MLLT10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transcription factor and has been identified as a partner gene involved in several chromosomal rearrangements resulting in various leukemias. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)6.73473203
2cilium or flagellum-dependent cell motility (GO:0001539)5.58644479
3DNA unwinding involved in DNA replication (GO:0006268)5.43459653
4mitotic sister chromatid cohesion (GO:0007064)5.39473182
5male meiosis (GO:0007140)5.34458190
6nuclear pore complex assembly (GO:0051292)4.94428290
7mitotic chromosome condensation (GO:0007076)4.56901778
8DNA methylation involved in gamete generation (GO:0043046)4.55774131
9monoubiquitinated protein deubiquitination (GO:0035520)4.55482507
10meiotic cell cycle (GO:0051321)4.51938805
11nuclear pore organization (GO:0006999)4.47320021
12positive regulation of histone H3-K4 methylation (GO:0051571)4.45717974
13kinetochore organization (GO:0051383)4.37209095
14histone H3-K4 trimethylation (GO:0080182)4.25487092
15regulation of meiosis I (GO:0060631)4.23543408
16protein localization to chromosome, centromeric region (GO:0071459)4.20570475
17meiotic chromosome segregation (GO:0045132)4.18333031
18regulation of sister chromatid cohesion (GO:0007063)4.12215095
19synaptonemal complex assembly (GO:0007130)4.11597843
20gene silencing by RNA (GO:0031047)4.08804780
21synaptonemal complex organization (GO:0070193)4.07290888
22male meiosis I (GO:0007141)4.03314850
23kinetochore assembly (GO:0051382)3.92422803
24mitotic sister chromatid segregation (GO:0000070)3.90958955
25protein localization to kinetochore (GO:0034501)3.90954830
26sister chromatid cohesion (GO:0007062)3.90237085
27regulation of histone H3-K9 methylation (GO:0051570)3.89451981
28mitotic metaphase plate congression (GO:0007080)3.88531917
29attachment of spindle microtubules to kinetochore (GO:0008608)3.87812275
30axonemal dynein complex assembly (GO:0070286)3.83900498
31meiotic nuclear division (GO:0007126)3.81868636
32histone exchange (GO:0043486)3.81573479
33regulation of histone H3-K27 methylation (GO:0061085)3.77472616
34positive regulation of histone methylation (GO:0031062)3.77091145
35pore complex assembly (GO:0046931)3.74718379
36metaphase plate congression (GO:0051310)3.74122519
37negative regulation of histone methylation (GO:0031061)3.73007142
38DNA alkylation (GO:0006305)3.72190660
39DNA methylation (GO:0006306)3.72190660
40sister chromatid segregation (GO:0000819)3.71663614
41DNA replication-independent nucleosome assembly (GO:0006336)3.68273219
42DNA replication-independent nucleosome organization (GO:0034724)3.68273219
43chromatin remodeling at centromere (GO:0031055)3.66347107
44CENP-A containing nucleosome assembly (GO:0034080)3.64870732
45DNA topological change (GO:0006265)3.64589714
46regulation of centriole replication (GO:0046599)3.62662477
47positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.62555176
48positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.62555176
49positive regulation of mitotic sister chromatid separation (GO:1901970)3.62555176
50regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.61983271
51mitotic nuclear envelope disassembly (GO:0007077)3.61486116
52regulation of DNA endoreduplication (GO:0032875)3.58014902
53fusion of sperm to egg plasma membrane (GO:0007342)3.56310587
54regulation of histone H3-K4 methylation (GO:0051569)3.52377000
55chromosome organization involved in meiosis (GO:0070192)3.51862752
56regulation of centrosome duplication (GO:0010824)3.50487177
57regulation of RNA export from nucleus (GO:0046831)3.47948700
58peptidyl-lysine trimethylation (GO:0018023)3.47318663
59epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.46311417
60centriole replication (GO:0007099)3.44958675
61meiosis I (GO:0007127)3.44915604
62positive regulation of chromosome segregation (GO:0051984)3.44715501
63negative regulation of translation, ncRNA-mediated (GO:0040033)3.40024967
64regulation of translation, ncRNA-mediated (GO:0045974)3.40024967
65negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.40024967
66motile cilium assembly (GO:0044458)3.39126085
67chromatin assembly or disassembly (GO:0006333)3.38462911
68establishment of chromosome localization (GO:0051303)3.38284007
69multicellular organism reproduction (GO:0032504)3.33414586
70heterochromatin organization (GO:0070828)3.31310506
71membrane disassembly (GO:0030397)3.30744403
72nuclear envelope disassembly (GO:0051081)3.30744403
73otic vesicle formation (GO:0030916)3.28978060
74microtubule depolymerization (GO:0007019)3.28879676
75meiotic cell cycle process (GO:1903046)3.28078320
76regulation of spindle organization (GO:0090224)3.27962302
77protein localization to chromosome (GO:0034502)3.27823736
78single strand break repair (GO:0000012)3.25771474
79regulation of chromosome segregation (GO:0051983)3.25284077
80regulation of histone methylation (GO:0031060)3.24764393
81chromosome segregation (GO:0007059)3.23708967
82DNA strand elongation involved in DNA replication (GO:0006271)3.23152130
83binding of sperm to zona pellucida (GO:0007339)3.22969654
84DNA replication initiation (GO:0006270)3.22179396
85spermatid development (GO:0007286)3.21816085
86synapsis (GO:0007129)3.21599664
87histone H2A monoubiquitination (GO:0035518)3.21595443
88DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.20013568
89maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.19571996
90sperm-egg recognition (GO:0035036)3.19450174
91DNA packaging (GO:0006323)3.19078335
92pre-miRNA processing (GO:0031054)3.17164885
93chromosome condensation (GO:0030261)3.15744268
94female gamete generation (GO:0007292)3.15292661
95DNA replication-dependent nucleosome assembly (GO:0006335)3.14156578
96DNA replication-dependent nucleosome organization (GO:0034723)3.14156578
97DNA replication checkpoint (GO:0000076)3.14115160
98gene silencing (GO:0016458)3.13666252
99negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.13219349
100DNA damage response, signal transduction resulting in transcription (GO:0042772)3.11149531
101protein K6-linked ubiquitination (GO:0085020)3.10687392
102epithelial cilium movement (GO:0003351)3.09988955
103regulation of centrosome cycle (GO:0046605)3.07420271
104DNA strand elongation (GO:0022616)3.05024570
105ATP-dependent chromatin remodeling (GO:0043044)3.04096237
106regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.02242124
107translesion synthesis (GO:0019985)3.02238987
108DNA methylation or demethylation (GO:0044728)3.01407789
109replication fork processing (GO:0031297)3.00918929
110regulation of mitotic spindle organization (GO:0060236)3.00532839
111negative regulation of DNA repair (GO:0045738)2.99030886
112spindle checkpoint (GO:0031577)2.97375096
113regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.97247841
114histone H3-K9 methylation (GO:0051567)2.96310137
115interkinetic nuclear migration (GO:0022027)2.95206772
116regulation of mitotic metaphase/anaphase transition (GO:0030071)2.94803144
117histone H3-K4 methylation (GO:0051568)2.94618715
118hindbrain development (GO:0030902)2.93442510
119chromosome organization (GO:0051276)2.93110049
120centriole assembly (GO:0098534)2.92025186
121cytoplasmic mRNA processing body assembly (GO:0033962)2.90945967
122histone lysine methylation (GO:0034968)2.90102916
123cell-cell recognition (GO:0009988)2.89238251
124negative regulation of meiosis (GO:0045835)2.88478143
125double-strand break repair via homologous recombination (GO:0000724)2.87514914
126peptidyl-lysine methylation (GO:0018022)2.83779212
127recombinational repair (GO:0000725)2.82968389
128reciprocal meiotic recombination (GO:0007131)2.81928939
129reciprocal DNA recombination (GO:0035825)2.81928939
130resolution of meiotic recombination intermediates (GO:0000712)2.76042150
131histone mRNA catabolic process (GO:0071044)2.74447722
132non-recombinational repair (GO:0000726)2.74302441
133double-strand break repair via nonhomologous end joining (GO:0006303)2.74302441
134mRNA splice site selection (GO:0006376)2.73294856
135DNA synthesis involved in DNA repair (GO:0000731)2.72910760
136regulation of chromatin silencing (GO:0031935)2.71700917
137DNA ligation (GO:0006266)2.68649894
138chromatin assembly (GO:0031497)2.67962496
139mitotic G2/M transition checkpoint (GO:0044818)2.63686489
140histone H3-K9 modification (GO:0061647)2.63214198
141intra-S DNA damage checkpoint (GO:0031573)2.61687024
142histone H4-K16 acetylation (GO:0043984)2.60350523
143embryonic camera-type eye development (GO:0031076)2.59454145
144negative regulation of DNA-dependent DNA replication (GO:2000104)2.59041351
145microtubule anchoring (GO:0034453)2.58162347
146regulation of helicase activity (GO:0051095)2.57042929
147centrosome organization (GO:0051297)2.56695965
148regulation of DNA methylation (GO:0044030)2.56670811
149microtubule organizing center organization (GO:0031023)2.55497701
150regulation of nuclear cell cycle DNA replication (GO:0033262)2.55385811
151negative regulation of fibroblast apoptotic process (GO:2000270)2.54260277
152regulation of timing of cell differentiation (GO:0048505)2.54094606
153regulation of development, heterochronic (GO:0040034)2.49177679
154DNA geometric change (GO:0032392)2.48749947
155acrosome reaction (GO:0007340)2.47717056
156histone methylation (GO:0016571)2.46849148
157somite development (GO:0061053)2.45301581
158DNA duplex unwinding (GO:0032508)2.43279718
159negative regulation of RNA splicing (GO:0033119)2.43232742
160alternative mRNA splicing, via spliceosome (GO:0000380)2.40383123
161regulation of mitotic sister chromatid segregation (GO:0033047)2.40182404
162regulation of sister chromatid segregation (GO:0033045)2.40182404

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.63137738
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.92040809
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.55785223
4E2F4_17652178_ChIP-ChIP_JURKAT_Human4.41367185
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.04653033
6SALL1_21062744_ChIP-ChIP_HESCs_Human3.35851571
7KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.91917707
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.89343346
9AR_21909140_ChIP-Seq_LNCAP_Human2.70230228
10E2F1_21310950_ChIP-Seq_MCF-7_Human2.44322815
11RBPJ_22232070_ChIP-Seq_NCS_Mouse2.43752466
12BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.34976369
13TP63_19390658_ChIP-ChIP_HaCaT_Human2.33958728
14ZNF274_21170338_ChIP-Seq_K562_Hela2.19314920
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.12357029
16VDR_22108803_ChIP-Seq_LS180_Human2.00867240
17IGF1R_20145208_ChIP-Seq_DFB_Human1.96549000
18* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.79956593
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.79749953
20* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.78677846
21MYC_18555785_ChIP-Seq_MESCs_Mouse1.78253682
22ZFP57_27257070_Chip-Seq_ESCs_Mouse1.73850658
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.71344529
24* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.69910496
25* P300_19829295_ChIP-Seq_ESCs_Human1.64392979
26TAF15_26573619_Chip-Seq_HEK293_Human1.61166785
27GBX2_23144817_ChIP-Seq_PC3_Human1.54243570
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.52718632
29AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.52406325
30YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.50860861
31PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49893354
32CIITA_25753668_ChIP-Seq_RAJI_Human1.48087584
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.47047594
34GATA1_26923725_Chip-Seq_HPCs_Mouse1.45668877
35EST1_17652178_ChIP-ChIP_JURKAT_Human1.43920239
36STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.41986064
37* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.39119736
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.38994360
39* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.38795092
40STAT3_23295773_ChIP-Seq_U87_Human1.37982384
41FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.37400959
42PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.35668152
43CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.35167179
44NELFA_20434984_ChIP-Seq_ESCs_Mouse1.34726466
45MYC_22102868_ChIP-Seq_BL_Human1.34395528
46KDM5A_27292631_Chip-Seq_BREAST_Human1.33572972
47HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.33025180
48ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.32040900
49SMAD4_21799915_ChIP-Seq_A2780_Human1.31662907
50* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.29487013
51ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.28686983
52VDR_23849224_ChIP-Seq_CD4+_Human1.28504808
53FUS_26573619_Chip-Seq_HEK293_Human1.28489710
54TCF4_23295773_ChIP-Seq_U87_Human1.27812031
55FOXP3_21729870_ChIP-Seq_TREG_Human1.27504049
56PCGF2_27294783_Chip-Seq_NPCs_Mouse1.26942156
57EWS_26573619_Chip-Seq_HEK293_Human1.25615444
58PIAS1_25552417_ChIP-Seq_VCAP_Human1.25526028
59FLI1_27457419_Chip-Seq_LIVER_Mouse1.25206624
60CBP_20019798_ChIP-Seq_JUKART_Human1.24696804
61IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.24696804
62WT1_19549856_ChIP-ChIP_CCG9911_Human1.21325665
63UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21178929
64KAP1_22055183_ChIP-Seq_ESCs_Mouse1.19741300
65DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.19576704
66EZH2_22144423_ChIP-Seq_EOC_Human1.18529339
67ER_23166858_ChIP-Seq_MCF-7_Human1.17437872
68EZH2_27294783_Chip-Seq_NPCs_Mouse1.16307628
69* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15342188
70EGR1_19374776_ChIP-ChIP_THP-1_Human1.13662938
71PKCTHETA_26484144_Chip-Seq_BREAST_Human1.13392282
72* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13128779
73HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.12039576
74* SMAD3_21741376_ChIP-Seq_EPCs_Human1.11757682
75* NANOG_18555785_Chip-Seq_ESCs_Mouse1.10630821
76MYC_18940864_ChIP-ChIP_HL60_Human1.09535023
77TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08564442
78PADI4_21655091_ChIP-ChIP_MCF-7_Human1.07533792
79FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.07356400
80TBX3_20139965_ChIP-Seq_ESCs_Mouse1.06923612
81RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.06728790
82TBX3_20139965_ChIP-Seq_MESCs_Mouse1.05865496
83KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.05791466
84STAT6_21828071_ChIP-Seq_BEAS2B_Human1.05352357
85* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05131528
86CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.03665130
87RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03447948
88AR_21572438_ChIP-Seq_LNCaP_Human1.03363080
89* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03077235
90RNF2_27304074_Chip-Seq_NSC_Mouse1.03020213
91SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.02745239
92NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02709058
93SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.01938281
94* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01353105
95TCF4_22108803_ChIP-Seq_LS180_Human1.00979703
96NANOG_21062744_ChIP-ChIP_HESCs_Human1.00478346
97* E2F1_18555785_Chip-Seq_ESCs_Mouse1.00456403
98SOX9_26525672_Chip-Seq_HEART_Mouse1.00288364
99STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.99100952
100* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.98969910
101RUNX2_22187159_ChIP-Seq_PCA_Human0.98399868
102* SOX2_16153702_ChIP-ChIP_HESCs_Human0.98032195
103POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.97400547
104SUZ12_27294783_Chip-Seq_NPCs_Mouse0.96860700
105* MYC_18358816_ChIP-ChIP_MESCs_Mouse0.96368813
106GABP_19822575_ChIP-Seq_HepG2_Human0.96142938
107PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.96062888
108NANOG_18555785_ChIP-Seq_MESCs_Mouse0.95008635
109FLI1_21867929_ChIP-Seq_TH2_Mouse0.94998809
110* MYB_26560356_Chip-Seq_TH1_Human0.94940783
111* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.93784684
112* NANOG_16153702_ChIP-ChIP_HESCs_Human0.92913467
113FOXM1_26456572_ChIP-Seq_MCF-7_Human0.92784458
114MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.92699360
115SCL_19346495_ChIP-Seq_HPC-7_Human0.92092644
116HOXB4_20404135_ChIP-ChIP_EML_Mouse0.91871561
117RUNX1_26923725_Chip-Seq_HPCs_Mouse0.91583597
118* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.91396318
119TCF4_18268006_ChIP-ChIP_LS174T_Human0.91129755
120NOTCH1_21737748_ChIP-Seq_TLL_Human0.91126962
121PCGF2_27294783_Chip-Seq_ESCs_Mouse0.90794886
122* KLF5_20875108_ChIP-Seq_MESCs_Mouse0.90703684
123* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.88168782
124BCAT_22108803_ChIP-Seq_LS180_Human0.87882755
125AR_25329375_ChIP-Seq_VCAP_Human0.87418975
126XRN2_22483619_ChIP-Seq_HELA_Human0.86093611
127SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.84332938
128ELK1_19687146_ChIP-ChIP_HELA_Human0.83477977
129* TTF2_22483619_ChIP-Seq_HELA_Human0.83314325
130FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.82730683
131* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.82442365
132* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.80215214
133MYB_26560356_Chip-Seq_TH2_Human0.80044559
134POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.79325819
135TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79325819
136CREB1_15753290_ChIP-ChIP_HEK293T_Human0.76877505
137KLF4_18555785_ChIP-Seq_MESCs_Mouse0.75921819
138SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.75269427
139* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.74812601
140CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.74808597
141POU3F2_20337985_ChIP-ChIP_501MEL_Human0.74727335
142* TCF7_22412390_ChIP-Seq_EML_Mouse0.74009429
143SOX2_18555785_ChIP-Seq_MESCs_Mouse0.74007124
144NFE2_27457419_Chip-Seq_LIVER_Mouse0.69754593
145CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.68701093
146SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.68582704
147ETS1_22383799_ChIP-Seq_G1ME_Mouse0.68482486
148IRF1_19129219_ChIP-ChIP_H3396_Human0.67971200
149ETS1_20019798_ChIP-Seq_JURKAT_Human0.67947830
150ZFX_18555785_ChIP-Seq_MESCs_Mouse0.67149471
151DCP1A_22483619_ChIP-Seq_HELA_Human0.67039630
152GABP_17652178_ChIP-ChIP_JURKAT_Human0.66950020
153FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.66531137
154MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.65306356
155ERG_20887958_ChIP-Seq_HPC-7_Mouse0.65114662
156SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.64679983
157TCF3_18692474_ChIP-Seq_MESCs_Mouse0.64365527
158* TBL1_22424771_ChIP-Seq_293T_Human0.63769315
159GATA3_26560356_Chip-Seq_TH1_Human0.62442050

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.88304089
2MP0008877_abnormal_DNA_methylation4.67372697
3MP0010094_abnormal_chromosome_stability4.33474292
4MP0003693_abnormal_embryo_hatching3.62347565
5MP0003111_abnormal_nucleus_morphology3.54415538
6MP0003077_abnormal_cell_cycle3.34845272
7MP0005410_abnormal_fertilization3.06819541
8MP0008058_abnormal_DNA_repair2.84785532
9MP0001929_abnormal_gametogenesis2.77160455
10MP0008007_abnormal_cellular_replicative2.74560192
11MP0004957_abnormal_blastocyst_morpholog2.68431788
12MP0003787_abnormal_imprinting2.64654268
13MP0002210_abnormal_sex_determination2.47144445
14MP0003121_genomic_imprinting2.16747610
15MP0002396_abnormal_hematopoietic_system2.09590057
16MP0002653_abnormal_ependyma_morphology2.08248343
17MP0003698_abnormal_male_reproductive2.06442762
18MP0000653_abnormal_sex_gland2.03509355
19MP0001145_abnormal_male_reproductive1.99304243
20MP0004808_abnormal_hematopoietic_stem1.90916148
21MP0002102_abnormal_ear_morphology1.89263683
22MP0003718_maternal_effect1.88322276
23MP0003123_paternal_imprinting1.78428836
24MP0000350_abnormal_cell_proliferation1.74848874
25MP0000569_abnormal_digit_pigmentation1.72675902
26MP0010307_abnormal_tumor_latency1.68322369
27MP0001730_embryonic_growth_arrest1.66667411
28MP0006292_abnormal_olfactory_placode1.66620205
29MP0002233_abnormal_nose_morphology1.64570686
30MP0003890_abnormal_embryonic-extraembry1.63086547
31MP0003122_maternal_imprinting1.61775284
32MP0000631_abnormal_neuroendocrine_gland1.57747007
33MP0008789_abnormal_olfactory_epithelium1.55542378
34MP0008932_abnormal_embryonic_tissue1.54351031
35MP0006072_abnormal_retinal_apoptosis1.52668322
36MP0001672_abnormal_embryogenesis/_devel1.51832184
37MP0005380_embryogenesis_phenotype1.51832184
38MP0001119_abnormal_female_reproductive1.50516178
39MP0005394_taste/olfaction_phenotype1.49386474
40MP0005499_abnormal_olfactory_system1.49386474
41MP0001697_abnormal_embryo_size1.47288607
42MP0002084_abnormal_developmental_patter1.47194553
43MP0003786_premature_aging1.46167919
44MP0004264_abnormal_extraembryonic_tissu1.45877043
45MP0002161_abnormal_fertility/fecundity1.45283542
46MP0001545_abnormal_hematopoietic_system1.44649778
47MP0005397_hematopoietic_system_phenotyp1.44649778
48MP0003136_yellow_coat_color1.44346333
49MP0002085_abnormal_embryonic_tissue1.40707447
50MP0003763_abnormal_thymus_physiology1.37944928
51MP0003984_embryonic_growth_retardation1.32225586
52MP0002088_abnormal_embryonic_growth/wei1.29410489
53MP0002086_abnormal_extraembryonic_tissu1.27424292
54MP0008995_early_reproductive_senescence1.25443440
55MP0003699_abnormal_female_reproductive1.23683190
56MP0003119_abnormal_digestive_system1.20561887
57MP0005174_abnormal_tail_pigmentation1.20090745
58MP0000490_abnormal_crypts_of1.17904281
59MP0005076_abnormal_cell_differentiation1.14739511
60MP0003937_abnormal_limbs/digits/tail_de1.13786417
61MP0000313_abnormal_cell_death1.13107179
62MP0002019_abnormal_tumor_incidence1.10591533
63MP0002009_preneoplasia1.09403907
64MP0000703_abnormal_thymus_morphology1.08611858
65MP0004133_heterotaxia1.08310233
66MP0002080_prenatal_lethality1.06550437
67MP0003567_abnormal_fetal_cardiomyocyte1.06324630
68MP0001293_anophthalmia1.05939529
69MP0005220_abnormal_exocrine_pancreas1.05771873
70MP0004197_abnormal_fetal_growth/weight/1.05737819
71MP0002697_abnormal_eye_size1.04335941
72MP0009278_abnormal_bone_marrow1.01368158
73MP0010352_gastrointestinal_tract_polyps1.00339102
74MP0003942_abnormal_urinary_system0.99863879
75MP0003938_abnormal_ear_development0.99442954
76MP0001915_intracranial_hemorrhage0.98736670
77MP0000778_abnormal_nervous_system0.97743931
78MP0004215_abnormal_myocardial_fiber0.96484652
79MP0002163_abnormal_gland_morphology0.96017129
80MP0000383_abnormal_hair_follicle0.95189350
81MP0000647_abnormal_sebaceous_gland0.94110308
82MP0002398_abnormal_bone_marrow0.93676475
83MP0005551_abnormal_eye_electrophysiolog0.93330947
84MP0000372_irregular_coat_pigmentation0.91637839
85MP0000432_abnormal_head_morphology0.90431351
86MP0005391_vision/eye_phenotype0.90143010
87MP0002249_abnormal_larynx_morphology0.90113980
88MP0005253_abnormal_eye_physiology0.89700241
89MP0009697_abnormal_copulation0.86100426
90MP0003935_abnormal_craniofacial_develop0.84841729
91MP0002109_abnormal_limb_morphology0.84462988
92MP0003385_abnormal_body_wall0.80770619
93MP0009703_decreased_birth_body0.80516345
94MP0003943_abnormal_hepatobiliary_system0.78600456
95MP0001188_hyperpigmentation0.77050714
96MP0005187_abnormal_penis_morphology0.76841103
97MP0002160_abnormal_reproductive_system0.76555733
98MP0005075_abnormal_melanosome_morpholog0.76381038
99MP0009672_abnormal_birth_weight0.75883725
100MP0005379_endocrine/exocrine_gland_phen0.74931255
101MP0006276_abnormal_autonomic_nervous0.74530738
102MP0002092_abnormal_eye_morphology0.72812608
103MP0005395_other_phenotype0.72401420
104MP0000427_abnormal_hair_cycle0.72232878
105MP0000689_abnormal_spleen_morphology0.72058681
106MP0003115_abnormal_respiratory_system0.71771682
107MP0002722_abnormal_immune_system0.71730130
108MP0009250_abnormal_appendicular_skeleto0.71704086
109MP0002111_abnormal_tail_morphology0.71517818
110MP0005645_abnormal_hypothalamus_physiol0.71424194
111MP0003646_muscle_fatigue0.71058037
112MP0010030_abnormal_orbit_morphology0.70678518
113MP0006035_abnormal_mitochondrial_morpho0.70287276
114MP0002925_abnormal_cardiovascular_devel0.70086019
115MP0003195_calcinosis0.69834893
116MP0002095_abnormal_skin_pigmentation0.69823569
117MP0005451_abnormal_body_composition0.69272454
118MP0005646_abnormal_pituitary_gland0.69120207
119MP0002127_abnormal_cardiovascular_syste0.68659436
120MP0002938_white_spotting0.67595820
121MP0003315_abnormal_perineum_morphology0.64893467
122MP0001286_abnormal_eye_development0.64882988
123MP0002006_tumorigenesis0.63541509
124MP0000566_synostosis0.63048903
125MP0002116_abnormal_craniofacial_bone0.62922645
126MP0005389_reproductive_system_phenotype0.62875276
127MP0005408_hypopigmentation0.62032824
128MP0003755_abnormal_palate_morphology0.61740582
129MP0003950_abnormal_plasma_membrane0.61228182
130MP0003861_abnormal_nervous_system0.60858850
131MP0005647_abnormal_sex_gland0.60101297
132MP0010678_abnormal_skin_adnexa0.58200437
133MP0000428_abnormal_craniofacial_morphol0.57923910
134MP0010368_abnormal_lymphatic_system0.56799882
135MP0005621_abnormal_cell_physiology0.56699523
136MP0005310_abnormal_salivary_gland0.56432838

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.81396662
2Chromsome breakage (HP:0040012)4.53081355
3Volvulus (HP:0002580)4.22934263
4Chromosomal breakage induced by crosslinking agents (HP:0003221)4.18150640
5Absent/shortened dynein arms (HP:0200106)4.01253907
6Dynein arm defect of respiratory motile cilia (HP:0012255)4.01253907
7Abnormality of the fingertips (HP:0001211)3.80909384
8Abnormal respiratory motile cilium physiology (HP:0012261)3.79896711
9Supernumerary spleens (HP:0009799)3.37808229
10Rhinitis (HP:0012384)3.33198083
11Ectopic kidney (HP:0000086)3.31099044
12Abnormality of chromosome stability (HP:0003220)3.25976690
13Nephronophthisis (HP:0000090)3.12466324
14Chronic bronchitis (HP:0004469)3.09270394
15Birth length less than 3rd percentile (HP:0003561)2.98480607
16Abnormal respiratory epithelium morphology (HP:0012253)2.96091482
17Abnormal respiratory motile cilium morphology (HP:0005938)2.96091482
18Papillary thyroid carcinoma (HP:0002895)2.95878692
19Nephroblastoma (Wilms tumor) (HP:0002667)2.89476604
20Aplasia/Hypoplasia of the uvula (HP:0010293)2.88375669
21Abnormality of cochlea (HP:0000375)2.88253646
22Diastasis recti (HP:0001540)2.85040728
23Meckel diverticulum (HP:0002245)2.81409440
24Abnormality of the preputium (HP:0100587)2.79273081
25Impulsivity (HP:0100710)2.79070446
26Abnormal ciliary motility (HP:0012262)2.75912862
27Abnormality of the ileum (HP:0001549)2.72109803
28Myelodysplasia (HP:0002863)2.72100193
29Hepatoblastoma (HP:0002884)2.70846960
30Embryonal renal neoplasm (HP:0011794)2.67919224
31Infertility (HP:0000789)2.64498103
32Abnormality of the renal medulla (HP:0100957)2.59686834
33Male infertility (HP:0003251)2.55764197
34Sloping forehead (HP:0000340)2.55587215
35Bronchiectasis (HP:0002110)2.54220836
36Hypoplastic iliac wings (HP:0002866)2.50263575
37Medulloblastoma (HP:0002885)2.46952073
38* Acute myeloid leukemia (HP:0004808)2.41383272
39Patellar aplasia (HP:0006443)2.41175350
40Chin dimple (HP:0010751)2.38996247
41Abnormality of midbrain morphology (HP:0002418)2.38582550
42Molar tooth sign on MRI (HP:0002419)2.38582550
43Small intestinal stenosis (HP:0012848)2.34902492
44Duodenal stenosis (HP:0100867)2.34902492
45Prominent nose (HP:0000448)2.31637536
46Abnormality of the carotid arteries (HP:0005344)2.30980266
47Clubbing of toes (HP:0100760)2.26176859
48Morphological abnormality of the inner ear (HP:0011390)2.23542025
49Long eyelashes (HP:0000527)2.22440240
50Increased nuchal translucency (HP:0010880)2.21897868
51Neoplasm of the adrenal cortex (HP:0100641)2.21302869
5211 pairs of ribs (HP:0000878)2.20267956
53Lip pit (HP:0100267)2.19923087
54Neoplasm of the oral cavity (HP:0100649)2.17439474
55Facial hemangioma (HP:0000329)2.16797755
56Septo-optic dysplasia (HP:0100842)2.15531098
57Aplasia/Hypoplasia of the patella (HP:0006498)2.13787865
58Abnormality of the septum pellucidum (HP:0007375)2.12654179
59Shawl scrotum (HP:0000049)2.12552088
60Selective tooth agenesis (HP:0001592)2.11511966
61Pancreatic fibrosis (HP:0100732)2.11317338
62Intestinal atresia (HP:0011100)2.07886229
63Optic nerve hypoplasia (HP:0000609)2.07806435
64Deep palmar crease (HP:0006191)2.05139904
65Nasal polyposis (HP:0100582)2.04527730
66Sandal gap (HP:0001852)2.04356441
67Absent septum pellucidum (HP:0001331)2.03847139
68Bronchitis (HP:0012387)2.03491889
69Aplasia/Hypoplasia of the sternum (HP:0006714)2.01685229
70Aqueductal stenosis (HP:0002410)1.99250564
71Tubulointerstitial nephritis (HP:0001970)1.99014803
72Partial agenesis of the corpus callosum (HP:0001338)1.97224914
73Abnormality of the labia minora (HP:0012880)1.95532607
74Abnormal spermatogenesis (HP:0008669)1.93745768
75Sparse lateral eyebrow (HP:0005338)1.93417055
76Vertebral arch anomaly (HP:0008438)1.93334187
77Heterotopia (HP:0002282)1.92625200
78Abnormal lung lobation (HP:0002101)1.91676585
79Acute lymphatic leukemia (HP:0006721)1.91603794
80Abnormality of the duodenum (HP:0002246)1.91248742
81Obsessive-compulsive behavior (HP:0000722)1.90683102
82Drooling (HP:0002307)1.90660476
83Aplastic anemia (HP:0001915)1.90596039
84Abnormality of the anterior horn cell (HP:0006802)1.88741938
85Degeneration of anterior horn cells (HP:0002398)1.88741938
86Abnormal hair whorl (HP:0010721)1.87582144
87Pancreatic cysts (HP:0001737)1.85902953
88Abnormal number of incisors (HP:0011064)1.85524552
89Neoplasm of striated muscle (HP:0009728)1.85441052
90Thyroid carcinoma (HP:0002890)1.85277247
91Supernumerary ribs (HP:0005815)1.84758270
92Supernumerary bones of the axial skeleton (HP:0009144)1.84648197
93Postaxial foot polydactyly (HP:0001830)1.84463304
94Abnormality of DNA repair (HP:0003254)1.83258487
95Oligodactyly (hands) (HP:0001180)1.81595360
96Truncal obesity (HP:0001956)1.81524698
97Missing ribs (HP:0000921)1.81201873
98Deep philtrum (HP:0002002)1.80348527
99Growth hormone deficiency (HP:0000824)1.79295894
100Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.79083419
101Abnormality of homocysteine metabolism (HP:0010919)1.78819185
102Homocystinuria (HP:0002156)1.78819185
103Fibular hypoplasia (HP:0003038)1.78728714
104Anal stenosis (HP:0002025)1.77799375
105Absent frontal sinuses (HP:0002688)1.77794998
106High pitched voice (HP:0001620)1.77361191
107Short 4th metacarpal (HP:0010044)1.77256033
108Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.77256033
109Colon cancer (HP:0003003)1.76751400
110Embryonal neoplasm (HP:0002898)1.76367993
111Long clavicles (HP:0000890)1.76329742
112Short thumb (HP:0009778)1.75611381
113True hermaphroditism (HP:0010459)1.75454584
114Duplicated collecting system (HP:0000081)1.75155754
115Aplasia/Hypoplasia of the earlobes (HP:0009906)1.74812230
116Breast hypoplasia (HP:0003187)1.74642066
117Oligodactyly (HP:0012165)1.74581457
118Macroorchidism (HP:0000053)1.72718962
119Abnormality of the renal cortex (HP:0011035)1.71644074
120Abnormality of the ischium (HP:0003174)1.71531941
121Midline defect of the nose (HP:0004122)1.71394157
122Bone marrow hypocellularity (HP:0005528)1.70896760
123Overlapping toe (HP:0001845)1.70454771
124Abnormality of chromosome segregation (HP:0002916)1.70411675
125Triphalangeal thumb (HP:0001199)1.70352202
126Hypoplastic ischia (HP:0003175)1.68657856
127Abnormality of the incisor (HP:0000676)1.67960448
128Broad thumb (HP:0011304)1.67753543
129Abnormality of the renal collecting system (HP:0004742)1.67219850
130Renal cortical cysts (HP:0000803)1.66327696
131Hypoplasia of the capital femoral epiphysis (HP:0003090)1.66067490
132Rhabdomyosarcoma (HP:0002859)1.66031037
133Cafe-au-lait spot (HP:0000957)1.65002508
134Excessive salivation (HP:0003781)1.64947777
135Hypochromic microcytic anemia (HP:0004840)1.64622502
136Capillary hemangiomas (HP:0005306)1.63574576
137Abnormality of the nasal septum (HP:0000419)1.63568162
138Blepharitis (HP:0000498)1.63263404
139Sex reversal (HP:0012245)1.63119599
140Abnormal sex determination (HP:0012244)1.63119599
141Medial flaring of the eyebrow (HP:0010747)1.62956530
142Absent radius (HP:0003974)1.62667079
143Abnormality of the nasal mucosa (HP:0000433)1.62428513
144Hyperglycinuria (HP:0003108)1.62014676
145Abnormal biliary tract physiology (HP:0012439)1.61694710
146Bile duct proliferation (HP:0001408)1.61694710
147Hypoplastic labia majora (HP:0000059)1.61674586
148Cystic liver disease (HP:0006706)1.61598088
149Highly arched eyebrow (HP:0002553)1.60974377
150Facial cleft (HP:0002006)1.60234889

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.06397370
2LATS13.61838490
3CDK123.61047142
4NEK23.37087177
5TTK3.10325558
6PLK43.05171997
7FRK2.83858495
8TNIK2.82046281
9STK32.46505125
10TAF12.46159866
11PDK32.45450576
12PDK42.45450576
13MAP3K62.32256588
14EEF2K2.16657814
15CHEK22.11319685
16STK38L2.10067059
17ACVR1B2.07177431
18MAP3K91.96831419
19WEE11.92867871
20SRPK11.92075249
21ATR1.83589814
22FGFR21.81628358
23AKT31.81006378
24NUAK11.80323643
25CDK91.70320997
26TAOK31.67773677
27STK101.65071153
28PLK11.62849680
29CDK71.53845414
30CHEK11.50525515
31CDK81.48996651
32MELK1.48019766
33ATM1.44431387
34BRD41.44256472
35NEK11.41573925
36TGFBR11.40068336
37PNCK1.33449921
38AURKB1.33164714
39CDK41.30879906
40BRSK21.29783717
41CASK1.29471749
42WNK41.26099046
43PDK21.20541972
44WNK31.16705887
45MKNK11.12598086
46BMPR1B1.11639599
47DYRK31.11405246
48RPS6KB21.06452104
49PRKD31.03411440
50TAOK11.02863654
51BUB11.02555434
52EIF2AK11.00864756
53STK391.00841188
54PBK0.99550086
55EIF2AK30.99128818
56MKNK20.97924759
57STK40.96940328
58MAP3K130.95664628
59LATS20.95360956
60MUSK0.95353906
61FLT30.94191667
62CDK30.93438811
63PLK30.92093205
64MAPK130.91953779
65CDK20.89658383
66RAF10.89327139
67CDK60.88980291
68ICK0.88174315
69DMPK0.84751599
70PASK0.80296008
71STK240.79470997
72CDK10.77725380
73VRK10.77605764
74MAP3K80.77173656
75BRAF0.76662006
76ERBB40.76577000
77FGFR10.75774011
78MTOR0.75545718
79MARK10.72591349
80PINK10.72035138
81MAP3K100.68695540
82PIM10.68412097
83TYRO30.67061484
84CSNK1E0.64904261
85CAMK1G0.64532943
86MARK30.64379162
87PLK20.62858378
88MAP4K10.61934317
89RPS6KA40.60483418
90JAK30.59453651
91NLK0.58828616
92PRKAA20.58453357
93CSNK1G10.57967206
94GRK10.57563022
95ERBB30.57212838
96MARK20.56971354
97MAP4K20.55712201
98BMPR20.55653478
99DYRK1A0.51347770
100BRSK10.51043811
101CDK190.50815421
102CHUK0.50293042
103MAPK140.48995618
104PRKD20.47597458
105MOS0.45159170
106PRKDC0.44027731
107INSRR0.43653177
108CAMK1D0.43502475
109MAPK100.42594499
110CSNK1D0.42429351
111BTK0.41109549
112ZAK0.40454415
113AKT10.40181236
114MAP3K70.40151330
115GSK3B0.40037848
116PRKAA10.39612400
117OBSCN0.39307026
118TEC0.38168823
119MAPK10.37940571
120DYRK20.37860434
121WNK10.37520475
122RPS6KB10.37388988
123TRPM70.36409327
124FGFR30.35652058
125SGK4940.35536406
126SGK2230.35536406
127STK380.35155410
128VRK20.34535367
129SGK20.34289095
130CSNK1G20.34188146
131PRKG10.34034457
132YES10.34001434
133TIE10.33763522
134KIT0.33672302
135CSNK2A20.32692141
136PIK3CG0.32595997
137PIK3CA0.32531105
138MAP3K40.32483378
139MAPK110.28146236
140CCNB10.27204649
141AURKA0.26755058
142ABL10.25259068
143NTRK20.24990188

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034603.58517492
2Cell cycle_Homo sapiens_hsa041103.49600886
3DNA replication_Homo sapiens_hsa030303.34007186
4Mismatch repair_Homo sapiens_hsa034303.19866907
5Non-homologous end-joining_Homo sapiens_hsa034503.19432327
6Basal transcription factors_Homo sapiens_hsa030223.08331226
7Homologous recombination_Homo sapiens_hsa034402.99730160
8RNA degradation_Homo sapiens_hsa030182.87087180
9RNA transport_Homo sapiens_hsa030132.77478188
10Base excision repair_Homo sapiens_hsa034102.45079804
11mRNA surveillance pathway_Homo sapiens_hsa030152.36673700
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.31719680
13Spliceosome_Homo sapiens_hsa030402.28470174
14Nucleotide excision repair_Homo sapiens_hsa034202.11584120
15Propanoate metabolism_Homo sapiens_hsa006401.97622017
16p53 signaling pathway_Homo sapiens_hsa041151.87582144
17RNA polymerase_Homo sapiens_hsa030201.79262976
18Dorso-ventral axis formation_Homo sapiens_hsa043201.62866893
19Oocyte meiosis_Homo sapiens_hsa041141.61259549
20One carbon pool by folate_Homo sapiens_hsa006701.55953873
21Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.55003088
22Maturity onset diabetes of the young_Homo sapiens_hsa049501.54564940
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.52142224
24Vitamin B6 metabolism_Homo sapiens_hsa007501.47259890
25Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.44094483
26Lysine degradation_Homo sapiens_hsa003101.40338483
27Herpes simplex infection_Homo sapiens_hsa051681.35887969
28Pyrimidine metabolism_Homo sapiens_hsa002401.34493701
29MicroRNAs in cancer_Homo sapiens_hsa052061.33626947
30Transcriptional misregulation in cancer_Homo sapiens_hsa052021.33237593
31Phototransduction_Homo sapiens_hsa047441.29236298
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.28959402
33TGF-beta signaling pathway_Homo sapiens_hsa043501.24795104
34Protein export_Homo sapiens_hsa030601.12905449
35Butanoate metabolism_Homo sapiens_hsa006501.07958454
36HTLV-I infection_Homo sapiens_hsa051661.04781890
37Circadian rhythm_Homo sapiens_hsa047101.03814542
38Pancreatic cancer_Homo sapiens_hsa052121.03635970
39Small cell lung cancer_Homo sapiens_hsa052221.03627737
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.03269184
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.98402660
42Viral carcinogenesis_Homo sapiens_hsa052030.98025543
43Colorectal cancer_Homo sapiens_hsa052100.96486395
44Epstein-Barr virus infection_Homo sapiens_hsa051690.95136008
45Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.93797862
46Primary immunodeficiency_Homo sapiens_hsa053400.92029683
47Purine metabolism_Homo sapiens_hsa002300.91041582
48Linoleic acid metabolism_Homo sapiens_hsa005910.90986072
49alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.89981420
50Olfactory transduction_Homo sapiens_hsa047400.89779434
51Ovarian steroidogenesis_Homo sapiens_hsa049130.88837405
52Notch signaling pathway_Homo sapiens_hsa043300.83886186
53Basal cell carcinoma_Homo sapiens_hsa052170.80623127
54Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.80081050
55Nitrogen metabolism_Homo sapiens_hsa009100.79382180
56Regulation of autophagy_Homo sapiens_hsa041400.78762002
57Adherens junction_Homo sapiens_hsa045200.78521404
58Systemic lupus erythematosus_Homo sapiens_hsa053220.77756025
59Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.77524889
60Prostate cancer_Homo sapiens_hsa052150.77340919
61NF-kappa B signaling pathway_Homo sapiens_hsa040640.76660391
62Selenocompound metabolism_Homo sapiens_hsa004500.76542634
63Thyroid hormone signaling pathway_Homo sapiens_hsa049190.75998300
64Antigen processing and presentation_Homo sapiens_hsa046120.75650876
65Taste transduction_Homo sapiens_hsa047420.75618096
66Wnt signaling pathway_Homo sapiens_hsa043100.73126843
67Chronic myeloid leukemia_Homo sapiens_hsa052200.72728726
68B cell receptor signaling pathway_Homo sapiens_hsa046620.71145900
69Hippo signaling pathway_Homo sapiens_hsa043900.69511950
70Tryptophan metabolism_Homo sapiens_hsa003800.67731610
71FoxO signaling pathway_Homo sapiens_hsa040680.65558626
72Hepatitis B_Homo sapiens_hsa051610.65539590
73Thyroid cancer_Homo sapiens_hsa052160.64773569
74Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.64551942
75Hedgehog signaling pathway_Homo sapiens_hsa043400.63218184
76Measles_Homo sapiens_hsa051620.63091904
77Retinol metabolism_Homo sapiens_hsa008300.62834712
78Pathways in cancer_Homo sapiens_hsa052000.62345377
79mTOR signaling pathway_Homo sapiens_hsa041500.61477724
80Steroid biosynthesis_Homo sapiens_hsa001000.59624866
81Choline metabolism in cancer_Homo sapiens_hsa052310.59153312
82Non-small cell lung cancer_Homo sapiens_hsa052230.58019237
83Acute myeloid leukemia_Homo sapiens_hsa052210.57805041
84Jak-STAT signaling pathway_Homo sapiens_hsa046300.57458792
85Ether lipid metabolism_Homo sapiens_hsa005650.56235681
86Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.54167694
87Melanoma_Homo sapiens_hsa052180.53091261
88Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.53003418
89Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52726214
90Influenza A_Homo sapiens_hsa051640.52580091
91Glucagon signaling pathway_Homo sapiens_hsa049220.51756261
92Ribosome_Homo sapiens_hsa030100.51595050
93Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.50382945
94Peroxisome_Homo sapiens_hsa041460.50351651
95NOD-like receptor signaling pathway_Homo sapiens_hsa046210.50009441
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48659473
97Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.47174599
98Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.46497157
99T cell receptor signaling pathway_Homo sapiens_hsa046600.46068134
100Hematopoietic cell lineage_Homo sapiens_hsa046400.45209242
101Cysteine and methionine metabolism_Homo sapiens_hsa002700.43820625
102Fatty acid degradation_Homo sapiens_hsa000710.42564621
103Endometrial cancer_Homo sapiens_hsa052130.42516134
104Huntingtons disease_Homo sapiens_hsa050160.41888182
105Toxoplasmosis_Homo sapiens_hsa051450.40934250
106Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40069348
107Pyruvate metabolism_Homo sapiens_hsa006200.39936773
108Inositol phosphate metabolism_Homo sapiens_hsa005620.39521525
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37122647
110Prolactin signaling pathway_Homo sapiens_hsa049170.36005298
111Steroid hormone biosynthesis_Homo sapiens_hsa001400.35534015
112Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.35443917
113ABC transporters_Homo sapiens_hsa020100.34710139
114Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.34425257
115VEGF signaling pathway_Homo sapiens_hsa043700.32428958
116Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.31982100
117Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.31672288
118Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31497150
119Intestinal immune network for IgA production_Homo sapiens_hsa046720.30970727
120Fatty acid metabolism_Homo sapiens_hsa012120.29766088
121Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.29560513
122Renal cell carcinoma_Homo sapiens_hsa052110.29527197
123cGMP-PKG signaling pathway_Homo sapiens_hsa040220.28780360
124Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.28532661
125Arachidonic acid metabolism_Homo sapiens_hsa005900.27911962
126Phosphatidylinositol signaling system_Homo sapiens_hsa040700.26629409
127AMPK signaling pathway_Homo sapiens_hsa041520.26220839
128Platelet activation_Homo sapiens_hsa046110.26112239
129Melanogenesis_Homo sapiens_hsa049160.24751301
130Apoptosis_Homo sapiens_hsa042100.24377970
131Tight junction_Homo sapiens_hsa045300.24032753
132MAPK signaling pathway_Homo sapiens_hsa040100.23959191
133Serotonergic synapse_Homo sapiens_hsa047260.23548481
134Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.23185149
135Alcoholism_Homo sapiens_hsa050340.21737838
136Regulation of actin cytoskeleton_Homo sapiens_hsa048100.20869392
137TNF signaling pathway_Homo sapiens_hsa046680.20365379
138Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.20297326
139Glycerophospholipid metabolism_Homo sapiens_hsa005640.20117968

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