MIOS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic sister chromatid cohesion (GO:0007064)5.37416750
2DNA unwinding involved in DNA replication (GO:0006268)4.88503909
3nuclear pore complex assembly (GO:0051292)4.72557567
4nuclear pore organization (GO:0006999)4.69012432
5mitotic nuclear envelope disassembly (GO:0007077)4.26332284
6ribosomal small subunit assembly (GO:0000028)4.25711878
7membrane disassembly (GO:0030397)4.02705192
8nuclear envelope disassembly (GO:0051081)4.02705192
9synapsis (GO:0007129)4.02559033
10mitotic metaphase plate congression (GO:0007080)3.99927191
11nucleobase biosynthetic process (GO:0046112)3.98430447
12regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.93448510
13monoubiquitinated protein deubiquitination (GO:0035520)3.88986146
14ribosome assembly (GO:0042255)3.88575884
15DNA strand elongation involved in DNA replication (GO:0006271)3.85920684
16IMP biosynthetic process (GO:0006188)3.78747811
17CENP-A containing nucleosome assembly (GO:0034080)3.78589411
18DNA replication initiation (GO:0006270)3.76458643
19maturation of SSU-rRNA (GO:0030490)3.75021484
20purine nucleobase biosynthetic process (GO:0009113)3.74420645
21chromatin remodeling at centromere (GO:0031055)3.73210130
22DNA replication-independent nucleosome organization (GO:0034724)3.72075713
23DNA replication-independent nucleosome assembly (GO:0006336)3.72075713
24protein localization to kinetochore (GO:0034501)3.71751466
25DNA strand elongation (GO:0022616)3.69348350
26regulation of spindle organization (GO:0090224)3.69204059
27DNA replication checkpoint (GO:0000076)3.68708124
28formation of translation preinitiation complex (GO:0001731)3.64008893
29mitotic chromosome condensation (GO:0007076)3.61560932
30pre-miRNA processing (GO:0031054)3.59285678
31metaphase plate congression (GO:0051310)3.59205711
32pore complex assembly (GO:0046931)3.57926738
33regulation of sister chromatid segregation (GO:0033045)3.56377639
34regulation of mitotic sister chromatid separation (GO:0010965)3.56377639
35regulation of mitotic sister chromatid segregation (GO:0033047)3.56377639
36histone H2A acetylation (GO:0043968)3.53185822
37non-recombinational repair (GO:0000726)3.52905623
38double-strand break repair via nonhomologous end joining (GO:0006303)3.52905623
39folic acid-containing compound biosynthetic process (GO:0009396)3.52599972
40DNA duplex unwinding (GO:0032508)3.51528292
41DNA geometric change (GO:0032392)3.49523510
42histone exchange (GO:0043486)3.36764098
43protein K6-linked ubiquitination (GO:0085020)3.35745664
44DNA synthesis involved in DNA repair (GO:0000731)3.35435038
45regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.33133193
46negative regulation of DNA repair (GO:0045738)3.31247995
47telomere maintenance via semi-conservative replication (GO:0032201)3.28916614
48somatic diversification of immune receptors via somatic mutation (GO:0002566)3.28783212
49somatic hypermutation of immunoglobulin genes (GO:0016446)3.28783212
50IMP metabolic process (GO:0046040)3.28636693
51regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.27569313
52chromatin assembly or disassembly (GO:0006333)3.26529067
53regulation of RNA export from nucleus (GO:0046831)3.26273614
54positive regulation of mitotic sister chromatid separation (GO:1901970)3.25664587
55positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.25664587
56positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.25664587
57ribosome biogenesis (GO:0042254)3.25520536
58translesion synthesis (GO:0019985)3.24696172
59protein localization to chromosome, centromeric region (GO:0071459)3.24367579
60positive regulation of chromosome segregation (GO:0051984)3.22134280
61mitotic recombination (GO:0006312)3.20386387
62positive regulation of histone H3-K4 methylation (GO:0051571)3.18819857
63regulation of sister chromatid cohesion (GO:0007063)3.18476851
64regulation of centrosome cycle (GO:0046605)3.17507463
65regulation of DNA endoreduplication (GO:0032875)3.17345105
66regulation of centriole replication (GO:0046599)3.17303198
67DNA replication-dependent nucleosome assembly (GO:0006335)3.17258267
68DNA replication-dependent nucleosome organization (GO:0034723)3.17258267
69negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.17133099
70kinetochore organization (GO:0051383)3.17067710
71sister chromatid cohesion (GO:0007062)3.12821945
72somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.11175463
73somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.11175463
74isotype switching (GO:0045190)3.11175463
75telomere maintenance via recombination (GO:0000722)3.10761828
76ribosomal large subunit biogenesis (GO:0042273)3.10198411
77spindle assembly checkpoint (GO:0071173)3.08819617
78regulation of mitotic spindle organization (GO:0060236)3.08506182
79DNA deamination (GO:0045006)3.07939795
80negative regulation of fibroblast apoptotic process (GO:2000270)3.07654609
81sister chromatid segregation (GO:0000819)3.06384050
82regulation of nucleobase-containing compound transport (GO:0032239)3.06144841
83spindle checkpoint (GO:0031577)3.05870172
84nuclear envelope organization (GO:0006998)3.05421518
85mitotic spindle assembly checkpoint (GO:0007094)3.04473710
86alternative mRNA splicing, via spliceosome (GO:0000380)3.04435961
87somatic recombination of immunoglobulin gene segments (GO:0016447)3.04367561
88negative regulation of chromosome segregation (GO:0051985)3.03485765
89negative regulation of mitotic sister chromatid separation (GO:2000816)3.02928832
90negative regulation of mitotic sister chromatid segregation (GO:0033048)3.02928832
91negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.02928832
92negative regulation of sister chromatid segregation (GO:0033046)3.02928832
93rRNA metabolic process (GO:0016072)3.02748568
94mitotic sister chromatid segregation (GO:0000070)3.02412368
95rRNA processing (GO:0006364)3.02346771
96regulation of chromosome segregation (GO:0051983)3.02109116
97negative regulation of RNA splicing (GO:0033119)3.00295264
98response to X-ray (GO:0010165)2.99393115
99attachment of spindle microtubules to kinetochore (GO:0008608)2.97419374
100negative regulation of cell cycle G2/M phase transition (GO:1902750)2.97271226
101mRNA splicing, via spliceosome (GO:0000398)2.96433528
102RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.96433528
103RNA export from nucleus (GO:0006405)2.96094755
104ATP-dependent chromatin remodeling (GO:0043044)2.94697285
105mitochondrial DNA replication (GO:0006264)2.94570658
106RNA splicing, via transesterification reactions (GO:0000375)2.94508178
107histone-serine phosphorylation (GO:0035404)2.94095462
108postreplication repair (GO:0006301)2.93938056
109negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.93894201
110mitotic spindle checkpoint (GO:0071174)2.93718395
111negative regulation of DNA recombination (GO:0045910)2.93212634
112regulation of mitotic metaphase/anaphase transition (GO:0030071)2.93113936
113ribonucleoprotein complex biogenesis (GO:0022613)2.91046732
114DNA conformation change (GO:0071103)2.89202955
115establishment of chromosome localization (GO:0051303)2.88413783
116spliceosomal snRNP assembly (GO:0000387)2.87225746
117regulation of helicase activity (GO:0051095)2.87198919
118regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.86355695
119regulation of histone H3-K9 methylation (GO:0051570)2.84167897
120rRNA catabolic process (GO:0016075)2.84016492
121mitotic G2/M transition checkpoint (GO:0044818)2.83767040
122negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.83343255
123establishment of integrated proviral latency (GO:0075713)2.82744536
124protein localization to chromosome (GO:0034502)2.81678694
125regulation of translational termination (GO:0006449)2.81165501
126regulation of mitotic spindle checkpoint (GO:1903504)2.81108201
127regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.81108201
128DNA topological change (GO:0006265)2.80724949
129regulation of DNA damage checkpoint (GO:2000001)2.80235776
130dosage compensation (GO:0007549)2.79891496
131glucocorticoid receptor signaling pathway (GO:0042921)2.79757904
132negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)2.79388174
133maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.78983882
134piRNA metabolic process (GO:0034587)2.74273361
135mitotic G2 DNA damage checkpoint (GO:0007095)2.73811808
136nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.70841145
137microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.70474326
138peptidyl-lysine dimethylation (GO:0018027)2.69230187
139somatic diversification of immunoglobulins (GO:0016445)2.69185535
140negative regulation of DNA-dependent DNA replication (GO:2000104)2.68574999
141somatic cell DNA recombination (GO:0016444)2.68015618
142somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.68015618

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.66341828
2RBPJ_22232070_ChIP-Seq_NCS_Mouse4.77353906
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.40771223
4FOXM1_23109430_ChIP-Seq_U2OS_Human4.28701936
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.84483252
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.55477876
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.01016619
8CREB1_15753290_ChIP-ChIP_HEK293T_Human2.82451380
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.77770942
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.77507228
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.73108019
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.62793451
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.61864343
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.53247127
15KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.50572295
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.47447806
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.45772735
18E2F1_21310950_ChIP-Seq_MCF-7_Human2.44002808
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.43792807
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.43242973
21ETS1_20019798_ChIP-Seq_JURKAT_Human2.38721694
22AR_21909140_ChIP-Seq_LNCAP_Human2.35222918
23PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.34175436
24MYC_22102868_ChIP-Seq_BL_Human2.29448324
25FOXP3_21729870_ChIP-Seq_TREG_Human2.22012382
26VDR_23849224_ChIP-Seq_CD4+_Human2.21719096
27HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.18502172
28MYCN_18555785_ChIP-Seq_MESCs_Mouse2.16444900
29XRN2_22483619_ChIP-Seq_HELA_Human2.06272995
30CIITA_25753668_ChIP-Seq_RAJI_Human2.05561198
31ZFX_18555785_ChIP-Seq_MESCs_Mouse1.95712169
32YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.95611706
33GABP_19822575_ChIP-Seq_HepG2_Human1.89052188
34FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.84878043
35DCP1A_22483619_ChIP-Seq_HELA_Human1.80190709
36CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.78150196
37ELK1_19687146_ChIP-ChIP_HELA_Human1.74867087
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.74388550
39E2F1_18555785_ChIP-Seq_MESCs_Mouse1.72818215
40* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.70104535
41MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.68997782
42FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.66110576
43E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.63889852
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.63726045
45* KDM5A_27292631_Chip-Seq_BREAST_Human1.60292380
46THAP11_20581084_ChIP-Seq_MESCs_Mouse1.57963931
47NOTCH1_21737748_ChIP-Seq_TLL_Human1.54163718
48* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.54131695
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.53095091
50* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.52607570
51TP63_19390658_ChIP-ChIP_HaCaT_Human1.51735022
52TTF2_22483619_ChIP-Seq_HELA_Human1.51419235
53SALL1_21062744_ChIP-ChIP_HESCs_Human1.51044815
54MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.49706787
55STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.47022605
56ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.45478032
57HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.44314976
58FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.42700133
59PADI4_21655091_ChIP-ChIP_MCF-7_Human1.40796935
60ELF1_17652178_ChIP-ChIP_JURKAT_Human1.38427553
61SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.35203765
62E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.34937538
63WT1_19549856_ChIP-ChIP_CCG9911_Human1.28902833
64CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.26611830
65SRF_21415370_ChIP-Seq_HL-1_Mouse1.26132767
66CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.25739551
67BP1_19119308_ChIP-ChIP_Hs578T_Human1.24782231
68DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.22251253
69* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.21568040
70KLF4_18555785_ChIP-Seq_MESCs_Mouse1.20089147
71FLI1_27457419_Chip-Seq_LIVER_Mouse1.19225048
72ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.19055364
73HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.18277282
74TFEB_21752829_ChIP-Seq_HELA_Human1.18053388
75EWS_26573619_Chip-Seq_HEK293_Human1.17584831
76CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.12882297
77HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.12473464
78NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.10354850
79NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.09806365
80FUS_26573619_Chip-Seq_HEK293_Human1.08205205
81CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.07352598
82NANOG_18555785_ChIP-Seq_MESCs_Mouse1.03520186
83ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.02588044
84GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.01609871
85RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.00855064
86SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.00518866
87FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.99645563
88MYB_21317192_ChIP-Seq_ERMYB_Mouse0.98953726
89* CHD1_26751641_Chip-Seq_LNCaP_Human0.98469945
90BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.98363897
91MYB_26560356_Chip-Seq_TH2_Human0.98038715
92POU3F2_20337985_ChIP-ChIP_501MEL_Human0.97278186
93BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.97276408
94DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.96706627
95CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.96467090
96STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.96330947
97NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.96077422
98SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.93236559
99IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.92928669
100PCGF2_27294783_Chip-Seq_ESCs_Mouse0.90335561
101SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.88536408
102YY1_21170310_ChIP-Seq_MESCs_Mouse0.88493345
103NANOG_21062744_ChIP-ChIP_HESCs_Human0.88459516
104VDR_21846776_ChIP-Seq_THP-1_Human0.88154457
105GATA4_21415370_ChIP-Seq_HL-1_Mouse0.87527382
106POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.86639081
107FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.86271930
108IRF8_22096565_ChIP-ChIP_GC-B_Human0.85608219
109PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.85196007
110SPI1_23547873_ChIP-Seq_NB4_Human0.85136665
111GATA1_22025678_ChIP-Seq_K562_Human0.83237923
112RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.82568473
113TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81926437
114CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.81829640
115MYC_18940864_ChIP-ChIP_HL60_Human0.81227033
116POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.81193648
117TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.81172357
118PU_27001747_Chip-Seq_BMDM_Mouse0.81170218
119TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.79550138
120MYB_26560356_Chip-Seq_TH1_Human0.79501006
121* ELK1_22589737_ChIP-Seq_MCF10A_Human0.76586255
122TCF7_22412390_ChIP-Seq_EML_Mouse0.75894162
123GATA1_22383799_ChIP-Seq_G1ME_Mouse0.75062246
124STAT3_1855785_ChIP-Seq_MESCs_Mouse0.73700897
125UTX_26944678_Chip-Seq_JUKART_Human0.73117501
126SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.72756021

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.75037078
2MP0010094_abnormal_chromosome_stability4.15870562
3MP0004957_abnormal_blastocyst_morpholog3.98378946
4MP0008057_abnormal_DNA_replication3.90564935
5MP0003111_abnormal_nucleus_morphology3.78522023
6MP0003077_abnormal_cell_cycle3.73090969
7MP0002396_abnormal_hematopoietic_system3.53464705
8MP0003123_paternal_imprinting3.33648091
9MP0008058_abnormal_DNA_repair2.96869295
10MP0008877_abnormal_DNA_methylation2.89575284
11MP0002009_preneoplasia2.65696132
12MP0008007_abnormal_cellular_replicative2.44636223
13MP0010307_abnormal_tumor_latency2.43042677
14MP0001730_embryonic_growth_arrest2.42068116
15MP0003941_abnormal_skin_development2.40346646
16MP0004808_abnormal_hematopoietic_stem2.24416524
17MP0004145_abnormal_muscle_electrophysio2.20279724
18MP0008932_abnormal_embryonic_tissue2.13474607
19MP0000350_abnormal_cell_proliferation2.11022971
20MP0000569_abnormal_digit_pigmentation2.02823301
21MP0005451_abnormal_body_composition1.93148054
22MP0010234_abnormal_vibrissa_follicle1.86228353
23MP0001672_abnormal_embryogenesis/_devel1.83333258
24MP0005380_embryogenesis_phenotype1.83333258
25MP0003121_genomic_imprinting1.78592410
26MP0006054_spinal_hemorrhage1.78347671
27MP0003567_abnormal_fetal_cardiomyocyte1.74431480
28MP0001697_abnormal_embryo_size1.73955345
29MP0003984_embryonic_growth_retardation1.73318682
30MP0002088_abnormal_embryonic_growth/wei1.72433781
31MP0010352_gastrointestinal_tract_polyps1.69790757
32MP0003950_abnormal_plasma_membrane1.69775803
33MP0003221_abnormal_cardiomyocyte_apopto1.67779309
34MP0001545_abnormal_hematopoietic_system1.64725952
35MP0005397_hematopoietic_system_phenotyp1.64725952
36MP0009278_abnormal_bone_marrow1.63978306
37MP0002080_prenatal_lethality1.62284074
38MP0002086_abnormal_extraembryonic_tissu1.59277102
39MP0002234_abnormal_pharynx_morphology1.59183160
40MP0002877_abnormal_melanocyte_morpholog1.55888936
41MP0000703_abnormal_thymus_morphology1.49341441
42MP0004197_abnormal_fetal_growth/weight/1.49244400
43MP0003763_abnormal_thymus_physiology1.47588518
44MP0002084_abnormal_developmental_patter1.45978983
45MP0000313_abnormal_cell_death1.37532544
46MP0002019_abnormal_tumor_incidence1.37514457
47MP0003787_abnormal_imprinting1.36305633
48MP0010678_abnormal_skin_adnexa1.33915199
49MP0002210_abnormal_sex_determination1.29817046
50MP0002085_abnormal_embryonic_tissue1.29725396
51MP0000490_abnormal_crypts_of1.29320109
52MP0001929_abnormal_gametogenesis1.24561980
53MP0001145_abnormal_male_reproductive1.23659646
54MP0003786_premature_aging1.18571341
55MP0000749_muscle_degeneration1.17704076
56MP0004087_abnormal_muscle_fiber1.16773107
57MP0002398_abnormal_bone_marrow1.16183856
58MP0004185_abnormal_adipocyte_glucose1.15377406
59MP0002166_altered_tumor_susceptibility1.14767593
60MP0002138_abnormal_hepatobiliary_system1.14216741
61MP0004233_abnormal_muscle_weight1.14124155
62MP0002653_abnormal_ependyma_morphology1.13852393
63MP0004084_abnormal_cardiac_muscle1.10219788
64MP0002722_abnormal_immune_system1.10213116
65MP0003315_abnormal_perineum_morphology1.09924602
66MP0000689_abnormal_spleen_morphology1.06771500
67MP0000653_abnormal_sex_gland1.06481865
68MP0000383_abnormal_hair_follicle1.05959870
69MP0009672_abnormal_birth_weight1.05594390
70MP0000759_abnormal_skeletal_muscle1.04645438
71MP0005187_abnormal_penis_morphology1.01964686
72MP0009697_abnormal_copulation1.00799583
73MP0002106_abnormal_muscle_physiology0.98547691
74MP0003718_maternal_effect0.97776919
75MP0001293_anophthalmia0.96710645
76MP0006035_abnormal_mitochondrial_morpho0.95125460
77MP0000465_gastrointestinal_hemorrhage0.94416205
78MP0005266_abnormal_metabolism0.93517571
79MP0002332_abnormal_exercise_endurance0.91506769
80MP0006036_abnormal_mitochondrial_physio0.91477813
81MP0005076_abnormal_cell_differentiation0.90732140
82MP0005310_abnormal_salivary_gland0.90485610
83MP0003806_abnormal_nucleotide_metabolis0.90021378
84MP0009333_abnormal_splenocyte_physiolog0.89874018
85MP0002796_impaired_skin_barrier0.89282735
86MP0002095_abnormal_skin_pigmentation0.88640225
87MP0009703_decreased_birth_body0.87622667
88MP0003119_abnormal_digestive_system0.86403471
89MP0003656_abnormal_erythrocyte_physiolo0.84890928
90MP0001800_abnormal_humoral_immune0.81542633
91MP0001835_abnormal_antigen_presentation0.80869332
92MP0003698_abnormal_male_reproductive0.80440589
93MP0005384_cellular_phenotype0.80286917
94MP0005220_abnormal_exocrine_pancreas0.79808740
95MP0000428_abnormal_craniofacial_morphol0.79571815
96MP0003646_muscle_fatigue0.79186676
97MP0000537_abnormal_urethra_morphology0.77958742
98MP0000358_abnormal_cell_content/0.77342629
99MP0005621_abnormal_cell_physiology0.76450082
100MP0005408_hypopigmentation0.76267470
101MP0002006_tumorigenesis0.76225426
102MP0001119_abnormal_female_reproductive0.76129894
103MP0006292_abnormal_olfactory_placode0.75829142
104MP0002429_abnormal_blood_cell0.75571141
105MP0000266_abnormal_heart_morphology0.73797606
106MP0005330_cardiomyopathy0.72060434
107MP0003699_abnormal_female_reproductive0.71977223
108MP0000427_abnormal_hair_cycle0.71342157
109MP0002452_abnormal_antigen_presenting0.69444684
110MP0005369_muscle_phenotype0.69294495
111MP0003115_abnormal_respiratory_system0.67331514
112MP0000377_abnormal_hair_follicle0.67124749
113MP0002254_reproductive_system_inflammat0.67047109
114MP0002161_abnormal_fertility/fecundity0.66660111
115MP0002075_abnormal_coat/hair_pigmentati0.66377668
116MP0005389_reproductive_system_phenotype0.66252829
117MP0000685_abnormal_immune_system0.65465534
118MP0000733_abnormal_muscle_development0.64955380
119MP0000371_diluted_coat_color0.64321042
120MP0003890_abnormal_embryonic-extraembry0.63850781
121MP0003935_abnormal_craniofacial_develop0.63499800
122MP0003453_abnormal_keratinocyte_physiol0.63305508
123MP0002269_muscular_atrophy0.62662786
124MP0002938_white_spotting0.62484054
125MP0001919_abnormal_reproductive_system0.62028211
126MP0000716_abnormal_immune_system0.61969371
127MP0010630_abnormal_cardiac_muscle0.61171211
128MP0005501_abnormal_skin_physiology0.59780164
129MP0009053_abnormal_anal_canal0.59180002
130MP0003943_abnormal_hepatobiliary_system0.57892409
131MP0000747_muscle_weakness0.57063780
132MP0003937_abnormal_limbs/digits/tail_de0.57028974
133MP0001661_extended_life_span0.56755247
134MP0004036_abnormal_muscle_relaxation0.56544629
135MP0003868_abnormal_feces_composition0.55509696
136MP0005075_abnormal_melanosome_morpholog0.54633874

Predicted human phenotypes

RankGene SetZ-score
1Nemaline bodies (HP:0003798)4.86502004
2Muscle fiber inclusion bodies (HP:0100299)4.83088909
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.73064159
4Volvulus (HP:0002580)4.35517426
5Thrombocytosis (HP:0001894)4.11127967
6Birth length less than 3rd percentile (HP:0003561)4.00795671
7Chromosomal breakage induced by crosslinking agents (HP:0003221)3.85845305
8Hypoplasia of the pons (HP:0012110)3.70283614
9IgM deficiency (HP:0002850)3.57336213
10Exercise-induced muscle cramps (HP:0003710)3.56362091
11Colon cancer (HP:0003003)3.51246688
12Pelvic girdle muscle weakness (HP:0003749)3.48207007
13Aplastic anemia (HP:0001915)3.45578756
14Microvesicular hepatic steatosis (HP:0001414)3.25469066
15Abnormality of the pons (HP:0007361)3.07083251
16Ependymoma (HP:0002888)3.06673215
17Shoulder girdle muscle weakness (HP:0003547)3.00371804
18Abnormality of cells of the erythroid lineage (HP:0012130)2.97824606
19Abnormality of the hip-girdle musculature (HP:0001445)2.90243034
20Abnormality of the musculature of the pelvis (HP:0001469)2.90243034
21High pitched voice (HP:0001620)2.90138167
22B lymphocytopenia (HP:0010976)2.88883116
23Medulloblastoma (HP:0002885)2.87006791
24Prominent nose (HP:0000448)2.82141572
25Selective tooth agenesis (HP:0001592)2.80436047
26Cystic hygroma (HP:0000476)2.76722615
27Progressive external ophthalmoplegia (HP:0000590)2.72932711
28Nephroblastoma (Wilms tumor) (HP:0002667)2.70532631
29Exercise-induced myalgia (HP:0003738)2.70449959
30Agnosia (HP:0010524)2.69473899
31Progressive muscle weakness (HP:0003323)2.68608671
32Abnormality of the anterior horn cell (HP:0006802)2.68374019
33Degeneration of anterior horn cells (HP:0002398)2.68374019
34Oral leukoplakia (HP:0002745)2.65521626
35Acute myeloid leukemia (HP:0004808)2.65098128
36Gonadotropin excess (HP:0000837)2.64268196
37IgA deficiency (HP:0002720)2.63553002
38Abnormal number of erythroid precursors (HP:0012131)2.63391085
39Rimmed vacuoles (HP:0003805)2.62827328
40Abnormality of chromosome stability (HP:0003220)2.58177866
41Premature graying of hair (HP:0002216)2.52448553
42Type 1 muscle fiber predominance (HP:0003803)2.50833019
43Abnormality of B cell number (HP:0010975)2.50353921
44Proximal placement of thumb (HP:0009623)2.49225740
45Embryonal renal neoplasm (HP:0011794)2.48223897
46Basal cell carcinoma (HP:0002671)2.47523349
47Poikiloderma (HP:0001029)2.47346996
48Rhabdomyolysis (HP:0003201)2.46979252
49Myoglobinuria (HP:0002913)2.43315258
50Long eyelashes (HP:0000527)2.42093697
51Abnormal hair whorl (HP:0010721)2.40877979
52Deep philtrum (HP:0002002)2.40545532
53Glioma (HP:0009733)2.40023021
54Central scotoma (HP:0000603)2.39771460
55Entropion (HP:0000621)2.38817498
56Cortical dysplasia (HP:0002539)2.38366186
57Deviation of the thumb (HP:0009603)2.37940572
58Rhabdomyosarcoma (HP:0002859)2.37047070
59Abnormality of the fingertips (HP:0001211)2.35872259
60Distal arthrogryposis (HP:0005684)2.34706829
61Myelodysplasia (HP:0002863)2.33647769
62Abnormality of the astrocytes (HP:0100707)2.33049826
63Astrocytoma (HP:0009592)2.33049826
64Centrally nucleated skeletal muscle fibers (HP:0003687)2.31888590
6511 pairs of ribs (HP:0000878)2.31485273
66Termporal pattern (HP:0011008)2.30517781
67Insidious onset (HP:0003587)2.30517781
68Atrophy/Degeneration involving motor neurons (HP:0007373)2.28873652
69Combined immunodeficiency (HP:0005387)2.28473305
70T lymphocytopenia (HP:0005403)2.27353140
71Facial hemangioma (HP:0000329)2.26336059
72Neoplasm of the adrenal cortex (HP:0100641)2.21722856
73Amyotrophic lateral sclerosis (HP:0007354)2.21423703
74Heterotopia (HP:0002282)2.17796325
75Impulsivity (HP:0100710)2.15653834
76Slender long bone (HP:0003100)2.14494976
77Neoplasm of the pancreas (HP:0002894)2.12719841
78Rough bone trabeculation (HP:0100670)2.12251223
79Squamous cell carcinoma (HP:0002860)2.08639126
80Muscle hypertrophy of the lower extremities (HP:0008968)2.08476015
81Acute lymphatic leukemia (HP:0006721)2.07759323
82Macroorchidism (HP:0000053)2.06987207
83Poor head control (HP:0002421)2.06848866
84Papillary thyroid carcinoma (HP:0002895)2.06166479
85Calf muscle hypertrophy (HP:0008981)2.06162449
86Enlarged penis (HP:0000040)2.05443996
87Renal cortical cysts (HP:0000803)2.04274975
88Abnormal spermatogenesis (HP:0008669)2.03244517
89Cafe-au-lait spot (HP:0000957)2.02851962
90Patellar aplasia (HP:0006443)2.00761292
91Reticulocytopenia (HP:0001896)2.00631436
92Aortic aneurysm (HP:0004942)1.99636369
93Aplasia/Hypoplasia of the uvula (HP:0010293)1.99617924
94Abnormality of the left ventricular outflow tract (HP:0011103)1.98949669
95Subaortic stenosis (HP:0001682)1.98949669
96Breast carcinoma (HP:0003002)1.97774638
97Multiple enchondromatosis (HP:0005701)1.97494319
98Prostate neoplasm (HP:0100787)1.94107010
99Increased nuchal translucency (HP:0010880)1.93483878
100Neoplasm of striated muscle (HP:0009728)1.93276333
101Biliary tract neoplasm (HP:0100574)1.93255536
102Agammaglobulinemia (HP:0004432)1.92108863
103Small intestinal stenosis (HP:0012848)1.91950040
104Duodenal stenosis (HP:0100867)1.91950040
105Cutaneous melanoma (HP:0012056)1.91697694
106Abnormality of T cell number (HP:0011839)1.90716664
107Ulnar deviation of the wrist (HP:0003049)1.90210803
108Chromsome breakage (HP:0040012)1.89454128
109Abnormal finger flexion creases (HP:0006143)1.89281870
110Absent frontal sinuses (HP:0002688)1.87215081
111Abnormality of the calcaneus (HP:0008364)1.87181191
112Truncal obesity (HP:0001956)1.86625136
113Spondylolisthesis (HP:0003302)1.86466827
114Meckel diverticulum (HP:0002245)1.86125069
115Aplasia/Hypoplasia of the patella (HP:0006498)1.86107211
116Premature ovarian failure (HP:0008209)1.85558651
117Sloping forehead (HP:0000340)1.84931191
118Hypoplasia of the capital femoral epiphysis (HP:0003090)1.84213893
119Abnormality of the lower motor neuron (HP:0002366)1.84212556
120Ankle contracture (HP:0006466)1.83705571
121Thyroid carcinoma (HP:0002890)1.82201470
122Lymphoma (HP:0002665)1.80975439
123Carpal bone hypoplasia (HP:0001498)1.80388146
124Clubbing of toes (HP:0100760)1.79948433
125Abnormal biliary tract morphology (HP:0012440)1.79723120
126Limb-girdle muscle weakness (HP:0003325)1.79111878
127Panhypogammaglobulinemia (HP:0003139)1.78871683
128Anal stenosis (HP:0002025)1.78863024
129Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.78683069
130Abnormality of alanine metabolism (HP:0010916)1.78683069
131Hyperalaninemia (HP:0003348)1.78683069
132Dysmetric saccades (HP:0000641)1.77980011
133Abnormality of the salivary glands (HP:0010286)1.76998048
134Neoplasm of the small intestine (HP:0100833)1.76872920
135Neoplasm of the colon (HP:0100273)1.76192846
136Absent phalangeal crease (HP:0006109)1.76085788
137Aplasia/Hypoplasia of the sternum (HP:0006714)1.75656044
138Abnormality of the labia minora (HP:0012880)1.75524793
139Missing ribs (HP:0000921)1.74586082
140Macrocytic anemia (HP:0001972)1.74152595
141Recurrent bronchitis (HP:0002837)1.73912857
142Cellular immunodeficiency (HP:0005374)1.73430115
143Abnormality of the preputium (HP:0100587)1.73092620
144Curly hair (HP:0002212)1.72643716
145Short 4th metacarpal (HP:0010044)1.72289026
146Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.72289026
147Long clavicles (HP:0000890)1.71467410
148Abnormality of the ileum (HP:0001549)1.70226341
149Recurrent viral infections (HP:0004429)1.70054773
150Gastrointestinal stroma tumor (HP:0100723)1.69830732
151Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.69047840
152Secondary amenorrhea (HP:0000869)1.68302486
153Abnormality of the heme biosynthetic pathway (HP:0010472)1.67548922
154Atresia of the external auditory canal (HP:0000413)1.67487715
155Impaired vibration sensation in the lower limbs (HP:0002166)1.67248978
156Gastrointestinal carcinoma (HP:0002672)1.67199475
157Malignant gastrointestinal tract tumors (HP:0006749)1.67199475
158Protrusio acetabuli (HP:0003179)1.66698252
159Malignant hyperthermia (HP:0002047)1.65680512
160EMG: myopathic abnormalities (HP:0003458)1.64469344
161Glossoptosis (HP:0000162)1.64381526
162Abnormality of the duodenum (HP:0002246)1.63645956
163Blepharitis (HP:0000498)1.63450054
164Chronic diarrhea (HP:0002028)1.62614761

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.27874787
2MAP3K43.76972856
3BMPR1B3.69856098
4EIF2AK13.65138640
5OBSCN3.14334705
6WEE13.05194528
7MAP2K72.84727033
8EIF2AK32.49346714
9BUB12.48554889
10FLT32.43978156
11NEK22.36714908
12MUSK2.35092292
13PKN22.32498502
14EEF2K2.26902926
15NEK92.08670130
16PASK2.08294556
17SCYL21.99147707
18CDK81.89649931
19CDK191.83104613
20LATS11.78523207
21RPS6KA41.78243560
22CCNB11.77543092
23CAMK1D1.76154854
24TGFBR11.72671202
25DYRK31.70170570
26ATR1.68255891
27PBK1.67965158
28TTK1.67639527
29STK241.61785868
30CDK31.54909605
31AURKB1.51380562
32CDK121.51370119
33PLK11.49860199
34RAF11.44031867
35CDK41.41570217
36PLK31.39786243
37ZAK1.37876883
38MAP3K141.37763801
39TSSK61.37474791
40NEK11.34922474
41TAF11.34899947
42CDK71.34069218
43PLK41.31109831
44MST41.30679534
45RPS6KB21.29148834
46MAP2K41.26355534
47PDK41.23910783
48PDK31.23910783
49STK161.17247712
50SRPK11.16783437
51CHEK11.15095221
52TESK21.13965120
53BRSK21.12177053
54MAP3K131.10755716
55MAP3K81.09696923
56MKNK11.09542316
57STK38L1.07968975
58STK31.06961976
59AKT31.06486521
60ATM1.05154098
61STK101.04856908
62VRK11.04319512
63CHEK21.03486573
64BRAF0.98790026
65MAP4K10.97091733
66MAP3K100.91976573
67NME20.91444404
68CAMK1G0.91138083
69BMPR20.90382597
70ERBB30.89527325
71CDK20.89026524
72RET0.88444266
73TTN0.87593474
74CAMKK20.85722736
75CDK90.84490114
76ACVR1B0.83146927
77RPS6KB10.83057158
78PRPF4B0.82651542
79PIK3CG0.79670718
80NUAK10.77450016
81MKNK20.76793385
82MOS0.76576686
83TEC0.75172076
84ERBB40.73177957
85STK40.67213976
86PINK10.67054174
87MAP3K90.62824760
88CDK10.62820763
89PIM10.60491423
90ALK0.59940840
91AURKA0.58736048
92MTOR0.58478891
93MELK0.56793166
94CSNK2A20.56482694
95NME10.56098268
96PIM20.53857064
97CSNK1G30.51552886
98DMPK0.49662565
99PAK20.49450944
100CSNK1A1L0.49114008
101MAP3K50.47681337
102CSNK1G10.47372793
103JAK30.47315954
104BCR0.47300999
105LATS20.45360797
106CSNK2A10.44102211
107RPS6KA50.44022939
108BRD40.43064903
109CLK10.42662032
110PRKDC0.42118594
111EIF2AK20.42011001
112PDK20.40700674
113SGK20.39780260
114TLK10.38804196
115SGK30.38633019
116LRRK20.37309560
117PNCK0.37253897
118CDK60.36595520
119CSNK1E0.36576888
120RIPK40.36183761
121BRSK10.35738673
122BTK0.34667011
123ZAP700.33616861
124KSR10.32996641
125MAPK140.32613694
126PRKAA10.31818650
127CSF1R0.30541646
128AKT20.29955451
129TRIB30.29651487
130TYK20.26746255
131MAPK100.26489594
132FRK0.23433898
133MAPK90.22958641

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.33823064
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.78853476
3Mismatch repair_Homo sapiens_hsa034303.71870981
4RNA transport_Homo sapiens_hsa030133.43886565
5Spliceosome_Homo sapiens_hsa030403.04566616
6Cell cycle_Homo sapiens_hsa041103.02324118
7RNA polymerase_Homo sapiens_hsa030202.77692461
8Homologous recombination_Homo sapiens_hsa034402.66635181
9Nucleotide excision repair_Homo sapiens_hsa034202.53939702
10Base excision repair_Homo sapiens_hsa034102.52215299
11Non-homologous end-joining_Homo sapiens_hsa034502.43755983
12Basal transcription factors_Homo sapiens_hsa030222.31513372
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.31162670
14Ribosome_Homo sapiens_hsa030102.29663673
15RNA degradation_Homo sapiens_hsa030182.27764078
16mRNA surveillance pathway_Homo sapiens_hsa030152.27086830
17Proteasome_Homo sapiens_hsa030502.14873880
18Pyrimidine metabolism_Homo sapiens_hsa002402.06007532
19Fanconi anemia pathway_Homo sapiens_hsa034602.01782851
20One carbon pool by folate_Homo sapiens_hsa006702.00168792
21p53 signaling pathway_Homo sapiens_hsa041151.66692767
22Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.40046402
23Oocyte meiosis_Homo sapiens_hsa041141.37495122
24Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.35195922
25Purine metabolism_Homo sapiens_hsa002301.29682817
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.27648163
27Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.23111023
28Herpes simplex infection_Homo sapiens_hsa051681.21646446
29Epstein-Barr virus infection_Homo sapiens_hsa051691.21432986
30Systemic lupus erythematosus_Homo sapiens_hsa053221.16549281
31Propanoate metabolism_Homo sapiens_hsa006401.13507316
32Antigen processing and presentation_Homo sapiens_hsa046121.11661753
33Colorectal cancer_Homo sapiens_hsa052101.07936793
34Viral myocarditis_Homo sapiens_hsa054161.07195639
35Thyroid cancer_Homo sapiens_hsa052161.06884623
36Selenocompound metabolism_Homo sapiens_hsa004501.05894222
37Vitamin B6 metabolism_Homo sapiens_hsa007501.05687711
38Intestinal immune network for IgA production_Homo sapiens_hsa046721.03535279
39Viral carcinogenesis_Homo sapiens_hsa052031.02225042
40Pentose phosphate pathway_Homo sapiens_hsa000301.01047435
41HTLV-I infection_Homo sapiens_hsa051660.88762975
42Cysteine and methionine metabolism_Homo sapiens_hsa002700.88661103
43Asthma_Homo sapiens_hsa053100.84845334
44MicroRNAs in cancer_Homo sapiens_hsa052060.84185974
45Folate biosynthesis_Homo sapiens_hsa007900.84114770
46Biosynthesis of amino acids_Homo sapiens_hsa012300.83275888
47N-Glycan biosynthesis_Homo sapiens_hsa005100.83235013
48Renal cell carcinoma_Homo sapiens_hsa052110.80650187
49NF-kappa B signaling pathway_Homo sapiens_hsa040640.79958439
50Lysine degradation_Homo sapiens_hsa003100.78246785
51Allograft rejection_Homo sapiens_hsa053300.75595675
52Chronic myeloid leukemia_Homo sapiens_hsa052200.72599978
53Acute myeloid leukemia_Homo sapiens_hsa052210.71622789
54Protein export_Homo sapiens_hsa030600.71114056
55Hepatitis B_Homo sapiens_hsa051610.69537287
56mTOR signaling pathway_Homo sapiens_hsa041500.69347759
57FoxO signaling pathway_Homo sapiens_hsa040680.68697132
58Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67081062
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65618769
60Adherens junction_Homo sapiens_hsa045200.63588947
61Circadian rhythm_Homo sapiens_hsa047100.63380805
62Alcoholism_Homo sapiens_hsa050340.62657224
63Non-small cell lung cancer_Homo sapiens_hsa052230.60546191
64Central carbon metabolism in cancer_Homo sapiens_hsa052300.60452787
65Primary immunodeficiency_Homo sapiens_hsa053400.59022472
66Influenza A_Homo sapiens_hsa051640.58084109
67Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.57990223
68Autoimmune thyroid disease_Homo sapiens_hsa053200.57597201
69Pancreatic cancer_Homo sapiens_hsa052120.56928891
70Small cell lung cancer_Homo sapiens_hsa052220.56540248
71T cell receptor signaling pathway_Homo sapiens_hsa046600.56539425
72Carbon metabolism_Homo sapiens_hsa012000.55754868
73Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.55296305
74Graft-versus-host disease_Homo sapiens_hsa053320.49368221
75TGF-beta signaling pathway_Homo sapiens_hsa043500.49213202
76Wnt signaling pathway_Homo sapiens_hsa043100.47522466
77AMPK signaling pathway_Homo sapiens_hsa041520.46754205
78Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.46470388
79Bladder cancer_Homo sapiens_hsa052190.45334814
80Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45193402
812-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.44037701
82Insulin resistance_Homo sapiens_hsa049310.43162482
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43127066
84Prolactin signaling pathway_Homo sapiens_hsa049170.42917016
85HIF-1 signaling pathway_Homo sapiens_hsa040660.42808786
86B cell receptor signaling pathway_Homo sapiens_hsa046620.42490862
87Inositol phosphate metabolism_Homo sapiens_hsa005620.41919980
88Shigellosis_Homo sapiens_hsa051310.41878735
89Endometrial cancer_Homo sapiens_hsa052130.41435449
90Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.40447465
91RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.40054236
92Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.39762130
93Long-term depression_Homo sapiens_hsa047300.39550566
94Jak-STAT signaling pathway_Homo sapiens_hsa046300.39129807
95Drug metabolism - other enzymes_Homo sapiens_hsa009830.39105295
96Insulin signaling pathway_Homo sapiens_hsa049100.38046429
97Phosphatidylinositol signaling system_Homo sapiens_hsa040700.37522968
98Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.37496451
99Pathways in cancer_Homo sapiens_hsa052000.36375263
100Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.36193711
101Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.36041282
102Toxoplasmosis_Homo sapiens_hsa051450.35570042
103Neurotrophin signaling pathway_Homo sapiens_hsa047220.34705129
104Leishmaniasis_Homo sapiens_hsa051400.34598018
105Type I diabetes mellitus_Homo sapiens_hsa049400.34414337
106Toll-like receptor signaling pathway_Homo sapiens_hsa046200.34089426
107Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.31523242
108Glucagon signaling pathway_Homo sapiens_hsa049220.30794091
109Apoptosis_Homo sapiens_hsa042100.30669976
110Melanoma_Homo sapiens_hsa052180.29490479
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28873744
112Prostate cancer_Homo sapiens_hsa052150.27416689
113Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.26881980
114Legionellosis_Homo sapiens_hsa051340.26355664
115Hippo signaling pathway_Homo sapiens_hsa043900.25787704
116Dorso-ventral axis formation_Homo sapiens_hsa043200.24812720
117NOD-like receptor signaling pathway_Homo sapiens_hsa046210.24767381
118ErbB signaling pathway_Homo sapiens_hsa040120.24326376
119Hematopoietic cell lineage_Homo sapiens_hsa046400.22419258
120Fructose and mannose metabolism_Homo sapiens_hsa000510.21963436
121Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.21941694
122Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.21285995
123PI3K-Akt signaling pathway_Homo sapiens_hsa041510.19692557
124Maturity onset diabetes of the young_Homo sapiens_hsa049500.19306286
125Pyruvate metabolism_Homo sapiens_hsa006200.18445083
126Measles_Homo sapiens_hsa051620.17746496
127Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.17544147
128Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.17424984

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