MID2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to microtubular structures in the cytoplasm. Alternate splicing of this gene results in two transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)4.44254782
2COPI coating of Golgi vesicle (GO:0048205)4.44254782
3regulation of water loss via skin (GO:0033561)4.29483573
4keratinization (GO:0031424)4.17469337
5establishment of skin barrier (GO:0061436)4.02097314
6skin morphogenesis (GO:0043589)3.95489108
7protein localization to endosome (GO:0036010)3.54892915
8cell-substrate junction assembly (GO:0007044)3.48268715
9COPII vesicle coating (GO:0048208)3.45911073
10negative regulation of fatty acid transport (GO:2000192)3.35364926
11actin-myosin filament sliding (GO:0033275)3.30325985
12muscle filament sliding (GO:0030049)3.30325985
13cell adhesion mediated by integrin (GO:0033627)3.29209907
14vocalization behavior (GO:0071625)3.29013598
15retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.12756134
16synaptic vesicle maturation (GO:0016188)3.12035339
17epithelial cell-cell adhesion (GO:0090136)3.11283684
18regulation of short-term neuronal synaptic plasticity (GO:0048172)3.07833666
19cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.07440452
20adherens junction assembly (GO:0034333)3.06715693
21regulation of transforming growth factor beta1 production (GO:0032908)3.06017246
22skeletal muscle adaptation (GO:0043501)3.05001439
23regulation of transforming growth factor beta2 production (GO:0032909)3.04402342
24actin-mediated cell contraction (GO:0070252)3.02477389
25cell-substrate adherens junction assembly (GO:0007045)3.02340283
26focal adhesion assembly (GO:0048041)3.02340283
27retina vasculature morphogenesis in camera-type eye (GO:0061299)3.01839890
28locomotory exploration behavior (GO:0035641)2.99002862
29regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.95921609
30wound healing, spreading of epidermal cells (GO:0035313)2.94069456
31vesicle coating (GO:0006901)2.93970926
32carnitine shuttle (GO:0006853)2.91132612
33multicellular organismal water homeostasis (GO:0050891)2.90523937
34regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.90021930
35layer formation in cerebral cortex (GO:0021819)2.89602820
36proline transport (GO:0015824)2.89181792
37cell communication involved in cardiac conduction (GO:0086065)2.88699604
38cell communication by electrical coupling (GO:0010644)2.83623592
39actin filament-based movement (GO:0030048)2.82311657
40response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.78137786
41vascular endothelial growth factor signaling pathway (GO:0038084)2.77683013
42sarcomere organization (GO:0045214)2.77515422
43chondrocyte development (GO:0002063)2.76384905
44activation of protein kinase A activity (GO:0034199)2.75677579
45positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.71739013
46glutamate secretion (GO:0014047)2.70774498
47sarcoplasmic reticulum calcium ion transport (GO:0070296)2.67551514
48regulation of cardioblast differentiation (GO:0051890)2.66766123
49regulation of synaptic vesicle exocytosis (GO:2000300)2.65362101
50synaptic vesicle docking involved in exocytosis (GO:0016081)2.62584482
51dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.62457020
52glomerular basement membrane development (GO:0032836)2.62172312
53synaptic vesicle exocytosis (GO:0016079)2.62055234
54chemical homeostasis within a tissue (GO:0048875)2.61999688
55macroautophagy (GO:0016236)2.61933864
56skeletal muscle contraction (GO:0003009)2.60517352
57endoplasmic reticulum organization (GO:0007029)2.55863417
58positive regulation of blood vessel endothelial cell migration (GO:0043536)2.55118989
59myoblast fusion (GO:0007520)2.53917825
60detection of calcium ion (GO:0005513)2.53396821
61positive regulation of keratinocyte differentiation (GO:0045618)2.53345146
62surfactant homeostasis (GO:0043129)2.51310513
63NADH metabolic process (GO:0006734)2.50461006
64desmosome organization (GO:0002934)2.50395941
65substrate-dependent cell migration (GO:0006929)2.49895349
66endocrine hormone secretion (GO:0060986)2.49840402
67regulation of heart rate by cardiac conduction (GO:0086091)2.49744684
68neurotransmitter secretion (GO:0007269)2.49236418
69regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.48555598
70peptide cross-linking (GO:0018149)2.48067294
71cardiac conduction (GO:0061337)2.47194961
72positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.47109219
73keratinocyte differentiation (GO:0030216)2.46929457
74intestinal epithelial cell development (GO:0060576)2.46478067
75membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.44772530
76membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.41230661
77regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.41160731
78striated muscle atrophy (GO:0014891)2.41103996
79neurotransmitter-gated ion channel clustering (GO:0072578)2.41047363
80actomyosin structure organization (GO:0031032)2.40930189
81syncytium formation by plasma membrane fusion (GO:0000768)2.40280392
82vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.39870335
83hippo signaling (GO:0035329)2.39328867
84membrane repolarization during action potential (GO:0086011)2.38539890
85regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.37425650
86lymph vessel development (GO:0001945)2.36969216
87protein localization to cell surface (GO:0034394)2.36654167
88regulation of glutamate receptor signaling pathway (GO:1900449)2.36365402
89response to muscle activity (GO:0014850)2.35537900
90regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.35210556
91gap junction assembly (GO:0016264)2.34723701
92positive regulation of cardiac muscle hypertrophy (GO:0010613)2.34481392
93positive regulation of muscle hypertrophy (GO:0014742)2.34481392
94plasma membrane repair (GO:0001778)2.33668955
95sodium ion export (GO:0071436)2.32256752
96regulation of cholesterol homeostasis (GO:2000188)2.32240257
97embryonic eye morphogenesis (GO:0048048)2.32143329
98regulation of synapse structural plasticity (GO:0051823)2.31954738
99epithelial cell differentiation involved in prostate gland development (GO:0060742)2.31577203
100water homeostasis (GO:0030104)2.31349785
101bundle of His cell to Purkinje myocyte communication (GO:0086069)2.29498279
102wound healing, spreading of cells (GO:0044319)2.28448463
103negative regulation of cell size (GO:0045792)2.28363523
104hypotonic response (GO:0006971)2.27955918
105dendrite morphogenesis (GO:0048813)2.27041307
106gamma-aminobutyric acid transport (GO:0015812)2.26502448
107positive regulation of epidermal cell differentiation (GO:0045606)2.26015483
108myofibril assembly (GO:0030239)2.25005603
109peptidyl-proline hydroxylation (GO:0019511)2.24789581
110hemidesmosome assembly (GO:0031581)2.24458573
111basement membrane organization (GO:0071711)2.24380245
112endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.23911835
113regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.22758599
114protein hydroxylation (GO:0018126)2.22038786
115ear development (GO:0043583)2.22032431
116relaxation of cardiac muscle (GO:0055119)2.21952771
117insulin-like growth factor receptor signaling pathway (GO:0048009)2.21802927
118regulation of synaptic vesicle transport (GO:1902803)2.21247087
119cellular potassium ion homeostasis (GO:0030007)2.20417919
120negative regulation of keratinocyte proliferation (GO:0010839)2.20303962
121linoleic acid metabolic process (GO:0043651)2.20276937
122carnitine transmembrane transport (GO:1902603)2.20205403
123regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.19311691
124regulation of fatty acid beta-oxidation (GO:0031998)2.19239326
125keratinocyte proliferation (GO:0043616)2.19227853
126amyloid precursor protein metabolic process (GO:0042982)2.18802923
127maternal placenta development (GO:0001893)2.18631850
128membrane repolarization (GO:0086009)2.18492320
129cytoskeletal anchoring at plasma membrane (GO:0007016)2.18464530
130negative regulation of skeletal muscle tissue development (GO:0048642)2.18017365
131regulation of axon extension involved in axon guidance (GO:0048841)2.17359145
132neuron recognition (GO:0008038)2.16720899
133ventricular cardiac muscle cell action potential (GO:0086005)2.16673973
134biotin metabolic process (GO:0006768)2.16641114
135fatty acid transmembrane transport (GO:1902001)2.16382185
136regulation of membrane repolarization (GO:0060306)2.16225544
137regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.16196835
138negative regulation of vascular permeability (GO:0043116)2.15597473
139positive regulation of cellular response to insulin stimulus (GO:1900078)2.15157602
140glycine transport (GO:0015816)2.14815017
141exploration behavior (GO:0035640)2.14451738
142axonal fasciculation (GO:0007413)2.14368627
143semaphorin-plexin signaling pathway (GO:0071526)2.14366157
144positive regulation of p38MAPK cascade (GO:1900745)2.14268114
145alanine transport (GO:0032328)2.14189511
146cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.13039281
147adherens junction organization (GO:0034332)2.12868866
148positive regulation of potassium ion transport (GO:0043268)2.12229921
149regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.11694681
150potassium ion import (GO:0010107)2.10591117
151regulation of long-term neuronal synaptic plasticity (GO:0048169)2.08407575
152cochlea development (GO:0090102)2.08350900
153protein localization to synapse (GO:0035418)2.07978119
154multicellular organismal signaling (GO:0035637)2.07973702
155cerebellar Purkinje cell differentiation (GO:0021702)2.06534502
156innervation (GO:0060384)2.04546049
157regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.03917399
158potassium ion homeostasis (GO:0055075)2.03866656
159positive regulation of potassium ion transmembrane transport (GO:1901381)2.03314187
160neuron cell-cell adhesion (GO:0007158)2.03288098
161positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.03182693
162peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.02756709
163regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.02165306
164protein targeting to Golgi (GO:0000042)2.01983466
165auditory behavior (GO:0031223)2.00954097
166regulation of neuronal synaptic plasticity (GO:0048168)2.00709074
167positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)1.99311893
168regulation of cAMP-dependent protein kinase activity (GO:2000479)1.99295676
169membrane assembly (GO:0071709)1.99295672
170cardiac muscle cell action potential (GO:0086001)1.99248279
171axon extension (GO:0048675)1.98761803
172regulation of inhibitory postsynaptic membrane potential (GO:0060080)1.97899329
173establishment of nucleus localization (GO:0040023)1.97641240
174neurotransmitter transport (GO:0006836)1.96629661
175regulation of axon guidance (GO:1902667)1.96538650
176positive regulation of synaptic transmission, glutamatergic (GO:0051968)1.96291129
177cardiac muscle cell action potential involved in contraction (GO:0086002)1.95421513
178dendritic spine morphogenesis (GO:0060997)1.94045351
179regulation of cardioblast proliferation (GO:0003264)1.93470391
180regulation of secondary heart field cardioblast proliferation (GO:0003266)1.93470391
181mating behavior (GO:0007617)1.93321108
182membrane depolarization during action potential (GO:0086010)1.92935963
183lymphangiogenesis (GO:0001946)1.92592764
184vesicle transport along microtubule (GO:0047496)1.92550110
185cellular response to vitamin D (GO:0071305)1.92266207
186regulation of potassium ion transmembrane transport (GO:1901379)1.91215633
187neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)1.91119552
188negative regulation of synaptic transmission, glutamatergic (GO:0051967)1.89941964
189regulation of synaptic transmission, glutamatergic (GO:0051966)1.89804093
190positive regulation of synaptic transmission, GABAergic (GO:0032230)1.89577858
191regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)1.89102044
192sequestering of extracellular ligand from receptor (GO:0035581)1.88365867

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.77278150
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.04471054
3EZH2_22144423_ChIP-Seq_EOC_Human2.90193195
4GBX2_23144817_ChIP-Seq_PC3_Human2.69150080
5SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.56894655
6RARG_19884340_ChIP-ChIP_MEFs_Mouse2.54224359
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.53647461
8CLOCK_20551151_ChIP-Seq_293T_Human2.45467962
9* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.40951188
10HIF1A_21447827_ChIP-Seq_MCF-7_Human2.31356150
11TRIM28_21343339_ChIP-Seq_HEK293_Human2.27784750
12* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.24237062
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.21709257
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.21709257
15TP63_17297297_ChIP-ChIP_HaCaT_Human2.20245857
16KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.18906841
17ZNF263_19887448_ChIP-Seq_K562_Human2.18558028
18JARID2_20064375_ChIP-Seq_MESCs_Mouse2.16720164
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.14633289
20SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.11878530
21SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.11878530
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.11796960
23EED_16625203_ChIP-ChIP_MESCs_Mouse2.09900505
24TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.07181995
25MTF2_20144788_ChIP-Seq_MESCs_Mouse2.02829288
26JARID2_20075857_ChIP-Seq_MESCs_Mouse2.02086577
27* EZH2_27304074_Chip-Seq_ESCs_Mouse1.96906413
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.95344261
29RACK7_27058665_Chip-Seq_MCF-7_Human1.95167092
30SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.93134389
31SMAD_19615063_ChIP-ChIP_OVARY_Human1.87640433
32TBX20_22080862_ChIP-Seq_HEART_Mouse1.86536730
33TBX20_22328084_ChIP-Seq_HEART_Mouse1.86536730
34ZNF217_24962896_ChIP-Seq_MCF-7_Human1.85141434
35CDX2_19796622_ChIP-Seq_MESCs_Mouse1.79060153
36CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.75942883
37PPAR_26484153_Chip-Seq_NCI-H1993_Human1.74982103
38DROSHA_22980978_ChIP-Seq_HELA_Human1.74919979
39KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.73348717
40* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.71817558
41* RNF2_27304074_Chip-Seq_ESCs_Mouse1.68798537
42SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.67415624
43PIAS1_25552417_ChIP-Seq_VCAP_Human1.66582045
44* EZH2_27294783_Chip-Seq_ESCs_Mouse1.65283663
45EP300_21415370_ChIP-Seq_HL-1_Mouse1.64712518
46PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.63627836
47AR_21572438_ChIP-Seq_LNCaP_Human1.62745940
48RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.62318668
49P300_27058665_Chip-Seq_ZR-75-30cells_Human1.62287615
50SUZ12_27294783_Chip-Seq_ESCs_Mouse1.60044372
51FOXO3_23340844_ChIP-Seq_DLD1_Human1.58995305
52SMAD4_21799915_ChIP-Seq_A2780_Human1.58158568
53PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.56922187
54ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.56561992
55BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.52192704
56ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.49876577
57TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.49505803
58GATA3_24758297_ChIP-Seq_MCF-7_Human1.49061243
59ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.48811118
60PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.48338137
61AHR_22903824_ChIP-Seq_MCF-7_Human1.46079799
62RUNX1_27514584_Chip-Seq_MCF-7_Human1.45072541
63P63_26484246_Chip-Seq_KERATINOCYTES_Human1.44258858
64CTBP2_25329375_ChIP-Seq_LNCAP_Human1.42779173
65ELK3_25401928_ChIP-Seq_HUVEC_Human1.42442534
66AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.41421442
67CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.40182376
68SOX2_27498859_Chip-Seq_STOMACH_Mouse1.40066814
69ARNT_22903824_ChIP-Seq_MCF-7_Human1.38966972
70SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33422690
71PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.32276359
72ATF3_27146783_Chip-Seq_COLON_Human1.31005019
73NR3C1_23031785_ChIP-Seq_PC12_Mouse1.30709941
74TP53_18474530_ChIP-ChIP_U2OS_Human1.29177460
75BCAT_22108803_ChIP-Seq_LS180_Human1.28516949
76ESR1_20079471_ChIP-ChIP_T-47D_Human1.27994106
77RXR_22158963_ChIP-Seq_LIVER_Mouse1.27272725
78SOX2_20726797_ChIP-Seq_SW620_Human1.26628719
79SOX2_21211035_ChIP-Seq_LN229_Gbm1.26480137
80RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.26468794
81PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.25809868
82P300_19829295_ChIP-Seq_ESCs_Human1.24623749
83* UBF1/2_26484160_Chip-Seq_HMECs_Human1.24521034
84FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.23874430
85SMAD3_21741376_ChIP-Seq_EPCs_Human1.23807489
86REST_21632747_ChIP-Seq_MESCs_Mouse1.23523324
87SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.23387018
88THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.22257886
89STAT3_23295773_ChIP-Seq_U87_Human1.20884388
90TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20474316
91WT1_25993318_ChIP-Seq_PODOCYTE_Human1.20270934
92CTBP1_25329375_ChIP-Seq_LNCAP_Human1.20192800
93* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20064306
94SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18773176
95BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.18682199
96TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.18422702
97AR_25329375_ChIP-Seq_VCAP_Human1.17787844
98TP53_16413492_ChIP-PET_HCT116_Human1.17409050
99ZFP57_27257070_Chip-Seq_ESCs_Mouse1.16787364
100KDM2B_26808549_Chip-Seq_K562_Human1.16617678
101NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.15988844
102NRF2_20460467_ChIP-Seq_MEFs_Mouse1.15988844
103ESR2_21235772_ChIP-Seq_MCF-7_Human1.15852131
104TAF15_26573619_Chip-Seq_HEK293_Human1.15825417
105ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.14972553
106TCF4_18268006_ChIP-ChIP_LS174T_Human1.13732437
107NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13155471
108CHD1_26751641_Chip-Seq_LNCaP_Human1.12702477
109FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.09915174
110RARB_27405468_Chip-Seq_BRAIN_Mouse1.09862785
111POU3F2_20337985_ChIP-ChIP_501MEL_Human1.09400531
112STAT6_21828071_ChIP-Seq_BEAS2B_Human1.09358462
113CJUN_26792858_Chip-Seq_BT549_Human1.09238826
114CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.08582841
115RXR_22108803_ChIP-Seq_LS180_Human1.07928962
116BRD4_25478319_ChIP-Seq_HGPS_Human1.07345797
117ESR1_15608294_ChIP-ChIP_MCF-7_Human1.07064255
118CBX2_27304074_Chip-Seq_ESCs_Mouse1.06882761
119RING1B_27294783_Chip-Seq_ESCs_Mouse1.06595496
120SMAD4_21741376_ChIP-Seq_HESCs_Human1.06305235
121NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.06267197
122BMI1_23680149_ChIP-Seq_NPCS_Mouse1.06170374
123ESR1_21235772_ChIP-Seq_MCF-7_Human1.05740267
124NFIB_24661679_ChIP-Seq_LUNG_Mouse1.05373130
125ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.05370508
126FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.05011799
127GATA6_25053715_ChIP-Seq_YYC3_Human1.04729230
128ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03856545
129WT1_19549856_ChIP-ChIP_CCG9911_Human1.03684698
130* AR_19668381_ChIP-Seq_PC3_Human1.02903214
131DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.02251221
132FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.02159298
133TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.01642917
134Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.01546868
135ZNF274_21170338_ChIP-Seq_K562_Hela1.01035337
136SMAD3_21741376_ChIP-Seq_HESCs_Human1.00544618
137TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00165796
138IGF1R_20145208_ChIP-Seq_DFB_Human1.00082383
139YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98601286
140SOX9_24532713_ChIP-Seq_HFSC_Mouse0.98505262
141TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97942959
142ERG_21242973_ChIP-ChIP_JURKAT_Human0.97928749
143FOXA2_19822575_ChIP-Seq_HepG2_Human0.97906407
144PPARA_22158963_ChIP-Seq_LIVER_Mouse0.97310109
145ISL1_27105846_Chip-Seq_CPCs_Mouse0.96581037
146KDM2B_26808549_Chip-Seq_SUP-B15_Human0.96265382
147TCF4_23295773_ChIP-Seq_U87_Human0.96149019
148RUNX2_22187159_ChIP-Seq_PCA_Human0.96088692
149PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95917435
150WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.95852983
151LXR_22158963_ChIP-Seq_LIVER_Mouse0.95598628
152UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94856682
153TP63_23658742_ChIP-Seq_EP156T_Human0.94474002
154NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.94056318
155EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.93906757
156BP1_19119308_ChIP-ChIP_Hs578T_Human0.93623581
157EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.93489383
158SALL4_18804426_ChIP-ChIP_XEN_Mouse0.92749009
159CTNNB1_20460455_ChIP-Seq_HCT116_Human0.92175923
160* RING1B_27294783_Chip-Seq_NPCs_Mouse0.91928943
161TCF4_22108803_ChIP-Seq_LS180_Human0.91720592
162ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91173281
163KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.90422277
164TCF7_22412390_ChIP-Seq_EML_Mouse0.90143012
165MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.89065975
166REST_18959480_ChIP-ChIP_MESCs_Mouse0.88682711
167EGR1_19374776_ChIP-ChIP_THP-1_Human0.88340249
168CDX2_20551321_ChIP-Seq_CACO-2_Human0.87680481
169FOXM1_26456572_ChIP-Seq_MCF-7_Human0.87593917
170GATA2_21666600_ChIP-Seq_HMVEC_Human0.86266028
171UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.86132366
172KLF5_25053715_ChIP-Seq_YYC3_Human0.85437120
173SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.85216507

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009780_abnormal_chondrocyte_physiolo3.68271388
2MP0004859_abnormal_synaptic_plasticity2.72583805
3MP0004233_abnormal_muscle_weight2.70295523
4MP0003566_abnormal_cell_adhesion2.66032943
5MP0004272_abnormal_basement_membrane2.59963089
6MP0010234_abnormal_vibrissa_follicle2.37173727
7MP0000013_abnormal_adipose_tissue2.29043129
8MP0005451_abnormal_body_composition2.24367331
9MP0010352_gastrointestinal_tract_polyps2.09740450
10MP0004185_abnormal_adipocyte_glucose1.99172778
11MP0000751_myopathy1.96785290
12MP0003191_abnormal_cellular_cholesterol1.96679458
13MP0005409_darkened_coat_color1.95704409
14MP0003635_abnormal_synaptic_transmissio1.94716838
15MP0005501_abnormal_skin_physiology1.92631307
16MP0005275_abnormal_skin_tensile1.91595398
17MP0002909_abnormal_adrenal_gland1.90696599
18MP0002837_dystrophic_cardiac_calcinosis1.87785193
19MP0000733_abnormal_muscle_development1.85990064
20MP0003950_abnormal_plasma_membrane1.83282455
21MP0004270_analgesia1.81002689
22MP0000759_abnormal_skeletal_muscle1.80088536
23MP0002060_abnormal_skin_morphology1.77806120
24MP0003705_abnormal_hypodermis_morpholog1.74917570
25MP0002332_abnormal_exercise_endurance1.70985257
26MP0004215_abnormal_myocardial_fiber1.70902443
27MP0004084_abnormal_cardiac_muscle1.60838775
28MP0003453_abnormal_keratinocyte_physiol1.60435461
29MP0000750_abnormal_muscle_regeneration1.60328539
30MP0003091_abnormal_cell_migration1.59336760
31MP0010368_abnormal_lymphatic_system1.58640737
32MP0003122_maternal_imprinting1.58153616
33MP0005375_adipose_tissue_phenotype1.57707730
34MP0002063_abnormal_learning/memory/cond1.55361836
35MP0005623_abnormal_meninges_morphology1.55105915
36MP0000467_abnormal_esophagus_morphology1.55049745
37MP0003880_abnormal_central_pattern1.54925544
38MP0000747_muscle_weakness1.54457941
39MP0005666_abnormal_adipose_tissue1.53062725
40MP0005503_abnormal_tendon_morphology1.52983420
41MP0006138_congestive_heart_failure1.52715099
42MP0002734_abnormal_mechanical_nocicepti1.51117044
43MP0009745_abnormal_behavioral_response1.48295255
44MP0009046_muscle_twitch1.47937118
45MP0003045_fibrosis1.47253603
46MP0005248_abnormal_Harderian_gland1.46563352
47MP0001879_abnormal_lymphatic_vessel1.45111956
48MP0004782_abnormal_surfactant_physiolog1.44826642
49MP0002896_abnormal_bone_mineralization1.44710855
50MP0004130_abnormal_muscle_cell1.43306687
51MP0005187_abnormal_penis_morphology1.41662384
52MP0005023_abnormal_wound_healing1.39045687
53MP0009384_cardiac_valve_regurgitation1.38048815
54MP0001216_abnormal_epidermal_layer1.36721914
55MP0004484_altered_response_of1.34829009
56MP0002269_muscular_atrophy1.33975809
57MP0003279_aneurysm1.32909459
58MP0002254_reproductive_system_inflammat1.32907946
59MP0004264_abnormal_extraembryonic_tissu1.31252028
60MP0005646_abnormal_pituitary_gland1.28454017
61MP0001501_abnormal_sleep_pattern1.28205476
62MP0002064_seizures1.27803653
63MP0001661_extended_life_span1.26985439
64MP0004858_abnormal_nervous_system1.26680254
65MP0010678_abnormal_skin_adnexa1.24125080
66MP0001968_abnormal_touch/_nociception1.23583902
67MP0000762_abnormal_tongue_morphology1.23369535
68MP0002106_abnormal_muscle_physiology1.23171003
69MP0002572_abnormal_emotion/affect_behav1.22369643
70MP0002108_abnormal_muscle_morphology1.21986569
71MP0002972_abnormal_cardiac_muscle1.21837920
72MP0004036_abnormal_muscle_relaxation1.21051654
73MP0004085_abnormal_heartbeat1.21029444
74MP0005167_abnormal_blood-brain_barrier1.20068730
75MP0005670_abnormal_white_adipose1.19142243
76MP0001486_abnormal_startle_reflex1.18121579
77MP0002971_abnormal_brown_adipose1.17611313
78MP0005369_muscle_phenotype1.16979153
79MP0008004_abnormal_stomach_pH1.16961118
80MP0005620_abnormal_muscle_contractility1.16727625
81MP0003283_abnormal_digestive_organ1.14624391
82MP0001299_abnormal_eye_distance/1.14320957
83MP0005076_abnormal_cell_differentiation1.12544839
84MP0003868_abnormal_feces_composition1.10754588
85MP0008775_abnormal_heart_ventricle1.10263070
86MP0002876_abnormal_thyroid_physiology1.09633231
87MP0000377_abnormal_hair_follicle1.09477049
88MP0004885_abnormal_endolymph1.08981671
89MP0001346_abnormal_lacrimal_gland1.08135712
90MP0009840_abnormal_foam_cell1.08123071
91MP0000579_abnormal_nail_morphology1.07891290
92MP0002735_abnormal_chemical_nociception1.06189593
93MP0002272_abnormal_nervous_system1.06133270
94MP0000003_abnormal_adipose_tissue1.05604372
95MP0005645_abnormal_hypothalamus_physiol1.05533080
96MP0010386_abnormal_urinary_bladder1.04478461
97MP0002234_abnormal_pharynx_morphology1.04051659
98MP0002557_abnormal_social/conspecific_i1.04004982
99MP0001177_atelectasis1.03697139
100MP0000537_abnormal_urethra_morphology1.03008206
101MP0002098_abnormal_vibrissa_morphology1.02432404
102MP0000627_abnormal_mammary_gland1.01523988
103MP0008438_abnormal_cutaneous_collagen1.00668297
104MP0002733_abnormal_thermal_nociception0.99572027
105MP0010771_integument_phenotype0.98682006
106MP0002796_impaired_skin_barrier0.98343638
107MP0004043_abnormal_pH_regulation0.97999088
108MP0010630_abnormal_cardiac_muscle0.97920797
109MP0000767_abnormal_smooth_muscle0.97221210
110MP0005330_cardiomyopathy0.97220273
111MP0005257_abnormal_intraocular_pressure0.97113380
112MP0006276_abnormal_autonomic_nervous0.96994472
113MP0003646_muscle_fatigue0.96694651
114MP0000462_abnormal_digestive_system0.96399314
115MP0000516_abnormal_urinary_system0.93670657
116MP0005367_renal/urinary_system_phenotyp0.93670657
117MP0008569_lethality_at_weaning0.92882552
118MP0002184_abnormal_innervation0.92878675
119MP0002067_abnormal_sensory_capabilities0.90704577
120MP0003941_abnormal_skin_development0.90515243
121MP0001849_ear_inflammation0.90313037
122MP0002009_preneoplasia0.89815852
123MP0004510_myositis0.89292866
124MP0002877_abnormal_melanocyte_morpholog0.88012104
125MP0003828_pulmonary_edema0.87904090
126MP0004145_abnormal_muscle_electrophysio0.87451092
127MP0000534_abnormal_ureter_morphology0.86672326
128MP0002127_abnormal_cardiovascular_syste0.85990050
129MP0002736_abnormal_nociception_after0.85014923
130MP0001970_abnormal_pain_threshold0.84532814
131MP0000778_abnormal_nervous_system0.84517166
132MP0001958_emphysema0.84439082
133MP0003137_abnormal_impulse_conducting0.83434093
134MP0001727_abnormal_embryo_implantation0.83019565
135MP0000749_muscle_degeneration0.82788802
136MP0004087_abnormal_muscle_fiber0.82308141
137MP0005595_abnormal_vascular_smooth0.81246706
138MP0000230_abnormal_systemic_arterial0.80000703
139MP0001502_abnormal_circadian_rhythm0.79159302
140MP0005385_cardiovascular_system_phenoty0.78440840
141MP0001544_abnormal_cardiovascular_syste0.78440840
142MP0009053_abnormal_anal_canal0.77891827
143MP0003959_abnormal_lean_body0.77794859
144MP0003300_gastrointestinal_ulcer0.77689334
145MP0004924_abnormal_behavior0.77151476
146MP0005386_behavior/neurological_phenoty0.77151476
147MP0001881_abnormal_mammary_gland0.75041070
148MP0000383_abnormal_hair_follicle0.74858109
149MP0001243_abnormal_dermal_layer0.74558475
150MP0002822_catalepsy0.74104719
151MP0002295_abnormal_pulmonary_circulatio0.74088836
152MP0003195_calcinosis0.73083070
153MP0009250_abnormal_appendicular_skeleto0.72549374
154MP0004134_abnormal_chest_morphology0.72424814
155MP0002168_other_aberrant_phenotype0.72050349
156MP0001440_abnormal_grooming_behavior0.71558349
157MP0009931_abnormal_skin_appearance0.71257130
158MP0006054_spinal_hemorrhage0.71157987
159MP0010030_abnormal_orbit_morphology0.69074383

Predicted human phenotypes

RankGene SetZ-score
1Nemaline bodies (HP:0003798)4.44279109
2Muscle fiber inclusion bodies (HP:0100299)4.40026220
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.31232540
4Right ventricular cardiomyopathy (HP:0011663)3.35422309
5Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.33295883
6Distal lower limb muscle weakness (HP:0009053)3.30479269
7Focal motor seizures (HP:0011153)3.17591199
8Abnormality of nail color (HP:0100643)3.08745838
9Distal lower limb amyotrophy (HP:0008944)3.00240981
10Premature rupture of membranes (HP:0001788)2.82597551
11Centrally nucleated skeletal muscle fibers (HP:0003687)2.77602517
12Abnormality of skeletal muscle fiber size (HP:0012084)2.74525961
13Ventricular fibrillation (HP:0001663)2.68821857
14Action tremor (HP:0002345)2.65493166
15Arterial tortuosity (HP:0005116)2.60803059
16Exercise-induced muscle cramps (HP:0003710)2.60141606
17Prolonged QT interval (HP:0001657)2.59215884
18Sudden death (HP:0001699)2.57841415
19Focal seizures (HP:0007359)2.53958568
20Osteolytic defects of the hand bones (HP:0009699)2.50821497
21Osteolytic defects of the phalanges of the hand (HP:0009771)2.50821497
22Pheochromocytoma (HP:0002666)2.50497211
23Septate vagina (HP:0001153)2.48813303
24Round ear (HP:0100830)2.46744133
25Alopecia of scalp (HP:0002293)2.43108490
26Atrophic scars (HP:0001075)2.42636011
27Asymmetric septal hypertrophy (HP:0001670)2.42207223
28EMG: myopathic abnormalities (HP:0003458)2.37501318
29Syncope (HP:0001279)2.36281871
30Atrial fibrillation (HP:0005110)2.30045931
31Broad metatarsal (HP:0001783)2.28106883
32Difficulty running (HP:0009046)2.27825529
33Vertebral compression fractures (HP:0002953)2.27580504
34Neck muscle weakness (HP:0000467)2.26985241
35Overgrowth (HP:0001548)2.26002292
36Hyporeflexia of lower limbs (HP:0002600)2.25007381
37Abnormality of calcium-phosphate metabolism (HP:0100530)2.21394497
38Lower limb amyotrophy (HP:0007210)2.20789398
39Aortic dissection (HP:0002647)2.20645254
40Bundle branch block (HP:0011710)2.19357355
41Myopathic facies (HP:0002058)2.16507707
42Primary atrial arrhythmia (HP:0001692)2.15516666
43Atonic seizures (HP:0010819)2.15486589
44Hypoventilation (HP:0002791)2.14334204
45Epileptic encephalopathy (HP:0200134)2.14326403
46Agitation (HP:0000713)2.13931738
47Advanced eruption of teeth (HP:0006288)2.13594218
48Ulnar deviation of the wrist (HP:0003049)2.13175926
49Muscle hypertrophy of the lower extremities (HP:0008968)2.12652245
50Visual hallucinations (HP:0002367)2.11982246
51Mildly elevated creatine phosphokinase (HP:0008180)2.10365698
52Lip pit (HP:0100267)2.07787086
53Mitral stenosis (HP:0001718)2.06339142
54Aplasia involving bones of the upper limbs (HP:0009823)2.06173163
55Aplasia of the phalanges of the hand (HP:0009802)2.06173163
56Aplasia involving bones of the extremities (HP:0009825)2.06173163
57Distal arthrogryposis (HP:0005684)2.06014503
58Hypoplastic ischia (HP:0003175)2.04758740
59Bronchomalacia (HP:0002780)2.04055335
60Myoglobinuria (HP:0002913)2.02884920
61Hypercortisolism (HP:0001578)2.02632632
62Muscle fiber splitting (HP:0003555)2.02484943
63Rhabdomyolysis (HP:0003201)2.01313409
64Abnormality of the ischium (HP:0003174)2.01061148
65Increased variability in muscle fiber diameter (HP:0003557)2.00758602
66Broad face (HP:0000283)2.00517086
67Exercise-induced myalgia (HP:0003738)2.00268506
68Myokymia (HP:0002411)1.99799985
69Cervical subluxation (HP:0003308)1.98789575
70Calf muscle hypertrophy (HP:0008981)1.98701811
71Ventricular arrhythmia (HP:0004308)1.96883528
72Sparse lateral eyebrow (HP:0005338)1.96419387
73Asymmetry of the thorax (HP:0001555)1.95642398
74Supraventricular arrhythmia (HP:0005115)1.95095978
75Absent frontal sinuses (HP:0002688)1.94746511
76Progressive cerebellar ataxia (HP:0002073)1.94608780
77Absence seizures (HP:0002121)1.93490719
78Ketoacidosis (HP:0001993)1.93228089
79Bradycardia (HP:0001662)1.93080184
80Neuroendocrine neoplasm (HP:0100634)1.92895791
81Short nail (HP:0001799)1.92493579
82Hyperglycemia (HP:0003074)1.92453756
83Supraventricular tachycardia (HP:0004755)1.91967310
84Abnormal EKG (HP:0003115)1.91583157
85Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.90756922
86Febrile seizures (HP:0002373)1.90637129
87Germ cell neoplasia (HP:0100728)1.90316200
88Abnormality of the calf musculature (HP:0001430)1.90117633
89Reduced subcutaneous adipose tissue (HP:0003758)1.89821009
90Ventricular tachycardia (HP:0004756)1.89137703
91Abnormality of the left ventricular outflow tract (HP:0011103)1.87837367
92Subaortic stenosis (HP:0001682)1.87837367
93Wormian bones (HP:0002645)1.85867377
94Mitral valve prolapse (HP:0001634)1.84932339
95Generalized tonic-clonic seizures (HP:0002069)1.81933679
96Hypotrichosis (HP:0001006)1.80822114
97Shallow orbits (HP:0000586)1.79738798
98Difficulty climbing stairs (HP:0003551)1.79319554
99Thick nail (HP:0001805)1.77805733
100Back pain (HP:0003418)1.77797433
101Anxiety (HP:0000739)1.76865750
102Onycholysis (HP:0001806)1.76047081
103Esophageal varix (HP:0002040)1.75929126
104Plantar hyperkeratosis (HP:0007556)1.74830905
105Bulbar palsy (HP:0001283)1.74576085
106Acanthosis nigricans (HP:0000956)1.73424839
107Thin bony cortex (HP:0002753)1.73292740
108Aortic aneurysm (HP:0004942)1.73162772
109Cardiovascular calcification (HP:0011915)1.72303390
110Abnormality of the distal phalanges of the toes (HP:0010182)1.72207040
111Buphthalmos (HP:0000557)1.72164301
112Nail dystrophy (HP:0008404)1.71873412
113Insidious onset (HP:0003587)1.71809416
114Termporal pattern (HP:0011008)1.71809416
115Megalencephaly (HP:0001355)1.71567137
116Hyperventilation (HP:0002883)1.71103411
117Natal tooth (HP:0000695)1.70341695
118Popliteal pterygium (HP:0009756)1.69874584
119Hyperkalemia (HP:0002153)1.69630889
120Neonatal short-limb short stature (HP:0008921)1.69529406
121Symptomatic seizures (HP:0011145)1.69312929
122Growth hormone excess (HP:0000845)1.69181719
123Absent eyelashes (HP:0000561)1.68254911
124Ulnar bowing (HP:0003031)1.68078036
125Oligomenorrhea (HP:0000876)1.67812002
126Cerebral aneurysm (HP:0004944)1.67674069
127Spinal cord compression (HP:0002176)1.67500835
128EMG: neuropathic changes (HP:0003445)1.67388778
129Palmoplantar hyperkeratosis (HP:0000972)1.67387798
130Abnormality of the distal phalanx of the thumb (HP:0009617)1.66979245
131Milia (HP:0001056)1.66720622
132Depression (HP:0000716)1.66339445
133Abnormal social behavior (HP:0012433)1.65586744
134Impaired social interactions (HP:0000735)1.65586744
135Achilles tendon contracture (HP:0001771)1.64889425
136Spinal rigidity (HP:0003306)1.64307349
137Torticollis (HP:0000473)1.64099811
138Dysmetric saccades (HP:0000641)1.64092246
139Type 1 muscle fiber predominance (HP:0003803)1.63121407
140Ankle clonus (HP:0011448)1.62492889
141Hypoplasia of the iris (HP:0007676)1.61910222
142Hyperparathyroidism (HP:0000843)1.61886483
143Subacute progressive viral hepatitis (HP:0006572)1.61762015
144Fragile skin (HP:0001030)1.61726471
145Areflexia of lower limbs (HP:0002522)1.61379141
146Failure to thrive in infancy (HP:0001531)1.60879491
147Hepatoblastoma (HP:0002884)1.60525968
148Vascular tortuosity (HP:0004948)1.60102369
149Hyperinsulinemic hypoglycemia (HP:0000825)1.59974672
150Hamartoma of the eye (HP:0010568)1.59967434
151Postural tremor (HP:0002174)1.59839983
152Micronodular cirrhosis (HP:0001413)1.59529172
153Knee flexion contracture (HP:0006380)1.58769191
154Protrusio acetabuli (HP:0003179)1.56430956
155Truncal ataxia (HP:0002078)1.55902950
156Exotropia (HP:0000577)1.55260484
157Facial shape deformation (HP:0011334)1.54995168
158Potter facies (HP:0002009)1.54995168
159Abnormal eating behavior (HP:0100738)1.54869532
160Lymphangioma (HP:0100764)1.54551562
161Broad-based gait (HP:0002136)1.52735369
162Epileptiform EEG discharges (HP:0011182)1.52726834
163Macroorchidism (HP:0000053)1.52605497
164EEG with generalized epileptiform discharges (HP:0011198)1.52377989
165Ulnar claw (HP:0001178)1.51591364
166Abnormal atrioventricular conduction (HP:0005150)1.50968859
167Scapular winging (HP:0003691)1.50271174
168Adrenal overactivity (HP:0002717)1.49665387
169Insulin-resistant diabetes mellitus (HP:0000831)1.49353970
170Enlarged epiphyses (HP:0010580)1.48898402
171Hypsarrhythmia (HP:0002521)1.48539514
172Increased connective tissue (HP:0009025)1.48485048
173Poor eye contact (HP:0000817)1.48154970

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA23.04052627
2NTRK32.98324199
3LATS12.45997952
4EEF2K2.41416538
5TIE12.41273635
6PKN22.26971474
7FER2.17639174
8MST1R2.15465677
9FRK2.12916423
10MAP3K41.94795067
11LMTK21.93598201
12INSRR1.90680129
13CASK1.89072685
14TESK11.87274969
15MAP3K21.86563443
16PRKD31.84586257
17MAP3K91.82861429
18EPHA41.82777074
19MARK11.76126280
20RIPK11.71937155
21EPHB21.69863130
22TRPM71.64214836
23MET1.57116519
24CDK121.51827396
25MUSK1.51540689
26IRAK31.48837948
27MAP3K31.47360282
28MINK11.46973502
29AKT31.45236433
30NTRK11.43783189
31PAK31.39911027
32DDR21.37619203
33MAP2K71.35379938
34LATS21.35361803
35MAP2K41.35344314
36ICK1.35280201
37PHKG21.30933677
38PHKG11.30933677
39MAPKAPK31.24153689
40TRIB31.23016520
41NTRK21.22323458
42EPHB11.21577750
43MTOR1.21410978
44RET1.19285137
45PTK61.16767641
46SIK11.16706972
47MYLK1.15963580
48PDGFRA1.13964010
49PAK41.13606939
50CAMKK21.11968302
51SGK21.10816533
52DAPK21.09584395
53EPHA31.09520433
54CAMKK11.09487073
55PAK61.07853298
56CDC42BPA1.07586240
57WNK41.06539824
58PRKCH1.05902764
59ILK1.04859589
60OBSCN1.04280635
61PTK21.03504770
62PIK3CA1.02208360
63DMPK1.01298875
64SMG10.98980171
65CDK50.98495795
66SGK2230.98043038
67SGK4940.98043038
68FGFR20.96784352
69PLK20.94826263
70SGK30.94720826
71KSR20.94368165
72PRKCE0.94095483
73ERN10.93784461
74TGFBR20.93066627
75FGFR40.88746788
76BCR0.87941586
77STK380.87168931
78LIMK10.85734479
79CAMK1G0.85157724
80ERBB30.84013582
81PTK2B0.83867896
82MAP3K120.83577248
83PDK30.83393765
84PDK40.83393765
85ROCK10.83220250
86STK38L0.82299037
87PRPF4B0.81544671
88MAP2K10.79447002
89SIK30.78987821
90PIK3CG0.77965976
91RPS6KB20.77963074
92CAMK2A0.77572525
93FGFR30.75721843
94NEK90.75536252
95STK240.75510516
96KSR10.74826687
97ARAF0.74142343
98PRKD20.73322577
99PDK20.72121236
100LRRK20.71818638
101WNK10.70884696
102MAP3K60.70244234
103PRKAA20.68618822
104MAP3K70.68597865
105PRKD10.67361914
106PRKCG0.66660689
107PAK20.65541359
108WNK30.65469943
109GRK50.65396010
110TTN0.65085627
111MAPK120.63205099
112MAP3K10.62700724
113NEK60.62631970
114FGFR10.61780414
115STK110.59087443
116MOS0.58930207
117STK390.58398871
118CAMK2D0.57594398
119SGK10.57524346
120MAPK130.57358556
121MAP2K30.56312917
122OXSR10.54777434
123CSNK1G20.53584874
124RPS6KB10.53538867
125UHMK10.53145813
126SCYL20.52897825
127MARK20.51613223
128AKT20.51085503
129RPS6KA20.50917293
130CAMK1D0.50172255
131NUAK10.48776649
132CAMK10.48472021
133CAMK2B0.48376507
134ERBB40.48168271
135PDPK10.45964225
136TNIK0.44003914
137CHUK0.41868987
138PRKAA10.41509266
139CAMK2G0.40336127
140PDGFRB0.40176110
141ROCK20.39211073
142CAMK40.38733668
143EIF2AK10.37783527
144TAOK10.37023022
145PDK10.36893116
146GSK3A0.35617599
147CDK60.34643435
148JAK10.33655819

Predicted pathways (KEGG)

RankGene SetZ-score
1Insulin secretion_Homo sapiens_hsa049111.85892297
2Nicotine addiction_Homo sapiens_hsa050331.80145931
3Circadian entrainment_Homo sapiens_hsa047131.78853403
4GABAergic synapse_Homo sapiens_hsa047271.73372593
5Thyroid cancer_Homo sapiens_hsa052161.71133544
6Synaptic vesicle cycle_Homo sapiens_hsa047211.69735496
7Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.67318636
8Renin secretion_Homo sapiens_hsa049241.56470973
9Olfactory transduction_Homo sapiens_hsa047401.55841368
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.53643147
11Salivary secretion_Homo sapiens_hsa049701.53521433
12Dilated cardiomyopathy_Homo sapiens_hsa054141.52849578
13Renal cell carcinoma_Homo sapiens_hsa052111.52138466
14Nitrogen metabolism_Homo sapiens_hsa009101.51542973
15Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.50630323
16Amphetamine addiction_Homo sapiens_hsa050311.50045882
17Morphine addiction_Homo sapiens_hsa050321.47506453
18Gastric acid secretion_Homo sapiens_hsa049711.47095929
19Long-term potentiation_Homo sapiens_hsa047201.46597608
20Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.43384701
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.42732206
22Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.41637922
23Glutamatergic synapse_Homo sapiens_hsa047241.40477660
24Phenylalanine metabolism_Homo sapiens_hsa003601.39789464
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.39419691
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.36568290
27Dopaminergic synapse_Homo sapiens_hsa047281.32701660
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.31811544
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.31190772
30Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.29728228
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.29214221
32mTOR signaling pathway_Homo sapiens_hsa041501.27809511
33AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.27258720
34Taste transduction_Homo sapiens_hsa047421.26928944
35Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.26332812
36Cholinergic synapse_Homo sapiens_hsa047251.25508725
37Inositol phosphate metabolism_Homo sapiens_hsa005621.23194790
38Chronic myeloid leukemia_Homo sapiens_hsa052201.22571831
39ECM-receptor interaction_Homo sapiens_hsa045121.22486797
40Small cell lung cancer_Homo sapiens_hsa052221.21521499
41Cocaine addiction_Homo sapiens_hsa050301.21244488
42Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.17627664
43Central carbon metabolism in cancer_Homo sapiens_hsa052301.17172074
44VEGF signaling pathway_Homo sapiens_hsa043701.15595911
45Acute myeloid leukemia_Homo sapiens_hsa052211.14463965
46Type II diabetes mellitus_Homo sapiens_hsa049301.13662582
47Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.11172865
48Pancreatic cancer_Homo sapiens_hsa052121.10810543
49cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09463327
50Oxytocin signaling pathway_Homo sapiens_hsa049211.09323271
51Vascular smooth muscle contraction_Homo sapiens_hsa042701.07844544
52Sulfur metabolism_Homo sapiens_hsa009201.04373829
53Prostate cancer_Homo sapiens_hsa052151.04292908
54Calcium signaling pathway_Homo sapiens_hsa040201.02900377
55Melanogenesis_Homo sapiens_hsa049161.02551341
56Long-term depression_Homo sapiens_hsa047301.00845013
57Serotonergic synapse_Homo sapiens_hsa047261.00764663
58Gap junction_Homo sapiens_hsa045401.00469048
59cAMP signaling pathway_Homo sapiens_hsa040240.99839058
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.99011637
61Focal adhesion_Homo sapiens_hsa045100.98533188
62Cardiac muscle contraction_Homo sapiens_hsa042600.98463444
63GnRH signaling pathway_Homo sapiens_hsa049120.97719909
64Axon guidance_Homo sapiens_hsa043600.97550118
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.97081015
66Pancreatic secretion_Homo sapiens_hsa049720.96594700
67Non-small cell lung cancer_Homo sapiens_hsa052230.96407170
68Estrogen signaling pathway_Homo sapiens_hsa049150.95407047
69Regulation of actin cytoskeleton_Homo sapiens_hsa048100.95292562
70Protein digestion and absorption_Homo sapiens_hsa049740.95161788
71Fatty acid biosynthesis_Homo sapiens_hsa000610.92735248
72Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.92065784
73Thyroid hormone synthesis_Homo sapiens_hsa049180.90284500
74Prolactin signaling pathway_Homo sapiens_hsa049170.88986927
75Pentose phosphate pathway_Homo sapiens_hsa000300.88679593
76Bile secretion_Homo sapiens_hsa049760.88546878
77Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.88336470
78Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.88181381
79Glucagon signaling pathway_Homo sapiens_hsa049220.88003095
80Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.86892515
81Butanoate metabolism_Homo sapiens_hsa006500.86291779
82Leukocyte transendothelial migration_Homo sapiens_hsa046700.86031020
83Dorso-ventral axis formation_Homo sapiens_hsa043200.84095458
84Choline metabolism in cancer_Homo sapiens_hsa052310.83135099
85Propanoate metabolism_Homo sapiens_hsa006400.82636080
86Tight junction_Homo sapiens_hsa045300.82328903
87Bladder cancer_Homo sapiens_hsa052190.82276149
88Galactose metabolism_Homo sapiens_hsa000520.80632395
89Adherens junction_Homo sapiens_hsa045200.80365067
90Vibrio cholerae infection_Homo sapiens_hsa051100.79487601
91Fatty acid metabolism_Homo sapiens_hsa012120.77778704
92FoxO signaling pathway_Homo sapiens_hsa040680.75782195
93Glycosaminoglycan degradation_Homo sapiens_hsa005310.75587142
94Collecting duct acid secretion_Homo sapiens_hsa049660.74529138
95Glioma_Homo sapiens_hsa052140.73593240
96Fatty acid elongation_Homo sapiens_hsa000620.73563209
97Sphingolipid metabolism_Homo sapiens_hsa006000.72094602
98Fatty acid degradation_Homo sapiens_hsa000710.70994797
99Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.69768535
100Circadian rhythm_Homo sapiens_hsa047100.69473252
101TGF-beta signaling pathway_Homo sapiens_hsa043500.68712831
102Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.66583721
103Insulin resistance_Homo sapiens_hsa049310.65926420
104Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65732708
105Endometrial cancer_Homo sapiens_hsa052130.65307732
106Vitamin B6 metabolism_Homo sapiens_hsa007500.65307700
107Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.65236902
108Proteoglycans in cancer_Homo sapiens_hsa052050.65217043
109ErbB signaling pathway_Homo sapiens_hsa040120.64621328
110Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64541040
111Ovarian steroidogenesis_Homo sapiens_hsa049130.64176581
112Rap1 signaling pathway_Homo sapiens_hsa040150.64116424
113Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.63696252
114PPAR signaling pathway_Homo sapiens_hsa033200.63612463
115Hippo signaling pathway_Homo sapiens_hsa043900.63565517
116Insulin signaling pathway_Homo sapiens_hsa049100.62561091
117Prion diseases_Homo sapiens_hsa050200.61552403
118Hepatitis C_Homo sapiens_hsa051600.61457769
119Arginine and proline metabolism_Homo sapiens_hsa003300.61207529
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.61153134
121Hedgehog signaling pathway_Homo sapiens_hsa043400.60379474
122MicroRNAs in cancer_Homo sapiens_hsa052060.60326062
123PI3K-Akt signaling pathway_Homo sapiens_hsa041510.60033614
124Colorectal cancer_Homo sapiens_hsa052100.58746483
125Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58140208
126Platelet activation_Homo sapiens_hsa046110.57856955
127Amoebiasis_Homo sapiens_hsa051460.57524162
128Endocytosis_Homo sapiens_hsa041440.57364251
129Pathways in cancer_Homo sapiens_hsa052000.56820525
130Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.56264175
131Ras signaling pathway_Homo sapiens_hsa040140.54728163
132Adipocytokine signaling pathway_Homo sapiens_hsa049200.54546269
133Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54517615
134Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53571421
135Notch signaling pathway_Homo sapiens_hsa043300.53264544
136Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52429758
137Arginine biosynthesis_Homo sapiens_hsa002200.51665100
138Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.51650996
139Wnt signaling pathway_Homo sapiens_hsa043100.51583226
140Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50610648
141Melanoma_Homo sapiens_hsa052180.50573899
142Phospholipase D signaling pathway_Homo sapiens_hsa040720.50514658
143Tyrosine metabolism_Homo sapiens_hsa003500.50468333
144Basal cell carcinoma_Homo sapiens_hsa052170.49854002
145AMPK signaling pathway_Homo sapiens_hsa041520.49831333
146Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49484782

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