.54457825
9Methylmalonic aciduria (HP:0012120)3.50367688
10Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.41381623
11Degeneration of the lateral corticospinal tracts (HP:0002314)3.41381623
12Ketoacidosis (HP:0001993)3.23981416
13Patchy hypopigmentation of hair (HP:0011365)3.22438454
14Hypoglycemic seizures (HP:0002173)3.21011748
15Short tibia (HP:0005736)3.17180622
16Aplasia/Hypoplasia of the tibia (HP:0005772)3.12226260
17White forelock (HP:0002211)3.11522755
18Testicular atrophy (HP:0000029)3.06250940
19Pancreatic cysts (HP:0001737)3.00072874
20Chronic hepatic failure (HP:0100626)2.91587365
21Hyperinsulinemic hypoglycemia (HP:0000825)2.90539998
22Nephronophthisis (HP:0000090)2.83946574
23Molar tooth sign on MRI (HP:0002419)2.78368857
24Abnormality of midbrain morphology (HP:0002418)2.78368857
25Hypothermia (HP:0002045)2.75282717
26Abnormality of vitamin B metabolism (HP:0004340)2.69771174
27Renal cortical cysts (HP:0000803)2.62502292
28Progressive inability to walk (HP:0002505)2.62206236
29Pancreatic fibrosis (HP:0100732)2.59609084
30Ketosis (HP:0001946)2.56326854
31Abnormality of the renal medulla (HP:0100957)2.45707017
32True hermaphroditism (HP:0010459)2.44504045
33Abnormality of the lower motor neuron (HP:0002366)2.39778507
34Abnormality of the vitamin B12 metabolism (HP:0004341)2.36754970
35Symptomatic seizures (HP:0011145)2.35199775
36Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.32624858
37Abnormality of alanine metabolism (HP:0010916)2.32624858
38Hyperalaninemia (HP:0003348)2.32624858
39Abnormal biliary tract physiology (HP:0012439)2.32548693
40Bile duct proliferation (HP:0001408)2.32548693
41Fibular hypoplasia (HP:0003038)2.27151190
42Amyotrophic lateral sclerosis (HP:0007354)2.26930466
43Gonadotropin excess (HP:0000837)2.25462192
44Tubular atrophy (HP:0000092)2.24857396
45Abolished electroretinogram (ERG) (HP:0000550)2.22417556
46Dicarboxylic aciduria (HP:0003215)2.19024576
47Abnormality of dicarboxylic acid metabolism (HP:0010995)2.19024576
48Pili torti (HP:0003777)2.17054916
49Progressive macrocephaly (HP:0004481)2.16343214
50Abnormal drinking behavior (HP:0030082)2.14933195
51Polydipsia (HP:0001959)2.14933195
52Abnormality of endocrine pancreas physiology (HP:0012093)2.12140244
53Abnormality of the pancreatic islet cells (HP:0006476)2.12140244
54Acute necrotizing encephalopathy (HP:0006965)2.09756465
55Cutaneous melanoma (HP:0012056)2.07877857
56Gaze-evoked nystagmus (HP:0000640)2.07438422
57Tachypnea (HP:0002789)2.06870168
58Type I transferrin isoform profile (HP:0003642)2.02935804
59Hypokinesia (HP:0002375)2.02488764
60Atrophy/Degeneration involving motor neurons (HP:0007373)2.02038918
61Attenuation of retinal blood vessels (HP:0007843)2.01726389
62Absent thumb (HP:0009777)2.01430215
63Unilateral renal agenesis (HP:0000122)2.01226179
64Metaphyseal dysplasia (HP:0100255)1.99535659
65Hepatic necrosis (HP:0002605)1.99037729
66Hand muscle atrophy (HP:0009130)1.98534643
67Hypoplastic iliac wings (HP:0002866)1.98507495
68Cystic liver disease (HP:0006706)1.97783965
69Type II lissencephaly (HP:0007260)1.97254793
70Upper motor neuron abnormality (HP:0002127)1.93786990
71Type I diabetes mellitus (HP:0100651)1.91817617
72Abnormality of vitamin metabolism (HP:0100508)1.91568800
73Impaired vibration sensation in the lower limbs (HP:0002166)1.89904300
74Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.87322424
75Abnormal protein N-linked glycosylation (HP:0012347)1.87322424
76Abnormal protein glycosylation (HP:0012346)1.87322424
77Abnormal glycosylation (HP:0012345)1.87322424
78Diminished movement (HP:0002374)1.85619636
79EEG with generalized epileptiform discharges (HP:0011198)1.84700142
80Downturned corners of mouth (HP:0002714)1.83978281
81Increased CSF lactate (HP:0002490)1.82714555
82Aplasia/Hypoplasia of the tongue (HP:0010295)1.82529572
83Hyperglycemia (HP:0003074)1.82510539
84Abnormal hair laboratory examination (HP:0003328)1.80892579
85Tongue fasciculations (HP:0001308)1.76462231
86Abnormality of homocysteine metabolism (HP:0010919)1.74983821
87Homocystinuria (HP:0002156)1.74983821
88Decreased activity of mitochondrial respiratory chain (HP:0008972)1.74260194
89Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.74260194
90Epileptiform EEG discharges (HP:0011182)1.74113295
91Neoplasm of the thyroid gland (HP:0100031)1.73850352
92Acute myeloid leukemia (HP:0004808)1.73653838
93Horizontal nystagmus (HP:0000666)1.73473607
94Hyperthyroidism (HP:0000836)1.72593370
95Acute encephalopathy (HP:0006846)1.71799120
96Abnormal mitochondria in muscle tissue (HP:0008316)1.70665285
97Inability to walk (HP:0002540)1.70363228
98Tetraplegia (HP:0002445)1.69806368
99Hypomagnesemia (HP:0002917)1.69786172
100Mitochondrial inheritance (HP:0001427)1.69062343

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K25.03576009
2FRK4.78305204
3TAOK34.64690676
4NME14.16520821
5BMPR23.27655819
6EIF2AK32.74536930
7STK392.60512754
8WNK42.35123940
9PINK11.94730233
10OXSR11.83601256
11PNCK1.79568531
12NUAK11.77895728
13ACVR1B1.77597066
14PHKG21.71408732
15PHKG11.71408732
16GRK51.69388941
17NTRK31.65327683
18BMPR1B1.62555899
19LIMK11.62471661
20PIK3CG1.59905231
21MST41.53334172
22GRK11.44980560
23ERBB31.33271014
24MAP3K21.26603732
25TRPM71.23826633
26TNK21.09160343
27RIPK41.08122126
28MAPK131.07334802
29PTK2B1.07244890
30MAPKAPK31.03321588
31CSNK1G31.00269569
32CSNK1G20.97883532
33ADRBK20.97383626
34FGFR20.94794530
35STK30.92976074
36SCYL20.89346250
37MAP3K90.89070632
38MAP2K20.88857035
39TNIK0.84625707
40CSNK1G10.82388011
41MKNK20.80834325
42RAF10.78991446
43WNK30.78891526
44PAK30.78627189
45IKBKB0.74938078
46BUB10.74737663
47MAP3K40.74108314
48TTK0.71173366
49ZAK0.69666801
50CCNB10.67526822
51WEE10.65590681
52WNK10.64910895
53MUSK0.62346275
54DAPK20.61000496
55EIF2AK10.60821341
56INSRR0.60539132
57EIF2AK20.59887884
58MAP3K70.58948895
59IKBKE0.57703950
60CAMK10.55221370
61PRKAA10.55160266
62TEC0.55070933
63ATR0.55070350
64MAP2K10.54129546
65PRKAA20.53592181
66FGFR30.53110275
67ATM0.51392776
68RPS6KA40.49609475
69TXK0.48807529
70FER0.47421001
71PIM10.45919775
72PASK0.45498176
73STK38L0.45424960
74PRKCE0.45208379
75NEK90.44815063
76IRAK20.44427274
77DAPK10.43299669
78GRK60.41719503
79FLT30.39835300
80PRKG10.37106041
81PLK30.36485545
82CSNK1D0.35681984
83STK40.34999634
84OBSCN0.34372889
85MAP2K60.33117966
86CHEK20.31989338
87CAMK2A0.31985124
88CSF1R0.31512398
89PRKCG0.30372619
90STK160.30011828
91MAP3K140.29584543
92CAMK40.29091344
93PLK10.29038304
94CDK10.27109056
95TGFBR10.27084429
96CSNK1A10.26833422
97PRKCB0.26803975
98CDK190.26117500
99MARK30.26082508
100RPS6KB10.25897901

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030604.39870927
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.78385642
3Butanoate metabolism_Homo sapiens_hsa006502.50740397
4Regulation of autophagy_Homo sapiens_hsa041402.49690124
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.32906888
6One carbon pool by folate_Homo sapiens_hsa006702.31684736
7Homologous recombination_Homo sapiens_hsa034402.26484732
8Selenocompound metabolism_Homo sapiens_hsa004502.12372286
9Insulin secretion_Homo sapiens_hsa049112.03025607
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.92198868
11Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.90976336
12Propanoate metabolism_Homo sapiens_hsa006401.89683239
13Linoleic acid metabolism_Homo sapiens_hsa005911.86663327
14RNA degradation_Homo sapiens_hsa030181.82126257
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.75553044
16RNA polymerase_Homo sapiens_hsa030201.64758017
17Fanconi anemia pathway_Homo sapiens_hsa034601.64230364
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.62237256
19Retinol metabolism_Homo sapiens_hsa008301.55749684
20Primary bile acid biosynthesis_Homo sapiens_hsa001201.51412543
21Non-homologous end-joining_Homo sapiens_hsa034501.46484682
22ABC transporters_Homo sapiens_hsa020101.44337159
23Nitrogen metabolism_Homo sapiens_hsa009101.37769227
24Oxidative phosphorylation_Homo sapiens_hsa001901.34704543
25Folate biosynthesis_Homo sapiens_hsa007901.33713046
26Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.32313576
27Basal transcription factors_Homo sapiens_hsa030221.29673565
28Phototransduction_Homo sapiens_hsa047441.27859013
29Fatty acid metabolism_Homo sapiens_hsa012121.26581076
30Ether lipid metabolism_Homo sapiens_hsa005651.24802204
31Fatty acid elongation_Homo sapiens_hsa000621.21687810
32Nucleotide excision repair_Homo sapiens_hsa034201.20413332
33Dorso-ventral axis formation_Homo sapiens_hsa043201.20090980
34Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.16858833
35Steroid biosynthesis_Homo sapiens_hsa001001.16749609
36Arachidonic acid metabolism_Homo sapiens_hsa005901.15761535
37Inositol phosphate metabolism_Homo sapiens_hsa005621.14082875
38Parkinsons disease_Homo sapiens_hsa050121.12290563
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.05077587
40Fatty acid biosynthesis_Homo sapiens_hsa000611.01429502
41Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.97569387
42Mismatch repair_Homo sapiens_hsa034300.93588475
43Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93067312
44Olfactory transduction_Homo sapiens_hsa047400.91217219
45RNA transport_Homo sapiens_hsa030130.89209233
46Type I diabetes mellitus_Homo sapiens_hsa049400.88346669
47Tryptophan metabolism_Homo sapiens_hsa003800.87886669
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87749746
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.87569064
50Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.87307667
51Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.86659762
52Amphetamine addiction_Homo sapiens_hsa050310.86007462
53Steroid hormone biosynthesis_Homo sapiens_hsa001400.85880159
54Circadian rhythm_Homo sapiens_hsa047100.81257464
55Salivary secretion_Homo sapiens_hsa049700.80918557
56Oocyte meiosis_Homo sapiens_hsa041140.80012223
57Morphine addiction_Homo sapiens_hsa050320.79915648
58Pancreatic secretion_Homo sapiens_hsa049720.79679839
59Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.79676069
60RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.78677956
61mTOR signaling pathway_Homo sapiens_hsa041500.78360626
62beta-Alanine metabolism_Homo sapiens_hsa004100.77423388
63Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.77201252
64Peroxisome_Homo sapiens_hsa041460.77175962
65Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75979233
66Pyrimidine metabolism_Homo sapiens_hsa002400.74327997
67Glycerophospholipid metabolism_Homo sapiens_hsa005640.74083492
68Metabolic pathways_Homo sapiens_hsa011000.73127507
69Fatty acid degradation_Homo sapiens_hsa000710.67458885
70Thyroid hormone synthesis_Homo sapiens_hsa049180.66836353
71Sulfur metabolism_Homo sapiens_hsa009200.65671228
72Serotonergic synapse_Homo sapiens_hsa047260.65127980
73Long-term depression_Homo sapiens_hsa047300.64969488
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64146231
75Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64028702
76Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.63634105
77Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.62527451
78Sphingolipid metabolism_Homo sapiens_hsa006000.60904723
79Purine metabolism_Homo sapiens_hsa002300.59860848
80Alzheimers disease_Homo sapiens_hsa050100.59653608
81Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.59202270
82Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.58956559
83Ovarian steroidogenesis_Homo sapiens_hsa049130.57215318
84Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.55116492
85Collecting duct acid secretion_Homo sapiens_hsa049660.54672642
86Renin secretion_Homo sapiens_hsa049240.53432432
87Type II diabetes mellitus_Homo sapiens_hsa049300.52522259
88Nicotine addiction_Homo sapiens_hsa050330.51621388
89Huntingtons disease_Homo sapiens_hsa050160.51478459
90NF-kappa B signaling pathway_Homo sapiens_hsa040640.51304450
91Fat digestion and absorption_Homo sapiens_hsa049750.51216982
92Fructose and mannose metabolism_Homo sapiens_hsa000510.46597541
93Glutamatergic synapse_Homo sapiens_hsa047240.46434889
94Base excision repair_Homo sapiens_hsa034100.43658746
95Circadian entrainment_Homo sapiens_hsa047130.42233636
96Taste transduction_Homo sapiens_hsa047420.41671053
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41497455
98Glycerolipid metabolism_Homo sapiens_hsa005610.41264463
99Mineral absorption_Homo sapiens_hsa049780.41204398
100GABAergic synapse_Homo sapiens_hsa047270.39939399

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