MLH3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are implicated in maintaining genomic integrity during DNA replication and after meiotic recombination. The protein encoded by this gene functions as a heterodimer with other family members. Somatic mutations in this gene frequently occur in tumors exhibiting microsatellite instability, and germline mutations have been linked to hereditary nonpolyposis colorectal cancer type 7 (HNPCC7). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein neddylation (GO:0045116)7.83755666
2thrombin receptor signaling pathway (GO:0070493)6.67435521
3negative regulation of norepinephrine secretion (GO:0010700)5.68446385
4blood coagulation, intrinsic pathway (GO:0007597)5.31878038
5neutrophil activation involved in immune response (GO:0002283)5.18915663
6regulation of integrin-mediated signaling pathway (GO:2001044)5.15755256
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.01820099
8cilium or flagellum-dependent cell motility (GO:0001539)4.96956071
9negative regulation of thymocyte apoptotic process (GO:0070244)4.71122792
10regulation of platelet aggregation (GO:0090330)4.63573798
11negative regulation of heart rate (GO:0010459)4.61179572
12regulation of platelet activation (GO:0010543)4.60770279
13negative regulation of protein localization to cell surface (GO:2000009)4.51771602
14positive regulation of endothelial cell differentiation (GO:0045603)4.48513586
15negative regulation of appetite (GO:0032099)4.48201931
16negative regulation of response to food (GO:0032096)4.48201931
17leukocyte migration involved in inflammatory response (GO:0002523)4.47820362
18negative regulation of macrophage derived foam cell differentiation (GO:0010745)4.47682746
19adenosine receptor signaling pathway (GO:0001973)4.45104894
20presynaptic membrane assembly (GO:0097105)4.38650893
21glycosylceramide metabolic process (GO:0006677)4.23324233
22regulation of Golgi to plasma membrane protein transport (GO:0042996)4.16862246
23cardiolipin metabolic process (GO:0032048)4.07890287
24purinergic nucleotide receptor signaling pathway (GO:0035590)4.06534821
25positive regulation of cAMP-mediated signaling (GO:0043950)4.04171409
26low-density lipoprotein particle remodeling (GO:0034374)4.03224232
27ER overload response (GO:0006983)4.01867781
28negative regulation of platelet activation (GO:0010544)3.94993826
29regulation of MHC class II biosynthetic process (GO:0045346)3.93192486
30G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.88123954
31piRNA metabolic process (GO:0034587)3.87870934
32platelet aggregation (GO:0070527)3.87272100
33protein polyglutamylation (GO:0018095)3.80681966
34negative regulation of translation, ncRNA-mediated (GO:0040033)3.80092242
35regulation of translation, ncRNA-mediated (GO:0045974)3.80092242
36negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.80092242
37regulation of norepinephrine secretion (GO:0014061)3.77268756
38negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.75925956
39axonemal dynein complex assembly (GO:0070286)3.74994483
40early endosome to late endosome transport (GO:0045022)3.73019679
41phospholipid homeostasis (GO:0055091)3.70768594
42positive regulation of protein homodimerization activity (GO:0090073)3.70091817
43protein palmitoylation (GO:0018345)3.68253965
44endoplasmic reticulum organization (GO:0007029)3.65785503
45negative regulation of catecholamine secretion (GO:0033604)3.64866317
46postsynaptic membrane organization (GO:0001941)3.64706031
47high-density lipoprotein particle remodeling (GO:0034375)3.61077050
48regulation of lipoprotein metabolic process (GO:0050746)3.60853598
49beta-amyloid metabolic process (GO:0050435)3.58696673
50reverse cholesterol transport (GO:0043691)3.57990587
51dopamine transport (GO:0015872)3.57271438
52adenosine metabolic process (GO:0046085)3.56439182
53termination of G-protein coupled receptor signaling pathway (GO:0038032)3.53529980
54long-chain fatty acid biosynthetic process (GO:0042759)3.52404748
55fatty acid homeostasis (GO:0055089)3.51807654
56nuclear pore complex assembly (GO:0051292)3.51450060
57positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.49131437
58positive regulation of mitotic sister chromatid separation (GO:1901970)3.49131437
59positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.49131437
60regulation of female receptivity (GO:0045924)3.47507762
61regulation of macrophage derived foam cell differentiation (GO:0010743)3.45336759
62* synaptonemal complex assembly (GO:0007130)3.45187974
63regulation of memory T cell differentiation (GO:0043380)3.42470157
64presynaptic membrane organization (GO:0097090)3.39877987
65motile cilium assembly (GO:0044458)3.37543055
66nuclear pore organization (GO:0006999)3.36647661
67regulation of protein polyubiquitination (GO:1902914)3.36131621
68microtubule depolymerization (GO:0007019)3.33881993
69regulation of glucokinase activity (GO:0033131)3.30927158
70regulation of hexokinase activity (GO:1903299)3.30927158
71positive regulation of muscle hypertrophy (GO:0014742)3.30526039
72positive regulation of cardiac muscle hypertrophy (GO:0010613)3.30526039
73NLS-bearing protein import into nucleus (GO:0006607)3.29293151
74platelet formation (GO:0030220)3.27647790
75pyrimidine nucleoside catabolic process (GO:0046135)3.26450616
76mitotic sister chromatid cohesion (GO:0007064)3.24009109
77termination of signal transduction (GO:0023021)3.24005693
78neutrophil activation (GO:0042119)3.23134077
79* synaptonemal complex organization (GO:0070193)3.21674060
80glycosphingolipid catabolic process (GO:0046479)3.20298365
81regulation of helicase activity (GO:0051095)3.20246190
82positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc3.18049494
83negative regulation of homotypic cell-cell adhesion (GO:0034111)3.17556065
84chemosensory behavior (GO:0007635)3.17350673
85mitotic chromosome condensation (GO:0007076)3.16369340
86axoneme assembly (GO:0035082)3.15315049
87regulation of endothelial cell differentiation (GO:0045601)3.15243216
88negative regulation of heart contraction (GO:0045822)3.14995924
89positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.12832645
90* male meiosis (GO:0007140)3.12781897
91intra-S DNA damage checkpoint (GO:0031573)3.12600315
92positive regulation of Rho protein signal transduction (GO:0035025)3.11569746
93platelet degranulation (GO:0002576)3.11164198
94regulation of RNA export from nucleus (GO:0046831)3.10796319
95regulation of response to food (GO:0032095)3.10557515
96lipoxygenase pathway (GO:0019372)3.09906443
97tyrosine metabolic process (GO:0006570)3.08649807
98insulin-like growth factor receptor signaling pathway (GO:0048009)3.07993132
99activation of Rac GTPase activity (GO:0032863)3.06316242
100DNA methylation involved in gamete generation (GO:0043046)3.06058511
101regulation of megakaryocyte differentiation (GO:0045652)3.05574440
102microtubule cytoskeleton organization involved in mitosis (GO:1902850)3.02440534
103purinergic receptor signaling pathway (GO:0035587)3.01421072
104dicarboxylic acid catabolic process (GO:0043649)3.00491212
105epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.99433283
106regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.99232649
107glucocorticoid receptor signaling pathway (GO:0042921)2.96914791
108megakaryocyte development (GO:0035855)2.96842002
109positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.96369466
110lactate metabolic process (GO:0006089)2.96164394
111positive regulation of mast cell activation (GO:0033005)2.94038884
112plasma membrane fusion (GO:0045026)2.92700183
113vesicle targeting (GO:0006903)2.92668102
114positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.92561702
115glycoside metabolic process (GO:0016137)2.92156197
116carnitine shuttle (GO:0006853)2.91427702
117retinal cone cell development (GO:0046549)2.89002260
118folic acid-containing compound biosynthetic process (GO:0009396)2.88505137
119erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.87764609
120L-phenylalanine catabolic process (GO:0006559)2.87764609
121platelet activation (GO:0030168)2.87764573
122ceramide catabolic process (GO:0046514)2.86765670
123positive regulation of receptor recycling (GO:0001921)2.85678240
124regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.84893367
125positive regulation of systemic arterial blood pressure (GO:0003084)2.84816018
126glycolipid catabolic process (GO:0019377)2.84276329
127female mating behavior (GO:0060180)2.84018997
128sequestering of actin monomers (GO:0042989)2.83640945
129regulation of inositol phosphate biosynthetic process (GO:0010919)2.83387449
130positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.83376705
131centriole assembly (GO:0098534)2.82944844
132fatty acid elongation (GO:0030497)2.80159733
133amine catabolic process (GO:0009310)2.80082787
134cellular biogenic amine catabolic process (GO:0042402)2.80082787
135polyamine biosynthetic process (GO:0006596)2.79786735
136positive regulation of chromosome segregation (GO:0051984)2.79734475
137synaptic vesicle maturation (GO:0016188)2.79028959
138regulation of cilium movement (GO:0003352)2.79025121
139aspartate family amino acid catabolic process (GO:0009068)2.78949718
140tonic smooth muscle contraction (GO:0014820)2.78567924
141positive regulation of granulocyte differentiation (GO:0030854)2.77373489
142intraciliary transport (GO:0042073)2.76238958
143relaxation of smooth muscle (GO:0044557)2.76215482
144regulation of appetite (GO:0032098)2.75201654
145granulocyte differentiation (GO:0030851)2.73974100
146regulation of pigment cell differentiation (GO:0050932)2.73475874
147limb development (GO:0060173)2.72900479
148appendage development (GO:0048736)2.72900479
149myelin assembly (GO:0032288)2.72654156
150activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.72608183
151fusion of sperm to egg plasma membrane (GO:0007342)2.72252624
152ether lipid metabolic process (GO:0046485)2.72187970
153insulin secretion (GO:0030073)2.71373406
154meiotic chromosome segregation (GO:0045132)2.70623914
155negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.70090182
156regulation of integrin activation (GO:0033623)2.69508721
157Golgi to endosome transport (GO:0006895)2.69351982
158regulation of energy homeostasis (GO:2000505)2.68365643
159IMP biosynthetic process (GO:0006188)2.67831399
160monoamine transport (GO:0015844)2.67460503
161regulation of meiosis I (GO:0060631)2.67246773
162positive regulation of macrophage differentiation (GO:0045651)2.66183103
163angiogenesis involved in wound healing (GO:0060055)2.65987278
164negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.64832161
165negative regulation of T-helper cell differentiation (GO:0045623)2.64832161
166negative regulation of G-protein coupled receptor protein signaling pathway (GO:0045744)2.63531019
167calcium ion-dependent exocytosis (GO:0017156)2.62855764
168replicative senescence (GO:0090399)2.62423116
169negative regulation of calcium ion transmembrane transport (GO:1903170)2.61422059
170protein targeting to Golgi (GO:0000042)2.60797324
171endoderm development (GO:0007492)2.60676044
172import into cell (GO:0098657)2.60369356
173spindle assembly involved in mitosis (GO:0090307)2.60278137
174regulation of gene expression by genetic imprinting (GO:0006349)2.58192283
175tRNA methylation (GO:0030488)2.57776461
176monoubiquitinated protein deubiquitination (GO:0035520)2.57733525
177histone H3-K9 methylation (GO:0051567)2.56481679
178negative regulation of histone methylation (GO:0031061)2.55825749
179male meiosis I (GO:0007141)2.54883907
180sister chromatid cohesion (GO:0007062)2.54107630
181* chromosome organization involved in meiosis (GO:0070192)2.53151693
182membrane repolarization during action potential (GO:0086011)2.52533481
183centrosome duplication (GO:0051298)2.52495395
184endosome to melanosome transport (GO:0035646)2.52122487
185endosome to pigment granule transport (GO:0043485)2.52122487
186membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.51628198
187regulation of nucleobase-containing compound transport (GO:0032239)2.50481584
188histone H3-K4 trimethylation (GO:0080182)2.48878455
189regulation of short-term neuronal synaptic plasticity (GO:0048172)2.47098209
190histone H3-K9 modification (GO:0061647)2.46834356
191sperm motility (GO:0030317)2.45986396
192vesicle transport along microtubule (GO:0047496)2.44019326
193fatty acid transmembrane transport (GO:1902001)2.43069274
194negative regulation of meiosis (GO:0045835)2.43060222
195positive regulation of glycolytic process (GO:0045821)2.42667923

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.12353733
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.45995815
3GBX2_23144817_ChIP-Seq_PC3_Human3.26196493
4SALL1_21062744_ChIP-ChIP_HESCs_Human2.90440720
5E2F7_22180533_ChIP-Seq_HELA_Human2.82879559
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.71835829
7TAF15_26573619_Chip-Seq_HEK293_Human2.67479742
8SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.66624177
9RBPJ_22232070_ChIP-Seq_NCS_Mouse2.61737196
10SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.58881041
11RCOR2_21632747_ChIP-Seq_MESCs_Mouse2.54186516
12GATA1_22025678_ChIP-Seq_K562_Human2.47961985
13KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.47648050
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.46372047
15CDX2_19796622_ChIP-Seq_MESCs_Mouse2.43580813
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.42071531
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.41875451
18LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.31725002
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.30819012
20BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.29586141
21VDR_22108803_ChIP-Seq_LS180_Human2.28449443
22FLI1_27457419_Chip-Seq_LIVER_Mouse2.08659033
23IGF1R_20145208_ChIP-Seq_DFB_Human2.07165904
24EWS_26573619_Chip-Seq_HEK293_Human2.06296410
25SCL_19346495_ChIP-Seq_HPC-7_Human2.06041976
26SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.05508298
27FUS_26573619_Chip-Seq_HEK293_Human2.03565498
28DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.01367052
29POU3F2_20337985_ChIP-ChIP_501MEL_Human1.99133391
30HTT_18923047_ChIP-ChIP_STHdh_Human1.91754879
31TCF4_23295773_ChIP-Seq_U87_Human1.91019104
32DROSHA_22980978_ChIP-Seq_HELA_Human1.83804819
33STAT3_23295773_ChIP-Seq_U87_Human1.82348185
34FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.81946750
35TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.81941121
36RARB_27405468_Chip-Seq_BRAIN_Mouse1.81540814
37P300_19829295_ChIP-Seq_ESCs_Human1.80825599
38* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.78738836
39CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.74554377
40UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.68074283
41* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.64034417
42* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.64034417
43REST_21632747_ChIP-Seq_MESCs_Mouse1.61543823
44TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.58842148
45SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.56514698
46BCAT_22108803_ChIP-Seq_LS180_Human1.55776250
47PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.55719602
48PCGF2_27294783_Chip-Seq_ESCs_Mouse1.55481298
49MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.55162146
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.53683476
51NANOG_18555785_Chip-Seq_ESCs_Mouse1.53662288
52SMAD4_21799915_ChIP-Seq_A2780_Human1.52087715
53KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.50512214
54KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.50512214
55KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.50512214
56MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.49812937
57TCF4_18268006_ChIP-ChIP_LS174T_Human1.47676181
58RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46580706
59NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.46406041
60SUZ12_27294783_Chip-Seq_NPCs_Mouse1.44872780
61Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.44444516
62YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.42955863
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.41955787
64GATA2_21666600_ChIP-Seq_HMVEC_Human1.41568452
65ZFP57_27257070_Chip-Seq_ESCs_Mouse1.40623520
66CTBP2_25329375_ChIP-Seq_LNCAP_Human1.40573694
67NFE2_27457419_Chip-Seq_LIVER_Mouse1.38391441
68SALL4_22934838_ChIP-ChIP_CD34+_Human1.36308927
69CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.35660065
70E2F1_18555785_Chip-Seq_ESCs_Mouse1.35592235
71GATA2_19941826_ChIP-Seq_K562_Human1.35163919
72ELK4_26923725_Chip-Seq_MESODERM_Mouse1.35015555
73CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32295401
74AR_19668381_ChIP-Seq_PC3_Human1.32056295
75AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.31494418
76SOX2_21211035_ChIP-Seq_LN229_Gbm1.30526100
77CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.27894188
78PCGF2_27294783_Chip-Seq_NPCs_Mouse1.27362186
79CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.25963683
80FOXM1_23109430_ChIP-Seq_U2OS_Human1.25800465
81TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.24048772
82EZH2_27294783_Chip-Seq_NPCs_Mouse1.23936218
83SMAD_19615063_ChIP-ChIP_OVARY_Human1.23804080
84FLI1_21867929_ChIP-Seq_TH2_Mouse1.23239721
85GATA1_19941826_ChIP-Seq_K562_Human1.22051721
86STAT3_18555785_Chip-Seq_ESCs_Mouse1.20200646
87FOXM1_26456572_ChIP-Seq_MCF-7_Human1.19483411
88P53_22387025_ChIP-Seq_ESCs_Mouse1.18980646
89NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.17825539
90YAP1_20516196_ChIP-Seq_MESCs_Mouse1.17033294
91ARNT_22903824_ChIP-Seq_MCF-7_Human1.16720659
92AR_21572438_ChIP-Seq_LNCaP_Human1.15280668
93SOX2_18555785_Chip-Seq_ESCs_Mouse1.15228384
94CBP_20019798_ChIP-Seq_JUKART_Human1.14276893
95IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14276893
96IRF1_19129219_ChIP-ChIP_H3396_Human1.13698910
97ZNF217_24962896_ChIP-Seq_MCF-7_Human1.13535572
98CMYC_18555785_Chip-Seq_ESCs_Mouse1.13106914
99GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12315516
100SOX2_19829295_ChIP-Seq_ESCs_Human1.12201068
101NANOG_19829295_ChIP-Seq_ESCs_Human1.12201068
102MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.11848223
103ER_23166858_ChIP-Seq_MCF-7_Human1.11844390
104MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.11821231
105P300_18555785_Chip-Seq_ESCs_Mouse1.10984891
106AR_25329375_ChIP-Seq_VCAP_Human1.10601973
107* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09413818
108* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09073292
109NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08713328
110EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.08646032
111SUZ12_18555785_Chip-Seq_ESCs_Mouse1.08393816
112OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07915441
113OCT4_18555785_Chip-Seq_ESCs_Mouse1.07671203
114TBL1_22424771_ChIP-Seq_293T_Human1.07352865
115KLF4_18555785_Chip-Seq_ESCs_Mouse1.06828533
116* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06324598
117* FOXA2_19822575_ChIP-Seq_HepG2_Human1.05582861
118EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.05407495
119TAL1_26923725_Chip-Seq_HPCs_Mouse1.05077170
120LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.04543359
121STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.04407467
122TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.04376788
123EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.03869104
124ETV1_20927104_ChIP-Seq_GIST48_Human1.03649202
125RUNX1_27457419_Chip-Seq_LIVER_Mouse1.03042050
126CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.02914853
127ZNF274_21170338_ChIP-Seq_K562_Hela1.02640704
128REST_18959480_ChIP-ChIP_MESCs_Mouse1.01840742
129OCT4_21477851_ChIP-Seq_ESCs_Mouse1.01735600
130TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00880532
131RUNX2_22187159_ChIP-Seq_PCA_Human1.00764321
132RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.00311385
133LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99214920
134ZFX_18555785_Chip-Seq_ESCs_Mouse0.99165882
135POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.98829383
136TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98829383
137SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.98644974
138CDX2_22108803_ChIP-Seq_LS180_Human0.98554869
139NMYC_18555785_Chip-Seq_ESCs_Mouse0.98211015
140FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.97378139
141IRF8_21731497_ChIP-ChIP_J774_Mouse0.97100957
142TP53_16413492_ChIP-PET_HCT116_Human0.96594833
143TCF4_22108803_ChIP-Seq_LS180_Human0.95061877
144CRX_20693478_ChIP-Seq_RETINA_Mouse0.93772049
145FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.93423343
146CTCF_18555785_Chip-Seq_ESCs_Mouse0.92895364
147* SMAD4_21741376_ChIP-Seq_EPCs_Human0.92688207

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology8.84943832
2MP0003787_abnormal_imprinting4.75321996
3MP0008877_abnormal_DNA_methylation4.68895770
4MP0004264_abnormal_extraembryonic_tissu4.04321682
5MP0003890_abnormal_embryonic-extraembry3.55701361
6MP0005646_abnormal_pituitary_gland3.31454767
7MP0003283_abnormal_digestive_organ2.96920652
8MP0000465_gastrointestinal_hemorrhage2.69396693
9MP0005410_abnormal_fertilization2.69196074
10MP0004084_abnormal_cardiac_muscle2.65063206
11MP0000230_abnormal_systemic_arterial2.57720081
12MP0004043_abnormal_pH_regulation2.44555260
13MP0008872_abnormal_physiological_respon2.35850993
14MP0002736_abnormal_nociception_after2.29936259
15MP0004859_abnormal_synaptic_plasticity2.28797155
16MP0001986_abnormal_taste_sensitivity2.25800832
17MP0006072_abnormal_retinal_apoptosis2.21856599
18MP0009780_abnormal_chondrocyte_physiolo2.17022003
19MP0008775_abnormal_heart_ventricle2.07759726
20MP0003724_increased_susceptibility_to2.05953725
21MP0000569_abnormal_digit_pigmentation2.05829666
22MP0004215_abnormal_myocardial_fiber2.00028080
23MP0004036_abnormal_muscle_relaxation1.98912515
24MP0002877_abnormal_melanocyte_morpholog1.90690367
25MP0004885_abnormal_endolymph1.88305747
26MP0008004_abnormal_stomach_pH1.86546101
27MP0005253_abnormal_eye_physiology1.84183992
28MP0004270_analgesia1.78459641
29MP0003136_yellow_coat_color1.78190972
30MP0005084_abnormal_gallbladder_morpholo1.76338117
31MP0005167_abnormal_blood-brain_barrier1.74764037
32MP0003868_abnormal_feces_composition1.74254494
33MP0000015_abnormal_ear_pigmentation1.73940882
34MP0000383_abnormal_hair_follicle1.72925344
35MP0003806_abnormal_nucleotide_metabolis1.72182486
36MP0002102_abnormal_ear_morphology1.70047783
37MP0000372_irregular_coat_pigmentation1.67608263
38MP0004510_myositis1.65646843
39MP0005076_abnormal_cell_differentiation1.64428647
40MP0002909_abnormal_adrenal_gland1.64292146
41MP0001968_abnormal_touch/_nociception1.63182067
42* MP0003698_abnormal_male_reproductive1.62477238
43MP0010094_abnormal_chromosome_stability1.62087242
44MP0005551_abnormal_eye_electrophysiolog1.60605339
45MP0010329_abnormal_lipoprotein_level1.60040170
46MP0001879_abnormal_lymphatic_vessel1.57327170
47MP0003121_genomic_imprinting1.56986808
48MP0005220_abnormal_exocrine_pancreas1.54896914
49MP0008057_abnormal_DNA_replication1.54836109
50MP0003195_calcinosis1.54250360
51MP0006276_abnormal_autonomic_nervous1.51414676
52MP0004130_abnormal_muscle_cell1.48676694
53MP0001944_abnormal_pancreas_morphology1.48647670
54MP0003635_abnormal_synaptic_transmissio1.45876583
55* MP0001929_abnormal_gametogenesis1.42964453
56MP0004484_altered_response_of1.42137955
57MP0000579_abnormal_nail_morphology1.41971973
58MP0003300_gastrointestinal_ulcer1.41134287
59MP0002009_preneoplasia1.40704956
60MP0002693_abnormal_pancreas_physiology1.40199422
61MP0009697_abnormal_copulation1.40101206
62MP0005171_absent_coat_pigmentation1.40091642
63MP0005174_abnormal_tail_pigmentation1.37688896
64MP0003638_abnormal_response/metabolism_1.34073290
65MP0005365_abnormal_bile_salt1.33098361
66MP0000343_altered_response_to1.32938868
67MP0003879_abnormal_hair_cell1.32625814
68MP0002064_seizures1.30964591
69MP0002272_abnormal_nervous_system1.28965217
70MP0002229_neurodegeneration1.27897735
71MP0003252_abnormal_bile_duct1.26547930
72MP0003632_abnormal_nervous_system1.25695888
73MP0005083_abnormal_biliary_tract1.24874288
74MP0001177_atelectasis1.24868936
75MP0002078_abnormal_glucose_homeostasis1.23951840
76* MP0002210_abnormal_sex_determination1.22995618
77MP0002733_abnormal_thermal_nociception1.20004307
78MP0004133_heterotaxia1.19491958
79MP0001299_abnormal_eye_distance/1.18713384
80MP0002063_abnormal_learning/memory/cond1.17881607
81MP0005085_abnormal_gallbladder_physiolo1.17007844
82MP0001486_abnormal_startle_reflex1.14498090
83MP0002822_catalepsy1.14464775
84MP0003183_abnormal_peptide_metabolism1.14125030
85MP0001835_abnormal_antigen_presentation1.14048223
86MP0002735_abnormal_chemical_nociception1.13905059
87MP0003566_abnormal_cell_adhesion1.11219453
88MP0005409_darkened_coat_color1.10815296
89MP0009046_muscle_twitch1.10110247
90MP0001663_abnormal_digestive_system1.09657424
91MP0003137_abnormal_impulse_conducting1.09129827
92MP0003045_fibrosis1.08841801
93MP0000013_abnormal_adipose_tissue1.08194198
94MP0001756_abnormal_urination1.05571150
95MP0006054_spinal_hemorrhage1.05060223
96MP0005620_abnormal_muscle_contractility1.04796503
97MP0003633_abnormal_nervous_system1.04473248
98MP0001970_abnormal_pain_threshold1.03270966
99MP0003631_nervous_system_phenotype1.02542586
100MP0002972_abnormal_cardiac_muscle1.01721405
101MP0005187_abnormal_penis_morphology1.01559580
102MP0000003_abnormal_adipose_tissue1.01490752
103* MP0001145_abnormal_male_reproductive1.00643176
104MP0001440_abnormal_grooming_behavior0.99854694
105MP0002837_dystrophic_cardiac_calcinosis0.99567740
106MP0002572_abnormal_emotion/affect_behav0.99554568
107MP0004142_abnormal_muscle_tone0.99188700
108MP0003718_maternal_effect0.97926088
109MP0000955_abnormal_spinal_cord0.97407961
110MP0002557_abnormal_social/conspecific_i0.96981835
111MP0002971_abnormal_brown_adipose0.96174690
112MP0000249_abnormal_blood_vessel0.96006160
113MP0002928_abnormal_bile_duct0.95948322
114MP0004134_abnormal_chest_morphology0.95431357
115MP0003828_pulmonary_edema0.94879137
116MP0005310_abnormal_salivary_gland0.94615999
117MP0003111_abnormal_nucleus_morphology0.94070259
118MP0010155_abnormal_intestine_physiology0.92852692
119MP0002876_abnormal_thyroid_physiology0.92480286
120MP0005647_abnormal_sex_gland0.92340130
121MP0008058_abnormal_DNA_repair0.89858091
122MP0000920_abnormal_myelination0.89773360
123MP0003690_abnormal_glial_cell0.88945519
124MP0001730_embryonic_growth_arrest0.88645642
125MP0009642_abnormal_blood_homeostasis0.87559985
126MP0010678_abnormal_skin_adnexa0.87544834
127MP0005423_abnormal_somatic_nervous0.87226052
128MP0002653_abnormal_ependyma_morphology0.85671160
129MP0001661_extended_life_span0.84577814
130MP0002269_muscular_atrophy0.84264911
131* MP0002161_abnormal_fertility/fecundity0.83779319
132MP0001765_abnormal_ion_homeostasis0.82606829
133MP0003011_delayed_dark_adaptation0.82408680
134MP0010386_abnormal_urinary_bladder0.81956068
135MP0001545_abnormal_hematopoietic_system0.81939051
136MP0005397_hematopoietic_system_phenotyp0.81939051
137MP0005391_vision/eye_phenotype0.80850691
138MP0005332_abnormal_amino_acid0.80212220
139* MP0000653_abnormal_sex_gland0.80181790
140MP0005448_abnormal_energy_balance0.80029688
141MP0005535_abnormal_body_temperature0.79950927
142MP0009745_abnormal_behavioral_response0.79144987
143MP0001851_eye_inflammation0.77950182
144MP0001664_abnormal_digestion0.77252705
145MP0006035_abnormal_mitochondrial_morpho0.76965938
146MP0002638_abnormal_pupillary_reflex0.76558451
147MP0002139_abnormal_hepatobiliary_system0.76514679
148MP0005330_cardiomyopathy0.76410849
149MP0003634_abnormal_glial_cell0.76005454
150MP0000462_abnormal_digestive_system0.75610518
151MP0003172_abnormal_lysosome_physiology0.74418557
152MP0003656_abnormal_erythrocyte_physiolo0.74285641
153MP0002084_abnormal_developmental_patter0.74045679
154MP0010307_abnormal_tumor_latency0.72329000
155MP0002882_abnormal_neuron_morphology0.72003638
156MP0001485_abnormal_pinna_reflex0.70958442
157MP0005367_renal/urinary_system_phenotyp0.70528783
158MP0000516_abnormal_urinary_system0.70528783
159MP0002095_abnormal_skin_pigmentation0.70064784
160MP0001984_abnormal_olfaction0.69554651
161MP0003866_abnormal_defecation0.69470339
162MP0002118_abnormal_lipid_homeostasis0.69153338
163MP0009703_decreased_birth_body0.68377485
164MP0004085_abnormal_heartbeat0.67831017
165MP0000358_abnormal_cell_content/0.67465083
166MP0009763_increased_sensitivity_to0.66054229
167MP0002152_abnormal_brain_morphology0.65659235
168MP0000778_abnormal_nervous_system0.65206812
169MP0002128_abnormal_blood_circulation0.63489678
170MP0002067_abnormal_sensory_capabilities0.63387587
171MP0002398_abnormal_bone_marrow0.62137371

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)9.72219448
2Increased mean platelet volume (HP:0011877)9.16005026
3Menorrhagia (HP:0000132)9.04258298
4Abnormal platelet volume (HP:0011876)8.44044496
5Petechiae (HP:0000967)7.62714390
6Purpura (HP:0000979)6.88479166
7Epistaxis (HP:0000421)6.26065654
8Hyperlipoproteinemia (HP:0010980)5.63625091
9Gingival bleeding (HP:0000225)5.44428881
10Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.92382615
11Impaired vibration sensation in the lower limbs (HP:0002166)4.75350738
12Acanthocytosis (HP:0001927)4.39263410
13Tubulointerstitial nephritis (HP:0001970)4.37845073
14Impaired platelet aggregation (HP:0003540)3.88546353
15Abnormal platelet function (HP:0011869)3.88546353
16Dynein arm defect of respiratory motile cilia (HP:0012255)3.76231672
17Absent/shortened dynein arms (HP:0200106)3.76231672
18Poikilocytosis (HP:0004447)3.75831109
19Hyperinsulinemic hypoglycemia (HP:0000825)3.75248655
20Abnormality of the pancreatic islet cells (HP:0006476)3.70141728
21Abnormality of endocrine pancreas physiology (HP:0012093)3.70141728
22Ankle clonus (HP:0011448)3.45436815
23Pancreatic islet-cell hyperplasia (HP:0004510)3.39989318
24Split foot (HP:0001839)3.34690965
25Spontaneous hematomas (HP:0007420)3.31780543
26Chronic hepatic failure (HP:0100626)3.28985981
27Conjunctival telangiectasia (HP:0000524)3.26547280
28Decreased central vision (HP:0007663)3.16586861
29Genetic anticipation (HP:0003743)3.14702899
30Thyroid-stimulating hormone excess (HP:0002925)3.11139660
31Impaired vibratory sensation (HP:0002495)3.09715320
32Insulin-resistant diabetes mellitus (HP:0000831)3.08688359
33Abnormal auditory evoked potentials (HP:0006958)3.06301707
34Abnormal pancreas size (HP:0012094)3.04382887
35Chronic bronchitis (HP:0004469)3.03380363
36Hyperkalemia (HP:0002153)2.97683485
37Volvulus (HP:0002580)2.95390536
38Papillary thyroid carcinoma (HP:0002895)2.86098950
39Abnormal pupillary function (HP:0007686)2.84220187
40Abnormal respiratory motile cilium physiology (HP:0012261)2.83528828
41Abnormality of the labia minora (HP:0012880)2.82072760
42Abnormality of the common coagulation pathway (HP:0010990)2.79676863
43Intestinal atresia (HP:0011100)2.77096477
44Paralysis (HP:0003470)2.73932532
45Abnormality of the vasculature of the conjunctiva (HP:0008054)2.73449126
46Increased density of long bones (HP:0006392)2.66103771
47Chromosomal breakage induced by crosslinking agents (HP:0003221)2.63922560
48Joint hemorrhage (HP:0005261)2.58415652
49Abnormality of ocular smooth pursuit (HP:0000617)2.58347606
50Chromsome breakage (HP:0040012)2.57841644
51Bruising susceptibility (HP:0000978)2.57538307
52Ependymoma (HP:0002888)2.57162442
53Degeneration of the lateral corticospinal tracts (HP:0002314)2.53200414
54Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.53200414
55Carpal bone hypoplasia (HP:0001498)2.52221850
56Abnormality of the lower motor neuron (HP:0002366)2.52153187
57Glioma (HP:0009733)2.51504298
58Clonus (HP:0002169)2.47594912
59Spastic gait (HP:0002064)2.45634022
60Truncal obesity (HP:0001956)2.44960382
61Abnormality of the heme biosynthetic pathway (HP:0010472)2.43971960
62Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.40840142
63Gaze-evoked nystagmus (HP:0000640)2.39605730
64Recurrent otitis media (HP:0000403)2.39237582
65Small epiphyses (HP:0010585)2.37993448
66Abnormality of lateral ventricle (HP:0030047)2.37023402
67Abnormality of the astrocytes (HP:0100707)2.34696253
68Astrocytoma (HP:0009592)2.34696253
69Oligodactyly (hands) (HP:0001180)2.33041384
70Hypoglycemic seizures (HP:0002173)2.32464670
71Febrile seizures (HP:0002373)2.31733310
72Progressive cerebellar ataxia (HP:0002073)2.31655172
73Abnormality of the corticospinal tract (HP:0002492)2.31480164
74Scanning speech (HP:0002168)2.29636214
75Bundle branch block (HP:0011710)2.29569543
76Myopathic facies (HP:0002058)2.28224928
77Poor speech (HP:0002465)2.28065829
78Renal cortical cysts (HP:0000803)2.26845505
79Myoglobinuria (HP:0002913)2.26566938
80Resting tremor (HP:0002322)2.25313985
81Abnormality of homocysteine metabolism (HP:0010919)2.23907744
82Homocystinuria (HP:0002156)2.23907744
83Broad distal phalanx of finger (HP:0009836)2.21883593
84Dyschromatopsia (HP:0007641)2.19099168
85Neoplasm of the oral cavity (HP:0100649)2.16991486
86Rhinitis (HP:0012384)2.15565130
87Thyroid carcinoma (HP:0002890)2.14803235
88Joint swelling (HP:0001386)2.14595183
89Lower limb muscle weakness (HP:0007340)2.13955365
90Urinary bladder sphincter dysfunction (HP:0002839)2.12174700
913-Methylglutaconic aciduria (HP:0003535)2.11833876
92Postural instability (HP:0002172)2.11307378
93Dysmetria (HP:0001310)2.10068803
94Limb hypertonia (HP:0002509)2.10057011
95Ketoacidosis (HP:0001993)2.10049022
96Acute hepatic failure (HP:0006554)2.09820907
97Abnormality of the renal cortex (HP:0011035)2.09548889
98Abnormal respiratory epithelium morphology (HP:0012253)2.09472504
99Abnormal respiratory motile cilium morphology (HP:0005938)2.09472504
100Urinary urgency (HP:0000012)2.06816238
101Infertility (HP:0000789)2.06399484
102Hypoglycemic coma (HP:0001325)2.05054234
103Epileptiform EEG discharges (HP:0011182)1.99685877
104Aplasia/Hypoplasia of the uvula (HP:0010293)1.98827016
105Polyphagia (HP:0002591)1.98695316
106EEG with generalized epileptiform discharges (HP:0011198)1.97576863
107Testicular neoplasm (HP:0010788)1.97426098
108Generalized aminoaciduria (HP:0002909)1.97345799
109Hyperglycemia (HP:0003074)1.96947684
110Abnormality of chromosome stability (HP:0003220)1.96743797
111Arthropathy (HP:0003040)1.96100530
112Decreased circulating renin level (HP:0003351)1.93338668
113Abnormality of the fingertips (HP:0001211)1.92462546
114Abnormality of the salivary glands (HP:0010286)1.90430311
115Abnormality of alanine metabolism (HP:0010916)1.89575551
116Hyperalaninemia (HP:0003348)1.89575551
117Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.89575551
118Abnormal ciliary motility (HP:0012262)1.89358588
119Hypsarrhythmia (HP:0002521)1.88828515
120Type II diabetes mellitus (HP:0005978)1.85055577
121Enlarged kidneys (HP:0000105)1.84703543
122Optic nerve hypoplasia (HP:0000609)1.84697645
123Spontaneous abortion (HP:0005268)1.84494135
124Hypoplasia of the fovea (HP:0007750)1.81032036
125Aplasia/Hypoplasia of the fovea (HP:0008060)1.81032036
126Symptomatic seizures (HP:0011145)1.80374287
127Upper limb muscle weakness (HP:0003484)1.79947096
128Gastrointestinal atresia (HP:0002589)1.79924560
129Abnormality of aromatic amino acid family metabolism (HP:0004338)1.79496741
130Urethral obstruction (HP:0000796)1.79115760
131Attenuation of retinal blood vessels (HP:0007843)1.78977977
132Irregular vertebral endplates (HP:0003301)1.76399203
133Agitation (HP:0000713)1.75822888
134Prominent nose (HP:0000448)1.75543222
135Breast carcinoma (HP:0003002)1.75225690
136* Biliary tract neoplasm (HP:0100574)1.75186237
137Hypoplastic iliac wings (HP:0002866)1.74584586
138Abnormality of the prostate (HP:0008775)1.73783175
139Congenital sensorineural hearing impairment (HP:0008527)1.72451907
140Delayed puberty (HP:0000823)1.70788868
141Gonadal dysgenesis (HP:0000133)1.70768425
142Medial flaring of the eyebrow (HP:0010747)1.69978062
143Autoimmune hemolytic anemia (HP:0001890)1.69128455
144Long clavicles (HP:0000890)1.68987544
145Abnormality of the preputium (HP:0100587)1.67656830
146Lissencephaly (HP:0001339)1.67579011
147Epidermoid cyst (HP:0200040)1.67013920
148Abnormality of the renal medulla (HP:0100957)1.66988261
149Atonic seizures (HP:0010819)1.66511776
150Agnosia (HP:0010524)1.65954063
151Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.65762963
152Abnormality of the fovea (HP:0000493)1.64405661
153Poor coordination (HP:0002370)1.64335529
154Nausea (HP:0002018)1.64157248
155Abnormality of transition element cation homeostasis (HP:0011030)1.63529621
156Hyperglycinemia (HP:0002154)1.63382867
157Xanthomatosis (HP:0000991)1.63088195
158Embryonal neoplasm (HP:0002898)1.62944426
159Central scotoma (HP:0000603)1.62904836
160Scotoma (HP:0000575)1.62550639
161Pancreatic cysts (HP:0001737)1.61066074
162Tinnitus (HP:0000360)1.60255919
163Nephronophthisis (HP:0000090)1.60019336
164Hyperthyroidism (HP:0000836)1.59313099
165Mitral stenosis (HP:0001718)1.58410962
166Hepatosplenomegaly (HP:0001433)1.58057188
167Proximal tubulopathy (HP:0000114)1.57392602
168Pancreatic fibrosis (HP:0100732)1.54485827
169Hyperventilation (HP:0002883)1.53655727
170Abnormal drinking behavior (HP:0030082)1.53472449
171Polydipsia (HP:0001959)1.53472449
172Basal ganglia calcification (HP:0002135)1.52712624
173Ventricular fibrillation (HP:0001663)1.52585815
174Abnormality of midbrain morphology (HP:0002418)1.52378668
175Molar tooth sign on MRI (HP:0002419)1.52378668
176Abolished electroretinogram (ERG) (HP:0000550)1.52199948
177Intellectual disability, profound (HP:0002187)1.52098882
178Fair hair (HP:0002286)1.52036911
179Tongue fasciculations (HP:0001308)1.52010079
180Stomatitis (HP:0010280)1.50096695
181Hypophosphatemic rickets (HP:0004912)1.49877008
182Disproportionate short-trunk short stature (HP:0003521)1.48464361
183Decreased muscle mass (HP:0003199)1.47782947
184Male pseudohermaphroditism (HP:0000037)1.47492348
185Abnormality of the intrinsic pathway (HP:0010989)1.47218873

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK34.91030085
2MST44.43515027
3LATS13.84338981
4PASK3.23342640
5PNCK3.07616202
6NUAK13.01181738
7BMX2.89430749
8CDK122.79000430
9TEC2.70449738
10MYLK2.67090938
11PTK2B2.52469821
12NTRK32.31635926
13EIF2AK12.28699823
14ACVR1B2.24405376
15EPHA42.24208259
16RIPK42.19257926
17MAP3K42.17035977
18TAOK32.12009926
19BTK2.04444164
20CAMK1G2.00221238
21ZAK1.94333592
22PIK3CG1.91220789
23AKT31.87944069
24CAMK1D1.80559051
25STK31.78454067
26PLK21.77872793
27PDK41.72117308
28PDK31.72117308
29TTK1.64626295
30BLK1.64463114
31MAP4K21.62709217
32BRD41.59153782
33CSF1R1.58660918
34CDK31.57495546
35GRK51.57449620
36MAPK131.56228497
37WNK31.52057239
38TNIK1.46727884
39SYK1.45850783
40WNK11.45352986
41GRK11.42390685
42WNK41.40412589
43INSRR1.37246873
44MAPKAPK31.36789379
45BMPR1B1.32544234
46ADRBK21.32512882
47SRPK11.30597098
48PRKD31.29231056
49BRSK21.28741398
50BMPR21.22046113
51STK381.19358663
52FGR1.19139968
53ILK1.18549884
54TSSK61.17703754
55SGK21.16896859
56STK391.16692750
57ALK1.15991719
58FER1.15223157
59NLK1.08194460
60DAPK21.06026122
61TRIM281.05805674
62SGK4941.05025933
63SGK2231.05025933
64CDC71.03838153
65CDK61.01076676
66NEK61.00923687
67PLK30.99094297
68PRKCI0.98816025
69YES10.92194374
70ATR0.91925110
71PRPF4B0.89865595
72CHEK10.87002545
73GRK60.86871717
74STK240.85960990
75PINK10.85723105
76DMPK0.85687282
77ADRBK10.82426383
78HIPK20.82215368
79PRKCG0.81381579
80SGK30.81161526
81ERBB20.80856107
82PAK30.79722887
83PAK60.77845903
84MAPK100.77580612
85ITK0.77445929
86STK38L0.76552409
87LYN0.75678916
88CAMK2B0.75376592
89PRKAA10.74203812
90EPHA30.73727308
91IRAK10.73691240
92RPS6KB10.73398565
93CSNK1D0.71612641
94PIK3CA0.71546889
95MET0.71284693
96HCK0.70094997
97RET0.69817000
98TRPM70.69049943
99CHEK20.69037658
100NEK20.68761706
101ATM0.68036329
102TNK20.67364748
103BCR0.65388445
104ZAP700.64073659
105NTRK20.63968833
106PKN10.63627089
107DYRK1B0.62758409
108CDK90.62151774
109MARK20.61892723
110OBSCN0.61363654
111GSK3B0.61291249
112PDK20.61052401
113FLT30.60290560
114ERBB30.60144258
115SGK10.59786019
116NEK10.59669189
117RPS6KB20.59644238
118PRKCE0.59271639
119CDK10.58688553
120MUSK0.58547318
121IKBKB0.58537872
122MAPK150.58236746
123MARK10.57923222
124DAPK30.57023678
125PAK10.56988998
126CCNB10.56895320
127MTOR0.56493155
128OXSR10.56157458
129CDK20.55596428
130PTK20.53159315
131MARK30.51684988
132VRK10.50888950
133MAP3K50.50455237
134PRKDC0.50337828
135MAPK80.50081957
136CSNK1E0.49921766
137MAPK140.49374873
138FGFR20.49163516
139PRKG10.48646557
140PRKD10.48586656
141RPS6KA30.48470483
142FGFR10.48141033
143UHMK10.47927663
144RPS6KA20.47255785
145MAPK120.47249193
146FRK0.47184302
147CAMKK20.47006189
148TLK10.46970073
149MAP2K70.46310129
150MAP3K60.45647199
151MINK10.45546141
152CASK0.45029652
153PDGFRB0.44020251
154MAP3K120.43658460
155EPHB20.43304567
156DYRK1A0.43247800
157CDC42BPA0.42473996
158CAMK40.40192168
159PDK10.40078091
160PDPK10.39629070
161CAMK10.39599917
162PRKCZ0.39082780
163PRKAA20.38935704
164MAP2K40.38810630
165PRKACG0.38553135
166IGF1R0.38479932
167FES0.38400357
168PRKCB0.37943309
169MKNK20.37890498
170CAMKK10.37380396
171TESK20.37366883
172PHKG20.36570423
173PHKG10.36570423

Predicted pathways (KEGG)

RankGene SetZ-score
1Platelet activation_Homo sapiens_hsa046114.89554371
2Sulfur metabolism_Homo sapiens_hsa009203.00960999
3Selenocompound metabolism_Homo sapiens_hsa004502.94368538
4Maturity onset diabetes of the young_Homo sapiens_hsa049502.83369262
5Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.71567167
6Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002502.71500908
7SNARE interactions in vesicular transport_Homo sapiens_hsa041302.58595661
8Phototransduction_Homo sapiens_hsa047442.55266706
9Insulin secretion_Homo sapiens_hsa049112.54713177
10Nitrogen metabolism_Homo sapiens_hsa009102.51833745
11One carbon pool by folate_Homo sapiens_hsa006702.43547382
12Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.39930079
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.22030597
14Arachidonic acid metabolism_Homo sapiens_hsa005902.08873257
15Amphetamine addiction_Homo sapiens_hsa050312.06127374
16Other glycan degradation_Homo sapiens_hsa005111.89860469
17ECM-receptor interaction_Homo sapiens_hsa045121.86229427
18Gap junction_Homo sapiens_hsa045401.85067826
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.71510196
20Vitamin B6 metabolism_Homo sapiens_hsa007501.71431936
21Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.63765490
22Glucagon signaling pathway_Homo sapiens_hsa049221.62248700
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.62105574
24mRNA surveillance pathway_Homo sapiens_hsa030151.59568175
25Circadian entrainment_Homo sapiens_hsa047131.54956840
26GABAergic synapse_Homo sapiens_hsa047271.54930978
27Hematopoietic cell lineage_Homo sapiens_hsa046401.53400400
28Taste transduction_Homo sapiens_hsa047421.50926784
29Alcoholism_Homo sapiens_hsa050341.46873389
30Fanconi anemia pathway_Homo sapiens_hsa034601.45726062
31Pyruvate metabolism_Homo sapiens_hsa006201.44498582
32Morphine addiction_Homo sapiens_hsa050321.43439895
33Systemic lupus erythematosus_Homo sapiens_hsa053221.43393787
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.42855829
35Steroid hormone biosynthesis_Homo sapiens_hsa001401.41974091
36ABC transporters_Homo sapiens_hsa020101.41085148
37Olfactory transduction_Homo sapiens_hsa047401.39396445
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.38569877
39Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.37709521
40Long-term depression_Homo sapiens_hsa047301.34719746
41Regulation of autophagy_Homo sapiens_hsa041401.34211098
42Synaptic vesicle cycle_Homo sapiens_hsa047211.31305288
43Nicotine addiction_Homo sapiens_hsa050331.29880722
44Butanoate metabolism_Homo sapiens_hsa006501.27666549
45Phosphatidylinositol signaling system_Homo sapiens_hsa040701.27527685
46Glutamatergic synapse_Homo sapiens_hsa047241.26942010
47Type II diabetes mellitus_Homo sapiens_hsa049301.25078386
48Fatty acid degradation_Homo sapiens_hsa000711.24997482
49* Mismatch repair_Homo sapiens_hsa034301.24069546
50Long-term potentiation_Homo sapiens_hsa047201.23115134
51Lysine degradation_Homo sapiens_hsa003101.20873325
52Dopaminergic synapse_Homo sapiens_hsa047281.19123374
53Collecting duct acid secretion_Homo sapiens_hsa049661.18811350
54Cysteine and methionine metabolism_Homo sapiens_hsa002701.16371815
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.13806427
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.11061683
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.07955044
58Chemokine signaling pathway_Homo sapiens_hsa040621.06740345
59Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.06312360
60Fatty acid elongation_Homo sapiens_hsa000621.05537293
61Glycerophospholipid metabolism_Homo sapiens_hsa005641.03558107
62Fatty acid metabolism_Homo sapiens_hsa012121.02393367
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.01903583
64Propanoate metabolism_Homo sapiens_hsa006401.01222220
65Ether lipid metabolism_Homo sapiens_hsa005651.01117624
66Arginine biosynthesis_Homo sapiens_hsa002201.00298317
67Serotonergic synapse_Homo sapiens_hsa047260.98394567
68Pentose and glucuronate interconversions_Homo sapiens_hsa000400.96361062
69Glycerolipid metabolism_Homo sapiens_hsa005610.96297947
70Cholinergic synapse_Homo sapiens_hsa047250.96181012
71Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.95944330
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.95768034
73Dorso-ventral axis formation_Homo sapiens_hsa043200.91509556
74Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.91134143
75Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.90651332
76Circadian rhythm_Homo sapiens_hsa047100.89642481
77Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.87941666
78Renin secretion_Homo sapiens_hsa049240.87597590
79Aldosterone synthesis and secretion_Homo sapiens_hsa049250.87452177
80Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.84566207
81Primary bile acid biosynthesis_Homo sapiens_hsa001200.83704080
82Oocyte meiosis_Homo sapiens_hsa041140.83177792
83Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.82613238
84Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.81546973
85Sphingolipid metabolism_Homo sapiens_hsa006000.79981531
86Tryptophan metabolism_Homo sapiens_hsa003800.78527771
87Cyanoamino acid metabolism_Homo sapiens_hsa004600.78324971
88Peroxisome_Homo sapiens_hsa041460.78223418
89Salivary secretion_Homo sapiens_hsa049700.77523389
90Chemical carcinogenesis_Homo sapiens_hsa052040.75766562
91Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.75355865
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.75319019
93Insulin resistance_Homo sapiens_hsa049310.74825683
94Gastric acid secretion_Homo sapiens_hsa049710.74739141
95Ovarian steroidogenesis_Homo sapiens_hsa049130.74359137
96Starch and sucrose metabolism_Homo sapiens_hsa005000.74261548
97beta-Alanine metabolism_Homo sapiens_hsa004100.73175934
98Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.73128739
99Cocaine addiction_Homo sapiens_hsa050300.73075126
100RNA transport_Homo sapiens_hsa030130.72114684
101Regulation of actin cytoskeleton_Homo sapiens_hsa048100.71631422
102Dilated cardiomyopathy_Homo sapiens_hsa054140.70584834
103Fat digestion and absorption_Homo sapiens_hsa049750.69507607
104mTOR signaling pathway_Homo sapiens_hsa041500.69144543
105Choline metabolism in cancer_Homo sapiens_hsa052310.67233470
106Calcium signaling pathway_Homo sapiens_hsa040200.66469113
107Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.65997373
108Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.65052690
109Homologous recombination_Homo sapiens_hsa034400.64736603
110Retinol metabolism_Homo sapiens_hsa008300.61973520
111Steroid biosynthesis_Homo sapiens_hsa001000.61791703
112Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.60798402
113Non-homologous end-joining_Homo sapiens_hsa034500.60254278
114Pancreatic secretion_Homo sapiens_hsa049720.59637084
115Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59613935
116Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59364657
117Oxytocin signaling pathway_Homo sapiens_hsa049210.58622018
118alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.58317302
119AMPK signaling pathway_Homo sapiens_hsa041520.57936198
120Ras signaling pathway_Homo sapiens_hsa040140.57729992
121Biosynthesis of amino acids_Homo sapiens_hsa012300.57393970
122Fructose and mannose metabolism_Homo sapiens_hsa000510.57252971
123Vascular smooth muscle contraction_Homo sapiens_hsa042700.55793394
124Vibrio cholerae infection_Homo sapiens_hsa051100.54919975
125Glutathione metabolism_Homo sapiens_hsa004800.54287472
126Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.53901757
127Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53674670
128Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.53582306
129Purine metabolism_Homo sapiens_hsa002300.53461010
130Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.52634023
131Endocytosis_Homo sapiens_hsa041440.51413689
132Inositol phosphate metabolism_Homo sapiens_hsa005620.50343730
133Thyroid hormone synthesis_Homo sapiens_hsa049180.50228172
134Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.50112561
135Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49504507
136Focal adhesion_Homo sapiens_hsa045100.49247240
137cAMP signaling pathway_Homo sapiens_hsa040240.49110337
138Renin-angiotensin system_Homo sapiens_hsa046140.47238473
139cGMP-PKG signaling pathway_Homo sapiens_hsa040220.46950730
140Rap1 signaling pathway_Homo sapiens_hsa040150.44731464
141Linoleic acid metabolism_Homo sapiens_hsa005910.44490073
142Carbon metabolism_Homo sapiens_hsa012000.43257120
143Bile secretion_Homo sapiens_hsa049760.42663786
144Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.41883480
145Type I diabetes mellitus_Homo sapiens_hsa049400.37681096
146Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36579921
147Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36527388
148PPAR signaling pathway_Homo sapiens_hsa033200.34419723
149Fatty acid biosynthesis_Homo sapiens_hsa000610.34003318
150Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.32518028
151Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.31965916
152Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.31794258
153Estrogen signaling pathway_Homo sapiens_hsa049150.31585319
154Complement and coagulation cascades_Homo sapiens_hsa046100.31374940
155FoxO signaling pathway_Homo sapiens_hsa040680.30921075
156Adherens junction_Homo sapiens_hsa045200.30734654
157Melanoma_Homo sapiens_hsa052180.29800806
158Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.29661945
159T cell receptor signaling pathway_Homo sapiens_hsa046600.28860317

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