MICU3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane assembly (GO:0097105)5.24529158
2vocalization behavior (GO:0071625)5.23040723
3neuron cell-cell adhesion (GO:0007158)5.23036754
4synaptic vesicle exocytosis (GO:0016079)5.19061549
5cellular potassium ion homeostasis (GO:0030007)5.18855586
6negative regulation of dendrite morphogenesis (GO:0050774)5.12263744
7neuronal action potential propagation (GO:0019227)5.03922308
8presynaptic membrane organization (GO:0097090)4.86964703
9regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.68596902
10regulation of short-term neuronal synaptic plasticity (GO:0048172)4.63755895
11regulation of synaptic vesicle exocytosis (GO:2000300)4.62255579
12sodium ion export (GO:0071436)4.59668812
13glutamate secretion (GO:0014047)4.54430983
14regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.53087520
15protein localization to synapse (GO:0035418)4.49864355
16postsynaptic membrane organization (GO:0001941)4.48316607
17negative regulation of synaptic transmission, GABAergic (GO:0032229)4.42427725
18neurotransmitter-gated ion channel clustering (GO:0072578)4.38039068
19positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.24674623
20synaptic vesicle docking involved in exocytosis (GO:0016081)4.21631954
21regulation of synaptic vesicle transport (GO:1902803)4.09615106
22regulation of glutamate receptor signaling pathway (GO:1900449)4.09607097
23neurotransmitter secretion (GO:0007269)3.97088615
24neuron-neuron synaptic transmission (GO:0007270)3.91730815
25cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.88875316
26auditory behavior (GO:0031223)3.86274950
27negative regulation of dendrite development (GO:2000171)3.84844989
28gamma-aminobutyric acid signaling pathway (GO:0007214)3.84183817
29dendritic spine morphogenesis (GO:0060997)3.80537611
30membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.76812047
31synaptic transmission, glutamatergic (GO:0035249)3.73100280
32ionotropic glutamate receptor signaling pathway (GO:0035235)3.72864348
33glutamate receptor signaling pathway (GO:0007215)3.64787033
34synaptic vesicle maturation (GO:0016188)3.60786499
35regulation of synapse structural plasticity (GO:0051823)3.56780113
36neuronal ion channel clustering (GO:0045161)3.55622098
37axonal fasciculation (GO:0007413)3.53758471
38cellular sodium ion homeostasis (GO:0006883)3.52344914
39transferrin transport (GO:0033572)3.51269764
40potassium ion homeostasis (GO:0055075)3.48856011
41central nervous system myelination (GO:0022010)3.47212098
42axon ensheathment in central nervous system (GO:0032291)3.47212098
43potassium ion import (GO:0010107)3.45293722
44cerebellar granule cell differentiation (GO:0021707)3.42828844
45negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.42375406
46L-amino acid import (GO:0043092)3.41532645
47ATP hydrolysis coupled proton transport (GO:0015991)3.40487948
48energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.40487948
49regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.38508152
50regulation of excitatory postsynaptic membrane potential (GO:0060079)3.37792461
51long-term synaptic potentiation (GO:0060291)3.36676204
52inositol phosphate catabolic process (GO:0071545)3.35564828
53positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.35403582
54startle response (GO:0001964)3.35389434
55cell communication by electrical coupling (GO:0010644)3.35363074
56regulation of synapse maturation (GO:0090128)3.34564439
57positive regulation of synapse assembly (GO:0051965)3.34433649
58layer formation in cerebral cortex (GO:0021819)3.31745450
59neurotransmitter transport (GO:0006836)3.31393129
60regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.30607119
61regulation of dendritic spine morphogenesis (GO:0061001)3.29094956
62positive regulation of dendritic spine development (GO:0060999)3.28954402
63locomotory exploration behavior (GO:0035641)3.27189573
64trivalent inorganic cation transport (GO:0072512)3.26925544
65ferric iron transport (GO:0015682)3.26925544
66positive regulation of dendritic spine morphogenesis (GO:0061003)3.25974871
67striatum development (GO:0021756)3.25313102
68regulation of synaptic transmission, glutamatergic (GO:0051966)3.24542729
69regulation of neuronal synaptic plasticity (GO:0048168)3.23147483
70regulation of postsynaptic membrane potential (GO:0060078)3.22342173
71cell migration in hindbrain (GO:0021535)3.21027217
72mechanosensory behavior (GO:0007638)3.20980741
73regulation of neurotransmitter secretion (GO:0046928)3.20077927
74regulation of glutamate secretion (GO:0014048)3.19602768
75cerebellar Purkinje cell differentiation (GO:0021702)3.18545967
76synapse assembly (GO:0007416)3.17713446
77membrane depolarization during action potential (GO:0086010)3.17671997
78adult walking behavior (GO:0007628)3.17517746
79serotonin receptor signaling pathway (GO:0007210)3.16631732
80exploration behavior (GO:0035640)3.15503041
81G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.15118521
82transmission of nerve impulse (GO:0019226)3.14901821
83cell differentiation in hindbrain (GO:0021533)3.13935856
84neuron recognition (GO:0008038)3.12842497
85long-term memory (GO:0007616)3.12266708
86gamma-aminobutyric acid transport (GO:0015812)3.10948891
87response to histamine (GO:0034776)3.09486285
88positive regulation of membrane potential (GO:0045838)3.06471040
89amino acid import (GO:0043090)3.05724593
90regulation of long-term neuronal synaptic plasticity (GO:0048169)3.05621949
91innervation (GO:0060384)3.05315172
92neurofilament cytoskeleton organization (GO:0060052)3.05095865
93C4-dicarboxylate transport (GO:0015740)3.04166887
94response to auditory stimulus (GO:0010996)3.03578949
95positive regulation of synapse maturation (GO:0090129)3.02496866
96neuromuscular synaptic transmission (GO:0007274)3.01906352
97positive regulation of synaptic transmission, GABAergic (GO:0032230)3.01525368
98membrane depolarization (GO:0051899)3.01059678
99synaptic vesicle endocytosis (GO:0048488)3.00438993
100regulation of dendritic spine development (GO:0060998)3.00363540
101regulation of neurotransmitter levels (GO:0001505)2.99761073
102neurotransmitter uptake (GO:0001504)2.99524743
103regulation of neurotransmitter transport (GO:0051588)2.98691962
104regulation of synaptic transmission, GABAergic (GO:0032228)2.97365428
105regulation of vesicle fusion (GO:0031338)2.95766130
106regulation of synaptic plasticity (GO:0048167)2.92375299
107synaptic transmission (GO:0007268)2.91961526
108positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.90987206
109calcium ion-dependent exocytosis (GO:0017156)2.89431458
110negative regulation of cytosolic calcium ion concentration (GO:0051481)2.86754243
111serotonin metabolic process (GO:0042428)2.85812737
112retinal cone cell development (GO:0046549)2.85081493
113positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.84928411
114synaptic vesicle transport (GO:0048489)2.84710491
115establishment of synaptic vesicle localization (GO:0097480)2.84710491
116positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.84655680
117behavioral response to cocaine (GO:0048148)2.83979962
118female mating behavior (GO:0060180)2.83846301
119positive regulation of neurotransmitter transport (GO:0051590)2.83318701
120regulation of cell communication by electrical coupling (GO:0010649)2.83070208
121neuromuscular process controlling posture (GO:0050884)2.82289123
122neuronal action potential (GO:0019228)2.80073349
123regulation of synaptic transmission (GO:0050804)2.79943687
124regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.79884219
125dendrite development (GO:0016358)2.79729412
126negative regulation of neurotransmitter transport (GO:0051589)2.79611972
127learning (GO:0007612)2.79256392
128protein localization to cilium (GO:0061512)2.79255139
129regulation of protein kinase A signaling (GO:0010738)2.77687947
130proline transport (GO:0015824)2.77079331
131regulation of synapse assembly (GO:0051963)2.76815256
132positive regulation of synaptic transmission (GO:0050806)2.76586859
133detection of calcium ion (GO:0005513)2.76287199
134regulation of voltage-gated calcium channel activity (GO:1901385)2.74791605
135calcium-mediated signaling using intracellular calcium source (GO:0035584)2.74689335

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.05954286
2GBX2_23144817_ChIP-Seq_PC3_Human4.65892430
3TAF15_26573619_Chip-Seq_HEK293_Human3.16321687
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.96322002
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.77204677
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.75395605
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.61901219
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.46997296
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.42440507
10REST_21632747_ChIP-Seq_MESCs_Mouse2.38300138
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.34317999
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.29436533
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.28817643
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.28079167
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.26837611
16EZH2_18974828_ChIP-Seq_MESCs_Mouse2.26837611
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.26699356
18BMI1_23680149_ChIP-Seq_NPCS_Mouse2.16833516
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.16126361
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.15238379
21CTBP1_25329375_ChIP-Seq_LNCAP_Human2.14041713
22SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.10548273
23MTF2_20144788_ChIP-Seq_MESCs_Mouse2.07449369
24P300_19829295_ChIP-Seq_ESCs_Human2.05963007
25POU3F2_20337985_ChIP-ChIP_501MEL_Human2.05305345
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.01872409
27SMAD4_21799915_ChIP-Seq_A2780_Human1.99951826
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.94945369
29REST_18959480_ChIP-ChIP_MESCs_Mouse1.91094191
30CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.88056549
31RNF2_27304074_Chip-Seq_ESCs_Mouse1.83735704
32PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.80976261
33SUZ12_27294783_Chip-Seq_ESCs_Mouse1.79841243
34EZH2_27294783_Chip-Seq_ESCs_Mouse1.79325712
35VDR_22108803_ChIP-Seq_LS180_Human1.79029481
36IGF1R_20145208_ChIP-Seq_DFB_Human1.76528116
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.73060876
38AR_21572438_ChIP-Seq_LNCaP_Human1.72745577
39RARB_27405468_Chip-Seq_BRAIN_Mouse1.69065108
40TOP2B_26459242_ChIP-Seq_MCF-7_Human1.67559190
41RNF2_27304074_Chip-Seq_NSC_Mouse1.67296431
42FUS_26573619_Chip-Seq_HEK293_Human1.63193055
43PIAS1_25552417_ChIP-Seq_VCAP_Human1.61748344
44CBX2_27304074_Chip-Seq_ESCs_Mouse1.59841670
45OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.58325729
46SMAD_19615063_ChIP-ChIP_OVARY_Human1.56350444
47SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.56299145
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.55204823
49AR_25329375_ChIP-Seq_VCAP_Human1.50592243
50BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.50050667
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.47912655
52IKZF1_21737484_ChIP-ChIP_HCT116_Human1.47646662
53PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.44794545
54DROSHA_22980978_ChIP-Seq_HELA_Human1.43454265
55STAT3_23295773_ChIP-Seq_U87_Human1.38880572
56UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.35662609
57ER_23166858_ChIP-Seq_MCF-7_Human1.35530855
58NR3C1_23031785_ChIP-Seq_PC12_Mouse1.32845401
59ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.31601172
60RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.28880485
61SOX2_21211035_ChIP-Seq_LN229_Gbm1.28099797
62FLI1_27457419_Chip-Seq_LIVER_Mouse1.26840657
63NANOG_18555785_Chip-Seq_ESCs_Mouse1.25432115
64RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.24926386
65RING1B_27294783_Chip-Seq_ESCs_Mouse1.24816345
66TCF4_23295773_ChIP-Seq_U87_Human1.24400168
67CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24225557
68AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24183147
69JUN_21703547_ChIP-Seq_K562_Human1.23831524
70CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.23783030
71FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.23698255
72RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.22905869
73TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20815351
74TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.20359371
75RUNX2_22187159_ChIP-Seq_PCA_Human1.19777251
76PRDM14_20953172_ChIP-Seq_ESCs_Human1.18648115
77PCGF2_27294783_Chip-Seq_ESCs_Mouse1.15929885
78YAP1_20516196_ChIP-Seq_MESCs_Mouse1.14938282
79ZNF274_21170338_ChIP-Seq_K562_Hela1.13879185
80LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12918997
81ARNT_22903824_ChIP-Seq_MCF-7_Human1.12220120
82E2F1_18555785_Chip-Seq_ESCs_Mouse1.12183641
83WT1_25993318_ChIP-Seq_PODOCYTE_Human1.11944423
84TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11532993
85POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11532993
86MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10122114
87P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09883102
88RBPJ_22232070_ChIP-Seq_NCS_Mouse1.09809453
89P53_22387025_ChIP-Seq_ESCs_Mouse1.09351562
90EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.08858942
91MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08835444
92KDM2B_26808549_Chip-Seq_REH_Human1.08774907
93PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.08431945
94TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07947463
95EWS_26573619_Chip-Seq_HEK293_Human1.06069740
96AHR_22903824_ChIP-Seq_MCF-7_Human1.04410339
97EP300_21415370_ChIP-Seq_HL-1_Mouse1.03513396
98MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02892063
99BCAT_22108803_ChIP-Seq_LS180_Human1.02599505
100CMYC_18555785_Chip-Seq_ESCs_Mouse1.02390745
101TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.01369357
102ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.01302254
103TP53_18474530_ChIP-ChIP_U2OS_Human1.01196147
104SUZ12_18555785_Chip-Seq_ESCs_Mouse1.00434720
105SOX9_26525672_Chip-Seq_HEART_Mouse0.99777438
106KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.99674919
107CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.99192688
108MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.99036956
109STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.98359238
110TP53_16413492_ChIP-PET_HCT116_Human0.97281311
111NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97089241
112AR_19668381_ChIP-Seq_PC3_Human0.96492065
113FLI1_21867929_ChIP-Seq_TH2_Mouse0.96355630
114RING1B_27294783_Chip-Seq_NPCs_Mouse0.95675826
115ZNF217_24962896_ChIP-Seq_MCF-7_Human0.95412316
116CDX2_19796622_ChIP-Seq_MESCs_Mouse0.95231335
117EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.95017440
118EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.94162545
119TAL1_26923725_Chip-Seq_HPCs_Mouse0.94042882
120STAT3_18555785_Chip-Seq_ESCs_Mouse0.93956897

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.04018347
2MP0004859_abnormal_synaptic_plasticity4.10794499
3MP0004270_analgesia3.55840347
4MP0002735_abnormal_chemical_nociception3.50650168
5MP0003635_abnormal_synaptic_transmissio3.45701381
6MP0009046_muscle_twitch3.45636361
7MP0001968_abnormal_touch/_nociception3.41688821
8MP0009745_abnormal_behavioral_response3.19537756
9MP0002736_abnormal_nociception_after3.08543790
10MP0002064_seizures2.97440435
11MP0002734_abnormal_mechanical_nocicepti2.86509856
12MP0002063_abnormal_learning/memory/cond2.82752359
13MP0002272_abnormal_nervous_system2.79662520
14MP0006276_abnormal_autonomic_nervous2.78725243
15MP0002572_abnormal_emotion/affect_behav2.62820317
16MP0001188_hyperpigmentation2.56698344
17MP0002067_abnormal_sensory_capabilities2.30489488
18MP0001486_abnormal_startle_reflex2.24789406
19MP0001501_abnormal_sleep_pattern2.21387874
20MP0001984_abnormal_olfaction2.15461107
21MP0001970_abnormal_pain_threshold2.14244148
22MP0002733_abnormal_thermal_nociception2.14153362
23MP0001986_abnormal_taste_sensitivity2.08528588
24MP0003787_abnormal_imprinting2.04563824
25MP0005646_abnormal_pituitary_gland1.99538556
26MP0001440_abnormal_grooming_behavior1.98619609
27MP0001529_abnormal_vocalization1.96105915
28MP0002184_abnormal_innervation1.96037427
29MP0002822_catalepsy1.92574547
30MP0004142_abnormal_muscle_tone1.91466528
31MP0003122_maternal_imprinting1.81349454
32MP0005423_abnormal_somatic_nervous1.74361816
33MP0003879_abnormal_hair_cell1.74277474
34MP0002557_abnormal_social/conspecific_i1.71113136
35MP0008569_lethality_at_weaning1.71105755
36MP0004924_abnormal_behavior1.66770235
37MP0005386_behavior/neurological_phenoty1.66770235
38MP0002876_abnormal_thyroid_physiology1.64986461
39MP0001905_abnormal_dopamine_level1.59319828
40MP0005645_abnormal_hypothalamus_physiol1.58065854
41MP0000778_abnormal_nervous_system1.55678099
42MP0009780_abnormal_chondrocyte_physiolo1.49341511
43MP0000569_abnormal_digit_pigmentation1.43934717
44MP0004858_abnormal_nervous_system1.43869134
45MP0005171_absent_coat_pigmentation1.41211856
46MP0004811_abnormal_neuron_physiology1.38443436
47MP0003123_paternal_imprinting1.37341158
48MP0000955_abnormal_spinal_cord1.37216736
49MP0002882_abnormal_neuron_morphology1.31828723
50MP0002066_abnormal_motor_capabilities/c1.29217517
51MP0010386_abnormal_urinary_bladder1.23423144
52MP0002837_dystrophic_cardiac_calcinosis1.20747471
53MP0001502_abnormal_circadian_rhythm1.19601600
54MP0001963_abnormal_hearing_physiology1.11860159
55MP0002751_abnormal_autonomic_nervous1.09254866
56MP0004742_abnormal_vestibular_system1.07543232
57MP0005409_darkened_coat_color1.07312202
58MP0003690_abnormal_glial_cell1.07274133
59MP0000920_abnormal_myelination1.06665403
60MP0002909_abnormal_adrenal_gland1.04528538
61MP0002229_neurodegeneration1.04128217
62MP0004147_increased_porphyrin_level1.01949439
63MP0003633_abnormal_nervous_system0.99365059
64MP0004145_abnormal_muscle_electrophysio0.98945264
65MP0005394_taste/olfaction_phenotype0.98517552
66MP0005499_abnormal_olfactory_system0.98517552
67MP0001299_abnormal_eye_distance/0.98458456
68MP0000015_abnormal_ear_pigmentation0.96087789
69MP0005551_abnormal_eye_electrophysiolog0.96075244
70MP0003329_amyloid_beta_deposits0.95846011
71MP0002752_abnormal_somatic_nervous0.92664158
72MP0005187_abnormal_penis_morphology0.89882729
73MP0000751_myopathy0.87796870
74MP0003631_nervous_system_phenotype0.87528788
75MP0006072_abnormal_retinal_apoptosis0.86930250
76MP0000631_abnormal_neuroendocrine_gland0.86070479
77MP0002152_abnormal_brain_morphology0.85604427
78MP0008872_abnormal_physiological_respon0.85498068
79MP0004085_abnormal_heartbeat0.84904620
80MP0002069_abnormal_eating/drinking_beha0.83089320
81MP0003183_abnormal_peptide_metabolism0.82896457
82MP0008877_abnormal_DNA_methylation0.82771811
83MP0001485_abnormal_pinna_reflex0.81236365
84MP0000013_abnormal_adipose_tissue0.79929830
85MP0000026_abnormal_inner_ear0.79404048
86MP0002638_abnormal_pupillary_reflex0.78948829
87MP0001348_abnormal_lacrimal_gland0.76764685
88MP0001664_abnormal_digestion0.76307117
89MP0005623_abnormal_meninges_morphology0.76281995
90MP0003646_muscle_fatigue0.75910882
91MP0000372_irregular_coat_pigmentation0.75714336
92MP0003121_genomic_imprinting0.75402666
93MP0005535_abnormal_body_temperature0.72105864
94MP0005253_abnormal_eye_physiology0.71777834
95MP0003283_abnormal_digestive_organ0.71468709
96MP0004484_altered_response_of0.71109120
97MP0003136_yellow_coat_color0.71085995
98MP0004885_abnormal_endolymph0.69347016
99MP0005167_abnormal_blood-brain_barrier0.69088379
100MP0009379_abnormal_foot_pigmentation0.69025201
101MP0008874_decreased_physiological_sensi0.68200891
102MP0003137_abnormal_impulse_conducting0.68196501
103MP0001177_atelectasis0.67406231
104MP0003861_abnormal_nervous_system0.66303969
105MP0006292_abnormal_olfactory_placode0.63982465
106MP0008260_abnormal_autophagy0.63915103
107MP0004043_abnormal_pH_regulation0.63695964
108MP0004215_abnormal_myocardial_fiber0.62537065
109MP0001943_abnormal_respiration0.61910333
110MP0003634_abnormal_glial_cell0.61805889
111MP0006035_abnormal_mitochondrial_morpho0.61280835
112MP0008789_abnormal_olfactory_epithelium0.59239445
113MP0010769_abnormal_survival0.58877258
114MP0002160_abnormal_reproductive_system0.57881330
115MP0002082_postnatal_lethality0.57665764
116MP0010770_preweaning_lethality0.57665764
117MP0000534_abnormal_ureter_morphology0.56278326
118MP0010768_mortality/aging0.55752459
119MP0002102_abnormal_ear_morphology0.53115291
120MP0003632_abnormal_nervous_system0.53032143
121MP0000566_synostosis0.52773628
122MP0000639_abnormal_adrenal_gland0.52188678

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.93528871
2Atonic seizures (HP:0010819)6.16199363
3Febrile seizures (HP:0002373)5.73697618
4Epileptic encephalopathy (HP:0200134)5.32180660
5Myokymia (HP:0002411)5.11847692
6Focal seizures (HP:0007359)4.82958460
7Hyperventilation (HP:0002883)4.36817714
8Absence seizures (HP:0002121)4.28196411
9Progressive cerebellar ataxia (HP:0002073)3.99588427
10Dialeptic seizures (HP:0011146)3.95166067
11Abnormal hair whorl (HP:0010721)3.84669986
12Hypothermia (HP:0002045)3.84369263
13Pheochromocytoma (HP:0002666)3.56182253
14Generalized tonic-clonic seizures (HP:0002069)3.39834034
15Neuroendocrine neoplasm (HP:0100634)3.39460126
16Gait imbalance (HP:0002141)3.38561274
17Visual hallucinations (HP:0002367)3.35982420
18Gaze-evoked nystagmus (HP:0000640)3.32233983
19Hemiparesis (HP:0001269)3.28980141
20Supranuclear gaze palsy (HP:0000605)3.28863261
21Medial flaring of the eyebrow (HP:0010747)3.28808646
22Status epilepticus (HP:0002133)3.22885591
23Acute necrotizing encephalopathy (HP:0006965)3.18377457
24Congenital primary aphakia (HP:0007707)3.17566859
25Intention tremor (HP:0002080)3.13596574
26Broad-based gait (HP:0002136)3.11492770
27Nephrogenic diabetes insipidus (HP:0009806)3.07848814
28Torticollis (HP:0000473)3.02586586
29Abnormal mitochondria in muscle tissue (HP:0008316)2.99083989
30Action tremor (HP:0002345)2.96377780
31Postural instability (HP:0002172)2.90593175
32Papilledema (HP:0001085)2.89373346
33Progressive macrocephaly (HP:0004481)2.87677102
34Failure to thrive in infancy (HP:0001531)2.72167894
35Mitochondrial inheritance (HP:0001427)2.70409334
36Fetal akinesia sequence (HP:0001989)2.66366437
37Amblyopia (HP:0000646)2.66186595
38Poor suck (HP:0002033)2.63791064
39Limb dystonia (HP:0002451)2.63069490
40Progressive inability to walk (HP:0002505)2.59674449
41Genital tract atresia (HP:0001827)2.59512537
42Abnormal eating behavior (HP:0100738)2.57691351
43Mutism (HP:0002300)2.57392696
44Hemiplegia (HP:0002301)2.56916738
45Truncal ataxia (HP:0002078)2.55929975
46Cerebral hypomyelination (HP:0006808)2.53600943
47Focal dystonia (HP:0004373)2.53568146
48Vaginal atresia (HP:0000148)2.53064185
49Polyphagia (HP:0002591)2.51591273
50Scanning speech (HP:0002168)2.50514438
51Impaired vibration sensation in the lower limbs (HP:0002166)2.46825093
52Epileptiform EEG discharges (HP:0011182)2.42997869
53Neurofibrillary tangles (HP:0002185)2.41063118
54Dysdiadochokinesis (HP:0002075)2.40847909
55Poor coordination (HP:0002370)2.40749832
56Inability to walk (HP:0002540)2.35261278
57Anxiety (HP:0000739)2.35125943
58Specific learning disability (HP:0001328)2.34878864
59Hepatocellular necrosis (HP:0001404)2.34304293
60Protruding tongue (HP:0010808)2.32391227
61Oligomenorrhea (HP:0000876)2.31609156
62Increased CSF lactate (HP:0002490)2.30905105
63Acute encephalopathy (HP:0006846)2.30176384
64Absent speech (HP:0001344)2.26144549
65Degeneration of the lateral corticospinal tracts (HP:0002314)2.26037408
66Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.26037408
67Urinary urgency (HP:0000012)2.23967818
68Craniofacial dystonia (HP:0012179)2.23053648
69Lower limb muscle weakness (HP:0007340)2.22138944
70Blue irides (HP:0000635)2.20769697
71Optic disc pallor (HP:0000543)2.19427396
72EEG with generalized epileptiform discharges (HP:0011198)2.19005553
73Abnormality of ocular smooth pursuit (HP:0000617)2.18463944
74Excessive salivation (HP:0003781)2.18158541
75Drooling (HP:0002307)2.18158541
76Abnormality of the corticospinal tract (HP:0002492)2.14459632
77Abnormality of the lower motor neuron (HP:0002366)2.13518156
78Urinary bladder sphincter dysfunction (HP:0002839)2.12371304
79Obstructive sleep apnea (HP:0002870)2.11992702
80Increased circulating renin level (HP:0000848)2.08933825
81Ulnar claw (HP:0001178)2.07951084
82Ankle clonus (HP:0011448)2.07533488
83Narrow nasal bridge (HP:0000446)2.06155983
84Depression (HP:0000716)2.05222396
85Morphological abnormality of the pyramidal tract (HP:0002062)2.04321856
86Esotropia (HP:0000565)2.04051128
87Dysmetria (HP:0001310)2.03246434
88Hypsarrhythmia (HP:0002521)2.01908656
89Retinal dysplasia (HP:0007973)1.99908248
90Termporal pattern (HP:0011008)1.99519931
91Insidious onset (HP:0003587)1.99519931
92Impaired pain sensation (HP:0007328)1.97563159
93Abnormality of pain sensation (HP:0010832)1.97563159
94Poor eye contact (HP:0000817)1.96748041
95Annular pancreas (HP:0001734)1.95712641
96Spastic gait (HP:0002064)1.94483415
97Aplasia/Hypoplasia of the lens (HP:0008063)1.93023626
98Increased serum pyruvate (HP:0003542)1.89254252
99Abnormality of glycolysis (HP:0004366)1.89254252
100Cerebral inclusion bodies (HP:0100314)1.88424970
101Incomplete penetrance (HP:0003829)1.87018942
102Bradycardia (HP:0001662)1.86783109
103Impaired social interactions (HP:0000735)1.86601989
104Abnormal social behavior (HP:0012433)1.86601989
105Hypoventilation (HP:0002791)1.84870318
106Abnormality of the labia minora (HP:0012880)1.83064295
107Sleep apnea (HP:0010535)1.82815691
108Neoplasm of the peripheral nervous system (HP:0100007)1.82366151
109CNS hypomyelination (HP:0003429)1.81993292
110Akinesia (HP:0002304)1.81489481
111Impaired vibratory sensation (HP:0002495)1.81217944
112Spastic tetraplegia (HP:0002510)1.79096182
113Autoamputation (HP:0001218)1.78719512
114Generalized hypotonia (HP:0001290)1.78228769
115Bradykinesia (HP:0002067)1.78208571
116Dysmetric saccades (HP:0000641)1.76926329
117Delusions (HP:0000746)1.76759302
118Unsteady gait (HP:0002317)1.76179558
119Bundle branch block (HP:0011710)1.76069823
120Impaired smooth pursuit (HP:0007772)1.75176523
121Spastic tetraparesis (HP:0001285)1.74455587
122Megalencephaly (HP:0001355)1.72830741
123Generalized myoclonic seizures (HP:0002123)1.72741829
124Dynein arm defect of respiratory motile cilia (HP:0012255)1.72613599
125Absent/shortened dynein arms (HP:0200106)1.72613599
126Genetic anticipation (HP:0003743)1.72561180
127Abnormality of binocular vision (HP:0011514)1.72394584
128Diplopia (HP:0000651)1.72394584
129Hyperthyroidism (HP:0000836)1.70145772
130Sensory axonal neuropathy (HP:0003390)1.69109836
131Clonus (HP:0002169)1.68364920
132Aqueductal stenosis (HP:0002410)1.68342860
133Postural tremor (HP:0002174)1.67308276
134Rigidity (HP:0002063)1.65574161
135Gait ataxia (HP:0002066)1.64233154
136Prolonged QT interval (HP:0001657)1.62848875
137Lower limb asymmetry (HP:0100559)1.52790511
138Rapidly progressive (HP:0003678)1.52114131
139Amyotrophic lateral sclerosis (HP:0007354)1.51565008
140Choreoathetosis (HP:0001266)1.51101129

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK6.83465339
2NTRK33.67118720
3MAP3K123.35842509
4MAP2K73.33185878
5MAP3K42.86724490
6PRPF4B2.56230953
7MINK12.39779270
8AKT32.29359331
9EPHA42.25372644
10SIK32.23973608
11PLK22.10663289
12FRK1.97786422
13CDK191.96400442
14FGFR21.90410970
15MAP2K41.74186067
16SGK21.73764059
17MAPK131.71569073
18TNIK1.70213482
19DAPK21.63948734
20MARK11.62992869
21LATS21.62947334
22SGK2231.53160763
23SGK4941.53160763
24MAP3K91.51995276
25GRK51.44318417
26DAPK11.42721080
27PAK31.40937018
28OXSR11.40626038
29CAMKK21.31260184
30BMPR21.30934118
31ARAF1.30184159
32PRKCG1.28087423
33RIPK41.27362343
34CCNB11.25059168
35BCR1.24345881
36TSSK61.21602141
37NME11.20887244
38NTRK21.16428661
39GRK71.15236771
40PNCK1.08514932
41NTRK11.07147379
42CDK51.04075385
43CAMK2A1.02940675
44BRAF1.00853756
45SGK31.00200607
46KSR10.97734444
47RIPK10.96896493
48PRKD30.95569136
49YES10.95560001
50ADRBK20.90772089
51PRKCE0.88169911
52MUSK0.87455144
53STK110.86822010
54MKNK20.85193849
55TNK20.83063398
56CAMK2B0.83022772
57BMPR1B0.80963489
58STK380.74236009
59CAMK40.72989622
60PAK60.71811677
61FES0.70403779
62STK390.69374423
63PDK40.68112799
64PDK30.68112799
65PINK10.66627571
66WNK10.65094871
67UHMK10.64573335
68CAMKK10.63990802
69ADRBK10.63836029
70CDK180.62975579
71PKN10.61490695
72PRKCH0.60863670
73DYRK20.60737754
74CAMK2D0.59084126
75CAMK2G0.59021614
76RPS6KA30.58748743
77CDK140.57965879
78TYRO30.57114032
79PTK2B0.56929343
80MYLK0.56821076
81PRKCZ0.56776675
82WNK30.55793941
83FER0.54902122
84ERBB30.53995620
85SGK10.53168100
86CSNK1G20.52937892
87DYRK1A0.52852063
88CDK30.52294870
89MAPK100.51068605
90WNK40.50893192
91NEK60.50684105
92PHKG10.50042832
93PHKG20.50042832
94RPS6KA20.49564859
95CSNK1G10.48861116
96CDK150.48725700
97CSNK1A1L0.48009634
98MAP2K10.46497945
99PIK3CA0.45436092
100MAPK120.44757164
101CDK80.43023933
102MARK20.41938959
103PRKACA0.41397773
104CAMK10.40737648
105CDK11A0.39918261
106STK160.39860075
107ERBB40.39632551
108RET0.37802307
109CSNK1D0.36967635
110KSR20.36034348
111ROCK20.35997649
112PDK20.35373454
113CSNK1E0.35262535
114RAF10.35169794
115GRK10.34807843
116RPS6KB10.34593160
117MAP3K20.34225458
118LMTK20.33657775
119INSRR0.32912864
120PDK10.32886625
121CSNK1G30.32700641
122SIK20.31957402
123PRKCB0.31905330
124MAP3K110.31710620
125ALK0.31377166
126CAMK1G0.29987238
127PRKG10.28803982
128MAPKAPK50.28094676
129LIMK10.27955165
130CSNK1A10.27810226
131PRKCA0.26601556

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.10948322
2Synaptic vesicle cycle_Homo sapiens_hsa047214.08819367
3Collecting duct acid secretion_Homo sapiens_hsa049663.24217548
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.83844276
5Olfactory transduction_Homo sapiens_hsa047402.71905301
6GABAergic synapse_Homo sapiens_hsa047272.58324642
7Oxidative phosphorylation_Homo sapiens_hsa001902.51709681
8Morphine addiction_Homo sapiens_hsa050322.50054069
9Circadian entrainment_Homo sapiens_hsa047132.42596979
10Taste transduction_Homo sapiens_hsa047422.40796728
11Long-term potentiation_Homo sapiens_hsa047202.34809041
12Amphetamine addiction_Homo sapiens_hsa050312.28148339
13Glutamatergic synapse_Homo sapiens_hsa047242.24707247
14Dopaminergic synapse_Homo sapiens_hsa047282.15618809
15Vibrio cholerae infection_Homo sapiens_hsa051102.10570995
16Serotonergic synapse_Homo sapiens_hsa047262.01441329
17Insulin secretion_Homo sapiens_hsa049111.85833171
18Parkinsons disease_Homo sapiens_hsa050121.81024771
19Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.76505124
20Salivary secretion_Homo sapiens_hsa049701.75310428
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.70967350
22Long-term depression_Homo sapiens_hsa047301.66106865
23Alzheimers disease_Homo sapiens_hsa050101.65979939
24Cholinergic synapse_Homo sapiens_hsa047251.64136979
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.63918160
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.62110651
27Phototransduction_Homo sapiens_hsa047441.54241071
28Calcium signaling pathway_Homo sapiens_hsa040201.51594203
29Renin secretion_Homo sapiens_hsa049241.49554543
30Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.42461654
31Gastric acid secretion_Homo sapiens_hsa049711.36147487
32Cocaine addiction_Homo sapiens_hsa050301.35779748
33Huntingtons disease_Homo sapiens_hsa050161.30384330
34Aldosterone synthesis and secretion_Homo sapiens_hsa049251.28069156
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.24434221
36Oxytocin signaling pathway_Homo sapiens_hsa049211.22165945
37Cardiac muscle contraction_Homo sapiens_hsa042601.18427584
38Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.18152994
39Vitamin B6 metabolism_Homo sapiens_hsa007501.11513783
40Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.11035841
41Rheumatoid arthritis_Homo sapiens_hsa053231.09845801
42Gap junction_Homo sapiens_hsa045401.03347238
43Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.01871962
44SNARE interactions in vesicular transport_Homo sapiens_hsa041301.01752488
45GnRH signaling pathway_Homo sapiens_hsa049120.98854855
46Phosphatidylinositol signaling system_Homo sapiens_hsa040700.97005917
47cAMP signaling pathway_Homo sapiens_hsa040240.93921880
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.92768313
49Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.90720801
50Axon guidance_Homo sapiens_hsa043600.89506314
51Phagosome_Homo sapiens_hsa041450.85173424
52ErbB signaling pathway_Homo sapiens_hsa040120.84136657
53Bile secretion_Homo sapiens_hsa049760.83929511
54Melanogenesis_Homo sapiens_hsa049160.79817670
55Vascular smooth muscle contraction_Homo sapiens_hsa042700.76422152
56Type I diabetes mellitus_Homo sapiens_hsa049400.71488477
57cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71276186
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.70135554
59Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.69474207
60Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.68844980
61Estrogen signaling pathway_Homo sapiens_hsa049150.63364700
62Butanoate metabolism_Homo sapiens_hsa006500.60549279
63Oocyte meiosis_Homo sapiens_hsa041140.58426134
64MAPK signaling pathway_Homo sapiens_hsa040100.56065103
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.55971377
66Fatty acid biosynthesis_Homo sapiens_hsa000610.55697328
67Regulation of autophagy_Homo sapiens_hsa041400.54731570
68Pancreatic secretion_Homo sapiens_hsa049720.54602572
69Type II diabetes mellitus_Homo sapiens_hsa049300.53518690
70Glioma_Homo sapiens_hsa052140.53253950
71Nitrogen metabolism_Homo sapiens_hsa009100.53212706
72Ras signaling pathway_Homo sapiens_hsa040140.52541313
73Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.51916944
74Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51394130
75Pyruvate metabolism_Homo sapiens_hsa006200.49562971
76Circadian rhythm_Homo sapiens_hsa047100.49503309
77Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.48637496
78Inositol phosphate metabolism_Homo sapiens_hsa005620.48597711
79Alcoholism_Homo sapiens_hsa050340.46877954
80Thyroid hormone synthesis_Homo sapiens_hsa049180.45677747
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45619642
82Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43845260
83Melanoma_Homo sapiens_hsa052180.43434561
84Hippo signaling pathway_Homo sapiens_hsa043900.42812516
85Glucagon signaling pathway_Homo sapiens_hsa049220.41931389
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40359650
87Mineral absorption_Homo sapiens_hsa049780.38865118
88Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.38439894
89Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.36511166
90Hedgehog signaling pathway_Homo sapiens_hsa043400.34087435
91Wnt signaling pathway_Homo sapiens_hsa043100.34014598
92Dilated cardiomyopathy_Homo sapiens_hsa054140.33288418
93mTOR signaling pathway_Homo sapiens_hsa041500.32908045
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.31986816
95Tight junction_Homo sapiens_hsa045300.31275056
96Arginine biosynthesis_Homo sapiens_hsa002200.29818217
97Fatty acid elongation_Homo sapiens_hsa000620.28939756
98Rap1 signaling pathway_Homo sapiens_hsa040150.27464338
99Dorso-ventral axis formation_Homo sapiens_hsa043200.26568999
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.24958001
101Longevity regulating pathway - mammal_Homo sapiens_hsa042110.24945595
102Choline metabolism in cancer_Homo sapiens_hsa052310.24863941
103Phospholipase D signaling pathway_Homo sapiens_hsa040720.24746438
104Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.24305741
105African trypanosomiasis_Homo sapiens_hsa051430.24140813
106Arginine and proline metabolism_Homo sapiens_hsa003300.23439484
107Histidine metabolism_Homo sapiens_hsa003400.22364938
108Sphingolipid metabolism_Homo sapiens_hsa006000.22313929
109Ovarian steroidogenesis_Homo sapiens_hsa049130.21750654
110Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.21283970
111Proteasome_Homo sapiens_hsa030500.20713125
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.20485759
113Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.20374406
114Endometrial cancer_Homo sapiens_hsa052130.20223661
115Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.17442163
116Insulin signaling pathway_Homo sapiens_hsa049100.16670781
117Ether lipid metabolism_Homo sapiens_hsa005650.16562626
118Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.13279566
119Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.12653482
120Prion diseases_Homo sapiens_hsa050200.12549713

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