MIR1199

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1thrombin receptor signaling pathway (GO:0070493)5.00162529
2neutrophil activation involved in immune response (GO:0002283)4.96818553
3protein neddylation (GO:0045116)4.60039199
4adenosine receptor signaling pathway (GO:0001973)4.59243124
5triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.23769338
6blood coagulation, intrinsic pathway (GO:0007597)4.00959289
7regulation of integrin-mediated signaling pathway (GO:2001044)3.97701509
8negative regulation of norepinephrine secretion (GO:0010700)3.96131239
9regulation of platelet aggregation (GO:0090330)3.93346075
10negative regulation of homotypic cell-cell adhesion (GO:0034111)3.74904368
11low-density lipoprotein particle remodeling (GO:0034374)3.73854072
12platelet aggregation (GO:0070527)3.59908963
13regulation of platelet activation (GO:0010543)3.50564480
14lipoxygenase pathway (GO:0019372)3.47845625
15vesicle targeting (GO:0006903)3.45968356
16negative regulation of focal adhesion assembly (GO:0051895)3.38839749
17negative regulation of cell junction assembly (GO:1901889)3.38839749
18negative regulation of adherens junction organization (GO:1903392)3.38839749
19regulation of interleukin-13 production (GO:0032656)3.27843416
20negative regulation of platelet activation (GO:0010544)3.18674740
21positive regulation of receptor recycling (GO:0001921)3.14301760
22negative regulation of protein localization to cell surface (GO:2000009)3.14204229
23leukocyte migration involved in inflammatory response (GO:0002523)3.11427109
24positive regulation of Cdc42 GTPase activity (GO:0043089)3.09566166
25positive regulation of systemic arterial blood pressure (GO:0003084)3.07973842
26platelet degranulation (GO:0002576)3.05998855
27regulation of lipoprotein metabolic process (GO:0050746)3.03990160
28negative regulation of heart rate (GO:0010459)2.99951463
29regulation of T-helper 2 cell differentiation (GO:0045628)2.99655943
30axonemal dynein complex assembly (GO:0070286)2.96175519
31negative regulation of thymocyte apoptotic process (GO:0070244)2.92430421
32calcium-mediated signaling using intracellular calcium source (GO:0035584)2.91110759
33activation of protein kinase A activity (GO:0034199)2.90959058
34G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.88461946
35neutrophil activation (GO:0042119)2.88287030
36platelet activation (GO:0030168)2.87062950
37negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.85619849
38regulation of early endosome to late endosome transport (GO:2000641)2.83396475
39regulation of integrin activation (GO:0033623)2.81849746
40G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.77428848
41positive regulation of mast cell activation (GO:0033005)2.76605248
42positive regulation of endothelial cell differentiation (GO:0045603)2.75055448
43regulation of female receptivity (GO:0045924)2.72850551
44positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.72353144
45actin filament polymerization (GO:0030041)2.69975345
46erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.69199592
47L-phenylalanine metabolic process (GO:0006558)2.69199592
48phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.68665377
49negative regulation of catecholamine secretion (GO:0033604)2.67143940
50myelin maintenance (GO:0043217)2.65883794
51high-density lipoprotein particle remodeling (GO:0034375)2.65594923
52beta-amyloid metabolic process (GO:0050435)2.63779860
53homotypic cell-cell adhesion (GO:0034109)2.63227359
54negative regulation of heart contraction (GO:0045822)2.61506569
55autophagic vacuole fusion (GO:0000046)2.61198726
56regulation of receptor recycling (GO:0001919)2.60392260
57reverse cholesterol transport (GO:0043691)2.54656885
58water transport (GO:0006833)2.54049552
59regulation of norepinephrine secretion (GO:0014061)2.53716974
60positive regulation of cellular amine metabolic process (GO:0033240)2.53134822
61granulocyte activation (GO:0036230)2.52939791
62cyclooxygenase pathway (GO:0019371)2.50945572
63signal complex assembly (GO:0007172)2.50885568
64negative regulation of neural precursor cell proliferation (GO:2000178)2.48989315
65cellular response to prostaglandin stimulus (GO:0071379)2.47619747
66protein insertion into membrane (GO:0051205)2.46581286
67negative regulation of protein localization to plasma membrane (GO:1903077)2.45670687
68purinergic receptor signaling pathway (GO:0035587)2.44442239
69positive regulation of Rho protein signal transduction (GO:0035025)2.44348873
70cerebellar granule cell differentiation (GO:0021707)2.43580052
71platelet formation (GO:0030220)2.43336248
72erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.40182253
73L-phenylalanine catabolic process (GO:0006559)2.40182253
74purinergic nucleotide receptor signaling pathway (GO:0035590)2.39576201
75megakaryocyte development (GO:0035855)2.39549599
76peptide catabolic process (GO:0043171)2.39528896
77regulation of sensory perception of pain (GO:0051930)2.39138991
78regulation of sensory perception (GO:0051931)2.39138991
79motile cilium assembly (GO:0044458)2.38459010
80angiogenesis involved in wound healing (GO:0060055)2.37304804
81positive regulation of hemostasis (GO:1900048)2.36145351
82positive regulation of blood coagulation (GO:0030194)2.36145351
83long-chain fatty acid biosynthetic process (GO:0042759)2.35680187
84regulation of clathrin-mediated endocytosis (GO:2000369)2.35588561
85response to magnesium ion (GO:0032026)2.34117669
86regulation of macrophage derived foam cell differentiation (GO:0010743)2.33873677
87fusion of sperm to egg plasma membrane (GO:0007342)2.33783200
88negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.32940222
89nucleoside diphosphate biosynthetic process (GO:0009133)2.32845794
90regulation of cholesterol efflux (GO:0010874)2.32292515
91female mating behavior (GO:0060180)2.30240377
92negative regulation of response to food (GO:0032096)2.26436429
93negative regulation of appetite (GO:0032099)2.26436429
94fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.24857504
95epithelial cell-cell adhesion (GO:0090136)2.24849296
96regulation of cholesterol metabolic process (GO:0090181)2.23522432
97regulation of protein localization to cell surface (GO:2000008)2.22861137
98regulation of homotypic cell-cell adhesion (GO:0034110)2.22566315
99fluid transport (GO:0042044)2.22215170
100negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.21110626

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR2_21235772_ChIP-Seq_MCF-7_Human3.16740904
2ESR1_21235772_ChIP-Seq_MCF-7_Human2.94093186
3SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.90575368
4THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.89527963
5ESR1_20079471_ChIP-ChIP_T-47D_Human2.38310898
6SRY_22984422_ChIP-ChIP_TESTIS_Rat2.38259584
7SCL_19346495_ChIP-Seq_HPC-7_Human2.31377064
8LXR_22292898_ChIP-Seq_THP-1_Human2.28303019
9TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.26527815
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.23947149
11GATA1_19941827_ChIP-Seq_MEL_Mouse2.22240825
12GATA1_19941826_ChIP-Seq_K562_Human2.21556454
13LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.19647611
14RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.00947712
15RARG_19884340_ChIP-ChIP_MEFs_Mouse1.97556211
16RACK7_27058665_Chip-Seq_MCF-7_Human1.93858394
17IKZF1_21737484_ChIP-ChIP_HCT116_Human1.76528751
18DROSHA_22980978_ChIP-Seq_HELA_Human1.73510004
19GATA1_22383799_ChIP-Seq_G1ME_Mouse1.73459209
20GATA2_19941826_ChIP-Seq_K562_Human1.72857423
21TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.70694665
22GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.70457249
23KDM2B_26808549_Chip-Seq_SUP-B15_Human1.70196842
24LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.66731268
25SPI1_23127762_ChIP-Seq_K562_Human1.58162680
26P68_20966046_ChIP-Seq_HELA_Human1.57479032
27RUNX1_27514584_Chip-Seq_MCF-7_Human1.56387279
28TP63_17297297_ChIP-ChIP_HaCaT_Human1.54391248
29EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.53100964
30RXR_22158963_ChIP-Seq_LIVER_Mouse1.52750368
31GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.52494544
32MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.44624288
33SOX2_27498859_Chip-Seq_STOMACH_Mouse1.44181394
34ERG_21242973_ChIP-ChIP_JURKAT_Human1.43661841
35TCF7_22412390_ChIP-Seq_EML_Mouse1.43177913
36PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.42813995
37CDX2_20551321_ChIP-Seq_CACO-2_Human1.42462488
38RUNX1_22412390_ChIP-Seq_EML_Mouse1.42144351
39ELK3_25401928_ChIP-Seq_HUVEC_Human1.41556754
40PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.39771978
41EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.37741142
42CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.37136455
43ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.36048117
44SMC4_20622854_ChIP-Seq_HELA_Human1.34586390
45CTCF_27219007_Chip-Seq_ERYTHROID_Human1.33392462
46SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.32963624
47E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.32276303
48BCOR_27268052_Chip-Seq_Bcells_Human1.31185712
49PPARA_22158963_ChIP-Seq_LIVER_Mouse1.29785917
50STAT6_21828071_ChIP-Seq_BEAS2B_Human1.29476120
51KDM2B_26808549_Chip-Seq_K562_Human1.27543078
52PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.25819722
53TET1_21451524_ChIP-Seq_MESCs_Mouse1.25356914
54KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.25215834
55BCL6_27268052_Chip-Seq_Bcells_Human1.24424576
56ZNF263_19887448_ChIP-Seq_K562_Human1.23833745
57CREB1_26743006_Chip-Seq_LNCaP_Human1.23498881
58GATA2_21666600_ChIP-Seq_HMVEC_Human1.22590128
59CTCF_27219007_Chip-Seq_Bcells_Human1.22500131
60CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.21359969
61NCOR1_26117541_ChIP-Seq_K562_Human1.18025441
62MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.17547549
63CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17459663
64SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.17409817
65DNAJC2_21179169_ChIP-ChIP_NT2_Human1.16379330
66KDM2B_26808549_Chip-Seq_DND41_Human1.16329533
67SOX2_20726797_ChIP-Seq_SW620_Human1.13399270
68GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13191759
69ELF1_20517297_ChIP-Seq_JURKAT_Human1.12268671
70TP63_22573176_ChIP-Seq_HFKS_Human1.12260941
71RARB_27405468_Chip-Seq_BRAIN_Mouse1.11353045
72SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.06833351
73ZFP281_18757296_ChIP-ChIP_E14_Mouse1.06750112
74VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.06550121
75ELK4_26923725_Chip-Seq_MESODERM_Mouse1.06214888
76EZH2_22144423_ChIP-Seq_EOC_Human1.03596116
77Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.01499327
78MTF2_20144788_ChIP-Seq_MESCs_Mouse1.00465049
79ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99838144
80STAT1_20625510_ChIP-Seq_HELA_Human0.99440157
81VDR_24763502_ChIP-Seq_THP-1_Human0.98345031
82SA1_27219007_Chip-Seq_ERYTHROID_Human0.97424190
83CTCF_21964334_ChIP-Seq_BJAB-B_Human0.96695441
84SUZ12_27294783_Chip-Seq_ESCs_Mouse0.95767926
85GATA1_19941827_ChIP-Seq_MEL86_Mouse0.95334352
86RAD21_21589869_ChIP-Seq_MESCs_Mouse0.94337639
87TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94198523
88FOXO3_23340844_ChIP-Seq_DLD1_Human0.93773334
89TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92937191
90NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.92401429
91CTCF_20526341_ChIP-Seq_ESCs_Human0.92299257
92EZH2_27294783_Chip-Seq_ESCs_Mouse0.92261910
93ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.92123480
94GATA2_22383799_ChIP-Seq_G1ME_Mouse0.91102986
95P63_26484246_Chip-Seq_KERATINOCYTES_Human0.91025643
96MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.90036190
97GATA6_25053715_ChIP-Seq_YYC3_Human0.89303973
98SPI1_20517297_ChIP-Seq_HL60_Human0.89131559
99WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.88936761
100E2F1_20622854_ChIP-Seq_HELA_Human0.88217279

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology6.63425257
2MP0008004_abnormal_stomach_pH3.96482717
3MP0005083_abnormal_biliary_tract3.43694600
4MP0003879_abnormal_hair_cell2.99174702
5MP0009780_abnormal_chondrocyte_physiolo2.75262012
6MP0004510_myositis2.65365923
7MP0005058_abnormal_lysosome_morphology2.49489983
8MP0005409_darkened_coat_color2.47845401
9MP0000465_gastrointestinal_hemorrhage2.25672386
10MP0002736_abnormal_nociception_after2.11292605
11MP0003303_peritoneal_inflammation2.01113830
12MP0003638_abnormal_response/metabolism_1.94509523
13MP0005365_abnormal_bile_salt1.92173845
14MP0010329_abnormal_lipoprotein_level1.89664606
15MP0003724_increased_susceptibility_to1.87405871
16MP0004859_abnormal_synaptic_plasticity1.87088327
17MP0001765_abnormal_ion_homeostasis1.85452695
18MP0001968_abnormal_touch/_nociception1.83567504
19MP0010155_abnormal_intestine_physiology1.82724144
20MP0003183_abnormal_peptide_metabolism1.73114198
21MP0001664_abnormal_digestion1.72624839
22MP0002132_abnormal_respiratory_system1.70572420
23MP0003866_abnormal_defecation1.69166633
24MP0000678_abnormal_parathyroid_gland1.67933794
25MP0008872_abnormal_physiological_respon1.65958352
26MP0003566_abnormal_cell_adhesion1.59274020
27MP0000343_altered_response_to1.52546362
28MP0000230_abnormal_systemic_arterial1.50451184
29MP0005646_abnormal_pituitary_gland1.50006305
30MP0001666_abnormal_nutrient_absorption1.48479303
31MP0005167_abnormal_blood-brain_barrier1.46645476
32MP0010234_abnormal_vibrissa_follicle1.45471546
33MP0001663_abnormal_digestive_system1.37448024
34MP0008874_decreased_physiological_sensi1.36069181
35MP0005085_abnormal_gallbladder_physiolo1.34221317
36MP0002796_impaired_skin_barrier1.33459801
37MP0001849_ear_inflammation1.31760771
38MP0008260_abnormal_autophagy1.31390693
39MP0005360_urolithiasis1.30728311
40MP0002089_abnormal_postnatal_growth/wei1.30445170
41MP0005501_abnormal_skin_physiology1.29628459
42MP0009840_abnormal_foam_cell1.28342582
43MP0004947_skin_inflammation1.23529167
44MP0002733_abnormal_thermal_nociception1.23020832
45MP0002139_abnormal_hepatobiliary_system1.22185144
46MP0002118_abnormal_lipid_homeostasis1.21164047
47MP0005666_abnormal_adipose_tissue1.17570133
48MP0003453_abnormal_keratinocyte_physiol1.17502368
49MP0004130_abnormal_muscle_cell1.17078213
50MP0004019_abnormal_vitamin_homeostasis1.15211881
51MP0004084_abnormal_cardiac_muscle1.14328907
52MP0004264_abnormal_extraembryonic_tissu1.10972726
53MP0005381_digestive/alimentary_phenotyp1.09426286
54MP0000249_abnormal_blood_vessel1.09228589
55MP0008569_lethality_at_weaning1.08925551
56MP0004381_abnormal_hair_follicle1.08437901
57MP0008875_abnormal_xenobiotic_pharmacok1.04695097
58MP0004147_increased_porphyrin_level1.03950234
59MP0009643_abnormal_urine_homeostasis1.03570057
60MP0004270_analgesia1.02585978
61MP0001970_abnormal_pain_threshold1.02562552
62MP0003172_abnormal_lysosome_physiology1.01825637
63MP0000383_abnormal_hair_follicle1.01023504
64MP0005670_abnormal_white_adipose0.99772773
65MP0004043_abnormal_pH_regulation0.99334563
66MP0001756_abnormal_urination0.98021765
67MP0005636_abnormal_mineral_homeostasis0.96365352
68MP0009642_abnormal_blood_homeostasis0.95629920
69MP0004036_abnormal_muscle_relaxation0.92857138
70MP0003880_abnormal_central_pattern0.91904322
71MP0002653_abnormal_ependyma_morphology0.91676910
72MP0006138_congestive_heart_failure0.91417602
73MP0008775_abnormal_heart_ventricle0.89212574
74MP0005535_abnormal_body_temperature0.87729282
75MP0005451_abnormal_body_composition0.86924158
76MP0002249_abnormal_larynx_morphology0.86575011
77MP0002098_abnormal_vibrissa_morphology0.86118292
78MP0003705_abnormal_hypodermis_morpholog0.84851368
79MP0005448_abnormal_energy_balance0.84100968
80MP0002064_seizures0.83762849
81MP0003075_altered_response_to0.83359553
82MP0000858_altered_metastatic_potential0.81671755
83MP0002909_abnormal_adrenal_gland0.81317057
84MP0002822_catalepsy0.81108758
85MP0005165_increased_susceptibility_to0.79802449
86MP0010678_abnormal_skin_adnexa0.79800432
87MP0003191_abnormal_cellular_cholesterol0.79669967
88MP0004484_altered_response_of0.79298899
89MP0005423_abnormal_somatic_nervous0.78417673
90MP0002735_abnormal_chemical_nociception0.78002478
91MP0001851_eye_inflammation0.77923131
92MP0003635_abnormal_synaptic_transmissio0.77898205
93MP0005410_abnormal_fertilization0.75040919
94MP0001533_abnormal_skeleton_physiology0.71674619
95MP0005375_adipose_tissue_phenotype0.71475696
96MP0002971_abnormal_brown_adipose0.70376373
97MP0000490_abnormal_crypts_of0.70223030
98MP0000467_abnormal_esophagus_morphology0.70202406
99MP0003436_decreased_susceptibility_to0.69868319
100MP0000579_abnormal_nail_morphology0.69331475

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)8.05207246
2Menorrhagia (HP:0000132)7.77242396
3Increased mean platelet volume (HP:0011877)7.31159177
4Purpura (HP:0000979)7.28153866
5Petechiae (HP:0000967)7.02810977
6Abnormal platelet volume (HP:0011876)6.89241521
7Epistaxis (HP:0000421)5.30646317
8Hyperlipoproteinemia (HP:0010980)4.61375584
9Gingival bleeding (HP:0000225)4.54035013
10Impaired platelet aggregation (HP:0003540)4.07180474
11Abnormal platelet function (HP:0011869)4.07180474
12Abnormal ciliary motility (HP:0012262)3.77099283
13Dynein arm defect of respiratory motile cilia (HP:0012255)3.62596280
14Absent/shortened dynein arms (HP:0200106)3.62596280
15Abnormal respiratory motile cilium morphology (HP:0005938)3.57719646
16Abnormal respiratory epithelium morphology (HP:0012253)3.57719646
17Abnormal respiratory motile cilium physiology (HP:0012261)3.51869115
18Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.51452603
19Acanthocytosis (HP:0001927)3.44077495
20Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.42150957
21Poikilocytosis (HP:0004447)3.11838547
22Ventricular fibrillation (HP:0001663)3.07235492
23Rhinitis (HP:0012384)3.04406054
24Nasal polyposis (HP:0100582)2.96878787
25Xanthomatosis (HP:0000991)2.84887474
26Abnormal pupillary function (HP:0007686)2.72906556
27Male infertility (HP:0003251)2.69090996
28Spontaneous hematomas (HP:0007420)2.68693074
29Dyschromatopsia (HP:0007641)2.59693384
30Abnormality of the nasal mucosa (HP:0000433)2.57856243
31J-shaped sella turcica (HP:0002680)2.57561710
32Hemorrhage of the eye (HP:0011885)2.57195058
33Distal lower limb muscle weakness (HP:0009053)2.49447295
34Hyperactive renin-angiotensin system (HP:0000841)2.48250644
35Bruising susceptibility (HP:0000978)2.43334381
36Ankle clonus (HP:0011448)2.41956006
37Abnormality of lateral ventricle (HP:0030047)2.41042750
38Hyperparathyroidism (HP:0000843)2.40838744
39Hyperthyroidism (HP:0000836)2.36342817
40Thin bony cortex (HP:0002753)2.29847376
41Joint hemorrhage (HP:0005261)2.21400394
42Testicular neoplasm (HP:0010788)2.15464693
43Bronchiectasis (HP:0002110)2.13279039
44Hyporeflexia of lower limbs (HP:0002600)2.12896364
45Chronic bronchitis (HP:0004469)2.12518148
46Infertility (HP:0000789)2.11175919
47Hypophosphatemia (HP:0002148)2.09964320
48Abnormality of the common coagulation pathway (HP:0010990)2.06579219
49Muscle fiber splitting (HP:0003555)2.03614994
50Hepatosplenomegaly (HP:0001433)2.02691191
51Dysostosis multiplex (HP:0000943)2.02033955
52Paralysis (HP:0003470)2.00308090
53Distal lower limb amyotrophy (HP:0008944)1.98816339
54Growth hormone excess (HP:0000845)1.98410309
55Bundle branch block (HP:0011710)1.95315064
56Hypercortisolism (HP:0001578)1.95289964
57Abnormality of macrophages (HP:0004311)1.90969440
58Abnormality of iron homeostasis (HP:0011031)1.89865925
59Obstructive sleep apnea (HP:0002870)1.87995929
60Increased serum ferritin (HP:0003281)1.87829225
61Conjunctival telangiectasia (HP:0000524)1.86181612
62Chronic otitis media (HP:0000389)1.83525674
63Increased density of long bones (HP:0006392)1.82726386
64Insidious onset (HP:0003587)1.80917143
65Termporal pattern (HP:0011008)1.80917143
66Abdominal distention (HP:0003270)1.80040912
67Abnormality of calcium-phosphate metabolism (HP:0100530)1.79453228
68Myokymia (HP:0002411)1.78463169
69Abnormality of glutamine family amino acid metabolism (HP:0010902)1.77961303
70Cholecystitis (HP:0001082)1.76725919
71Abnormal gallbladder physiology (HP:0012438)1.76725919
72Back pain (HP:0003418)1.76112582
73Decreased central vision (HP:0007663)1.75717363
74Increased cerebral lipofuscin (HP:0011813)1.74310146
75Easy fatigability (HP:0003388)1.73026927
76Joint swelling (HP:0001386)1.72853611
77Visual hallucinations (HP:0002367)1.72788399
78Abnormality of the Achilles tendon (HP:0005109)1.72708447
79Increased neuronal autofluorescent lipopigment (HP:0002074)1.71821481
80Tongue fasciculations (HP:0001308)1.71124972
81Abnormality of the heme biosynthetic pathway (HP:0010472)1.71040783
82Atelectasis (HP:0100750)1.68281090
83Diplopia (HP:0000651)1.67741861
84Abnormality of binocular vision (HP:0011514)1.67741861
85Mitral stenosis (HP:0001718)1.67481768
86Adrenal overactivity (HP:0002717)1.66703175
87Generalized aminoaciduria (HP:0002909)1.64256607
88Nausea (HP:0002018)1.62927826
89Abnormality of the vasculature of the conjunctiva (HP:0008054)1.61596940
90Abnormality of renin-angiotensin system (HP:0000847)1.61036955
91Flat acetabular roof (HP:0003180)1.60888611
92Polyphagia (HP:0002591)1.60793966
93Abnormality of transition element cation homeostasis (HP:0011030)1.60089007
94Muscle fibrillation (HP:0010546)1.59438437
95Decreased circulating renin level (HP:0003351)1.59255580
96Reticulocytosis (HP:0001923)1.58852324
97Metabolic alkalosis (HP:0200114)1.58120091
98Neuronal loss in central nervous system (HP:0002529)1.57461482
99Upper limb muscle weakness (HP:0003484)1.57048862
100Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.55322447

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.56853421
2TRIB33.45946439
3BMX3.05142456
4MAPKAPK33.02675966
5MST42.88790134
6EPHA22.45945564
7SIK12.38428804
8MYLK2.28567107
9GRK62.07726729
10PKN22.07258298
11EIF2AK11.90802652
12ILK1.65713626
13MAPK151.64125959
14PTK2B1.54745059
15GRK51.52919528
16LMTK21.48264015
17TESK11.44657958
18PDPK11.43817036
19BTK1.40849315
20MUSK1.37528020
21DAPK21.33138994
22CSF1R1.32174975
23TAOK11.30024820
24TNK21.29937566
25IRAK31.29394918
26RET1.25480658
27RIPK11.25475421
28ERN11.17279228
29CAMKK11.15191373
30MAP3K111.14842895
31ARAF1.11557832
32PDK11.11490065
33MAP2K31.06752033
34ZAP701.06220201
35TAOK21.04922008
36SMG11.03820568
37TESK21.02324342
38SIK31.02003503
39MAP3K30.98515167
40BLK0.97213192
41MINK10.96287867
42PRKD10.94862203
43STK240.94616648
44DAPK30.93938012
45EPHA40.93011491
46CAMK2G0.92101232
47SYK0.92039108
48TEC0.91054956
49MAPK120.90548334
50MAP3K10.88162584
51NTRK30.85910709
52PRPF4B0.85246514
53FGFR40.82065832
54BMPR20.80527854
55MAP2K10.80369783
56MAP3K120.79850726
57RPS6KA20.79806210
58PRKG20.79168408
59CAMK2B0.78417817
60MAP2K20.77726191
61PIM20.77607263
62KSR20.77415690
63PRKCI0.76728705
64MARK20.75924730
65MAP3K20.73884509
66PIK3CA0.72418492
67EEF2K0.70708611
68ERBB20.70471462
69PAK10.70061682
70TAOK30.69404096
71HCK0.68508546
72SIK20.68406908
73DAPK10.67523135
74MST1R0.67086772
75CDC42BPA0.66432877
76RPS6KB20.65512877
77CAMK2D0.64522678
78EPHB10.64437786
79HIPK20.60810086
80EPHA30.60491042
81FGR0.58406497
82ICK0.56929104
83SGK30.52887330
84FER0.52314565
85LRRK20.51885320
86IRAK20.51739891
87NEK60.51681131
88MAP3K60.50043252
89MAP3K50.48889669
90MAP2K60.48695150
91PKN10.48497849
92PTK60.48130273
93PRKD20.47219637
94ROCK10.46438821
95DMPK0.43364992
96MATK0.42733627
97DYRK1B0.41113327
98CSK0.40973771
99ITK0.40052416
100IKBKB0.39695353

Predicted pathways (KEGG)

RankGene SetZ-score
1Platelet activation_Homo sapiens_hsa046113.09021810
2Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.94660771
3Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.94304095
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.81933643
5SNARE interactions in vesicular transport_Homo sapiens_hsa041301.77913165
6Gap junction_Homo sapiens_hsa045401.65031578
7Synaptic vesicle cycle_Homo sapiens_hsa047211.63143186
8Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.53466978
9Cyanoamino acid metabolism_Homo sapiens_hsa004601.48808937
10Collecting duct acid secretion_Homo sapiens_hsa049661.40971933
11Arachidonic acid metabolism_Homo sapiens_hsa005901.40347522
12Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.33511732
13Fat digestion and absorption_Homo sapiens_hsa049751.27621364
14Pancreatic secretion_Homo sapiens_hsa049721.27012754
15Bile secretion_Homo sapiens_hsa049761.24531743
16Serotonergic synapse_Homo sapiens_hsa047261.22334989
17Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.22234415
18Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.21793652
19Circadian entrainment_Homo sapiens_hsa047131.19397491
20Vascular smooth muscle contraction_Homo sapiens_hsa042701.18776619
21Nitrogen metabolism_Homo sapiens_hsa009101.17883353
22Endocytosis_Homo sapiens_hsa041441.17792507
23Sulfur metabolism_Homo sapiens_hsa009201.16924864
24Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.16376587
25Phospholipase D signaling pathway_Homo sapiens_hsa040721.15282353
26Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.14192705
27Choline metabolism in cancer_Homo sapiens_hsa052311.10533770
28Chemokine signaling pathway_Homo sapiens_hsa040621.09556131
29Gastric acid secretion_Homo sapiens_hsa049711.06062099
30Histidine metabolism_Homo sapiens_hsa003401.04715186
31Phosphatidylinositol signaling system_Homo sapiens_hsa040701.04483203
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.04081856
33Vibrio cholerae infection_Homo sapiens_hsa051101.02701080
34Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.02390608
35Leukocyte transendothelial migration_Homo sapiens_hsa046701.02091247
36VEGF signaling pathway_Homo sapiens_hsa043701.00620940
37Glycerolipid metabolism_Homo sapiens_hsa005610.98607421
38Long-term depression_Homo sapiens_hsa047300.97817067
39Glycerophospholipid metabolism_Homo sapiens_hsa005640.94224596
40Long-term potentiation_Homo sapiens_hsa047200.92802827
41Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.92542046
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.91728047
43Carbohydrate digestion and absorption_Homo sapiens_hsa049730.91113427
44Morphine addiction_Homo sapiens_hsa050320.90800147
45Galactose metabolism_Homo sapiens_hsa000520.90189958
46Fructose and mannose metabolism_Homo sapiens_hsa000510.88688424
47Pentose phosphate pathway_Homo sapiens_hsa000300.88387512
48PPAR signaling pathway_Homo sapiens_hsa033200.87035872
49GABAergic synapse_Homo sapiens_hsa047270.86614251
50Chemical carcinogenesis_Homo sapiens_hsa052040.85347851
51Glutathione metabolism_Homo sapiens_hsa004800.85044876
52Cholinergic synapse_Homo sapiens_hsa047250.84868583
53Arginine and proline metabolism_Homo sapiens_hsa003300.84095043
54Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.83907386
55Endometrial cancer_Homo sapiens_hsa052130.83630650
56Starch and sucrose metabolism_Homo sapiens_hsa005000.83328765
57Glutamatergic synapse_Homo sapiens_hsa047240.82882533
58B cell receptor signaling pathway_Homo sapiens_hsa046620.82692418
59Linoleic acid metabolism_Homo sapiens_hsa005910.82176019
60Cocaine addiction_Homo sapiens_hsa050300.81887297
61alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.80131735
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.80009809
63Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.79948346
64Renin secretion_Homo sapiens_hsa049240.79854359
65Amphetamine addiction_Homo sapiens_hsa050310.79177180
66GnRH signaling pathway_Homo sapiens_hsa049120.79108839
67Alcoholism_Homo sapiens_hsa050340.77668098
68Renin-angiotensin system_Homo sapiens_hsa046140.77364882
69Phenylalanine metabolism_Homo sapiens_hsa003600.77182336
70Sphingolipid metabolism_Homo sapiens_hsa006000.76791528
71Glioma_Homo sapiens_hsa052140.75008371
72Aldosterone synthesis and secretion_Homo sapiens_hsa049250.72205787
73ECM-receptor interaction_Homo sapiens_hsa045120.71261039
74Notch signaling pathway_Homo sapiens_hsa043300.71183097
75Insulin secretion_Homo sapiens_hsa049110.68672635
76Estrogen signaling pathway_Homo sapiens_hsa049150.67761019
77Dopaminergic synapse_Homo sapiens_hsa047280.66701510
78Insulin signaling pathway_Homo sapiens_hsa049100.64261399
79Non-small cell lung cancer_Homo sapiens_hsa052230.63808530
80Salivary secretion_Homo sapiens_hsa049700.61465884
81Rap1 signaling pathway_Homo sapiens_hsa040150.60067112
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60043671
83ErbB signaling pathway_Homo sapiens_hsa040120.59648024
84Lysosome_Homo sapiens_hsa041420.59214526
85Oxytocin signaling pathway_Homo sapiens_hsa049210.58667336
86Sulfur relay system_Homo sapiens_hsa041220.58368098
87Tyrosine metabolism_Homo sapiens_hsa003500.56929818
88Glycosaminoglycan degradation_Homo sapiens_hsa005310.56354220
89cGMP-PKG signaling pathway_Homo sapiens_hsa040220.56320637
90Calcium signaling pathway_Homo sapiens_hsa040200.54964396
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54828842
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.54752756
93Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54455741
94Tight junction_Homo sapiens_hsa045300.53198473
95Steroid hormone biosynthesis_Homo sapiens_hsa001400.52523500
96Hematopoietic cell lineage_Homo sapiens_hsa046400.52507938
97Fatty acid elongation_Homo sapiens_hsa000620.52246923
98ABC transporters_Homo sapiens_hsa020100.52138788
99beta-Alanine metabolism_Homo sapiens_hsa004100.51538244
100AMPK signaling pathway_Homo sapiens_hsa041520.51011506

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