MICU2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vitamin transmembrane transport (GO:0035461)9.63423252
2pyrimidine-containing compound transmembrane transport (GO:0072531)9.20878312
3protein complex localization (GO:0031503)8.45304135
4mitochondrial respiratory chain complex I assembly (GO:0032981)7.51205926
5NADH dehydrogenase complex assembly (GO:0010257)7.51205926
6mitochondrial respiratory chain complex I biogenesis (GO:0097031)7.51205926
7alternative mRNA splicing, via spliceosome (GO:0000380)5.52179639
8protein complex biogenesis (GO:0070271)5.26547838
9antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.96949852
10antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.96949852
11peptidyl-arginine omega-N-methylation (GO:0035247)4.91252713
12magnesium ion transport (GO:0015693)4.90105497
13mitochondrial respiratory chain complex assembly (GO:0033108)4.83939167
14COPI coating of Golgi vesicle (GO:0048205)4.79649811
15Golgi transport vesicle coating (GO:0048200)4.79649811
16attachment of spindle microtubules to kinetochore (GO:0008608)4.73777373
17peptidyl-arginine methylation (GO:0018216)4.48818541
18peptidyl-arginine N-methylation (GO:0035246)4.48818541
19antigen processing and presentation of endogenous antigen (GO:0019883)4.30975578
20microtubule anchoring (GO:0034453)4.28503843
21azole transport (GO:0045117)4.24412093
22protein K11-linked deubiquitination (GO:0035871)4.18358023
23response to pheromone (GO:0019236)3.97895561
24DNA integration (GO:0015074)3.97553657
25nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.89948281
26neural tube formation (GO:0001841)3.80290707
27nonmotile primary cilium assembly (GO:0035058)3.77202644
28valine metabolic process (GO:0006573)3.77028323
29histone arginine methylation (GO:0034969)3.75106988
30lysine metabolic process (GO:0006553)3.70978757
31lysine catabolic process (GO:0006554)3.70978757
32lateral ventricle development (GO:0021670)3.66256348
33tricarboxylic acid metabolic process (GO:0072350)3.64832569
34positive regulation of mitochondrial fission (GO:0090141)3.60317289
35lipopolysaccharide biosynthetic process (GO:0009103)3.59865762
36protein prenylation (GO:0018342)3.56477098
37prenylation (GO:0097354)3.56477098
38L-serine metabolic process (GO:0006563)3.54975741
39positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.54891395
40mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.54891395
41regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.51416693
42maturation of 5.8S rRNA (GO:0000460)3.51227384
43oxidative demethylation (GO:0070989)3.46620423
44regulation of acyl-CoA biosynthetic process (GO:0050812)3.45393858
45platelet dense granule organization (GO:0060155)3.40773628
462-oxoglutarate metabolic process (GO:0006103)3.39560318
47mitotic G2 DNA damage checkpoint (GO:0007095)3.38404666
48regulation of cofactor metabolic process (GO:0051193)3.34401701
49regulation of coenzyme metabolic process (GO:0051196)3.34401701
50erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.31462743
51L-phenylalanine metabolic process (GO:0006558)3.31462743
52fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.29333034
53COPII vesicle coating (GO:0048208)3.29115176
54fatty acid beta-oxidation (GO:0006635)3.28787334
55ribosome assembly (GO:0042255)3.27934023
56maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.26186737
574-hydroxyproline metabolic process (GO:0019471)3.23577630
58antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.22187161
59branched-chain amino acid catabolic process (GO:0009083)3.21578188
60establishment of integrated proviral latency (GO:0075713)3.21404996
61alkaloid metabolic process (GO:0009820)3.20086663
62alpha-linolenic acid metabolic process (GO:0036109)3.19807107
63telomere maintenance via semi-conservative replication (GO:0032201)3.19239504
64homocysteine metabolic process (GO:0050667)3.18811381
65lipopolysaccharide metabolic process (GO:0008653)3.17848280
66growth hormone receptor signaling pathway (GO:0060396)3.17583123
67L-phenylalanine catabolic process (GO:0006559)3.16993667
68erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.16993667
69DNA double-strand break processing (GO:0000729)3.16962846
70replicative senescence (GO:0090399)3.15633781
71antigen processing and presentation via MHC class Ib (GO:0002475)3.14194725
72negative regulation of JUN kinase activity (GO:0043508)3.10981003
73protein localization to kinetochore (GO:0034501)3.08212035
74negative regulation of cardiac muscle tissue growth (GO:0055022)3.06606624
75negative regulation of heart growth (GO:0061117)3.06606624
76glyoxylate metabolic process (GO:0046487)3.05483791
77fatty acid oxidation (GO:0019395)3.05131162
78meiotic cell cycle (GO:0051321)3.04525587
79gene silencing by RNA (GO:0031047)3.03129721
80peptidyl-lysine dimethylation (GO:0018027)3.02611420
81protein retention in ER lumen (GO:0006621)3.00984162
82lipid oxidation (GO:0034440)2.95632354
83protein K6-linked ubiquitination (GO:0085020)2.95362316
84mitotic G2/M transition checkpoint (GO:0044818)2.94907981
85sulfur amino acid catabolic process (GO:0000098)2.94538652
86ventricular cardiac muscle cell development (GO:0055015)2.94150025
87peptidyl-threonine dephosphorylation (GO:0035970)2.89407516
88drug catabolic process (GO:0042737)2.84816807
89sequestering of metal ion (GO:0051238)2.83439275
90purine ribonucleotide transport (GO:0015868)2.83080373
91dosage compensation (GO:0007549)2.83069029
92fatty acid catabolic process (GO:0009062)2.81773552
93protein carboxylation (GO:0018214)2.81707888
94peptidyl-glutamic acid carboxylation (GO:0017187)2.81707888
95DNA strand elongation involved in DNA replication (GO:0006271)2.78451653
96regulation of fatty acid beta-oxidation (GO:0031998)2.78347242
97sister chromatid segregation (GO:0000819)2.78117899
98DNA replication-dependent nucleosome organization (GO:0034723)2.77605917
99DNA replication-dependent nucleosome assembly (GO:0006335)2.77605917
100negative regulation of Notch signaling pathway (GO:0045746)2.77382103
101mitotic recombination (GO:0006312)2.74961343
102cellular response to growth hormone stimulus (GO:0071378)2.74655901
103positive regulation of cell size (GO:0045793)2.73857637
104ribonucleoprotein complex disassembly (GO:0032988)2.71214974
105telomere maintenance via recombination (GO:0000722)2.70622867
106triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.70094787
107adenine nucleotide transport (GO:0051503)2.69535311
108DNA strand elongation (GO:0022616)2.68732743
109positive regulation of fatty acid beta-oxidation (GO:0032000)2.68636247
110negative regulation of erythrocyte differentiation (GO:0045647)2.67654449
111regulation of mitochondrial fission (GO:0090140)2.66979063
112regulation of triglyceride catabolic process (GO:0010896)2.66726399
113regulation of sulfur metabolic process (GO:0042762)2.66618890
114membrane budding (GO:0006900)2.66325286
115organelle disassembly (GO:1903008)2.65703225
116cysteine metabolic process (GO:0006534)2.62933246
117sarcomere organization (GO:0045214)2.61493630
118peptidyl-arginine modification (GO:0018195)2.61132416
119retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.60998049
120amino-acid betaine metabolic process (GO:0006577)2.60985758
121vitamin transport (GO:0051180)2.60008869
122neuron fate determination (GO:0048664)2.59811835
123regulation of fatty acid oxidation (GO:0046320)2.59502126
124regulation of DNA methylation (GO:0044030)2.58145238
125positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.57579800
126regulation of cholesterol homeostasis (GO:2000188)2.56825224
127mitotic sister chromatid segregation (GO:0000070)2.55667571
128bundle of His cell to Purkinje myocyte communication (GO:0086069)2.55651749
129carnitine metabolic process (GO:0009437)2.55306908
130microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.54459753
131labyrinthine layer development (GO:0060711)2.54387712
132deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.54310455
133nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:0000288)2.54133285
134mitotic cell cycle arrest (GO:0071850)2.52897776
135aromatic amino acid family catabolic process (GO:0009074)2.52542201
136serine family amino acid biosynthetic process (GO:0009070)2.52497089
137spindle assembly involved in mitosis (GO:0090307)2.48899150
138response to growth hormone (GO:0060416)2.48407759
139activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.48076170
140desmosome organization (GO:0002934)2.47744110
141tricarboxylic acid cycle (GO:0006099)2.47680943
142monocarboxylic acid catabolic process (GO:0072329)2.47375902
143protein localization to chromosome, centromeric region (GO:0071459)2.47176199
144JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.45878743
145nucleotide transmembrane transport (GO:1901679)2.44833222
146regulation of centrosome cycle (GO:0046605)2.44358575
147oxaloacetate metabolic process (GO:0006107)2.42729801
148positive regulation of mitochondrial membrane permeability (GO:0035794)2.41478008
149positive regulation of receptor biosynthetic process (GO:0010870)2.41258867
150positive regulation of nuclease activity (GO:0032075)2.41203673
151sulfur amino acid biosynthetic process (GO:0000097)2.41064982
152negative regulation of fibrinolysis (GO:0051918)2.40544488
153fatty acid transmembrane transport (GO:1902001)2.40213470
154cellular ketone body metabolic process (GO:0046950)2.38753673
155intestinal cholesterol absorption (GO:0030299)2.35245580
156positive regulation of fatty acid oxidation (GO:0046321)2.34678919
157positive regulation of triglyceride metabolic process (GO:0090208)2.34420720
158pentose-phosphate shunt (GO:0006098)2.34040635
159regulation of cholesterol metabolic process (GO:0090181)2.33910565
160ethanol oxidation (GO:0006069)2.33544047
161kynurenine metabolic process (GO:0070189)2.32160491
162carnitine shuttle (GO:0006853)2.31722521
163maternal placenta development (GO:0001893)2.31117305
164bile acid biosynthetic process (GO:0006699)2.30995181
165endoplasmic reticulum unfolded protein response (GO:0030968)2.30754007
166positive regulation of natural killer cell differentiation (GO:0032825)2.29223986
167positive regulation of histone deacetylation (GO:0031065)2.28366045
168branched-chain amino acid metabolic process (GO:0009081)2.26137299
169drug transmembrane transport (GO:0006855)2.25889208
170Arp2/3 complex-mediated actin nucleation (GO:0034314)2.24786267
171aspartate family amino acid catabolic process (GO:0009068)2.24646252
172positive regulation of lipid catabolic process (GO:0050996)2.23540160
173exocrine pancreas development (GO:0031017)2.23198348
174NADPH regeneration (GO:0006740)2.20415858
175urea cycle (GO:0000050)2.19850415
176urea metabolic process (GO:0019627)2.19850415
177regulation of sequestering of triglyceride (GO:0010889)2.19423135
178ethanol metabolic process (GO:0006067)2.18986480
179cellular response to unfolded protein (GO:0034620)2.18481588
180short-chain fatty acid metabolic process (GO:0046459)2.18459656
181ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.16403045
182signal peptide processing (GO:0006465)2.16274875
183primary alcohol catabolic process (GO:0034310)2.16082338
184epoxygenase P450 pathway (GO:0019373)2.15047318
185regulation of nuclease activity (GO:0032069)2.14989502
186regulation of interleukin-12 biosynthetic process (GO:0045075)2.14851824
187positive regulation of gamma-delta T cell activation (GO:0046645)2.14800426
188low-density lipoprotein particle clearance (GO:0034383)2.14654505
189ER-nucleus signaling pathway (GO:0006984)2.14533707
190positive regulation of fatty acid biosynthetic process (GO:0045723)2.14455198
191cellular response to nutrient (GO:0031670)2.13754277
192intestinal absorption (GO:0050892)2.12467550
193regulation of natural killer cell differentiation (GO:0032823)2.12189679
194xenobiotic catabolic process (GO:0042178)2.11728226
195positive regulation of triglyceride biosynthetic process (GO:0010867)2.11705902
196cellular protein complex localization (GO:0034629)12.3918065

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.02386738
2IGF1R_20145208_ChIP-Seq_DFB_Human4.57022380
3TP63_17297297_ChIP-ChIP_HaCaT_Human4.04625615
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.03804780
5RXR_22158963_ChIP-Seq_LIVER_Mouse3.58653889
6PPARA_22158963_ChIP-Seq_LIVER_Mouse3.52746943
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.21631148
8EWS_26573619_Chip-Seq_HEK293_Human3.18060578
9POU3F2_20337985_ChIP-ChIP_501MEL_Human3.15598396
10IRF8_22096565_ChIP-ChIP_GC-B_Human3.10278093
11FUS_26573619_Chip-Seq_HEK293_Human2.85601528
12LXR_22158963_ChIP-Seq_LIVER_Mouse2.73861764
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.73087486
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.70885999
15CLOCK_20551151_ChIP-Seq_293T_Human2.70686175
16TAF15_26573619_Chip-Seq_HEK293_Human2.66453613
17GATA1_22025678_ChIP-Seq_K562_Human2.55308619
18TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.50297416
19ELK1_19687146_ChIP-ChIP_HELA_Human2.30039716
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.22799468
21RARG_19884340_ChIP-ChIP_MEFs_Mouse2.19312745
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.17717192
23GABP_17652178_ChIP-ChIP_JURKAT_Human2.14267400
24KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.13851340
25ZFP57_27257070_Chip-Seq_ESCs_Mouse2.12167782
26AR_21909140_ChIP-Seq_LNCAP_Human2.03410152
27NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.03132213
28PADI4_21655091_ChIP-ChIP_MCF-7_Human2.01149018
29ZNF274_21170338_ChIP-Seq_K562_Hela2.00788909
30TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.00389372
31FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.00039360
32STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.99922376
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.99320813
34EGR1_23403033_ChIP-Seq_LIVER_Mouse1.98079648
35CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.94970860
36CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.93490454
37FOXP3_21729870_ChIP-Seq_TREG_Human1.90827846
38EGR1_19374776_ChIP-ChIP_THP-1_Human1.88409306
39MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.87103534
40NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.83862542
41VDR_23849224_ChIP-Seq_CD4+_Human1.81250735
42MYC_22102868_ChIP-Seq_BL_Human1.81091567
43IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.77744806
44VDR_22108803_ChIP-Seq_LS180_Human1.76052692
45FLI1_27457419_Chip-Seq_LIVER_Mouse1.74980804
46CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.73666170
47FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.72669180
48MYB_21317192_ChIP-Seq_ERMYB_Mouse1.70477870
49EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.69132589
50E2F4_17652178_ChIP-ChIP_JURKAT_Human1.67935448
51MYC_18940864_ChIP-ChIP_HL60_Human1.66184076
52ELF1_17652178_ChIP-ChIP_JURKAT_Human1.65954759
53NOTCH1_21737748_ChIP-Seq_TLL_Human1.63897639
54FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.63738240
55ZNF263_19887448_ChIP-Seq_K562_Human1.63445601
56STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.61802956
57SCL_19346495_ChIP-Seq_HPC-7_Human1.61424461
58STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.60842779
59CREB1_15753290_ChIP-ChIP_HEK293T_Human1.60275761
60RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.59914449
61VDR_21846776_ChIP-Seq_THP-1_Human1.58764271
62TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.58147567
63RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.57726940
64BRD4_27068464_Chip-Seq_AML-cells_Mouse1.56835239
65EZH2_27294783_Chip-Seq_NPCs_Mouse1.56066357
66MAF_26560356_Chip-Seq_TH1_Human1.54314756
67NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.53869371
68RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.52951635
69KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.52261818
70SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52013050
71DCP1A_22483619_ChIP-Seq_HELA_Human1.50202596
72CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.49609335
73MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.48865575
74NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.48451426
75KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.48345767
76FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.47051859
77TRIM28_21343339_ChIP-Seq_HEK293_Human1.46602477
78POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.46159719
79TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46159719
80SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.45745275
81ELK3_25401928_ChIP-Seq_HUVEC_Human1.45645016
82IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.45523360
83TCF7_22412390_ChIP-Seq_EML_Mouse1.45208757
84TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.44704506
85HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.44655976
86MYB_26560356_Chip-Seq_TH2_Human1.43327365
87EST1_17652178_ChIP-ChIP_JURKAT_Human1.43058837
88MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.40768877
89CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.40109013
90EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.39021504
91P300_19829295_ChIP-Seq_ESCs_Human1.38934608
92CDX2_19796622_ChIP-Seq_MESCs_Mouse1.38344623
93UTX_26944678_Chip-Seq_JUKART_Human1.35701419
94SOX2_27498859_Chip-Seq_STOMACH_Mouse1.34155429
95TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33332790
96E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.30345441
97TP53_22573176_ChIP-Seq_HFKS_Human1.30013163
98PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.29295678
99TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.29060699
100GATA4_25053715_ChIP-Seq_YYC3_Human1.27799186
101TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.26840037
102AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.25409320
103ER_23166858_ChIP-Seq_MCF-7_Human1.24923038
104FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.24656386
105FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.23889081
106CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.23641364
107WT1_19549856_ChIP-ChIP_CCG9911_Human1.23135264
108ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.22993399
109RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.22990564
110REST_19997604_ChIP-ChIP_NEURONS_Mouse1.22626525
111ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.22582248
112E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.22530648
113ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.22476767
114ATF3_27146783_Chip-Seq_COLON_Human1.22335551
115FOXO3_23340844_ChIP-Seq_DLD1_Human1.22298740
116TP63_19390658_ChIP-ChIP_HaCaT_Human1.22138940
117VDR_24763502_ChIP-Seq_THP-1_Human1.21940954
118IRF8_27001747_Chip-Seq_BMDM_Mouse1.21911451
119TBX20_22328084_ChIP-Seq_HEART_Mouse1.21092846
120TBX20_22080862_ChIP-Seq_HEART_Mouse1.21092846
121FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.20708429
122NANOG_21062744_ChIP-ChIP_HESCs_Human1.20475211
123TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.20161699
124CTBP2_25329375_ChIP-Seq_LNCAP_Human1.20071093
125GATA1_22383799_ChIP-Seq_G1ME_Mouse1.19667135
126SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.19602654
127PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.19047460
128SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.18485217
129CTBP1_25329375_ChIP-Seq_LNCAP_Human1.18365068
130MYB_26560356_Chip-Seq_TH1_Human1.17611166
131YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17180477
132POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.15868437
133FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.15376193
134RUNX1_22412390_ChIP-Seq_EML_Mouse1.14937156
135CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.14608871
136GATA2_22383799_ChIP-Seq_G1ME_Mouse1.13633570
137STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.13388766
138SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.13294757
139KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.13287339
140TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.13136478
141P63_26484246_Chip-Seq_KERATINOCYTES_Human1.12945117
142GATA6_25053715_ChIP-Seq_YYC3_Human1.12076622
143JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.11495618
144ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.11440953
145SALL1_21062744_ChIP-ChIP_HESCs_Human1.11200720
146SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.11149007
147KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.11054125
148TTF2_22483619_ChIP-Seq_HELA_Human1.10373102
149SPI1_23547873_ChIP-Seq_NB4_Human1.09654719
150SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.08681204
151MYCN_18555785_ChIP-Seq_MESCs_Mouse1.08525142
152CRX_20693478_ChIP-Seq_RETINA_Mouse1.08076639
153NFYB_21822215_ChIP-Seq_K562_Human1.07553920
154NANOG_18555785_Chip-Seq_ESCs_Mouse1.07165499
155ESR1_21235772_ChIP-Seq_MCF-7_Human1.06911008
156RACK7_27058665_Chip-Seq_MCF-7_Human1.06853595
157SOX2_20726797_ChIP-Seq_SW620_Human1.06732649
158CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06547586
159RUNX_20019798_ChIP-Seq_JUKART_Human1.06332013
160FOXA1_21572438_ChIP-Seq_LNCaP_Human1.06200031
161FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.05999041
162GATA2_21666600_ChIP-Seq_HMVEC_Human1.05777755
163NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.05460908
164BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.04508541
165KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.04272999
166KDM2B_26808549_Chip-Seq_DND41_Human1.04227038
167BMI1_23680149_ChIP-Seq_NPCS_Mouse1.04091400
168STAT4_19710469_ChIP-ChIP_TH1__Mouse1.03720946
169TFEB_21752829_ChIP-Seq_HELA_Human1.02896268
170LXR_22292898_ChIP-Seq_THP-1_Human1.02783301
171SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01546907
172GATA3_27048872_Chip-Seq_THYMUS_Human1.01221320
173TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.00932070
174EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00475827
175FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.00368658
176TAL1_26923725_Chip-Seq_HPCs_Mouse1.00131921
177IRF8_21731497_ChIP-ChIP_J774_Mouse1.00071801
178P53_22387025_ChIP-Seq_ESCs_Mouse0.99952734
179OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99352970
180E2F1_18555785_Chip-Seq_ESCs_Mouse0.99100231
181PCGF2_27294783_Chip-Seq_NPCs_Mouse0.98628616
182OCT4_21477851_ChIP-Seq_ESCs_Mouse0.98135964
183GABP_19822575_ChIP-Seq_HepG2_Human0.97957061
184NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97352009
185THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.97125437
186UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96780292
187HOXB4_20404135_ChIP-ChIP_EML_Mouse0.96664636
188TCF4_22108803_ChIP-Seq_LS180_Human0.96396160
189CBX2_27304074_Chip-Seq_ESCs_Mouse0.96152041
190ETS1_20019798_ChIP-Seq_JURKAT_Human0.96124270
191RNF2_27304074_Chip-Seq_NSC_Mouse0.95986347
192ERG_20887958_ChIP-Seq_HPC-7_Mouse0.95795973
193SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.95580156
194SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.95580156
195NFE2_27457419_Chip-Seq_LIVER_Mouse0.95080203
196FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.94925845
197HIF1A_21447827_ChIP-Seq_MCF-7_Human0.94518099
198ZFX_18555785_ChIP-Seq_MESCs_Mouse0.93774591
199PCGF2_27294783_Chip-Seq_ESCs_Mouse0.93543252

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002009_preneoplasia8.96581348
2MP0002653_abnormal_ependyma_morphology4.87336874
3MP0001529_abnormal_vocalization3.32512542
4MP0005360_urolithiasis3.11204945
5MP0002139_abnormal_hepatobiliary_system3.06081638
6MP0004043_abnormal_pH_regulation3.04159370
7MP0002234_abnormal_pharynx_morphology2.94093623
8MP0005365_abnormal_bile_salt2.69768213
9MP0003705_abnormal_hypodermis_morpholog2.34457834
10MP0005085_abnormal_gallbladder_physiolo2.32447970
11MP0003300_gastrointestinal_ulcer2.25712445
12MP0006054_spinal_hemorrhage2.12723223
13MP0003252_abnormal_bile_duct2.07572008
14MP0002877_abnormal_melanocyte_morpholog2.06705664
15MP0005187_abnormal_penis_morphology2.04766396
16MP0008438_abnormal_cutaneous_collagen2.02951370
17MP0001299_abnormal_eye_distance/1.96343463
18MP0005645_abnormal_hypothalamus_physiol1.92773360
19MP0002837_dystrophic_cardiac_calcinosis1.90591558
20MP0001764_abnormal_homeostasis1.89366275
21MP0003693_abnormal_embryo_hatching1.88999919
22MP0000427_abnormal_hair_cycle1.88246438
23MP0002138_abnormal_hepatobiliary_system1.87806142
24MP0000516_abnormal_urinary_system1.83569042
25MP0005367_renal/urinary_system_phenotyp1.83569042
26MP0010094_abnormal_chromosome_stability1.77265661
27MP0005275_abnormal_skin_tensile1.76074782
28MP0003880_abnormal_central_pattern1.75547038
29MP0001666_abnormal_nutrient_absorption1.72682639
30MP0001293_anophthalmia1.72588493
31MP0008875_abnormal_xenobiotic_pharmacok1.72077882
32MP0003806_abnormal_nucleotide_metabolis1.66815926
33MP0008789_abnormal_olfactory_epithelium1.63852731
34MP0002938_white_spotting1.62336986
35MP0009840_abnormal_foam_cell1.59774647
36MP0000685_abnormal_immune_system1.58801881
37MP0002166_altered_tumor_susceptibility1.57071191
38MP0003315_abnormal_perineum_morphology1.55637647
39MP0005253_abnormal_eye_physiology1.53340174
40MP0010234_abnormal_vibrissa_follicle1.47959380
41MP0001727_abnormal_embryo_implantation1.47064635
42MP0003566_abnormal_cell_adhesion1.46003439
43MP0003195_calcinosis1.45780207
44MP0004130_abnormal_muscle_cell1.44319087
45MP0010329_abnormal_lipoprotein_level1.42399376
46MP0001835_abnormal_antigen_presentation1.40707603
47MP0004947_skin_inflammation1.35519697
48MP0004084_abnormal_cardiac_muscle1.35004045
49MP0002233_abnormal_nose_morphology1.33626437
50MP0005083_abnormal_biliary_tract1.32739441
51MP0009643_abnormal_urine_homeostasis1.32170731
52MP0003436_decreased_susceptibility_to1.31948283
53MP0003191_abnormal_cellular_cholesterol1.31607648
54MP0000609_abnormal_liver_physiology1.29789880
55MP0000647_abnormal_sebaceous_gland1.29754807
56MP0005220_abnormal_exocrine_pancreas1.29136647
57MP0002971_abnormal_brown_adipose1.28073109
58MP0010352_gastrointestinal_tract_polyps1.27901994
59MP0002102_abnormal_ear_morphology1.27470648
60MP0002095_abnormal_skin_pigmentation1.27112004
61MP0003646_muscle_fatigue1.26590204
62MP0004185_abnormal_adipocyte_glucose1.23658091
63MP0005058_abnormal_lysosome_morphology1.21397528
64MP0003724_increased_susceptibility_to1.20900080
65MP0005319_abnormal_enzyme/_coenzyme1.20823394
66MP0005464_abnormal_platelet_physiology1.20802864
67MP0006036_abnormal_mitochondrial_physio1.18774541
68MP0005666_abnormal_adipose_tissue1.17133266
69MP0010368_abnormal_lymphatic_system1.16860201
70MP0004147_increased_porphyrin_level1.14809099
71MP0005332_abnormal_amino_acid1.14429868
72MP0003656_abnormal_erythrocyte_physiolo1.13484878
73MP0004484_altered_response_of1.12535217
74MP0006072_abnormal_retinal_apoptosis1.11600246
75MP0010155_abnormal_intestine_physiology1.11219715
76MP0003941_abnormal_skin_development1.11197175
77MP0001873_stomach_inflammation1.10413945
78MP0002060_abnormal_skin_morphology1.10412221
79MP0002160_abnormal_reproductive_system1.10211360
80MP0001984_abnormal_olfaction1.09651887
81MP0005248_abnormal_Harderian_gland1.09486434
82MP0003183_abnormal_peptide_metabolism1.07630069
83MP0001346_abnormal_lacrimal_gland1.05532847
84MP0010630_abnormal_cardiac_muscle1.05175690
85MP0009384_cardiac_valve_regurgitation1.02477201
86MP0003221_abnormal_cardiomyocyte_apopto1.01814817
87MP0005330_cardiomyopathy1.01763481
88MP0009785_altered_susceptibility_to1.01388010
89MP0005023_abnormal_wound_healing1.00370997
90MP0000490_abnormal_crypts_of0.99505097
91MP0000604_amyloidosis0.99166625
92MP0002118_abnormal_lipid_homeostasis0.99145424
93MP0006035_abnormal_mitochondrial_morpho0.98853529
94MP0005387_immune_system_phenotype0.98841645
95MP0001790_abnormal_immune_system0.98841645
96MP0002909_abnormal_adrenal_gland0.98124588
97MP0002006_tumorigenesis0.97073630
98MP0004087_abnormal_muscle_fiber0.96034634
99MP0003111_abnormal_nucleus_morphology0.95936484
100MP0002132_abnormal_respiratory_system0.94812258
101MP0009697_abnormal_copulation0.94449585
102MP0004924_abnormal_behavior0.94391897
103MP0005386_behavior/neurological_phenoty0.94391897
104MP0008469_abnormal_protein_level0.94045207
105MP0006276_abnormal_autonomic_nervous0.93462152
106MP0003279_aneurysm0.93158390
107MP0003186_abnormal_redox_activity0.93102820
108MP0001845_abnormal_inflammatory_respons0.92877859
109MP0003283_abnormal_digestive_organ0.92869988
110MP0005391_vision/eye_phenotype0.92855310
111MP0000013_abnormal_adipose_tissue0.92153993
112MP0005025_abnormal_response_to0.92088375
113MP0001533_abnormal_skeleton_physiology0.92055664
114MP0001958_emphysema0.91694571
115MP0001340_abnormal_eyelid_morphology0.91345614
116MP0000598_abnormal_liver_morphology0.90970935
117MP0004133_heterotaxia0.89909912
118MP0004036_abnormal_muscle_relaxation0.89430822
119MP0002933_joint_inflammation0.88673661
120MP0002254_reproductive_system_inflammat0.88503027
121MP0001944_abnormal_pancreas_morphology0.87720198
122MP0001800_abnormal_humoral_immune0.87263007
123MP0003763_abnormal_thymus_physiology0.87104488
124MP0002269_muscular_atrophy0.87071934
125MP0005385_cardiovascular_system_phenoty0.86268071
126MP0001544_abnormal_cardiovascular_syste0.86268071
127MP0003303_peritoneal_inflammation0.86218904
128MP0001243_abnormal_dermal_layer0.85403775
129MP0005375_adipose_tissue_phenotype0.85390585
130MP0005499_abnormal_olfactory_system0.84951777
131MP0005394_taste/olfaction_phenotype0.84951777
132MP0001270_distended_abdomen0.84608521
133MP0000462_abnormal_digestive_system0.84056037
134MP0003868_abnormal_feces_composition0.83005760
135MP0003937_abnormal_limbs/digits/tail_de0.82867905
136MP0002090_abnormal_vision0.82859927
137MP0003828_pulmonary_edema0.82782710
138MP0003453_abnormal_keratinocyte_physiol0.82235002
139MP0003567_abnormal_fetal_cardiomyocyte0.81283038
140MP0002452_abnormal_antigen_presenting0.80688656
141MP0000465_gastrointestinal_hemorrhage0.80261358
142MP0002693_abnormal_pancreas_physiology0.79752862
143MP0002396_abnormal_hematopoietic_system0.79597028
144MP0005000_abnormal_immune_tolerance0.79433000
145MP0000631_abnormal_neuroendocrine_gland0.79212907
146MP0003121_genomic_imprinting0.79189744
147MP0004264_abnormal_extraembryonic_tissu0.79149612
148MP0000343_altered_response_to0.78165883
149MP0005584_abnormal_enzyme/coenzyme_acti0.77960289
150MP0005671_abnormal_response_to0.77640439
151MP0000749_muscle_degeneration0.77564913
152MP0002419_abnormal_innate_immunity0.77540829
153MP0005076_abnormal_cell_differentiation0.77006765
154MP0009053_abnormal_anal_canal0.76487226
155MP0009763_increased_sensitivity_to0.75850971
156MP0002078_abnormal_glucose_homeostasis0.75469556
157MP0002972_abnormal_cardiac_muscle0.75330648
158MP0005084_abnormal_gallbladder_morpholo0.74373693
159MP0002723_abnormal_immune_serum0.74176990
160MP0003786_premature_aging0.74092863
161MP0008058_abnormal_DNA_repair0.74008210
162MP0000750_abnormal_muscle_regeneration0.73782839
163MP0001879_abnormal_lymphatic_vessel0.73113780
164MP0004215_abnormal_myocardial_fiber0.71551350
165MP0000015_abnormal_ear_pigmentation0.71296959
166MP0004811_abnormal_neuron_physiology0.69857919
167MP0005551_abnormal_eye_electrophysiolog0.69638723
168MP0000377_abnormal_hair_follicle0.66240165
169MP0002177_abnormal_outer_ear0.65925714
170MP0004197_abnormal_fetal_growth/weight/0.65485456
171MP0002092_abnormal_eye_morphology0.64981934
172MP0008995_early_reproductive_senescence0.64058983
173MP0000778_abnormal_nervous_system0.63168731
174MP0001186_pigmentation_phenotype0.62860802
175MP0000653_abnormal_sex_gland0.62542629
176MP0001119_abnormal_female_reproductive0.61924449
177MP0001145_abnormal_male_reproductive0.61788376
178MP0002970_abnormal_white_adipose0.61609848
179MP0004142_abnormal_muscle_tone0.61425036
180MP0002751_abnormal_autonomic_nervous0.60081102
181MP0002752_abnormal_somatic_nervous0.59898255
182MP0008932_abnormal_embryonic_tissue0.59222378
183MP0005389_reproductive_system_phenotype0.58856985
184MP0001188_hyperpigmentation0.58101228
185MP0002075_abnormal_coat/hair_pigmentati0.57593041
186MP0000751_myopathy0.56877888
187MP0005195_abnormal_posterior_eye0.56168617
188MP0000383_abnormal_hair_follicle0.55723831
189MP0005535_abnormal_body_temperature0.55602130

Predicted human phenotypes

RankGene SetZ-score
1Pheochromocytoma (HP:0002666)7.38316087
2Neuroendocrine neoplasm (HP:0100634)6.68554939
3Mutism (HP:0002300)5.98558904
4Abnormality of pyruvate family amino acid metabolism (HP:0010915)5.44668946
5Abnormality of alanine metabolism (HP:0010916)5.44668946
6Hyperalaninemia (HP:0003348)5.44668946
7Pancreatic islet-cell hyperplasia (HP:0004510)4.61180071
8Confusion (HP:0001289)4.31233553
9Hypoglycemic coma (HP:0001325)4.26277902
10Inability to walk (HP:0002540)4.00703090
11Morphological abnormality of the pyramidal tract (HP:0002062)3.89885681
12Abnormality of aromatic amino acid family metabolism (HP:0004338)3.68056126
13Cerebral hemorrhage (HP:0001342)3.60360585
14Pancreatic cysts (HP:0001737)3.51813366
15Neoplasm of the peripheral nervous system (HP:0100007)3.42025789
16B lymphocytopenia (HP:0010976)3.41793729
17Capillary hemangiomas (HP:0005306)3.26267229
18Ketoacidosis (HP:0001993)3.18877463
19Right ventricular cardiomyopathy (HP:0011663)3.13401936
20Abnormality of B cell number (HP:0010975)2.96744266
21Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.93307615
22Deep venous thrombosis (HP:0002625)2.92948441
23Fatigue (HP:0012378)2.90590087
24Asymmetric septal hypertrophy (HP:0001670)2.89284388
25Increased serum pyruvate (HP:0003542)2.88923190
26Abnormality of fatty-acid metabolism (HP:0004359)2.87432610
27Ketosis (HP:0001946)2.87430510
28Tinnitus (HP:0000360)2.86573020
29Xanthomatosis (HP:0000991)2.80796160
30Myoglobinuria (HP:0002913)2.78703001
31Cystic hygroma (HP:0000476)2.77939909
32Congenital primary aphakia (HP:0007707)2.75980005
33Asymmetry of the thorax (HP:0001555)2.75483247
34Nonimmune hydrops fetalis (HP:0001790)2.73710060
35Gait imbalance (HP:0002141)2.70648836
36Poor coordination (HP:0002370)2.67257848
37Intrahepatic cholestasis (HP:0001406)2.65912618
38Thyroid carcinoma (HP:0002890)2.64634125
39Medial flaring of the eyebrow (HP:0010747)2.62680036
40Generalized aminoaciduria (HP:0002909)2.62627082
41Hypoplasia of the thymus (HP:0000778)2.60785094
42Abnormal lung lobation (HP:0002101)2.60343901
43Abnormality of the columella (HP:0009929)2.58012685
44Ventricular tachycardia (HP:0004756)2.56954979
45Severe combined immunodeficiency (HP:0004430)2.53622299
46Paraparesis (HP:0002385)2.51828661
47Unilateral renal agenesis (HP:0000122)2.51804043
48Abnormality of the common coagulation pathway (HP:0010990)2.51472592
49Hyperammonemia (HP:0001987)2.51271509
50Protrusio acetabuli (HP:0003179)2.50638599
51Late onset (HP:0003584)2.50577873
52Vaginal atresia (HP:0000148)2.50313889
53Cutaneous melanoma (HP:0012056)2.50188106
54Genital tract atresia (HP:0001827)2.49794424
55Abnormality of the 4th metacarpal (HP:0010012)2.48172953
56Hypoglycemic seizures (HP:0002173)2.47760808
57Barrel-shaped chest (HP:0001552)2.46213808
58Conjunctival hamartoma (HP:0100780)2.44704550
59Nephrogenic diabetes insipidus (HP:0009806)2.44625579
60Abnormality of glutamine family amino acid metabolism (HP:0010902)2.43337102
61Thyroiditis (HP:0100646)2.43231639
62Panhypogammaglobulinemia (HP:0003139)2.42899542
63Abnormality of monocarboxylic acid metabolism (HP:0010996)2.42885710
64Long clavicles (HP:0000890)2.41725679
65Rhabdomyolysis (HP:0003201)2.39831407
66High anterior hairline (HP:0009890)2.38318781
67Lower limb hyperreflexia (HP:0002395)2.38094073
68Toxemia of pregnancy (HP:0100603)2.36260989
69Hyperglycemia (HP:0003074)2.33069656
70Urinary glycosaminoglycan excretion (HP:0003541)2.31502533
71Mucopolysacchariduria (HP:0008155)2.31502533
72Absent eyebrow (HP:0002223)2.31499489
73Bundle branch block (HP:0011710)2.31109684
74Abnormal protein glycosylation (HP:0012346)2.30394858
75Abnormal glycosylation (HP:0012345)2.30394858
76Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.30394858
77Abnormal protein N-linked glycosylation (HP:0012347)2.30394858
78Abnormality of dicarboxylic acid metabolism (HP:0010995)2.28019748
79Dicarboxylic aciduria (HP:0003215)2.28019748
80Abnormality of the intrinsic pathway (HP:0010989)2.26969743
81Postaxial foot polydactyly (HP:0001830)2.24628229
82Abnormality of glycolysis (HP:0004366)2.24543476
83Peritonitis (HP:0002586)2.22393029
84Type I transferrin isoform profile (HP:0003642)2.21241411
85Hyperinsulinemic hypoglycemia (HP:0000825)2.19428752
86Thrombocytosis (HP:0001894)2.17583466
87Hypobetalipoproteinemia (HP:0003563)2.17375213
88Absent rod-and cone-mediated responses on ERG (HP:0007688)2.16282522
89Spinal cord lesions (HP:0100561)2.11920758
90Syringomyelia (HP:0003396)2.11920758
91Polycythemia (HP:0001901)2.10564133
92Abnormality of male internal genitalia (HP:0000022)2.09044051
93Type 1 muscle fiber predominance (HP:0003803)2.08287512
94Palpitations (HP:0001962)2.07805838
95Hydroxyprolinuria (HP:0003080)2.06345181
96Abnormality of proline metabolism (HP:0010907)2.06345181
97Exercise-induced muscle cramps (HP:0003710)2.04714216
98Abnormality of mucopolysaccharide metabolism (HP:0011020)2.04191418
99Abnormality of polysaccharide metabolism (HP:0011012)2.04191418
100Abnormality of glycosaminoglycan metabolism (HP:0004371)2.04191418
101Myocardial infarction (HP:0001658)2.03997833
102Lipoatrophy (HP:0100578)2.01443999
103Hyporeflexia of lower limbs (HP:0002600)2.00994610
104Benign neoplasm of the central nervous system (HP:0100835)2.00257788
105External ophthalmoplegia (HP:0000544)1.99806678
106Median cleft lip (HP:0000161)1.99030702
107Short tibia (HP:0005736)1.96977731
108Increased connective tissue (HP:0009025)1.95953587
109Cortical dysplasia (HP:0002539)1.95301802
110Combined immunodeficiency (HP:0005387)1.95106647
111Abnormality of the phalanges of the hallux (HP:0010057)1.95048218
112Thin bony cortex (HP:0002753)1.94829101
113Hypoproteinemia (HP:0003075)1.94365306
114Postaxial hand polydactyly (HP:0001162)1.94252908
115Partial agenesis of the corpus callosum (HP:0001338)1.93733708
116Insulin resistance (HP:0000855)1.90044028
117Abnormality of the pancreatic islet cells (HP:0006476)1.88985295
118Abnormality of endocrine pancreas physiology (HP:0012093)1.88985295
119Pendular nystagmus (HP:0012043)1.88910398
120Hypolipoproteinemia (HP:0010981)1.88826383
121Exercise-induced myalgia (HP:0003738)1.88200342
122Dysostosis multiplex (HP:0000943)1.87915796
123Dilated cardiomyopathy (HP:0001644)1.86211830
124Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.86077489
125Short 4th metacarpal (HP:0010044)1.86077489
126Abnormality of purine metabolism (HP:0004352)1.85817109
127Increased muscle lipid content (HP:0009058)1.85716202
128Spontaneous hematomas (HP:0007420)1.84365187
129Fat malabsorption (HP:0002630)1.83329264
130Abnormality of homocysteine metabolism (HP:0010919)1.82579638
131Homocystinuria (HP:0002156)1.82579638
132Prolonged partial thromboplastin time (HP:0003645)1.81637080
133Broad foot (HP:0001769)1.81434344
134Limb-girdle muscle atrophy (HP:0003797)1.80770823
135Complement deficiency (HP:0004431)1.80659621
136Hematochezia (HP:0002573)1.80246358
137Hypoalphalipoproteinemia (HP:0003233)1.79770911
138Ulnar deviation of the wrist (HP:0003049)1.78073523
139Deep philtrum (HP:0002002)1.76691194
140Abnormal cartilage morphology (HP:0002763)1.76643907
141True hermaphroditism (HP:0010459)1.76311589
142Symptomatic seizures (HP:0011145)1.76098467
143Sudden death (HP:0001699)1.75790242
144Abnormality of transition element cation homeostasis (HP:0011030)1.75723230
145Failure to thrive in infancy (HP:0001531)1.75690742
146Nemaline bodies (HP:0003798)1.75671274
147Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.75608030
148Muscle fiber inclusion bodies (HP:0100299)1.75541203
149Bicornuate uterus (HP:0000813)1.75082996
150Aortic aneurysm (HP:0004942)1.74970250
151Aplasia/Hypoplasia of the tibia (HP:0005772)1.74435993
152Hyperbilirubinemia (HP:0002904)1.74068449
153Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.73782483
154Abnormal foot bone ossification (HP:0010675)1.73226489
155Hepatocellular carcinoma (HP:0001402)1.71904606
156Pseudobulbar signs (HP:0002200)1.70992397
157Arterial thrombosis (HP:0004420)1.70842991
158Lymphangioma (HP:0100764)1.70442718
159Dental crowding (HP:0000678)1.70429191
160Hyperlipoproteinemia (HP:0010980)1.70049700
161Joint hemorrhage (HP:0005261)1.69894002
162Specific learning disability (HP:0001328)1.69773580
163Gastrointestinal inflammation (HP:0004386)1.69230925
164Vertebral compression fractures (HP:0002953)1.69202984
165Skin nodule (HP:0200036)1.69125671
166Metabolic acidosis (HP:0001942)1.68854104
167Abnormal platelet function (HP:0011869)1.68517140
168Impaired platelet aggregation (HP:0003540)1.68517140
169Chronic otitis media (HP:0000389)1.68447579
170Abnormality of the nasal mucosa (HP:0000433)1.68108966
171Abnormality of iron homeostasis (HP:0011031)1.68107520
172Ankle contracture (HP:0006466)1.67696844
173Cervical subluxation (HP:0003308)1.67643158
174Abnormal biliary tract morphology (HP:0012440)1.66825042
175Gingival bleeding (HP:0000225)1.66701087
176Abdominal distention (HP:0003270)1.65431032
177Epidermoid cyst (HP:0200040)1.65353698
178Subaortic stenosis (HP:0001682)1.65313292
179Abnormality of the left ventricular outflow tract (HP:0011103)1.65313292
180Papillary thyroid carcinoma (HP:0002895)1.65180145
181Limb hypertonia (HP:0002509)1.64074082
182Neonatal death (HP:0003811)1.63641298
183Premature rupture of membranes (HP:0001788)1.62812626
184Abnormal platelet volume (HP:0011876)1.62789069
185Ragged-red muscle fibers (HP:0003200)1.61353277
186Esophageal varix (HP:0002040)1.61096179
187Thrombophlebitis (HP:0004418)1.59739174
188Aneurysm (HP:0002617)1.59235606

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.86881288
2EIF2AK35.19359571
3TRIB34.27846900
4PKN23.54109121
5ERN13.43770474
6WEE12.87361612
7YES12.84283652
8TTN2.65724848
9FLT32.61737871
10FGFR42.44162393
11EIF2AK22.34433883
12EEF2K2.11636039
13BCKDK2.07163007
14PTK61.96085533
15MAP3K31.95463436
16MAP3K101.90876832
17CCNB11.90086466
18TYK21.85904219
19LRRK21.83188121
20MAP4K11.80183057
21CLK11.79261770
22JAK31.77985321
23TBK11.74190867
24BCR1.70589922
25VRK11.65817063
26MAPKAPK31.64803046
27KIT1.64590638
28BUB11.61102529
29TAF11.58690406
30SIK11.57484774
31RIPK11.54701362
32CAMK41.49870266
33TAOK31.47065336
34CASK1.44352114
35MAP3K41.43778729
36TGFBR21.41761842
37SRPK11.40720949
38TGFBR11.40226569
39PIK3CG1.38440701
40ZAP701.38317055
41FRK1.37784821
42DMPK1.37193610
43INSRR1.34263084
44MAP2K31.33342353
45PDGFRA1.31220454
46MAP2K71.30692042
47CSNK1G21.28876359
48CSNK1G31.26800931
49MAPK151.22712961
50DYRK31.22309639
51TRIM281.20973165
52NUAK11.18971295
53STK38L1.18159318
54BTK1.17657985
55CSNK1A1L1.17545701
56UHMK11.16510830
57NEK21.16485677
58FGFR31.15528922
59NEK91.15081785
60EPHB11.14817151
61EPHA31.13821174
62PHKG11.12931132
63PHKG21.12931132
64ILK1.12367494
65NME21.12119196
66ITK1.11607490
67JAK11.11278814
68CHEK21.10023449
69BMPR1B1.09857285
70STK101.09001209
71DYRK1B1.07777753
72RPS6KA41.06073501
73CSNK1G11.05226821
74PASK1.05124037
75MAP4K20.97971736
76TRPM70.96682523
77LMTK20.96427502
78SCYL20.95517559
79ACVR1B0.94975703
80PINK10.91769850
81RPS6KC10.91287551
82RPS6KL10.91287551
83MAP3K20.90495661
84TEC0.88380219
85IKBKE0.88004551
86RPS6KA60.87317505
87KDR0.85772422
88MYLK0.85602356
89STK240.85536517
90JAK20.83961693
91PLK40.83746162
92CSF1R0.83348375
93WNK30.83149082
94MAPK110.82494828
95MAP2K20.81707185
96STK390.80480578
97MAPK130.76617405
98PRKG20.76327007
99CDK60.73342120
100PTK20.72123185
101BLK0.72041238
102MST1R0.70571436
103PIM20.69452334
104PAK40.67328044
105TESK10.67146261
106HIPK20.66574563
107OBSCN0.66258949
108CAMK10.66087609
109MAP3K110.65473233
110TYRO30.64424322
111RPS6KB20.63927475
112SGK20.63431229
113RET0.62862863
114CHUK0.62052087
115MAPKAPK50.61648799
116GRK10.61024565
117MST40.59252284
118MAP3K10.58753157
119LATS10.58044330
120PRKD10.57682044
121ERBB30.57135077
122CSK0.56560348
123SYK0.55692997
124MET0.55578121
125BRD40.54397892
126CDK190.53827047
127LIMK10.52989349
128PIM10.51735143
129WNK40.51601384
130MAPKAPK20.51203551
131CAMKK20.50766573
132NLK0.50456857
133EGFR0.50370958
134PIK3CA0.50075824
135MAP3K80.49810166
136IKBKB0.49411116
137PDGFRB0.49121378
138MAP2K40.48131313
139TIE10.47725472
140ATR0.47657024
141PAK30.47615363
142EPHB20.47200631
143MARK10.46054478
144CDK70.45676538
145AKT30.44448479
146PRKCE0.43835304
147MAP3K50.42988956
148MAP2K10.42482822
149BMPR20.42477507
150PAK20.39849920
151SGK2230.39675559
152SGK4940.39675559
153CSNK1A10.39501711
154PRKCZ0.38690674
155MUSK0.38338341
156MTOR0.37185124
157TAOK10.36738149
158CAMK2A0.36734901
159STK30.36173298
160LCK0.36136586
161HCK0.35214273
162IRAK40.34883074
163PRKAA20.34846998
164LYN0.34583386
165FER0.34222143
166RPS6KA50.33763222
167PRKCH0.31972119
168PLK20.29173750
169ERBB20.28894284
170ABL10.27574486
171ADRBK20.24044916
172MKNK10.23919988
173CDK140.23361150
174CDK180.19964576
175CDK30.18933799
176CSNK1D0.18805666
177GRK50.18135327
178IGF1R0.17213134
179RPS6KB10.16545852

Predicted pathways (KEGG)

RankGene SetZ-score
1Taurine and hypotaurine metabolism_Homo sapiens_hsa004304.17861222
2Vitamin digestion and absorption_Homo sapiens_hsa049773.24781091
3Fatty acid degradation_Homo sapiens_hsa000712.96603854
4RNA degradation_Homo sapiens_hsa030182.70170935
5DNA replication_Homo sapiens_hsa030302.66103521
6Maturity onset diabetes of the young_Homo sapiens_hsa049502.57537655
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.56943973
8Nucleotide excision repair_Homo sapiens_hsa034202.53727297
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.50127774
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.42163347
11Non-homologous end-joining_Homo sapiens_hsa034502.38001055
12Basal transcription factors_Homo sapiens_hsa030222.31009107
13Primary bile acid biosynthesis_Homo sapiens_hsa001202.26130148
14Homologous recombination_Homo sapiens_hsa034402.21601794
15Tryptophan metabolism_Homo sapiens_hsa003802.18806781
16Caffeine metabolism_Homo sapiens_hsa002322.15413444
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.08971037
18Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.04571083
19Mismatch repair_Homo sapiens_hsa034302.04054339
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.96663453
21Pyrimidine metabolism_Homo sapiens_hsa002401.95660614
22Sulfur metabolism_Homo sapiens_hsa009201.93880174
23Propanoate metabolism_Homo sapiens_hsa006401.80096259
24Pentose and glucuronate interconversions_Homo sapiens_hsa000401.79061425
25Folate biosynthesis_Homo sapiens_hsa007901.77244611
26Fatty acid metabolism_Homo sapiens_hsa012121.73801854
27Nitrogen metabolism_Homo sapiens_hsa009101.72473949
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.67778789
29Selenocompound metabolism_Homo sapiens_hsa004501.67243140
30Fanconi anemia pathway_Homo sapiens_hsa034601.62007164
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.59817024
32Starch and sucrose metabolism_Homo sapiens_hsa005001.57134302
33PPAR signaling pathway_Homo sapiens_hsa033201.51011456
34Circadian rhythm_Homo sapiens_hsa047101.45841580
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.45247596
36RNA polymerase_Homo sapiens_hsa030201.44220340
37Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.43465476
38Peroxisome_Homo sapiens_hsa041461.41165500
39Complement and coagulation cascades_Homo sapiens_hsa046101.39137762
40Fat digestion and absorption_Homo sapiens_hsa049751.37686685
41p53 signaling pathway_Homo sapiens_hsa041151.37198950
42Arginine biosynthesis_Homo sapiens_hsa002201.35138213
43Butanoate metabolism_Homo sapiens_hsa006501.33918407
44Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.33572704
45Carbon metabolism_Homo sapiens_hsa012001.28404778
46Purine metabolism_Homo sapiens_hsa002301.28072259
47Staphylococcus aureus infection_Homo sapiens_hsa051501.27883170
48Histidine metabolism_Homo sapiens_hsa003401.27104225
49Regulation of autophagy_Homo sapiens_hsa041401.23242387
50beta-Alanine metabolism_Homo sapiens_hsa004101.20639684
51Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.16120825
52Base excision repair_Homo sapiens_hsa034101.09781761
53Pyruvate metabolism_Homo sapiens_hsa006201.07543973
54Renal cell carcinoma_Homo sapiens_hsa052111.07502125
55Insulin resistance_Homo sapiens_hsa049311.06166994
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.05746756
57Leishmaniasis_Homo sapiens_hsa051401.05035571
58Spliceosome_Homo sapiens_hsa030401.04328403
59Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.01404862
60Lysine degradation_Homo sapiens_hsa003100.99892999
61RNA transport_Homo sapiens_hsa030130.99830587
62Galactose metabolism_Homo sapiens_hsa000520.94277137
63Drug metabolism - other enzymes_Homo sapiens_hsa009830.90412169
64Chemical carcinogenesis_Homo sapiens_hsa052040.90403094
65Glycosaminoglycan degradation_Homo sapiens_hsa005310.90133587
66Protein export_Homo sapiens_hsa030600.89152193
67Viral myocarditis_Homo sapiens_hsa054160.87707312
68Antigen processing and presentation_Homo sapiens_hsa046120.86856438
69mRNA surveillance pathway_Homo sapiens_hsa030150.84395171
70Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.83898387
71Legionellosis_Homo sapiens_hsa051340.83790464
72Phenylalanine metabolism_Homo sapiens_hsa003600.82872751
73Phototransduction_Homo sapiens_hsa047440.82695633
74Toxoplasmosis_Homo sapiens_hsa051450.80293039
75Vibrio cholerae infection_Homo sapiens_hsa051100.80147639
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.80092336
77Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.79663829
78Cell cycle_Homo sapiens_hsa041100.78445390
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.77783722
80Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.77148446
81One carbon pool by folate_Homo sapiens_hsa006700.77076784
82ABC transporters_Homo sapiens_hsa020100.75525523
83Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.74795299
84FoxO signaling pathway_Homo sapiens_hsa040680.73823330
85Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.73347594
86Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73196558
87Parkinsons disease_Homo sapiens_hsa050120.73031292
88Steroid biosynthesis_Homo sapiens_hsa001000.72162583
89Retinol metabolism_Homo sapiens_hsa008300.72010846
90Biosynthesis of amino acids_Homo sapiens_hsa012300.71610290
91Oocyte meiosis_Homo sapiens_hsa041140.71074921
92Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.71040044
93Leukocyte transendothelial migration_Homo sapiens_hsa046700.70602816
94Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.70004436
95Chronic myeloid leukemia_Homo sapiens_hsa052200.69890679
96Oxidative phosphorylation_Homo sapiens_hsa001900.69724835
97Osteoclast differentiation_Homo sapiens_hsa043800.67917920
98Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.65835789
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.64518338
100Pancreatic cancer_Homo sapiens_hsa052120.64358463
101Thyroid cancer_Homo sapiens_hsa052160.64093133
102Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62762308
103Long-term depression_Homo sapiens_hsa047300.61973605
104B cell receptor signaling pathway_Homo sapiens_hsa046620.61569750
105Jak-STAT signaling pathway_Homo sapiens_hsa046300.61450652
106Small cell lung cancer_Homo sapiens_hsa052220.60918189
107Primary immunodeficiency_Homo sapiens_hsa053400.60082559
108Focal adhesion_Homo sapiens_hsa045100.57512097
109Sulfur relay system_Homo sapiens_hsa041220.57240025
110Platelet activation_Homo sapiens_hsa046110.56980344
111Fatty acid elongation_Homo sapiens_hsa000620.56941582
112Metabolic pathways_Homo sapiens_hsa011000.55722813
113ErbB signaling pathway_Homo sapiens_hsa040120.55689887
114Bile secretion_Homo sapiens_hsa049760.55662150
115Pertussis_Homo sapiens_hsa051330.55328414
116Toll-like receptor signaling pathway_Homo sapiens_hsa046200.55095595
117Hedgehog signaling pathway_Homo sapiens_hsa043400.54647378
118Lysosome_Homo sapiens_hsa041420.54387861
119Steroid hormone biosynthesis_Homo sapiens_hsa001400.53163706
120Bladder cancer_Homo sapiens_hsa052190.52688083
121Shigellosis_Homo sapiens_hsa051310.52442071
122Huntingtons disease_Homo sapiens_hsa050160.51927459
123Acute myeloid leukemia_Homo sapiens_hsa052210.51598710
124N-Glycan biosynthesis_Homo sapiens_hsa005100.51402477
125Apoptosis_Homo sapiens_hsa042100.51305047
126Glutathione metabolism_Homo sapiens_hsa004800.51129392
127Measles_Homo sapiens_hsa051620.50881560
128Arginine and proline metabolism_Homo sapiens_hsa003300.50509547
129Pentose phosphate pathway_Homo sapiens_hsa000300.50337955
130Other glycan degradation_Homo sapiens_hsa005110.50041635
131Cardiac muscle contraction_Homo sapiens_hsa042600.49987054
132Renin-angiotensin system_Homo sapiens_hsa046140.49806932
133Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.49278138
134AMPK signaling pathway_Homo sapiens_hsa041520.48689499
135Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48329773
136Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.47556974
137Amoebiasis_Homo sapiens_hsa051460.46783326
138Insulin signaling pathway_Homo sapiens_hsa049100.46133445
139Proteoglycans in cancer_Homo sapiens_hsa052050.45796203
140Axon guidance_Homo sapiens_hsa043600.45684779
141ECM-receptor interaction_Homo sapiens_hsa045120.45138256
142Hippo signaling pathway_Homo sapiens_hsa043900.44967725
143TGF-beta signaling pathway_Homo sapiens_hsa043500.44949018
144RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.44517866
145Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.44332220
146Prolactin signaling pathway_Homo sapiens_hsa049170.43465032
147NF-kappa B signaling pathway_Homo sapiens_hsa040640.43188236
148Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42976447
149Alzheimers disease_Homo sapiens_hsa050100.41315130
150Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.40634081
151Dopaminergic synapse_Homo sapiens_hsa047280.38695601
152Sphingolipid signaling pathway_Homo sapiens_hsa040710.38060663
153Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37748055
154Sphingolipid metabolism_Homo sapiens_hsa006000.34986775
155Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34296578
156Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31461452
157Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.31299920
158Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.23992410
159Choline metabolism in cancer_Homo sapiens_hsa052310.23524628
160SNARE interactions in vesicular transport_Homo sapiens_hsa041300.23331263
161Viral carcinogenesis_Homo sapiens_hsa052030.21411819
162Thyroid hormone signaling pathway_Homo sapiens_hsa049190.20910073
163Melanoma_Homo sapiens_hsa052180.20035592
164Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.19994745
165GABAergic synapse_Homo sapiens_hsa047270.19089665

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