MICB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.85502528
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.79459589
3response to peptidoglycan (GO:0032494)3.65241896
4positive regulation of gamma-delta T cell activation (GO:0046645)3.64264251
5antigen processing and presentation of endogenous antigen (GO:0019883)3.49335297
6positive regulation by symbiont of host defense response (GO:0052509)3.45450850
7modulation by symbiont of host defense response (GO:0052031)3.45450850
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.45450850
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.45450850
10positive regulation by organism of defense response of other organism involved in symbiotic interact3.45450850
11modulation by symbiont of host immune response (GO:0052553)3.45450850
12type I interferon signaling pathway (GO:0060337)3.45251106
13cellular response to type I interferon (GO:0071357)3.45251106
14response to type I interferon (GO:0034340)3.40944348
15regulation of interferon-beta biosynthetic process (GO:0045357)3.35197106
16NIK/NF-kappaB signaling (GO:0038061)3.27975881
17neutrophil activation involved in immune response (GO:0002283)3.19381985
18negative regulation of interleukin-12 production (GO:0032695)3.14357360
19positive regulation of interferon-alpha production (GO:0032727)3.12841637
20lipopolysaccharide-mediated signaling pathway (GO:0031663)3.12557787
21regulation of interferon-alpha production (GO:0032647)3.10572758
22antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.07732521
23negative regulation of cell killing (GO:0031342)3.03051834
24negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.03051834
25hepatocyte apoptotic process (GO:0097284)2.99837116
26regulation of type I interferon-mediated signaling pathway (GO:0060338)2.90762074
27nuclear pore complex assembly (GO:0051292)2.90258708
28response to interferon-alpha (GO:0035455)2.88926176
29immunoglobulin mediated immune response (GO:0016064)2.86099966
30macrophage activation involved in immune response (GO:0002281)2.85877019
31germinal center formation (GO:0002467)2.82776913
32mitotic chromosome condensation (GO:0007076)2.76171703
33positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.73397374
34positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.69933322
35regulation of B cell receptor signaling pathway (GO:0050855)2.68415439
36necroptotic process (GO:0070266)2.68113023
37programmed necrotic cell death (GO:0097300)2.65786407
38detection of other organism (GO:0098543)2.63317625
39negative regulation of viral genome replication (GO:0045071)2.61484962
40detection of molecule of bacterial origin (GO:0032490)2.58223830
41positive regulation of interferon-beta production (GO:0032728)2.55609269
42granulocyte activation (GO:0036230)2.55585905
43leukocyte aggregation (GO:0070486)2.53204554
44response to interleukin-15 (GO:0070672)2.50972991
45detection of bacterium (GO:0016045)2.50674737
46DNA unwinding involved in DNA replication (GO:0006268)2.49844515
47positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.49501149
48positive regulation of Cdc42 GTPase activity (GO:0043089)2.49319035
49neutrophil activation (GO:0042119)2.48930173
50B cell mediated immunity (GO:0019724)2.48009462
51positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.47819330
52necrotic cell death (GO:0070265)2.45577773
53T cell migration (GO:0072678)2.45051231
54response to muramyl dipeptide (GO:0032495)2.44610447
55pyrimidine nucleoside salvage (GO:0043097)2.43957345
56pyrimidine-containing compound salvage (GO:0008655)2.43957345
57antigen processing and presentation via MHC class Ib (GO:0002475)2.43926712
58Golgi transport vesicle coating (GO:0048200)2.42575297
59COPI coating of Golgi vesicle (GO:0048205)2.42575297
60pore complex assembly (GO:0046931)2.42484101
61response to interferon-beta (GO:0035456)2.39931228
62cellular response to virus (GO:0098586)2.39427094
63positive regulation of T cell mediated cytotoxicity (GO:0001916)2.36554687
64myeloid dendritic cell differentiation (GO:0043011)2.35586925
65interferon-gamma-mediated signaling pathway (GO:0060333)2.35512626
66detection of external biotic stimulus (GO:0098581)2.35156529
67positive regulation of alpha-beta T cell proliferation (GO:0046641)2.34724832
68myeloid cell activation involved in immune response (GO:0002275)2.34699195
69B cell receptor signaling pathway (GO:0050853)2.34521708
70regulation of alpha-beta T cell proliferation (GO:0046640)2.34238892
71cellular extravasation (GO:0045123)2.32900714
72negative regulation of myeloid cell apoptotic process (GO:0033033)2.32520908
73negative regulation of cytokine production involved in immune response (GO:0002719)2.31830376
74interferon-gamma secretion (GO:0072643)2.31551764
75nuclear pore organization (GO:0006999)2.31497389
76regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.31061151
77regulation of necroptotic process (GO:0060544)2.30920616
78positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.29640325
79regulation of superoxide anion generation (GO:0032928)2.28119086
80cellular response to interferon-alpha (GO:0035457)2.28087232
81regulation of B cell apoptotic process (GO:0002902)2.27687073
82antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.27585469
83response to host (GO:0075136)2.27253698
84response to host defenses (GO:0052200)2.27253698
85response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.27253698
86regulation of gamma-delta T cell activation (GO:0046643)2.27147557
87regulation of T cell tolerance induction (GO:0002664)2.26933729
88gonadal mesoderm development (GO:0007506)2.26035306
89response to host immune response (GO:0052572)2.25783021
90response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.25783021
91positive regulation of macrophage differentiation (GO:0045651)2.25551885
92regulation of viral genome replication (GO:0045069)2.24999422
93positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.24886684
94positive regulation of natural killer cell differentiation (GO:0032825)2.24682140
95regulation of T-helper 1 cell differentiation (GO:0045625)2.24492697
96antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.24285705
97mitotic sister chromatid segregation (GO:0000070)2.24231485
98pinocytosis (GO:0006907)2.23893413
99regulation of mast cell degranulation (GO:0043304)2.23182640
100defense response to protozoan (GO:0042832)2.22879508

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.02752913
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.36874989
3FOXM1_23109430_ChIP-Seq_U2OS_Human2.94297772
4EGR1_19374776_ChIP-ChIP_THP-1_Human2.82599528
5IRF8_21731497_ChIP-ChIP_J774_Mouse2.48234886
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.43264358
7MYC_22102868_ChIP-Seq_BL_Human2.37554636
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.31975189
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.24165617
10SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.19352537
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.14328949
12NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.12799206
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.10767164
14STAT4_19710469_ChIP-ChIP_TH1__Mouse2.06641059
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.05024849
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.03911594
17NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.01456470
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.01293827
19SPI1_23547873_ChIP-Seq_NB4_Human1.96797446
20VDR_21846776_ChIP-Seq_THP-1_Human1.93401616
21E2F4_17652178_ChIP-ChIP_JURKAT_Human1.91944579
22SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.91647792
23ELF1_17652178_ChIP-ChIP_JURKAT_Human1.89857382
24SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.84780008
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.82273771
26* MAF_26560356_Chip-Seq_TH1_Human1.80830751
27TFEB_21752829_ChIP-Seq_HELA_Human1.79407586
28STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.74880680
29CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.73185045
30FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.72498144
31* MYB_26560356_Chip-Seq_TH2_Human1.67488424
32RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.66820365
33IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.66480033
34BRD4_27068464_Chip-Seq_AML-cells_Mouse1.65051805
35IRF8_27001747_Chip-Seq_BMDM_Mouse1.63804028
36ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.63533347
37* MYB_26560356_Chip-Seq_TH1_Human1.59516053
38DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.59408237
39SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.56063738
40MYC_18555785_ChIP-Seq_MESCs_Mouse1.53894204
41DCP1A_22483619_ChIP-Seq_HELA_Human1.53818430
42TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.51561035
43RUNX1_22412390_ChIP-Seq_EML_Mouse1.48984634
44JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.48666550
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.48502605
46ELK3_25401928_ChIP-Seq_HUVEC_Human1.46900662
47STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.46157402
48VDR_24763502_ChIP-Seq_THP-1_Human1.46056657
49NELFA_20434984_ChIP-Seq_ESCs_Mouse1.45274935
50RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.45119754
51MYC_18358816_ChIP-ChIP_MESCs_Mouse1.44274502
52UTX_26944678_Chip-Seq_JUKART_Human1.43782368
53TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42683870
54SPI1_23127762_ChIP-Seq_K562_Human1.39544214
55MYC_19030024_ChIP-ChIP_MESCs_Mouse1.37345062
56CIITA_25753668_ChIP-Seq_RAJI_Human1.37267833
57CREB1_15753290_ChIP-ChIP_HEK293T_Human1.35401790
58KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.34568840
59MAF_26560356_Chip-Seq_TH2_Human1.34371597
60E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.29465032
61ERG_20887958_ChIP-Seq_HPC-7_Mouse1.27806890
62GATA1_22025678_ChIP-Seq_K562_Human1.25283297
63HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.23905279
64NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.20957254
65ETS1_20019798_ChIP-Seq_JURKAT_Human1.20698533
66NCOR1_26117541_ChIP-Seq_K562_Human1.20148082
67E2F1_21310950_ChIP-Seq_MCF-7_Human1.20028227
68KDM5A_27292631_Chip-Seq_BREAST_Human1.18622797
69MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.17478237
70STAT3_1855785_ChIP-Seq_MESCs_Mouse1.17060227
71FOXP3_21729870_ChIP-Seq_TREG_Human1.16777914
72GATA2_22383799_ChIP-Seq_G1ME_Mouse1.15984511
73GABP_19822575_ChIP-Seq_HepG2_Human1.15500981
74CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.13776777
75KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.13433577
76KLF4_18555785_ChIP-Seq_MESCs_Mouse1.12143665
77SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.11733477
78GABP_17652178_ChIP-ChIP_JURKAT_Human1.11601546
79MYCN_18555785_ChIP-Seq_MESCs_Mouse1.10940084
80TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.09979125
81TCF7_22412390_ChIP-Seq_EML_Mouse1.09464849
82GATA1_22383799_ChIP-Seq_G1ME_Mouse1.09081442
83MYC_19079543_ChIP-ChIP_MESCs_Mouse1.08098569
84EST1_17652178_ChIP-ChIP_JURKAT_Human1.08079305
85GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.07724416
86VDR_23849224_ChIP-Seq_CD4+_Human1.07689131
87ATF3_27146783_Chip-Seq_COLON_Human1.07003950
88CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.06896726
89CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.05877892
90E2F1_18555785_ChIP-Seq_MESCs_Mouse1.04734657
91XRN2_22483619_ChIP-Seq_HELA_Human1.03570933
92THAP11_20581084_ChIP-Seq_MESCs_Mouse1.03107883
93ZFX_18555785_ChIP-Seq_MESCs_Mouse1.02829255
94KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.02318012
95TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.01302206
96NOTCH1_21737748_ChIP-Seq_TLL_Human1.00618212
97CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.00419085
98NANOG_18555785_ChIP-Seq_MESCs_Mouse0.99824670
99FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.99243224
100PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98206756

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.08684234
2MP0003436_decreased_susceptibility_to2.93026903
3MP0003303_peritoneal_inflammation2.77344275
4MP0002877_abnormal_melanocyte_morpholog2.56003093
5MP0005451_abnormal_body_composition2.47435057
6MP0000685_abnormal_immune_system2.44211956
7MP0009785_altered_susceptibility_to2.23786491
8MP0003763_abnormal_thymus_physiology2.23596088
9MP0005671_abnormal_response_to2.22046402
10MP0009333_abnormal_splenocyte_physiolog2.19833752
11MP0005000_abnormal_immune_tolerance2.19796440
12MP0003191_abnormal_cellular_cholesterol2.17121046
13MP0002148_abnormal_hypersensitivity_rea2.15175293
14MP0001800_abnormal_humoral_immune2.15155372
15MP0005387_immune_system_phenotype2.11293738
16MP0001790_abnormal_immune_system2.11293738
17MP0003724_increased_susceptibility_to2.08488607
18MP0006082_CNS_inflammation2.06185755
19MP0002419_abnormal_innate_immunity2.03694190
20MP0002723_abnormal_immune_serum2.02832437
21MP0005025_abnormal_response_to2.02461154
22MP0002452_abnormal_antigen_presenting2.01128748
23MP0003300_gastrointestinal_ulcer1.95671051
24MP0005058_abnormal_lysosome_morphology1.90007864
25MP0002420_abnormal_adaptive_immunity1.88495618
26MP0001819_abnormal_immune_cell1.87092555
27MP0003806_abnormal_nucleotide_metabolis1.84470905
28MP0001853_heart_inflammation1.79941351
29MP0002398_abnormal_bone_marrow1.79386679
30MP0003111_abnormal_nucleus_morphology1.77370010
31MP0002254_reproductive_system_inflammat1.75934207
32MP0008057_abnormal_DNA_replication1.72992056
33MP0000858_altered_metastatic_potential1.70558590
34MP0003693_abnormal_embryo_hatching1.67030548
35MP0002405_respiratory_system_inflammati1.66388324
36MP0004947_skin_inflammation1.65748574
37MP0000716_abnormal_immune_system1.60795619
38MP0005464_abnormal_platelet_physiology1.58911321
39MP0010094_abnormal_chromosome_stability1.56437950
40MP0002722_abnormal_immune_system1.54158786
41MP0003172_abnormal_lysosome_physiology1.52903213
42MP0008260_abnormal_autophagy1.51111064
43MP0000689_abnormal_spleen_morphology1.49886635
44MP0002429_abnormal_blood_cell1.47393678
45MP0001845_abnormal_inflammatory_respons1.44188744
46MP0000703_abnormal_thymus_morphology1.44135956
47MP0001533_abnormal_skeleton_physiology1.44124905
48MP0004233_abnormal_muscle_weight1.43846623
49MP0002396_abnormal_hematopoietic_system1.43772959
50MP0005076_abnormal_cell_differentiation1.41446002
51MP0003566_abnormal_cell_adhesion1.40682697
52MP0004957_abnormal_blastocyst_morpholog1.38489474
53MP0004808_abnormal_hematopoietic_stem1.38184127
54MP0003950_abnormal_plasma_membrane1.37676916
55MP0002166_altered_tumor_susceptibility1.35583905
56MP0001873_stomach_inflammation1.34047236
57MP0009840_abnormal_foam_cell1.33678229
58MP0003077_abnormal_cell_cycle1.33163127
59MP0008469_abnormal_protein_level1.26575300
60MP0003656_abnormal_erythrocyte_physiolo1.22185223
61MP0002006_tumorigenesis1.21969293
62MP0010155_abnormal_intestine_physiology1.21377328
63MP0008007_abnormal_cellular_replicative1.16040056
64MP0010307_abnormal_tumor_latency1.14219957
65MP0009764_decreased_sensitivity_to1.14076519
66MP0002019_abnormal_tumor_incidence1.13401880
67MP0003091_abnormal_cell_migration1.12898897
68MP0003221_abnormal_cardiomyocyte_apopto1.09714301
69MP0010352_gastrointestinal_tract_polyps1.09600894
70MP0009278_abnormal_bone_marrow1.06008977
71MP0001348_abnormal_lacrimal_gland1.02487842
72MP0003448_altered_tumor_morphology1.01478323
73MP0003786_premature_aging1.01313204
74MP0008058_abnormal_DNA_repair1.01030451
75MP0000490_abnormal_crypts_of1.00795729
76MP0000343_altered_response_to0.99775515
77MP0005310_abnormal_salivary_gland0.98952568
78MP0003075_altered_response_to0.94922395
79MP0003828_pulmonary_edema0.93587054
80MP0005621_abnormal_cell_physiology0.92806620
81MP0000313_abnormal_cell_death0.92609820
82MP0004510_myositis0.91210324
83MP0005083_abnormal_biliary_tract0.89371312
84MP0000350_abnormal_cell_proliferation0.89214698
85MP0000015_abnormal_ear_pigmentation0.89208103
86MP0003453_abnormal_keratinocyte_physiol0.85751614
87MP0005397_hematopoietic_system_phenotyp0.84415096
88MP0001545_abnormal_hematopoietic_system0.84415096
89MP0004185_abnormal_adipocyte_glucose0.83842476
90MP0002132_abnormal_respiratory_system0.83832779
91MP0000358_abnormal_cell_content/0.83457839
92MP0005164_abnormal_response_to0.80937937
93MP0001730_embryonic_growth_arrest0.78547072
94MP0005384_cellular_phenotype0.76192197
95MP0003705_abnormal_hypodermis_morpholog0.75378670
96MP0006054_spinal_hemorrhage0.75328384
97MP0000609_abnormal_liver_physiology0.74388193
98MP0009763_increased_sensitivity_to0.73424560
99MP0006035_abnormal_mitochondrial_morpho0.72371910
100MP0003045_fibrosis0.71602687

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of macrophages (HP:0004311)4.09587306
2Recurrent abscess formation (HP:0002722)3.97915251
3Recurrent bacterial skin infections (HP:0005406)3.82052433
4Abnormality of liposaccharide metabolism (HP:0010968)3.51414464
5Abnormality of glycosphingolipid metabolism (HP:0004343)3.51414464
6Abnormality of glycolipid metabolism (HP:0010969)3.51414464
7Myositis (HP:0100614)3.49143062
8Orchitis (HP:0100796)3.46711196
9Elevated erythrocyte sedimentation rate (HP:0003565)3.39026360
10Eczematoid dermatitis (HP:0000976)3.28647183
11Optic neuritis (HP:0100653)3.23009037
12Retrobulbar optic neuritis (HP:0100654)3.23009037
13Recurrent viral infections (HP:0004429)3.19593001
14Abnormal delayed hypersensitivity skin test (HP:0002963)3.18900111
15Recurrent fungal infections (HP:0002841)3.02993024
16Mediastinal lymphadenopathy (HP:0100721)2.97353131
17Chronic mucocutaneous candidiasis (HP:0002728)2.88544073
18Recurrent cutaneous fungal infections (HP:0011370)2.88544073
19Obstructive lung disease (HP:0006536)2.85234839
20Chronic obstructive pulmonary disease (HP:0006510)2.85234839
21Gastrointestinal infarctions (HP:0005244)2.79985207
22Fatigue (HP:0012378)2.74388120
23Vacuolated lymphocytes (HP:0001922)2.72115868
24Increased IgM level (HP:0003496)2.68553018
25Meningitis (HP:0001287)2.67986465
26Recurrent skin infections (HP:0001581)2.67509553
27Hypertensive crisis (HP:0100735)2.60183135
28Abnormality of T cell physiology (HP:0011840)2.58496058
29Encephalitis (HP:0002383)2.56219899
30Autoimmune hemolytic anemia (HP:0001890)2.54990600
31Stomatitis (HP:0010280)2.53712677
32T lymphocytopenia (HP:0005403)2.52981847
33Vasculitis (HP:0002633)2.48844688
34Abnormality of T cell number (HP:0011839)2.47553557
35Abnormality of T cells (HP:0002843)2.44552915
36Autoimmune thrombocytopenia (HP:0001973)2.38547191
37Dysostosis multiplex (HP:0000943)2.32795404
38Petechiae (HP:0000967)2.29319759
39Pustule (HP:0200039)2.26427908
40Cellulitis (HP:0100658)2.26109112
41Urticaria (HP:0001025)2.25981740
42Entropion (HP:0000621)2.25597364
43Pulmonary infiltrates (HP:0002113)2.24905667
44Vertebral compression fractures (HP:0002953)2.23834106
45Colitis (HP:0002583)2.22145218
46Myocardial infarction (HP:0001658)2.21833394
47Viral hepatitis (HP:0006562)2.21532730
48Increased cerebral lipofuscin (HP:0011813)2.17507161
49Anorexia (HP:0002039)2.16622658
50Keratoconjunctivitis sicca (HP:0001097)2.14694413
51Interstitial pulmonary disease (HP:0006530)2.14588054
52Arterial thrombosis (HP:0004420)2.14029105
53Increased serum ferritin (HP:0003281)2.11186079
54Rough bone trabeculation (HP:0100670)2.09246446
55Granulocytopenia (HP:0001913)2.07964069
56Orthostatic hypotension (HP:0001278)2.06620945
57Abnormal gallbladder physiology (HP:0012438)2.05972884
58Cholecystitis (HP:0001082)2.05972884
59Poikiloderma (HP:0001029)2.03447446
60Abnormality of cells of the lymphoid lineage (HP:0012140)2.03395011
61Gastrointestinal inflammation (HP:0004386)2.02806307
62Micronodular cirrhosis (HP:0001413)2.02083658
63Panhypogammaglobulinemia (HP:0003139)2.01539116
64Slow saccadic eye movements (HP:0000514)2.01284266
65Keratoconjunctivitis (HP:0001096)1.99678879
66Glomerulopathy (HP:0100820)1.99344052
67Inflammation of the large intestine (HP:0002037)1.98395086
68Acute hepatic failure (HP:0006554)1.98370509
69Thrombocytosis (HP:0001894)1.97427896
70IgA deficiency (HP:0002720)1.96738293
71Abnormality of mucopolysaccharide metabolism (HP:0011020)1.96589826
72Abnormality of polysaccharide metabolism (HP:0011012)1.96589826
73Abnormality of glycosaminoglycan metabolism (HP:0004371)1.96589826
74Increased neuronal autofluorescent lipopigment (HP:0002074)1.96365631
75Lymphopenia (HP:0001888)1.95561883
76Subacute progressive viral hepatitis (HP:0006572)1.95076040
77Squamous cell carcinoma (HP:0002860)1.93950688
78Reduced subcutaneous adipose tissue (HP:0003758)1.93635585
79Nonimmune hydrops fetalis (HP:0001790)1.93529388
80Hypergammaglobulinemia (HP:0010702)1.92712519
81Progressive neurologic deterioration (HP:0002344)1.90834228
82Chest pain (HP:0100749)1.90804131
83Abnormality of the pericardium (HP:0001697)1.88984800
84Urinary glycosaminoglycan excretion (HP:0003541)1.87513432
85Mucopolysacchariduria (HP:0008155)1.87513432
86Hepatosplenomegaly (HP:0001433)1.86832164
87Cutaneous melanoma (HP:0012056)1.85120616
88Lymphoma (HP:0002665)1.84944306
89Hypokinesia (HP:0002375)1.84344206
90Abnormality of oral frenula (HP:0000190)1.82690993
91Abnormality of the peritoneum (HP:0002585)1.80966334
92Chromosomal breakage induced by crosslinking agents (HP:0003221)1.80282364
93Recurrent gram-negative bacterial infections (HP:0005420)1.78209734
94Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.77751944
95Gastrointestinal stroma tumor (HP:0100723)1.77272233
96Osteomyelitis (HP:0002754)1.75694737
97Amaurosis fugax (HP:0100576)1.74912979
98Aplasia/Hypoplasia of the thymus (HP:0010515)1.74394746
99Epistaxis (HP:0000421)1.73506661
100Abnormal trabecular bone morphology (HP:0100671)1.71888022

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK33.42123760
2PRPF4B2.79367554
3TESK22.77607753
4RIPK42.36768620
5ERN12.35388126
6IRAK42.32345369
7MAP4K12.31800312
8NME22.30345434
9MAP3K142.30054746
10TYK22.27985655
11SMG12.27884743
12BUB12.14645065
13MAP2K32.09389718
14STK101.95239409
15TAOK21.84873351
16MAP3K31.78826315
17SIK31.71790528
18TBK11.69015267
19JAK31.67750547
20TRIB31.61067038
21BLK1.56695573
22ICK1.46653933
23ZAP701.43041271
24IKBKE1.41008230
25KSR21.39514546
26MAP3K81.38366931
27PAK41.36513047
28CDK121.35416582
29CLK11.27190970
30EIF2AK11.25625872
31CSK1.22844569
32BMPR21.16624971
33MAP3K131.09538179
34PBK1.08349554
35MARK31.07907079
36IKBKB1.06688758
37VRK21.03359944
38EPHB11.02610118
39EPHA21.00218039
40JAK10.98603508
41MELK0.97055598
42MST1R0.96757127
43CDK80.90685164
44BTK0.89935020
45MAP3K10.86258977
46WEE10.85283714
47GRK60.84977986
48STK40.83921636
49MAP3K110.83501581
50SCYL20.82219733
51CCNB10.81193224
52HCK0.80526103
53FGR0.79816877
54MAP3K20.78216170
55TESK10.78206779
56MST40.77728079
57IRAK10.77264302
58RAF10.76561844
59IRAK20.76168409
60SYK0.74848797
61TXK0.73447571
62JAK20.73115292
63MAPK110.72349720
64TTK0.71857732
65CHEK20.71402245
66EEF2K0.70073008
67TGFBR20.67896291
68CDK70.67537071
69GRK70.67274931
70MOS0.67136243
71MAP3K50.67001276
72LRRK20.66422842
73CSF1R0.65130895
74RPS6KB20.64805281
75CDK40.64401496
76YES10.62823006
77MAP3K100.62228513
78KSR10.61766470
79BRAF0.60713420
80SRPK10.60683463
81SIK10.60069469
82FGFR40.60043754
83PIM10.59177093
84BRSK10.59112664
85ARAF0.58199668
86CDC70.57206100
87LCK0.56867145
88LYN0.54759055
89EIF2AK30.52941510
90TAF10.51409292
91BMX0.50489840
92PDK10.50416352
93NEK90.49962974
94PDPK10.49913325
95TAOK10.49864021
96MAPKAPK20.49337763
97PAK10.46459766
98MAP3K120.44517873
99EIF2AK20.44397328
100CDK90.43737082

Predicted pathways (KEGG)

RankGene SetZ-score
1Toll-like receptor signaling pathway_Homo sapiens_hsa046202.05525714
2Other glycan degradation_Homo sapiens_hsa005112.05018865
3DNA replication_Homo sapiens_hsa030302.04936667
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.04252094
5RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.02498776
6Measles_Homo sapiens_hsa051622.02253646
7Osteoclast differentiation_Homo sapiens_hsa043801.97972561
8Leishmaniasis_Homo sapiens_hsa051401.94113108
9Primary immunodeficiency_Homo sapiens_hsa053401.89818143
10Allograft rejection_Homo sapiens_hsa053301.84194160
11Proteasome_Homo sapiens_hsa030501.82978082
12B cell receptor signaling pathway_Homo sapiens_hsa046621.77789349
13Graft-versus-host disease_Homo sapiens_hsa053321.77498939
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.74857815
15Influenza A_Homo sapiens_hsa051641.69352010
16Herpes simplex infection_Homo sapiens_hsa051681.66577057
17Antigen processing and presentation_Homo sapiens_hsa046121.63647228
18Shigellosis_Homo sapiens_hsa051311.62545275
19Legionellosis_Homo sapiens_hsa051341.60902246
20Autoimmune thyroid disease_Homo sapiens_hsa053201.54975183
21Hepatitis B_Homo sapiens_hsa051611.54427034
22NOD-like receptor signaling pathway_Homo sapiens_hsa046211.52827767
23Acute myeloid leukemia_Homo sapiens_hsa052211.51529353
24Tuberculosis_Homo sapiens_hsa051521.47138523
25* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.46322214
26TNF signaling pathway_Homo sapiens_hsa046681.44611472
27Apoptosis_Homo sapiens_hsa042101.41929868
28Chronic myeloid leukemia_Homo sapiens_hsa052201.41435958
29Viral myocarditis_Homo sapiens_hsa054161.41377040
30Epstein-Barr virus infection_Homo sapiens_hsa051691.37641844
31Viral carcinogenesis_Homo sapiens_hsa052031.36220103
32Toxoplasmosis_Homo sapiens_hsa051451.36030172
33Intestinal immune network for IgA production_Homo sapiens_hsa046721.35909833
34T cell receptor signaling pathway_Homo sapiens_hsa046601.33105038
35Pancreatic cancer_Homo sapiens_hsa052121.33021339
36Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.29459024
37Non-small cell lung cancer_Homo sapiens_hsa052231.26296618
38Hepatitis C_Homo sapiens_hsa051601.26133085
39Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.25210968
40Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.23519276
41Mismatch repair_Homo sapiens_hsa034301.22196471
42Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.17304693
43Hematopoietic cell lineage_Homo sapiens_hsa046401.16526259
44Bladder cancer_Homo sapiens_hsa052191.15750999
45Malaria_Homo sapiens_hsa051441.15370213
46Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.11532778
47Glycosaminoglycan degradation_Homo sapiens_hsa005311.09263637
48Cell cycle_Homo sapiens_hsa041101.07969236
49Jak-STAT signaling pathway_Homo sapiens_hsa046301.06655397
50Staphylococcus aureus infection_Homo sapiens_hsa051501.05906558
51Lysosome_Homo sapiens_hsa041421.04986928
52Nucleotide excision repair_Homo sapiens_hsa034201.03081273
53Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.01494003
54Homologous recombination_Homo sapiens_hsa034401.01203558
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.00300806
56Salmonella infection_Homo sapiens_hsa051321.00074749
57Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.99126557
58One carbon pool by folate_Homo sapiens_hsa006700.98710029
59Pyrimidine metabolism_Homo sapiens_hsa002400.98220898
60HTLV-I infection_Homo sapiens_hsa051660.97444707
61Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.95841131
62African trypanosomiasis_Homo sapiens_hsa051430.94766541
63Base excision repair_Homo sapiens_hsa034100.94390786
64Type I diabetes mellitus_Homo sapiens_hsa049400.92241110
65Asthma_Homo sapiens_hsa053100.91998766
66Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.91164011
67N-Glycan biosynthesis_Homo sapiens_hsa005100.88836040
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.88540214
69Rheumatoid arthritis_Homo sapiens_hsa053230.88389837
70p53 signaling pathway_Homo sapiens_hsa041150.86912202
71Phagosome_Homo sapiens_hsa041450.86898347
72Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.81911579
73Chemokine signaling pathway_Homo sapiens_hsa040620.78489370
74Thyroid cancer_Homo sapiens_hsa052160.78480835
75Non-homologous end-joining_Homo sapiens_hsa034500.77463598
76Pertussis_Homo sapiens_hsa051330.77339097
77Renal cell carcinoma_Homo sapiens_hsa052110.77048124
78Pentose phosphate pathway_Homo sapiens_hsa000300.76562621
79Small cell lung cancer_Homo sapiens_hsa052220.76077711
80Spliceosome_Homo sapiens_hsa030400.68677762
81VEGF signaling pathway_Homo sapiens_hsa043700.66718821
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.65389734
83Systemic lupus erythematosus_Homo sapiens_hsa053220.64192332
84Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.64031562
85Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62659983
86RNA transport_Homo sapiens_hsa030130.61509105
87Prolactin signaling pathway_Homo sapiens_hsa049170.59348849
88Leukocyte transendothelial migration_Homo sapiens_hsa046700.59126779
89Prostate cancer_Homo sapiens_hsa052150.58840715
90Neurotrophin signaling pathway_Homo sapiens_hsa047220.58481841
91AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57704426
92Central carbon metabolism in cancer_Homo sapiens_hsa052300.57316893
93Galactose metabolism_Homo sapiens_hsa000520.55510660
94Endometrial cancer_Homo sapiens_hsa052130.54520351
95Endocytosis_Homo sapiens_hsa041440.53913174
96Fanconi anemia pathway_Homo sapiens_hsa034600.52571799
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.51302569
98Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50058634
99HIF-1 signaling pathway_Homo sapiens_hsa040660.48112495
100Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43892646

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