MIER2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of translational fidelity (GO:0006450)6.23179560
2cell migration involved in heart development (GO:0060973)4.72888892
3regulation of Wnt signaling pathway involved in heart development (GO:0003307)4.26301216
4protein localization to kinetochore (GO:0034501)4.23792264
5histone H4-K12 acetylation (GO:0043983)4.22369864
6immunoglobulin mediated immune response (GO:0016064)4.09624825
7apoptotic process involved in morphogenesis (GO:0060561)4.02537883
8protein insertion into membrane (GO:0051205)4.00347087
9semaphorin-plexin signaling pathway (GO:0071526)3.95306928
10planar cell polarity pathway involved in neural tube closure (GO:0090179)3.91631523
11cell-cell junction maintenance (GO:0045217)3.91423036
12protein heterotrimerization (GO:0070208)3.86825289
13tooth mineralization (GO:0034505)3.81625409
14negative regulation of cell fate specification (GO:0009996)3.78494112
15histone H2A monoubiquitination (GO:0035518)3.78345564
16negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.74167224
17regulation of gene silencing by RNA (GO:0060966)3.73384931
18regulation of posttranscriptional gene silencing (GO:0060147)3.73384931
19regulation of gene silencing by miRNA (GO:0060964)3.73384931
20DNA unwinding involved in DNA replication (GO:0006268)3.72125050
21folic acid-containing compound biosynthetic process (GO:0009396)3.70666182
22cardiac ventricle formation (GO:0003211)3.66517145
23regulation of translational elongation (GO:0006448)3.65566907
24mannose metabolic process (GO:0006013)3.64335379
25regulation of chromatin binding (GO:0035561)3.59200780
26positive regulation of B cell differentiation (GO:0045579)3.59141491
27DNA deamination (GO:0045006)3.58485399
28heterochromatin organization (GO:0070828)3.57030876
29regulation of hippo signaling (GO:0035330)3.53601486
30B cell mediated immunity (GO:0019724)3.51979556
31DNA duplex unwinding (GO:0032508)3.50966406
32negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.49348765
33histone H2A acetylation (GO:0043968)3.48777544
34negative regulation of cell size (GO:0045792)3.48420601
35DNA geometric change (GO:0032392)3.48115303
36intracellular estrogen receptor signaling pathway (GO:0030520)3.44477322
37regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.43910236
38positive regulation of histone deacetylation (GO:0031065)3.41244381
39cell migration in hindbrain (GO:0021535)3.40494413
40apoptotic process involved in development (GO:1902742)3.40249092
41IMP biosynthetic process (GO:0006188)3.39363997
42response to acidic pH (GO:0010447)3.35596859
43regulation of DNA damage checkpoint (GO:2000001)3.35286253
44nucleobase biosynthetic process (GO:0046112)3.34271578
45peptidyl-lysine dimethylation (GO:0018027)3.31799745
46folic acid metabolic process (GO:0046655)3.30569916
47mitotic nuclear envelope disassembly (GO:0007077)3.29618451
48negative regulation of cAMP-mediated signaling (GO:0043951)3.28289504
49mitotic metaphase plate congression (GO:0007080)3.28117893
50atrioventricular valve morphogenesis (GO:0003181)3.26986429
51cardiac chamber formation (GO:0003207)3.26031872
52cellular anion homeostasis (GO:0030002)3.25152240
53cell migration involved in gastrulation (GO:0042074)3.23867801
54IMP metabolic process (GO:0046040)3.22879346
55adherens junction assembly (GO:0034333)3.22229298
56chromatin assembly (GO:0031497)3.20550332
57peptidyl-arginine omega-N-methylation (GO:0035247)3.20331508
58DNA strand elongation involved in DNA replication (GO:0006271)3.16236061
59protein localization to chromosome, centromeric region (GO:0071459)3.15396180
60base-excision repair, AP site formation (GO:0006285)3.14546502
61DNA damage response, signal transduction resulting in transcription (GO:0042772)3.13837476
62pre-miRNA processing (GO:0031054)3.13628035
63mitotic chromosome condensation (GO:0007076)3.12521921
64negative regulation of mRNA processing (GO:0050686)3.12116238
65membrane disassembly (GO:0030397)3.11262793
66nuclear envelope disassembly (GO:0051081)3.11262793
67DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.10662565
68DNA replication initiation (GO:0006270)3.06297222
69activation of MAPKKK activity (GO:0000185)3.06131565
70pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.05076690
71DNA replication-dependent nucleosome organization (GO:0034723)3.03966622
72DNA replication-dependent nucleosome assembly (GO:0006335)3.03966622
73T cell apoptotic process (GO:0070231)3.03668205
74developmental programmed cell death (GO:0010623)3.03269509
75negative regulation of DNA-templated transcription, elongation (GO:0032785)3.02662165
76negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.02662165
77regulation of histone deacetylation (GO:0031063)3.02376330
78convergent extension (GO:0060026)3.02062351
79regulation of translational termination (GO:0006449)3.00893282
80cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.00799095
81dosage compensation (GO:0007549)3.00075402
82peptidyl-arginine methylation (GO:0018216)2.99387487
83peptidyl-arginine N-methylation (GO:0035246)2.99387487
84DNA strand elongation (GO:0022616)2.98464093
85negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.98313259
86cellular response to pH (GO:0071467)2.97402090
87histone H4-K5 acetylation (GO:0043981)2.96588840
88histone H4-K8 acetylation (GO:0043982)2.96588840
89negative regulation of RNA splicing (GO:0033119)2.96385420
903-UTR-mediated mRNA stabilization (GO:0070935)2.96288426
91positive regulation of CREB transcription factor activity (GO:0032793)2.93289388
92positive regulation of protein kinase C signaling (GO:0090037)2.92622542
93telomere maintenance via semi-conservative replication (GO:0032201)2.91251125
94mitotic G1 DNA damage checkpoint (GO:0031571)2.90746405
95chromatin assembly or disassembly (GO:0006333)2.89609398
96endothelial cell chemotaxis (GO:0035767)2.87745431
97mitotic sister chromatid segregation (GO:0000070)2.85462282
98regulation of telomerase activity (GO:0051972)2.84958988
99negative regulation of chromosome segregation (GO:0051985)2.84732712
100respiratory system process (GO:0003016)2.82810963
101negative regulation of histone methylation (GO:0031061)2.82779954
102pyrimidine nucleotide catabolic process (GO:0006244)2.82342877
103cell-substrate adherens junction assembly (GO:0007045)2.82144392
104focal adhesion assembly (GO:0048041)2.82144392
105negative regulation of macroautophagy (GO:0016242)2.81965614
106negative regulation of meiosis (GO:0045835)2.81626133
107mitochondrial DNA metabolic process (GO:0032042)2.80187232
108regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.79625475
109histone H2A ubiquitination (GO:0033522)2.79225232
110metaphase plate congression (GO:0051310)2.78476969
111histone arginine methylation (GO:0034969)2.77411399
112spliceosomal tri-snRNP complex assembly (GO:0000244)2.77336233
113positive regulation of endothelial cell apoptotic process (GO:2000353)2.76029798
114cochlea morphogenesis (GO:0090103)2.75611975
115paraxial mesoderm development (GO:0048339)2.75055516
116regulation of sister chromatid cohesion (GO:0007063)2.74616209
117lymphocyte apoptotic process (GO:0070227)2.74395641
118cell junction maintenance (GO:0034331)2.73650451
119regulation of G0 to G1 transition (GO:0070316)2.73179216
120regulation of DNA methylation (GO:0044030)2.72315416
121maturation of 5.8S rRNA (GO:0000460)2.72190718
122basement membrane organization (GO:0071711)2.71190338
123growth hormone secretion (GO:0030252)2.71004029
124DNA demethylation (GO:0080111)2.70996157
125regulation of mammary gland epithelial cell proliferation (GO:0033599)2.70496843
126negative regulation of telomere maintenance (GO:0032205)2.70273043
127base-excision repair (GO:0006284)2.68571149
128negative regulation of telomerase activity (GO:0051974)2.68382972
129chaperone mediated protein folding requiring cofactor (GO:0051085)2.68291310
130nucleosome disassembly (GO:0006337)2.67584568
131protein-DNA complex disassembly (GO:0032986)2.67584568
132ncRNA 3-end processing (GO:0043628)2.66657746
133snRNA metabolic process (GO:0016073)2.65655917
134negative regulation of mRNA metabolic process (GO:1903312)2.64811535
135nodal signaling pathway (GO:0038092)2.64590512
136snRNA processing (GO:0016180)2.64402212
137positive regulation of gene expression, epigenetic (GO:0045815)2.64106918
138negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.63982006
139negative regulation of sister chromatid segregation (GO:0033046)2.63982006
140negative regulation of mitotic sister chromatid separation (GO:2000816)2.63982006
141negative regulation of mitotic sister chromatid segregation (GO:0033048)2.63982006
142RNA localization (GO:0006403)2.63912302
143protein retention in ER lumen (GO:0006621)2.63617911
144establishment of apical/basal cell polarity (GO:0035089)2.63488545
145histone deubiquitination (GO:0016578)2.62983701
146regulation of cell fate specification (GO:0042659)2.62771868
147L-alpha-amino acid transmembrane transport (GO:1902475)2.62492054
148RNA stabilization (GO:0043489)2.62475780
149mRNA stabilization (GO:0048255)2.62475780
150somatic hypermutation of immunoglobulin genes (GO:0016446)2.61060386
151somatic diversification of immune receptors via somatic mutation (GO:0002566)2.61060386
152histone H4 acetylation (GO:0043967)2.60978036
153regulation of early endosome to late endosome transport (GO:2000641)2.59072744
154vascular endothelial growth factor signaling pathway (GO:0038084)2.58815462
155trophoblast giant cell differentiation (GO:0060707)2.58800160
156ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.58570591
157positive regulation of protein sumoylation (GO:0033235)2.58402223
158proline biosynthetic process (GO:0006561)2.58292558
159regulation of gene silencing (GO:0060968)2.57837035
160nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.57482693
161outflow tract septum morphogenesis (GO:0003148)2.56905921
162lung morphogenesis (GO:0060425)2.56282129
163cellular response to ATP (GO:0071318)2.56180825
164Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.53496281
165positive regulation of lymphocyte apoptotic process (GO:0070230)2.53327390
166retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.52179837
167virion attachment to host cell (GO:0019062)2.51164438
168adhesion of symbiont to host cell (GO:0044650)2.51164438
169leukocyte apoptotic process (GO:0071887)2.51161458
170adhesion of symbiont to host (GO:0044406)2.50232718
171neural tube development (GO:0021915)2.49756741
172cell-substrate junction assembly (GO:0007044)2.47096638
173heart field specification (GO:0003128)2.46704365
174secondary heart field specification (GO:0003139)2.46704365
175positive regulation of blood vessel endothelial cell migration (GO:0043536)2.46393301
176regulation of apoptotic process involved in morphogenesis (GO:1902337)2.43897624
177modulation by virus of host process (GO:0019054)2.43509375
178negative regulation of cell fate commitment (GO:0010454)2.43394294
179anatomical structure regression (GO:0060033)2.43157600
180cellular response to arsenic-containing substance (GO:0071243)2.40810773
181lymphangiogenesis (GO:0001946)2.39879420
182UV protection (GO:0009650)2.39235132
183response to pH (GO:0009268)2.38556529
184endothelial cell differentiation (GO:0045446)2.38146594
185maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.37482172

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.28541177
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.11959078
3MYC_22102868_ChIP-Seq_BL_Human3.22576547
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.16627128
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.10819108
6FOXM1_23109430_ChIP-Seq_U2OS_Human2.83199060
7RARG_19884340_ChIP-ChIP_MEFs_Mouse2.74248560
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.54759404
9* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.39998768
10VDR_21846776_ChIP-Seq_THP-1_Human2.31942861
11ERG_21242973_ChIP-ChIP_JURKAT_Human2.20309575
12THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.19542444
13* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.17701116
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.12390377
15NOTCH1_21737748_ChIP-Seq_TLL_Human2.11320127
16TP63_17297297_ChIP-ChIP_HaCaT_Human2.08695541
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.00525463
18MYC_19030024_ChIP-ChIP_MESCs_Mouse2.00410118
19ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.96106974
20TET1_21451524_ChIP-Seq_MESCs_Mouse1.96011321
21ZNF263_19887448_ChIP-Seq_K562_Human1.91383037
22CIITA_25753668_ChIP-Seq_RAJI_Human1.90439313
23TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.88653155
24XRN2_22483619_ChIP-Seq_HELA_Human1.87056827
25DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.85094289
26POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.77701754
27CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.72944833
28NELFA_20434984_ChIP-Seq_ESCs_Mouse1.71878924
29E2F4_17652178_ChIP-ChIP_JURKAT_Human1.70292747
30TCF7_22412390_ChIP-Seq_EML_Mouse1.69773734
31SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.68043792
32BCL6_27268052_Chip-Seq_Bcells_Human1.66157482
33ZFP281_18757296_ChIP-ChIP_E14_Mouse1.66004458
34* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.65386952
35SRY_22984422_ChIP-ChIP_TESTIS_Rat1.65200815
36KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.63783914
37ELK3_25401928_ChIP-Seq_HUVEC_Human1.63623090
38EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.63579113
39NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.62219318
40KDM2B_26808549_Chip-Seq_DND41_Human1.62132670
41STAT3_1855785_ChIP-Seq_MESCs_Mouse1.58285650
42KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.57530700
43CTCF_27219007_Chip-Seq_Bcells_Human1.57440240
44CTCF_27219007_Chip-Seq_ERYTHROID_Human1.57093578
45E2F1_21310950_ChIP-Seq_MCF-7_Human1.54685179
46SMC4_20622854_ChIP-Seq_HELA_Human1.54553192
47HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.54001741
48BCOR_27268052_Chip-Seq_Bcells_Human1.53568286
49SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.51166094
50ETS1_20019798_ChIP-Seq_JURKAT_Human1.50477351
51KDM2B_26808549_Chip-Seq_SUP-B15_Human1.50449068
52SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.50444571
53* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.50321593
54SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.50014870
55ZFX_18555785_ChIP-Seq_MESCs_Mouse1.49200572
56E2F1_20622854_ChIP-Seq_HELA_Human1.48457603
57GABP_19822575_ChIP-Seq_HepG2_Human1.48214214
58JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.47207058
59NANOG_18555785_ChIP-Seq_MESCs_Mouse1.45037694
60DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.44942813
61MYCN_18555785_ChIP-Seq_MESCs_Mouse1.42792784
62CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.41877421
63AR_21909140_ChIP-Seq_LNCAP_Human1.41292010
64SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.40805992
65* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.39477062
66CTCF_20526341_ChIP-Seq_ESCs_Human1.39370917
67CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.39107528
68CREB1_26743006_Chip-Seq_LNCaP_Human1.38822904
69KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.36007242
70YY1_22570637_ChIP-Seq_MALME-3M_Human1.35337266
71DNAJC2_21179169_ChIP-ChIP_NT2_Human1.34937848
72TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.33075573
73NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.33025950
74RARB_24833708_ChIP-Seq_LIVER_Mouse1.32944768
75EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.31609427
76CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.31599080
77DROSHA_22980978_ChIP-Seq_HELA_Human1.29472823
78CTCF_26484167_Chip-Seq_Bcells_Mouse1.29409141
79TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.28580011
80P68_20966046_ChIP-Seq_HELA_Human1.28148751
81LXR_22292898_ChIP-Seq_THP-1_Human1.28074066
82HIF1A_21447827_ChIP-Seq_MCF-7_Human1.27664058
83MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.27629045
84NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.26781924
85SA1_27219007_Chip-Seq_Bcells_Human1.25634279
86* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.25524811
87MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.25314433
88ESR1_15608294_ChIP-ChIP_MCF-7_Human1.25270750
89TP63_22573176_ChIP-Seq_HFKS_Human1.25088704
90UTX_26944678_Chip-Seq_JUKART_Human1.24390640
91ATF3_27146783_Chip-Seq_COLON_Human1.23551100
92SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.23069851
93MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.22178990
94RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.22018199
95RARA_24833708_ChIP-Seq_LIVER_Mouse1.21834342
96RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.20673950
97NANOG_21062744_ChIP-ChIP_HESCs_Human1.20007761
98TP53_20018659_ChIP-ChIP_R1E_Mouse1.18908847
99TTF2_22483619_ChIP-Seq_HELA_Human1.18187385
100TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.16631552
101DCP1A_22483619_ChIP-Seq_HELA_Human1.16482362
102SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.15653655
103* RACK7_27058665_Chip-Seq_MCF-7_Human1.15642185
104KDM5A_27292631_Chip-Seq_BREAST_Human1.15356505
105CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.14618013
106THAP11_20581084_ChIP-Seq_MESCs_Mouse1.14376899
107RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.14357267
108MAF_26560356_Chip-Seq_TH2_Human1.14246027
109FOXP3_21729870_ChIP-Seq_TREG_Human1.13548466
110E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.12208132
111TET1_21490601_ChIP-Seq_MESCs_Mouse1.12091977
112POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.11817541
113TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11806379
114NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.11547978
115* STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.10447761
116SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.10296585
117OCT4_19829295_ChIP-Seq_ESCs_Human1.10145509
118EST1_17652178_ChIP-ChIP_JURKAT_Human1.09825724
119ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.09669688
120NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.09268320
121MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.08335073
122KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.07551273
123KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.07551273
124KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.07551273
125STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.07485456
126CTCF_21964334_Chip-Seq_Bcells_Human1.06378719
127TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05807498
128MAF_26560356_Chip-Seq_TH1_Human1.05718439
129FOXP1_21924763_ChIP-Seq_HESCs_Human1.05409112
130KDM2B_26808549_Chip-Seq_JURKAT_Human1.05027686
131NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.04777654
132KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.04569715
133STAT6_21828071_ChIP-Seq_BEAS2B_Human1.04160477
134CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.04116408
135CTCF_18555785_ChIP-Seq_MESCs_Mouse1.03980524
136SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.03807500
137P300_27058665_Chip-Seq_ZR-75-30cells_Human1.03448763
138NCOR1_26117541_ChIP-Seq_K562_Human1.03167480
139SA1_27219007_Chip-Seq_ERYTHROID_Human1.03098525
140* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.02306121
141SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.01653836
142KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.01396653
143PHF8_20622854_ChIP-Seq_HELA_Human1.01311151
144ELF1_20517297_ChIP-Seq_JURKAT_Human1.01046699
145TP53_22127205_ChIP-Seq_IMR90_Human1.00787351
146* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.00208534
147VDR_24763502_ChIP-Seq_THP-1_Human1.00139886
148TP63_19390658_ChIP-ChIP_HaCaT_Human1.00055719
149TCF3_18692474_ChIP-Seq_MESCs_Mouse1.00010251
150SMC3_22415368_ChIP-Seq_MEFs_Mouse0.99804769
151SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.98882761
152TCF3_18692474_ChIP-Seq_MEFs_Mouse0.98158626
153KDM2B_26808549_Chip-Seq_K562_Human0.97854654
154SUZ12_27294783_Chip-Seq_ESCs_Mouse0.96328635
155PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.96017556
156* TP53_23651856_ChIP-Seq_MEFs_Mouse0.95981899
157GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95779512

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat4.10477664
2MP0005058_abnormal_lysosome_morphology3.41705553
3MP0003111_abnormal_nucleus_morphology3.15428331
4MP0003693_abnormal_embryo_hatching3.14419527
5MP0004957_abnormal_blastocyst_morpholog3.12217414
6MP0003077_abnormal_cell_cycle3.01190632
7MP0010094_abnormal_chromosome_stability2.95807777
8MP0002653_abnormal_ependyma_morphology2.94557740
9MP0003705_abnormal_hypodermis_morpholog2.83515915
10MP0003279_aneurysm2.66243766
11MP0001348_abnormal_lacrimal_gland2.40008193
12MP0004858_abnormal_nervous_system2.37602652
13MP0010030_abnormal_orbit_morphology2.32205857
14MP0000350_abnormal_cell_proliferation2.25804242
15MP0003123_paternal_imprinting2.24734245
16MP0008007_abnormal_cellular_replicative2.22461766
17MP0008058_abnormal_DNA_repair2.15853038
18MP0001730_embryonic_growth_arrest2.09318493
19MP0000490_abnormal_crypts_of2.05422552
20MP0006292_abnormal_olfactory_placode2.03847847
21MP0002396_abnormal_hematopoietic_system2.02174744
22MP0009384_cardiac_valve_regurgitation2.01416898
23MP0008438_abnormal_cutaneous_collagen2.00668359
24MP0005423_abnormal_somatic_nervous2.00663377
25MP0005076_abnormal_cell_differentiation1.95655706
26MP0004133_heterotaxia1.94792657
27MP0002089_abnormal_postnatal_growth/wei1.87371848
28MP0001849_ear_inflammation1.86763851
29MP0000013_abnormal_adipose_tissue1.85309600
30MP0001697_abnormal_embryo_size1.83040307
31MP0005075_abnormal_melanosome_morpholog1.82821721
32MP0002085_abnormal_embryonic_tissue1.82528362
33MP0004510_myositis1.82250493
34MP0002084_abnormal_developmental_patter1.77538738
35MP0009840_abnormal_foam_cell1.75115107
36MP0006072_abnormal_retinal_apoptosis1.72365823
37MP0010352_gastrointestinal_tract_polyps1.72325320
38MP0005257_abnormal_intraocular_pressure1.71531726
39MP0004808_abnormal_hematopoietic_stem1.63566507
40MP0005394_taste/olfaction_phenotype1.63175053
41MP0005499_abnormal_olfactory_system1.63175053
42MP0008789_abnormal_olfactory_epithelium1.63139407
43MP0001672_abnormal_embryogenesis/_devel1.62720051
44MP0005380_embryogenesis_phenotype1.62720051
45MP0001986_abnormal_taste_sensitivity1.62192272
46MP0008877_abnormal_DNA_methylation1.59769557
47MP0008932_abnormal_embryonic_tissue1.59745337
48MP0002249_abnormal_larynx_morphology1.58075950
49MP0003718_maternal_effect1.57925552
50MP0002080_prenatal_lethality1.57647212
51MP0000003_abnormal_adipose_tissue1.54754598
52MP0005451_abnormal_body_composition1.50303445
53MP0000767_abnormal_smooth_muscle1.49225427
54MP0003566_abnormal_cell_adhesion1.48427796
55MP0000750_abnormal_muscle_regeneration1.43539529
56MP0004272_abnormal_basement_membrane1.43379402
57MP0005023_abnormal_wound_healing1.42324143
58MP0005623_abnormal_meninges_morphology1.37996203
59MP0003984_embryonic_growth_retardation1.37614782
60MP0001542_abnormal_bone_strength1.36752895
61MP0008260_abnormal_autophagy1.34276247
62MP0004233_abnormal_muscle_weight1.34242497
63MP0002088_abnormal_embryonic_growth/wei1.34076036
64MP0010368_abnormal_lymphatic_system1.33418372
65MP0002019_abnormal_tumor_incidence1.30502544
66MP0005670_abnormal_white_adipose1.28168791
67MP0010307_abnormal_tumor_latency1.27202143
68MP0010234_abnormal_vibrissa_follicle1.27076178
69MP0004197_abnormal_fetal_growth/weight/1.26682978
70MP0003172_abnormal_lysosome_physiology1.26465096
71MP0003283_abnormal_digestive_organ1.25956706
72MP0002086_abnormal_extraembryonic_tissu1.25942863
73MP0005501_abnormal_skin_physiology1.25137929
74MP0003121_genomic_imprinting1.24637314
75MP0009053_abnormal_anal_canal1.24554612
76MP0001915_intracranial_hemorrhage1.22228951
77MP0002177_abnormal_outer_ear1.20618989
78MP0003567_abnormal_fetal_cardiomyocyte1.18645359
79MP0000313_abnormal_cell_death1.15855208
80MP0003119_abnormal_digestive_system1.14057911
81MP0001293_anophthalmia1.12446313
82MP0002234_abnormal_pharynx_morphology1.12292293
83MP0002116_abnormal_craniofacial_bone1.12119073
84MP0004185_abnormal_adipocyte_glucose1.12029429
85MP0005375_adipose_tissue_phenotype1.09972339
86MP0003699_abnormal_female_reproductive1.05863176
87MP0003453_abnormal_keratinocyte_physiol1.03817449
88MP0001119_abnormal_female_reproductive1.03609946
89MP0000733_abnormal_muscle_development1.03398139
90MP0000653_abnormal_sex_gland1.03100860
91MP0002932_abnormal_joint_morphology1.00889533
92MP0004145_abnormal_muscle_electrophysio0.99973519
93MP0004264_abnormal_extraembryonic_tissu0.99722074
94MP0002210_abnormal_sex_determination0.99472021
95MP0001545_abnormal_hematopoietic_system0.99433211
96MP0005397_hematopoietic_system_phenotyp0.99433211
97MP0000537_abnormal_urethra_morphology0.98490249
98MP0002796_impaired_skin_barrier0.97460070
99MP0003385_abnormal_body_wall0.96863089
100MP0001873_stomach_inflammation0.96368735
101MP0001145_abnormal_male_reproductive0.95681352
102MP0005390_skeleton_phenotype0.95136066
103MP0006054_spinal_hemorrhage0.94981016
104MP0000566_synostosis0.94781597
105MP0005621_abnormal_cell_physiology0.94463142
106MP0005595_abnormal_vascular_smooth0.94024401
107MP0002933_joint_inflammation0.93697150
108MP0003942_abnormal_urinary_system0.93081557
109MP0002092_abnormal_eye_morphology0.92664563
110MP0009278_abnormal_bone_marrow0.92245814
111MP0005174_abnormal_tail_pigmentation0.92105400
112MP0002111_abnormal_tail_morphology0.91520986
113MP0003315_abnormal_perineum_morphology0.91446631
114MP0000681_abnormal_thyroid_gland0.91375560
115MP0003763_abnormal_thymus_physiology0.91214583
116MP0001958_emphysema0.89322467
117MP0003436_decreased_susceptibility_to0.88518323
118MP0000678_abnormal_parathyroid_gland0.87963518
119MP0002998_abnormal_bone_remodeling0.87799747
120MP0002075_abnormal_coat/hair_pigmentati0.86906805
121MP0003755_abnormal_palate_morphology0.86559905
122MP0005384_cellular_phenotype0.86552284
123MP0000477_abnormal_intestine_morphology0.86333381
124MP0003935_abnormal_craniofacial_develop0.85948265
125MP0003861_abnormal_nervous_system0.84194570
126MP0009250_abnormal_appendicular_skeleto0.84123069
127MP0003115_abnormal_respiratory_system0.83482496
128MP0008057_abnormal_DNA_replication0.83414851
129MP0000428_abnormal_craniofacial_morphol0.82741423
130MP0005503_abnormal_tendon_morphology0.82365701
131MP0005508_abnormal_skeleton_morphology0.82029810
132MP0002114_abnormal_axial_skeleton0.81921986
133MP0000759_abnormal_skeletal_muscle0.81921164
134MP0000858_altered_metastatic_potential0.81886853
135MP0000703_abnormal_thymus_morphology0.81439536
136MP0009333_abnormal_splenocyte_physiolog0.81329240
137MP0003137_abnormal_impulse_conducting0.80636049
138MP0000751_myopathy0.79952824
139MP0001614_abnormal_blood_vessel0.79876325
140MP0003011_delayed_dark_adaptation0.78904730
141MP0000049_abnormal_middle_ear0.78807861
142MP0003091_abnormal_cell_migration0.78371614
143MP0002925_abnormal_cardiovascular_devel0.78122355
144MP0002269_muscular_atrophy0.77922476
145MP0008770_decreased_survivor_rate0.77607698
146MP0003937_abnormal_limbs/digits/tail_de0.77518151
147MP0000467_abnormal_esophagus_morphology0.77266916
148MP0009703_decreased_birth_body0.76186871
149MP0000470_abnormal_stomach_morphology0.75896020
150MP0008961_abnormal_basal_metabolism0.74648766
151MP0003938_abnormal_ear_development0.73512291
152MP0000432_abnormal_head_morphology0.73184002
153MP0000534_abnormal_ureter_morphology0.72508031
154MP0002113_abnormal_skeleton_development0.71169155
155MP0001299_abnormal_eye_distance/0.68069117
156MP0000462_abnormal_digestive_system0.67913188
157MP0002098_abnormal_vibrissa_morphology0.67239293
158MP0001529_abnormal_vocalization0.66120660
159MP0002822_catalepsy0.63993484
160MP0000163_abnormal_cartilage_morphology0.63965810
161MP0001270_distended_abdomen0.62789249
162MP0001502_abnormal_circadian_rhythm0.60342270
163MP0005167_abnormal_blood-brain_barrier0.59288644
164MP0004087_abnormal_muscle_fiber0.58450646
165MP0003646_muscle_fatigue0.56476815

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)7.72593592
2Premature rupture of membranes (HP:0001788)4.23057185
3Protrusio acetabuli (HP:0003179)4.08839213
4Premature skin wrinkling (HP:0100678)3.56586728
5Rib fusion (HP:0000902)3.55486184
6Obstructive sleep apnea (HP:0002870)3.52474831
7Progressive external ophthalmoplegia (HP:0000590)3.44286640
8Increased neuronal autofluorescent lipopigment (HP:0002074)3.40032015
9Ependymoma (HP:0002888)3.32542197
10Increased cerebral lipofuscin (HP:0011813)3.30088451
11Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.20897185
12Genu recurvatum (HP:0002816)3.12797318
13Selective tooth agenesis (HP:0001592)3.05314738
14Anterior segment dysgenesis (HP:0007700)3.01870835
15Hyperacusis (HP:0010780)2.97834766
16Cervical subluxation (HP:0003308)2.91514108
17Stridor (HP:0010307)2.89977686
18Bowel diverticulosis (HP:0005222)2.88929492
19Ankle contracture (HP:0006466)2.82637343
20Upper limb amyotrophy (HP:0009129)2.80810164
21Distal upper limb amyotrophy (HP:0007149)2.80810164
22Patellar aplasia (HP:0006443)2.78868247
23Deep palmar crease (HP:0006191)2.75699137
24Renal duplication (HP:0000075)2.74130855
25Neoplasm of the oral cavity (HP:0100649)2.72801269
26Severe visual impairment (HP:0001141)2.72566072
27Genetic anticipation (HP:0003743)2.70293556
28Easy fatigability (HP:0003388)2.68098737
29Intestinal fistula (HP:0100819)2.67254593
30Abnormal number of incisors (HP:0011064)2.61871027
31Vaginal fistula (HP:0004320)2.60073534
32Aplasia/Hypoplasia of the patella (HP:0006498)2.59460114
33Adactyly (HP:0009776)2.58453142
34Disproportionate tall stature (HP:0001519)2.57084061
35Abnormality of the nasal mucosa (HP:0000433)2.55363970
36Spinal rigidity (HP:0003306)2.54177580
37Rectal fistula (HP:0100590)2.53925899
38Rectovaginal fistula (HP:0000143)2.53925899
39Subacute progressive viral hepatitis (HP:0006572)2.50325746
40Medulloblastoma (HP:0002885)2.49859492
41Basal cell carcinoma (HP:0002671)2.49652792
42Cerebral aneurysm (HP:0004944)2.49163652
43J-shaped sella turcica (HP:0002680)2.46034380
44Abnormality of the astrocytes (HP:0100707)2.44928803
45Astrocytoma (HP:0009592)2.44928803
46Renovascular hypertension (HP:0100817)2.44129508
47Mildly elevated creatine phosphokinase (HP:0008180)2.43890779
48Long palpebral fissure (HP:0000637)2.42368685
49Retinal dysplasia (HP:0007973)2.41452238
50Abnormality of the columella (HP:0009929)2.41128984
51Colon cancer (HP:0003003)2.32927653
52Thrombocytosis (HP:0001894)2.32788912
53Abnormality of the aortic arch (HP:0012303)2.30508359
54Generalized amyotrophy (HP:0003700)2.27146936
55Shallow orbits (HP:0000586)2.25210737
56Abnormality of the anterior chamber (HP:0000593)2.24841095
57Fragile skin (HP:0001030)2.23083771
58Slender long bone (HP:0003100)2.21640440
59Insomnia (HP:0100785)2.20660016
60Megalocornea (HP:0000485)2.20197189
61Facial hemangioma (HP:0000329)2.19789942
62Congenital stationary night blindness (HP:0007642)2.16081612
63Joint stiffness (HP:0001387)2.15681985
64Blue sclerae (HP:0000592)2.15446990
65Hand muscle atrophy (HP:0009130)2.15217848
66Broad face (HP:0000283)2.12001524
67Autoimmune thrombocytopenia (HP:0001973)2.09997608
68Birth length less than 3rd percentile (HP:0003561)2.08734218
69Broad palm (HP:0001169)2.07405368
70Poikiloderma (HP:0001029)2.06840117
71Difficulty climbing stairs (HP:0003551)2.06547217
72Chin dimple (HP:0010751)2.06430597
73Congenital hip dislocation (HP:0001374)2.05859650
74Gastrointestinal carcinoma (HP:0002672)2.05426196
75Malignant gastrointestinal tract tumors (HP:0006749)2.05426196
76Nonimmune hydrops fetalis (HP:0001790)2.05380471
77Bladder diverticulum (HP:0000015)2.05312272
78Slender build (HP:0001533)2.04991654
79Breast hypoplasia (HP:0003187)2.04920473
80Shawl scrotum (HP:0000049)2.04138524
81Rhabdomyosarcoma (HP:0002859)2.03857363
82Preauricular skin tag (HP:0000384)2.02570122
83Biconcave vertebral bodies (HP:0004586)2.02342719
84Ectopia lentis (HP:0001083)2.01878992
85Annular pancreas (HP:0001734)2.01792306
86Increased nuchal translucency (HP:0010880)2.01471685
87Pointed chin (HP:0000307)2.01248047
88Deviation of the thumb (HP:0009603)1.98948206
89Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.98235983
90Neoplasm of striated muscle (HP:0009728)1.98072246
91Leiomyosarcoma (HP:0100243)1.95717413
92Uterine leiomyosarcoma (HP:0002891)1.95717413
93Hypoplasia of the iris (HP:0007676)1.94990237
94Elfin facies (HP:0004428)1.94956070
95Down-sloping shoulders (HP:0200021)1.94385726
96Skin tags (HP:0010609)1.94254420
97Hypoventilation (HP:0002791)1.94178930
98Overriding aorta (HP:0002623)1.93763705
99Increased IgM level (HP:0003496)1.93458858
100Spina bifida occulta (HP:0003298)1.92662862
101Nasal polyposis (HP:0100582)1.92649040
102Abnormality of the lower motor neuron (HP:0002366)1.92320489
103Vertebral fusion (HP:0002948)1.91736934
104Overlapping toe (HP:0001845)1.91313941
105Proximal placement of thumb (HP:0009623)1.91159119
106Albinism (HP:0001022)1.90828183
107Sparse lateral eyebrow (HP:0005338)1.90501164
108Male infertility (HP:0003251)1.89923965
109Thin ribs (HP:0000883)1.89909560
110Ulnar bowing (HP:0003031)1.89753147
111Cafe-au-lait spot (HP:0000957)1.89635336
112Abnormality of abdominal situs (HP:0011620)1.89504496
113Abdominal situs inversus (HP:0003363)1.89504496
114Hyperlipoproteinemia (HP:0010980)1.87936861
115Emphysema (HP:0002097)1.87711079
116Myelodysplasia (HP:0002863)1.87594808
117Long eyelashes (HP:0000527)1.86646254
118Amaurosis fugax (HP:0100576)1.86191299
119Broad distal phalanx of finger (HP:0009836)1.85755469
120Skull defect (HP:0001362)1.82495469
121Abnormality of the acetabulum (HP:0003170)1.81577554
122Breech presentation (HP:0001623)1.81493332
123Pendular nystagmus (HP:0012043)1.80534809
124Natal tooth (HP:0000695)1.79756178
125Degeneration of anterior horn cells (HP:0002398)1.79319647
126Abnormality of the anterior horn cell (HP:0006802)1.79319647
127Squamous cell carcinoma (HP:0002860)1.79217404
128Neoplasm of the pancreas (HP:0002894)1.78193173
129Trismus (HP:0000211)1.77580025
130Atrophic scars (HP:0001075)1.77155015
131Prominent nose (HP:0000448)1.76965141
132Increased connective tissue (HP:0009025)1.76188183
133Pancytopenia (HP:0001876)1.76159615
134Bronchomalacia (HP:0002780)1.75310990
135Abnormality of mucopolysaccharide metabolism (HP:0011020)1.75104902
136Abnormality of polysaccharide metabolism (HP:0011012)1.75104902
137Abnormality of glycosaminoglycan metabolism (HP:0004371)1.75104902
138Multiple enchondromatosis (HP:0005701)1.74954560
139Ureteral duplication (HP:0000073)1.74566920
140Vertebral arch anomaly (HP:0008438)1.73376897
141Clumsiness (HP:0002312)1.72784395
142Hypoplasia of the capital femoral epiphysis (HP:0003090)1.72451278
143Abnormality of dentin (HP:0010299)1.72401355
144Progressive muscle weakness (HP:0003323)1.72105898
145Nephroblastoma (Wilms tumor) (HP:0002667)1.71586420
146Dysostosis multiplex (HP:0000943)1.71487836
147Short humerus (HP:0005792)1.71297562
148Chromsome breakage (HP:0040012)1.69926087
149Narrow nasal bridge (HP:0000446)1.69562903
150Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.69536052
151Short 4th metacarpal (HP:0010044)1.69536052
152External ophthalmoplegia (HP:0000544)1.69110072
153Abnormality of the calcaneus (HP:0008364)1.68909666
154Achilles tendon contracture (HP:0001771)1.68825756
155Enlarged penis (HP:0000040)1.67767867
156Lymphangioma (HP:0100764)1.67746160
157Supernumerary spleens (HP:0009799)1.66819293
158Flat cornea (HP:0007720)1.65602388
159Supernumerary ribs (HP:0005815)1.64809519
160Missing ribs (HP:0000921)1.64549277
161Distal lower limb amyotrophy (HP:0008944)1.63731841
162Wrist flexion contracture (HP:0001239)1.63730213
163Aplasia/hypoplasia of the humerus (HP:0006507)1.63457133
164Thin bony cortex (HP:0002753)1.63345394
165Abnormality of the phalanges of the hallux (HP:0010057)1.62537520
166Malnutrition (HP:0004395)1.62051727
167Long toe (HP:0010511)1.62005457
168Lip pit (HP:0100267)1.61294192
169Micronodular cirrhosis (HP:0001413)1.61010548
170Chromosomal breakage induced by crosslinking agents (HP:0003221)1.60211714
171Pulmonary artery stenosis (HP:0004415)1.60000650
172Viral hepatitis (HP:0006562)1.59814958
173Entropion (HP:0000621)1.59418047
174Elbow flexion contracture (HP:0002987)1.57457894
175Turricephaly (HP:0000262)1.55962105
176Truncus arteriosus (HP:0001660)1.55850598
177Microretrognathia (HP:0000308)1.55793747

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K4.51838408
2TLK14.33172860
3TRIB34.01387575
4SMG13.42853403
5PKN22.97924265
6IRAK32.93757985
7SIK12.65452381
8TAOK12.61117543
9MOS2.39564457
10LATS22.29107380
11CDC72.25677780
12CAMK1D2.19951234
13MAP3K62.14214537
14MAPKAPK32.07126898
15CDK122.03052299
16MAP3K102.01185991
17KSR21.93047534
18RPS6KB21.91969345
19LATS11.84657252
20NEK21.82063467
21BRAF1.76278929
22KDR1.67720842
23NEK11.66650066
24PIM21.59913179
25RAF11.57218315
26BUB11.56279857
27TTK1.53686039
28SCYL21.53217234
29EPHB21.46959513
30MAP2K21.46902453
31PTK21.46844921
32TAOK21.46699454
33CDK71.46369619
34RIPK11.42006197
35WEE11.37117638
36MAP4K11.32704728
37ICK1.31414709
38BCKDK1.30695433
39ARAF1.30536583
40CAMK1G1.30495699
41CHEK21.29889135
42MST1R1.23855844
43MAP3K111.22895998
44TGFBR11.22865626
45TESK11.15492173
46CDK191.14506972
47PAK41.12094548
48PLK11.11339488
49SRPK11.11316017
50VRK21.11198317
51MAP3K91.10911678
52PRKD31.10748168
53CDK41.03863391
54TYRO31.02071119
55MAP4K21.00325348
56BMX0.99757950
57MAP3K80.98669716
58RPS6KA20.97897682
59MAPK150.96870501
60TIE10.95288337
61MTOR0.94987415
62LMTK20.94349856
63PIM10.94329072
64TTN0.94162886
65AURKA0.93682200
66TNK20.92295147
67KSR10.91877706
68FLT30.91874215
69CDK80.90424809
70RPS6KA40.88388061
71LIMK10.88356980
72NME20.88082137
73ERN10.88053089
74PRKD20.85386037
75AKT20.83249011
76PRPF4B0.82679526
77SIK20.81579668
78MAPKAPK50.80535817
79PRKCI0.79841729
80STK100.79395686
81MELK0.78995514
82PRKG20.78292886
83INSRR0.78118824
84RPS6KA60.77421549
85RPS6KL10.77379245
86RPS6KC10.77379245
87PAK60.77053328
88PAK20.74367564
89DAPK30.72584322
90KIT0.72540150
91DYRK1B0.71245250
92TGFBR20.70960068
93PLK40.70614286
94ATR0.70547038
95DDR20.70282798
96BMPR20.69720656
97MAP2K60.68962897
98CHEK10.67287659
99DYRK30.66674283
100MAPK120.66341203
101ILK0.64768659
102PDGFRA0.64677067
103MAP3K10.64373794
104NTRK10.63003618
105IKBKB0.61465646
106PTK60.60995412
107PASK0.60047613
108PRKAA10.57161972
109MAP3K130.55898028
110MARK20.55487859
111MAP2K30.55487197
112MATK0.54264783
113AURKB0.53895355
114PAK10.53507436
115TAOK30.52841747
116CDK20.52484582
117DAPK10.52197808
118ABL20.51816271
119LRRK20.50669097
120CDK90.50482704
121MAP3K30.50150893
122CSF1R0.48765307
123ALK0.47540587
124MAPK110.47353724
125CAMK40.46256514
126MAP3K70.44691539
127HIPK20.44233946
128TESK20.42155630
129CAMKK10.40187114
130EPHA20.39888151
131RPS6KA10.39575074
132RET0.39546582
133MAPK90.39452265
134ATM0.39322396
135CHUK0.38417235
136CSNK1G30.38205146
137MAPK130.36871288
138CAMK10.36688743
139PDPK10.36241912
140DYRK20.35354714
141TSSK60.35246719
142GRK50.35102721
143CDC42BPA0.34616505
144ADRBK20.34152203
145MAP3K140.33135965
146CDK11A0.30180687
147GRK60.29916195
148NME10.27679565

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.73702251
2Base excision repair_Homo sapiens_hsa034103.06345894
3Mismatch repair_Homo sapiens_hsa034303.00358220
4Glycosaminoglycan degradation_Homo sapiens_hsa005312.60461667
5Cell cycle_Homo sapiens_hsa041102.52484768
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.50861693
7RNA transport_Homo sapiens_hsa030132.46076061
8Spliceosome_Homo sapiens_hsa030402.34007617
9Nucleotide excision repair_Homo sapiens_hsa034202.24033893
10Other glycan degradation_Homo sapiens_hsa005112.23526133
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.17886942
12Thyroid cancer_Homo sapiens_hsa052162.14498511
13Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.11319903
14Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.07534437
15RNA degradation_Homo sapiens_hsa030181.97209929
16Homologous recombination_Homo sapiens_hsa034401.77439600
17Lysosome_Homo sapiens_hsa041421.74079041
18Notch signaling pathway_Homo sapiens_hsa043301.73075877
19Bladder cancer_Homo sapiens_hsa052191.68750624
20RNA polymerase_Homo sapiens_hsa030201.67249627
21mRNA surveillance pathway_Homo sapiens_hsa030151.63649518
22Oocyte meiosis_Homo sapiens_hsa041141.61946986
23Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.51943163
24Chronic myeloid leukemia_Homo sapiens_hsa052201.44368120
25Colorectal cancer_Homo sapiens_hsa052101.41993587
26Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.41293927
27Central carbon metabolism in cancer_Homo sapiens_hsa052301.41014830
28Non-small cell lung cancer_Homo sapiens_hsa052231.35219939
29Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.34779821
30Folate biosynthesis_Homo sapiens_hsa007901.33183696
31Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.32483553
32p53 signaling pathway_Homo sapiens_hsa041151.32347329
33Fanconi anemia pathway_Homo sapiens_hsa034601.25796976
34One carbon pool by folate_Homo sapiens_hsa006701.25541411
35Pyrimidine metabolism_Homo sapiens_hsa002401.24346149
36Ribosome_Homo sapiens_hsa030101.23056146
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.22484808
38VEGF signaling pathway_Homo sapiens_hsa043701.16337360
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.15055671
40Acute myeloid leukemia_Homo sapiens_hsa052211.12936695
41mTOR signaling pathway_Homo sapiens_hsa041501.09590370
42Endometrial cancer_Homo sapiens_hsa052131.09580247
43Axon guidance_Homo sapiens_hsa043601.08915818
44Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.08286246
45HTLV-I infection_Homo sapiens_hsa051661.08077350
46Thyroid hormone signaling pathway_Homo sapiens_hsa049191.05483053
47MicroRNAs in cancer_Homo sapiens_hsa052061.04848258
48Melanoma_Homo sapiens_hsa052181.04144558
49alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.03456202
50Biosynthesis of amino acids_Homo sapiens_hsa012301.01845150
51Focal adhesion_Homo sapiens_hsa045101.01190593
52Pancreatic cancer_Homo sapiens_hsa052120.99412190
53Neurotrophin signaling pathway_Homo sapiens_hsa047220.98668947
54Hippo signaling pathway_Homo sapiens_hsa043900.97270553
55TGF-beta signaling pathway_Homo sapiens_hsa043500.95212440
56Sulfur relay system_Homo sapiens_hsa041220.95055923
57ECM-receptor interaction_Homo sapiens_hsa045120.94899209
58Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.94000889
59Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.93573177
60Phospholipase D signaling pathway_Homo sapiens_hsa040720.93341165
61AMPK signaling pathway_Homo sapiens_hsa041520.91307080
62Small cell lung cancer_Homo sapiens_hsa052220.91193234
63Apoptosis_Homo sapiens_hsa042100.88432223
64Herpes simplex infection_Homo sapiens_hsa051680.87331193
65Viral carcinogenesis_Homo sapiens_hsa052030.87278385
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.86899768
67RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.85449792
68African trypanosomiasis_Homo sapiens_hsa051430.85036663
69Epstein-Barr virus infection_Homo sapiens_hsa051690.83888678
70Malaria_Homo sapiens_hsa051440.82932633
71Insulin signaling pathway_Homo sapiens_hsa049100.82852409
72Basal transcription factors_Homo sapiens_hsa030220.82279612
73Transcriptional misregulation in cancer_Homo sapiens_hsa052020.81992580
74Vitamin B6 metabolism_Homo sapiens_hsa007500.80963417
75B cell receptor signaling pathway_Homo sapiens_hsa046620.79602016
76Shigellosis_Homo sapiens_hsa051310.79326232
77HIF-1 signaling pathway_Homo sapiens_hsa040660.79036816
78GnRH signaling pathway_Homo sapiens_hsa049120.78570687
79Regulation of actin cytoskeleton_Homo sapiens_hsa048100.77222677
80Phototransduction_Homo sapiens_hsa047440.77071793
81Toll-like receptor signaling pathway_Homo sapiens_hsa046200.75567483
82Vibrio cholerae infection_Homo sapiens_hsa051100.75298693
83Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.74683920
84Non-homologous end-joining_Homo sapiens_hsa034500.74566205
85Salmonella infection_Homo sapiens_hsa051320.74069512
86Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.72144789
87Cyanoamino acid metabolism_Homo sapiens_hsa004600.71260051
88N-Glycan biosynthesis_Homo sapiens_hsa005100.70218910
89Fructose and mannose metabolism_Homo sapiens_hsa000510.70154793
90Glioma_Homo sapiens_hsa052140.67639893
91Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.67420872
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.67057954
93NF-kappa B signaling pathway_Homo sapiens_hsa040640.66646916
94Ras signaling pathway_Homo sapiens_hsa040140.66462878
95Cysteine and methionine metabolism_Homo sapiens_hsa002700.65768904
96Prolactin signaling pathway_Homo sapiens_hsa049170.65258467
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.64920221
98Adherens junction_Homo sapiens_hsa045200.64743108
99Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.64480233
100Purine metabolism_Homo sapiens_hsa002300.63931090
101Hepatitis B_Homo sapiens_hsa051610.63372697
102Basal cell carcinoma_Homo sapiens_hsa052170.63122182
103Pentose phosphate pathway_Homo sapiens_hsa000300.63067452
104Sphingolipid metabolism_Homo sapiens_hsa006000.62706919
105Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.61768641
106PI3K-Akt signaling pathway_Homo sapiens_hsa041510.61411715
107Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61323990
108Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60727060
109Wnt signaling pathway_Homo sapiens_hsa043100.60597385
110Hedgehog signaling pathway_Homo sapiens_hsa043400.59522390
111Hepatitis C_Homo sapiens_hsa051600.58667115
112Pathways in cancer_Homo sapiens_hsa052000.58318549
113Synaptic vesicle cycle_Homo sapiens_hsa047210.58247157
114Galactose metabolism_Homo sapiens_hsa000520.57861347
115Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57679778
116Amoebiasis_Homo sapiens_hsa051460.57195830
117Leishmaniasis_Homo sapiens_hsa051400.56746698
118Gap junction_Homo sapiens_hsa045400.55458820
119Platelet activation_Homo sapiens_hsa046110.55344858
120MAPK signaling pathway_Homo sapiens_hsa040100.55272029
121Choline metabolism in cancer_Homo sapiens_hsa052310.54386922
122Prion diseases_Homo sapiens_hsa050200.53572048
123Osteoclast differentiation_Homo sapiens_hsa043800.53051497
124Ovarian steroidogenesis_Homo sapiens_hsa049130.52893458
125TNF signaling pathway_Homo sapiens_hsa046680.52345476
126Proteoglycans in cancer_Homo sapiens_hsa052050.51254856
127Dilated cardiomyopathy_Homo sapiens_hsa054140.51141338
128Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50908415
129Insulin resistance_Homo sapiens_hsa049310.50838179
130Lysine degradation_Homo sapiens_hsa003100.50684261
131Dorso-ventral axis formation_Homo sapiens_hsa043200.50320252
132Aldosterone synthesis and secretion_Homo sapiens_hsa049250.49989436
133Glycerophospholipid metabolism_Homo sapiens_hsa005640.49667591
134Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49647801
135Estrogen signaling pathway_Homo sapiens_hsa049150.49471600
136Endocytosis_Homo sapiens_hsa041440.47234644
137Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47083132
138AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.46969596
139Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46764370
140Type II diabetes mellitus_Homo sapiens_hsa049300.46324918
141ErbB signaling pathway_Homo sapiens_hsa040120.43444433
142Olfactory transduction_Homo sapiens_hsa047400.40706596
143Prostate cancer_Homo sapiens_hsa052150.39996342
144Influenza A_Homo sapiens_hsa051640.39344641
145Rap1 signaling pathway_Homo sapiens_hsa040150.38376025
146Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38148288
147Selenocompound metabolism_Homo sapiens_hsa004500.36596202
148Oxytocin signaling pathway_Homo sapiens_hsa049210.34908322
149FoxO signaling pathway_Homo sapiens_hsa040680.34375464
150Tight junction_Homo sapiens_hsa045300.33786895

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