MITF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. It regulates the differentiation and development of melanocytes retinal pigment epithelium and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1developmental pigmentation (GO:0048066)5.84059253
2tyrosine metabolic process (GO:0006570)5.55191795
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.54220478
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.48620312
5positive regulation by organism of defense response of other organism involved in symbiotic interact5.48620312
6modulation by symbiont of host immune response (GO:0052553)5.48620312
7positive regulation by symbiont of host defense response (GO:0052509)5.48620312
8modulation by symbiont of host defense response (GO:0052031)5.48620312
9modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.48620312
10cellular response to thyroid hormone stimulus (GO:0097067)5.23500897
11regulation of integrin-mediated signaling pathway (GO:2001044)5.00466996
12endosome to pigment granule transport (GO:0043485)4.94118785
13endosome to melanosome transport (GO:0035646)4.94118785
14secondary metabolic process (GO:0019748)4.84678162
15phenol-containing compound biosynthetic process (GO:0046189)4.79312680
16positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.70822644
17positive regulation of interferon-alpha production (GO:0032727)4.48424803
18response to peptidoglycan (GO:0032494)4.48057159
19neutrophil activation involved in immune response (GO:0002283)4.46781580
20response to thyroid hormone (GO:0097066)4.30356169
21macrophage activation involved in immune response (GO:0002281)4.29846303
22regulation of interferon-alpha production (GO:0032647)4.23036847
23regulation of early endosome to late endosome transport (GO:2000641)4.07902154
24regulation of interferon-beta biosynthetic process (GO:0045357)4.05153401
25muscle filament sliding (GO:0030049)4.03110133
26actin-myosin filament sliding (GO:0033275)4.03110133
27response to epinephrine (GO:0071871)3.87330712
28hydrogen peroxide biosynthetic process (GO:0050665)3.81355552
29positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.81192144
30sarcoplasmic reticulum calcium ion transport (GO:0070296)3.80522049
31positive regulation of receptor recycling (GO:0001921)3.80151604
32melanosome organization (GO:0032438)3.77744568
33positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.73801839
34cGMP-mediated signaling (GO:0019934)3.72245350
35detection of molecule of bacterial origin (GO:0032490)3.71356543
36regulation of skeletal muscle contraction (GO:0014819)3.66971647
37myofibril assembly (GO:0030239)3.57937929
38response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.57699912
39response to host immune response (GO:0052572)3.57699912
40regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.56683631
41regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.55529287
42respiratory burst (GO:0045730)3.55465189
43* neuroepithelial cell differentiation (GO:0060563)3.54680229
44pigment granule organization (GO:0048753)3.54088589
45actin-mediated cell contraction (GO:0070252)3.51620798
46sarcomere organization (GO:0045214)3.48927748
47lipopolysaccharide-mediated signaling pathway (GO:0031663)3.48200161
48ketone body metabolic process (GO:1902224)3.48182466
49production of molecular mediator involved in inflammatory response (GO:0002532)3.47825954
50negative regulation of hydrogen peroxide-induced cell death (GO:1903206)3.42730660
51glycosphingolipid catabolic process (GO:0046479)3.42728221
52negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.40100486
53reactive oxygen species biosynthetic process (GO:1903409)3.34886487
54positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.34859043
55galactose catabolic process (GO:0019388)3.33676207
56regulation of mononuclear cell migration (GO:0071675)3.33504137
57microglial cell activation (GO:0001774)3.32380396
58response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.32102747
59regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.29534677
60muscle cell cellular homeostasis (GO:0046716)3.26796655
61superoxide anion generation (GO:0042554)3.26521099
62positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.26258775
63positive regulation of chemokine biosynthetic process (GO:0045080)3.24305739
64positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.23316838
65immunoglobulin mediated immune response (GO:0016064)3.23058756
66pigmentation (GO:0043473)3.22314685
67macrophage activation (GO:0042116)3.20145791
68cellular response to reactive nitrogen species (GO:1902170)3.20086652
69regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.18515004
70galactose metabolic process (GO:0006012)3.17780491
71oligosaccharide catabolic process (GO:0009313)3.15368204
72response to host (GO:0075136)3.14414512
73response to host defenses (GO:0052200)3.14414512
74response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.14414512
75positive regulation of macrophage cytokine production (GO:0060907)3.13777319
76regulation of relaxation of muscle (GO:1901077)3.13373793
77positive regulation of interferon-beta production (GO:0032728)3.13291168
78calcium-mediated signaling using intracellular calcium source (GO:0035584)3.13054978
79Rap protein signal transduction (GO:0032486)3.12372750
80pigment biosynthetic process (GO:0046148)3.10656186
81negative regulation of interleukin-17 production (GO:0032700)3.10178760
82cardiac myofibril assembly (GO:0055003)3.07902341
83T-helper 1 type immune response (GO:0042088)3.07805185
84negative regulation of response to reactive oxygen species (GO:1901032)3.05230062
85regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.02911143
86regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.01907065
87glycolipid catabolic process (GO:0019377)3.01578068
88response to muscle activity (GO:0014850)3.01519440
89positive regulation of cellular amide metabolic process (GO:0034250)3.00767959
90response to muramyl dipeptide (GO:0032495)2.99236641
91keratan sulfate catabolic process (GO:0042340)2.97908372
92natural killer cell mediated cytotoxicity (GO:0042267)2.97776677
93natural killer cell mediated immunity (GO:0002228)2.97776677
94myeloid cell activation involved in immune response (GO:0002275)2.97352021
95I-kappaB phosphorylation (GO:0007252)2.95758408
96* pigment cell differentiation (GO:0050931)2.94800300
97cellular response to zinc ion (GO:0071294)2.94406068
98negative regulation of protein localization to plasma membrane (GO:1903077)2.94025942
99heart process (GO:0003015)2.92806570
100heart contraction (GO:0060047)2.92806570
101actin filament-based movement (GO:0030048)2.92219873
102regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.90639687
103regulation of hydrogen peroxide-induced cell death (GO:1903205)2.90046504
104granulocyte activation (GO:0036230)2.86974720
105cellular response to epinephrine stimulus (GO:0071872)2.86725525
106low-density lipoprotein particle clearance (GO:0034383)2.82400221
107cardiac muscle contraction (GO:0060048)2.81546959
108actomyosin structure organization (GO:0031032)2.79808769
109positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.75678557
110striated muscle contraction (GO:0006941)2.74302714
111neutrophil activation (GO:0042119)2.73687655
112regulation of cholesterol storage (GO:0010885)2.73493700
113ceramide catabolic process (GO:0046514)2.73297196
114apoptotic cell clearance (GO:0043277)2.70395353
115cardiac muscle hypertrophy (GO:0003300)2.67923620
116positive regulation of chemokine production (GO:0032722)2.67583041
117regulation of superoxide metabolic process (GO:0090322)2.67526160
118platelet dense granule organization (GO:0060155)2.66889851
119* melanocyte differentiation (GO:0030318)2.66851935
120pigment metabolic process (GO:0042440)2.66531418
121fibroblast migration (GO:0010761)2.66258681
122response to interferon-alpha (GO:0035455)2.65794099
123positive regulation of mast cell degranulation (GO:0043306)2.64267342
124positive regulation of mast cell activation involved in immune response (GO:0033008)2.64267342
125positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.63417808
126intracellular pH reduction (GO:0051452)2.63415912
127negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.63094890
128cardiac muscle cell development (GO:0055013)2.60062457
129response to inactivity (GO:0014854)2.60045381
130positive regulation of mast cell activation (GO:0033005)2.59172916
131cell migration involved in heart development (GO:0060973)2.57593211
132regulation of actin filament-based movement (GO:1903115)2.57247031
133negative regulation of protein localization to cell surface (GO:2000009)2.57138279
134type I interferon signaling pathway (GO:0060337)2.57059985
135cellular response to type I interferon (GO:0071357)2.57059985
136positive regulation of heat generation (GO:0031652)2.56852312
137regulation of macrophage cytokine production (GO:0010935)2.56717017
138negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.56395958
139relaxation of cardiac muscle (GO:0055119)2.56391396
140positive regulation of toll-like receptor signaling pathway (GO:0034123)2.54859657
141response to type I interferon (GO:0034340)2.54800140
142regulation of receptor recycling (GO:0001919)2.53842068
143striated muscle hypertrophy (GO:0014897)2.53606374
144cellular response to interferon-alpha (GO:0035457)2.53453682
145pinocytosis (GO:0006907)2.51340900
146regulation of superoxide anion generation (GO:0032928)2.51111960
147negative regulation of lipid storage (GO:0010888)2.50929440
148phagocytosis, recognition (GO:0006910)2.50771168
149barbed-end actin filament capping (GO:0051016)2.50688329
150regulation of chemokine biosynthetic process (GO:0045073)2.50384628
151positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.49957148
152eosinophil chemotaxis (GO:0048245)2.49567885
153semaphorin-plexin signaling pathway (GO:0071526)2.48840177
154detection of external biotic stimulus (GO:0098581)2.48573280
155regulation of interleukin-8 biosynthetic process (GO:0045414)2.47910887
156cellular response to arsenic-containing substance (GO:0071243)2.46931164
157hyaluronan catabolic process (GO:0030214)2.46560518
158regulation of macrophage derived foam cell differentiation (GO:0010743)2.46065190
159regulation of lipoprotein metabolic process (GO:0050746)2.43621042
160nerve growth factor signaling pathway (GO:0038180)2.43274231
161regulation of endothelial cell chemotaxis (GO:2001026)2.43089920
162positive regulation of interleukin-12 production (GO:0032735)2.42893511
163positive regulation of interleukin-6 production (GO:0032755)2.41544596
164phagosome maturation (GO:0090382)2.41127338
165endothelial cell morphogenesis (GO:0001886)2.40143695
166relaxation of muscle (GO:0090075)2.39876096
167basement membrane organization (GO:0071711)2.39771376
168cellular extravasation (GO:0045123)2.39254123
169* osteoclast differentiation (GO:0030316)2.37413826
170muscle hypertrophy (GO:0014896)2.37086706
171cardiac cell development (GO:0055006)2.35654712
172aromatic amino acid family metabolic process (GO:0009072)2.31769523
173tricarboxylic acid cycle (GO:0006099)2.29756294
174skeletal muscle adaptation (GO:0043501)2.27025540
175pH reduction (GO:0045851)2.26169804
176regulation of membrane protein ectodomain proteolysis (GO:0051043)2.24655876
177antigen processing and presentation via MHC class Ib (GO:0002475)2.23978066
178melanin biosynthetic process (GO:0042438)15.3191838
179melanin metabolic process (GO:0006582)13.8183207
180secondary metabolite biosynthetic process (GO:0044550)12.6199425

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.45625092
2IRF8_21731497_ChIP-ChIP_J774_Mouse6.00255236
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.81464228
4* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse4.19301596
5IRF8_27001747_Chip-Seq_BMDM_Mouse4.12717465
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.92843235
7NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.47722269
8* IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.19103978
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.75956025
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.75144404
11RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.68943271
12* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.54356264
13CDX2_19796622_ChIP-Seq_MESCs_Mouse2.47545487
14* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.45268621
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.40043902
16PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.32284565
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.20639127
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.12472327
19RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.11766385
20VDR_24787735_ChIP-Seq_THP-1_Human2.02662064
21NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.01001236
22GATA2_21666600_ChIP-Seq_HMVEC_Human1.98286976
23STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.86795310
24BRD4_27068464_Chip-Seq_AML-cells_Mouse1.85804790
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.82297435
26PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.81942486
27* MITF_21258399_ChIP-Seq_MELANOMA_Human1.80629848
28PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.77604010
29PU_27001747_Chip-Seq_BMDM_Mouse1.77242521
30STAT4_19710469_ChIP-ChIP_TH1__Mouse1.72847372
31STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.70304143
32CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.66796592
33PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.59937638
34CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.59584755
35NRF2_20460467_ChIP-Seq_MEFs_Mouse1.57864687
36NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.57864687
37SPI1_23127762_ChIP-Seq_K562_Human1.57545718
38SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.56850293
39SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.53561132
40AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.52997229
41GATA4_21415370_ChIP-Seq_HL-1_Mouse1.51549651
42THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.50670848
43CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.50193246
44CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.47807839
45TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.47404456
46EGR1_19032775_ChIP-ChIP_M12_Human1.47003158
47* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.44998060
48CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.39931140
49EZH2_27294783_Chip-Seq_NPCs_Mouse1.39733563
50LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.38214467
51LXR_22158963_ChIP-Seq_LIVER_Mouse1.38012254
52* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37739721
53NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.36040954
54CJUN_26792858_Chip-Seq_BT549_Human1.35865128
55MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.34805066
56VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.34583358
57* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.34134113
58EP300_21415370_ChIP-Seq_HL-1_Mouse1.32673967
59CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.32391575
60BRD4_25478319_ChIP-Seq_HGPS_Human1.32138137
61TRIM28_21343339_ChIP-Seq_HEK293_Human1.31631960
62* SPI1_23547873_ChIP-Seq_NB4_Human1.31041189
63CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.30872992
64PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.28775826
65PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.28738969
66CTNNB1_20460455_ChIP-Seq_HCT116_Human1.28087695
67TP53_16413492_ChIP-PET_HCT116_Human1.25481464
68ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.22131877
69CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.21213100
70NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.18156903
71RUNX_20019798_ChIP-Seq_JUKART_Human1.18009799
72* VDR_24763502_ChIP-Seq_THP-1_Human1.17972704
73TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.15121329
74CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14521884
75PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.14331917
76PPAR_26484153_Chip-Seq_NCI-H1993_Human1.14003507
77CRX_20693478_ChIP-Seq_RETINA_Mouse1.13211564
78* TBX20_22080862_ChIP-Seq_HEART_Mouse1.13173321
79* TBX20_22328084_ChIP-Seq_HEART_Mouse1.13173321
80* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.12538128
81SCL_19346495_ChIP-Seq_HPC-7_Human1.12443918
82SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.11671193
83GATA1_19941826_ChIP-Seq_K562_Human1.11226752
84CLOCK_20551151_ChIP-Seq_293T_Human1.10945005
85SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10762685
86TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.10716500
87* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10549643
88SALL4_18804426_ChIP-ChIP_XEN_Mouse1.08406683
89TFEB_21752829_ChIP-Seq_HELA_Human1.08272422
90SMAD_19615063_ChIP-ChIP_OVARY_Human1.08069229
91GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07981907
92* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.07310853
93FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.07021587
94SOX2_20726797_ChIP-Seq_SW620_Human1.06578858
95TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.06426114
96GATA3_26560356_Chip-Seq_TH2_Human1.05935873
97CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04745359
98* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03983749
99ESR1_21235772_ChIP-Seq_MCF-7_Human1.03912612
100NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.03704305
101CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02972079
102NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.02961029
103E2F1_18555785_Chip-Seq_ESCs_Mouse1.02877526
104* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.01788564
105JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01259718
106FOXO3_23340844_ChIP-Seq_DLD1_Human1.01233632
107PIAS1_25552417_ChIP-Seq_VCAP_Human0.99966505
108HIF1A_21447827_ChIP-Seq_MCF-7_Human0.99831813
109* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.98945009
110* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98873472
111NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98858492
112RUNX1_22412390_ChIP-Seq_EML_Mouse0.98850070
113JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98166883
114* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.97119275
115* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.97119275
116OCT4_21477851_ChIP-Seq_ESCs_Mouse0.96071006
117* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95722823
118PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.95242143
119* SMAD4_21799915_ChIP-Seq_A2780_Human0.95237395
120RARG_19884340_ChIP-ChIP_MEFs_Mouse0.94917503
121TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.93543466
122NFE2_27457419_Chip-Seq_LIVER_Mouse0.93292734
123MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.93007547
124SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91125022
125GATA3_27048872_Chip-Seq_THYMUS_Human0.88666676
126SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.87998070
127GATA1_22025678_ChIP-Seq_K562_Human0.87506776
128RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.86848181
129PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85243393
130MYB_26560356_Chip-Seq_TH2_Human0.84021261
131* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.81495092
132WT1_19549856_ChIP-ChIP_CCG9911_Human0.81092529
133TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.80494418
134ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.78889810
135TP63_23658742_ChIP-Seq_EP156T_Human0.78631097
136FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.77589308
137P63_26484246_Chip-Seq_KERATINOCYTES_Human0.76581030
138FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.76523551
139* GATA2_19941826_ChIP-Seq_K562_Human0.76284765
140RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.76142443
141* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75002115
142ESR1_20079471_ChIP-ChIP_T-47D_Human0.73994408

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0000372_irregular_coat_pigmentation7.97348937
2* MP0005171_absent_coat_pigmentation5.69974218
3MP0005257_abnormal_intraocular_pressure3.89860381
4* MP0005408_hypopigmentation3.62541604
5* MP0000371_diluted_coat_color3.53585423
6MP0005058_abnormal_lysosome_morphology2.91652293
7MP0000569_abnormal_digit_pigmentation2.83306087
8MP0001835_abnormal_antigen_presentation2.33452252
9* MP0005174_abnormal_tail_pigmentation2.31502263
10MP0004510_myositis2.24398135
11MP0006082_CNS_inflammation2.23582937
12MP0009785_altered_susceptibility_to2.07917998
13MP0002148_abnormal_hypersensitivity_rea2.07229928
14MP0003436_decreased_susceptibility_to2.04124478
15MP0005377_hearing/vestibular/ear_phenot2.02646845
16MP0003878_abnormal_ear_physiology2.02646845
17* MP0002095_abnormal_skin_pigmentation1.97496566
18* MP0002419_abnormal_innate_immunity1.94759646
19* MP0001324_abnormal_eye_pigmentation1.93482423
20MP0005409_darkened_coat_color1.92203263
21MP0004084_abnormal_cardiac_muscle1.85984563
22* MP0002075_abnormal_coat/hair_pigmentati1.83847664
23* MP0002877_abnormal_melanocyte_morpholog1.83396980
24MP0003172_abnormal_lysosome_physiology1.82070153
25MP0005075_abnormal_melanosome_morpholog1.80104017
26MP0003303_peritoneal_inflammation1.79888507
27MP0003191_abnormal_cellular_cholesterol1.70882052
28MP0005000_abnormal_immune_tolerance1.69923063
29MP0003950_abnormal_plasma_membrane1.65036080
30MP0003828_pulmonary_edema1.61358025
31MP0005025_abnormal_response_to1.60937895
32MP0003705_abnormal_hypodermis_morpholog1.60132526
33MP0003724_increased_susceptibility_to1.59769005
34* MP0004381_abnormal_hair_follicle1.59683055
35MP0000751_myopathy1.59248085
36MP0008438_abnormal_cutaneous_collagen1.59165998
37MP0003646_muscle_fatigue1.58801800
38MP0000343_altered_response_to1.54914558
39MP0003806_abnormal_nucleotide_metabolis1.52480292
40MP0004233_abnormal_muscle_weight1.46329437
41* MP0001186_pigmentation_phenotype1.44430410
42* MP0000015_abnormal_ear_pigmentation1.43445840
43MP0003566_abnormal_cell_adhesion1.37682291
44MP0009840_abnormal_foam_cell1.37569256
45MP0005387_immune_system_phenotype1.33003287
46MP0001790_abnormal_immune_system1.33003287
47MP0005670_abnormal_white_adipose1.32749787
48MP0003690_abnormal_glial_cell1.29268718
49MP0003448_altered_tumor_morphology1.29052293
50* MP0002452_abnormal_antigen_presenting1.28697565
51MP0002102_abnormal_ear_morphology1.28459795
52MP0002090_abnormal_vision1.26316678
53MP0000747_muscle_weakness1.24197762
54* MP0003136_yellow_coat_color1.23185968
55MP0001533_abnormal_skeleton_physiology1.20544757
56MP0008775_abnormal_heart_ventricle1.20266874
57MP0002269_muscular_atrophy1.17418167
58MP0004036_abnormal_muscle_relaxation1.14761528
59MP0002723_abnormal_immune_serum1.14316265
60MP0005164_abnormal_response_to1.13768047
61MP0003453_abnormal_keratinocyte_physiol1.12477207
62MP0005464_abnormal_platelet_physiology1.11296275
63MP0000685_abnormal_immune_system1.08810998
64MP0005620_abnormal_muscle_contractility1.08762057
65MP0002972_abnormal_cardiac_muscle1.08599777
66* MP0005197_abnormal_uvea_morphology1.06543715
67MP0004947_skin_inflammation1.05558307
68MP0003075_altered_response_to1.01256401
69MP0000920_abnormal_myelination1.00697392
70MP0001800_abnormal_humoral_immune1.00574311
71MP0005671_abnormal_response_to0.98551190
72* MP0001819_abnormal_immune_cell0.97770303
73MP0004130_abnormal_muscle_cell0.96031363
74* MP0002420_abnormal_adaptive_immunity0.95257932
75MP0010307_abnormal_tumor_latency0.94734208
76* MP0002998_abnormal_bone_remodeling0.94643528
77MP0005165_increased_susceptibility_to0.92372935
78MP0009764_decreased_sensitivity_to0.92371359
79MP0000733_abnormal_muscle_development0.92050799
80MP0000604_amyloidosis0.91416860
81MP0001845_abnormal_inflammatory_respons0.90168709
82MP0004272_abnormal_basement_membrane0.89655952
83MP0005451_abnormal_body_composition0.89510383
84MP0002332_abnormal_exercise_endurance0.89169137
85MP0001544_abnormal_cardiovascular_syste0.89013493
86MP0005385_cardiovascular_system_phenoty0.89013493
87MP0000749_muscle_degeneration0.88132587
88MP0008260_abnormal_autophagy0.86997789
89MP0002837_dystrophic_cardiac_calcinosis0.86936575
90MP0005167_abnormal_blood-brain_barrier0.86079343
91MP0000759_abnormal_skeletal_muscle0.85844988
92MP0004087_abnormal_muscle_fiber0.85415263
93MP0003091_abnormal_cell_migration0.85090233
94MP0006138_congestive_heart_failure0.84834871
95MP0008004_abnormal_stomach_pH0.84684182
96MP0005330_cardiomyopathy0.84543029
97MP0008469_abnormal_protein_level0.83212545
98MP0009278_abnormal_bone_marrow0.83002896
99MP0001853_heart_inflammation0.82393595
100MP0004215_abnormal_myocardial_fiber0.81779602
101MP0002405_respiratory_system_inflammati0.81052681
102MP0010630_abnormal_cardiac_muscle0.80879827
103MP0004145_abnormal_muscle_electrophysio0.77976853
104MP0005166_decreased_susceptibility_to0.77753069
105MP0006054_spinal_hemorrhage0.77131643
106MP0005023_abnormal_wound_healing0.75587198
107MP0004885_abnormal_endolymph0.73846398
108MP0001958_emphysema0.72685971
109MP0004484_altered_response_of0.71800926
110* MP0002938_white_spotting0.71526024
111MP0003567_abnormal_fetal_cardiomyocyte0.70140997
112MP0003186_abnormal_redox_activity0.68865660
113MP0005369_muscle_phenotype0.67068888
114MP0000858_altered_metastatic_potential0.66520012
115MP0003221_abnormal_cardiomyocyte_apopto0.65893963
116MP0002106_abnormal_muscle_physiology0.65729611
117MP0006036_abnormal_mitochondrial_physio0.64845429
118MP0002006_tumorigenesis0.63637657
119MP0000767_abnormal_smooth_muscle0.63169378
120MP0001851_eye_inflammation0.56968912
121MP0003279_aneurysm0.56822654
122MP0003011_delayed_dark_adaptation0.56028758
123MP0005275_abnormal_skin_tensile0.55433038
124MP0003656_abnormal_erythrocyte_physiolo0.55154577
125* MP0005193_abnormal_anterior_eye0.53286761
126MP0000750_abnormal_muscle_regeneration0.53023716
127* MP0005253_abnormal_eye_physiology0.52165876
128MP0003300_gastrointestinal_ulcer0.49948489
129MP0003137_abnormal_impulse_conducting0.49607142
130MP0010234_abnormal_vibrissa_follicle0.49185706
131MP0001661_extended_life_span0.45602968
132MP0003634_abnormal_glial_cell0.41945334
133MP0000465_gastrointestinal_hemorrhage0.41712710
134MP0000358_abnormal_cell_content/0.41629654
135MP0002971_abnormal_brown_adipose0.39891705
136MP0002896_abnormal_bone_mineralization0.38304467
137* MP0000367_abnormal_coat/_hair0.37136191

Predicted human phenotypes

RankGene SetZ-score
1Ocular albinism (HP:0001107)6.14082182
2* Aplasia/Hypoplasia of the macula (HP:0008059)6.07117314
3Recurrent abscess formation (HP:0002722)5.74692709
4* Patchy hypopigmentation of hair (HP:0011365)5.67620901
5* Aplasia/Hypoplasia affecting the retina (HP:0008061)5.61664982
6Eczematoid dermatitis (HP:0000976)5.37850400
7* Blue irides (HP:0000635)5.37628587
8Recurrent bacterial skin infections (HP:0005406)5.23746252
9Iris hypopigmentation (HP:0007730)5.14294057
10Recurrent gram-negative bacterial infections (HP:0005420)4.67743585
11Subacute progressive viral hepatitis (HP:0006572)4.59404649
12* Hypoplasia of the fovea (HP:0007750)4.50880269
13* Aplasia/Hypoplasia of the fovea (HP:0008060)4.50880269
14Abnormal auditory evoked potentials (HP:0006958)4.35781081
15Hypopigmentation of the fundus (HP:0007894)4.30316034
16Abnormality of macrophages (HP:0004311)4.29212842
17Systemic lupus erythematosus (HP:0002725)4.13097481
18Nemaline bodies (HP:0003798)4.08332619
19Muscle fiber inclusion bodies (HP:0100299)3.98247852
20Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.95438172
21Asymmetric septal hypertrophy (HP:0001670)3.84041995
22* Abnormality of the fovea (HP:0000493)3.70557657
23Increased cerebral lipofuscin (HP:0011813)3.59373368
24Exercise-induced muscle cramps (HP:0003710)3.56020153
25Orchitis (HP:0100796)3.51840731
26* Generalized hypopigmentation (HP:0007513)3.42737268
27Frequent falls (HP:0002359)3.39298659
28Vacuolated lymphocytes (HP:0001922)3.39284621
29Retrobulbar optic neuritis (HP:0100654)3.36291178
30Optic neuritis (HP:0100653)3.36291178
31Mediastinal lymphadenopathy (HP:0100721)3.31626369
32Axonal loss (HP:0003447)3.27964230
33Increased neuronal autofluorescent lipopigment (HP:0002074)3.26145740
34Dysostosis multiplex (HP:0000943)3.24068037
35Type 1 muscle fiber predominance (HP:0003803)3.16846580
36Myositis (HP:0100614)3.12880571
37Gingivitis (HP:0000230)3.09660298
38Mucopolysacchariduria (HP:0008155)3.00865692
39Urinary glycosaminoglycan excretion (HP:0003541)3.00865692
40* Albinism (HP:0001022)3.00181254
41Exercise-induced myalgia (HP:0003738)2.96995172
42Abnormality of glycosphingolipid metabolism (HP:0004343)2.92996591
43Abnormality of glycolipid metabolism (HP:0010969)2.92996591
44Abnormality of liposaccharide metabolism (HP:0010968)2.92996591
45Distal lower limb muscle weakness (HP:0009053)2.84094120
46Recurrent skin infections (HP:0001581)2.82779419
47Micronodular cirrhosis (HP:0001413)2.82028670
48Abnormality of polysaccharide metabolism (HP:0011012)2.80674139
49Abnormality of glycosaminoglycan metabolism (HP:0004371)2.80674139
50Abnormality of mucopolysaccharide metabolism (HP:0011020)2.80674139
51Bundle branch block (HP:0011710)2.76655221
52Viral hepatitis (HP:0006562)2.72765398
53Abnormality of the calf musculature (HP:0001430)2.64022701
54Thick nail (HP:0001805)2.62110752
55Stomatitis (HP:0010280)2.61563319
56Elevated erythrocyte sedimentation rate (HP:0003565)2.55762915
57Muscle fiber splitting (HP:0003555)2.54151653
58Myoglobinuria (HP:0002913)2.53679067
59Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.52459589
60Vertebral compression fractures (HP:0002953)2.51096448
61Rhabdomyolysis (HP:0003201)2.50533682
62Increased connective tissue (HP:0009025)2.49256141
63Freckling (HP:0001480)2.43790374
64Sudden death (HP:0001699)2.42662728
65Cholecystitis (HP:0001082)2.42582297
66Abnormal gallbladder physiology (HP:0012438)2.42582297
67Obstructive lung disease (HP:0006536)2.42196126
68Chronic obstructive pulmonary disease (HP:0006510)2.42196126
69Loss of speech (HP:0002371)2.41166738
70Hematochezia (HP:0002573)2.40158576
71Generalized hypopigmentation of hair (HP:0011358)2.37597685
72Osteolytic defects of the phalanges of the hand (HP:0009771)2.36406387
73Osteolytic defects of the hand bones (HP:0009699)2.36406387
74* Premature graying of hair (HP:0002216)2.31693975
75Arterial thrombosis (HP:0004420)2.27952657
76Centrally nucleated skeletal muscle fibers (HP:0003687)2.25769989
77Conjunctival telangiectasia (HP:0000524)2.24695206
78Autoimmune thrombocytopenia (HP:0001973)2.24483951
79Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.23906652
80Spontaneous hematomas (HP:0007420)2.22722300
81Ventricular tachycardia (HP:0004756)2.17862149
82Pulmonary infiltrates (HP:0002113)2.17558868
83* Heterochromia iridis (HP:0001100)2.16897311
84Dilated cardiomyopathy (HP:0001644)2.16520654
85Petechiae (HP:0000967)2.15908261
86Prostate neoplasm (HP:0100787)2.14598781
87Lipoatrophy (HP:0100578)2.13861900
88Tetraparesis (HP:0002273)2.13680663
89Urticaria (HP:0001025)2.13530992
90Keratoconjunctivitis sicca (HP:0001097)2.13121655
91Disinhibition (HP:0000734)2.12654542
92Myocardial infarction (HP:0001658)2.12587572
93Neck muscle weakness (HP:0000467)2.11866317
94Vasculitis (HP:0002633)2.11116124
95Recurrent fungal infections (HP:0002841)2.09237814
96Muscle hypertrophy of the lower extremities (HP:0008968)2.09170445
97Pustule (HP:0200039)2.09009131
98Skin nodule (HP:0200036)2.08595148
99Basal ganglia calcification (HP:0002135)2.06140230
100Abnormality of the left ventricular outflow tract (HP:0011103)2.05930554
101Subaortic stenosis (HP:0001682)2.05930554
102Increased IgM level (HP:0003496)2.02362274
103Cerebral inclusion bodies (HP:0100314)2.01761770
104Scapular winging (HP:0003691)2.00190388
105Hepatosplenomegaly (HP:0001433)1.99053359
106Increased mean platelet volume (HP:0011877)1.98129652
107Hyporeflexia of lower limbs (HP:0002600)1.97376634
108Abnormality of vision evoked potentials (HP:0000649)1.96838041
109Glomerulonephritis (HP:0000099)1.96787640
110Hepatocellular carcinoma (HP:0001402)1.96384762
111Osteomyelitis (HP:0002754)1.96346209
112Esophageal neoplasm (HP:0100751)1.94932737
113Neoplasm of head and neck (HP:0012288)1.94932737
114Periodontitis (HP:0000704)1.93892403
115Cellulitis (HP:0100658)1.92492319
116Atrial fibrillation (HP:0005110)1.90138070
117Keratoconjunctivitis (HP:0001096)1.89411777
118Mucosal telangiectasiae (HP:0100579)1.88980345
119Calf muscle hypertrophy (HP:0008981)1.88698816
120Upper limb muscle weakness (HP:0003484)1.88434166
121Purpura (HP:0000979)1.88267764
122Abnormality of glycolysis (HP:0004366)1.87285880
123* White forelock (HP:0002211)1.86773072
124Abnormality of skeletal muscle fiber size (HP:0012084)1.86685417
125Spastic paraparesis (HP:0002313)1.86591800
126Cerebral aneurysm (HP:0004944)1.84995102
127* Hypoplasia of the iris (HP:0007676)1.84931614
128EMG: myopathic abnormalities (HP:0003458)1.82629849
129Distal lower limb amyotrophy (HP:0008944)1.80766658
130Peripheral demyelination (HP:0011096)1.80456224
131Epidermoid cyst (HP:0200040)1.79076529
132Conjunctival hamartoma (HP:0100780)1.79012032
133Pulmonary artery stenosis (HP:0004415)1.78498008
134Neurofibrillary tangles (HP:0002185)1.78208149
135Prolonged neonatal jaundice (HP:0006579)1.77375553
136Gingival bleeding (HP:0000225)1.75727124
137Bone pain (HP:0002653)1.75300484
138Nausea (HP:0002018)1.74811864
139Coarse hair (HP:0002208)1.74406890
140Abnormality of the vasculature of the conjunctiva (HP:0008054)1.73043728
141Increased variability in muscle fiber diameter (HP:0003557)1.73024941
142J-shaped sella turcica (HP:0002680)1.72264566
143Bulbar palsy (HP:0001283)1.68346066
144Decreased motor nerve conduction velocity (HP:0003431)1.68321383
145Abnormal atrioventricular conduction (HP:0005150)1.68179667
146Abnormal platelet volume (HP:0011876)1.65661249
147Distal arthrogryposis (HP:0005684)1.64997183
148Aortic aneurysm (HP:0004942)1.64319712
149Horizontal nystagmus (HP:0000666)1.62397814
150Paraparesis (HP:0002385)1.60478144
151Hypoalphalipoproteinemia (HP:0003233)1.59924887
152Tongue fasciculations (HP:0001308)1.58773271
153Primary atrial arrhythmia (HP:0001692)1.58748969
154Protrusio acetabuli (HP:0003179)1.58269438

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R8.98199761
2MET4.09680026
3BMX3.55181809
4PBK3.31481786
5RIPK42.86100771
6FER2.81318067
7MAP3K142.79747618
8BLK2.77491131
9PKN22.73149986
10TBK12.54115632
11MAP3K32.32199727
12TTN2.13570475
13ACVR1B1.98480317
14MAPKAPK31.85384969
15TYK21.84853452
16IRAK41.78043928
17EPHB11.68318554
18NEK11.65059842
19OBSCN1.64367511
20PIK3CG1.63804410
21IRAK31.63633753
22EPHA31.61658310
23NEK91.56903939
24PHKG11.52780135
25PHKG21.52780135
26TRIB31.52034959
27MAP3K131.49620316
28MAPK121.45066930
29LMTK21.42291850
30IKBKB1.39058419
31IKBKE1.38374792
32TRPM71.37288208
33JAK11.28957907
34STK41.24007948
35EIF2AK11.23199135
36TGFBR21.22130796
37PAK31.21072527
38CCNB11.18099403
39KIT1.14451906
40DMPK1.10112475
41MUSK1.05540226
42JAK31.05344236
43MAP2K11.02849934
44FGR1.02705270
45LIMK11.00129100
46BMPR20.99895096
47PTK2B0.97281316
48CSK0.94140889
49FGFR10.93702894
50GRK70.87089131
51MAP4K10.83685609
52MAPK70.83178616
53PAK40.81778585
54PTK20.81613004
55MYLK0.81112961
56ERBB40.81097018
57FRK0.79940711
58ERN10.79747848
59AKT20.76271129
60LATS20.76014448
61ABL20.75742363
62DDR20.75560691
63NEK60.75376237
64TRIM280.73810994
65SCYL20.73027217
66JAK20.71151389
67CDC42BPA0.68931681
68HCK0.68543523
69LYN0.67802367
70TXK0.65444816
71PAK10.65383023
72FLT30.64027388
73ZAK0.62885518
74MAP3K20.62344034
75ABL10.62220107
76CDK60.61638649
77CHUK0.61527513
78STK30.60533671
79PTK60.59084162
80WEE10.58295241
81CAMK2D0.57651818
82FGFR30.56680465
83ARAF0.56565994
84CSF1R0.56180868
85ZAP700.55940075
86ICK0.55889121
87MAPKAPK50.54901840
88PRKCD0.54416956
89LCK0.53784997
90PRKCQ0.53424871
91PDGFRB0.52895748
92STK240.52276174
93EGFR0.52227533
94PIK3CA0.52099561
95PAK60.50385050
96RIPK10.49328213
97KSR20.49220608
98CAMK1D0.49107423
99CSNK1A1L0.48982013
100PRKCH0.48925150
101PIM20.48600723
102TGFBR10.48152247
103EIF2AK30.48144637
104MAP3K50.48022931
105SIK30.47946712
106LRRK20.47931228
107MATK0.47856160
108PRKCE0.47726047
109ADRBK10.46011258
110PAK20.45866366
111CSNK1G20.45790283
112PDPK10.42847853
113PKN10.42786015
114CAMK2A0.41505329
115NME20.41199556
116BMPR1B0.41064152
117MAP3K60.40754667
118MOS0.39866167
119STK390.39102092
120ILK0.39006418
121CSNK1G30.39005698
122ERBB30.38524413
123PIM10.38392567
124MAP2K30.37555967
125YES10.37525809
126STK100.37296149
127PDK10.37132552
128MST40.36623140
129MAP3K110.36515744
130MELK0.35949884
131MAPK40.35617639
132PRKD10.34771658
133* GSK3A0.34527336
134PRKG20.34418500
135WNK10.33942394
136MAP3K100.33672799
137INSR0.33434442
138PLK20.33274213
139LATS10.32140080
140ROCK10.31711521
141SYK0.30380393
142IGF1R0.29290944
143CAMK2G0.29222718
144NUAK10.28998849
145SGK30.28836349
146CLK10.27925591
147IRAK10.27890816
148CSNK1G10.27719542
149PDGFRA0.27208093
150PDK20.26774077
151MAPKAPK20.26742747
152FYN0.25998218
153PRPF4B0.25659761
154EIF2AK20.25308585
155PRKAA20.24873040

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.00364858
2Leishmaniasis_Homo sapiens_hsa051402.87122303
3Malaria_Homo sapiens_hsa051442.79685824
4Glycosaminoglycan degradation_Homo sapiens_hsa005312.78126950
5Toll-like receptor signaling pathway_Homo sapiens_hsa046202.70076571
6Tyrosine metabolism_Homo sapiens_hsa003502.49341309
7Lysosome_Homo sapiens_hsa041422.46732885
8Legionellosis_Homo sapiens_hsa051342.27913109
9Rheumatoid arthritis_Homo sapiens_hsa053232.26756055
10Graft-versus-host disease_Homo sapiens_hsa053322.25767437
11Pentose phosphate pathway_Homo sapiens_hsa000302.21652702
12Tuberculosis_Homo sapiens_hsa051522.16865774
13* Osteoclast differentiation_Homo sapiens_hsa043802.16631418
14Phagosome_Homo sapiens_hsa041452.09783918
15Pertussis_Homo sapiens_hsa051332.06427300
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.94240407
17Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.82037650
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.79936396
19Allograft rejection_Homo sapiens_hsa053301.79051248
20Salmonella infection_Homo sapiens_hsa051321.71242010
21Measles_Homo sapiens_hsa051621.69591001
22ECM-receptor interaction_Homo sapiens_hsa045121.62742795
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.58824337
24Other glycan degradation_Homo sapiens_hsa005111.58160175
25Glutathione metabolism_Homo sapiens_hsa004801.56442742
26Asthma_Homo sapiens_hsa053101.56098457
27Viral myocarditis_Homo sapiens_hsa054161.46307230
28TNF signaling pathway_Homo sapiens_hsa046681.45886718
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.45746461
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.45335557
31Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.44885768
32Primary bile acid biosynthesis_Homo sapiens_hsa001201.42104592
33Toxoplasmosis_Homo sapiens_hsa051451.41462612
34Influenza A_Homo sapiens_hsa051641.41225764
35Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.39175309
36PPAR signaling pathway_Homo sapiens_hsa033201.36870246
37Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.36393988
38Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.31120006
39Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.24337493
40Type I diabetes mellitus_Homo sapiens_hsa049401.20980380
41B cell receptor signaling pathway_Homo sapiens_hsa046621.20645213
42Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.20345386
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.19442745
44Circadian rhythm_Homo sapiens_hsa047101.17628949
45Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.16740524
46Collecting duct acid secretion_Homo sapiens_hsa049661.16122944
47Fatty acid elongation_Homo sapiens_hsa000621.15964534
48Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.13638099
49Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.13106017
502-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.11837461
51Fructose and mannose metabolism_Homo sapiens_hsa000511.09811130
52Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.08942731
53Apoptosis_Homo sapiens_hsa042101.06462085
54Amoebiasis_Homo sapiens_hsa051461.05224196
55Carbon metabolism_Homo sapiens_hsa012001.04733666
56Hematopoietic cell lineage_Homo sapiens_hsa046401.02250145
57Dilated cardiomyopathy_Homo sapiens_hsa054141.01871017
58Sulfur metabolism_Homo sapiens_hsa009201.00936607
59Chemokine signaling pathway_Homo sapiens_hsa040621.00841887
60African trypanosomiasis_Homo sapiens_hsa051430.97120134
61HIF-1 signaling pathway_Homo sapiens_hsa040660.96744133
62cGMP-PKG signaling pathway_Homo sapiens_hsa040220.94945757
63Renal cell carcinoma_Homo sapiens_hsa052110.93793241
64Herpes simplex infection_Homo sapiens_hsa051680.92637852
65Leukocyte transendothelial migration_Homo sapiens_hsa046700.90256842
66Shigellosis_Homo sapiens_hsa051310.89729779
67ABC transporters_Homo sapiens_hsa020100.88864970
68Intestinal immune network for IgA production_Homo sapiens_hsa046720.88571461
69Propanoate metabolism_Homo sapiens_hsa006400.87385355
70Galactose metabolism_Homo sapiens_hsa000520.86792306
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.86409271
72Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.84777242
73Hepatitis B_Homo sapiens_hsa051610.84714717
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.83353553
75AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.83158223
76Nitrogen metabolism_Homo sapiens_hsa009100.80106949
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.80056741
78Complement and coagulation cascades_Homo sapiens_hsa046100.78927958
79Pyruvate metabolism_Homo sapiens_hsa006200.77877927
80Autoimmune thyroid disease_Homo sapiens_hsa053200.77357500
81Jak-STAT signaling pathway_Homo sapiens_hsa046300.77110385
82Central carbon metabolism in cancer_Homo sapiens_hsa052300.76004402
83Adherens junction_Homo sapiens_hsa045200.73484669
84Insulin signaling pathway_Homo sapiens_hsa049100.73464340
85Hepatitis C_Homo sapiens_hsa051600.72157991
86Sphingolipid metabolism_Homo sapiens_hsa006000.71107203
87Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.69629011
88SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69448674
89Prion diseases_Homo sapiens_hsa050200.67731824
90Inositol phosphate metabolism_Homo sapiens_hsa005620.65017250
91Focal adhesion_Homo sapiens_hsa045100.64878675
92Calcium signaling pathway_Homo sapiens_hsa040200.64404544
93Proteoglycans in cancer_Homo sapiens_hsa052050.63544379
94Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63258636
95Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.62287098
96Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58898946
97Platelet activation_Homo sapiens_hsa046110.58473559
98Starch and sucrose metabolism_Homo sapiens_hsa005000.57991167
99Chronic myeloid leukemia_Homo sapiens_hsa052200.57208442
100Fatty acid degradation_Homo sapiens_hsa000710.57025059
101Steroid biosynthesis_Homo sapiens_hsa001000.56546159
102Prostate cancer_Homo sapiens_hsa052150.56182405
103Cardiac muscle contraction_Homo sapiens_hsa042600.55370211
104Ovarian steroidogenesis_Homo sapiens_hsa049130.53718142
105Histidine metabolism_Homo sapiens_hsa003400.52967752
106Vibrio cholerae infection_Homo sapiens_hsa051100.50948276
107Small cell lung cancer_Homo sapiens_hsa052220.50667239
108Sphingolipid signaling pathway_Homo sapiens_hsa040710.50128538
109Antigen processing and presentation_Homo sapiens_hsa046120.48087428
110Acute myeloid leukemia_Homo sapiens_hsa052210.47874440
111beta-Alanine metabolism_Homo sapiens_hsa004100.47765260
112Oxidative phosphorylation_Homo sapiens_hsa001900.46728041
113* Melanogenesis_Homo sapiens_hsa049160.46582068
114Tight junction_Homo sapiens_hsa045300.45427564
115Dorso-ventral axis formation_Homo sapiens_hsa043200.45342662
116Insulin resistance_Homo sapiens_hsa049310.44708437
117Neurotrophin signaling pathway_Homo sapiens_hsa047220.44606712
118Pancreatic cancer_Homo sapiens_hsa052120.44220623
119Mineral absorption_Homo sapiens_hsa049780.42656391
120Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42220380
121Fatty acid metabolism_Homo sapiens_hsa012120.41542973
122Phospholipase D signaling pathway_Homo sapiens_hsa040720.39469875
123Bladder cancer_Homo sapiens_hsa052190.39245797
124Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39070600
125N-Glycan biosynthesis_Homo sapiens_hsa005100.38713851
126Arginine and proline metabolism_Homo sapiens_hsa003300.38063611
127Ether lipid metabolism_Homo sapiens_hsa005650.38020530
128Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.37245897
129Endocytosis_Homo sapiens_hsa041440.35975514
130Cysteine and methionine metabolism_Homo sapiens_hsa002700.34685671
131Phosphatidylinositol signaling system_Homo sapiens_hsa040700.34623121
132Type II diabetes mellitus_Homo sapiens_hsa049300.34596397
133FoxO signaling pathway_Homo sapiens_hsa040680.34468874
134Prolactin signaling pathway_Homo sapiens_hsa049170.34227467
135Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.33234109
136Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.32358956
137MicroRNAs in cancer_Homo sapiens_hsa052060.31281399
138AMPK signaling pathway_Homo sapiens_hsa041520.31197242
139Alzheimers disease_Homo sapiens_hsa050100.29840074
140Thyroid cancer_Homo sapiens_hsa052160.29266292
141Pentose and glucuronate interconversions_Homo sapiens_hsa000400.29063888
142Lysine degradation_Homo sapiens_hsa003100.28657133
143Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.28529007
144Oxytocin signaling pathway_Homo sapiens_hsa049210.28516523
145Viral carcinogenesis_Homo sapiens_hsa052030.28016457
146Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.27669844
147Glioma_Homo sapiens_hsa052140.26811922
148Endometrial cancer_Homo sapiens_hsa052130.25551589
149Non-small cell lung cancer_Homo sapiens_hsa052230.23542116

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