MKRN3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains a RING (C3HC4) zinc finger motif and several C3H zinc finger motifs. This gene is intronless and imprinted, with expression only from the paternal allele. Disruption of the imprinting at this locus may contribute to Prader-Willi syndrome. An antisense RNA of unknown function has been found overlapping this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)7.69880159
2nucleobase catabolic process (GO:0046113)5.78464571
3response to pheromone (GO:0019236)5.76027753
4neuron recognition (GO:0008038)5.11184739
5dendritic spine morphogenesis (GO:0060997)4.99756940
6establishment of mitochondrion localization (GO:0051654)4.79609092
7central nervous system myelination (GO:0022010)4.76383081
8axon ensheathment in central nervous system (GO:0032291)4.76383081
9negative regulation of microtubule polymerization (GO:0031115)4.70465013
10peptidyl-arginine omega-N-methylation (GO:0035247)4.66991643
11layer formation in cerebral cortex (GO:0021819)4.66991552
12neuron cell-cell adhesion (GO:0007158)4.50763204
13axonal fasciculation (GO:0007413)4.32255911
14behavioral response to nicotine (GO:0035095)4.26589467
15peptidyl-arginine methylation (GO:0018216)4.23631994
16peptidyl-arginine N-methylation (GO:0035246)4.23631994
17establishment of mitochondrion localization, microtubule-mediated (GO:0034643)4.14541370
18mitochondrion transport along microtubule (GO:0047497)4.14541370
19neural tube formation (GO:0001841)4.12901949
20cell-cell junction maintenance (GO:0045217)4.10784144
21cell migration in hindbrain (GO:0021535)4.09006868
22central nervous system projection neuron axonogenesis (GO:0021952)4.02667893
23protein localization to synapse (GO:0035418)3.88841943
24histone arginine methylation (GO:0034969)3.81459451
25cell junction maintenance (GO:0034331)3.59630211
26positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.57385745
27epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.56303806
28hippocampus development (GO:0021766)3.55272272
29regulation of cilium movement (GO:0003352)3.53699848
30mitochondrial fragmentation involved in apoptotic process (GO:0043653)3.51361618
31regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.50700369
32startle response (GO:0001964)3.50509653
33establishment of nucleus localization (GO:0040023)3.46706081
34forebrain neuron differentiation (GO:0021879)3.44691820
35vocalization behavior (GO:0071625)3.44472438
36protein polyglutamylation (GO:0018095)3.44128829
37positive regulation of synapse assembly (GO:0051965)3.40001949
38ectodermal placode formation (GO:0060788)3.38678413
39cilium morphogenesis (GO:0060271)3.34558431
40regulation of short-term neuronal synaptic plasticity (GO:0048172)3.34257568
41somite development (GO:0061053)3.32519041
42neuron fate determination (GO:0048664)3.31640057
43dendrite morphogenesis (GO:0048813)3.27616789
44fucose catabolic process (GO:0019317)3.25437732
45L-fucose metabolic process (GO:0042354)3.25437732
46L-fucose catabolic process (GO:0042355)3.25437732
47regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.24925156
48cerebral cortex radially oriented cell migration (GO:0021799)3.22880787
49epithelial cilium movement (GO:0003351)3.22725830
50regulation of respiratory system process (GO:0044065)3.21738704
51regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.17169093
52cholesterol biosynthetic process (GO:0006695)3.17038213
53DNA damage response, detection of DNA damage (GO:0042769)3.15922542
54fatty acid elongation (GO:0030497)3.12038335
55negative regulation of oligodendrocyte differentiation (GO:0048715)3.10715024
56negative regulation of axon extension (GO:0030517)3.10706533
57synaptic vesicle exocytosis (GO:0016079)3.09145461
58negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.08912962
59cerebral cortex neuron differentiation (GO:0021895)3.06649251
60central nervous system neuron axonogenesis (GO:0021955)3.06088434
61sterol biosynthetic process (GO:0016126)3.04498223
62regulation of respiratory gaseous exchange (GO:0043576)3.04472007
63regulation of mammary gland epithelial cell proliferation (GO:0033599)3.04305800
64substrate-independent telencephalic tangential migration (GO:0021826)3.01843446
65substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.01843446
66regulation of microtubule polymerization (GO:0031113)3.01039065
67regulation of mitochondrial translation (GO:0070129)3.00518955
68spinal cord development (GO:0021510)3.00426839
69calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.00238593
70resolution of meiotic recombination intermediates (GO:0000712)2.99648828
71apical protein localization (GO:0045176)2.99098432
72ubiquinone metabolic process (GO:0006743)2.99098036
73intraciliary transport (GO:0042073)2.99007434
74cranial nerve morphogenesis (GO:0021602)2.98681091
75G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.97758238
76axon extension (GO:0048675)2.93211565
77retinal cone cell development (GO:0046549)2.92562927
78negative regulation of transcription regulatory region DNA binding (GO:2000678)2.91725245
79hindbrain development (GO:0030902)2.90715588
80regulation of synapse assembly (GO:0051963)2.89873228
81regulation of chemokine-mediated signaling pathway (GO:0070099)2.88371346
82negative regulation of axon extension involved in axon guidance (GO:0048843)2.87199582
83spinal cord association neuron differentiation (GO:0021527)2.86695467
84sequestering of actin monomers (GO:0042989)2.86002494
85synapse assembly (GO:0007416)2.85114335
86cilium organization (GO:0044782)2.84766473
87negative regulation of axonogenesis (GO:0050771)2.84611550
88transmission of nerve impulse (GO:0019226)2.84412407
89cilium assembly (GO:0042384)2.83724308
90positive regulation of mitochondrial fission (GO:0090141)2.83168738
91gamma-aminobutyric acid transport (GO:0015812)2.82727942
92neuronal stem cell maintenance (GO:0097150)2.82382894
93DNA double-strand break processing (GO:0000729)2.81989686
94regulation of synapse structural plasticity (GO:0051823)2.81593465
95membrane hyperpolarization (GO:0060081)2.80508180
96cornea development in camera-type eye (GO:0061303)2.78649498
97neuron migration (GO:0001764)2.78449671
98clathrin coat assembly (GO:0048268)2.78407560
99positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.77516541
100olfactory bulb development (GO:0021772)2.77454871
101ubiquinone biosynthetic process (GO:0006744)2.75926837
102cilium movement (GO:0003341)2.75541310
103positive regulation of dendritic spine morphogenesis (GO:0061003)2.74117072
104cerebellum development (GO:0021549)2.74113773
105regulation of long-term neuronal synaptic plasticity (GO:0048169)2.73274826
106negative regulation of synaptic transmission, GABAergic (GO:0032229)2.72751099
107positive regulation of synapse maturation (GO:0090129)2.72410845
108polarized epithelial cell differentiation (GO:0030859)2.72358513
109protein localization to cilium (GO:0061512)2.72149816
110regulation of microtubule-based movement (GO:0060632)2.72105243
111photoreceptor cell development (GO:0042461)2.71496828
112positive regulation of microtubule polymerization or depolymerization (GO:0031112)2.71463233
113glycosphingolipid biosynthetic process (GO:0006688)2.71268420
114lateral sprouting from an epithelium (GO:0060601)2.71186911
115positive regulation of dendritic spine development (GO:0060999)2.71023626
116regulation of synapse organization (GO:0050807)2.69825581
117axoneme assembly (GO:0035082)2.68129527
118positive regulation of protein depolymerization (GO:1901881)2.68109891
119exploration behavior (GO:0035640)2.66761011
120dendrite development (GO:0016358)2.65099467
121glial cell proliferation (GO:0014009)2.64322984
122regulation of oligodendrocyte differentiation (GO:0048713)2.62816337
123cell differentiation in spinal cord (GO:0021515)2.61636293
124regulation of feeding behavior (GO:0060259)2.61148631
125negative regulation of axon guidance (GO:1902668)2.61091214
126regulation of development, heterochronic (GO:0040034)2.60511365
127base-excision repair, AP site formation (GO:0006285)2.60125737
128positive regulation of oligodendrocyte differentiation (GO:0048714)2.59389154
129protein-cofactor linkage (GO:0018065)2.59184336
130cerebellar Purkinje cell layer development (GO:0021680)2.58696381
131negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.58573138
132negative regulation of translation, ncRNA-mediated (GO:0040033)2.58573138
133regulation of translation, ncRNA-mediated (GO:0045974)2.58573138
134limb bud formation (GO:0060174)2.57807384
135dendritic spine organization (GO:0097061)2.57629324
136retinal ganglion cell axon guidance (GO:0031290)2.56115597
137postsynaptic membrane organization (GO:0001941)2.55752453
138presynaptic membrane assembly (GO:0097105)2.55743566
139regulation of NFAT protein import into nucleus (GO:0051532)2.55348250
140limb development (GO:0060173)2.54763586
141appendage development (GO:0048736)2.54763586
142nonmotile primary cilium assembly (GO:0035058)2.54420310
143locomotory exploration behavior (GO:0035641)2.54220042
144genetic imprinting (GO:0071514)2.53758620
145head development (GO:0060322)2.53551443
146regulation of synaptic vesicle exocytosis (GO:2000300)2.53254839
147mechanosensory behavior (GO:0007638)2.53120443
148presynaptic membrane organization (GO:0097090)2.53099456
149regulation of collateral sprouting (GO:0048670)2.53091154
150regulation of extent of cell growth (GO:0061387)2.51682283
151dorsal/ventral axis specification (GO:0009950)2.51481092
152establishment of planar polarity (GO:0001736)2.51012705
153establishment of tissue polarity (GO:0007164)2.51012705
154eye photoreceptor cell development (GO:0042462)2.50069030
155regulation of neuronal synaptic plasticity (GO:0048168)2.49878634
156regulation of glutamate receptor signaling pathway (GO:1900449)2.49736969
157chaperone-mediated protein transport (GO:0072321)2.49515562
158regulation of axon extension (GO:0030516)2.49392123
159negative regulation of telomere maintenance (GO:0032205)2.48831077
160behavioral response to ethanol (GO:0048149)2.47853007
161sympathetic nervous system development (GO:0048485)2.47166245
162auditory behavior (GO:0031223)2.47101494
163regulation of timing of cell differentiation (GO:0048505)2.46073336
164synaptic transmission, cholinergic (GO:0007271)2.44007164
165negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.42596811
166synaptic transmission, glutamatergic (GO:0035249)2.41605022
167protein complex biogenesis (GO:0070271)2.40260679
168regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.38804070
169respiratory chain complex IV assembly (GO:0008535)2.38677398
170ionotropic glutamate receptor signaling pathway (GO:0035235)2.38487294
171reciprocal meiotic recombination (GO:0007131)2.38290536
172reciprocal DNA recombination (GO:0035825)2.38290536

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.37278886
2NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.58505253
3EZH2_27304074_Chip-Seq_ESCs_Mouse2.64400782
4ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.60116202
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.59588636
6VDR_22108803_ChIP-Seq_LS180_Human2.47540126
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.45374527
8STAT6_21828071_ChIP-Seq_BEAS2B_Human2.33275331
9CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.30613232
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.25804323
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.25018052
12* EZH2_27294783_Chip-Seq_ESCs_Mouse2.24236458
13ZFP281_18757296_ChIP-ChIP_E14_Mouse2.23897500
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.22703590
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.22703590
16ZNF274_21170338_ChIP-Seq_K562_Hela2.16660697
17AR_21572438_ChIP-Seq_LNCaP_Human2.15887262
18SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.15596202
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.13346058
20JARID2_20075857_ChIP-Seq_MESCs_Mouse2.11815425
21GBX2_23144817_ChIP-Seq_PC3_Human2.07642493
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.07445368
23EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.05791686
24CBX2_27304074_Chip-Seq_ESCs_Mouse2.05441939
25SUZ12_27294783_Chip-Seq_ESCs_Mouse2.03719810
26REST_21632747_ChIP-Seq_MESCs_Mouse2.03036150
27EWS_26573619_Chip-Seq_HEK293_Human2.02299763
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.01685363
29EED_16625203_ChIP-ChIP_MESCs_Mouse2.00917947
30PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.99500150
31RNF2_27304074_Chip-Seq_ESCs_Mouse1.96923648
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.95716369
33SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.89574918
34SOX2_18555785_ChIP-Seq_MESCs_Mouse1.89145051
35RING1B_27294783_Chip-Seq_NPCs_Mouse1.88330479
36P300_19829295_ChIP-Seq_ESCs_Human1.86440583
37REST_18959480_ChIP-ChIP_MESCs_Mouse1.85356424
38ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.84568121
39* RNF2_27304074_Chip-Seq_NSC_Mouse1.82763658
40HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.79387545
41IRF1_19129219_ChIP-ChIP_H3396_Human1.71184841
42ERG_21242973_ChIP-ChIP_JURKAT_Human1.70374162
43TP63_19390658_ChIP-ChIP_HaCaT_Human1.68876769
44* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.68610417
45SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.68593636
46KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.67823326
47WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.67687212
48SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.67479762
49MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.67361593
50SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.64511698
51MTF2_20144788_ChIP-Seq_MESCs_Mouse1.63886809
52NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.62686716
53RING1B_27294783_Chip-Seq_ESCs_Mouse1.61788266
54SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.61697742
55* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.60150031
56RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.58807685
57RBPJ_22232070_ChIP-Seq_NCS_Mouse1.56292164
58SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.55527782
59CTBP2_25329375_ChIP-Seq_LNCAP_Human1.54631051
60POU5F1_16153702_ChIP-ChIP_HESCs_Human1.53032558
61E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.52965302
62TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.52496120
63RARB_27405468_Chip-Seq_BRAIN_Mouse1.51899059
64DROSHA_22980978_ChIP-Seq_HELA_Human1.51875828
65* GABP_17652178_ChIP-ChIP_JURKAT_Human1.51334772
66SOX2_16153702_ChIP-ChIP_HESCs_Human1.50778516
67MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.49648621
68KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.47393171
69ER_23166858_ChIP-Seq_MCF-7_Human1.47011137
70MYC_18940864_ChIP-ChIP_HL60_Human1.46545243
71CBP_20019798_ChIP-Seq_JUKART_Human1.43822011
72IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.43822011
73CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.43341258
74WT1_19549856_ChIP-ChIP_CCG9911_Human1.42931313
75PIAS1_25552417_ChIP-Seq_VCAP_Human1.41551020
76* EST1_17652178_ChIP-ChIP_JURKAT_Human1.41421267
77SMAD4_21799915_ChIP-Seq_A2780_Human1.39388362
78UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.39294253
79TP53_20018659_ChIP-ChIP_R1E_Mouse1.36549324
80MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.34557877
81* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.33805266
82* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.33611808
83ZFP281_27345836_Chip-Seq_ESCs_Mouse1.32917881
84FUS_26573619_Chip-Seq_HEK293_Human1.32777687
85SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.32154968
86* STAT3_23295773_ChIP-Seq_U87_Human1.31482524
87SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30043864
88AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.29703002
89GATA1_26923725_Chip-Seq_HPCs_Mouse1.29394598
90SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.29345604
91TP53_22573176_ChIP-Seq_HFKS_Human1.25994114
92SMAD3_21741376_ChIP-Seq_EPCs_Human1.24260558
93AR_25329375_ChIP-Seq_VCAP_Human1.24112108
94SALL1_21062744_ChIP-ChIP_HESCs_Human1.23904888
95TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23458196
96STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.23451560
97SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22512162
98* TCF4_23295773_ChIP-Seq_U87_Human1.20610705
99NOTCH1_21737748_ChIP-Seq_TLL_Human1.20407097
100KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.19954844
101KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.19954844
102KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.19954844
103IGF1R_20145208_ChIP-Seq_DFB_Human1.19184384
104KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18198844
105GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.17767662
106FLI1_27457419_Chip-Seq_LIVER_Mouse1.15267727
107NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.14962647
108* RUNX2_22187159_ChIP-Seq_PCA_Human1.14671514
109* ELK1_19687146_ChIP-ChIP_HELA_Human1.14472835
110ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.13763325
111ETV2_25802403_ChIP-Seq_MESCs_Mouse1.10536129
112MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.09785749
113NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09572559
114RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.09079091
115TCF3_18692474_ChIP-Seq_MESCs_Mouse1.08676773
116BCAT_22108803_ChIP-Seq_LS180_Human1.08072378
117EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06562611
118CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.06473602
119TAF15_26573619_Chip-Seq_HEK293_Human1.06354436
120POU3F1_26484290_ChIP-Seq_ESCss_Mouse1.05633488
121NCOR_22424771_ChIP-Seq_293T_Human1.05215979
122THAP11_20581084_ChIP-Seq_MESCs_Mouse1.04816773
123CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.03796881
124TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.01998004
125OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01266259
126KDM2B_26808549_Chip-Seq_K562_Human1.00920125
127TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99713477
128POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99713477
129PCGF2_27294783_Chip-Seq_ESCs_Mouse0.99679713
130FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.99594591
131TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99565041
132ETS1_20019798_ChIP-Seq_JURKAT_Human0.99506215
133KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.99120198
134TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.98127582
135SOX3_22085726_ChIP-Seq_NPCs_Mouse0.97761793
136DNAJC2_21179169_ChIP-ChIP_NT2_Human0.97760371
137TCF4_22108803_ChIP-Seq_LS180_Human0.97643047
138PCGF2_27294783_Chip-Seq_NPCs_Mouse0.97338382
139TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96960715
140SOX2_19829295_ChIP-Seq_ESCs_Human0.96645661
141NANOG_19829295_ChIP-Seq_ESCs_Human0.96645661
142CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.96302165
143POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.95434932
144NANOG_18555785_Chip-Seq_ESCs_Mouse0.95252881
145ZFP57_27257070_Chip-Seq_ESCs_Mouse0.94748131
146TCF3_18692474_ChIP-Seq_MEFs_Mouse0.94313389
147TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.94308260
148KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.92728954
149MYC_19079543_ChIP-ChIP_MESCs_Mouse0.92445066
150TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.91870344
151PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.91277515
152YAP1_20516196_ChIP-Seq_MESCs_Mouse0.90825320
153SOX2_21211035_ChIP-Seq_LN229_Gbm0.89304700
154SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.88584317
155NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.87525582
156EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.85697952
157ISL1_27105846_Chip-Seq_CPCs_Mouse0.85072342

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003122_maternal_imprinting3.71879587
2MP0000778_abnormal_nervous_system3.64623474
3MP0003880_abnormal_central_pattern3.48406860
4MP0005423_abnormal_somatic_nervous3.11016065
5MP0004859_abnormal_synaptic_plasticity2.98986245
6MP0000537_abnormal_urethra_morphology2.82531782
7MP0004270_analgesia2.81608608
8MP0003123_paternal_imprinting2.53508348
9MP0004133_heterotaxia2.43625403
10MP0003635_abnormal_synaptic_transmissio2.29469378
11MP0003121_genomic_imprinting2.29116171
12MP0010030_abnormal_orbit_morphology2.18961017
13MP0003890_abnormal_embryonic-extraembry2.08566765
14MP0001529_abnormal_vocalization2.08295446
15MP0000955_abnormal_spinal_cord2.08037492
16MP0008789_abnormal_olfactory_epithelium2.06541973
17MP0005646_abnormal_pituitary_gland2.02698159
18MP0002184_abnormal_innervation1.98890510
19MP0002063_abnormal_learning/memory/cond1.92608195
20MP0003787_abnormal_imprinting1.82098776
21MP0003119_abnormal_digestive_system1.81593120
22MP0003861_abnormal_nervous_system1.80534379
23MP0006276_abnormal_autonomic_nervous1.77659703
24MP0002734_abnormal_mechanical_nocicepti1.76568007
25MP0005394_taste/olfaction_phenotype1.76244235
26MP0005499_abnormal_olfactory_system1.76244235
27MP0005253_abnormal_eye_physiology1.76119542
28MP0003646_muscle_fatigue1.76065094
29MP0002736_abnormal_nociception_after1.73200838
30MP0001486_abnormal_startle_reflex1.70145326
31MP0002064_seizures1.69692363
32MP0008995_early_reproductive_senescence1.67631648
33MP0004811_abnormal_neuron_physiology1.67340416
34MP0006072_abnormal_retinal_apoptosis1.66497404
35MP0002653_abnormal_ependyma_morphology1.63179814
36MP0003136_yellow_coat_color1.63145661
37MP0002152_abnormal_brain_morphology1.60092236
38MP0000569_abnormal_digit_pigmentation1.60087069
39MP0004885_abnormal_endolymph1.59942741
40MP0003011_delayed_dark_adaptation1.59923211
41MP0002928_abnormal_bile_duct1.58582732
42MP0009745_abnormal_behavioral_response1.57813528
43MP0008877_abnormal_DNA_methylation1.54067021
44MP0005645_abnormal_hypothalamus_physiol1.52457608
45MP0002882_abnormal_neuron_morphology1.52373391
46MP0009046_muscle_twitch1.47929690
47MP0000049_abnormal_middle_ear1.47195216
48MP0002572_abnormal_emotion/affect_behav1.46659211
49MP0003329_amyloid_beta_deposits1.44485723
50MP0002733_abnormal_thermal_nociception1.44200143
51MP0002272_abnormal_nervous_system1.39027866
52MP0003283_abnormal_digestive_organ1.38917709
53MP0000462_abnormal_digestive_system1.36558498
54MP0002557_abnormal_social/conspecific_i1.33027534
55MP0001968_abnormal_touch/_nociception1.30498180
56MP0003385_abnormal_body_wall1.28752949
57MP0001348_abnormal_lacrimal_gland1.28313524
58MP0004142_abnormal_muscle_tone1.27937790
59MP0003942_abnormal_urinary_system1.27204887
60MP0002752_abnormal_somatic_nervous1.25775061
61MP0003632_abnormal_nervous_system1.23996214
62MP0004858_abnormal_nervous_system1.23122588
63MP0002751_abnormal_autonomic_nervous1.23005493
64MP0000631_abnormal_neuroendocrine_gland1.19687629
65MP0002638_abnormal_pupillary_reflex1.17439202
66MP0005084_abnormal_gallbladder_morpholo1.17065390
67MP0000920_abnormal_myelination1.16475848
68MP0008058_abnormal_DNA_repair1.16393836
69MP0001970_abnormal_pain_threshold1.15968461
70MP0001440_abnormal_grooming_behavior1.14523431
71MP0002066_abnormal_motor_capabilities/c1.14299037
72MP0004924_abnormal_behavior1.14020563
73MP0005386_behavior/neurological_phenoty1.14020563
74MP0002938_white_spotting1.13539435
75MP0002822_catalepsy1.12339083
76MP0001984_abnormal_olfaction1.11785954
77MP0005171_absent_coat_pigmentation1.11461834
78MP0001502_abnormal_circadian_rhythm1.10230204
79MP0002234_abnormal_pharynx_morphology1.09694641
80MP0000566_synostosis1.08620004
81MP0003937_abnormal_limbs/digits/tail_de1.06833183
82MP0009379_abnormal_foot_pigmentation1.06383378
83MP0002067_abnormal_sensory_capabilities1.05973802
84MP0002233_abnormal_nose_morphology1.05778436
85MP0002837_dystrophic_cardiac_calcinosis1.05392104
86MP0000647_abnormal_sebaceous_gland1.05088492
87MP0004043_abnormal_pH_regulation1.05010289
88MP0006292_abnormal_olfactory_placode1.04294219
89MP0001501_abnormal_sleep_pattern1.04088626
90MP0003938_abnormal_ear_development1.03999701
91MP0003755_abnormal_palate_morphology1.02977313
92MP0004742_abnormal_vestibular_system1.01928679
93MP0005391_vision/eye_phenotype1.01901522
94MP0001188_hyperpigmentation1.01247143
95MP0003698_abnormal_male_reproductive1.00380330
96MP0002081_perinatal_lethality0.99625930
97MP0000427_abnormal_hair_cycle0.99232750
98MP0001943_abnormal_respiration0.98872946
99MP0002735_abnormal_chemical_nociception0.98168721
100MP0001986_abnormal_taste_sensitivity0.97195496
101MP0003315_abnormal_perineum_morphology0.96146415
102MP0005248_abnormal_Harderian_gland0.96060468
103MP0001905_abnormal_dopamine_level0.95177147
104MP0005187_abnormal_penis_morphology0.94687530
105MP0002697_abnormal_eye_size0.93648328
106MP0002249_abnormal_larynx_morphology0.93632792
107MP0001270_distended_abdomen0.92894575
108MP0002084_abnormal_developmental_patter0.92648753
109MP0002160_abnormal_reproductive_system0.92257715
110MP0003115_abnormal_respiratory_system0.91643516
111MP0001485_abnormal_pinna_reflex0.90503814
112MP0003634_abnormal_glial_cell0.90364887
113MP0005195_abnormal_posterior_eye0.90030575
114MP0002095_abnormal_skin_pigmentation0.89868881
115MP0001293_anophthalmia0.88360757
116MP0001286_abnormal_eye_development0.88161483
117MP0008872_abnormal_physiological_respon0.86653663
118MP0003718_maternal_effect0.85555618
119MP0000026_abnormal_inner_ear0.85133825
120MP0002210_abnormal_sex_determination0.85032217
121MP0002116_abnormal_craniofacial_bone0.82148489
122MP0002102_abnormal_ear_morphology0.82013310
123MP0001929_abnormal_gametogenesis0.81637159
124MP0005551_abnormal_eye_electrophysiolog0.81614558
125MP0008932_abnormal_embryonic_tissue0.80455319
126MP0002932_abnormal_joint_morphology0.80392125
127MP0002069_abnormal_eating/drinking_beha0.80112640
128MP0002282_abnormal_trachea_morphology0.79723479
129MP0003631_nervous_system_phenotype0.76341035
130MP0002092_abnormal_eye_morphology0.75599309
131MP0005409_darkened_coat_color0.75589257
132MP0000534_abnormal_ureter_morphology0.75492300
133MP0001849_ear_inflammation0.75230817

Predicted human phenotypes

RankGene SetZ-score
1True hermaphroditism (HP:0010459)3.96175565
2Pancreatic cysts (HP:0001737)3.92800719
3Abnormality of the corticospinal tract (HP:0002492)3.66092400
4Amyotrophic lateral sclerosis (HP:0007354)3.56182048
5Pancreatic fibrosis (HP:0100732)3.55320439
6Nephronophthisis (HP:0000090)3.33741810
7Molar tooth sign on MRI (HP:0002419)3.31646996
8Abnormality of midbrain morphology (HP:0002418)3.31646996
9Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.29886974
10Degeneration of the lateral corticospinal tracts (HP:0002314)3.29886974
11Myokymia (HP:0002411)3.17865413
12Chronic hepatic failure (HP:0100626)3.17034932
13Visual hallucinations (HP:0002367)3.16654663
14Ankle clonus (HP:0011448)3.14863782
15Mutism (HP:0002300)3.12274442
16Hypoplasia of the brainstem (HP:0002365)3.10417107
17Aplasia/Hypoplasia of the brainstem (HP:0007362)3.10417107
18Polyphagia (HP:0002591)3.08343118
19Limb dystonia (HP:0002451)3.06887585
20Medial flaring of the eyebrow (HP:0010747)3.05431111
21Morphological abnormality of the pyramidal tract (HP:0002062)3.00525402
22Neurofibrillary tangles (HP:0002185)3.00125871
23Overriding aorta (HP:0002623)2.94705901
24Cerebellar dysplasia (HP:0007033)2.92173577
25Lissencephaly (HP:0001339)2.90972530
26Focal seizures (HP:0007359)2.89942618
27Spastic gait (HP:0002064)2.89213702
28Abnormality of the renal medulla (HP:0100957)2.86666117
29Renal duplication (HP:0000075)2.85977801
30Cerebral inclusion bodies (HP:0100314)2.82288173
31Tubulointerstitial nephritis (HP:0001970)2.77790287
32Termporal pattern (HP:0011008)2.77378666
33Insidious onset (HP:0003587)2.77378666
34Hyperacusis (HP:0010780)2.75067001
35Supranuclear gaze palsy (HP:0000605)2.75066132
36Insomnia (HP:0100785)2.73350048
37Oligodactyly (hands) (HP:0001180)2.68061201
38Broad-based gait (HP:0002136)2.67966044
39Congenital primary aphakia (HP:0007707)2.64365242
40Abnormal biliary tract physiology (HP:0012439)2.59432961
41Bile duct proliferation (HP:0001408)2.59432961
42Nephrogenic diabetes insipidus (HP:0009806)2.52861276
43Cystic liver disease (HP:0006706)2.51476430
44Elfin facies (HP:0004428)2.49825540
45Focal motor seizures (HP:0011153)2.49016894
46Abnormality of the labia minora (HP:0012880)2.47564216
47Abnormality of the diencephalon (HP:0010662)2.46612907
48Absent speech (HP:0001344)2.45884664
49Congenital stationary night blindness (HP:0007642)2.43602015
50Poor speech (HP:0002465)2.43524204
51Increased serum pyruvate (HP:0003542)2.41443725
52Abnormality of glycolysis (HP:0004366)2.41443725
53Lipid accumulation in hepatocytes (HP:0006561)2.39384290
54Cerebral hypomyelination (HP:0006808)2.39364968
55Urinary urgency (HP:0000012)2.35721159
56Specific learning disability (HP:0001328)2.35587994
57Coronal craniosynostosis (HP:0004440)2.35272979
58Flat cornea (HP:0007720)2.35208447
59Astrocytoma (HP:0009592)2.33110628
60Abnormality of the astrocytes (HP:0100707)2.33110628
61Ependymoma (HP:0002888)2.30954404
62Anencephaly (HP:0002323)2.28369795
63Absence seizures (HP:0002121)2.27675650
64Failure to thrive in infancy (HP:0001531)2.27301430
65Inability to walk (HP:0002540)2.27126436
66Epileptic encephalopathy (HP:0200134)2.24680381
67Renovascular hypertension (HP:0100817)2.24622733
68Postaxial foot polydactyly (HP:0001830)2.23993520
69Abnormality of the renal cortex (HP:0011035)2.23936426
70Acute necrotizing encephalopathy (HP:0006965)2.23821906
71Megalocornea (HP:0000485)2.23226302
72Sclerocornea (HP:0000647)2.21415873
73Akinesia (HP:0002304)2.18540475
74Optic nerve hypoplasia (HP:0000609)2.17912175
75Dialeptic seizures (HP:0011146)2.12676423
76Aplasia/Hypoplasia of the tongue (HP:0010295)2.12305598
77Hemiparesis (HP:0001269)2.11522006
78Sacral dimple (HP:0000960)2.11348094
79Poor eye contact (HP:0000817)2.09739803
80Postaxial hand polydactyly (HP:0001162)2.09489477
81Increased corneal curvature (HP:0100692)2.08661021
82Keratoconus (HP:0000563)2.08661021
83Truncal ataxia (HP:0002078)2.07324796
84Narrow forehead (HP:0000341)2.06771403
85Progressive cerebellar ataxia (HP:0002073)2.05832644
86Preaxial hand polydactyly (HP:0001177)2.04848479
87Pendular nystagmus (HP:0012043)2.04290593
88Genital tract atresia (HP:0001827)2.03890171
89Concave nail (HP:0001598)2.03312860
90Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.03166437
91Congenital hepatic fibrosis (HP:0002612)2.03139792
92Septo-optic dysplasia (HP:0100842)2.02509813
93Increased hepatocellular lipid droplets (HP:0006565)2.01985136
94Agitation (HP:0000713)2.01801176
95Gait imbalance (HP:0002141)2.01493801
96Myelomeningocele (HP:0002475)2.01403066
97Absent septum pellucidum (HP:0001331)2.01001966
98Vaginal atresia (HP:0000148)2.00979280
99Occipital encephalocele (HP:0002085)1.99979994
100Poor coordination (HP:0002370)1.98138632
101Scanning speech (HP:0002168)1.98075784
102Intestinal atresia (HP:0011100)1.97941031
103Progressive macrocephaly (HP:0004481)1.97575172
104Acute encephalopathy (HP:0006846)1.95373533
105Progressive inability to walk (HP:0002505)1.95260591
106Patellar aplasia (HP:0006443)1.94903064
107Oligodactyly (HP:0012165)1.94443702
108Abnormal mitochondria in muscle tissue (HP:0008316)1.94348711
109Pachygyria (HP:0001302)1.93803697
110Hyperthyroidism (HP:0000836)1.93566838
111Increased CSF lactate (HP:0002490)1.93498436
112Generalized hypotonia (HP:0001290)1.93468641
113Mitochondrial inheritance (HP:0001427)1.92880268
114Male pseudohermaphroditism (HP:0000037)1.92456736
115Medulloblastoma (HP:0002885)1.91862706
116Megalencephaly (HP:0001355)1.91745514
117Sleep apnea (HP:0010535)1.91597832
118Rib fusion (HP:0000902)1.91375651
119Amblyopia (HP:0000646)1.91298097
120Drooling (HP:0002307)1.90711593
121Excessive salivation (HP:0003781)1.90711593
122Attenuation of retinal blood vessels (HP:0007843)1.89795922
123Tented upper lip vermilion (HP:0010804)1.89788948
124Poor suck (HP:0002033)1.89678854
125Febrile seizures (HP:0002373)1.88385690
126Tubular atrophy (HP:0000092)1.87602084
127Thyroid-stimulating hormone excess (HP:0002925)1.87110712
128Hyperglycinemia (HP:0002154)1.86682139
129Aplasia/Hypoplasia of the patella (HP:0006498)1.86673121
130Abnormal social behavior (HP:0012433)1.86566415
131Impaired social interactions (HP:0000735)1.86566415
132Partial agenesis of the corpus callosum (HP:0001338)1.86410412
133Dandy-Walker malformation (HP:0001305)1.85105777
134Colon cancer (HP:0003003)1.84617533
135Bowel incontinence (HP:0002607)1.83546755
136Hypsarrhythmia (HP:0002521)1.83432554
137Abnormal eating behavior (HP:0100738)1.83257308
138Split foot (HP:0001839)1.82596363
139Abnormality of the septum pellucidum (HP:0007375)1.81459371
140Exotropia (HP:0000577)1.81104384
141Severe muscular hypotonia (HP:0006829)1.80913595
142Clonus (HP:0002169)1.80761075
143Lower limb muscle weakness (HP:0007340)1.80694391
144Atrophy/Degeneration involving motor neurons (HP:0007373)1.80586789
145Urinary bladder sphincter dysfunction (HP:0002839)1.80490679
146Retinal dysplasia (HP:0007973)1.80466148
147Hypoventilation (HP:0002791)1.79576783
148Aplasia/Hypoplasia of the uvula (HP:0010293)1.78932088
149Abnormal respiratory motile cilium morphology (HP:0005938)1.78095778
150Abnormal respiratory epithelium morphology (HP:0012253)1.78095778
151Hepatocellular necrosis (HP:0001404)1.78011199
152Renal cortical cysts (HP:0000803)1.77910362
153Facial hemangioma (HP:0000329)1.77189074
154Broad alveolar ridges (HP:0000187)1.77154243
155Supernumerary spleens (HP:0009799)1.76998412
156Aplasia/Hypoplasia of the tibia (HP:0005772)1.76730265
157Bifid tongue (HP:0010297)1.75497313
158Anophthalmia (HP:0000528)1.74843097
159Type II lissencephaly (HP:0007260)1.73424273
160Bronchomalacia (HP:0002780)1.73075841
161Esotropia (HP:0000565)1.72828136
162EEG with generalized epileptiform discharges (HP:0011198)1.72827037
163Aganglionic megacolon (HP:0002251)1.71922042
164Patellar dislocation (HP:0002999)1.70404140
165Abnormal ciliary motility (HP:0012262)1.69637017
166Gaze-evoked nystagmus (HP:0000640)1.69279449
167Hemivertebrae (HP:0002937)1.68676063
168Short foot (HP:0001773)1.67867666
169Hyperventilation (HP:0002883)1.67299013
170Prominent nasal bridge (HP:0000426)1.66970067
171Polymicrogyria (HP:0002126)1.66511978
172Abnormal drinking behavior (HP:0030082)1.65789243
173Polydipsia (HP:0001959)1.65789243
174Trigonocephaly (HP:0000243)1.64781021
175Postnatal microcephaly (HP:0005484)1.62961189
176Meningocele (HP:0002435)1.62878859
177Epileptiform EEG discharges (HP:0011182)1.61837631

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK196.72378672
2MARK15.41531840
3MAP3K103.02410742
4PINK12.77920499
5DYRK22.70206711
6FRK2.64622252
7UHMK12.52899247
8BMPR1B2.28115966
9MAP3K92.27206715
10MAP4K22.25553912
11EPHB22.17085924
12BCR2.11930912
13ADRBK22.06183394
14KSR11.99399989
15NTRK21.92884357
16LIMK11.89092678
17MAPK151.88655861
18MINK11.88010177
19CSNK1G31.85071544
20PNCK1.74011142
21MAPK131.69643761
22BRSK21.67779334
23TLK11.67530500
24PHKG21.63471341
25PHKG11.63471341
26MAP3K41.63171098
27CSNK1G21.58351394
28ZAK1.58316172
29TSSK61.53897877
30LATS21.48265692
31ICK1.47252394
32WNK41.47094505
33TGFBR11.46077575
34CSNK1A1L1.43693110
35FGFR21.39673078
36TRIM281.34246512
37PAK61.33051331
38ACVR1B1.30031386
39ERBB31.28952477
40GRK11.28335215
41STK391.21780596
42NUAK11.21566553
43CDK11A1.20976235
44CSNK1G11.20402120
45CDK141.15936531
46TAOK31.14890131
47MKNK21.12053845
48BCKDK1.10013604
49SIK31.09315200
50CDK181.08520597
51DYRK31.08203086
52MAP3K121.07976559
53PLK21.05467086
54NTRK31.03870680
55MAP2K41.01941237
56CDK151.00547524
57MKNK11.00482747
58PKN11.00018463
59TYRO30.97993616
60WEE10.95945319
61CDC70.92260172
62BRD40.89239024
63PAK30.86775133
64CDK50.86383930
65RPS6KA50.84541570
66WNK30.84045464
67MARK30.83681596
68IRAK20.80571041
69INSRR0.80268475
70OXSR10.80131216
71NEK20.79593201
72TNIK0.79116560
73VRK10.78115751
74CHEK20.75989453
75PLK40.73443525
76PRKCE0.72240794
77ERBB20.72121653
78EPHA30.68450086
79DYRK1A0.67033196
80NTRK10.65235451
81ROCK20.64736967
82CDK30.64181651
83CCNB10.62347765
84SIK20.61841311
85BUB10.61690068
86ATR0.61447867
87MAP2K70.60274925
88SRPK10.59182375
89PDK20.59094432
90EPHB10.56351243
91PRKAA10.53873391
92MET0.53578704
93MAP2K60.53170944
94PRKCI0.52915818
95CAMKK20.52651482
96RAF10.52336845
97CSNK1A10.50975387
98PLK10.50122937
99STK160.50082142
100MAPKAPK50.47460196
101MAPK90.46247900
102STK38L0.45983257
103BRSK10.45451944
104PRKACB0.44918877
105PRKACA0.44552322
106PRKCZ0.44472024
107RPS6KA40.44188129
108MAPK120.43231933
109NME10.43186872
110GRK50.43103885
111ATM0.42337149
112CDK80.41442342
113SCYL20.40878877
114CAMK2B0.40622325
115MAPK40.40085051
116SGK4940.39943322
117SGK2230.39943322
118CSNK1E0.39318286
119CSNK1D0.38814164
120TESK10.38567140
121PLK30.37939579
122ALK0.37714981
123MARK20.37550359
124EPHA40.37022888
125TESK20.35877946
126MAP3K60.35784724
127CAMK1G0.35604656
128PRKCG0.35296934
129DDR20.34584445
130CAMK2A0.34184390
131AKT30.33893695
132CAMK40.33137813
133CAMK2D0.31490005
134DAPK20.31291054
135EIF2AK30.31289807
136PRKCQ0.31054212
137ADRBK10.29982648
138CASK0.29676171
139FGFR10.29196064
140AURKA0.29105136
141NEK10.28345586
142STK110.27746091
143ABL20.27000507
144PAK20.25637030
145FYN0.24827054
146DAPK10.24792831
147CDK10.23887241

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.90179578
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.85151939
3Axon guidance_Homo sapiens_hsa043603.14470532
4Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.74567969
5Steroid biosynthesis_Homo sapiens_hsa001002.49619583
6Fanconi anemia pathway_Homo sapiens_hsa034602.10844783
7Butanoate metabolism_Homo sapiens_hsa006502.07009639
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.03295567
9Synaptic vesicle cycle_Homo sapiens_hsa047212.02151652
10Basal cell carcinoma_Homo sapiens_hsa052171.98281379
11Nicotine addiction_Homo sapiens_hsa050331.94940075
12Selenocompound metabolism_Homo sapiens_hsa004501.88685919
13Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.87577416
14Protein export_Homo sapiens_hsa030601.81189087
15Linoleic acid metabolism_Homo sapiens_hsa005911.79877049
16Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.74142958
17GABAergic synapse_Homo sapiens_hsa047271.72283312
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.65654224
19Nitrogen metabolism_Homo sapiens_hsa009101.64053543
20Glutamatergic synapse_Homo sapiens_hsa047241.62963792
21Propanoate metabolism_Homo sapiens_hsa006401.60212715
22mRNA surveillance pathway_Homo sapiens_hsa030151.58994102
23Alcoholism_Homo sapiens_hsa050341.55306497
24Dopaminergic synapse_Homo sapiens_hsa047281.52123633
25Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.49567123
26Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.48916035
27Gap junction_Homo sapiens_hsa045401.48328945
28Parkinsons disease_Homo sapiens_hsa050121.45531753
29Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.45441244
30Hippo signaling pathway_Homo sapiens_hsa043901.45204068
31Maturity onset diabetes of the young_Homo sapiens_hsa049501.45197297
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.42295840
33Hedgehog signaling pathway_Homo sapiens_hsa043401.42089730
34Spliceosome_Homo sapiens_hsa030401.41424368
35Ribosome_Homo sapiens_hsa030101.40757115
36Cocaine addiction_Homo sapiens_hsa050301.40184711
37Serotonergic synapse_Homo sapiens_hsa047261.37970839
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.33642230
39Primary bile acid biosynthesis_Homo sapiens_hsa001201.33408843
40Circadian entrainment_Homo sapiens_hsa047131.32233575
41Fatty acid elongation_Homo sapiens_hsa000621.31884512
42Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.30846131
43Wnt signaling pathway_Homo sapiens_hsa043101.30275931
44Cardiac muscle contraction_Homo sapiens_hsa042601.26892883
45Long-term depression_Homo sapiens_hsa047301.24030323
46Oxidative phosphorylation_Homo sapiens_hsa001901.23010887
47Colorectal cancer_Homo sapiens_hsa052101.21079277
48Taste transduction_Homo sapiens_hsa047421.19807161
49Homologous recombination_Homo sapiens_hsa034401.19709934
50Oocyte meiosis_Homo sapiens_hsa041141.17086511
51Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.17025445
52Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.16096776
53Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.13757186
54Huntingtons disease_Homo sapiens_hsa050161.13438564
55Cholinergic synapse_Homo sapiens_hsa047251.13409783
56Morphine addiction_Homo sapiens_hsa050321.13016598
57Base excision repair_Homo sapiens_hsa034101.12705588
58RNA polymerase_Homo sapiens_hsa030201.11826569
59RNA degradation_Homo sapiens_hsa030181.11810884
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.07053372
61Non-homologous end-joining_Homo sapiens_hsa034501.06095357
62Alzheimers disease_Homo sapiens_hsa050101.04640318
63Melanogenesis_Homo sapiens_hsa049161.03665173
64Phototransduction_Homo sapiens_hsa047440.99665179
65Sulfur metabolism_Homo sapiens_hsa009200.97149152
66ErbB signaling pathway_Homo sapiens_hsa040120.97143060
67ABC transporters_Homo sapiens_hsa020100.94657416
68Peroxisome_Homo sapiens_hsa041460.92879639
69Renal cell carcinoma_Homo sapiens_hsa052110.92580188
70Renin-angiotensin system_Homo sapiens_hsa046140.92070871
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.91078952
72Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.90783419
73Sulfur relay system_Homo sapiens_hsa041220.90280833
74Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.89233234
75Steroid hormone biosynthesis_Homo sapiens_hsa001400.88356587
76Regulation of autophagy_Homo sapiens_hsa041400.86339971
77Tight junction_Homo sapiens_hsa045300.85481161
78Amphetamine addiction_Homo sapiens_hsa050310.84684794
79Vibrio cholerae infection_Homo sapiens_hsa051100.83600507
80Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.82383560
81Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.80757288
82Long-term potentiation_Homo sapiens_hsa047200.79627690
83Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.79344742
84Tryptophan metabolism_Homo sapiens_hsa003800.78752355
85Cysteine and methionine metabolism_Homo sapiens_hsa002700.77631224
86Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.77064000
87beta-Alanine metabolism_Homo sapiens_hsa004100.76924155
88RNA transport_Homo sapiens_hsa030130.75847265
89Collecting duct acid secretion_Homo sapiens_hsa049660.73857900
90Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.73695373
91Ether lipid metabolism_Homo sapiens_hsa005650.71801212
92Mismatch repair_Homo sapiens_hsa034300.70999162
93Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.69753585
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.69737725
95Systemic lupus erythematosus_Homo sapiens_hsa053220.65217411
96Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65048430
97Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.64085581
98Oxytocin signaling pathway_Homo sapiens_hsa049210.63371358
99MicroRNAs in cancer_Homo sapiens_hsa052060.62745780
100Metabolic pathways_Homo sapiens_hsa011000.62591464
101Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.62392929
102Circadian rhythm_Homo sapiens_hsa047100.62193302
103Endometrial cancer_Homo sapiens_hsa052130.61485362
104Fatty acid metabolism_Homo sapiens_hsa012120.61242795
105Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60400369
106Prion diseases_Homo sapiens_hsa050200.60152395
107Purine metabolism_Homo sapiens_hsa002300.59783653
108Caffeine metabolism_Homo sapiens_hsa002320.59669834
109Chemical carcinogenesis_Homo sapiens_hsa052040.59636192
110GnRH signaling pathway_Homo sapiens_hsa049120.58675721
111Ovarian steroidogenesis_Homo sapiens_hsa049130.57808407
112VEGF signaling pathway_Homo sapiens_hsa043700.56098879
113Notch signaling pathway_Homo sapiens_hsa043300.55870551
114One carbon pool by folate_Homo sapiens_hsa006700.55355073
115Gastric acid secretion_Homo sapiens_hsa049710.55145766
116Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.54562668
117Insulin secretion_Homo sapiens_hsa049110.53617666
118Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53018431
119Lysine degradation_Homo sapiens_hsa003100.51488479
120MAPK signaling pathway_Homo sapiens_hsa040100.48852599
121Retinol metabolism_Homo sapiens_hsa008300.48805167
122Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48786436
123Viral myocarditis_Homo sapiens_hsa054160.48158363
124Pyrimidine metabolism_Homo sapiens_hsa002400.48093519
125Ras signaling pathway_Homo sapiens_hsa040140.47595272
126Estrogen signaling pathway_Homo sapiens_hsa049150.47074440
127Dorso-ventral axis formation_Homo sapiens_hsa043200.46934288
128Aldosterone synthesis and secretion_Homo sapiens_hsa049250.46582729
129Endocytosis_Homo sapiens_hsa041440.46437870
130Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45794976
131Glioma_Homo sapiens_hsa052140.45468667
132Arachidonic acid metabolism_Homo sapiens_hsa005900.44004912
133Sphingolipid signaling pathway_Homo sapiens_hsa040710.43208928
134TGF-beta signaling pathway_Homo sapiens_hsa043500.42962477
135Renin secretion_Homo sapiens_hsa049240.42717626
136Cell cycle_Homo sapiens_hsa041100.39234721
137Rap1 signaling pathway_Homo sapiens_hsa040150.38594717
138Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.38418974
139Basal transcription factors_Homo sapiens_hsa030220.37697384
140Salivary secretion_Homo sapiens_hsa049700.37578498
141Fatty acid biosynthesis_Homo sapiens_hsa000610.37228331
142Pathways in cancer_Homo sapiens_hsa052000.36837654
143Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.35773717
144Olfactory transduction_Homo sapiens_hsa047400.35286337
145Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34207056
146DNA replication_Homo sapiens_hsa030300.33911378
147AMPK signaling pathway_Homo sapiens_hsa041520.32119010
148Choline metabolism in cancer_Homo sapiens_hsa052310.32116771
149Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.31294869

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »