MLEC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the carbohydrate-binding protein malectin which is a Type I membrane-anchored endoplasmic reticulum protein. This protein has an affinity for Glc2Man9GlcNAc2 (G2M9) N-glycans and is involved in regulating glycosylation in the endoplasmic reticulum. This protein has also been shown to interact with ribophorin I and may be involved in the directing the degradation of misfolded proteins. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)6.53712940
2Golgi transport vesicle coating (GO:0048200)6.53712940
3activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.60537404
4positive regulation of nuclease activity (GO:0032075)4.52009348
5maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.50823731
6positive regulation of histone deacetylation (GO:0031065)4.24864471
7regulation of nuclease activity (GO:0032069)4.09190255
8protein retention in ER lumen (GO:0006621)4.05587006
9endoplasmic reticulum unfolded protein response (GO:0030968)3.93890706
10glucocorticoid receptor signaling pathway (GO:0042921)3.90674007
11mitotic chromosome condensation (GO:0007076)3.74968603
12cellular response to unfolded protein (GO:0034620)3.74882035
13retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.72618956
14paraxial mesoderm development (GO:0048339)3.68884622
154-hydroxyproline metabolic process (GO:0019471)3.62969152
16ER-nucleus signaling pathway (GO:0006984)3.60957932
17COPII vesicle coating (GO:0048208)3.60943542
18protein complex localization (GO:0031503)3.56983659
19pentose-phosphate shunt (GO:0006098)3.56777174
20planar cell polarity pathway involved in neural tube closure (GO:0090179)3.49270781
21regulation of translational fidelity (GO:0006450)3.48092467
22cellular response to topologically incorrect protein (GO:0035967)3.46844364
23peptidyl-lysine dimethylation (GO:0018027)3.44462343
24proline biosynthetic process (GO:0006561)3.44187963
25cellular protein complex localization (GO:0034629)3.35040725
26tricarboxylic acid metabolic process (GO:0072350)3.32618883
27focal adhesion assembly (GO:0048041)3.32196379
28cell-substrate adherens junction assembly (GO:0007045)3.32196379
29negative regulation of fatty acid transport (GO:2000192)3.29009582
30valine metabolic process (GO:0006573)3.27525160
31maternal placenta development (GO:0001893)3.24014765
32negative regulation of cell size (GO:0045792)3.22455048
33exocrine pancreas development (GO:0031017)3.19950073
34vesicle coating (GO:0006901)3.18861545
35folic acid-containing compound biosynthetic process (GO:0009396)3.18298786
36NADPH regeneration (GO:0006740)3.16821135
37regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.16576316
38corticosteroid receptor signaling pathway (GO:0031958)3.15569778
39insulin-like growth factor receptor signaling pathway (GO:0048009)3.13100517
40desmosome organization (GO:0002934)3.09252917
41response to endoplasmic reticulum stress (GO:0034976)3.05342742
42pore complex assembly (GO:0046931)3.04858826
43positive regulation of protein deacetylation (GO:0090312)3.04518182
44antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.04385053
45antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.04385053
46bundle of His cell to Purkinje myocyte communication (GO:0086069)3.00400745
47cellular response to vitamin D (GO:0071305)2.98162666
48NADH metabolic process (GO:0006734)2.94343593
49apoptotic cell clearance (GO:0043277)2.92043334
50heterochromatin organization (GO:0070828)2.90870209
51sequestering of metal ion (GO:0051238)2.89349999
52cellular response to vitamin (GO:0071295)2.87209415
53nuclear pore complex assembly (GO:0051292)2.84461171
54lysine catabolic process (GO:0006554)2.83509950
55lysine metabolic process (GO:0006553)2.83509950
56mRNA stabilization (GO:0048255)2.82989742
57RNA stabilization (GO:0043489)2.82989742
58growth hormone receptor signaling pathway (GO:0060396)2.81735206
59response to unfolded protein (GO:0006986)2.80514409
60notochord development (GO:0030903)2.79930054
61regulation of fatty acid beta-oxidation (GO:0031998)2.78342700
62gap junction assembly (GO:0016264)2.77736925
63urea cycle (GO:0000050)2.77008504
64basement membrane organization (GO:0071711)2.76797454
65peptidyl-proline hydroxylation (GO:0019511)2.75727674
66embryonic process involved in female pregnancy (GO:0060136)2.74179118
67barbed-end actin filament capping (GO:0051016)2.73650033
68protein hydroxylation (GO:0018126)2.73063343
69DNA unwinding involved in DNA replication (GO:0006268)2.70534685
70branching involved in mammary gland duct morphogenesis (GO:0060444)2.69632147
71peptide catabolic process (GO:0043171)2.68622684
72hemidesmosome assembly (GO:0031581)2.67552045
73drug transmembrane transport (GO:0006855)2.62813527
74response to topologically incorrect protein (GO:0035966)2.62576117
75establishment of apical/basal cell polarity (GO:0035089)2.61722925
76positive regulation of SMAD protein import into nucleus (GO:0060391)2.61364788
77cytoplasmic mRNA processing body assembly (GO:0033962)2.60997302
78epithelial cell-cell adhesion (GO:0090136)2.60850479
79L-alpha-amino acid transmembrane transport (GO:1902475)2.60363789
80nuclear pore organization (GO:0006999)2.60211937
81regulation of early endosome to late endosome transport (GO:2000641)2.60191873
82glucose catabolic process (GO:0006007)2.59820453
83activation of Rac GTPase activity (GO:0032863)2.59448492
84mannose metabolic process (GO:0006013)2.59147163
85regulation of mammary gland epithelial cell proliferation (GO:0033599)2.58918212
86urea metabolic process (GO:0019627)2.57750160
87positive regulation of hormone biosynthetic process (GO:0046886)2.54556924
88establishment of integrated proviral latency (GO:0075713)2.53997320
89regulation of RNA export from nucleus (GO:0046831)2.52646755
90type B pancreatic cell development (GO:0003323)2.52426395
91germ cell migration (GO:0008354)2.51007655
92regulation of cholesterol homeostasis (GO:2000188)2.50571059
93protein localization to endosome (GO:0036010)2.49935965
94UDP-N-acetylglucosamine metabolic process (GO:0006047)2.49200191
95antigen processing and presentation via MHC class Ib (GO:0002475)2.49120816
96endothelial cell morphogenesis (GO:0001886)2.48380790
97protein maturation by protein folding (GO:0022417)2.47836904
98cell adhesion mediated by integrin (GO:0033627)2.46787608
99protein export from nucleus (GO:0006611)2.46013980
100NLS-bearing protein import into nucleus (GO:0006607)2.45869836
101ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.45746755
102cellular response to growth hormone stimulus (GO:0071378)2.45708788
103epithelial cell differentiation involved in prostate gland development (GO:0060742)2.45485086
104hippo signaling (GO:0035329)2.44624506
105regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.44612135
106convergent extension (GO:0060026)2.44071277
107regulation of glucose import in response to insulin stimulus (GO:2001273)2.41958502
108cytoskeletal anchoring at plasma membrane (GO:0007016)2.41576429
109antigen processing and presentation of endogenous antigen (GO:0019883)2.41359050
110nucleotide-sugar biosynthetic process (GO:0009226)2.41227290
111positive regulation of glycogen biosynthetic process (GO:0045725)2.38013786
112response to epidermal growth factor (GO:0070849)2.37548531
113pinocytosis (GO:0006907)2.37248382
114negative regulation of cell fate specification (GO:0009996)2.35841285
115regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.35806895
116dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.35170206
117proline metabolic process (GO:0006560)2.35115441
118* peptidyl-asparagine modification (GO:0018196)2.34963587
119Golgi organization (GO:0007030)2.34962859
120regulation of hippo signaling (GO:0035330)2.34845258
121glutamine family amino acid biosynthetic process (GO:0009084)2.34830387
122mitotic sister chromatid cohesion (GO:0007064)2.34230884
123cell-substrate junction assembly (GO:0007044)2.33338897
124positive regulation of blood vessel endothelial cell migration (GO:0043536)2.33257770
125adherens junction assembly (GO:0034333)2.32995608
126semaphorin-plexin signaling pathway (GO:0071526)2.32857025
127midgut development (GO:0007494)2.32664353
128mitotic G1 DNA damage checkpoint (GO:0031571)2.32362653
129polarized epithelial cell differentiation (GO:0030859)2.31562225
130* protein N-linked glycosylation via asparagine (GO:0018279)2.30749674
131regulation of SMAD protein import into nucleus (GO:0060390)2.29850611
132establishment or maintenance of apical/basal cell polarity (GO:0035088)2.29525403
133establishment or maintenance of bipolar cell polarity (GO:0061245)2.29525403
134DNA duplex unwinding (GO:0032508)2.29109730
135protein localization to microtubule (GO:0035372)2.28766384
136chromosome condensation (GO:0030261)2.28749499
137trophectodermal cell differentiation (GO:0001829)2.28463997
138regulation of translational termination (GO:0006449)2.28438529
139membrane protein ectodomain proteolysis (GO:0006509)2.28347279
140Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.28232842
141regulation of polysaccharide biosynthetic process (GO:0032885)2.28215468
142establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.28130814
143glucose 6-phosphate metabolic process (GO:0051156)2.26448517
144receptor catabolic process (GO:0032801)2.25692270
145skin morphogenesis (GO:0043589)2.25165018
146regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.24639779
147embryonic eye morphogenesis (GO:0048048)2.24599413
148regulation of nucleobase-containing compound transport (GO:0032239)2.24259251
149protein localization to chromosome, centromeric region (GO:0071459)2.23795029
150apoptotic process involved in morphogenesis (GO:0060561)2.23263246
151pre-miRNA processing (GO:0031054)2.23022786
152cellular response to epidermal growth factor stimulus (GO:0071364)2.21309014
153cortical actin cytoskeleton organization (GO:0030866)2.20502747
154cellular response to lithium ion (GO:0071285)2.20129243

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.55091494
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.04431232
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.55806773
4MYC_22102868_ChIP-Seq_BL_Human3.13881104
5FOXM1_23109430_ChIP-Seq_U2OS_Human2.98306988
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.62300885
7CLOCK_20551151_ChIP-Seq_293T_Human2.50690012
8TP63_17297297_ChIP-ChIP_HaCaT_Human2.45060053
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.38346413
10VDR_21846776_ChIP-Seq_THP-1_Human2.34670614
11STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.27465440
12* TCF7_22412390_ChIP-Seq_EML_Mouse2.06805662
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.03590501
14ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.01801277
15MYC_18555785_ChIP-Seq_MESCs_Mouse1.97861462
16ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.96842617
17POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.94047349
18TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.92234272
19KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.92233416
20KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.86992838
21KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.85225493
22ELK3_25401928_ChIP-Seq_HUVEC_Human1.80031530
23KDM2B_26808549_Chip-Seq_DND41_Human1.75294916
24AR_21909140_ChIP-Seq_LNCAP_Human1.74744992
25TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.74079198
26PPARA_22158963_ChIP-Seq_LIVER_Mouse1.72214811
27RARG_19884340_ChIP-ChIP_MEFs_Mouse1.70919720
28SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.68595861
29TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65825303
30STAT6_21828071_ChIP-Seq_BEAS2B_Human1.65406107
31MYC_19079543_ChIP-ChIP_MESCs_Mouse1.63779647
32BRD4_27068464_Chip-Seq_AML-cells_Mouse1.60476400
33* UTX_26944678_Chip-Seq_JUKART_Human1.59253151
34MYB_21317192_ChIP-Seq_ERMYB_Mouse1.59020756
35RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.58373032
36MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.57096241
37P300_27058665_Chip-Seq_ZR-75-30cells_Human1.55792884
38TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.55553478
39GATA1_22025678_ChIP-Seq_K562_Human1.55449382
40RXR_22158963_ChIP-Seq_LIVER_Mouse1.54850876
41STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.53215539
42KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.52638727
43NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.52466410
44RACK7_27058665_Chip-Seq_MCF-7_Human1.50449681
45NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.50307981
46* MAF_26560356_Chip-Seq_TH1_Human1.50060138
47KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.49485390
48VDR_24763502_ChIP-Seq_THP-1_Human1.48190171
49KDM2B_26808549_Chip-Seq_SUP-B15_Human1.44780864
50ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.43897152
51* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.43492475
52ATF3_27146783_Chip-Seq_COLON_Human1.42666556
53SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.42438151
54PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.41710752
55SOX2_27498859_Chip-Seq_STOMACH_Mouse1.41179385
56LXR_22292898_ChIP-Seq_THP-1_Human1.39548193
57ZNF263_19887448_ChIP-Seq_K562_Human1.39523747
58FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.39512078
59TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.36630537
60* GATA6_25053715_ChIP-Seq_YYC3_Human1.36536842
61CHD1_26751641_Chip-Seq_LNCaP_Human1.35468237
62NCOR1_26117541_ChIP-Seq_K562_Human1.34016708
63MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.31457014
64TCF3_18692474_ChIP-Seq_MEFs_Mouse1.31209052
65LXR_22158963_ChIP-Seq_LIVER_Mouse1.29462913
66SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.28831474
67CIITA_25753668_ChIP-Seq_RAJI_Human1.28099795
68NELFA_20434984_ChIP-Seq_ESCs_Mouse1.28035303
69KDM2B_26808549_Chip-Seq_K562_Human1.27251368
70HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.27206371
71HIF1A_21447827_ChIP-Seq_MCF-7_Human1.26895693
72SCL_19346495_ChIP-Seq_HPC-7_Human1.24856121
73E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.24418230
74DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.24291083
75FOXO3_23340844_ChIP-Seq_DLD1_Human1.24180629
76* MYB_26560356_Chip-Seq_TH2_Human1.23622956
77CDX2_20551321_ChIP-Seq_CACO-2_Human1.23389918
78NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.23359231
79MYB_26560356_Chip-Seq_TH1_Human1.22547371
80* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21972754
81* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.21197571
82CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.21107976
83* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.21012545
84TRIM28_21343339_ChIP-Seq_HEK293_Human1.20874703
85MYC_19030024_ChIP-ChIP_MESCs_Mouse1.19909308
86THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.19351770
87TFEB_21752829_ChIP-Seq_HELA_Human1.18470969
88E2F1_21310950_ChIP-Seq_MCF-7_Human1.17015925
89ESR1_15608294_ChIP-ChIP_MCF-7_Human1.16464707
90* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.16461359
91HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.16415910
92SOX9_24532713_ChIP-Seq_HFSC_Mouse1.15985608
93EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.15791972
94UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.15734716
95* RUNX1_22412390_ChIP-Seq_EML_Mouse1.15708130
96* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.15522841
97ESR1_21235772_ChIP-Seq_MCF-7_Human1.14446674
98FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.13903784
99KDM2B_26808549_Chip-Seq_JURKAT_Human1.13110866
100MYCN_18555785_ChIP-Seq_MESCs_Mouse1.12032728
101TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11655121
102WT1_19549856_ChIP-ChIP_CCG9911_Human1.10688549
103* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.10479145
104CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.10339889
105ZFX_18555785_ChIP-Seq_MESCs_Mouse1.09845864
106SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.08767797
107NANOG_21062744_ChIP-ChIP_HESCs_Human1.08101138
108NANOG_18555785_ChIP-Seq_MESCs_Mouse1.07891350
109SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.07727677
110SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.07727677
111KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06627918
112SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.06570316
113ZFP281_18757296_ChIP-ChIP_E14_Mouse1.06012757
114TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.05669862
115RUNX1_27514584_Chip-Seq_MCF-7_Human1.05125420
116SPI1_23127762_ChIP-Seq_K562_Human1.05104683
117WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.05017579
118CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.04761936
119KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.04299303
120TP53_22127205_ChIP-Seq_IMR90_Human1.04149201
121ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.03871931
122E2F4_17652178_ChIP-ChIP_JURKAT_Human1.03524710
123STAT3_1855785_ChIP-Seq_MESCs_Mouse1.03514574
124TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.02406748
125FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.00957002
126UBF1/2_26484160_Chip-Seq_HMECs_Human1.00090070
127NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.99520553
128CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.99504569
129OCT4_18692474_ChIP-Seq_MEFs_Mouse0.99212311
130ESR2_21235772_ChIP-Seq_MCF-7_Human0.98902957
131CREB1_26743006_Chip-Seq_LNCaP_Human0.98604531
132TBX20_22328084_ChIP-Seq_HEART_Mouse0.98563195
133TBX20_22080862_ChIP-Seq_HEART_Mouse0.98563195
134KDM5A_27292631_Chip-Seq_BREAST_Human0.98327973
135* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.97084509
136PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.96229301
137* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.95454685

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.63840789
2MP0003300_gastrointestinal_ulcer3.33502694
3MP0010352_gastrointestinal_tract_polyps2.96527211
4MP0008438_abnormal_cutaneous_collagen2.89920569
5MP0002877_abnormal_melanocyte_morpholog2.75122257
6MP0006054_spinal_hemorrhage2.67078032
7MP0010234_abnormal_vibrissa_follicle2.50845796
8MP0003941_abnormal_skin_development2.46827394
9MP0003566_abnormal_cell_adhesion2.34910361
10MP0005076_abnormal_cell_differentiation2.31104399
11MP0005409_darkened_coat_color2.24597721
12MP0005257_abnormal_intraocular_pressure2.24455829
13MP0004264_abnormal_extraembryonic_tissu2.17414842
14MP0005451_abnormal_body_composition2.02489944
15MP0004858_abnormal_nervous_system1.93871977
16MP0003283_abnormal_digestive_organ1.86752263
17MP0002796_impaired_skin_barrier1.65399082
18MP0004185_abnormal_adipocyte_glucose1.63870637
19MP0010307_abnormal_tumor_latency1.58931998
20MP0003252_abnormal_bile_duct1.58644533
21MP0003693_abnormal_embryo_hatching1.58008021
22MP0008961_abnormal_basal_metabolism1.57169037
23MP0003111_abnormal_nucleus_morphology1.54611241
24MP0005275_abnormal_skin_tensile1.49793382
25MP0005360_urolithiasis1.48366331
26MP0005220_abnormal_exocrine_pancreas1.46094871
27MP0004272_abnormal_basement_membrane1.46011985
28MP0002396_abnormal_hematopoietic_system1.44897931
29MP0005666_abnormal_adipose_tissue1.42868899
30MP0001849_ear_inflammation1.42139855
31MP0001958_emphysema1.41470762
32MP0004808_abnormal_hematopoietic_stem1.41159318
33MP0002896_abnormal_bone_mineralization1.39785432
34MP0000537_abnormal_urethra_morphology1.36694733
35MP0009278_abnormal_bone_marrow1.33165960
36MP0003453_abnormal_keratinocyte_physiol1.33101976
37MP0009780_abnormal_chondrocyte_physiolo1.30869498
38MP0009643_abnormal_urine_homeostasis1.30312560
39MP0005375_adipose_tissue_phenotype1.29205371
40MP0000003_abnormal_adipose_tissue1.29037786
41MP0005058_abnormal_lysosome_morphology1.28128520
42MP0005023_abnormal_wound_healing1.28071085
43MP0004782_abnormal_surfactant_physiolog1.25565167
44MP0003045_fibrosis1.24769064
45MP0000733_abnormal_muscle_development1.23704550
46MP0000462_abnormal_digestive_system1.23696780
47MP0003315_abnormal_perineum_morphology1.22476433
48MP0010030_abnormal_orbit_morphology1.22456300
49MP0005501_abnormal_skin_physiology1.22203480
50MP0003303_peritoneal_inflammation1.20679275
51MP0008932_abnormal_embryonic_tissue1.19213751
52MP0000762_abnormal_tongue_morphology1.18576801
53MP0000566_synostosis1.18347467
54MP0001666_abnormal_nutrient_absorption1.17574712
55MP0004043_abnormal_pH_regulation1.16293772
56MP0003868_abnormal_feces_composition1.15583336
57MP0000751_myopathy1.15538976
58MP0002139_abnormal_hepatobiliary_system1.15413932
59MP0004197_abnormal_fetal_growth/weight/1.14372884
60MP0010368_abnormal_lymphatic_system1.13746699
61MP0001661_extended_life_span1.13115339
62MP0009384_cardiac_valve_regurgitation1.13097296
63MP0001944_abnormal_pancreas_morphology1.12913743
64MP0003172_abnormal_lysosome_physiology1.12575103
65MP0002009_preneoplasia1.11292493
66MP0003077_abnormal_cell_cycle1.09500738
67MP0005623_abnormal_meninges_morphology1.07816493
68MP0001730_embryonic_growth_arrest1.06688466
69MP0009053_abnormal_anal_canal1.06274384
70MP0002086_abnormal_extraembryonic_tissu1.05331142
71MP0002697_abnormal_eye_size1.04400754
72MP0009672_abnormal_birth_weight1.04160018
73MP0000534_abnormal_ureter_morphology1.04073877
74MP0003385_abnormal_body_wall1.03454253
75MP0000013_abnormal_adipose_tissue1.02827556
76MP0002928_abnormal_bile_duct1.01430301
77MP0003279_aneurysm1.01166955
78MP0001765_abnormal_ion_homeostasis1.00900146
79MP0000490_abnormal_crypts_of1.00851571
80MP0002166_altered_tumor_susceptibility1.00666395
81MP0000428_abnormal_craniofacial_morphol0.98482528
82MP0003091_abnormal_cell_migration0.98388233
83MP0005365_abnormal_bile_salt0.97221048
84MP0003984_embryonic_growth_retardation0.96981976
85MP0002088_abnormal_embryonic_growth/wei0.96180666
86MP0003123_paternal_imprinting0.95343134
87MP0009703_decreased_birth_body0.94761335
88MP0001915_intracranial_hemorrhage0.94562216
89MP0008057_abnormal_DNA_replication0.93711471
90MP0006138_congestive_heart_failure0.93296804
91MP0000627_abnormal_mammary_gland0.92570482
92MP0004087_abnormal_muscle_fiber0.92338038
93MP0002084_abnormal_developmental_patter0.89274414
94MP0001299_abnormal_eye_distance/0.88937493
95MP0000467_abnormal_esophagus_morphology0.88675002
96MP0000432_abnormal_head_morphology0.88542981
97MP0002060_abnormal_skin_morphology0.88203416
98MP0005621_abnormal_cell_physiology0.88168772
99MP0002089_abnormal_postnatal_growth/wei0.87336552
100MP0005670_abnormal_white_adipose0.86377433
101MP0005380_embryogenesis_phenotype0.85811286
102MP0001672_abnormal_embryogenesis/_devel0.85811286
103MP0004233_abnormal_muscle_weight0.85599919
104MP0009379_abnormal_foot_pigmentation0.83916507
105MP0010094_abnormal_chromosome_stability0.83828020
106MP0001756_abnormal_urination0.83813779
107MP0001697_abnormal_embryo_size0.83131329
108MP0005503_abnormal_tendon_morphology0.82384239
109MP0004130_abnormal_muscle_cell0.81407465
110MP0000350_abnormal_cell_proliferation0.81341415
111MP0003115_abnormal_respiratory_system0.81285886
112MP0000477_abnormal_intestine_morphology0.81256497
113MP0004957_abnormal_blastocyst_morpholog0.80415359
114MP0002080_prenatal_lethality0.80385462
115MP0002168_other_aberrant_phenotype0.79993352
116MP0003942_abnormal_urinary_system0.79851700
117MP0005083_abnormal_biliary_tract0.79690322
118MP0005408_hypopigmentation0.79401327
119MP0002098_abnormal_vibrissa_morphology0.79263326
120MP0000598_abnormal_liver_morphology0.78932619
121MP0005330_cardiomyopathy0.78869598
122MP0000858_altered_metastatic_potential0.78491079
123MP0003191_abnormal_cellular_cholesterol0.78279903
124MP0000609_abnormal_liver_physiology0.78012906
125MP0002136_abnormal_kidney_physiology0.77923115
126MP0002092_abnormal_eye_morphology0.77508518
127MP0001881_abnormal_mammary_gland0.76888626
128MP0003959_abnormal_lean_body0.76497570
129MP0003795_abnormal_bone_structure0.76277058
130MP0010678_abnormal_skin_adnexa0.76082205
131MP0002909_abnormal_adrenal_gland0.74689758
132MP0010630_abnormal_cardiac_muscle0.74687543
133MP0004947_skin_inflammation0.73886118
134MP0002925_abnormal_cardiovascular_devel0.72854045
135MP0002085_abnormal_embryonic_tissue0.71988424
136MP0002693_abnormal_pancreas_physiology0.70575769
137MP0010155_abnormal_intestine_physiology0.70508425
138MP0002970_abnormal_white_adipose0.70308300
139MP0003221_abnormal_cardiomyocyte_apopto0.70229877
140MP0000747_muscle_weakness0.69556066
141MP0009840_abnormal_foam_cell0.68950528
142MP0000678_abnormal_parathyroid_gland0.68671471
143MP0002135_abnormal_kidney_morphology0.68298970

Predicted human phenotypes

RankGene SetZ-score
1Cerebral aneurysm (HP:0004944)3.71749973
2Protrusio acetabuli (HP:0003179)3.55165481
3Cervical subluxation (HP:0003308)3.00211695
4Hyperacusis (HP:0010780)2.95164184
5Thin bony cortex (HP:0002753)2.88991568
6Premature rupture of membranes (HP:0001788)2.84385577
7Right ventricular cardiomyopathy (HP:0011663)2.69708073
8Ankle contracture (HP:0006466)2.68171060
9Shallow orbits (HP:0000586)2.66575177
10Aortic aneurysm (HP:0004942)2.66451404
11Hand muscle atrophy (HP:0009130)2.56339035
12Centrally nucleated skeletal muscle fibers (HP:0003687)2.55539147
13Vertebral compression fractures (HP:0002953)2.46624623
14Rectal prolapse (HP:0002035)2.46206172
15Arterial tortuosity (HP:0005116)2.45818392
16Lymphangioma (HP:0100764)2.45773141
17Aneurysm (HP:0002617)2.45474546
18Mitral valve prolapse (HP:0001634)2.44181116
19Bowel diverticulosis (HP:0005222)2.40180538
20Bladder diverticulum (HP:0000015)2.37081683
21Elfin facies (HP:0004428)2.35656013
22Subacute progressive viral hepatitis (HP:0006572)2.34305756
23Distal upper limb amyotrophy (HP:0007149)2.32687572
24Upper limb amyotrophy (HP:0009129)2.32687572
25Abnormality of the distal phalanx of the thumb (HP:0009617)2.31708538
26Vascular tortuosity (HP:0004948)2.30307032
27Mucopolysacchariduria (HP:0008155)2.29839388
28Urinary glycosaminoglycan excretion (HP:0003541)2.29839388
29Severe short stature (HP:0003510)2.29172828
30Macroorchidism (HP:0000053)2.27038545
31Aortic dissection (HP:0002647)2.27032766
32Dilatation of the ascending aorta (HP:0005111)2.23311809
33Spinal rigidity (HP:0003306)2.21771320
34Achilles tendon contracture (HP:0001771)2.20677166
35Distal lower limb amyotrophy (HP:0008944)2.20279030
36Renal duplication (HP:0000075)2.19973418
37Back pain (HP:0003418)2.18026321
38Wormian bones (HP:0002645)2.16954329
39Metaphyseal cupping (HP:0003021)2.16264149
40Enlarged penis (HP:0000040)2.13096666
41Increased density of long bones (HP:0006392)2.11727829
42Genu recurvatum (HP:0002816)2.10183712
43Abnormality of carpal bone ossification (HP:0006257)2.08775703
44Abnormality of the Achilles tendon (HP:0005109)2.08218458
45Atrophic scars (HP:0001075)2.07208490
46Ulnar bowing (HP:0003031)2.06755253
47Hypoglycemic coma (HP:0001325)2.06236687
48Abnormal ossification of hand bones (HP:0005921)2.04271776
49Hallux valgus (HP:0001822)2.03658325
50Deviation of the hallux (HP:0010051)2.02205802
51Neonatal short-limb short stature (HP:0008921)2.01939277
52Broad face (HP:0000283)2.00890655
53Renovascular hypertension (HP:0100817)2.00413388
54Advanced eruption of teeth (HP:0006288)1.99756835
55Termporal pattern (HP:0011008)1.98812466
56Insidious onset (HP:0003587)1.98812466
57Abnormality of mucopolysaccharide metabolism (HP:0011020)1.98140340
58Abnormality of polysaccharide metabolism (HP:0011012)1.98140340
59Abnormality of glycosaminoglycan metabolism (HP:0004371)1.98140340
60Ulnar deviation of the wrist (HP:0003049)1.98109794
61Short nail (HP:0001799)1.96714581
62Thoracolumbar scoliosis (HP:0002944)1.96469370
63Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.94961409
64Abnormality of the fingertips (HP:0001211)1.93696758
65Gout (HP:0001997)1.93443095
66Exostoses (HP:0100777)1.92969859
67Distal lower limb muscle weakness (HP:0009053)1.92518202
68Breech presentation (HP:0001623)1.91510387
69Hypercalciuria (HP:0002150)1.91445357
70Osteolytic defects of the phalanges of the hand (HP:0009771)1.91070638
71Osteolytic defects of the hand bones (HP:0009699)1.91070638
72Ketoacidosis (HP:0001993)1.88479304
73Flat acetabular roof (HP:0003180)1.88181273
74Peritonitis (HP:0002586)1.86467804
75Abnormality of the calcaneus (HP:0008364)1.86206960
76Selective tooth agenesis (HP:0001592)1.85789211
77Increased variability in muscle fiber diameter (HP:0003557)1.84956037
78Deviation of the thumb (HP:0009603)1.84945953
79Deep venous thrombosis (HP:0002625)1.83589637
80Thrombocytosis (HP:0001894)1.83476730
81Spastic diplegia (HP:0001264)1.83253350
82Dysostosis multiplex (HP:0000943)1.83201240
83Abnormality of skeletal muscle fiber size (HP:0012084)1.81857332
84Hematochezia (HP:0002573)1.81592037
85Arnold-Chiari malformation (HP:0002308)1.80755882
86Abnormality of oral frenula (HP:0000190)1.80304144
87Spinal cord compression (HP:0002176)1.80129025
88Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.79512508
89Short 4th metacarpal (HP:0010044)1.79512508
90Spinal cord lesions (HP:0100561)1.79282622
91Syringomyelia (HP:0003396)1.79282622
92Turricephaly (HP:0000262)1.79030655
93Vertebral arch anomaly (HP:0008438)1.78723136
94Ankyloglossia (HP:0010296)1.78537379
95Late onset (HP:0003584)1.78224666
96Abnormality of the pancreatic islet cells (HP:0006476)1.77843888
97Abnormality of endocrine pancreas physiology (HP:0012093)1.77843888
98Abnormality of monocarboxylic acid metabolism (HP:0010996)1.77794460
99Blue sclerae (HP:0000592)1.77322797
100Radial bowing (HP:0002986)1.76376542
101Abnormality of the thoracic spine (HP:0100711)1.76039937
102Dysmetric saccades (HP:0000641)1.75912365
103Trismus (HP:0000211)1.75704783
104Abnormality of dentin (HP:0010299)1.73725240
105Buphthalmos (HP:0000557)1.73206600
106Broad metatarsal (HP:0001783)1.72229661
107Elbow flexion contracture (HP:0002987)1.71607886
108Midface retrusion (HP:0011800)1.71080771
109Disproportionate tall stature (HP:0001519)1.69446831
110Abnormality of complement system (HP:0005339)1.69257741
111Abnormal foot bone ossification (HP:0010675)1.69160236
112Abnormal delivery (HP:0001787)1.68913258
113Abnormality of chloride homeostasis (HP:0011422)1.68263693
114Abdominal distention (HP:0003270)1.68230342
115Long toe (HP:0010511)1.68097647
116Hemorrhage of the eye (HP:0011885)1.68060196
117Patellar dislocation (HP:0002999)1.67510608
118Abnormality of the gastric mucosa (HP:0004295)1.67019208
119Increased connective tissue (HP:0009025)1.66860246
120Mildly elevated creatine phosphokinase (HP:0008180)1.66080598
121Abnormality of the acetabulum (HP:0003170)1.65945280
122High pitched voice (HP:0001620)1.65044100
123Abnormal tarsal ossification (HP:0008369)1.64682153
124Persistence of primary teeth (HP:0006335)1.64061765
125Natal tooth (HP:0000695)1.63261900
126Lower limb amyotrophy (HP:0007210)1.62992373
127Relative macrocephaly (HP:0004482)1.62835600
128Abnormality of purine metabolism (HP:0004352)1.62762989
129Resting tremor (HP:0002322)1.62555421
130Insulin resistance (HP:0000855)1.62418116
131Hyperinsulinemic hypoglycemia (HP:0000825)1.62103015
132Coronal craniosynostosis (HP:0004440)1.61488280
133Hyperextensible skin (HP:0000974)1.61417467
134Bowed forearm bones (HP:0003956)1.60832993
135Bowing of the arm (HP:0006488)1.60832993
136Overriding aorta (HP:0002623)1.60618797
137Bronchomalacia (HP:0002780)1.59826527
138Impaired platelet aggregation (HP:0003540)1.59679562
139Abnormal platelet function (HP:0011869)1.59679562
140Long palpebral fissure (HP:0000637)1.59557428
141Missing ribs (HP:0000921)1.59094203
142Choanal stenosis (HP:0000452)1.59075185
143Asymmetry of the thorax (HP:0001555)1.59073319
144Fragile skin (HP:0001030)1.59050007
145Increased nuchal translucency (HP:0010880)1.58492988
146Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.56924452
147Increased mean platelet volume (HP:0011877)1.56906855
148Abnormal cartilage morphology (HP:0002763)1.56798360
149Abnormality of the distal phalanges of the toes (HP:0010182)1.56460170
150Congenital glaucoma (HP:0001087)1.55725118
151Spondylolisthesis (HP:0003302)1.55535221
152Cutaneous melanoma (HP:0012056)1.54124649
153Tibial bowing (HP:0002982)1.53967051
154Abnormality of the 4th metacarpal (HP:0010012)1.53373581
155Pseudobulbar signs (HP:0002200)1.53282579
156Insomnia (HP:0100785)1.52905111

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.00173590
2PKN24.10711498
3EEF2K4.03610030
4SMG13.35075954
5ERN13.03622623
6MST1R2.93021832
7MAP3K102.81092223
8LATS22.63903876
9PTK62.46214915
10SCYL22.23929305
11CDK122.13266930
12PDGFRA2.13153393
13RIPK12.11056566
14FLT32.05769133
15LRRK22.02720081
16TAOK32.00699909
17SIK11.99304741
18TTN1.92886175
19STK101.81734067
20LATS11.76535990
21PASK1.73562689
22PRPF4B1.55349326
23PAK41.51315993
24FRK1.39012146
25IRAK31.33241348
26MTOR1.25684864
27NME21.23561459
28CAMK1D1.22848109
29RPS6KB21.20061487
30PAK21.18092896
31EPHB11.17927862
32STK31.16328270
33CDK61.15485887
34WNK41.11237463
35NEK21.07702492
36ERBB41.06808729
37PBK1.06388487
38ALK1.06004376
39PTK21.05285990
40MAP3K81.04284096
41TSSK61.03091841
42FGFR41.03086502
43CAMK1G1.01656740
44DDR21.00666870
45MAP4K10.95391678
46BMX0.93876221
47MAP2K30.93028071
48PDGFRB0.91554842
49RET0.88681890
50KSR20.88366801
51ZAP700.86762452
52TGFBR20.86202068
53CDK40.86125085
54BCKDK0.85701895
55FGFR30.84733555
56TESK10.84292815
57HIPK20.82999320
58ICK0.80476442
59EPHB20.79732949
60BRSK20.79672835
61RPS6KA40.79662835
62CDC70.79192178
63SRPK10.78398446
64MAPKAPK30.78085943
65DMPK0.77782585
66PRKG20.77068079
67NEK10.73794169
68BTK0.72721713
69MAP3K20.72716108
70MELK0.72180426
71TGFBR10.71752208
72NEK90.69093306
73MET0.68807822
74JAK30.68386061
75TAF10.66044916
76PRKD30.64915231
77MAP3K70.64186807
78GRK60.63890817
79EIF2AK10.63727564
80FGFR10.62468519
81CDC42BPA0.61076533
82AKT30.60078499
83STK240.58865583
84EPHA20.58257615
85STK38L0.58237702
86MYLK0.58036767
87ITK0.57895635
88DYRK1B0.57823869
89JAK10.57340415
90JAK20.56638521
91ILK0.55840737
92ARAF0.55143276
93MAP3K90.54763641
94CSF1R0.54245752
95EPHA30.53484648
96PRKCH0.52786067
97LMTK20.52371983
98TRPM70.51330390
99INSRR0.50347941
100MAPK110.49718523
101AURKB0.49057220
102AKT20.48627781
103WEE10.48558280
104PDK30.47994546
105PDK40.47994546
106CHEK10.47505987
107WNK10.47245131
108BRD40.45957603
109TAOK10.45612952
110GSK3A0.44728001
111CHEK20.43242044
112TYK20.42019035
113RPS6KA20.41845287
114TTK0.40278154
115PIM10.40260050
116MAP3K130.40159635
117CLK10.39506777
118PNCK0.39401357
119CDK80.39184195
120FGFR20.39147257
121PDPK10.38693682
122MAP2K20.38526592
123ROCK20.38142940
124BRAF0.36475380
125MAP3K30.36227861
126WNK30.35948102
127STK390.34983876
128STK40.34765219
129MOS0.34689104
130NTRK10.34079544
131YES10.33602810
132CDK90.33433399
133FER0.33345313
134ATR0.32530984
135PRKD10.31503140
136MAP3K10.30480597
137EGFR0.29972967
138CDK70.29951983
139CDK10.28825388
140KSR10.28815202
141RPS6KB10.28106536
142STK380.26272802

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.56986579
2Maturity onset diabetes of the young_Homo sapiens_hsa049502.28560445
3Lysine degradation_Homo sapiens_hsa003101.94242081
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.83903687
5Chronic myeloid leukemia_Homo sapiens_hsa052201.82258693
6Protein digestion and absorption_Homo sapiens_hsa049741.76010501
7Selenocompound metabolism_Homo sapiens_hsa004501.70085612
8Arginine biosynthesis_Homo sapiens_hsa002201.67702823
9Fructose and mannose metabolism_Homo sapiens_hsa000511.65754348
10N-Glycan biosynthesis_Homo sapiens_hsa005101.58180273
11Nitrogen metabolism_Homo sapiens_hsa009101.48784415
12DNA replication_Homo sapiens_hsa030301.48473798
13Small cell lung cancer_Homo sapiens_hsa052221.45696489
14Focal adhesion_Homo sapiens_hsa045101.45234167
15Carbohydrate digestion and absorption_Homo sapiens_hsa049731.44097337
16Insulin resistance_Homo sapiens_hsa049311.40850577
17Glycosaminoglycan degradation_Homo sapiens_hsa005311.40430170
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.39218671
19Renin-angiotensin system_Homo sapiens_hsa046141.39079103
20mTOR signaling pathway_Homo sapiens_hsa041501.34461882
21Bladder cancer_Homo sapiens_hsa052191.34194083
22Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.32533688
23One carbon pool by folate_Homo sapiens_hsa006701.31789705
24Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.31403658
25Proteoglycans in cancer_Homo sapiens_hsa052051.30627799
26ECM-receptor interaction_Homo sapiens_hsa045121.28139919
27Fatty acid degradation_Homo sapiens_hsa000711.27860666
28Prion diseases_Homo sapiens_hsa050201.26699971
29Cyanoamino acid metabolism_Homo sapiens_hsa004601.23114210
30Central carbon metabolism in cancer_Homo sapiens_hsa052301.22818048
31Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.20397843
32Antigen processing and presentation_Homo sapiens_hsa046121.18835916
33Thyroid cancer_Homo sapiens_hsa052161.17594371
34Pancreatic cancer_Homo sapiens_hsa052121.15234824
35Adherens junction_Homo sapiens_hsa045201.13466368
36Tight junction_Homo sapiens_hsa045301.11914166
37Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.11532375
38Leukocyte transendothelial migration_Homo sapiens_hsa046701.11033900
39Non-small cell lung cancer_Homo sapiens_hsa052231.08663798
40Fat digestion and absorption_Homo sapiens_hsa049751.06598797
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.02383578
42Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.01437006
43Carbon metabolism_Homo sapiens_hsa012001.01367267
44Thyroid hormone synthesis_Homo sapiens_hsa049181.01351461
45Endometrial cancer_Homo sapiens_hsa052131.00683968
46Phenylalanine metabolism_Homo sapiens_hsa003601.00433250
47Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.00119420
48MicroRNAs in cancer_Homo sapiens_hsa052060.99693215
49Vitamin B6 metabolism_Homo sapiens_hsa007500.99641524
50AMPK signaling pathway_Homo sapiens_hsa041520.99081141
51Vitamin digestion and absorption_Homo sapiens_hsa049770.96228104
52AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.95306532
53Amoebiasis_Homo sapiens_hsa051460.94513377
54Acute myeloid leukemia_Homo sapiens_hsa052210.93799029
55Other glycan degradation_Homo sapiens_hsa005110.91924540
56Starch and sucrose metabolism_Homo sapiens_hsa005000.90858753
57Viral carcinogenesis_Homo sapiens_hsa052030.90549620
58Renal cell carcinoma_Homo sapiens_hsa052110.90055437
59Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.89486368
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.88756679
61Biosynthesis of amino acids_Homo sapiens_hsa012300.88243519
62Fatty acid metabolism_Homo sapiens_hsa012120.88012328
63Toxoplasmosis_Homo sapiens_hsa051450.86246072
64Lysosome_Homo sapiens_hsa041420.85839362
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.85825764
66Arginine and proline metabolism_Homo sapiens_hsa003300.84444591
67Tryptophan metabolism_Homo sapiens_hsa003800.84371690
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.83821608
69Glioma_Homo sapiens_hsa052140.83035344
70Insulin signaling pathway_Homo sapiens_hsa049100.82964142
71mRNA surveillance pathway_Homo sapiens_hsa030150.82940796
72Prostate cancer_Homo sapiens_hsa052150.82384180
73Sulfur metabolism_Homo sapiens_hsa009200.81793423
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.81343236
75Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.81255462
76Type II diabetes mellitus_Homo sapiens_hsa049300.80600275
77Pentose phosphate pathway_Homo sapiens_hsa000300.80522866
78PPAR signaling pathway_Homo sapiens_hsa033200.77790624
79Propanoate metabolism_Homo sapiens_hsa006400.77222770
80Platelet activation_Homo sapiens_hsa046110.77132328
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.76571120
82Glucagon signaling pathway_Homo sapiens_hsa049220.76292862
83Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.74626446
84ErbB signaling pathway_Homo sapiens_hsa040120.73988077
85Viral myocarditis_Homo sapiens_hsa054160.73621537
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.73183569
87Galactose metabolism_Homo sapiens_hsa000520.71960979
88Pyruvate metabolism_Homo sapiens_hsa006200.71921231
89Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.71903662
90Tyrosine metabolism_Homo sapiens_hsa003500.70265393
91Bile secretion_Homo sapiens_hsa049760.69742948
92Colorectal cancer_Homo sapiens_hsa052100.68951198
93Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.68884175
94VEGF signaling pathway_Homo sapiens_hsa043700.68363142
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68123866
96Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67683397
97HTLV-I infection_Homo sapiens_hsa051660.67492115
98Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.67231077
99Glycerolipid metabolism_Homo sapiens_hsa005610.66784000
100Histidine metabolism_Homo sapiens_hsa003400.66683483
101Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.66402245
102Prolactin signaling pathway_Homo sapiens_hsa049170.65816258
103Basal cell carcinoma_Homo sapiens_hsa052170.65609965
104Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.64625107
105B cell receptor signaling pathway_Homo sapiens_hsa046620.62807608
106Dilated cardiomyopathy_Homo sapiens_hsa054140.62043719
107Hippo signaling pathway_Homo sapiens_hsa043900.60866424
108Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59309756
109Hepatitis B_Homo sapiens_hsa051610.57913727
110Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.57293405
111Estrogen signaling pathway_Homo sapiens_hsa049150.56689237
112Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55813992
113Notch signaling pathway_Homo sapiens_hsa043300.55429804
114Fatty acid biosynthesis_Homo sapiens_hsa000610.55308087
115Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.55039252
116p53 signaling pathway_Homo sapiens_hsa041150.55016943
117Vibrio cholerae infection_Homo sapiens_hsa051100.54848800
118Pathways in cancer_Homo sapiens_hsa052000.54697653
119Pancreatic secretion_Homo sapiens_hsa049720.54567991
120Cell cycle_Homo sapiens_hsa041100.54346936
121Apoptosis_Homo sapiens_hsa042100.54261567
122Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54239932
123PI3K-Akt signaling pathway_Homo sapiens_hsa041510.53902154
124Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53677493
125Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.53669696
126Cysteine and methionine metabolism_Homo sapiens_hsa002700.52494682
127Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.52338475
128Melanoma_Homo sapiens_hsa052180.50190492
129Hepatitis C_Homo sapiens_hsa051600.50116269
130Drug metabolism - other enzymes_Homo sapiens_hsa009830.49998266
131Inositol phosphate metabolism_Homo sapiens_hsa005620.48942537
132TGF-beta signaling pathway_Homo sapiens_hsa043500.48882321

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