MIER1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that was first identified in Xenopus laevis by its role in a mesoderm induction early response (MIER). The encoded protein functions as a transcriptional regulator. Alternatively spliced transcript variants encode multiple isoforms, some of which lack a C-terminal nuclear localization signal. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.90126213
2regulation of gamma-delta T cell differentiation (GO:0045586)5.49984848
3regulation of gamma-delta T cell activation (GO:0046643)5.49877755
4positive regulation of natural killer cell differentiation (GO:0032825)5.00179394
5positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.89146379
6lactate metabolic process (GO:0006089)4.60477913
7DNA deamination (GO:0045006)4.52638504
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.46449049
9DNA double-strand break processing (GO:0000729)4.33335983
10negative T cell selection (GO:0043383)4.27769970
11signal peptide processing (GO:0006465)4.13796281
12protein K11-linked deubiquitination (GO:0035871)4.04762184
13prenylation (GO:0097354)4.02357537
14protein prenylation (GO:0018342)4.02357537
15platelet dense granule organization (GO:0060155)4.00276004
16V(D)J recombination (GO:0033151)3.98616225
17mucosal-associated lymphoid tissue development (GO:0048537)3.95885033
18Peyers patch development (GO:0048541)3.95885033
19positive regulation of protein autophosphorylation (GO:0031954)3.93429805
20negative regulation of erythrocyte differentiation (GO:0045647)3.91948514
21positive T cell selection (GO:0043368)3.85008440
22valine metabolic process (GO:0006573)3.79505534
23definitive hemopoiesis (GO:0060216)3.63514112
24positive regulation of B cell differentiation (GO:0045579)3.62918215
25response to pheromone (GO:0019236)3.62897846
26respiratory chain complex IV assembly (GO:0008535)3.59556934
27myoblast migration (GO:0051451)3.59075470
28antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.58947742
29antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.58947742
30antigen processing and presentation of endogenous antigen (GO:0019883)3.54455867
31water-soluble vitamin biosynthetic process (GO:0042364)3.52733727
32regulation of B cell differentiation (GO:0045577)3.45235553
33regulation of interleukin-2 biosynthetic process (GO:0045076)3.45118396
34RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.44010263
35interferon-gamma production (GO:0032609)3.42977331
36T cell selection (GO:0045058)3.41454634
37histone mRNA catabolic process (GO:0071044)3.41001186
38regulation of hexokinase activity (GO:1903299)3.40996764
39regulation of glucokinase activity (GO:0033131)3.40996764
40positive regulation of interleukin-2 production (GO:0032743)3.40738966
41regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.36928302
42negative regulation of DNA-dependent DNA replication (GO:2000104)3.35204565
43regulation of natural killer cell differentiation (GO:0032823)3.34214166
44negative thymic T cell selection (GO:0045060)3.30265354
45negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.26692590
46protein K6-linked ubiquitination (GO:0085020)3.25794624
47negative regulation of thymocyte apoptotic process (GO:0070244)3.25708875
48proteasome assembly (GO:0043248)3.25508573
49keratinocyte development (GO:0003334)3.25020208
50inositol phosphate catabolic process (GO:0071545)3.20935569
51alpha-beta T cell differentiation (GO:0046632)3.20531854
52positive regulation of DNA recombination (GO:0045911)3.18449705
53alpha-beta T cell activation (GO:0046631)3.16380211
54positive regulation of glycoprotein biosynthetic process (GO:0010560)3.13952514
55energy homeostasis (GO:0097009)3.13755094
56meiotic chromosome segregation (GO:0045132)3.13555609
57natural killer cell differentiation (GO:0001779)3.11446614
58T cell differentiation in thymus (GO:0033077)3.09934335
59T cell differentiation (GO:0030217)3.09097058
60regulation of chemokine biosynthetic process (GO:0045073)3.07987269
61regulation of type B pancreatic cell apoptotic process (GO:2000674)3.06742610
62regulation of meiosis I (GO:0060631)3.05355119
63somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.05159080
64somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.05159080
65isotype switching (GO:0045190)3.05159080
66B cell mediated immunity (GO:0019724)3.04195421
67UDP-N-acetylglucosamine metabolic process (GO:0006047)3.03647836
68T cell homeostasis (GO:0043029)3.03266512
69cytochrome complex assembly (GO:0017004)3.02702568
70positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.99890863
71T cell lineage commitment (GO:0002360)2.99207336
72inositol phosphate dephosphorylation (GO:0046855)2.97787897
73phosphorylated carbohydrate dephosphorylation (GO:0046838)2.97787897
74regulation of protein glycosylation (GO:0060049)2.97638803
75synapsis (GO:0007129)2.94387355
76positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.92384345
77CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.92034056
78regulation of B cell apoptotic process (GO:0002902)2.91574247
79positive regulation of mitotic sister chromatid separation (GO:1901970)2.90585845
80positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.90585845
81positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.90585845
82cytidine metabolic process (GO:0046087)2.89041444
83cytidine catabolic process (GO:0006216)2.89041444
84cytidine deamination (GO:0009972)2.89041444
85positive regulation of isotype switching (GO:0045830)2.87777622
86exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.86502723
87histone H3-K4 trimethylation (GO:0080182)2.85594868
88positive regulation of glycolytic process (GO:0045821)2.85573021
89L-fucose catabolic process (GO:0042355)2.85509694
90fucose catabolic process (GO:0019317)2.85509694
91L-fucose metabolic process (GO:0042354)2.85509694
92regulation of protein autophosphorylation (GO:0031952)2.84309918
93angiogenesis involved in wound healing (GO:0060055)2.80846316
94nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.80784666
95negative regulation of execution phase of apoptosis (GO:1900118)2.79062388
96polyol catabolic process (GO:0046174)2.78838638
97negative regulation of JUN kinase activity (GO:0043508)2.78164978
98negative regulation of neurological system process (GO:0031645)2.77557185
99positive regulation of interferon-alpha production (GO:0032727)2.75305897
100double-strand break repair via homologous recombination (GO:0000724)2.74962525
101parental behavior (GO:0060746)2.74118141
102recombinational repair (GO:0000725)2.73169407
103CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.71088172
104mitotic sister chromatid cohesion (GO:0007064)2.69291596
105hepatocyte apoptotic process (GO:0097284)2.68777640
106establishment of protein localization to Golgi (GO:0072600)2.68184734
107attachment of spindle microtubules to kinetochore (GO:0008608)2.67430099
108CD4-positive, alpha-beta T cell activation (GO:0035710)2.66890333
109positive regulation of natural killer cell mediated immunity (GO:0002717)2.66145916
110positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.66145916
111activated T cell proliferation (GO:0050798)2.65313849
112regulation of alpha-beta T cell proliferation (GO:0046640)2.64158072
113regulation of interferon-alpha production (GO:0032647)2.64148253
114kidney morphogenesis (GO:0060993)2.64052135
115T-helper cell differentiation (GO:0042093)2.64033350
116CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.64033350
117protein targeting to Golgi (GO:0000042)2.63940369
118negative regulation of translation, ncRNA-mediated (GO:0040033)2.63749675
119regulation of translation, ncRNA-mediated (GO:0045974)2.63749675
120negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.63749675
121regulation of B cell receptor signaling pathway (GO:0050855)2.63148094
122negative regulation of myeloid cell apoptotic process (GO:0033033)2.62862190
123response to type I interferon (GO:0034340)2.61921527
124adaptation of signaling pathway (GO:0023058)2.60367677
125natural killer cell activation (GO:0030101)2.60123941
126myeloid dendritic cell activation (GO:0001773)2.58603265
127regulation of DNA endoreduplication (GO:0032875)2.56923725
128positive regulation of histone H3-K4 methylation (GO:0051571)2.56647674
129poly(A)+ mRNA export from nucleus (GO:0016973)2.54898112
130lymphocyte homeostasis (GO:0002260)2.54619067
131regulation of interleukin-12 biosynthetic process (GO:0045075)2.54260466
132positive regulation of macrophage differentiation (GO:0045651)2.54255828
133T cell activation (GO:0042110)2.54088545
134histone mRNA metabolic process (GO:0008334)2.53236260
135positive thymic T cell selection (GO:0045059)2.52255874
136maturation of 5.8S rRNA (GO:0000460)2.52214725
137regulation of thymocyte apoptotic process (GO:0070243)2.51691506
138type I interferon signaling pathway (GO:0060337)2.51440738
139cellular response to type I interferon (GO:0071357)2.51440738
140prostate gland growth (GO:0060736)2.51244676
141peptidyl-histidine modification (GO:0018202)2.51104079
142positive regulation of alpha-beta T cell proliferation (GO:0046641)2.50458181
143positive regulation of mRNA metabolic process (GO:1903313)2.50271256
144positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.49055550
145regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.49055550
146positive regulation of interferon-beta production (GO:0032728)2.48379182
147regulation of erythrocyte differentiation (GO:0045646)2.48142659
148cellular ketone body metabolic process (GO:0046950)2.45814189
149regulation of Rac protein signal transduction (GO:0035020)2.45648972
150neutrophil activation (GO:0042119)2.45542832
151negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.45526822
152monoubiquitinated protein deubiquitination (GO:0035520)2.45432488
153regulation of T cell receptor signaling pathway (GO:0050856)2.45426271
154mast cell activation (GO:0045576)2.45270593
155negative regulation of B cell activation (GO:0050869)2.44860624
156lymphocyte differentiation (GO:0030098)2.44853099
157positive regulation of mRNA processing (GO:0050685)2.44686769
158dendritic cell chemotaxis (GO:0002407)2.44647739
159DNA catabolic process, exonucleolytic (GO:0000738)2.44347225
160negative regulation of acute inflammatory response (GO:0002674)2.44242939
161positive regulation of granulocyte differentiation (GO:0030854)2.43930389
162pyrimidine ribonucleoside catabolic process (GO:0046133)2.42734998
163histone H3-K4 methylation (GO:0051568)2.39653355
164regulation of natural killer cell mediated immunity (GO:0002715)2.39578168
165regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.39578168
166positive regulation of mRNA catabolic process (GO:0061014)2.38641430
167regulation of interleukin-2 production (GO:0032663)2.38142250
168negative regulation of protein autophosphorylation (GO:0031953)2.37838496
169JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.37728084
170negative regulation of phagocytosis (GO:0050765)2.37450540
171regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.36703703
172nuclear pore complex assembly (GO:0051292)2.36508355
173regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.36260658
174rRNA methylation (GO:0031167)2.36108368
175replication fork processing (GO:0031297)2.36071710
176positive regulation of activated T cell proliferation (GO:0042104)2.35783176
177positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.35640132
178neural tube formation (GO:0001841)2.35466768
179retrograde transport, vesicle recycling within Golgi (GO:0000301)2.35354901
180thymic T cell selection (GO:0045061)2.35221814
181dopamine transport (GO:0015872)2.34975926
182response to muramyl dipeptide (GO:0032495)2.34294913
183T cell activation involved in immune response (GO:0002286)2.34206448
184regulation of mRNA 3-end processing (GO:0031440)2.33489718
185histone H2A acetylation (GO:0043968)2.33444563
186regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.33342030
187positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.33342030
188positive regulation of B cell mediated immunity (GO:0002714)2.33285721
189positive regulation of immunoglobulin mediated immune response (GO:0002891)2.33285721
190negative regulation of viral genome replication (GO:0045071)2.33240295
191intestinal epithelial cell development (GO:0060576)2.33212377
192regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.31751434
193rRNA catabolic process (GO:0016075)2.30378042
194protein K63-linked deubiquitination (GO:0070536)2.29922775
195somatic diversification of immunoglobulins (GO:0016445)2.29348636
196histamine secretion (GO:0001821)2.29035760

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.97734677
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.88114025
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.27908707
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.48886872
5GATA1_22025678_ChIP-Seq_K562_Human4.27284256
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.53706299
7EGR1_19374776_ChIP-ChIP_THP-1_Human3.48877826
8STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.40223414
9BP1_19119308_ChIP-ChIP_Hs578T_Human3.35420536
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.88448341
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.78073541
12RUNX_20019798_ChIP-Seq_JUKART_Human2.71718413
13SCL_19346495_ChIP-Seq_HPC-7_Human2.70942614
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.43997428
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.43130517
16SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.41521733
17* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.33972861
18MYB_26560356_Chip-Seq_TH2_Human2.32150600
19KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.31858832
20VDR_22108803_ChIP-Seq_LS180_Human2.28406026
21STAT4_19710469_ChIP-ChIP_TH1__Mouse2.25426933
22IRF8_27001747_Chip-Seq_BMDM_Mouse2.23267801
23ZFP57_27257070_Chip-Seq_ESCs_Mouse2.19952898
24ZNF274_21170338_ChIP-Seq_K562_Hela2.13321627
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.09030232
26FUS_26573619_Chip-Seq_HEK293_Human2.08882004
27P300_19829295_ChIP-Seq_ESCs_Human2.08251123
28GABP_17652178_ChIP-ChIP_JURKAT_Human2.08165909
29NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.07879452
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.05730393
31GBX2_23144817_ChIP-Seq_PC3_Human1.96282354
32SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.94047063
33MYB_26560356_Chip-Seq_TH1_Human1.93913811
34AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.92159203
35TAF15_26573619_Chip-Seq_HEK293_Human1.91978964
36E2F4_17652178_ChIP-ChIP_JURKAT_Human1.88030535
37EST1_17652178_ChIP-ChIP_JURKAT_Human1.87375607
38SMAD_19615063_ChIP-ChIP_OVARY_Human1.82675130
39FOXM1_23109430_ChIP-Seq_U2OS_Human1.78817616
40FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.77235247
41RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.76267034
42GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.75766529
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.72106883
44MYB_21317192_ChIP-Seq_ERMYB_Mouse1.67508058
45ELK1_19687146_ChIP-ChIP_HELA_Human1.66731934
46IGF1R_20145208_ChIP-Seq_DFB_Human1.64681035
47Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.63908483
48SALL1_21062744_ChIP-ChIP_HESCs_Human1.62604947
49GATA2_21666600_ChIP-Seq_HMVEC_Human1.60694486
50VDR_23849224_ChIP-Seq_CD4+_Human1.60573414
51ER_23166858_ChIP-Seq_MCF-7_Human1.60085470
52MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.58173266
53BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.56925854
54E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.55809137
55STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.55447420
56ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.54529863
57PADI4_21655091_ChIP-ChIP_MCF-7_Human1.54015401
58RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.53183610
59HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.52735259
60STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.52693808
61CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.47931724
62* SPI1_23547873_ChIP-Seq_NB4_Human1.47410880
63SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45851005
64FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.45023065
65NANOG_18555785_Chip-Seq_ESCs_Mouse1.42912139
66MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.42062111
67SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.41867178
68PIAS1_25552417_ChIP-Seq_VCAP_Human1.40908831
69BCAT_22108803_ChIP-Seq_LS180_Human1.40557909
70* MAF_26560356_Chip-Seq_TH1_Human1.40323328
71PU_27001747_Chip-Seq_BMDM_Mouse1.40009276
72CRX_20693478_ChIP-Seq_RETINA_Mouse1.39754542
73TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.36020034
74OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35602377
75CDX2_22108803_ChIP-Seq_LS180_Human1.35587414
76CTBP2_25329375_ChIP-Seq_LNCAP_Human1.35525379
77SMAD4_21799915_ChIP-Seq_A2780_Human1.34005186
78RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.33469801
79NANOG_19829295_ChIP-Seq_ESCs_Human1.32176378
80SOX2_19829295_ChIP-Seq_ESCs_Human1.32176378
81CBP_20019798_ChIP-Seq_JUKART_Human1.31809929
82IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.31809929
83GATA3_27048872_Chip-Seq_THYMUS_Human1.30927730
84P53_22387025_ChIP-Seq_ESCs_Mouse1.30552076
85EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.29861542
86* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.29674975
87UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.29304510
88TP63_19390658_ChIP-ChIP_HaCaT_Human1.27334095
89* STAT3_23295773_ChIP-Seq_U87_Human1.25512808
90SUZ12_18555785_Chip-Seq_ESCs_Mouse1.24866828
91RUNX1_22412390_ChIP-Seq_EML_Mouse1.24247515
92E2F1_18555785_Chip-Seq_ESCs_Mouse1.23990131
93CMYC_18555785_Chip-Seq_ESCs_Mouse1.23806629
94BRD4_27068464_Chip-Seq_AML-cells_Mouse1.23771204
95* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.23726719
96FOXM1_26456572_ChIP-Seq_MCF-7_Human1.23591715
97EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.22895626
98OCT4_21477851_ChIP-Seq_ESCs_Mouse1.22806235
99SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.20330088
100* P300_18555785_Chip-Seq_ESCs_Mouse1.19675694
101E2F1_21310950_ChIP-Seq_MCF-7_Human1.17602041
102HOXB4_20404135_ChIP-ChIP_EML_Mouse1.17532767
103CTBP1_25329375_ChIP-Seq_LNCAP_Human1.17512436
104STAT3_18555785_Chip-Seq_ESCs_Mouse1.16549535
105SMAD3_21741376_ChIP-Seq_EPCs_Human1.15931032
106AR_25329375_ChIP-Seq_VCAP_Human1.15751496
107EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.14834949
108* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.14413176
109SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13964253
110* TCF4_22108803_ChIP-Seq_LS180_Human1.13940275
111MYC_22102868_ChIP-Seq_BL_Human1.13905264
112FOXA1_21572438_ChIP-Seq_LNCaP_Human1.11549816
113TCF4_23295773_ChIP-Seq_U87_Human1.11340201
114CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.11254144
115SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.11100678
116SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.11100678
117GATA2_22383799_ChIP-Seq_G1ME_Mouse1.10796738
118VDR_24787735_ChIP-Seq_THP-1_Human1.10636281
119* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.10009207
120SOX2_18555785_Chip-Seq_ESCs_Mouse1.09844048
121FOXP3_21729870_ChIP-Seq_TREG_Human1.09435470
122UTX_26944678_Chip-Seq_JUKART_Human1.09269395
123* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.09079135
124NOTCH1_21737748_ChIP-Seq_TLL_Human1.08552240
125* TCF7_22412390_ChIP-Seq_EML_Mouse1.08520292
126CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07784856
127EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.07721808
128ELF1_17652178_ChIP-ChIP_JURKAT_Human1.07543326
129TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07234485
130FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.06886306
131* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.06879718
132TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.06835372
133FOXA1_27270436_Chip-Seq_PROSTATE_Human1.06368650
134FOXA1_25329375_ChIP-Seq_VCAP_Human1.06368650
135FLI1_21867929_ChIP-Seq_TH2_Mouse1.06239065
136OCT4_18555785_Chip-Seq_ESCs_Mouse1.05902963
137MYC_18940864_ChIP-ChIP_HL60_Human1.04925526
138SALL4_22934838_ChIP-ChIP_CD34+_Human1.04783088
139FLI1_27457419_Chip-Seq_LIVER_Mouse1.04322509
140RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.02657439
141PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98181727
142* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.96468254
143TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.96409518
144EGR1_23403033_ChIP-Seq_LIVER_Mouse0.96298769
145* VDR_24763502_ChIP-Seq_THP-1_Human0.95815094
146CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.94559514
147* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.93000980
148EZH2_27294783_Chip-Seq_NPCs_Mouse0.92513164
149* GATA3_26560356_Chip-Seq_TH2_Human0.91697933
150MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.90608875
151LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.88845014
152PCGF2_27294783_Chip-Seq_ESCs_Mouse0.88569690
153WT1_19549856_ChIP-ChIP_CCG9911_Human0.87254613
154EWS_26573619_Chip-Seq_HEK293_Human0.86812779
155LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.86757567
156SPI1_23127762_ChIP-Seq_K562_Human0.85741651
157SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.84884705
158ESR1_21235772_ChIP-Seq_MCF-7_Human0.83277946
159* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.78937171
160PCGF2_27294783_Chip-Seq_NPCs_Mouse0.78819482
161PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.78238169
162NFE2_27457419_Chip-Seq_LIVER_Mouse0.77897399
163ETS1_22383799_ChIP-Seq_G1ME_Mouse0.74930078
164* VDR_21846776_ChIP-Seq_THP-1_Human0.74796375
165IRF1_19129219_ChIP-ChIP_H3396_Human0.74729771
166* BRD4_25478319_ChIP-Seq_HGPS_Human0.73832746
167* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.73612636
168SUZ12_27294783_Chip-Seq_NPCs_Mouse0.71075053
169GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.68951676
170FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.68584617
171TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.68468241

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis4.48015666
2MP0001835_abnormal_antigen_presentation3.40634757
3MP0008877_abnormal_DNA_methylation3.23682787
4MP0002132_abnormal_respiratory_system2.89387407
5MP0002166_altered_tumor_susceptibility2.87864199
6MP0002837_dystrophic_cardiac_calcinosis2.86317996
7MP0003763_abnormal_thymus_physiology2.65846584
8MP0005671_abnormal_response_to2.61217491
9MP0002006_tumorigenesis2.54324350
10MP0002009_preneoplasia2.37763015
11MP0010155_abnormal_intestine_physiology2.33468774
12MP0009785_altered_susceptibility_to2.33146988
13MP0001790_abnormal_immune_system2.26189441
14MP0005387_immune_system_phenotype2.26189441
15MP0002102_abnormal_ear_morphology2.23028384
16MP0010234_abnormal_vibrissa_follicle2.22729407
17MP0005379_endocrine/exocrine_gland_phen2.19027069
18MP0004808_abnormal_hematopoietic_stem2.15455926
19MP0002254_reproductive_system_inflammat2.12949378
20MP0001800_abnormal_humoral_immune2.10996279
21MP0002148_abnormal_hypersensitivity_rea2.08188650
22MP0005000_abnormal_immune_tolerance1.98556039
23MP0000685_abnormal_immune_system1.97933125
24MP0002405_respiratory_system_inflammati1.93036183
25MP0002452_abnormal_antigen_presenting1.93002305
26MP0001853_heart_inflammation1.91515608
27MP0006072_abnormal_retinal_apoptosis1.91077981
28MP0000703_abnormal_thymus_morphology1.90838201
29MP0002398_abnormal_bone_marrow1.90728391
30MP0005084_abnormal_gallbladder_morpholo1.89939351
31MP0001819_abnormal_immune_cell1.84442145
32MP0002396_abnormal_hematopoietic_system1.84135338
33MP0000372_irregular_coat_pigmentation1.83860712
34MP0002420_abnormal_adaptive_immunity1.82308083
35MP0002723_abnormal_immune_serum1.81539511
36MP0005025_abnormal_response_to1.81287333
37MP0005075_abnormal_melanosome_morpholog1.80626965
38MP0003724_increased_susceptibility_to1.75705053
39MP0004947_skin_inflammation1.73205908
40MP0009333_abnormal_splenocyte_physiolog1.72690319
41MP0000427_abnormal_hair_cycle1.71543104
42MP0001879_abnormal_lymphatic_vessel1.69135694
43MP0003300_gastrointestinal_ulcer1.64731148
44MP0003436_decreased_susceptibility_to1.63534836
45MP0005397_hematopoietic_system_phenotyp1.63281148
46MP0001545_abnormal_hematopoietic_system1.63281148
47MP0002419_abnormal_innate_immunity1.62955754
48MP0000716_abnormal_immune_system1.62568153
49MP0008057_abnormal_DNA_replication1.62288089
50MP0002722_abnormal_immune_system1.59962827
51MP0002877_abnormal_melanocyte_morpholog1.59765904
52MP0000516_abnormal_urinary_system1.59156851
53MP0005367_renal/urinary_system_phenotyp1.59156851
54MP0000689_abnormal_spleen_morphology1.58941531
55MP0005409_darkened_coat_color1.58493476
56MP0006082_CNS_inflammation1.57895225
57MP0003252_abnormal_bile_duct1.55849760
58MP0005220_abnormal_exocrine_pancreas1.55643867
59MP0010094_abnormal_chromosome_stability1.54621265
60MP0000015_abnormal_ear_pigmentation1.52278521
61MP0010678_abnormal_skin_adnexa1.44194015
62MP0002928_abnormal_bile_duct1.41593082
63MP0009278_abnormal_bone_marrow1.41562569
64MP0002429_abnormal_blood_cell1.37415564
65MP0001845_abnormal_inflammatory_respons1.35796394
66MP0002693_abnormal_pancreas_physiology1.34044203
67MP0010352_gastrointestinal_tract_polyps1.32765258
68MP0005253_abnormal_eye_physiology1.32308017
69MP0008058_abnormal_DNA_repair1.32085042
70MP0008872_abnormal_physiological_respon1.30432753
71MP0005389_reproductive_system_phenotype1.30057501
72MP0003943_abnormal_hepatobiliary_system1.28589677
73MP0008007_abnormal_cellular_replicative1.26123792
74MP0005551_abnormal_eye_electrophysiolog1.25088642
75MP0002938_white_spotting1.24389345
76MP0005174_abnormal_tail_pigmentation1.23166330
77MP0005464_abnormal_platelet_physiology1.22414674
78MP0002876_abnormal_thyroid_physiology1.22409690
79MP0003828_pulmonary_edema1.22298292
80MP0009764_decreased_sensitivity_to1.18278539
81MP0003718_maternal_effect1.17246380
82MP0000490_abnormal_crypts_of1.14888223
83MP0003950_abnormal_plasma_membrane1.14821052
84MP0002095_abnormal_skin_pigmentation1.14517661
85MP0006054_spinal_hemorrhage1.14252851
86MP0009697_abnormal_copulation1.12195846
87MP0006036_abnormal_mitochondrial_physio1.11741648
88MP0004215_abnormal_myocardial_fiber1.11386245
89MP0003787_abnormal_imprinting1.11330228
90MP0002933_joint_inflammation1.11167918
91MP0002168_other_aberrant_phenotype1.08289066
92MP0000465_gastrointestinal_hemorrhage1.08151218
93MP0001873_stomach_inflammation1.08004695
94MP0005395_other_phenotype1.07689349
95MP0005310_abnormal_salivary_gland1.07523058
96MP0003045_fibrosis1.06505578
97MP0001944_abnormal_pancreas_morphology1.05884333
98MP0003186_abnormal_redox_activity1.05302651
99MP0003890_abnormal_embryonic-extraembry1.04920860
100MP0001915_intracranial_hemorrhage1.03606550
101MP0005408_hypopigmentation1.03523189
102MP0003121_genomic_imprinting1.03238981
103MP0003806_abnormal_nucleotide_metabolis1.03176078
104MP0005332_abnormal_amino_acid1.02355832
105MP0003283_abnormal_digestive_organ1.02122823
106MP0000767_abnormal_smooth_muscle1.00254159
107MP0002160_abnormal_reproductive_system0.96926739
108MP0000383_abnormal_hair_follicle0.95734746
109MP0002998_abnormal_bone_remodeling0.94826647
110MP0002019_abnormal_tumor_incidence0.94069379
111MP0005645_abnormal_hypothalamus_physiol0.93455781
112MP0001764_abnormal_homeostasis0.92685809
113MP0000569_abnormal_digit_pigmentation0.91695899
114MP0003448_altered_tumor_morphology0.91066091
115MP0003077_abnormal_cell_cycle0.90570589
116MP0004381_abnormal_hair_follicle0.90437322
117MP0010307_abnormal_tumor_latency0.89214601
118MP0005646_abnormal_pituitary_gland0.88453801
119MP0002163_abnormal_gland_morphology0.87591907
120MP0000613_abnormal_salivary_gland0.87413920
121MP0009780_abnormal_chondrocyte_physiolo0.86583681
122MP0003866_abnormal_defecation0.86470444
123MP0008995_early_reproductive_senescence0.85292767
124MP0002138_abnormal_hepatobiliary_system0.84633306
125MP0002090_abnormal_vision0.82426026
126MP0000858_altered_metastatic_potential0.80799552
127MP0005647_abnormal_sex_gland0.80113209
128MP0003566_abnormal_cell_adhesion0.79928149
129MP0008875_abnormal_xenobiotic_pharmacok0.79253739
130MP0010368_abnormal_lymphatic_system0.79031022
131MP0001984_abnormal_olfaction0.78304532
132MP0001533_abnormal_skeleton_physiology0.78283260
133MP0001485_abnormal_pinna_reflex0.77416038
134MP0001929_abnormal_gametogenesis0.77286431
135MP0004957_abnormal_blastocyst_morpholog0.77161519
136MP0005636_abnormal_mineral_homeostasis0.77112488
137MP0001919_abnormal_reproductive_system0.76821610
138MP0004510_myositis0.76321667
139MP0008469_abnormal_protein_level0.76311988
140MP0005076_abnormal_cell_differentiation0.74986700
141MP0001986_abnormal_taste_sensitivity0.74377253
142MP0001191_abnormal_skin_condition0.74130544
143MP0001119_abnormal_female_reproductive0.73641495
144MP0003279_aneurysm0.73631003
145MP0004484_altered_response_of0.72770080
146MP0003693_abnormal_embryo_hatching0.72246702
147MP0001243_abnormal_dermal_layer0.72106157
148MP0009765_abnormal_xenobiotic_induced0.71598572
149MP0004043_abnormal_pH_regulation0.71250359
150MP0000653_abnormal_sex_gland0.71060736
151MP0002098_abnormal_vibrissa_morphology0.70139388
152MP0001849_ear_inflammation0.69793853
153MP0000627_abnormal_mammary_gland0.69447482
154MP0001756_abnormal_urination0.69221824
155MP0001188_hyperpigmentation0.68743945
156MP0002277_abnormal_respiratory_mucosa0.68350184
157MP0004147_increased_porphyrin_level0.65498746
158MP0003786_premature_aging0.65089555
159MP0003111_abnormal_nucleus_morphology0.64582979

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)5.33426887
2Abnormality of T cell number (HP:0011839)5.27896894
3Abnormality of B cell number (HP:0010975)4.81120581
4B lymphocytopenia (HP:0010976)4.81120581
5Thyroiditis (HP:0100646)4.66465756
6Hypoplasia of the thymus (HP:0000778)4.43486213
7Recurrent viral infections (HP:0004429)4.14703603
8Severe combined immunodeficiency (HP:0004430)3.94100217
9Panhypogammaglobulinemia (HP:0003139)3.91975346
10Eosinophilia (HP:0001880)3.81951833
11Hypothermia (HP:0002045)3.51062143
12Combined immunodeficiency (HP:0005387)3.45461547
13Abnormality of the fingertips (HP:0001211)3.43375222
14Recurrent fungal infections (HP:0002841)3.29990294
15Granulocytopenia (HP:0001913)3.28820978
16Abnormality of T cells (HP:0002843)3.18637774
17Methylmalonic acidemia (HP:0002912)3.10555361
18Stomatitis (HP:0010280)3.06441736
19Pancreatic cysts (HP:0001737)3.06049245
20Hypoglycemic seizures (HP:0002173)3.03254097
21Abnormality of eosinophils (HP:0001879)3.01455227
22Autoimmune thrombocytopenia (HP:0001973)2.97826244
23Recurrent abscess formation (HP:0002722)2.95822462
24Hyperinsulinemic hypoglycemia (HP:0000825)2.95312507
25Abnormal hair whorl (HP:0010721)2.91088785
26Neoplasm of the adrenal cortex (HP:0100641)2.89144395
27Optic neuritis (HP:0100653)2.86796369
28Retrobulbar optic neuritis (HP:0100654)2.86796369
29Pancreatic islet-cell hyperplasia (HP:0004510)2.82705609
30Intestinal atresia (HP:0011100)2.82305114
31Syringomyelia (HP:0003396)2.81404301
32Spinal cord lesions (HP:0100561)2.81404301
33Hypoglycemic coma (HP:0001325)2.80582037
34Hypoproteinemia (HP:0003075)2.80149757
35Abnormality of the pancreatic islet cells (HP:0006476)2.76039266
36Abnormality of endocrine pancreas physiology (HP:0012093)2.76039266
37Meningioma (HP:0002858)2.75094566
38Pancreatic fibrosis (HP:0100732)2.71236652
39Myositis (HP:0100614)2.70992968
40Abnormality of the renal cortex (HP:0011035)2.68543969
41Acute myeloid leukemia (HP:0004808)2.63927576
42Hematochezia (HP:0002573)2.63241613
43Volvulus (HP:0002580)2.61807757
44Orchitis (HP:0100796)2.61590745
45Abnormality of vitamin B metabolism (HP:0004340)2.59518639
46Leukocytosis (HP:0001974)2.58359545
47Meningitis (HP:0001287)2.56518132
48IgM deficiency (HP:0002850)2.52623123
49Conjunctival hamartoma (HP:0100780)2.52552804
50IgG deficiency (HP:0004315)2.52416011
51Prostate neoplasm (HP:0100787)2.50278572
52Abnormality of chromosome stability (HP:0003220)2.49598410
53Eczematoid dermatitis (HP:0000976)2.47681325
54Periodontitis (HP:0000704)2.46540402
55Aqueductal stenosis (HP:0002410)2.43272084
56Abnormality of aspartate family amino acid metabolism (HP:0010899)2.43070518
57Deep philtrum (HP:0002002)2.43006061
58Urethral obstruction (HP:0000796)2.42776875
59Petechiae (HP:0000967)2.42709473
60Abnormality of methionine metabolism (HP:0010901)2.40569582
61Pustule (HP:0200039)2.39035530
62True hermaphroditism (HP:0010459)2.39016816
63Neoplasm of the adrenal gland (HP:0100631)2.36471962
64IgA deficiency (HP:0002720)2.35468974
65Mediastinal lymphadenopathy (HP:0100721)2.34558635
66Hyperglycemia (HP:0003074)2.34339122
67Lip pit (HP:0100267)2.34250363
68Recurrent bacterial skin infections (HP:0005406)2.33950930
69Progressive macrocephaly (HP:0004481)2.33824916
70Chronic diarrhea (HP:0002028)2.33602183
71Keratoconjunctivitis sicca (HP:0001097)2.33329589
72Ketoacidosis (HP:0001993)2.30974851
73Methylmalonic aciduria (HP:0012120)2.30626290
74Molar tooth sign on MRI (HP:0002419)2.30223107
75Abnormality of midbrain morphology (HP:0002418)2.30223107
76Recurrent bronchitis (HP:0002837)2.29746665
77Hamartoma of the eye (HP:0010568)2.29656265
78Prolonged bleeding time (HP:0003010)2.22297223
79White forelock (HP:0002211)2.21567890
80Abnormal delayed hypersensitivity skin test (HP:0002963)2.19682549
81Abnormal rod and cone electroretinograms (HP:0008323)2.18857569
82Neoplasm of the tracheobronchial system (HP:0100552)2.17106964
83Alveolar cell carcinoma (HP:0006519)2.16206254
84Lymphoma (HP:0002665)2.16194384
85Abnormality of the vitamin B12 metabolism (HP:0004341)2.15357041
86Medial flaring of the eyebrow (HP:0010747)2.14975775
87Aplasia/Hypoplasia of the fovea (HP:0008060)2.13802990
88Hypoplasia of the fovea (HP:0007750)2.13802990
89Abnormal platelet volume (HP:0011876)2.13254130
90Vasculitis (HP:0002633)2.12019803
91Large for gestational age (HP:0001520)2.11511345
92Keratoconjunctivitis (HP:0001096)2.08862496
93Absent frontal sinuses (HP:0002688)2.08541705
94Fair hair (HP:0002286)2.07862965
95Congenital stationary night blindness (HP:0007642)2.07427952
96Symptomatic seizures (HP:0011145)2.06185781
97Increased hepatocellular lipid droplets (HP:0006565)2.05283144
98Albinism (HP:0001022)2.04888045
99Abnormal pancreas size (HP:0012094)2.04638217
100Furrowed tongue (HP:0000221)2.04190590
101Abnormality of the prostate (HP:0008775)2.03705029
102Stomach cancer (HP:0012126)2.03049542
103Chromsome breakage (HP:0040012)2.01281836
104Spontaneous hematomas (HP:0007420)2.01119528
105Arterial thrombosis (HP:0004420)2.00337251
106Breast carcinoma (HP:0003002)2.00168584
107Nephronophthisis (HP:0000090)1.99712095
108Abnormality of the pons (HP:0007361)1.99266943
109Gingival bleeding (HP:0000225)1.98963415
110Short 5th finger (HP:0009237)1.98600440
111Chronic otitis media (HP:0000389)1.97702541
112Cellulitis (HP:0100658)1.97286101
113Increased CSF lactate (HP:0002490)1.97146842
114Abnormality of the nasal septum (HP:0000419)1.96171515
115Encephalitis (HP:0002383)1.95764919
116Short middle phalanx of the 5th finger (HP:0004220)1.94195501
117Gingivitis (HP:0000230)1.93771363
118Attenuation of retinal blood vessels (HP:0007843)1.93743559
119Patchy hypopigmentation of hair (HP:0011365)1.93211729
120Lipid accumulation in hepatocytes (HP:0006561)1.93053930
121Increased IgM level (HP:0003496)1.92097263
122Abnormality of the renal medulla (HP:0100957)1.92040021
123Agammaglobulinemia (HP:0004432)1.91774069
124Abolished electroretinogram (ERG) (HP:0000550)1.91301410
125Truncal obesity (HP:0001956)1.90381166
126Subacute progressive viral hepatitis (HP:0006572)1.90123866
127Clubbing of toes (HP:0100760)1.89604306
128Chromosomal breakage induced by crosslinking agents (HP:0003221)1.89204525
129Long eyelashes (HP:0000527)1.87612590
130Sensory axonal neuropathy (HP:0003390)1.87462800
131Abnormal biliary tract morphology (HP:0012440)1.87297996
132Hypomagnesemia (HP:0002917)1.87107456
133Amaurosis fugax (HP:0100576)1.86409169
134Gaze-evoked nystagmus (HP:0000640)1.86252164
135Sepsis (HP:0100806)1.85368549
136Joint swelling (HP:0001386)1.85164272
137Aplasia/Hypoplasia of the uvula (HP:0010293)1.84949382
138Long clavicles (HP:0000890)1.83026827
139Abnormality of the fovea (HP:0000493)1.82822379
140Inflammation of the large intestine (HP:0002037)1.82566922
141Glycosuria (HP:0003076)1.82559905
142Abnormality of urine glucose concentration (HP:0011016)1.82559905
143Abnormality of the preputium (HP:0100587)1.79989981
144Keratitis (HP:0000491)1.79763363
145Abnormality of the ileum (HP:0001549)1.79197284
146Ectopic kidney (HP:0000086)1.79133503
147Abnormality of the labia minora (HP:0012880)1.78585323
148Pulmonary infiltrates (HP:0002113)1.78013257
149Colitis (HP:0002583)1.77449874
150Elevated erythrocyte sedimentation rate (HP:0003565)1.77308999
151Mitochondrial inheritance (HP:0001427)1.76380646
152Meckel diverticulum (HP:0002245)1.75943299
153Tongue fasciculations (HP:0001308)1.75664334
154Exertional dyspnea (HP:0002875)1.75340602
155Disproportionate short-trunk short stature (HP:0003521)1.74469400
156Cutaneous melanoma (HP:0012056)1.74305988
157Papillary thyroid carcinoma (HP:0002895)1.74007438
158Autoimmune hemolytic anemia (HP:0001890)1.73281206
159Increased mean platelet volume (HP:0011877)1.72767658
160Type I transferrin isoform profile (HP:0003642)1.72183798
161Lymphopenia (HP:0001888)1.71975269
162Epistaxis (HP:0000421)1.71824726
163Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.71518215
164Renal cortical cysts (HP:0000803)1.71516455
165Abnormality of the frontal sinuses (HP:0002687)1.70859169
166Hypochromic microcytic anemia (HP:0004840)1.70763542
167Acute necrotizing encephalopathy (HP:0006965)1.70727130
168Glomerulopathy (HP:0100820)1.70617677
169Generalized hypopigmentation of hair (HP:0011358)1.70445983
170Metaphyseal dysplasia (HP:0100255)1.70041251
171Hepatic necrosis (HP:0002605)1.69461266
172Acute lymphatic leukemia (HP:0006721)1.69414760
173Abnormality of cells of the lymphoid lineage (HP:0012140)1.68733226
174Aplasia/Hypoplasia of the tongue (HP:0010295)1.68121812
175Rhabdomyosarcoma (HP:0002859)1.68044200
176Thyroid carcinoma (HP:0002890)1.67188764
177Gastrointestinal inflammation (HP:0004386)1.66970559
178Sloping forehead (HP:0000340)1.66314167
179Myelodysplasia (HP:0002863)1.65525674
180Biliary tract neoplasm (HP:0100574)1.64786129
181Dyschromatopsia (HP:0007641)1.64307374
182Congenital sensorineural hearing impairment (HP:0008527)1.64032911
183Abnormality of vitamin metabolism (HP:0100508)1.63213137
184Abnormality of renal resorption (HP:0011038)1.62960794
185Progressive inability to walk (HP:0002505)1.62814218
186Tubular atrophy (HP:0000092)1.62424535
187Absent thumb (HP:0009777)1.61232702
188Prominent metopic ridge (HP:0005487)1.61179653
189Hypoplasia of the pons (HP:0012110)1.59538849
1903-Methylglutaconic aciduria (HP:0003535)1.59430017
191Male pseudohermaphroditism (HP:0000037)1.58649168

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.39425637
2JAK33.38963282
3EIF2AK33.33146656
4MAP3K143.25705468
5MKNK23.10247122
6TRIM283.04447869
7ZAK2.72599565
8BMPR1B2.54166879
9MKNK12.43179069
10TNIK2.39214424
11MAP4K12.36383841
12NUAK12.23588394
13MAP4K22.15910032
14WNK32.06317153
15FGFR22.03981511
16EIF2AK12.03585112
17BTK1.99222730
18TEC1.85796269
19IKBKE1.82194533
20TYK21.77983070
21PLK31.72104147
22PLK21.67653943
23YES11.66453521
24BRSK21.65847168
25MST41.64102568
26IKBKB1.63131784
27INSRR1.62392172
28SYK1.62283274
29IRAK41.57617618
30CHUK1.57465022
31PIM11.56008736
32ITK1.53923732
33ERBB31.50199533
34STK41.49924560
35STK391.48190699
36FRK1.48101883
37OXSR11.46550948
38FGFR31.41083215
39CDK121.35308982
40ZAP701.34392056
41JAK11.33777332
42BUB11.33475753
43IRAK31.32538398
44TRPM71.31703301
45BMPR21.28785055
46MST1R1.25431433
47CLK11.24436887
48BCR1.19699684
49SGK21.18104692
50STK38L1.17955283
51NLK1.14886756
52PAK31.09810008
53FER1.06313476
54PBK1.06030176
55LCK1.05574814
56SGK31.04275621
57PIK3CA1.04075207
58ADRBK21.03936514
59CSNK1A1L1.03583593
60STK241.02646753
61NME21.00866187
62STK100.98399211
63MAP3K120.96439663
64NEK90.94748711
65NEK60.91999255
66TIE10.91026088
67PLK40.91010860
68MAPK70.89802730
69TGFBR10.89085664
70CDK60.88970250
71SRPK10.88406627
72CSK0.87608814
73HCK0.86439557
74BRD40.85532798
75LYN0.85165921
76MARK30.82051784
77PRKCE0.81795728
78TBK10.81288665
79AKT30.80927364
80WEE10.79260424
81KIT0.79141324
82JAK20.78860775
83ATR0.78726310
84RPS6KB10.76984369
85HIPK20.75156018
86MAP3K30.73757767
87STK30.73331907
88PDK20.73266435
89IRAK10.72872412
90TAF10.72791118
91CSF1R0.70823955
92TGFBR20.69549708
93MAP3K20.68853368
94ACVR1B0.68525108
95VRK10.68211817
96PIK3CG0.67568662
97TSSK60.67299104
98BMX0.67296967
99MAPK130.64678775
100NEK10.63609312
101ATM0.62604777
102RPS6KA40.62549588
103CDK90.62251972
104PTK2B0.61972042
105MAP2K30.61750110
106PDGFRB0.61732218
107MELK0.61386175
108PRKCQ0.60937263
109EPHA30.60420240
110EIF2AK20.60092348
111STK160.59569447
112CDK30.58300511
113RPS6KB20.57981789
114TNK20.56783837
115PASK0.56324499
116FGFR40.55338806
117FLT30.55321213
118RPS6KA60.55204181
119MAP3K40.52793599
120RPS6KL10.52682022
121RPS6KC10.52682022
122CASK0.50540264
123PNCK0.49727175
124SIK30.48532947
125FGFR10.47551835
126PLK10.47365846
127CHEK20.47327888
128MAPK30.46431826
129ABL10.45649509
130WNK40.42976557
131RIPK10.42414486
132MAP3K100.42033925
133GRK10.41498571
134TTK0.40145761
135CSNK1G10.39438501
136IGF1R0.38989843
137ADRBK10.36939409
138CAMKK20.35871581
139TAOK30.35656270
140GRK60.35315222
141MAPK40.35256219
142CDC70.35228126
143CSNK1G20.31204201
144PRKCI0.30556230
145PRKD30.25159021
146MAP2K60.25032130
147DAPK20.24770050
148VRK20.24651491
149CSNK1G30.23695990
150PINK10.23200173
151PRKAA20.22561798
152EGFR0.21715105

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030604.59581112
2Primary immunodeficiency_Homo sapiens_hsa053403.74918200
3Maturity onset diabetes of the young_Homo sapiens_hsa049503.52024394
4Proteasome_Homo sapiens_hsa030503.18387475
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.75029503
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.55792661
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.46426140
8Measles_Homo sapiens_hsa051622.33684451
9Propanoate metabolism_Homo sapiens_hsa006402.31348107
10Graft-versus-host disease_Homo sapiens_hsa053322.29994901
11Non-homologous end-joining_Homo sapiens_hsa034502.27631871
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.23560367
13Allograft rejection_Homo sapiens_hsa053302.18981781
14Hematopoietic cell lineage_Homo sapiens_hsa046402.10936210
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.06607581
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.04224735
17Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.99267779
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.97465984
19Antigen processing and presentation_Homo sapiens_hsa046121.94728000
20Leishmaniasis_Homo sapiens_hsa051401.91970181
21Nitrogen metabolism_Homo sapiens_hsa009101.88703047
22Butanoate metabolism_Homo sapiens_hsa006501.87532211
23RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.83249084
24T cell receptor signaling pathway_Homo sapiens_hsa046601.80420775
25Herpes simplex infection_Homo sapiens_hsa051681.80211725
26Autoimmune thyroid disease_Homo sapiens_hsa053201.69730935
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.67396725
28Toll-like receptor signaling pathway_Homo sapiens_hsa046201.61714332
29Selenocompound metabolism_Homo sapiens_hsa004501.58828139
30Influenza A_Homo sapiens_hsa051641.53299017
31Jak-STAT signaling pathway_Homo sapiens_hsa046301.52303680
32Osteoclast differentiation_Homo sapiens_hsa043801.52167345
33Vitamin B6 metabolism_Homo sapiens_hsa007501.51559717
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.48708822
35Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.48064242
36Legionellosis_Homo sapiens_hsa051341.44670036
37Transcriptional misregulation in cancer_Homo sapiens_hsa052021.43240961
38Regulation of autophagy_Homo sapiens_hsa041401.41527856
39Pentose and glucuronate interconversions_Homo sapiens_hsa000401.39634237
40Hepatitis B_Homo sapiens_hsa051611.38332712
41TNF signaling pathway_Homo sapiens_hsa046681.34167566
42Phototransduction_Homo sapiens_hsa047441.32125681
43Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.31663790
44B cell receptor signaling pathway_Homo sapiens_hsa046621.30324383
45Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.30151120
46Malaria_Homo sapiens_hsa051441.28782028
47Acute myeloid leukemia_Homo sapiens_hsa052211.28498477
48Caffeine metabolism_Homo sapiens_hsa002321.27437423
49Tryptophan metabolism_Homo sapiens_hsa003801.25594939
50RNA polymerase_Homo sapiens_hsa030201.24830096
51Leukocyte transendothelial migration_Homo sapiens_hsa046701.24056503
52Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.23302352
53Peroxisome_Homo sapiens_hsa041461.20284776
54Ether lipid metabolism_Homo sapiens_hsa005651.14994645
55Circadian rhythm_Homo sapiens_hsa047101.12531423
56RNA transport_Homo sapiens_hsa030131.11589219
57Adherens junction_Homo sapiens_hsa045201.11421953
58Toxoplasmosis_Homo sapiens_hsa051451.10520899
59Mismatch repair_Homo sapiens_hsa034301.09048829
60Staphylococcus aureus infection_Homo sapiens_hsa051501.08853298
61African trypanosomiasis_Homo sapiens_hsa051431.06591840
62Collecting duct acid secretion_Homo sapiens_hsa049661.06554553
63HTLV-I infection_Homo sapiens_hsa051661.06415497
64Oxidative phosphorylation_Homo sapiens_hsa001901.05233633
65Chronic myeloid leukemia_Homo sapiens_hsa052201.05051002
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.04982952
67AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.03125253
68Apoptosis_Homo sapiens_hsa042101.02518945
69Fanconi anemia pathway_Homo sapiens_hsa034601.02407308
70Pertussis_Homo sapiens_hsa051331.01555041
71Linoleic acid metabolism_Homo sapiens_hsa005911.00559921
72Fatty acid elongation_Homo sapiens_hsa000620.99157708
73p53 signaling pathway_Homo sapiens_hsa041150.97287127
74Dorso-ventral axis formation_Homo sapiens_hsa043200.95403877
75Viral myocarditis_Homo sapiens_hsa054160.94122512
76DNA replication_Homo sapiens_hsa030300.93170525
77Asthma_Homo sapiens_hsa053100.92573263
78Base excision repair_Homo sapiens_hsa034100.92406677
79Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.92368924
80Type I diabetes mellitus_Homo sapiens_hsa049400.90848446
81MicroRNAs in cancer_Homo sapiens_hsa052060.87506564
82Primary bile acid biosynthesis_Homo sapiens_hsa001200.86869402
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.86818629
84Chemokine signaling pathway_Homo sapiens_hsa040620.85780974
85alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.85502110
86Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.84089506
87FoxO signaling pathway_Homo sapiens_hsa040680.84012840
88Tuberculosis_Homo sapiens_hsa051520.84003639
89Salmonella infection_Homo sapiens_hsa051320.83615545
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.83376553
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.82366914
92Prolactin signaling pathway_Homo sapiens_hsa049170.81147823
93Shigellosis_Homo sapiens_hsa051310.80893381
94Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.80819639
95Viral carcinogenesis_Homo sapiens_hsa052030.80651604
96Prostate cancer_Homo sapiens_hsa052150.80393399
97RNA degradation_Homo sapiens_hsa030180.80289596
98Homologous recombination_Homo sapiens_hsa034400.80251399
99Cell cycle_Homo sapiens_hsa041100.79860412
100Small cell lung cancer_Homo sapiens_hsa052220.79634586
101Systemic lupus erythematosus_Homo sapiens_hsa053220.79353263
102Lysine degradation_Homo sapiens_hsa003100.75238709
103Hepatitis C_Homo sapiens_hsa051600.74632834
104Thyroid cancer_Homo sapiens_hsa052160.73990127
105Oocyte meiosis_Homo sapiens_hsa041140.70566122
106Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.69368656
107Non-small cell lung cancer_Homo sapiens_hsa052230.68608099
108Purine metabolism_Homo sapiens_hsa002300.66319595
109SNARE interactions in vesicular transport_Homo sapiens_hsa041300.65745329
110Basal transcription factors_Homo sapiens_hsa030220.65209618
111One carbon pool by folate_Homo sapiens_hsa006700.65055987
112Fatty acid degradation_Homo sapiens_hsa000710.64038616
113beta-Alanine metabolism_Homo sapiens_hsa004100.64021282
114Retinol metabolism_Homo sapiens_hsa008300.63899335
115Platelet activation_Homo sapiens_hsa046110.62641626
116Steroid hormone biosynthesis_Homo sapiens_hsa001400.62258342
117Steroid biosynthesis_Homo sapiens_hsa001000.61963070
118Epstein-Barr virus infection_Homo sapiens_hsa051690.61887910
119Chemical carcinogenesis_Homo sapiens_hsa052040.61518828
120Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.60230761
121Parkinsons disease_Homo sapiens_hsa050120.60220392
122Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58001235
123Rheumatoid arthritis_Homo sapiens_hsa053230.57541354
124TGF-beta signaling pathway_Homo sapiens_hsa043500.55885987
125Drug metabolism - other enzymes_Homo sapiens_hsa009830.55757212
126Notch signaling pathway_Homo sapiens_hsa043300.54820067
127Mineral absorption_Homo sapiens_hsa049780.53821465
128Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53051634
129Nucleotide excision repair_Homo sapiens_hsa034200.52108060
130Spliceosome_Homo sapiens_hsa030400.51629565
131Pathways in cancer_Homo sapiens_hsa052000.50124086
132mRNA surveillance pathway_Homo sapiens_hsa030150.49925953
133N-Glycan biosynthesis_Homo sapiens_hsa005100.49618336
134Glutathione metabolism_Homo sapiens_hsa004800.48936238
135Insulin secretion_Homo sapiens_hsa049110.48234015
136ABC transporters_Homo sapiens_hsa020100.47371421
137Proteoglycans in cancer_Homo sapiens_hsa052050.47365443
138Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.46586838
139Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.46533429
140Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.45920856
141Other glycan degradation_Homo sapiens_hsa005110.45112971
142Sphingolipid metabolism_Homo sapiens_hsa006000.45047804
143Starch and sucrose metabolism_Homo sapiens_hsa005000.45047629
144Endometrial cancer_Homo sapiens_hsa052130.44235681
145Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43375658
146Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.42691968
147Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42472930
148Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.42397564
149Metabolic pathways_Homo sapiens_hsa011000.41557039
150Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41438445
151Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39278420
152Sulfur metabolism_Homo sapiens_hsa009200.38236206
153Fatty acid metabolism_Homo sapiens_hsa012120.37983337
154Glycerolipid metabolism_Homo sapiens_hsa005610.36804878
155Cysteine and methionine metabolism_Homo sapiens_hsa002700.35563107
156Arachidonic acid metabolism_Homo sapiens_hsa005900.33954618
157Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.30936582

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