MIS12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)5.46581436
2DNA unwinding involved in DNA replication (GO:0006268)5.06482724
3DNA strand elongation involved in DNA replication (GO:0006271)4.76973437
4mitotic chromosome condensation (GO:0007076)4.76183758
5DNA strand elongation (GO:0022616)4.67767696
6protein localization to chromosome, centromeric region (GO:0071459)4.60012897
7DNA replication initiation (GO:0006270)4.51572965
8nuclear pore organization (GO:0006999)4.47749216
9attachment of spindle microtubules to kinetochore (GO:0008608)4.43547771
10mitotic metaphase plate congression (GO:0007080)4.40544224
11nuclear pore complex assembly (GO:0051292)4.39347167
12telomere maintenance via semi-conservative replication (GO:0032201)4.37370436
13DNA replication checkpoint (GO:0000076)4.27971060
14mitotic nuclear envelope disassembly (GO:0007077)4.25889153
15CENP-A containing nucleosome assembly (GO:0034080)4.13729764
16telomere maintenance via recombination (GO:0000722)4.07953711
17mitotic recombination (GO:0006312)4.05208096
18chromatin remodeling at centromere (GO:0031055)4.03994807
19regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.02195007
20proteasome assembly (GO:0043248)3.97163216
21* kinetochore organization (GO:0051383)3.96551972
22nuclear envelope disassembly (GO:0051081)3.95691411
23membrane disassembly (GO:0030397)3.95691411
24sister chromatid segregation (GO:0000819)3.95340952
25regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.93717103
26mitotic sister chromatid segregation (GO:0000070)3.90559731
27DNA double-strand break processing (GO:0000729)3.84014989
28DNA replication-independent nucleosome assembly (GO:0006336)3.83641077
29DNA replication-independent nucleosome organization (GO:0034724)3.83641077
30regulation of spindle organization (GO:0090224)3.82351228
31regulation of chronic inflammatory response (GO:0002676)3.78537962
32folic acid-containing compound biosynthetic process (GO:0009396)3.73046206
33metaphase plate congression (GO:0051310)3.72977791
34DNA ligation (GO:0006266)3.69706543
35mitotic sister chromatid cohesion (GO:0007064)3.67110773
36establishment of integrated proviral latency (GO:0075713)3.65909381
37establishment of chromosome localization (GO:0051303)3.64769195
38nucleotide-excision repair, DNA gap filling (GO:0006297)3.61080656
39telomere maintenance via telomere lengthening (GO:0010833)3.60928072
40somatic hypermutation of immunoglobulin genes (GO:0016446)3.60454467
41somatic diversification of immune receptors via somatic mutation (GO:0002566)3.60454467
42regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.59547518
43negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.55573640
44DNA replication-dependent nucleosome organization (GO:0034723)3.53460163
45DNA replication-dependent nucleosome assembly (GO:0006335)3.53460163
46meiotic chromosome segregation (GO:0045132)3.51790289
47histone exchange (GO:0043486)3.51402665
48regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.48861423
49pore complex assembly (GO:0046931)3.47206010
50non-recombinational repair (GO:0000726)3.45764135
51double-strand break repair via nonhomologous end joining (GO:0006303)3.45764135
52protein localization to chromosome (GO:0034502)3.44882500
53translesion synthesis (GO:0019985)3.42297748
54positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.40214823
55regulation of mitotic spindle checkpoint (GO:1903504)3.38391086
56regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.38391086
57anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.36633607
58positive regulation of chromosome segregation (GO:0051984)3.33309045
59histone mRNA catabolic process (GO:0071044)3.32483916
60nucleobase biosynthetic process (GO:0046112)3.26674422
61somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.26531355
62somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.26531355
63isotype switching (GO:0045190)3.26531355
64IMP biosynthetic process (GO:0006188)3.26476365
65chromatin assembly or disassembly (GO:0006333)3.25051952
66* chromosome segregation (GO:0007059)3.21906165
67heterochromatin organization (GO:0070828)3.20865317
68negative regulation of ligase activity (GO:0051352)3.20054173
69negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.20054173
70postreplication repair (GO:0006301)3.18844579
71monoubiquitinated protein deubiquitination (GO:0035520)3.18113779
72DNA geometric change (GO:0032392)3.17666129
73DNA duplex unwinding (GO:0032508)3.17043364
74positive regulation of granulocyte differentiation (GO:0030854)3.16326806
75mitochondrial RNA metabolic process (GO:0000959)3.15799878
76* kinetochore assembly (GO:0051382)3.14520109
77regulation of immunoglobulin secretion (GO:0051023)3.14278552
78regulation of chromosome segregation (GO:0051983)3.13751021
79cullin deneddylation (GO:0010388)3.11792335
80nuclear envelope organization (GO:0006998)3.11054352
81spindle checkpoint (GO:0031577)3.10937719
82regulation of centrosome cycle (GO:0046605)3.09313557
83ribosome assembly (GO:0042255)3.09125660
84regulation of mitotic spindle organization (GO:0060236)3.06959197
85resolution of meiotic recombination intermediates (GO:0000712)3.05381111
86DNA catabolic process, exonucleolytic (GO:0000738)3.05053148
87IMP metabolic process (GO:0046040)3.04969110
88chromosome condensation (GO:0030261)3.04607004
89formation of translation preinitiation complex (GO:0001731)3.02447495
90synapsis (GO:0007129)2.99211806
91histone-serine phosphorylation (GO:0035404)2.99149468
92positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.98760467
93positive regulation of mitotic sister chromatid separation (GO:1901970)2.98760467
94positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.98760467
95purine nucleobase biosynthetic process (GO:0009113)2.98199242
96protein deneddylation (GO:0000338)2.96318733
97regulation of double-strand break repair via homologous recombination (GO:0010569)2.96176823
98CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.96086992
99ATP-dependent chromatin remodeling (GO:0043044)2.95698126
100regulation of mitotic metaphase/anaphase transition (GO:0030071)2.95335827
101regulation of isotype switching to IgG isotypes (GO:0048302)2.94565033
102regulation of sister chromatid cohesion (GO:0007063)2.90013883
103dosage compensation (GO:0007549)2.89534961
104regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.88961974
105negative regulation of DNA-dependent DNA replication (GO:2000104)2.87558498
106telomere maintenance (GO:0000723)2.87502016
107positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.87161891
108spindle assembly checkpoint (GO:0071173)2.86252741
109DNA conformation change (GO:0071103)2.85108430
110telomere organization (GO:0032200)2.84957457
111somatic cell DNA recombination (GO:0016444)2.84913469
112somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.84913469
113negative regulation of chromosome segregation (GO:0051985)2.83448317
114negative regulation of mitotic sister chromatid separation (GO:2000816)2.83420518
115negative regulation of mitotic sister chromatid segregation (GO:0033048)2.83420518
116negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.83420518
117negative regulation of sister chromatid segregation (GO:0033046)2.83420518
118DNA topological change (GO:0006265)2.83163011
119somatic recombination of immunoglobulin gene segments (GO:0016447)2.81862016
120regulation of podosome assembly (GO:0071801)2.81310270
121protein K11-linked ubiquitination (GO:0070979)2.81063417
122* mitotic cell cycle (GO:0000278)2.80692962
123mismatch repair (GO:0006298)2.80647058
124maturation of 5.8S rRNA (GO:0000460)2.79944102
125mitotic spindle assembly checkpoint (GO:0007094)2.78293011
126negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.75522453
127mitotic DNA integrity checkpoint (GO:0044774)2.74960212
128regulation of double-strand break repair (GO:2000779)2.74906514
129base-excision repair (GO:0006284)2.73358605
130mitotic spindle checkpoint (GO:0071174)2.71314769
131regulation of centriole replication (GO:0046599)2.70260561
132DNA packaging (GO:0006323)2.68489833
133regulation of sister chromatid segregation (GO:0033045)2.67219910
134regulation of mitotic sister chromatid separation (GO:0010965)2.67219910
135regulation of mitotic sister chromatid segregation (GO:0033047)2.67219910
136protein K6-linked ubiquitination (GO:0085020)2.66968556
137histone mRNA metabolic process (GO:0008334)2.65431025

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.33665925
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.15703852
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.47055901
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.41370152
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.15826488
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.09871627
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.81293120
8AR_21909140_ChIP-Seq_LNCAP_Human2.72513194
9CREB1_15753290_ChIP-ChIP_HEK293T_Human2.37136443
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.36943067
11* E2F1_21310950_ChIP-Seq_MCF-7_Human2.36263256
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.29652583
13NELFA_20434984_ChIP-Seq_ESCs_Mouse2.28699038
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.22545205
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.22509604
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.19550313
17* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.11420283
18* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.09694808
19E2F7_22180533_ChIP-Seq_HELA_Human10.3337472
20PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.97282532
21XRN2_22483619_ChIP-Seq_HELA_Human1.93311486
22ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.93225196
23SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.86294457
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.85325897
25MYCN_18555785_ChIP-Seq_MESCs_Mouse1.85225604
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.83952637
27MYC_22102868_ChIP-Seq_BL_Human1.83657779
28ETS1_20019798_ChIP-Seq_JURKAT_Human1.83258454
29VDR_23849224_ChIP-Seq_CD4+_Human1.75406543
30DCP1A_22483619_ChIP-Seq_HELA_Human1.73727198
31* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.73175073
32CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.71245086
33MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.68053356
34MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.67638399
35EWS_26573619_Chip-Seq_HEK293_Human1.66817526
36ELF1_17652178_ChIP-ChIP_JURKAT_Human1.65990081
37* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.65649592
38ELK1_19687146_ChIP-ChIP_HELA_Human1.65245260
39FOXP3_21729870_ChIP-Seq_TREG_Human1.60480030
40* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.59579939
41HOXB4_20404135_ChIP-ChIP_EML_Mouse1.56833923
42GABP_19822575_ChIP-Seq_HepG2_Human1.55478137
43* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.55331219
44NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.54221356
45HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.50223475
46POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.49338546
47KDM5A_27292631_Chip-Seq_BREAST_Human1.43366453
48FUS_26573619_Chip-Seq_HEK293_Human1.41971243
49IRF8_21731497_ChIP-ChIP_J774_Mouse1.41667326
50TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.40216501
51POU3F2_20337985_ChIP-ChIP_501MEL_Human1.37486399
52TFEB_21752829_ChIP-Seq_HELA_Human1.36778385
53PADI4_21655091_ChIP-ChIP_MCF-7_Human1.35592121
54* TTF2_22483619_ChIP-Seq_HELA_Human1.34270771
55ZNF274_21170338_ChIP-Seq_K562_Hela1.33276098
56* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.32868496
57* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.32695705
58NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.30139633
59* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.29983188
60IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.28514710
61YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27695841
62FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.27426550
63ERG_20887958_ChIP-Seq_HPC-7_Mouse1.27347897
64IRF1_19129219_ChIP-ChIP_H3396_Human1.25643506
65FLI1_27457419_Chip-Seq_LIVER_Mouse1.23152647
66CIITA_25753668_ChIP-Seq_RAJI_Human1.23027028
67IGF1R_20145208_ChIP-Seq_DFB_Human1.21163687
68NANOG_18555785_ChIP-Seq_MESCs_Mouse1.20418091
69PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.19509245
70KLF4_18555785_ChIP-Seq_MESCs_Mouse1.18388002
71MYB_21317192_ChIP-Seq_ERMYB_Mouse1.15798923
72SPI1_23547873_ChIP-Seq_NB4_Human1.15681454
73* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.15501348
74* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.15202553
75MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.15092928
76YY1_21170310_ChIP-Seq_MESCs_Mouse1.14062942
77VDR_21846776_ChIP-Seq_THP-1_Human1.13203855
78THAP11_20581084_ChIP-Seq_MESCs_Mouse1.11543851
79ESR1_15608294_ChIP-ChIP_MCF-7_Human1.10918514
80ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.08539115
81CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.07991352
82* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.07612083
83FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.05292500
84GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.04751125
85HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.02783033
86FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.99059788
87SALL1_21062744_ChIP-ChIP_HESCs_Human0.98893632
88CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.96536872
89NANOG_16153702_ChIP-ChIP_HESCs_Human0.95401678
90RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.94974512
91TAF15_26573619_Chip-Seq_HEK293_Human0.94919772
92TP63_19390658_ChIP-ChIP_HaCaT_Human0.94149954
93HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.93020939
94CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.91810642
95MYB_26560356_Chip-Seq_TH2_Human0.91489295
96DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.91102704
97HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.90886435
98SOX17_20123909_ChIP-Seq_XEN_Mouse0.90851825
99IRF8_22096565_ChIP-ChIP_GC-B_Human0.90768009
100STAT3_1855785_ChIP-Seq_MESCs_Mouse0.90411747
101NOTCH1_21737748_ChIP-Seq_TLL_Human0.90406213
102MYC_18940864_ChIP-ChIP_HL60_Human0.90345618
103CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.90244753
104MYB_26560356_Chip-Seq_TH1_Human0.89824062
105* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.88961530
106RBPJ_22232070_ChIP-Seq_NCS_Mouse0.88465255
107CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.88003333
108* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.87429604
109ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.87358490
110NANOG_21062744_ChIP-ChIP_HESCs_Human0.86744005
111PCGF2_27294783_Chip-Seq_ESCs_Mouse0.86679305
112BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.85296585
113* PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.84731759
114SRF_21415370_ChIP-Seq_HL-1_Mouse0.84719233
115GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.84545228
116* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.83561527
117TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81442089
118SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.81103335
119VDR_22108803_ChIP-Seq_LS180_Human0.80636997
120SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.80599191
121POU5F1_16153702_ChIP-ChIP_HESCs_Human0.80597511
122ELK1_22589737_ChIP-Seq_MCF10A_Human0.80413430
123POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.80314718
124SOX2_18555785_ChIP-Seq_MESCs_Mouse0.79867527
125UTX_26944678_Chip-Seq_JUKART_Human0.78134774
126CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.75895288
127SOX2_16153702_ChIP-ChIP_HESCs_Human0.70981779
128TP53_22573176_ChIP-Seq_HFKS_Human0.70383767
129MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.69886168

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.07043680
2MP0010094_abnormal_chromosome_stability4.22432172
3MP0003111_abnormal_nucleus_morphology3.76553777
4MP0003077_abnormal_cell_cycle3.63388109
5MP0004957_abnormal_blastocyst_morpholog3.60214388
6MP0008057_abnormal_DNA_replication3.51927157
7MP0002009_preneoplasia3.30124509
8MP0008007_abnormal_cellular_replicative3.15331851
9MP0010352_gastrointestinal_tract_polyps2.63347005
10MP0008058_abnormal_DNA_repair2.33981388
11MP0010307_abnormal_tumor_latency2.32916140
12MP0000350_abnormal_cell_proliferation2.31499141
13MP0001730_embryonic_growth_arrest2.26037190
14MP0001348_abnormal_lacrimal_gland2.22981326
15MP0003123_paternal_imprinting2.18145886
16MP0003705_abnormal_hypodermis_morpholog2.16504308
17MP0008932_abnormal_embryonic_tissue2.10707012
18MP0002396_abnormal_hematopoietic_system2.06211123
19MP0002102_abnormal_ear_morphology2.05592026
20MP0001873_stomach_inflammation2.05155335
21MP0000372_irregular_coat_pigmentation1.87232916
22MP0006072_abnormal_retinal_apoptosis1.83254394
23MP0006054_spinal_hemorrhage1.83044425
24MP0005076_abnormal_cell_differentiation1.78398409
25MP0000490_abnormal_crypts_of1.75313399
26MP0009333_abnormal_splenocyte_physiolog1.71542776
27MP0004808_abnormal_hematopoietic_stem1.71075932
28MP0001545_abnormal_hematopoietic_system1.61324130
29MP0005397_hematopoietic_system_phenotyp1.61324130
30MP0001697_abnormal_embryo_size1.59540087
31MP0002019_abnormal_tumor_incidence1.55128706
32MP0008877_abnormal_DNA_methylation1.50351247
33MP0001672_abnormal_embryogenesis/_devel1.49732726
34MP0005380_embryogenesis_phenotype1.49732726
35MP0004197_abnormal_fetal_growth/weight/1.45746700
36MP0002163_abnormal_gland_morphology1.44234938
37MP0001835_abnormal_antigen_presentation1.43659899
38MP0010234_abnormal_vibrissa_follicle1.39077935
39MP0003195_calcinosis1.38912587
40MP0003984_embryonic_growth_retardation1.37649803
41MP0002080_prenatal_lethality1.37227474
42MP0001293_anophthalmia1.35943712
43MP0002398_abnormal_bone_marrow1.35816504
44MP0009053_abnormal_anal_canal1.35542531
45MP0008875_abnormal_xenobiotic_pharmacok1.34248376
46MP0002088_abnormal_embryonic_growth/wei1.33359932
47MP0003937_abnormal_limbs/digits/tail_de1.32888797
48MP0003656_abnormal_erythrocyte_physiolo1.32754289
49MP0002086_abnormal_extraembryonic_tissu1.30996695
50MP0000313_abnormal_cell_death1.28551237
51MP0002085_abnormal_embryonic_tissue1.25228030
52MP0001529_abnormal_vocalization1.24623744
53MP0002160_abnormal_reproductive_system1.22342746
54MP0003763_abnormal_thymus_physiology1.20460920
55MP0002084_abnormal_developmental_patter1.20295690
56MP0003436_decreased_susceptibility_to1.19352270
57MP0010030_abnormal_orbit_morphology1.18644118
58MP0000703_abnormal_thymus_morphology1.17145812
59MP0000689_abnormal_spleen_morphology1.15541011
60MP0003890_abnormal_embryonic-extraembry1.14434401
61MP0002722_abnormal_immune_system1.14168745
62MP0005253_abnormal_eye_physiology1.13751610
63MP0001919_abnormal_reproductive_system1.10349237
64MP0003786_premature_aging1.09216448
65MP0002429_abnormal_blood_cell1.04546328
66MP0000427_abnormal_hair_cycle1.04144526
67MP0003121_genomic_imprinting1.03824535
68MP0001800_abnormal_humoral_immune1.02929500
69MP0002452_abnormal_antigen_presenting1.00404257
70MP0005389_reproductive_system_phenotype1.00139443
71MP0003303_peritoneal_inflammation1.00077751
72MP0000716_abnormal_immune_system0.99709915
73MP0000858_altered_metastatic_potential0.99500144
74MP0005379_endocrine/exocrine_gland_phen0.97396451
75MP0006292_abnormal_olfactory_placode0.96641097
76MP0003787_abnormal_imprinting0.96060664
77MP0005075_abnormal_melanosome_morpholog0.95433275
78MP0001984_abnormal_olfaction0.95254161
79MP0009785_altered_susceptibility_to0.95183605
80MP0005023_abnormal_wound_healing0.94917427
81MP0006035_abnormal_mitochondrial_morpho0.93606910
82MP0006036_abnormal_mitochondrial_physio0.93502987
83MP0005408_hypopigmentation0.92591930
84MP0002006_tumorigenesis0.92501927
85MP0001119_abnormal_female_reproductive0.92285067
86MP0010678_abnormal_skin_adnexa0.92156872
87MP0001819_abnormal_immune_cell0.90384714
88MP0003567_abnormal_fetal_cardiomyocyte0.90268924
89MP0002420_abnormal_adaptive_immunity0.90249736
90MP0001915_intracranial_hemorrhage0.90209185
91MP0003806_abnormal_nucleotide_metabolis0.89153998
92MP0008872_abnormal_physiological_respon0.89082470
93MP0005000_abnormal_immune_tolerance0.88884891
94MP0003186_abnormal_redox_activity0.88283573
95MP0009697_abnormal_copulation0.87421427
96MP0005025_abnormal_response_to0.87170516
97MP0005621_abnormal_cell_physiology0.86808692
98MP0005084_abnormal_gallbladder_morpholo0.86559173
99MP0005671_abnormal_response_to0.85298193
100MP0002419_abnormal_innate_immunity0.83277254
101MP0001764_abnormal_homeostasis0.83042951
102MP0002723_abnormal_immune_serum0.82401790
103MP0002210_abnormal_sex_determination0.81822575
104MP0000465_gastrointestinal_hemorrhage0.80296600
105MP0002405_respiratory_system_inflammati0.80269296
106MP0000516_abnormal_urinary_system0.80226440
107MP0005367_renal/urinary_system_phenotyp0.80226440
108MP0003718_maternal_effect0.80201652
109MP0005464_abnormal_platelet_physiology0.80099825
110MP0000685_abnormal_immune_system0.80046822
111MP0003941_abnormal_skin_development0.79417064
112MP0005310_abnormal_salivary_gland0.78242694
113MP0005395_other_phenotype0.77960261
114MP0003698_abnormal_male_reproductive0.77069768
115MP0009278_abnormal_bone_marrow0.76353732
116MP0003448_altered_tumor_morphology0.76277703
117MP0005384_cellular_phenotype0.75930108
118MP0002166_altered_tumor_susceptibility0.75873999
119MP0000477_abnormal_intestine_morphology0.75670077
120MP0001286_abnormal_eye_development0.75554294
121MP0005387_immune_system_phenotype0.75402028
122MP0001790_abnormal_immune_system0.75402028
123MP0002277_abnormal_respiratory_mucosa0.75238791
124MP0004947_skin_inflammation0.74932767
125MP0003566_abnormal_cell_adhesion0.73776513
126MP0008438_abnormal_cutaneous_collagen0.73682799
127MP0000733_abnormal_muscle_development0.73299548
128MP0002877_abnormal_melanocyte_morpholog0.72952001
129MP0000598_abnormal_liver_morphology0.72455514
130MP0005391_vision/eye_phenotype0.72038972
131MP0001145_abnormal_male_reproductive0.71168879
132MP0001849_ear_inflammation0.71139362
133MP0001188_hyperpigmentation0.70945777
134MP0003115_abnormal_respiratory_system0.70573087
135MP0003300_gastrointestinal_ulcer0.70131805
136MP0009672_abnormal_birth_weight0.70128840
137MP0002938_white_spotting0.70087733
138MP0001727_abnormal_embryo_implantation0.68743648
139MP0000653_abnormal_sex_gland0.68101965
140MP0000358_abnormal_cell_content/0.67945196
141MP0003221_abnormal_cardiomyocyte_apopto0.67218235
142MP0005645_abnormal_hypothalamus_physiol0.66258671
143MP0000383_abnormal_hair_follicle0.65500126
144MP0010155_abnormal_intestine_physiology0.65040847
145MP0001929_abnormal_gametogenesis0.64914124
146MP0005257_abnormal_intraocular_pressure0.64814939
147MP0005220_abnormal_exocrine_pancreas0.61787830

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)6.22109370
2Breast hypoplasia (HP:0003187)3.55024749
3Chromsome breakage (HP:0040012)3.09511918
4Facial hemangioma (HP:0000329)3.08377147
5Patellar aplasia (HP:0006443)2.94423846
6Acute myeloid leukemia (HP:0004808)2.91151058
7Abnormality of chromosome stability (HP:0003220)2.89522026
8Combined immunodeficiency (HP:0005387)2.85361491
9Agnosia (HP:0010524)2.85078132
10Cortical dysplasia (HP:0002539)2.79344523
11Thrombocytosis (HP:0001894)2.78070429
12Severe combined immunodeficiency (HP:0004430)2.77129226
13Increased hepatocellular lipid droplets (HP:0006565)2.76493115
14Oral leukoplakia (HP:0002745)2.75130632
15Chromosomal breakage induced by crosslinking agents (HP:0003221)2.74315210
16Cutaneous melanoma (HP:0012056)2.73112391
17Pancreatic cysts (HP:0001737)2.71334831
18Abnormality of the labia minora (HP:0012880)2.70815784
19Entropion (HP:0000621)2.68232592
20Aplasia/Hypoplasia of the patella (HP:0006498)2.67379664
21Slender long bone (HP:0003100)2.63550621
22Lipid accumulation in hepatocytes (HP:0006561)2.62230142
23Nephroblastoma (Wilms tumor) (HP:0002667)2.61636654
24Thyroiditis (HP:0100646)2.56054777
25Deviation of the thumb (HP:0009603)2.54571504
26Embryonal renal neoplasm (HP:0011794)2.54567916
27Neoplasm of the adrenal cortex (HP:0100641)2.50681276
28High pitched voice (HP:0001620)2.47175949
29Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.47023903
30Short 4th metacarpal (HP:0010044)2.47023903
31Degeneration of anterior horn cells (HP:0002398)2.46965630
32Abnormality of the anterior horn cell (HP:0006802)2.46965630
33Selective tooth agenesis (HP:0001592)2.46285366
34True hermaphroditism (HP:0010459)2.46190060
35Proximal placement of thumb (HP:0009623)2.45676260
36IgG deficiency (HP:0004315)2.40101929
37Microvesicular hepatic steatosis (HP:0001414)2.37833137
38Impulsivity (HP:0100710)2.37404299
39Aplastic anemia (HP:0001915)2.37164077
40Abnormality of methionine metabolism (HP:0010901)2.36985512
41Pancreatic fibrosis (HP:0100732)2.34168740
42B lymphocytopenia (HP:0010976)2.33386609
43Volvulus (HP:0002580)2.32739002
44Conjunctival telangiectasia (HP:0000524)2.32460946
45Squamous cell carcinoma (HP:0002860)2.31876181
46Abnormal lung lobation (HP:0002101)2.31801417
47Poikiloderma (HP:0001029)2.29508168
48Medulloblastoma (HP:0002885)2.28559609
49Ependymoma (HP:0002888)2.28550036
50Premature graying of hair (HP:0002216)2.27880318
51Myelodysplasia (HP:0002863)2.26010340
52Neoplasm of the adrenal gland (HP:0100631)2.21335920
53Hypoplasia of the pons (HP:0012110)2.18648296
54Abnormality of the pons (HP:0007361)2.18446139
55Cellular immunodeficiency (HP:0005374)2.17309560
56Increased CSF lactate (HP:0002490)2.15354213
57Poor head control (HP:0002421)2.14171011
58Recurrent viral infections (HP:0004429)2.14132640
59Pancytopenia (HP:0001876)2.13949557
60Ankle contracture (HP:0006466)2.13390677
61Disinhibition (HP:0000734)2.12291366
62Ectopic kidney (HP:0000086)2.11980459
63Rough bone trabeculation (HP:0100670)2.09622165
64Carpal bone hypoplasia (HP:0001498)2.07406585
65Meckel diverticulum (HP:0002245)2.06938359
66Abnormality of the duodenum (HP:0002246)2.06901987
67Deep philtrum (HP:0002002)2.06026313
68Atresia of the external auditory canal (HP:0000413)2.05597811
69Increased nuchal translucency (HP:0010880)2.05561773
70Abnormality of the metopic suture (HP:0005556)2.03558987
71Neoplasm of the pancreas (HP:0002894)2.01460086
72Abnormality of B cell number (HP:0010975)2.00445921
73Wrist flexion contracture (HP:0001239)1.99890935
74Microtia (HP:0008551)1.99843312
75Increased serum lactate (HP:0002151)1.99170088
76Colon cancer (HP:0003003)1.98416616
77Prominent metopic ridge (HP:0005487)1.98102131
78Large for gestational age (HP:0001520)1.97566842
79Acute encephalopathy (HP:0006846)1.96775706
80Supernumerary spleens (HP:0009799)1.96768216
81Acute necrotizing encephalopathy (HP:0006965)1.96567663
82Aplasia/Hypoplasia of the uvula (HP:0010293)1.96555644
83Cafe-au-lait spot (HP:0000957)1.95034283
84Abnormality of the vasculature of the conjunctiva (HP:0008054)1.94809056
85Abnormality of the ileum (HP:0001549)1.93762022
86Methylmalonic acidemia (HP:0002912)1.93555136
87Abnormality of the 4th metacarpal (HP:0010012)1.93192697
88Sloping forehead (HP:0000340)1.92494838
89Intestinal atresia (HP:0011100)1.92457127
90Cerebral edema (HP:0002181)1.92165061
91Cellulitis (HP:0100658)1.91497056
92Bone marrow hypocellularity (HP:0005528)1.91219741
93Protrusio acetabuli (HP:0003179)1.90458780
94Lymphoma (HP:0002665)1.90004353
95Ovarian neoplasm (HP:0100615)1.89938885
96Abnormality of pyrimidine metabolism (HP:0004353)1.89896176
97Abnormality of the preputium (HP:0100587)1.89176862
98Abnormality of aspartate family amino acid metabolism (HP:0010899)1.89152785
99Freckling (HP:0001480)1.88937367
100Thoracolumbar scoliosis (HP:0002944)1.88911183
101Hyperinsulinemic hypoglycemia (HP:0000825)1.88804761
102Progressive macrocephaly (HP:0004481)1.88799724
103Increased density of long bones (HP:0006392)1.86662925
104Aseptic necrosis (HP:0010885)1.86389683
105Absent radius (HP:0003974)1.86382499
106Hypoproteinemia (HP:0003075)1.86080943
107Horseshoe kidney (HP:0000085)1.83778627
108Mitochondrial inheritance (HP:0001427)1.83634697
109Biconcave vertebral bodies (HP:0004586)1.83368167
110Molar tooth sign on MRI (HP:0002419)1.82882234
111Abnormality of midbrain morphology (HP:0002418)1.82882234
112Pancreatic islet-cell hyperplasia (HP:0004510)1.80746509
113Long clavicles (HP:0000890)1.80700849
114Reticulocytopenia (HP:0001896)1.79630374
115Hypoplasia of the capital femoral epiphysis (HP:0003090)1.79096188
116Optic nerve coloboma (HP:0000588)1.78498152
117Megaloblastic anemia (HP:0001889)1.77588909
118Rhabdomyosarcoma (HP:0002859)1.76964028
119Clubbing of toes (HP:0100760)1.75830125
120Overlapping toe (HP:0001845)1.75287540
121Anencephaly (HP:0002323)1.74206897
122Eosinophilia (HP:0001880)1.73826790
123Basal cell carcinoma (HP:0002671)1.73826227
124Abnormality of DNA repair (HP:0003254)1.73625456
125IgM deficiency (HP:0002850)1.73232923
126Hypoplasia of the thymus (HP:0000778)1.72872311
127Oligodactyly (hands) (HP:0001180)1.72856372
128Hypothermia (HP:0002045)1.72467515
129Aplasia/Hypoplasia of the sternum (HP:0006714)1.71361036
130Capillary hemangiomas (HP:0005306)1.71109584
131Small intestinal stenosis (HP:0012848)1.70972488
132Duodenal stenosis (HP:0100867)1.70972488
133Biliary tract neoplasm (HP:0100574)1.70953192
134Teleangiectasia of the skin (HP:0100585)1.70472083
135Type I transferrin isoform profile (HP:0003642)1.69376092
136Pendular nystagmus (HP:0012043)1.69158771
137Dandy-Walker malformation (HP:0001305)1.68860092
138Osteolytic defects of the hand bones (HP:0009699)1.68296136
139Osteolytic defects of the phalanges of the hand (HP:0009771)1.68296136
140Thyroid carcinoma (HP:0002890)1.67408126
141Pelvic girdle muscle weakness (HP:0003749)1.66939319
142Absent forearm bone (HP:0003953)1.66562550
143Aplasia involving forearm bones (HP:0009822)1.66562550
144Abnormal spermatogenesis (HP:0008669)1.66495586
145Lactic acidosis (HP:0003128)1.66388079
146Breast carcinoma (HP:0003002)1.66304518
147Tracheoesophageal fistula (HP:0002575)1.66242898
148Glioma (HP:0009733)1.66229776
149Increased serum pyruvate (HP:0003542)1.66151794
150Long eyelashes (HP:0000527)1.65387095
151Methylmalonic aciduria (HP:0012120)1.65205351
152Cutis marmorata (HP:0000965)1.65054621
153Hypoglycemic seizures (HP:0002173)1.64938216
154Preaxial hand polydactyly (HP:0001177)1.64822864
155Prominent nose (HP:0000448)1.64614077
156Hematochezia (HP:0002573)1.63759953
157Progressive inability to walk (HP:0002505)1.63308007
158Neoplasm of the small intestine (HP:0100833)1.62811575
159Renal Fanconi syndrome (HP:0001994)1.62700770
160Abnormal mitochondria in muscle tissue (HP:0008316)1.62693917
161Recurrent abscess formation (HP:0002722)1.62626444
162Chronic otitis media (HP:0000389)1.62614053
163Glossoptosis (HP:0000162)1.62486364
164Neoplasm of the colon (HP:0100273)1.62145622
165Spastic diplegia (HP:0001264)1.61585088
166Atrophy/Degeneration involving motor neurons (HP:0007373)1.61226058
167Recurrent gram-negative bacterial infections (HP:0005420)1.60445932

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.98286167
2WEE13.44805418
3BUB13.44577616
4EIF2AK13.41400614
5NEK23.05264488
6TRIM282.87934430
7PLK42.26760603
8BRSK22.23226600
9CDK122.20158925
10TTK2.07710267
11ZAK2.04420523
12SRPK12.02556038
13ACVR1B1.97845045
14NEK11.92515081
15MST41.87646826
16STK101.79020454
17SCYL21.77520291
18NME21.75812346
19RPS6KA41.74823116
20VRK21.72244423
21PLK11.71828671
22NUAK11.69359701
23ATR1.65481151
24EIF2AK31.65474266
25PLK31.65093878
26LATS11.63023827
27TESK21.62725487
28STK31.56880607
29CDK71.56654995
30CDK41.56001888
31CHEK21.52032764
32AURKB1.50638293
33BCR1.49117424
34TNIK1.48158783
35MAP3K81.44805637
36TSSK61.42452160
37ERBB31.41134764
38BRSK11.39583315
39WNK31.39020167
40NEK91.30038035
41BMPR1B1.29941439
42EEF2K1.28887934
43PBK1.27434779
44CHEK11.25928926
45MKNK11.23888880
46JAK31.23886923
47MAP2K71.23454274
48PASK1.21046601
49DYRK31.20612197
50NME11.20041417
51STK41.17672338
52MELK1.15642872
53FLT31.12764733
54TAF11.11207473
55PDK21.07373621
56PKN21.02613412
57MAP3K41.00783067
58BCKDK1.00057735
59NLK0.99525441
60RPS6KB20.98089143
61TGFBR10.97305114
62CSNK1G30.96231630
63PIM10.95329609
64LRRK20.94619516
65CDK80.94506671
66CDK60.94002386
67TYK20.92364630
68MAP4K20.92347974
69BRD40.91222249
70ATM0.90641830
71CSNK1G10.89442188
72PDGFRA0.84389997
73MAP3K120.82699759
74AURKA0.82425188
75MAP3K100.80840541
76VRK10.79125946
77MAP4K10.78714596
78PAK40.73797423
79CDK20.73227094
80MAP3K110.72660997
81ERN10.72248996
82KIT0.70373018
83STK38L0.69143875
84CSNK1G20.68016169
85TESK10.67800939
86PIM20.65115730
87ERBB40.63839115
88MAP3K50.61285610
89CDK10.60794868
90RAF10.59298677
91CCNB10.58196851
92MARK30.56081040
93CSF1R0.55392944
94PNCK0.55383388
95BRAF0.54250023
96DYRK20.52120880
97MKNK20.51299163
98STK160.50432081
99ZAP700.50155803
100LATS20.49552381
101GRK10.48851777
102CSNK1A1L0.47511345
103CHUK0.46691838
104ABL20.44879885
105TLK10.44023396
106KSR20.42817668
107KSR10.42726314
108BTK0.41035420
109TEC0.40946631
110FGFR20.39905157
111RPS6KA50.39621651
112TRPM70.39564128
113YES10.39300271
114MTOR0.39216696
115MAP3K140.38225840
116CSNK2A20.37880806
117MAP3K130.37652675
118PDGFRB0.37473346
119TRIB30.36872538
120FRK0.35638527
121JAK10.35620324
122MAPK110.35342287
123CSNK2A10.33487427
124LYN0.33313002
125ALK0.33225150
126SIK30.31806044
127PLK20.30830053
128JAK20.30624144
129PAK10.30468096
130EIF2AK20.29461658
131ADRBK20.29294989
132CLK10.27839595
133CDK30.27176117
134CAMKK20.24310261
135PRKDC0.22971076
136EPHA30.22217139
137IKBKB0.22144269
138RPS6KB10.21081010
139STK390.19428311
140STK240.19414282
141PRKCQ0.18481369

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.99762052
2Mismatch repair_Homo sapiens_hsa034304.08090776
3Cell cycle_Homo sapiens_hsa041103.24887794
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.83134159
5Homologous recombination_Homo sapiens_hsa034402.82318535
6Nucleotide excision repair_Homo sapiens_hsa034202.70089517
7RNA transport_Homo sapiens_hsa030132.66598370
8Base excision repair_Homo sapiens_hsa034102.65064444
9Spliceosome_Homo sapiens_hsa030402.61619669
10One carbon pool by folate_Homo sapiens_hsa006702.54826301
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.22655777
12p53 signaling pathway_Homo sapiens_hsa041152.05944056
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.93440244
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.90982005
15Proteasome_Homo sapiens_hsa030501.89988204
16Non-homologous end-joining_Homo sapiens_hsa034501.87745833
17Fanconi anemia pathway_Homo sapiens_hsa034601.83582060
18RNA degradation_Homo sapiens_hsa030181.78151273
19Pyrimidine metabolism_Homo sapiens_hsa002401.77443109
20RNA polymerase_Homo sapiens_hsa030201.71183290
21Basal transcription factors_Homo sapiens_hsa030221.57476985
22Sulfur relay system_Homo sapiens_hsa041221.46459334
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.46093828
24Folate biosynthesis_Homo sapiens_hsa007901.43444101
25Propanoate metabolism_Homo sapiens_hsa006401.41276803
26Autoimmune thyroid disease_Homo sapiens_hsa053201.40700497
27Herpes simplex infection_Homo sapiens_hsa051681.35612003
28Systemic lupus erythematosus_Homo sapiens_hsa053221.35387743
29Steroid biosynthesis_Homo sapiens_hsa001001.27930502
30mRNA surveillance pathway_Homo sapiens_hsa030151.27343706
31Viral carcinogenesis_Homo sapiens_hsa052031.26349444
32Antigen processing and presentation_Homo sapiens_hsa046121.23417073
33Pentose phosphate pathway_Homo sapiens_hsa000301.21434097
34Epstein-Barr virus infection_Homo sapiens_hsa051691.21042962
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.20985388
36Selenocompound metabolism_Homo sapiens_hsa004501.18521825
37Legionellosis_Homo sapiens_hsa051341.13295241
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.13152365
39MicroRNAs in cancer_Homo sapiens_hsa052061.08352219
40Oxidative phosphorylation_Homo sapiens_hsa001901.04080186
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.02808686
42Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.99529909
43Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.98048918
44Parkinsons disease_Homo sapiens_hsa050120.97922819
45Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.97540457
46Cysteine and methionine metabolism_Homo sapiens_hsa002700.95198160
47Ribosome_Homo sapiens_hsa030100.94814942
48Fatty acid elongation_Homo sapiens_hsa000620.94063204
49Hepatitis B_Homo sapiens_hsa051610.94041860
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.92778215
51Small cell lung cancer_Homo sapiens_hsa052220.90954348
52Leishmaniasis_Homo sapiens_hsa051400.90932953
53Phototransduction_Homo sapiens_hsa047440.89601005
54Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.89175930
55Biosynthesis of amino acids_Homo sapiens_hsa012300.88804439
56HTLV-I infection_Homo sapiens_hsa051660.87910256
57Measles_Homo sapiens_hsa051620.87476600
58NF-kappa B signaling pathway_Homo sapiens_hsa040640.86171996
59Chronic myeloid leukemia_Homo sapiens_hsa052200.82762416
60Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.81795154
61Oocyte meiosis_Homo sapiens_hsa041140.80268335
62Thyroid cancer_Homo sapiens_hsa052160.79338029
63Vitamin B6 metabolism_Homo sapiens_hsa007500.78339069
64Huntingtons disease_Homo sapiens_hsa050160.75883742
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.75681261
66Shigellosis_Homo sapiens_hsa051310.75527101
67Influenza A_Homo sapiens_hsa051640.74832658
68Butanoate metabolism_Homo sapiens_hsa006500.73932745
69Drug metabolism - other enzymes_Homo sapiens_hsa009830.73200864
70Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.72285317
71Pyruvate metabolism_Homo sapiens_hsa006200.71961273
72Pancreatic cancer_Homo sapiens_hsa052120.71861788
73Apoptosis_Homo sapiens_hsa042100.68338216
74Lysine degradation_Homo sapiens_hsa003100.65417913
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.65034245
76Purine metabolism_Homo sapiens_hsa002300.64265407
77RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.58357572
78NOD-like receptor signaling pathway_Homo sapiens_hsa046210.56608036
79Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55038991
80TGF-beta signaling pathway_Homo sapiens_hsa043500.54804439
81Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54760494
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.52916951
83Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.52525035
84Pertussis_Homo sapiens_hsa051330.51376353
85Primary immunodeficiency_Homo sapiens_hsa053400.51368856
86Fatty acid metabolism_Homo sapiens_hsa012120.50895324
87Toll-like receptor signaling pathway_Homo sapiens_hsa046200.50135770
88Protein export_Homo sapiens_hsa030600.49148994
89Prostate cancer_Homo sapiens_hsa052150.49024934
90Bladder cancer_Homo sapiens_hsa052190.47242854
91Maturity onset diabetes of the young_Homo sapiens_hsa049500.47121903
92Colorectal cancer_Homo sapiens_hsa052100.47037445
93Intestinal immune network for IgA production_Homo sapiens_hsa046720.46461327
94N-Glycan biosynthesis_Homo sapiens_hsa005100.46358628
95Peroxisome_Homo sapiens_hsa041460.45851295
96Viral myocarditis_Homo sapiens_hsa054160.45631289
97Toxoplasmosis_Homo sapiens_hsa051450.44528391
98T cell receptor signaling pathway_Homo sapiens_hsa046600.43739463
99Circadian rhythm_Homo sapiens_hsa047100.43218672
100Glutathione metabolism_Homo sapiens_hsa004800.42785914
101Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.40590343
102Non-small cell lung cancer_Homo sapiens_hsa052230.40573392
103Caffeine metabolism_Homo sapiens_hsa002320.40021856
104Metabolic pathways_Homo sapiens_hsa011000.39707399
105Carbon metabolism_Homo sapiens_hsa012000.38952465
106B cell receptor signaling pathway_Homo sapiens_hsa046620.38913722
107Tuberculosis_Homo sapiens_hsa051520.38267143
108Type I diabetes mellitus_Homo sapiens_hsa049400.38118681
109Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.37937210
110Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.36676795
111Jak-STAT signaling pathway_Homo sapiens_hsa046300.35582924
112Osteoclast differentiation_Homo sapiens_hsa043800.33756678
113Hematopoietic cell lineage_Homo sapiens_hsa046400.33119708
114Sulfur metabolism_Homo sapiens_hsa009200.32987248
115Adherens junction_Homo sapiens_hsa045200.32836812
116Allograft rejection_Homo sapiens_hsa053300.32578224
1172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.31756773
118Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.31284979
119Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.30498763
120Alcoholism_Homo sapiens_hsa050340.29516144
121Fatty acid degradation_Homo sapiens_hsa000710.29214261
122Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.28238478
123Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.28152233
124Central carbon metabolism in cancer_Homo sapiens_hsa052300.28135037
125Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.27925806
126Phagosome_Homo sapiens_hsa041450.26890405
127Asthma_Homo sapiens_hsa053100.26842094
128TNF signaling pathway_Homo sapiens_hsa046680.26586065
129Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.26312465
130Staphylococcus aureus infection_Homo sapiens_hsa051500.25887682
131Malaria_Homo sapiens_hsa051440.25684322
132Regulation of autophagy_Homo sapiens_hsa041400.25608271
133Leukocyte transendothelial migration_Homo sapiens_hsa046700.25582784
134Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.25529417
135mTOR signaling pathway_Homo sapiens_hsa041500.25075591
136Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.25061582
137Alzheimers disease_Homo sapiens_hsa050100.24200894
138Nitrogen metabolism_Homo sapiens_hsa009100.22438746
139beta-Alanine metabolism_Homo sapiens_hsa004100.18529765

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