MINOS1P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cAMP-mediated signaling (GO:0043951)8.29631226
2inner mitochondrial membrane organization (GO:0007007)7.21433751
3piRNA metabolic process (GO:0034587)6.80276143
4opioid receptor signaling pathway (GO:0038003)5.81677197
5behavioral response to ethanol (GO:0048149)5.56851799
6cilium or flagellum-dependent cell motility (GO:0001539)5.54381002
7ether lipid metabolic process (GO:0046485)5.53510180
8sphingosine metabolic process (GO:0006670)5.47028411
9ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043165.16080049
10negative regulation of calcium ion-dependent exocytosis (GO:0045955)5.09391597
11response to dietary excess (GO:0002021)5.00059338
12positive regulation of cAMP-mediated signaling (GO:0043950)4.98437143
13sphingoid metabolic process (GO:0046519)4.86160414
14diol metabolic process (GO:0034311)4.84607436
15adult feeding behavior (GO:0008343)4.83271337
16protein insertion into membrane (GO:0051205)4.81770020
17adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)4.57343023
18regulation of acrosome reaction (GO:0060046)4.54697834
19thyroid hormone generation (GO:0006590)4.47815183
20UDP-N-acetylglucosamine metabolic process (GO:0006047)4.42767749
21somite development (GO:0061053)4.26936874
22nucleotide transmembrane transport (GO:1901679)4.23959899
23regulation of protein glycosylation (GO:0060049)4.22446980
24dendritic spine morphogenesis (GO:0060997)4.09132376
25cellular ketone body metabolic process (GO:0046950)4.08659554
26membrane depolarization during action potential (GO:0086010)4.04872047
27protein localization to synapse (GO:0035418)4.01065196
28thyroid hormone metabolic process (GO:0042403)3.94003341
29regulation of DNA endoreduplication (GO:0032875)3.86946118
30DNA replication-dependent nucleosome assembly (GO:0006335)3.83883960
31DNA replication-dependent nucleosome organization (GO:0034723)3.83883960
32cornea development in camera-type eye (GO:0061303)3.81642778
33ribonucleoprotein complex disassembly (GO:0032988)3.76327752
34regulation of translational termination (GO:0006449)3.74993112
35mRNA cleavage (GO:0006379)3.71893239
36regulation of glutamate receptor signaling pathway (GO:1900449)3.64847442
37membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.64444436
38regulation of cAMP-mediated signaling (GO:0043949)3.64033412
39prepulse inhibition (GO:0060134)3.63143448
40ketone body metabolic process (GO:1902224)3.61635866
41viral mRNA export from host cell nucleus (GO:0046784)3.50615763
42negative regulation of nitric oxide biosynthetic process (GO:0045019)3.44270104
43regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.41377547
44spinal cord development (GO:0021510)3.35430046
45glycerol ether metabolic process (GO:0006662)3.34510707
46negative regulation of DNA-dependent DNA replication (GO:2000104)3.30929800
47phenol-containing compound catabolic process (GO:0019336)3.25012437
48synaptic transmission, glutamatergic (GO:0035249)3.17116284
49ether metabolic process (GO:0018904)3.14361054
50cell-cell junction maintenance (GO:0045217)3.11567814
51regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.10724440
52regulation of female receptivity (GO:0045924)3.06328505
53lateral sprouting from an epithelium (GO:0060601)3.04602624
54arginine catabolic process (GO:0006527)3.04590693
55sequestering of actin monomers (GO:0042989)3.02148359
56CDP-diacylglycerol metabolic process (GO:0046341)2.99738556
57neuronal action potential (GO:0019228)2.94124603
58glutathione biosynthetic process (GO:0006750)2.93228560
59intraciliary transport (GO:0042073)2.92976529
60negative regulation of cardiac muscle tissue growth (GO:0055022)2.91974221
61negative regulation of heart growth (GO:0061117)2.91974221
62negative regulation of transcription regulatory region DNA binding (GO:2000678)2.91750535
63vitamin catabolic process (GO:0009111)2.88502673
64fat-soluble vitamin catabolic process (GO:0042363)2.88502673
65female mating behavior (GO:0060180)2.86743923
66calcium ion import (GO:0070509)2.86355310
67negative regulation of telomerase activity (GO:0051974)2.85800609
68preassembly of GPI anchor in ER membrane (GO:0016254)2.85748946
69nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.83398819
70resolution of meiotic recombination intermediates (GO:0000712)2.81710082
71positive regulation of protein complex disassembly (GO:0043243)2.81257714
72cranial nerve morphogenesis (GO:0021602)2.80483690
73establishment of protein localization to mitochondrial membrane (GO:0090151)2.79538499
74axoneme assembly (GO:0035082)2.78690700
75cellular response to ammonium ion (GO:0071242)2.78516257
76retinal ganglion cell axon guidance (GO:0031290)2.74242440
77DNA methylation involved in gamete generation (GO:0043046)2.73089794
78behavioral response to nicotine (GO:0035095)2.71794079
79cellular response to electrical stimulus (GO:0071257)2.71549758
80negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.68992297
81urogenital system development (GO:0001655)2.68798758
82energy coupled proton transport, down electrochemical gradient (GO:0015985)2.68395519
83ATP synthesis coupled proton transport (GO:0015986)2.68395519
84nonribosomal peptide biosynthetic process (GO:0019184)2.67517512
85axonemal dynein complex assembly (GO:0070286)2.66084338
86negative regulation of heart rate (GO:0010459)2.61162079
87positive regulation of cardiac muscle cell differentiation (GO:2000727)2.60120835
88regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.60068072
89coenzyme catabolic process (GO:0009109)2.59770233
90smooth muscle tissue development (GO:0048745)2.57561112
91cardiovascular system development (GO:0072358)2.56088382
92regulation of calcium ion-dependent exocytosis (GO:0017158)2.55177288
93lens fiber cell differentiation (GO:0070306)2.54688633
94regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.54010447
95negative regulation of glycoprotein biosynthetic process (GO:0010561)2.53622230
96notochord development (GO:0030903)2.52909891
97protein import into peroxisome matrix (GO:0016558)2.52113561
98transmission of nerve impulse (GO:0019226)2.51547366
99cell junction maintenance (GO:0034331)2.51267644
100negative regulation of cytosolic calcium ion concentration (GO:0051481)10.5873401

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GLI1_17442700_ChIP-ChIP_MESCs_Mouse6.47210505
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.71711335
3RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.57546430
4VDR_22108803_ChIP-Seq_LS180_Human3.41979565
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.94727253
6ZNF274_21170338_ChIP-Seq_K562_Hela2.81021558
7TAF15_26573619_Chip-Seq_HEK293_Human2.75903296
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.65313158
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.49525088
10IKZF1_21737484_ChIP-ChIP_HCT116_Human2.25152911
11CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.15404925
12BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.01654110
13IGF1R_20145208_ChIP-Seq_DFB_Human1.96646348
14EZH2_22144423_ChIP-Seq_EOC_Human1.93700179
15POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.91986993
16TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.91986993
17EST1_17652178_ChIP-ChIP_JURKAT_Human1.91150095
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.90397792
19SALL1_21062744_ChIP-ChIP_HESCs_Human1.89599704
20FLI1_27457419_Chip-Seq_LIVER_Mouse1.88780143
21PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.85095394
22SMAD4_21799915_ChIP-Seq_A2780_Human1.75165610
23P300_19829295_ChIP-Seq_ESCs_Human1.71291946
24HTT_18923047_ChIP-ChIP_STHdh_Human1.68900962
25CTBP2_25329375_ChIP-Seq_LNCAP_Human1.66443699
26REST_21632747_ChIP-Seq_MESCs_Mouse1.64210669
27POU3F2_20337985_ChIP-ChIP_501MEL_Human1.60378848
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.59474748
29SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.59400904
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.58175882
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.57631766
32KLF5_20875108_ChIP-Seq_MESCs_Mouse1.56210739
33E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.55753438
34IRF1_19129219_ChIP-ChIP_H3396_Human1.52452391
35NANOG_19829295_ChIP-Seq_ESCs_Human1.51420395
36SOX2_19829295_ChIP-Seq_ESCs_Human1.51420395
37CBP_20019798_ChIP-Seq_JUKART_Human1.51200017
38IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.51200017
39GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.49029214
40AR_21572438_ChIP-Seq_LNCaP_Human1.44660914
41GABP_17652178_ChIP-ChIP_JURKAT_Human1.44559353
42STAT3_23295773_ChIP-Seq_U87_Human1.44257077
43EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.41920679
44ER_23166858_ChIP-Seq_MCF-7_Human1.40648839
45GBX2_23144817_ChIP-Seq_PC3_Human1.39646066
46FUS_26573619_Chip-Seq_HEK293_Human1.39358948
47MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.35861099
48TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31722343
49BCAT_22108803_ChIP-Seq_LS180_Human1.31108511
50TCF4_23295773_ChIP-Seq_U87_Human1.30203204
51NANOG_20526341_ChIP-Seq_ESCs_Human1.28002767
52CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26435553
53BMI1_23680149_ChIP-Seq_NPCS_Mouse1.24788807
54FOXA1_27270436_Chip-Seq_PROSTATE_Human1.20230405
55FOXA1_25329375_ChIP-Seq_VCAP_Human1.20230405
56HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.19555394
57SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17218902
58CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.17142485
59LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14896167
60PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.14559251
61ELF1_17652178_ChIP-ChIP_JURKAT_Human1.14198578
62RNF2_27304074_Chip-Seq_NSC_Mouse1.14178936
63EWS_26573619_Chip-Seq_HEK293_Human1.12702199
64TP53_22573176_ChIP-Seq_HFKS_Human1.12492676
65AR_25329375_ChIP-Seq_VCAP_Human1.11727268
66PCGF2_27294783_Chip-Seq_NPCs_Mouse1.11497280
67FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.11073662
68RXR_22108803_ChIP-Seq_LS180_Human1.11011789
69TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10888205
70PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.09639935
71JARID2_20064375_ChIP-Seq_MESCs_Mouse1.09138585
72GATA3_21878914_ChIP-Seq_MCF-7_Human1.08761307
73EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.08521621
74EZH2_27304074_Chip-Seq_ESCs_Mouse1.08286280
75FLI1_21867929_ChIP-Seq_TH2_Mouse1.07388348
76TAL1_26923725_Chip-Seq_HPCs_Mouse1.06621793
77PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.05178433
78TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05162401
79CDX2_19796622_ChIP-Seq_MESCs_Mouse1.03576909
80AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01684811
81PIAS1_25552417_ChIP-Seq_VCAP_Human1.01668845
82SOX2_16153702_ChIP-ChIP_HESCs_Human1.01658502
83NFE2_27457419_Chip-Seq_LIVER_Mouse1.01306244
84REST_18959480_ChIP-ChIP_MESCs_Mouse1.01186700
85EZH2_27294783_Chip-Seq_NPCs_Mouse0.99840894
86TCF4_22108803_ChIP-Seq_LS180_Human0.99176489
87SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.98065641
88RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.97160188
89EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95619667
90EED_16625203_ChIP-ChIP_MESCs_Mouse0.95589508
91UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94455387
92ETV2_25802403_ChIP-Seq_MESCs_Mouse0.92858994
93FOXA1_21572438_ChIP-Seq_LNCaP_Human0.91881183
94DROSHA_22980978_ChIP-Seq_HELA_Human0.91644156
95P53_22387025_ChIP-Seq_ESCs_Mouse0.90876945
96RUNX2_22187159_ChIP-Seq_PCA_Human0.90001015
97POU5F1_16153702_ChIP-ChIP_HESCs_Human0.88118519
98TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.87984152
99NANOG_18555785_Chip-Seq_ESCs_Mouse0.87930242
100TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.87641831

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue6.81888692
2MP0002837_dystrophic_cardiac_calcinosis5.01076025
3MP0002876_abnormal_thyroid_physiology3.86329872
4MP0005360_urolithiasis3.83057020
5MP0005167_abnormal_blood-brain_barrier2.99301877
6MP0002102_abnormal_ear_morphology2.91251989
7MP0008877_abnormal_DNA_methylation2.85313187
8MP0009780_abnormal_chondrocyte_physiolo2.82510367
9MP0006292_abnormal_olfactory_placode2.78835034
10MP0004147_increased_porphyrin_level2.50520810
11MP0003122_maternal_imprinting2.39177235
12MP0000537_abnormal_urethra_morphology2.37808194
13MP0005646_abnormal_pituitary_gland2.23508329
14MP0005551_abnormal_eye_electrophysiolog2.22342368
15MP0004742_abnormal_vestibular_system2.18209017
16MP0009278_abnormal_bone_marrow2.16556598
17MP0003121_genomic_imprinting2.13089278
18MP0001968_abnormal_touch/_nociception2.07414505
19MP0003787_abnormal_imprinting1.93872481
20MP0002733_abnormal_thermal_nociception1.90663833
21MP0005410_abnormal_fertilization1.86197638
22MP0002277_abnormal_respiratory_mucosa1.82835760
23MP0001545_abnormal_hematopoietic_system1.78679213
24MP0005397_hematopoietic_system_phenotyp1.78679213
25MP0009764_decreased_sensitivity_to1.66600267
26MP0000778_abnormal_nervous_system1.65898268
27MP0009046_muscle_twitch1.61936136
28MP0004145_abnormal_muscle_electrophysio1.61889888
29MP0008775_abnormal_heart_ventricle1.59606493
30MP0002272_abnormal_nervous_system1.53290833
31MP0004142_abnormal_muscle_tone1.50888677
32MP0005645_abnormal_hypothalamus_physiol1.48674686
33MP0003195_calcinosis1.48291120
34MP0003941_abnormal_skin_development1.47230847
35MP0001970_abnormal_pain_threshold1.44415783
36MP0004130_abnormal_muscle_cell1.43624547
37MP0004859_abnormal_synaptic_plasticity1.42271486
38MP0003880_abnormal_central_pattern1.36552155
39MP0006072_abnormal_retinal_apoptosis1.36191393
40MP0005499_abnormal_olfactory_system1.27397230
41MP0005394_taste/olfaction_phenotype1.27397230
42MP0006035_abnormal_mitochondrial_morpho1.27028437
43MP0009053_abnormal_anal_canal1.23611142
44MP0009745_abnormal_behavioral_response1.20432092
45MP0001485_abnormal_pinna_reflex1.20241213
46MP0005503_abnormal_tendon_morphology1.16257633
47MP0000681_abnormal_thyroid_gland1.15787382
48MP0003950_abnormal_plasma_membrane1.13323365
49MP0003633_abnormal_nervous_system1.10528684
50MP0004185_abnormal_adipocyte_glucose1.09239279
51MP0006054_spinal_hemorrhage1.08022760
52MP0008789_abnormal_olfactory_epithelium1.06964268
53MP0003938_abnormal_ear_development1.04352429
54MP0005253_abnormal_eye_physiology1.03550535
55MP0000049_abnormal_middle_ear1.02581986
56MP0005195_abnormal_posterior_eye1.02431783
57MP0001853_heart_inflammation1.00925979
58MP0000678_abnormal_parathyroid_gland1.00763535
59MP0008875_abnormal_xenobiotic_pharmacok1.00638452
60MP0002572_abnormal_emotion/affect_behav1.00133596
61MP0002229_neurodegeneration1.00095613
62MP0001188_hyperpigmentation0.98736739
63MP0009765_abnormal_xenobiotic_induced0.96977460
64MP0003635_abnormal_synaptic_transmissio0.92530921
65MP0001664_abnormal_digestion0.92178045
66MP0000955_abnormal_spinal_cord0.91017083
67MP0002557_abnormal_social/conspecific_i0.90592126
68MP0005310_abnormal_salivary_gland0.89469595
69MP0003567_abnormal_fetal_cardiomyocyte0.85186553
70MP0005389_reproductive_system_phenotype0.84437353
71MP0008872_abnormal_physiological_respon0.83694878
72MP0002693_abnormal_pancreas_physiology0.83624829
73MP0002067_abnormal_sensory_capabilities0.83123384
74MP0002095_abnormal_skin_pigmentation0.82988587
75MP0002752_abnormal_somatic_nervous0.82368501
76MP0002653_abnormal_ependyma_morphology0.80888709
77MP0001919_abnormal_reproductive_system0.77878964
78MP0002249_abnormal_larynx_morphology0.77014388
79MP0002063_abnormal_learning/memory/cond0.76217451
80MP0004043_abnormal_pH_regulation0.75555351
81MP0000569_abnormal_digit_pigmentation0.75372163
82MP0003638_abnormal_response/metabolism_0.74905161
83MP0001486_abnormal_startle_reflex0.71508936
84MP0003698_abnormal_male_reproductive0.71395067
85MP0004858_abnormal_nervous_system0.71391765
86MP0000647_abnormal_sebaceous_gland0.70329927
87MP0002882_abnormal_neuron_morphology0.68241508
88MP0003959_abnormal_lean_body0.67374231
89MP0001929_abnormal_gametogenesis0.65953113
90MP0003315_abnormal_perineum_morphology0.65480234
91MP0000230_abnormal_systemic_arterial0.64552739
92MP0006276_abnormal_autonomic_nervous0.63184675
93MP0002734_abnormal_mechanical_nocicepti0.62700278
94MP0003937_abnormal_limbs/digits/tail_de0.61262510
95MP0003045_fibrosis0.58988580
96MP0001944_abnormal_pancreas_morphology0.58963657
97MP0003631_nervous_system_phenotype0.57548928
98MP0003693_abnormal_embryo_hatching0.56858423
99MP0003690_abnormal_glial_cell0.56257987
100MP0005266_abnormal_metabolism0.55951506

Predicted human phenotypes

RankGene SetZ-score
1Thyroid-stimulating hormone excess (HP:0002925)9.24568486
2Volvulus (HP:0002580)7.09812559
3Agitation (HP:0000713)4.98897470
4Myokymia (HP:0002411)4.37454322
5Amblyopia (HP:0000646)3.92526249
6Abnormality of the nasal septum (HP:0000419)3.84162431
7Intestinal atresia (HP:0011100)3.74530457
8Genetic anticipation (HP:0003743)3.67188414
9Pancreatic islet-cell hyperplasia (HP:0004510)3.49989264
10Lissencephaly (HP:0001339)3.31340096
11Decreased central vision (HP:0007663)3.07995590
12Gaze-evoked nystagmus (HP:0000640)3.06328353
13Abnormality of the aortic arch (HP:0012303)3.03050306
14Tented upper lip vermilion (HP:0010804)2.94807900
15Poor speech (HP:0002465)2.92048176
16Congenital stationary night blindness (HP:0007642)2.87769586
17Pendular nystagmus (HP:0012043)2.85908701
18Impulsivity (HP:0100710)2.82526143
19Restlessness (HP:0000711)2.81989071
20Aplasia/Hypoplasia of the brainstem (HP:0007362)2.75287237
21Hypoplasia of the brainstem (HP:0002365)2.75287237
22Ketoacidosis (HP:0001993)2.72076436
23Broad-based gait (HP:0002136)2.70647605
24Malignant hyperthermia (HP:0002047)2.67429812
25Oligodontia (HP:0000677)2.62445754
26Poor head control (HP:0002421)2.57573314
27Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.54492637
28Methylmalonic aciduria (HP:0012120)2.51818481
29Anhidrosis (HP:0000970)2.49618743
30Microretrognathia (HP:0000308)2.49434832
31Medial flaring of the eyebrow (HP:0010747)2.45960043
32Tubular atrophy (HP:0000092)2.45818016
33Increased corneal curvature (HP:0100692)2.43609601
34Keratoconus (HP:0000563)2.43609601
35Decreased electroretinogram (ERG) amplitude (HP:0000654)2.42910221
36Chromosomal breakage induced by crosslinking agents (HP:0003221)2.42807781
37Urinary bladder sphincter dysfunction (HP:0002839)2.40429852
38Mesangial abnormality (HP:0001966)2.33401889
39Abnormality of the ileum (HP:0001549)2.26375921
40Tetany (HP:0001281)2.23231316
41Spastic tetraparesis (HP:0001285)2.21805219
42Hypomagnesemia (HP:0002917)2.20564612
43Median cleft lip (HP:0000161)2.19038515
44Acute necrotizing encephalopathy (HP:0006965)2.18433367
45Hypoproteinemia (HP:0003075)2.18293519
46Chromsome breakage (HP:0040012)2.15480086
47Absent/shortened dynein arms (HP:0200106)2.14885642
48Dynein arm defect of respiratory motile cilia (HP:0012255)2.14885642
49True hermaphroditism (HP:0010459)2.14870101
50Abnormality of the corticospinal tract (HP:0002492)2.12446644
51Optic nerve hypoplasia (HP:0000609)2.12260871
52Submucous cleft hard palate (HP:0000176)2.11153079
53Type II lissencephaly (HP:0007260)2.11136209
54Abnormality of alanine metabolism (HP:0010916)2.10612751
55Hyperalaninemia (HP:0003348)2.10612751
56Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.10612751
57Small hand (HP:0200055)2.09643417
58Congenital ichthyosiform erythroderma (HP:0007431)2.08002880
59Abnormal mitochondria in muscle tissue (HP:0008316)2.07282472
60Abnormality of midbrain morphology (HP:0002418)2.07165875
61Molar tooth sign on MRI (HP:0002419)2.07165875
62Large for gestational age (HP:0001520)2.06693184
63Abnormality of the proximal phalanges of the hand (HP:0009834)2.06428257
64Long nose (HP:0003189)2.04587877
65Esotropia (HP:0000565)2.04582469
66Chronic sinusitis (HP:0011109)2.02733398
67Pigmentary retinal degeneration (HP:0001146)2.01272311
68Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.98020878
69Myotonia (HP:0002486)1.96280334
70Abnormal respiratory motile cilium physiology (HP:0012261)1.94447487
71Duplicated collecting system (HP:0000081)1.94031376
72Focal motor seizures (HP:0011153)1.93121915
73Focal seizures (HP:0007359)1.92778995
74Broad alveolar ridges (HP:0000187)1.90110842
75Methylmalonic acidemia (HP:0002912)1.89642678
76Rhinitis (HP:0012384)1.87982286
77Hyperpituitarism (HP:0010514)1.86879817
78Abnormality of the renal collecting system (HP:0004742)1.86597928
79Abnormality of the pancreatic islet cells (HP:0006476)1.86516849
80Abnormality of endocrine pancreas physiology (HP:0012093)1.86516849
81Progressive cerebellar ataxia (HP:0002073)1.86292561
82Abnormality of the middle phalanges of the toes (HP:0010183)1.84242463
83Abnormal respiratory motile cilium morphology (HP:0005938)1.82195749
84Abnormal respiratory epithelium morphology (HP:0012253)1.82195749
85Progressive macrocephaly (HP:0004481)1.82080730
86Hyperglycinuria (HP:0003108)1.78984212
87Cerebellar dysplasia (HP:0007033)1.78772482
88Optic disc pallor (HP:0000543)1.78586864
89Short 1st metacarpal (HP:0010034)1.78097709
90Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.78097709
91Attenuation of retinal blood vessels (HP:0007843)1.77422566
92Acute encephalopathy (HP:0006846)1.75210002
93Pancreatic cysts (HP:0001737)1.74432048
94Cone-rod dystrophy (HP:0000548)1.74056382
95Abnormality of the labia minora (HP:0012880)1.73572899
96Abnormality of the lower motor neuron (HP:0002366)1.72955804
97Abnormal number of incisors (HP:0011064)1.72887696
98Chronic bronchitis (HP:0004469)1.72217932
99Gastrointestinal atresia (HP:0002589)1.71984361
100Pancreatic fibrosis (HP:0100732)1.71847922

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK166.72546494
2ADRBK25.88297223
3FRK4.36232572
4EPHB23.43578641
5TAOK32.58744357
6KSR12.53491207
7PINK12.50092706
8MAPK132.10357160
9ZAK2.08996887
10MAP4K11.95199005
11RIPK41.93997483
12TNK21.79364695
13MAP4K21.74257091
14IRAK11.72197999
15MARK11.53455162
16NUAK11.47621613
17MAP2K71.46203832
18DYRK31.45571387
19GRK11.45058502
20PLK21.39047858
21MAP3K111.38352184
22BMPR1B1.34605991
23ADRBK11.32422089
24STK241.31892532
25PRKCG1.24322648
26RPS6KA41.24241926
27WNK31.17542273
28MAP3K91.13056850
29PRKCE1.01538078
30PNCK1.01324359
31IRAK31.00089719
32ERBB20.94132744
33TYRO30.86338883
34CSNK1G20.83715954
35CAMKK20.82375127
36CSNK1G30.80911171
37ERN10.80508969
38PAK30.80491041
39TRIM280.78849329
40NTRK20.77243083
41TGFBR10.75177975
42WNK40.72620196
43DYRK1A0.72542569
44INSRR0.71378696
45CSNK1G10.68119014
46CAMK2A0.67107481
47CAMKK10.65061561
48MKNK10.63936409
49CASK0.63441381
50TAF10.63171047
51TIE10.62873239
52CSNK1A1L0.62516924
53EPHA40.62321869
54FYN0.61716896
55PKN10.60237252
56PRKCI0.59613058
57BCR0.59480795
58VRK10.58014269
59KIT0.55818067
60FES0.55534335
61MAPKAPK50.54823344
62CAMK10.54622416
63SGK10.54504704
64CSNK1A10.54168019
65MAP3K40.51538545
66IRAK20.50857115
67PHKG20.49873141
68PHKG10.49873141
69TXK0.49602451
70PRKACA0.47131189
71ERBB30.46097202
72CSF1R0.43940947
73STK30.43457598
74ATM0.43082976
75MINK10.41513740
76TEC0.40314057
77MAP2K40.38748215
78PRKCA0.38234761
79DYRK20.37799996
80CSNK1E0.37571771
81ACVR1B0.37396410
82MAP2K60.35586968
83PIK3CA0.35461683
84GRK70.35061481
85CAMK1G0.34869027
86MAPK30.34607980
87MAPK100.32530730
88CSNK2A20.32431190
89IRAK40.32272963
90RPS6KA30.31442716
91ATR0.30847515
92PLK30.30004360
93STK110.29470662
94NTRK30.29323927
95RPS6KA50.29271257
96PRKG10.28319562
97PRKACG0.28059360
98OBSCN0.27924356
99DAPK20.27490503
100GRK50.27469433

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041223.90158985
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.48399123
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.99236462
4Nicotine addiction_Homo sapiens_hsa050332.81978509
5Cyanoamino acid metabolism_Homo sapiens_hsa004602.79496015
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.74529718
7Dorso-ventral axis formation_Homo sapiens_hsa043202.30528995
8Oxidative phosphorylation_Homo sapiens_hsa001902.29081127
9Phototransduction_Homo sapiens_hsa047442.24493127
10Parkinsons disease_Homo sapiens_hsa050122.18502298
11Morphine addiction_Homo sapiens_hsa050322.12840798
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.07723474
13Insulin secretion_Homo sapiens_hsa049111.96719742
14Nitrogen metabolism_Homo sapiens_hsa009101.88280250
15Olfactory transduction_Homo sapiens_hsa047401.80226678
16Steroid hormone biosynthesis_Homo sapiens_hsa001401.72060208
17Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.71072564
18Cardiac muscle contraction_Homo sapiens_hsa042601.70307043
19Butanoate metabolism_Homo sapiens_hsa006501.66643868
20Mineral absorption_Homo sapiens_hsa049781.60641961
21Taste transduction_Homo sapiens_hsa047421.57755126
22Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.55699178
23Sphingolipid metabolism_Homo sapiens_hsa006001.51361758
24Huntingtons disease_Homo sapiens_hsa050161.50276349
25Asthma_Homo sapiens_hsa053101.49568515
26Alzheimers disease_Homo sapiens_hsa050101.45439656
27Ovarian steroidogenesis_Homo sapiens_hsa049131.44360707
28Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.40617230
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.37653123
30Intestinal immune network for IgA production_Homo sapiens_hsa046721.37611803
31Basal transcription factors_Homo sapiens_hsa030221.34835659
32Glutamatergic synapse_Homo sapiens_hsa047241.28510409
33ABC transporters_Homo sapiens_hsa020101.23474709
34Linoleic acid metabolism_Homo sapiens_hsa005911.23161716
35GABAergic synapse_Homo sapiens_hsa047271.13251316
36Type II diabetes mellitus_Homo sapiens_hsa049301.08493419
37RNA degradation_Homo sapiens_hsa030181.08275772
38Chemical carcinogenesis_Homo sapiens_hsa052041.02809702
39Peroxisome_Homo sapiens_hsa041460.98104942
40Glycerolipid metabolism_Homo sapiens_hsa005610.96691599
41Vitamin B6 metabolism_Homo sapiens_hsa007500.96457953
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.95915446
43Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.94367016
44Fanconi anemia pathway_Homo sapiens_hsa034600.93463278
45Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.93408221
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.93048630
47Sulfur metabolism_Homo sapiens_hsa009200.91626633
48Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.90731744
49Tryptophan metabolism_Homo sapiens_hsa003800.89379688
50Graft-versus-host disease_Homo sapiens_hsa053320.87374969
51Proteasome_Homo sapiens_hsa030500.84902900
52Retinol metabolism_Homo sapiens_hsa008300.83852249
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.83593185
54alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.83476818
55Caffeine metabolism_Homo sapiens_hsa002320.80281515
56Type I diabetes mellitus_Homo sapiens_hsa049400.78447423
57Autoimmune thyroid disease_Homo sapiens_hsa053200.78225426
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.77250879
59Allograft rejection_Homo sapiens_hsa053300.77097404
60Homologous recombination_Homo sapiens_hsa034400.76374211
61Salivary secretion_Homo sapiens_hsa049700.76318467
62Systemic lupus erythematosus_Homo sapiens_hsa053220.76096930
63Circadian entrainment_Homo sapiens_hsa047130.75798528
64Ether lipid metabolism_Homo sapiens_hsa005650.75656826
65Spliceosome_Homo sapiens_hsa030400.73930580
66Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73871803
67Primary bile acid biosynthesis_Homo sapiens_hsa001200.70522345
68Glycerophospholipid metabolism_Homo sapiens_hsa005640.67688365
69Calcium signaling pathway_Homo sapiens_hsa040200.66905240
70Arachidonic acid metabolism_Homo sapiens_hsa005900.65744520
71Serotonergic synapse_Homo sapiens_hsa047260.57758389
72Complement and coagulation cascades_Homo sapiens_hsa046100.56352147
73Metabolic pathways_Homo sapiens_hsa011000.53946656
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.53626304
75Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.53432334
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.53220592
77Drug metabolism - other enzymes_Homo sapiens_hsa009830.52927310
78Alcoholism_Homo sapiens_hsa050340.51118607
79cAMP signaling pathway_Homo sapiens_hsa040240.50873684
80Glutathione metabolism_Homo sapiens_hsa004800.50813916
81Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49502519
82Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.49199807
83Starch and sucrose metabolism_Homo sapiens_hsa005000.49061517
84Cocaine addiction_Homo sapiens_hsa050300.48202187
85Purine metabolism_Homo sapiens_hsa002300.46630409
86Ribosome_Homo sapiens_hsa030100.44676933
87Propanoate metabolism_Homo sapiens_hsa006400.44040960
88Maturity onset diabetes of the young_Homo sapiens_hsa049500.43722245
89Rheumatoid arthritis_Homo sapiens_hsa053230.43154527
90Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41500667
91Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40499491
92Staphylococcus aureus infection_Homo sapiens_hsa051500.40224583
93Amphetamine addiction_Homo sapiens_hsa050310.37141800
94Bile secretion_Homo sapiens_hsa049760.34602585
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.31414725
96Steroid biosynthesis_Homo sapiens_hsa001000.30236310
97Antigen processing and presentation_Homo sapiens_hsa046120.29092046
98Protein export_Homo sapiens_hsa030600.26565683
99Fat digestion and absorption_Homo sapiens_hsa049750.25416136
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.25218070

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