MINK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-related kinases within the GCK family. Studies of the mouse homolog indicate an up-regulation of expression in the course of postnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.91012240
2locomotory exploration behavior (GO:0035641)5.79214851
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.30880494
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.19224178
5regulation of synapse structural plasticity (GO:0051823)4.81442298
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.72472392
7synaptic vesicle docking involved in exocytosis (GO:0016081)4.53441141
8vocalization behavior (GO:0071625)4.48464902
9regulation of neuronal synaptic plasticity (GO:0048168)4.27720332
10sodium ion export (GO:0071436)4.20773411
11glutamate secretion (GO:0014047)4.20431969
12synaptic vesicle exocytosis (GO:0016079)4.18141450
13regulation of long-term neuronal synaptic plasticity (GO:0048169)4.17542500
14negative regulation of erythrocyte differentiation (GO:0045647)4.01786133
15regulation of synaptic vesicle exocytosis (GO:2000300)3.98552520
16* regulation of glutamate receptor signaling pathway (GO:1900449)3.92004834
17membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.86238043
18exploration behavior (GO:0035640)3.85590590
19positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.84810519
20neurotransmitter secretion (GO:0007269)3.83724748
21neuromuscular process controlling balance (GO:0050885)3.82681761
22layer formation in cerebral cortex (GO:0021819)3.82235151
23* regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.81129879
24cellular potassium ion homeostasis (GO:0030007)3.78674221
25prepulse inhibition (GO:0060134)3.76643341
26ionotropic glutamate receptor signaling pathway (GO:0035235)3.73155342
27activation of protein kinase A activity (GO:0034199)3.69893369
28dendritic spine morphogenesis (GO:0060997)3.67774298
29neurotransmitter-gated ion channel clustering (GO:0072578)3.63978551
30regulation of ARF protein signal transduction (GO:0032012)3.62210198
31regulation of synaptic vesicle transport (GO:1902803)3.58342461
32protein localization to endosome (GO:0036010)3.54233970
33neuronal action potential propagation (GO:0019227)3.50788866
34gamma-aminobutyric acid transport (GO:0015812)3.49588919
35mannose metabolic process (GO:0006013)3.47388390
36regulation of dendritic spine morphogenesis (GO:0061001)3.47238209
37long-term memory (GO:0007616)3.46091473
38glycine transport (GO:0015816)3.39973667
39positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.39326666
40cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.35631304
41G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.34549256
42protein localization to synapse (GO:0035418)3.32714226
43cytoskeletal anchoring at plasma membrane (GO:0007016)3.32425353
44regulation of excitatory postsynaptic membrane potential (GO:0060079)3.30451039
45proline transport (GO:0015824)3.29166972
46desmosome organization (GO:0002934)3.29106272
47positive regulation of membrane potential (GO:0045838)3.27925114
48auditory behavior (GO:0031223)3.27638626
49synaptic transmission, glutamatergic (GO:0035249)3.26565579
50regulation of synaptic plasticity (GO:0048167)3.25451905
51adenosine receptor signaling pathway (GO:0001973)3.19888290
52hemidesmosome assembly (GO:0031581)3.15227903
53cell communication by electrical coupling (GO:0010644)3.11040365
54regulation of early endosome to late endosome transport (GO:2000641)3.09092855
55regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.04456230
56neuron-neuron synaptic transmission (GO:0007270)3.04424355
57cell-substrate junction assembly (GO:0007044)3.04421058
58regulation of postsynaptic membrane potential (GO:0060078)3.03467398
59neuronal ion channel clustering (GO:0045161)3.02612704
60neuromuscular process controlling posture (GO:0050884)3.02206803
61potassium ion import (GO:0010107)3.02119179
62response to auditory stimulus (GO:0010996)3.01908570
63negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.01873407
64positive regulation of synaptic transmission, GABAergic (GO:0032230)2.99855764
65adherens junction assembly (GO:0034333)2.99676655
66glutamate receptor signaling pathway (GO:0007215)2.98579587
67L-amino acid import (GO:0043092)2.98454538
68focal adhesion assembly (GO:0048041)2.92064738
69cell-substrate adherens junction assembly (GO:0007045)2.92064738
70regulation of ARF GTPase activity (GO:0032312)2.91023230
71neurotransmitter transport (GO:0006836)2.89664609
72cellular sodium ion homeostasis (GO:0006883)2.89384478
73response to laminar fluid shear stress (GO:0034616)2.89107090
74activation of Rac GTPase activity (GO:0032863)2.87589090
75positive regulation of neurotransmitter transport (GO:0051590)2.86899178
76regulation of clathrin-mediated endocytosis (GO:2000369)2.85882524
77regulation of neurotransmitter levels (GO:0001505)2.85485723
78negative regulation of cytosolic calcium ion concentration (GO:0051481)2.83643362
79vesicle transport along microtubule (GO:0047496)2.83351067
80regulation of Rap GTPase activity (GO:0032317)2.81833961
81dopamine receptor signaling pathway (GO:0007212)2.81323224
82regulation of synaptic transmission, glutamatergic (GO:0051966)2.80958306
83positive regulation of Cdc42 GTPase activity (GO:0043089)2.80602877
84regulation of extracellular matrix disassembly (GO:0010715)2.79395899
85semaphorin-plexin signaling pathway (GO:0071526)2.79000505
86regulation of female receptivity (GO:0045924)2.78456813
87membrane depolarization during action potential (GO:0086010)2.76682365
88positive regulation of synapse maturation (GO:0090129)2.76524219
89positive regulation of Rap GTPase activity (GO:0032854)2.75935714
90long-term synaptic potentiation (GO:0060291)2.75807761
91cerebellar Purkinje cell differentiation (GO:0021702)2.74876360
92transmission of nerve impulse (GO:0019226)2.74853110
93neuromuscular process (GO:0050905)2.74852230
94signal complex assembly (GO:0007172)2.74599753
95dendritic spine organization (GO:0097061)2.74380880
96regulation of dendritic spine development (GO:0060998)2.73501002
97positive regulation of receptor recycling (GO:0001921)2.71508847
98cell communication involved in cardiac conduction (GO:0086065)2.71023472
99barbed-end actin filament capping (GO:0051016)2.70937160
100striatum development (GO:0021756)2.70735652
101adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.70244453
102synaptic vesicle endocytosis (GO:0048488)2.69411605
103stress fiber assembly (GO:0043149)2.68632344
104epithelial cell differentiation involved in prostate gland development (GO:0060742)2.68594276
105positive regulation of neurotransmitter secretion (GO:0001956)2.67768949
106regulation of cholesterol homeostasis (GO:2000188)2.67761908
107regulation of voltage-gated calcium channel activity (GO:1901385)2.67031426
108establishment of nucleus localization (GO:0040023)2.66533752
109membrane depolarization (GO:0051899)2.65576112
110mating behavior (GO:0007617)2.64564008
111cAMP biosynthetic process (GO:0006171)2.63606732
112negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.63522319
113amino acid import (GO:0043090)2.62625784
114negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.62445422
115nerve growth factor signaling pathway (GO:0038180)2.61576779
116membrane hyperpolarization (GO:0060081)2.60776500
117regulation of neurotransmitter secretion (GO:0046928)2.59219711
118regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.59124335
119cell-cell junction maintenance (GO:0045217)2.59006500
120alanine transport (GO:0032328)2.58363442
121peptidyl-tyrosine autophosphorylation (GO:0038083)2.57921103
122positive regulation of synaptic transmission (GO:0050806)2.57529643
123visual learning (GO:0008542)2.57434887
124chemosensory behavior (GO:0007635)2.56791337
125positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.56101966
126cerebellar granule cell differentiation (GO:0021707)2.55688834
127response to muramyl dipeptide (GO:0032495)2.53909600
128positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.47411982
129negative regulation of cell killing (GO:0031342)2.46579216
130negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.46579216
131antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.44172467
132COPI coating of Golgi vesicle (GO:0048205)2.43943697
133Golgi transport vesicle coating (GO:0048200)2.43943697
134regulation of T-helper 2 cell differentiation (GO:0045628)2.43318710
135cortical actin cytoskeleton organization (GO:0030866)2.39508280
136surfactant homeostasis (GO:0043129)2.39179361
137positive regulation of protein dephosphorylation (GO:0035307)2.38262292
138positive regulation of cellular amide metabolic process (GO:0034250)2.37840839
139retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.37081518
140embryonic process involved in female pregnancy (GO:0060136)2.36518712
141activation of JUN kinase activity (GO:0007257)2.34581614
142detection of bacterium (GO:0016045)2.33503327
143regulation of water loss via skin (GO:0033561)2.30603620
144antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.29093661
145positive regulation of extracellular matrix organization (GO:1903055)2.28858235
146detection of other organism (GO:0098543)2.28531883
147antigen processing and presentation of endogenous antigen (GO:0019883)2.28422977
148protein targeting to plasma membrane (GO:0072661)2.28139145
149regulation of extracellular matrix organization (GO:1903053)2.26775349
150negative regulation of myotube differentiation (GO:0010832)2.25409395
151activation of MAPKKK activity (GO:0000185)2.24636092
152cell volume homeostasis (GO:0006884)2.23322943
153regulation of leukocyte degranulation (GO:0043300)2.22358576
154modulation by symbiont of host cellular process (GO:0044068)2.21705473
155apoptotic process involved in morphogenesis (GO:0060561)2.21584901
156endothelial cell chemotaxis (GO:0035767)2.20921594
157myelin maintenance (GO:0043217)2.17064611
158protein retention in ER lumen (GO:0006621)2.16013632
159skin morphogenesis (GO:0043589)2.15242137
160negative regulation of fatty acid transport (GO:2000192)2.13499551
161positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.11491980
162regulation of glucose import in response to insulin stimulus (GO:2001273)2.10974843
163cortical cytoskeleton organization (GO:0030865)2.10540130
164positive thymic T cell selection (GO:0045059)2.09881664
165modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.09854960
166positive regulation by organism of defense response of other organism involved in symbiotic interact2.09854960
167modulation by symbiont of host immune response (GO:0052553)2.09854960
168positive regulation by symbiont of host defense response (GO:0052509)2.09854960
169modulation by symbiont of host defense response (GO:0052031)2.09854960
170modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.09854960
171regulation of lipid kinase activity (GO:0043550)2.09692397
172negative regulation of toll-like receptor signaling pathway (GO:0034122)2.09083300
173establishment of skin barrier (GO:0061436)2.08712784
174negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.08666603
175pinocytosis (GO:0006907)2.08600237
176maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.07840002
177planar cell polarity pathway involved in neural tube closure (GO:0090179)2.07801038
178regulation of myeloid leukocyte mediated immunity (GO:0002886)2.07649228
179hypotonic response (GO:0006971)2.07630284
180regulation of NFAT protein import into nucleus (GO:0051532)2.07466528
181regulation of amyloid precursor protein catabolic process (GO:1902991)2.07430460
182epithelial cell-cell adhesion (GO:0090136)2.06196771

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.05887928
2EZH2_22144423_ChIP-Seq_EOC_Human3.65128215
3RARB_27405468_Chip-Seq_BRAIN_Mouse3.07762859
4DROSHA_22980978_ChIP-Seq_HELA_Human2.83938552
5EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.73127569
6MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.66237072
7RARG_19884340_ChIP-ChIP_MEFs_Mouse2.46519830
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.40130516
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.33848521
10ELK3_25401928_ChIP-Seq_HUVEC_Human2.32147977
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.24650510
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.24650510
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.20746711
14JARID2_20064375_ChIP-Seq_MESCs_Mouse2.18792127
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.18300585
16VDR_21846776_ChIP-Seq_THP-1_Human2.12977451
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.09645242
18REST_21632747_ChIP-Seq_MESCs_Mouse2.05717712
19MYC_22102868_ChIP-Seq_BL_Human2.05712871
20IKZF1_21737484_ChIP-ChIP_HCT116_Human2.04993267
21NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.04792316
22SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.94795728
23SUZ12_27294783_Chip-Seq_ESCs_Mouse1.92065555
24SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.90641968
25KDM2B_26808549_Chip-Seq_K562_Human1.90337055
26ERG_21242973_ChIP-ChIP_JURKAT_Human1.86014521
27TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.85224642
28EZH2_27294783_Chip-Seq_ESCs_Mouse1.82402367
29REST_18959480_ChIP-ChIP_MESCs_Mouse1.80656226
30KDM2B_26808549_Chip-Seq_SUP-B15_Human1.76595100
31DNAJC2_21179169_ChIP-ChIP_NT2_Human1.76086244
32SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.75536141
33RNF2_27304074_Chip-Seq_ESCs_Mouse1.74909169
34THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.72804300
35ZFP281_18757296_ChIP-ChIP_E14_Mouse1.65103450
36* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.64070549
37GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.58175755
38CLOCK_20551151_ChIP-Seq_293T_Human1.56838709
39EZH2_27304074_Chip-Seq_ESCs_Mouse1.56622107
40* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.56020478
41UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.52603119
42KDM2B_26808549_Chip-Seq_DND41_Human1.51297816
43TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51156826
44KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.50693850
45LXR_22292898_ChIP-Seq_THP-1_Human1.50242701
46GBX2_23144817_ChIP-Seq_PC3_Human1.46307803
47EGR1_19374776_ChIP-ChIP_THP-1_Human1.46193138
48VDR_24763502_ChIP-Seq_THP-1_Human1.45360652
49RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.45045165
50* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.42989440
51ZFP281_27345836_Chip-Seq_ESCs_Mouse1.42818517
52ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.42460744
53AR_21572438_ChIP-Seq_LNCaP_Human1.41560987
54KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.40774674
55CTCF_27219007_Chip-Seq_ERYTHROID_Human1.39131859
56VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.38644917
57ESR2_21235772_ChIP-Seq_MCF-7_Human1.37493246
58P68_20966046_ChIP-Seq_HELA_Human1.35573925
59EED_16625203_ChIP-ChIP_MESCs_Mouse1.34473906
60TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.33237394
61SA1_27219007_Chip-Seq_ERYTHROID_Human1.33153555
62E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.32922073
63GATA1_19941827_ChIP-Seq_MEL_Mouse1.31529550
64TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.30912843
65SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30188876
66PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.29833165
67KDM2B_26808549_Chip-Seq_JURKAT_Human1.28333446
68SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.28202520
69MAF_26560356_Chip-Seq_TH1_Human1.27802422
70NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.26575051
71RUNX1_22412390_ChIP-Seq_EML_Mouse1.25823528
72DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.24800325
73SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.24180673
74RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.23267424
75CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.23045304
76ESR1_21235772_ChIP-Seq_MCF-7_Human1.22991964
77* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.22780100
78* RUNX1_27514584_Chip-Seq_MCF-7_Human1.22646353
79RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.21664171
80BRD4_27068464_Chip-Seq_AML-cells_Mouse1.21548485
81SRY_22984422_ChIP-ChIP_TESTIS_Rat1.18636532
82NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.17658396
83RING1B_27294783_Chip-Seq_ESCs_Mouse1.16704939
84P63_26484246_Chip-Seq_KERATINOCYTES_Human1.15350128
85ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14780713
86NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.14712147
87TET1_21451524_ChIP-Seq_MESCs_Mouse1.14177170
88CTCF_27219007_Chip-Seq_Bcells_Human1.13569497
89MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.12742327
90MYB_21317192_ChIP-Seq_ERMYB_Mouse1.11125110
91KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.10901104
92AR_19668381_ChIP-Seq_PC3_Human1.10633063
93CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.09633596
94SOX9_24532713_ChIP-Seq_HFSC_Mouse1.09586409
95SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09447526
96UTX_26944678_Chip-Seq_JUKART_Human1.09233638
97ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.08574826
98KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.07860495
99SOX2_27498859_Chip-Seq_STOMACH_Mouse1.07363641
100ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.07050711
101TP63_22573176_ChIP-Seq_HFKS_Human1.05986195
102NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.05717829
103KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.05518773
104* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.05304567
105ESR1_20079471_ChIP-ChIP_T-47D_Human1.03527007
106* SMC4_20622854_ChIP-Seq_HELA_Human1.03492574
107STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.02948618
108* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.02631060
109* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.02629967
110MAF_26560356_Chip-Seq_TH2_Human1.02040016
111CREB1_26743006_Chip-Seq_LNCaP_Human1.01853943
112* TET1_21490601_ChIP-Seq_MESCs_Mouse1.01629228
113NCOR1_26117541_ChIP-Seq_K562_Human1.01627603
114TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.01174524
115AHR_22903824_ChIP-Seq_MCF-7_Human1.00692157
116PPARA_22158963_ChIP-Seq_LIVER_Mouse1.00499626
117RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.00424295
118ATF3_27146783_Chip-Seq_COLON_Human1.00118911
119* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99587486
120SOX2_21211035_ChIP-Seq_LN229_Gbm0.99317358
121GATA1_22383799_ChIP-Seq_G1ME_Mouse0.99113845
122GATA2_21666600_ChIP-Seq_HMVEC_Human0.98919813
123FOXA2_19822575_ChIP-Seq_HepG2_Human0.98434386
124BCOR_27268052_Chip-Seq_Bcells_Human0.98319644
125TBX20_22080862_ChIP-Seq_HEART_Mouse0.98199775
126TBX20_22328084_ChIP-Seq_HEART_Mouse0.98199775
127TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98113558
128SMAD3_21741376_ChIP-Seq_HESCs_Human0.97866290
129RXR_22158963_ChIP-Seq_LIVER_Mouse0.97736929
130BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97675494
131KLF4_19829295_ChIP-Seq_ESCs_Human0.97614030
132RXR_22108803_ChIP-Seq_LS180_Human0.97178372
133TCF7_22412390_ChIP-Seq_EML_Mouse0.96827506
134RING1B_27294783_Chip-Seq_NPCs_Mouse0.96732915
135SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.96377761
136GATA1_19941826_ChIP-Seq_K562_Human0.96328200
137NR3C1_23031785_ChIP-Seq_PC12_Mouse0.95633497
138PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93366664
139SMAD4_21741376_ChIP-Seq_HESCs_Human0.90721080
140RACK7_27058665_Chip-Seq_MCF-7_Human0.90502699
141ZNF263_19887448_ChIP-Seq_K562_Human0.89305282
142RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.89066385
143ARNT_22903824_ChIP-Seq_MCF-7_Human0.87418976
144P300_27058665_Chip-Seq_ZR-75-30cells_Human0.86422278
145* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.84401054
146CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.83767479
147SMAD4_21799915_ChIP-Seq_A2780_Human0.83276227
148* OCT4_19829295_ChIP-Seq_ESCs_Human0.82099472
149SPI1_23127762_ChIP-Seq_K562_Human0.82090114
150SMAD_19615063_ChIP-ChIP_OVARY_Human0.81071004
151SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.80985989
152SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.80725539
153EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.80087872
154P53_22127205_ChIP-Seq_FIBROBLAST_Human0.80082172
155STAT6_21828071_ChIP-Seq_BEAS2B_Human0.79899573
156TP53_16413492_ChIP-PET_HCT116_Human0.79732821
157ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.78762614

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.42679269
2MP0002822_catalepsy5.27984195
3MP0003635_abnormal_synaptic_transmissio3.99102823
4MP0004270_analgesia3.30681744
5MP0009745_abnormal_behavioral_response3.19472987
6MP0002063_abnormal_learning/memory/cond3.16323909
7MP0003880_abnormal_central_pattern3.15970772
8MP0002064_seizures2.91559386
9MP0003566_abnormal_cell_adhesion2.67302059
10MP0005409_darkened_coat_color2.66013370
11MP0009046_muscle_twitch2.55675942
12MP0008260_abnormal_autophagy2.41009796
13MP0002909_abnormal_adrenal_gland2.37182278
14MP0002572_abnormal_emotion/affect_behav2.36892799
15MP0001849_ear_inflammation2.29577112
16MP0001486_abnormal_startle_reflex2.28224398
17MP0003436_decreased_susceptibility_to2.27012252
18MP0002796_impaired_skin_barrier2.24846589
19MP0009780_abnormal_chondrocyte_physiolo2.21423984
20MP0003453_abnormal_keratinocyte_physiol2.20030441
21MP0002272_abnormal_nervous_system2.19386954
22MP0001968_abnormal_touch/_nociception2.17853654
23MP0004858_abnormal_nervous_system2.17365334
24MP0003329_amyloid_beta_deposits2.16762113
25MP0004947_skin_inflammation2.08532688
26MP0005076_abnormal_cell_differentiation2.08240648
27MP0008569_lethality_at_weaning2.07528268
28MP0005423_abnormal_somatic_nervous2.07347343
29MP0001501_abnormal_sleep_pattern2.06545614
30MP0008961_abnormal_basal_metabolism2.00996050
31MP0005451_abnormal_body_composition1.97278098
32MP0003075_altered_response_to1.97030649
33MP0003091_abnormal_cell_migration1.93340828
34MP0002734_abnormal_mechanical_nocicepti1.90969136
35MP0000579_abnormal_nail_morphology1.79555105
36MP0010234_abnormal_vibrissa_follicle1.78940019
37MP0004885_abnormal_endolymph1.78311469
38MP0001958_emphysema1.73521795
39MP0004811_abnormal_neuron_physiology1.72104762
40MP0008438_abnormal_cutaneous_collagen1.67640848
41MP0005167_abnormal_blood-brain_barrier1.67512259
42MP0003879_abnormal_hair_cell1.62487019
43MP0003633_abnormal_nervous_system1.61345959
44MP0002733_abnormal_thermal_nociception1.59843023
45MP0003690_abnormal_glial_cell1.58300450
46MP0001440_abnormal_grooming_behavior1.55871324
47MP0001970_abnormal_pain_threshold1.54124229
48MP0004510_myositis1.51644964
49MP0000569_abnormal_digit_pigmentation1.48025738
50MP0002877_abnormal_melanocyte_morpholog1.44984169
51MP0009278_abnormal_bone_marrow1.44769459
52MP0005023_abnormal_wound_healing1.42844411
53MP0002736_abnormal_nociception_after1.42526844
54MP0005275_abnormal_skin_tensile1.41944201
55MP0003283_abnormal_digestive_organ1.41053546
56MP0000678_abnormal_parathyroid_gland1.40786955
57MP0008874_decreased_physiological_sensi1.39979215
58MP0005386_behavior/neurological_phenoty1.39204536
59MP0004924_abnormal_behavior1.39204536
60MP0000604_amyloidosis1.38893229
61MP0000858_altered_metastatic_potential1.34797083
62MP0004264_abnormal_extraembryonic_tissu1.34638510
63MP0002998_abnormal_bone_remodeling1.34611345
64MP0002735_abnormal_chemical_nociception1.34091003
65MP0002060_abnormal_skin_morphology1.33858417
66MP0002067_abnormal_sensory_capabilities1.31660992
67MP0003279_aneurysm1.30511740
68MP0005501_abnormal_skin_physiology1.29856263
69MP0002557_abnormal_social/conspecific_i1.29059901
70MP0000751_myopathy1.27904779
71MP0001851_eye_inflammation1.26832330
72MP0000955_abnormal_spinal_cord1.25881654
73MP0003172_abnormal_lysosome_physiology1.25025302
74MP0005464_abnormal_platelet_physiology1.23444747
75MP0003631_nervous_system_phenotype1.23043685
76MP0005666_abnormal_adipose_tissue1.22063967
77MP0002066_abnormal_motor_capabilities/c1.21070548
78MP0001533_abnormal_skeleton_physiology1.18919630
79MP0004381_abnormal_hair_follicle1.18133046
80MP0004130_abnormal_muscle_cell1.17978526
81MP0005646_abnormal_pituitary_gland1.17474367
82MP0008872_abnormal_physiological_respon1.16498187
83MP0003183_abnormal_peptide_metabolism1.14366908
84MP0000685_abnormal_immune_system1.09681296
85MP0000920_abnormal_myelination1.08533682
86MP0003705_abnormal_hypodermis_morpholog1.08029045
87MP0002419_abnormal_innate_immunity1.07489187
88MP0001216_abnormal_epidermal_layer1.06190492
89MP0005535_abnormal_body_temperature1.05644397
90MP0002184_abnormal_innervation1.04974452
91MP0002882_abnormal_neuron_morphology1.04188657
92MP0003300_gastrointestinal_ulcer1.03707647
93MP0010155_abnormal_intestine_physiology1.03192604
94MP0005025_abnormal_response_to1.01979308
95MP0003763_abnormal_thymus_physiology1.00522933
96MP0001177_atelectasis0.99827669
97MP0000467_abnormal_esophagus_morphology0.98139100
98MP0003045_fibrosis0.97102715
99MP0003303_peritoneal_inflammation0.96059706
100MP0005387_immune_system_phenotype0.94313010
101MP0001790_abnormal_immune_system0.94313010
102MP0003828_pulmonary_edema0.93669740
103MP0002069_abnormal_eating/drinking_beha0.93427190
104MP0005166_decreased_susceptibility_to0.92820805
105MP0005000_abnormal_immune_tolerance0.92473245
106MP0004782_abnormal_surfactant_physiolog0.90560683
107MP0001502_abnormal_circadian_rhythm0.90508446
108MP0010352_gastrointestinal_tract_polyps0.89019871
109MP0000778_abnormal_nervous_system0.88917124
110MP0000013_abnormal_adipose_tissue0.88599832
111MP0005257_abnormal_intraocular_pressure0.87936978
112MP0002090_abnormal_vision0.87410389
113MP0003866_abnormal_defecation0.87260443
114MP0002896_abnormal_bone_mineralization0.86604264
115MP0000566_synostosis0.86222082
116MP0004085_abnormal_heartbeat0.85448730
117MP0003634_abnormal_glial_cell0.83826361
118MP0009931_abnormal_skin_appearance0.82817536
119MP0005621_abnormal_cell_physiology0.82790642
120MP0000767_abnormal_smooth_muscle0.82191928
121MP0002249_abnormal_larynx_morphology0.82068285
122MP0003632_abnormal_nervous_system0.81715694
123MP0002254_reproductive_system_inflammat0.81564619
124MP0009333_abnormal_splenocyte_physiolog0.80141962
125MP0004272_abnormal_basement_membrane0.79016026
126MP0002152_abnormal_brain_morphology0.78602373
127MP0000747_muscle_weakness0.77820699
128MP0003724_increased_susceptibility_to0.76927238
129MP0004043_abnormal_pH_regulation0.76266342
130MP0003787_abnormal_imprinting0.75444172
131MP0002229_neurodegeneration0.75042805
132MP0002098_abnormal_vibrissa_morphology0.73378012
133MP0005623_abnormal_meninges_morphology0.73322977
134MP0005085_abnormal_gallbladder_physiolo0.72673844
135MP0002933_joint_inflammation0.72482193
136MP0005388_respiratory_system_phenotype0.72061678
137MP0002133_abnormal_respiratory_system0.72061678
138MP0010771_integument_phenotype0.71490743
139MP0000249_abnormal_blood_vessel0.70468237
140MP0006082_CNS_inflammation0.70157525
141MP0010329_abnormal_lipoprotein_level0.69690136
142MP0000733_abnormal_muscle_development0.69216259
143MP0006138_congestive_heart_failure0.68288339
144MP0003448_altered_tumor_morphology0.66068590
145MP0001915_intracranial_hemorrhage0.65982115
146MP0001819_abnormal_immune_cell0.65583485
147MP0001765_abnormal_ion_homeostasis0.64400815
148MP0001984_abnormal_olfaction0.63847117
149MP0000003_abnormal_adipose_tissue0.63143696
150MP0005360_urolithiasis0.60814778
151MP0003137_abnormal_impulse_conducting0.59142044
152MP0005584_abnormal_enzyme/coenzyme_acti0.56739243
153MP0003191_abnormal_cellular_cholesterol0.56574411
154MP0004233_abnormal_muscle_weight0.56081780
155MP0004142_abnormal_muscle_tone0.55536898
156MP0009840_abnormal_foam_cell0.55375920
157MP0004087_abnormal_muscle_fiber0.55042461
158MP0001348_abnormal_lacrimal_gland0.54860737
159MP0002089_abnormal_postnatal_growth/wei0.53646028
160MP0002118_abnormal_lipid_homeostasis0.52334706
161MP0005058_abnormal_lysosome_morphology0.51665486
162MP0003252_abnormal_bile_duct0.51315562
163MP0004484_altered_response_of0.48841330
164MP0005448_abnormal_energy_balance0.48458411
165MP0005645_abnormal_hypothalamus_physiol0.48235195
166MP0004185_abnormal_adipocyte_glucose0.48213942
167MP0005375_adipose_tissue_phenotype0.46748090

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.95396517
2Focal motor seizures (HP:0011153)5.32946877
3Focal seizures (HP:0007359)4.52553947
4Action tremor (HP:0002345)4.16962321
5Visual hallucinations (HP:0002367)4.04276755
6Abnormality of the lower motor neuron (HP:0002366)3.45388173
7Annular pancreas (HP:0001734)3.44653268
8Supranuclear gaze palsy (HP:0000605)3.40172814
9Ankle clonus (HP:0011448)3.39874531
10Impaired vibration sensation in the lower limbs (HP:0002166)3.24440009
11Postural instability (HP:0002172)3.22244655
12Depression (HP:0000716)3.17699400
13Torticollis (HP:0000473)3.16569243
14Impaired social interactions (HP:0000735)3.15975877
15Abnormal social behavior (HP:0012433)3.15975877
16Dysmetric saccades (HP:0000641)3.09846696
17Poor eye contact (HP:0000817)3.07692588
18Urinary bladder sphincter dysfunction (HP:0002839)3.00742782
19Resting tremor (HP:0002322)2.96652455
20Dysdiadochokinesis (HP:0002075)2.93735414
21Ventricular fibrillation (HP:0001663)2.90591563
22Broad face (HP:0000283)2.87997712
23Dysmetria (HP:0001310)2.86239904
24Hemiplegia (HP:0002301)2.85326611
25Urinary urgency (HP:0000012)2.83552035
26Intention tremor (HP:0002080)2.82450197
27Bundle branch block (HP:0011710)2.80867407
28Progressive cerebellar ataxia (HP:0002073)2.79444444
29Focal dystonia (HP:0004373)2.79388087
30Generalized tonic-clonic seizures (HP:0002069)2.75663479
31Pointed chin (HP:0000307)2.72940567
32Eczematoid dermatitis (HP:0000976)2.72397112
33Papilledema (HP:0001085)2.69318171
34Protrusio acetabuli (HP:0003179)2.68839792
35Epileptic encephalopathy (HP:0200134)2.68551975
36Anxiety (HP:0000739)2.68475848
37Absence seizures (HP:0002121)2.60232155
38Craniofacial dystonia (HP:0012179)2.60114925
39Distal upper limb amyotrophy (HP:0007149)2.59026312
40Upper limb amyotrophy (HP:0009129)2.59026312
41Insomnia (HP:0100785)2.58103059
42Atonic seizures (HP:0010819)2.52643025
43Febrile seizures (HP:0002373)2.52330562
44Increased IgE level (HP:0003212)2.49833669
45Lower limb amyotrophy (HP:0007210)2.49560364
46Gaze-evoked nystagmus (HP:0000640)2.49093201
47Cerebral inclusion bodies (HP:0100314)2.47559209
48Ankyloglossia (HP:0010296)2.42396293
49Impaired smooth pursuit (HP:0007772)2.40822360
50Spastic gait (HP:0002064)2.39576973
51Neurofibrillary tangles (HP:0002185)2.39057212
52Dialeptic seizures (HP:0011146)2.38639649
53Abnormal eating behavior (HP:0100738)2.36824549
54Genetic anticipation (HP:0003743)2.32972322
55Stereotypic behavior (HP:0000733)2.32161145
56Truncal ataxia (HP:0002078)2.30822741
57Scanning speech (HP:0002168)2.29957203
58Megalencephaly (HP:0001355)2.28862733
59Broad-based gait (HP:0002136)2.26949624
60Hyperacusis (HP:0010780)2.25778485
61Bradykinesia (HP:0002067)2.25680412
62Impaired vibratory sensation (HP:0002495)2.25286279
63Abnormality of the periventricular white matter (HP:0002518)2.24952565
64Thin bony cortex (HP:0002753)2.24778077
65Status epilepticus (HP:0002133)2.24579977
66Atrophic scars (HP:0001075)2.23976282
67Flat acetabular roof (HP:0003180)2.21609549
68Achilles tendon contracture (HP:0001771)2.20769768
69Shallow orbits (HP:0000586)2.18150766
70Hemorrhage of the eye (HP:0011885)2.17266456
71Abnormality of the Achilles tendon (HP:0005109)2.17151718
72Polygenic inheritance (HP:0010982)2.16357160
73Abnormality of nail color (HP:0100643)2.15837290
74Mutism (HP:0002300)2.12855659
75Abnormality of ocular smooth pursuit (HP:0000617)2.12783806
76Milia (HP:0001056)2.11957264
77Termporal pattern (HP:0011008)2.10950114
78Insidious onset (HP:0003587)2.10950114
79Dysostosis multiplex (HP:0000943)2.10521209
80Increased connective tissue (HP:0009025)2.10440741
81Macroorchidism (HP:0000053)2.10173547
82Neuronal loss in central nervous system (HP:0002529)2.09622326
83Heart block (HP:0012722)2.07577509
84Atrioventricular block (HP:0001678)2.07177382
85Segmental peripheral demyelination/remyelination (HP:0003481)2.06826052
86Rapidly progressive (HP:0003678)2.05968706
87Clonus (HP:0002169)2.05467456
88Fragile skin (HP:0001030)2.05236529
89Thick nail (HP:0001805)2.04102305
90Onion bulb formation (HP:0003383)2.04000573
91Premature rupture of membranes (HP:0001788)2.02664174
92Distal lower limb muscle weakness (HP:0009053)2.01862968
93Interstitial pulmonary disease (HP:0006530)2.01790623
94Aneurysm (HP:0002617)2.01116163
95Cervical subluxation (HP:0003308)1.99750544
96Lower limb muscle weakness (HP:0007340)1.98722409
97Cellulitis (HP:0100658)1.97662674
98Abnormality of saccadic eye movements (HP:0000570)1.97609671
99Disproportionate tall stature (HP:0001519)1.97387240
100Arterial tortuosity (HP:0005116)1.97349385
101Lower limb asymmetry (HP:0100559)1.97216216
102Vertebral compression fractures (HP:0002953)1.96727774
103Abnormality of the fingertips (HP:0001211)1.95441213
104Obstructive sleep apnea (HP:0002870)1.93570692
105Deep venous thrombosis (HP:0002625)1.92341959
106Abnormal atrioventricular conduction (HP:0005150)1.92316820
107Turricephaly (HP:0000262)1.91832272
108Systemic lupus erythematosus (HP:0002725)1.91809571
109Spastic tetraparesis (HP:0001285)1.90321325
110Abnormality of oral frenula (HP:0000190)1.87358617
111Cerebral aneurysm (HP:0004944)1.87084686
112Abnormal EKG (HP:0003115)1.86079949
113Bronchomalacia (HP:0002780)1.85953771
114Prolonged QT interval (HP:0001657)1.85945282
115Elfin facies (HP:0004428)1.85536019
116Rigidity (HP:0002063)1.85325961
117Diplopia (HP:0000651)1.84556850
118Abnormality of binocular vision (HP:0011514)1.84556850
119Vascular tortuosity (HP:0004948)1.84286539
120Urinary glycosaminoglycan excretion (HP:0003541)1.82776184
121Mucopolysacchariduria (HP:0008155)1.82776184
122Distal lower limb amyotrophy (HP:0008944)1.81772064
123Hammertoe (HP:0001765)1.80656502
124Tetraplegia (HP:0002445)1.80646963
125Dilatation of the ascending aorta (HP:0005111)1.80095162
126Slow saccadic eye movements (HP:0000514)1.79280852
127Malnutrition (HP:0004395)1.78331869
128Hyperparathyroidism (HP:0000843)1.76605053
129Amblyopia (HP:0000646)1.76119389
130Axonal loss (HP:0003447)1.75108058
131Hypercortisolism (HP:0001578)1.74321974
132Hemiparesis (HP:0001269)1.73202219
133Mitral regurgitation (HP:0001653)1.72965073
134Abnormality of macrophages (HP:0004311)1.72696008
135Gingivitis (HP:0000230)1.72095865
136Difficulty running (HP:0009046)1.71511692
137Advanced eruption of teeth (HP:0006288)1.71358755
138Ulnar bowing (HP:0003031)1.71236268
139Centrally nucleated skeletal muscle fibers (HP:0003687)1.71099928
140Abnormality of mucopolysaccharide metabolism (HP:0011020)1.70486108
141Abnormality of polysaccharide metabolism (HP:0011012)1.70486108
142Abnormality of glycosaminoglycan metabolism (HP:0004371)1.70486108
143Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.70401317
144Stridor (HP:0010307)1.70366588
145Neoplasm of the heart (HP:0100544)1.70139529
146Increased cerebral lipofuscin (HP:0011813)1.70016081
147Amyloidosis (HP:0011034)1.68705422
148Hand muscle atrophy (HP:0009130)1.68090689
149Abnormal blistering of the skin (HP:0008066)1.68040863
150Postural tremor (HP:0002174)1.67683446
151Spinal canal stenosis (HP:0003416)1.67665358
152Right ventricular cardiomyopathy (HP:0011663)1.66731636
153Increased variability in muscle fiber diameter (HP:0003557)1.64846069
154Colitis (HP:0002583)1.63158753
155Peripheral hypomyelination (HP:0007182)1.62979555
156Aortic aneurysm (HP:0004942)1.61876731
157Apathy (HP:0000741)1.61547560
158Long palpebral fissure (HP:0000637)1.60695012
159Plantar hyperkeratosis (HP:0007556)1.60095956
160Abnormality of complement system (HP:0005339)1.60047063
161Emphysema (HP:0002097)1.59868614
162Abnormality of the salivary glands (HP:0010286)1.59780874
163Loss of speech (HP:0002371)1.57187042
164Purpura (HP:0000979)1.56650993
165Nuclear cataract (HP:0100018)1.56617836
166Alopecia of scalp (HP:0002293)1.55204973
167Mildly elevated creatine phosphokinase (HP:0008180)1.54874829
168Nail dystrophy (HP:0008404)1.54058486
169Wormian bones (HP:0002645)1.53721623
170Decreased motor nerve conduction velocity (HP:0003431)1.53145596
171Difficulty climbing stairs (HP:0003551)1.52273382
172Polycythemia (HP:0001901)1.51681949
173Distal sensory impairment (HP:0002936)1.51301803

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.73854717
2MAP3K93.61528087
3NTRK33.44975249
4PRKD33.02800202
5DAPK22.88755714
6KSR22.79605661
7ERN12.73524742
8SMG12.45368461
9CAMKK12.34785247
10PAK62.27074123
11CDK122.19864720
12TRIB32.18562117
13NTRK11.99433808
14MINK11.98150209
15MAP3K131.86368967
16RIPK11.85969903
17TAOK11.79037632
18MAP3K41.78923529
19RIPK41.76696253
20TYRO31.76270810
21NTRK21.71210810
22MAP3K21.67643104
23STK381.64969597
24MST1R1.59178609
25SIK21.52008871
26EPHA21.47234027
27CDK51.41354659
28FES1.39292676
29PRKCH1.36171825
30IRAK31.28327407
31DAPK11.28095725
32ALK1.26747823
33MAP2K41.26744338
34KSR11.26285432
35MAP2K31.24624653
36MAP4K11.21432994
37RET1.20808209
38MARK11.18450365
39LMTK21.16661384
40PKN21.15592964
41TYK21.15573754
42TTN1.14720252
43MAP3K31.14229972
44MAP3K71.13412165
45SGK31.07219016
46ZAP701.05485736
47STK111.00403766
48PDK10.99900893
49FGFR30.98548712
50PDPK10.98002994
51MAP3K10.96567293
52PRPF4B0.95543061
53MAP3K60.93815738
54CAMK10.93539973
55ARAF0.92859018
56PINK10.92647056
57PDGFRA0.92484991
58MARK20.91347150
59CAMK1G0.89378111
60ICK0.88937985
61DMPK0.86639164
62CAMKK20.86241412
63SGK4940.85068773
64SGK2230.85068773
65MAPK120.84284613
66UHMK10.83900928
67RAF10.83636934
68BMX0.82807715
69BLK0.82580299
70SIK30.81987173
71PTK2B0.81381977
72MAP3K110.81246578
73MTOR0.81168825
74TAOK20.81107789
75MAP3K100.80178802
76NEK10.75599304
77MET0.74309605
78CDC42BPA0.73901408
79TESK10.72444693
80JAK30.72102627
81SGK10.72027167
82PRKCG0.71655164
83MAP3K140.70874285
84CSK0.70729611
85CAMK40.70728697
86WNK10.70598188
87PHKG20.69599989
88PHKG10.69599989
89GRK50.69412941
90PAK40.68498452
91SGK20.67562012
92HIPK20.67432832
93MAP2K70.66228307
94DDR20.65463907
95PAK30.65113402
96TNK20.64496333
97GRK60.63955585
98FGR0.62748383
99TBK10.62200551
100SCYL20.61850367
101PRKD20.61756924
102FGFR20.60734081
103CDK150.59423564
104PRKG20.59418507
105MAPK70.58966618
106FYN0.57746569
107NEK60.57277587
108RPS6KA30.56329609
109CDK180.55815013
110JAK10.55552148
111MAPK110.52959039
112DAPK30.52689832
113CAMK2A0.52264852
114IRAK20.51844954
115PTK60.51750413
116MAP2K10.50971580
117PRKCZ0.50962248
118LATS20.50862355
119CDK140.50052049
120CDK11A0.50028643
121PRKD10.48501287
122JAK20.48057546
123PTK20.48026667
124RPS6KL10.47951284
125RPS6KC10.47951284
126PDGFRB0.47465671
127IRAK40.46901219
128CAMK1D0.46791568
129CDK190.45866348
130CSF1R0.45765800
131MAPK100.45672145
132TGFBR20.43298492
133FER0.42986119
134CAMK2B0.42504987
135EEF2K0.42504862
136EPHB10.40941873
137SIK10.39866034
138TNIK0.37993917
139HCK0.37936557
140MAP2K20.37378388
141RPS6KA20.36227072
142FGFR40.36124753

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.11451999
2Olfactory transduction_Homo sapiens_hsa047402.60638992
3Synaptic vesicle cycle_Homo sapiens_hsa047212.34084627
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.20995096
5Circadian entrainment_Homo sapiens_hsa047132.19545983
6Long-term potentiation_Homo sapiens_hsa047202.18465588
7Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.09345139
8GABAergic synapse_Homo sapiens_hsa047272.03132333
9Glutamatergic synapse_Homo sapiens_hsa047242.02586250
10Nicotine addiction_Homo sapiens_hsa050332.01906973
11Other glycan degradation_Homo sapiens_hsa005111.97268244
12Morphine addiction_Homo sapiens_hsa050321.94369161
13Amphetamine addiction_Homo sapiens_hsa050311.93721017
14Salivary secretion_Homo sapiens_hsa049701.88638103
15Gastric acid secretion_Homo sapiens_hsa049711.87057252
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.79933511
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.76061852
18Cholinergic synapse_Homo sapiens_hsa047251.69253334
19Dopaminergic synapse_Homo sapiens_hsa047281.66673829
20Insulin secretion_Homo sapiens_hsa049111.64847871
21Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.60710652
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.60095470
23Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.54904542
24Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.53207686
25Cocaine addiction_Homo sapiens_hsa050301.51903219
26Oxytocin signaling pathway_Homo sapiens_hsa049211.47738171
27Acute myeloid leukemia_Homo sapiens_hsa052211.46973403
28Renin secretion_Homo sapiens_hsa049241.44317570
29GnRH signaling pathway_Homo sapiens_hsa049121.39940604
30Type II diabetes mellitus_Homo sapiens_hsa049301.35310652
31Notch signaling pathway_Homo sapiens_hsa043301.34713371
32B cell receptor signaling pathway_Homo sapiens_hsa046621.30130179
33Osteoclast differentiation_Homo sapiens_hsa043801.27735665
34Calcium signaling pathway_Homo sapiens_hsa040201.26412578
35Glioma_Homo sapiens_hsa052141.25549081
36Phosphatidylinositol signaling system_Homo sapiens_hsa040701.19592862
37AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.19373170
38Long-term depression_Homo sapiens_hsa047301.17444414
39Bile secretion_Homo sapiens_hsa049761.16936631
40Gap junction_Homo sapiens_hsa045401.16848260
41Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.15971138
42cAMP signaling pathway_Homo sapiens_hsa040241.15938887
43Arginine biosynthesis_Homo sapiens_hsa002201.15783835
44Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.13641779
45Glycosaminoglycan degradation_Homo sapiens_hsa005311.12982044
46Estrogen signaling pathway_Homo sapiens_hsa049151.10643561
47Pancreatic cancer_Homo sapiens_hsa052121.08311405
48Leukocyte transendothelial migration_Homo sapiens_hsa046701.07967400
49Dorso-ventral axis formation_Homo sapiens_hsa043201.06441410
50Phospholipase D signaling pathway_Homo sapiens_hsa040721.00539628
51Focal adhesion_Homo sapiens_hsa045100.99107787
52Leishmaniasis_Homo sapiens_hsa051400.95271506
53Taste transduction_Homo sapiens_hsa047420.95211335
54cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95162863
55ErbB signaling pathway_Homo sapiens_hsa040120.94878328
56Toxoplasmosis_Homo sapiens_hsa051450.94343086
57Bladder cancer_Homo sapiens_hsa052190.92533417
58Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.88273516
59Toll-like receptor signaling pathway_Homo sapiens_hsa046200.88039103
60Carbohydrate digestion and absorption_Homo sapiens_hsa049730.86792279
61VEGF signaling pathway_Homo sapiens_hsa043700.86416670
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86149300
63Serotonergic synapse_Homo sapiens_hsa047260.86121177
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.85734818
65Dilated cardiomyopathy_Homo sapiens_hsa054140.84999334
66Vascular smooth muscle contraction_Homo sapiens_hsa042700.84865315
67Melanogenesis_Homo sapiens_hsa049160.84734082
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.83872480
69Hepatitis C_Homo sapiens_hsa051600.83809768
70Tuberculosis_Homo sapiens_hsa051520.83536087
71mTOR signaling pathway_Homo sapiens_hsa041500.83434967
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.82036186
73T cell receptor signaling pathway_Homo sapiens_hsa046600.81896371
74Thyroid hormone synthesis_Homo sapiens_hsa049180.80730483
75Pancreatic secretion_Homo sapiens_hsa049720.80317608
76Fructose and mannose metabolism_Homo sapiens_hsa000510.80153077
77Lysosome_Homo sapiens_hsa041420.79961785
78Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.79917411
79Non-small cell lung cancer_Homo sapiens_hsa052230.79883502
80TNF signaling pathway_Homo sapiens_hsa046680.79857961
81Cyanoamino acid metabolism_Homo sapiens_hsa004600.79820847
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78014491
83ECM-receptor interaction_Homo sapiens_hsa045120.77642792
84Thyroid cancer_Homo sapiens_hsa052160.77291198
85Staphylococcus aureus infection_Homo sapiens_hsa051500.76959994
86HIF-1 signaling pathway_Homo sapiens_hsa040660.75870441
87Adherens junction_Homo sapiens_hsa045200.73846223
88Choline metabolism in cancer_Homo sapiens_hsa052310.73210193
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.73048459
90Rap1 signaling pathway_Homo sapiens_hsa040150.69764666
91Pertussis_Homo sapiens_hsa051330.69079941
92Axon guidance_Homo sapiens_hsa043600.67302045
93Influenza A_Homo sapiens_hsa051640.67047615
94Glucagon signaling pathway_Homo sapiens_hsa049220.65765953
95Endocytosis_Homo sapiens_hsa041440.64965975
96Hepatitis B_Homo sapiens_hsa051610.64228157
97MAPK signaling pathway_Homo sapiens_hsa040100.63990084
98Small cell lung cancer_Homo sapiens_hsa052220.63946881
99Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63763139
100Salmonella infection_Homo sapiens_hsa051320.62298777
101Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.62111033
102AMPK signaling pathway_Homo sapiens_hsa041520.60744642
103Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59933476
104Apoptosis_Homo sapiens_hsa042100.58580828
105Galactose metabolism_Homo sapiens_hsa000520.58533731
106Primary bile acid biosynthesis_Homo sapiens_hsa001200.57585210
107Insulin signaling pathway_Homo sapiens_hsa049100.57358370
108Adipocytokine signaling pathway_Homo sapiens_hsa049200.56847792
109Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56808399
110Endometrial cancer_Homo sapiens_hsa052130.56751071
111Prion diseases_Homo sapiens_hsa050200.56430396
112Chemokine signaling pathway_Homo sapiens_hsa040620.56260018
113Colorectal cancer_Homo sapiens_hsa052100.55666847
114Inositol phosphate metabolism_Homo sapiens_hsa005620.54712990
115Vibrio cholerae infection_Homo sapiens_hsa051100.54701127
116Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.54623059
117Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.52818981
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.51002054
119Insulin resistance_Homo sapiens_hsa049310.50821513
120Platelet activation_Homo sapiens_hsa046110.49544935
121Renal cell carcinoma_Homo sapiens_hsa052110.47495587
122Ras signaling pathway_Homo sapiens_hsa040140.46008289
123Collecting duct acid secretion_Homo sapiens_hsa049660.45245473
124Oocyte meiosis_Homo sapiens_hsa041140.43574011
125Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43458249
1262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.43307719
127Central carbon metabolism in cancer_Homo sapiens_hsa052300.43092918
128Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.42091236
129Fatty acid biosynthesis_Homo sapiens_hsa000610.41515457
130Prolactin signaling pathway_Homo sapiens_hsa049170.40724385
131Butanoate metabolism_Homo sapiens_hsa006500.39887392
132Chronic myeloid leukemia_Homo sapiens_hsa052200.38796140
133Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.37951319
134Proteoglycans in cancer_Homo sapiens_hsa052050.37089663
135Regulation of actin cytoskeleton_Homo sapiens_hsa048100.35277827
136Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.33161699
137Amoebiasis_Homo sapiens_hsa051460.33004072
138Glycerolipid metabolism_Homo sapiens_hsa005610.31622362
139Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.31192413
140Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.30507837

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