MIB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an E3 ubiquitin protein ligase that mediates ubiquitination of proteins in the Notch signaling pathway. The encoded protein may be a suppressor of melanoma invasion. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.02503119
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.64071284
3locomotory exploration behavior (GO:0035641)5.41309159
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.09349958
5sodium ion export (GO:0071436)4.64014263
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.58797871
7synaptic vesicle docking involved in exocytosis (GO:0016081)4.54543393
8glutamate secretion (GO:0014047)4.47958634
9regulation of synapse structural plasticity (GO:0051823)4.37372554
10negative regulation of erythrocyte differentiation (GO:0045647)4.33478041
11layer formation in cerebral cortex (GO:0021819)4.16810724
12synaptic vesicle exocytosis (GO:0016079)4.13416999
13regulation of synaptic vesicle exocytosis (GO:2000300)4.07581584
14regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.05068685
15vocalization behavior (GO:0071625)4.00933913
16mannose metabolic process (GO:0006013)3.98085058
17activation of protein kinase A activity (GO:0034199)3.97405054
18regulation of glutamate receptor signaling pathway (GO:1900449)3.96649239
19cellular potassium ion homeostasis (GO:0030007)3.96521288
20regulation of neuronal synaptic plasticity (GO:0048168)3.91610461
21proline transport (GO:0015824)3.86380448
22neurotransmitter secretion (GO:0007269)3.85961083
23cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.81759582
24negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.79448210
25regulation of long-term neuronal synaptic plasticity (GO:0048169)3.76028374
26neuromuscular process controlling balance (GO:0050885)3.74390354
27negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.72501645
28negative regulation of cell killing (GO:0031342)3.72501645
29exploration behavior (GO:0035640)3.70715089
30cell communication by electrical coupling (GO:0010644)3.64581973
31regulation of ARF protein signal transduction (GO:0032012)3.62665270
32regulation of synaptic vesicle transport (GO:1902803)3.61545997
33positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.59891793
34gamma-aminobutyric acid transport (GO:0015812)3.59119089
35dendritic spine morphogenesis (GO:0060997)3.57686541
36antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.57409162
37cytoskeletal anchoring at plasma membrane (GO:0007016)3.52352873
38positive regulation of synapse maturation (GO:0090129)3.34226070
39neuromuscular process controlling posture (GO:0050884)3.32503517
40ionotropic glutamate receptor signaling pathway (GO:0035235)3.31338382
41G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.31159758
42alanine transport (GO:0032328)3.29130504
43regulation of ARF GTPase activity (GO:0032312)3.23950508
44glycine transport (GO:0015816)3.22495761
45cerebellar Purkinje cell layer development (GO:0021680)3.21773209
46antigen processing and presentation of endogenous antigen (GO:0019883)3.20524709
47potassium ion import (GO:0010107)3.18652596
48antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.15773493
49long-term memory (GO:0007616)3.14239160
50membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.11100512
51neuronal action potential propagation (GO:0019227)3.10737434
52positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.09603272
53vesicle transport along microtubule (GO:0047496)3.08245654
54neurotransmitter-gated ion channel clustering (GO:0072578)3.06982543
55antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.06459328
56cellular sodium ion homeostasis (GO:0006883)3.05831138
57positive thymic T cell selection (GO:0045059)3.02497058
58protein localization to synapse (GO:0035418)3.00980597
59negative regulation of myotube differentiation (GO:0010832)3.00213861
60adherens junction assembly (GO:0034333)2.95573446
61synaptic transmission, glutamatergic (GO:0035249)2.95531080
62focal adhesion assembly (GO:0048041)2.94555032
63cell-substrate adherens junction assembly (GO:0007045)2.94555032
64thymic T cell selection (GO:0045061)2.94509477
65prepulse inhibition (GO:0060134)2.93045886
66synaptic vesicle endocytosis (GO:0048488)2.91395604
67cerebellar Purkinje cell differentiation (GO:0021702)2.90926726
68establishment of nucleus localization (GO:0040023)2.90909809
69positive regulation of membrane potential (GO:0045838)2.89907862
70regulation of synaptic plasticity (GO:0048167)2.89133150
71positive regulation of histone deacetylation (GO:0031065)2.89104702
72neurotransmitter transport (GO:0006836)2.83902784
73regulation of dendritic spine morphogenesis (GO:0061001)2.83641482
74dendrite morphogenesis (GO:0048813)2.83244294
75apoptotic process involved in morphogenesis (GO:0060561)2.80609809
76regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.77378749
77positive regulation of receptor recycling (GO:0001921)2.76719218
78membrane depolarization during action potential (GO:0086010)2.76092249
79regulation of extracellular matrix disassembly (GO:0010715)2.75980497
80regulation of neurotransmitter levels (GO:0001505)2.75959583
81regulation of excitatory postsynaptic membrane potential (GO:0060079)2.75905309
82cell migration in hindbrain (GO:0021535)2.75765770
83semaphorin-plexin signaling pathway (GO:0071526)2.74360801
84creatine metabolic process (GO:0006600)2.73963140
85activation of JUN kinase activity (GO:0007257)2.72000075
86regulation of clathrin-mediated endocytosis (GO:2000369)2.71710073
87response to auditory stimulus (GO:0010996)2.71151597
88positive regulation of myotube differentiation (GO:0010831)2.68759340
89positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.67587361
90histone H4 deacetylation (GO:0070933)2.67271741
91dendritic spine organization (GO:0097061)2.67133425
92glutamate receptor signaling pathway (GO:0007215)2.65840834
93barbed-end actin filament capping (GO:0051016)2.65647512
94clathrin coat assembly (GO:0048268)2.63425891
95organelle transport along microtubule (GO:0072384)2.63023647
96dopamine receptor signaling pathway (GO:0007212)2.62162281
97cell communication involved in cardiac conduction (GO:0086065)2.61947238
98auditory behavior (GO:0031223)2.61853545
99neuronal ion channel clustering (GO:0045161)2.61594985
100neuromuscular process (GO:0050905)2.61579412
101signal complex assembly (GO:0007172)2.61407112
102stress fiber assembly (GO:0043149)2.60196854
103peptidyl-lysine dimethylation (GO:0018027)2.59561846
104response to laminar fluid shear stress (GO:0034616)2.58408858
105regulation of postsynaptic membrane potential (GO:0060078)2.57718165
106positive regulation of Rap GTPase activity (GO:0032854)2.57635216
107atrioventricular valve morphogenesis (GO:0003181)2.57113869
108potassium ion homeostasis (GO:0055075)2.56572244
109regulation of Rap GTPase activity (GO:0032317)2.54131089
110leukocyte aggregation (GO:0070486)2.53923255
111neuron-neuron synaptic transmission (GO:0007270)2.53920137
112regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.53372593
113germinal center formation (GO:0002467)2.52885257
114activation of MAPKKK activity (GO:0000185)2.51504306
115actin-myosin filament sliding (GO:0033275)2.50720943
116muscle filament sliding (GO:0030049)2.50720943
117membrane repolarization (GO:0086009)2.47421380
118positive regulation of synaptic transmission, GABAergic (GO:0032230)2.46658475
119regulation of neurotransmitter secretion (GO:0046928)2.45379633
120planar cell polarity pathway involved in neural tube closure (GO:0090179)2.45049670
121macroautophagy (GO:0016236)2.43876442
122cell-substrate junction assembly (GO:0007044)2.42839005
123positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.42199917
124response to muramyl dipeptide (GO:0032495)2.41772653
125positive regulation of dendritic spine development (GO:0060999)2.41022005
126detection of bacterium (GO:0016045)2.40911021
127axon cargo transport (GO:0008088)2.40787367
128mating behavior (GO:0007617)2.40171133
129cell-cell junction maintenance (GO:0045217)2.39350692
130positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.39324250
131regulation of female receptivity (GO:0045924)2.38849345
132membrane depolarization (GO:0051899)2.38477536
133histone H3 deacetylation (GO:0070932)2.38380629
134regulation of necroptotic process (GO:0060544)2.38111705
135positive regulation of fibroblast migration (GO:0010763)2.37258740
136positive regulation of gamma-delta T cell activation (GO:0046645)2.37190228
137positive regulation of protein dephosphorylation (GO:0035307)2.36607426
138long-term synaptic potentiation (GO:0060291)2.36601091
139negative regulation of cell size (GO:0045792)2.36258692
140negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.36131782
141cAMP biosynthetic process (GO:0006171)2.35600794
142regulation of calcium ion-dependent exocytosis (GO:0017158)2.35329127
143negative regulation of necroptotic process (GO:0060546)2.34540918
144peptidyl-tyrosine autophosphorylation (GO:0038083)2.33472738
145myofibril assembly (GO:0030239)2.33088084
146positive regulation of protein deacetylation (GO:0090312)2.32283007
147positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.30073403
148positive regulation of Cdc42 GTPase activity (GO:0043089)2.29822722
149regulation of T-helper 2 cell differentiation (GO:0045628)2.29597142
150detection of other organism (GO:0098543)2.29464862
151regulation of gamma-delta T cell differentiation (GO:0045586)2.29228571
152cardiac muscle contraction (GO:0060048)2.28540844
153activation of Rac GTPase activity (GO:0032863)2.28410047
154insulin-like growth factor receptor signaling pathway (GO:0048009)2.26977124
155protein localization to endosome (GO:0036010)2.26407969
156macrophage activation involved in immune response (GO:0002281)2.26259221
157skeletal muscle contraction (GO:0003009)2.25671152
158cardiac myofibril assembly (GO:0055003)2.25377677
159endothelial cell chemotaxis (GO:0035767)2.25052006
160T cell selection (GO:0045058)2.25001693
161protein targeting to plasma membrane (GO:0072661)2.24605476
162regulation of gamma-delta T cell activation (GO:0046643)2.24099572
163regulation of glucose import in response to insulin stimulus (GO:2001273)2.23495240
164cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.23147643
165regulation of early endosome to late endosome transport (GO:2000641)2.22188824
166regulation of NFAT protein import into nucleus (GO:0051532)2.21882109
167sarcoplasmic reticulum calcium ion transport (GO:0070296)2.21176706
168positive regulation of blood vessel endothelial cell migration (GO:0043536)2.20360923
169regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.16749547
170regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.11130296
171cell volume homeostasis (GO:0006884)2.11104622
172skeletal muscle adaptation (GO:0043501)2.10995977
173venous blood vessel morphogenesis (GO:0048845)2.10935178
174response to fluid shear stress (GO:0034405)2.10278003
175vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.08282553
176epithelial cell differentiation involved in prostate gland development (GO:0060742)2.07742114
177regulation of leukocyte degranulation (GO:0043300)2.07213894
178positive regulation of protein kinase C signaling (GO:0090037)2.06785701
179negative regulation of fatty acid transport (GO:2000192)2.06779765
180striated muscle contraction (GO:0006941)2.06061120
181regulation of type I interferon-mediated signaling pathway (GO:0060338)2.05322797
182positive T cell selection (GO:0043368)2.04548955
183modulation by symbiont of host cellular process (GO:0044068)2.04401533
184basement membrane organization (GO:0071711)2.03650570
185negative thymic T cell selection (GO:0045060)2.03321819
186intracellular estrogen receptor signaling pathway (GO:0030520)2.02761724
187negative regulation of necrotic cell death (GO:0060547)2.02713661

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.48138905
2EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.32303784
3MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.91583781
4RARB_27405468_Chip-Seq_BRAIN_Mouse2.90488665
5DROSHA_22980978_ChIP-Seq_HELA_Human2.87757649
6RARG_19884340_ChIP-ChIP_MEFs_Mouse2.75455601
7* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.29226381
8THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.21289257
9* LXR_22292898_ChIP-Seq_THP-1_Human2.20203459
10* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.19911199
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.18548825
12* KDM2B_26808549_Chip-Seq_K562_Human2.16375087
13TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.12287815
14REST_21632747_ChIP-Seq_MESCs_Mouse2.09558070
15ERG_21242973_ChIP-ChIP_JURKAT_Human2.09412017
16* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.98781189
17* KDM2B_26808549_Chip-Seq_DND41_Human1.96938979
18IKZF1_21737484_ChIP-ChIP_HCT116_Human1.96788600
19SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.91546119
20DNAJC2_21179169_ChIP-ChIP_NT2_Human1.90600081
21MTF2_20144788_ChIP-Seq_MESCs_Mouse1.90218568
22REST_18959480_ChIP-ChIP_MESCs_Mouse1.90142351
23SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.88460826
24SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.88112291
25TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.86677625
26EZH2_18974828_ChIP-Seq_MESCs_Mouse1.86625226
27RNF2_18974828_ChIP-Seq_MESCs_Mouse1.86625226
28SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.81134581
29ZFP281_27345836_Chip-Seq_ESCs_Mouse1.81060987
30WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.79341455
31NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.76618634
32GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.73719931
33JARID2_20075857_ChIP-Seq_MESCs_Mouse1.72102188
34TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.72006428
35ZNF263_19887448_ChIP-Seq_K562_Human1.67667963
36JARID2_20064375_ChIP-Seq_MESCs_Mouse1.66637873
37SUZ12_27294783_Chip-Seq_ESCs_Mouse1.65101154
38PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.65045972
39EZH2_27294783_Chip-Seq_ESCs_Mouse1.64995032
40NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.63469361
41ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.60329535
42* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.60085632
43CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.59586385
44VDR_24763502_ChIP-Seq_THP-1_Human1.59337835
45* KDM2B_26808549_Chip-Seq_JURKAT_Human1.56474058
46BP1_19119308_ChIP-ChIP_Hs578T_Human1.56125437
47TCF7_22412390_ChIP-Seq_EML_Mouse1.54187081
48DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.53691055
49RNF2_27304074_Chip-Seq_ESCs_Mouse1.51651070
50* MAF_26560356_Chip-Seq_TH1_Human1.49977048
51ESR2_21235772_ChIP-Seq_MCF-7_Human1.48992569
52* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.47730519
53SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.45115964
54SMC4_20622854_ChIP-Seq_HELA_Human1.43826681
55SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.43431660
56* MAF_26560356_Chip-Seq_TH2_Human1.41224772
57CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.40450173
58* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.40315474
59UTX_26944678_Chip-Seq_JUKART_Human1.39771023
60* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.39654958
61SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.38139242
62NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.36551322
63SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.36246367
64RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.35942850
65RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.35872429
66SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.35851556
67ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.35404090
68TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.34642682
69RUNX1_22412390_ChIP-Seq_EML_Mouse1.33803002
70TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.33581373
71* BCOR_27268052_Chip-Seq_Bcells_Human1.31370397
72* CREB1_26743006_Chip-Seq_LNCaP_Human1.31150188
73* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.30610738
74* BCL6_27268052_Chip-Seq_Bcells_Human1.29873820
75CTCF_27219007_Chip-Seq_Bcells_Human1.28767118
76SRY_22984422_ChIP-ChIP_TESTIS_Rat1.28194876
77MYC_22102868_ChIP-Seq_BL_Human1.25221886
78TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.23931428
79* TET1_21490601_ChIP-Seq_MESCs_Mouse1.22431389
80EZH2_27304074_Chip-Seq_ESCs_Mouse1.21021611
81* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.20213501
82* RACK7_27058665_Chip-Seq_MCF-7_Human1.19672412
83VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.18993400
84* P68_20966046_ChIP-Seq_HELA_Human1.18973434
85RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.18215643
86* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.17748317
87TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.15457495
88MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.13298924
89BRD4_27068464_Chip-Seq_AML-cells_Mouse1.13030705
90RING1B_27294783_Chip-Seq_ESCs_Mouse1.12665404
91* SA1_27219007_Chip-Seq_Bcells_Human1.12062644
92* ELK3_25401928_ChIP-Seq_HUVEC_Human1.11327936
93GATA1_19941826_ChIP-Seq_K562_Human1.10782814
94* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.08788448
95TBX20_22080862_ChIP-Seq_HEART_Mouse1.07655722
96TBX20_22328084_ChIP-Seq_HEART_Mouse1.07655722
97E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.07461824
98* KLF4_19829295_ChIP-Seq_ESCs_Human1.07154000
99TP53_22127205_ChIP-Seq_IMR90_Human1.06878580
100PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06687304
101SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06470190
102PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.06464133
103NCOR1_26117541_ChIP-Seq_K562_Human1.05803805
104PPARA_22158963_ChIP-Seq_LIVER_Mouse1.05698491
105* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.05552797
106NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.05278566
107* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.05083598
108* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.04991708
109CTCF_21964334_ChIP-Seq_BJAB-B_Human1.02693265
110AR_19668381_ChIP-Seq_PC3_Human1.01948802
111PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.01268065
112MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.00347677
113P63_26484246_Chip-Seq_KERATINOCYTES_Human1.00254530
114SMC1_22415368_ChIP-Seq_MEFs_Mouse0.99633064
115SMC3_22415368_ChIP-Seq_MEFs_Mouse0.99472837
116STAT6_21828071_ChIP-Seq_BEAS2B_Human0.99001614
117* SA1_27219007_Chip-Seq_ERYTHROID_Human0.98756469
118SPI1_23127762_ChIP-Seq_K562_Human0.98635677
119CLOCK_20551151_ChIP-Seq_293T_Human0.98195725
120GATA1_19941827_ChIP-Seq_MEL_Mouse0.98109389
121NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98023008
122GATA1_22383799_ChIP-Seq_G1ME_Mouse0.97506003
123RUNX1_27514584_Chip-Seq_MCF-7_Human0.97146606
124CTCF_26484167_Chip-Seq_Bcells_Mouse0.97132608
125SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.97015509
126JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.96947930
127* OCT4_19829295_ChIP-Seq_ESCs_Human0.96342415
128TP63_22573176_ChIP-Seq_HFKS_Human0.95046837
129OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.93907386
130* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.93057145
131EED_16625203_ChIP-ChIP_MESCs_Mouse0.91336586
132RING1B_27294783_Chip-Seq_NPCs_Mouse0.90879066
133VDR_21846776_ChIP-Seq_THP-1_Human0.90168882
134ELF1_20517297_ChIP-Seq_JURKAT_Human0.89360527
135SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.88671876
136FOXA2_19822575_ChIP-Seq_HepG2_Human0.87898029
137TET1_21451524_ChIP-Seq_MESCs_Mouse0.87673298
138MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.86666706
139EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.85941388
140ESR1_15608294_ChIP-ChIP_MCF-7_Human0.85751125
141ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.85443574
142* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.85233640
143SMAD4_21741376_ChIP-Seq_ESCs_Human0.83621253
144CTNNB1_20460455_ChIP-Seq_HCT116_Human0.83310336
145SOX2_21211035_ChIP-Seq_LN229_Gbm0.83296307

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.03195923
2MP0003635_abnormal_synaptic_transmissio3.76925964
3MP0002822_catalepsy2.88324573
4MP0004270_analgesia2.84127996
5MP0002909_abnormal_adrenal_gland2.83339999
6MP0005451_abnormal_body_composition2.82592858
7MP0002063_abnormal_learning/memory/cond2.80189836
8MP0009745_abnormal_behavioral_response2.69937108
9MP0002064_seizures2.69464475
10MP0009780_abnormal_chondrocyte_physiolo2.57567341
11MP0004858_abnormal_nervous_system2.52751698
12MP0008961_abnormal_basal_metabolism2.51924109
13MP0003436_decreased_susceptibility_to2.48516203
14MP0009046_muscle_twitch2.48331488
15MP0003329_amyloid_beta_deposits2.43214116
16MP0003172_abnormal_lysosome_physiology2.28501623
17MP0003283_abnormal_digestive_organ2.28177632
18MP0008260_abnormal_autophagy2.23972446
19MP0003880_abnormal_central_pattern2.15940832
20MP0002572_abnormal_emotion/affect_behav2.13654401
21MP0001958_emphysema2.07494176
22MP0003279_aneurysm2.03913396
23MP0010234_abnormal_vibrissa_follicle2.03759768
24MP0008438_abnormal_cutaneous_collagen1.96000064
25MP0000569_abnormal_digit_pigmentation1.95860298
26MP0003075_altered_response_to1.90707417
27MP0004885_abnormal_endolymph1.87738738
28MP0001486_abnormal_startle_reflex1.85598060
29MP0008569_lethality_at_weaning1.84480922
30MP0004036_abnormal_muscle_relaxation1.84101405
31MP0004811_abnormal_neuron_physiology1.82177925
32MP0001968_abnormal_touch/_nociception1.81564896
33MP0005423_abnormal_somatic_nervous1.81307638
34MP0000751_myopathy1.81082121
35MP0002272_abnormal_nervous_system1.81010709
36MP0004130_abnormal_muscle_cell1.79233999
37MP0009278_abnormal_bone_marrow1.74870661
38MP0000749_muscle_degeneration1.69897453
39MP0002249_abnormal_larynx_morphology1.68630306
40MP0000759_abnormal_skeletal_muscle1.63858750
41MP0002933_joint_inflammation1.63566893
42MP0002734_abnormal_mechanical_nocicepti1.63192364
43MP0001501_abnormal_sleep_pattern1.62976785
44MP0003633_abnormal_nervous_system1.59884023
45MP0002733_abnormal_thermal_nociception1.57338772
46MP0000604_amyloidosis1.50464955
47MP0005167_abnormal_blood-brain_barrier1.49074081
48MP0003705_abnormal_hypodermis_morpholog1.47833670
49MP0005409_darkened_coat_color1.47520397
50MP0004947_skin_inflammation1.45399867
51MP0006082_CNS_inflammation1.44464504
52MP0000733_abnormal_muscle_development1.44148160
53MP0005330_cardiomyopathy1.43850563
54MP0000013_abnormal_adipose_tissue1.43455987
55MP0001440_abnormal_grooming_behavior1.42902709
56MP0000955_abnormal_spinal_cord1.42687044
57MP0003724_increased_susceptibility_to1.42261378
58MP0004185_abnormal_adipocyte_glucose1.41999520
59MP0003763_abnormal_thymus_physiology1.40946652
60MP0000678_abnormal_parathyroid_gland1.40000328
61MP0006138_congestive_heart_failure1.39461876
62MP0003879_abnormal_hair_cell1.38688204
63MP0003566_abnormal_cell_adhesion1.38092818
64MP0003690_abnormal_glial_cell1.36768645
65MP0001970_abnormal_pain_threshold1.36167661
66MP0004084_abnormal_cardiac_muscle1.33194279
67MP0003091_abnormal_cell_migration1.31601831
68MP0009840_abnormal_foam_cell1.30439551
69MP0004924_abnormal_behavior1.29188869
70MP0005386_behavior/neurological_phenoty1.29188869
71MP0008874_decreased_physiological_sensi1.28664311
72MP0002557_abnormal_social/conspecific_i1.28452716
73MP0002998_abnormal_bone_remodeling1.27318347
74MP0003646_muscle_fatigue1.26273748
75MP0002106_abnormal_muscle_physiology1.25928115
76MP0003453_abnormal_keratinocyte_physiol1.24748228
77MP0002067_abnormal_sensory_capabilities1.24442136
78MP0002736_abnormal_nociception_after1.22121998
79MP0000750_abnormal_muscle_regeneration1.20323197
80MP0004510_myositis1.19799448
81MP0000747_muscle_weakness1.18900924
82MP0001533_abnormal_skeleton_physiology1.18306022
83MP0010630_abnormal_cardiac_muscle1.17588315
84MP0005025_abnormal_response_to1.17162765
85MP0003631_nervous_system_phenotype1.16328832
86MP0002419_abnormal_innate_immunity1.16297720
87MP0002066_abnormal_motor_capabilities/c1.15780984
88MP0002332_abnormal_exercise_endurance1.11241343
89MP0005503_abnormal_tendon_morphology1.11121875
90MP0005369_muscle_phenotype1.10729009
91MP0002184_abnormal_innervation1.08245431
92MP0000767_abnormal_smooth_muscle1.08136744
93MP0009384_cardiac_valve_regurgitation1.08062283
94MP0003045_fibrosis1.08009195
95MP0004381_abnormal_hair_follicle1.06913225
96MP0002108_abnormal_muscle_morphology1.05647642
97MP0001873_stomach_inflammation1.05578241
98MP0002735_abnormal_chemical_nociception1.05118284
99MP0002089_abnormal_postnatal_growth/wei1.04711680
100MP0003787_abnormal_imprinting1.04405236
101MP0000858_altered_metastatic_potential1.04355364
102MP0004233_abnormal_muscle_weight1.02697561
103MP0002882_abnormal_neuron_morphology1.01594649
104MP0005623_abnormal_meninges_morphology1.00472807
105MP0004145_abnormal_muscle_electrophysio1.00426319
106MP0002269_muscular_atrophy0.98800521
107MP0005000_abnormal_immune_tolerance0.98154968
108MP0001851_eye_inflammation0.97382273
109MP0005535_abnormal_body_temperature0.96953094
110MP0000685_abnormal_immune_system0.96427601
111MP0000778_abnormal_nervous_system0.95795902
112MP0003634_abnormal_glial_cell0.95661627
113MP0003300_gastrointestinal_ulcer0.94656761
114MP0000003_abnormal_adipose_tissue0.94361291
115MP0005275_abnormal_skin_tensile0.94168374
116MP0001502_abnormal_circadian_rhythm0.93025366
117MP0005387_immune_system_phenotype0.92209697
118MP0001790_abnormal_immune_system0.92209697
119MP0005646_abnormal_pituitary_gland0.90668429
120* MP0002152_abnormal_brain_morphology0.89732949
121MP0005023_abnormal_wound_healing0.89667499
122MP0001800_abnormal_humoral_immune0.89477577
123MP0003183_abnormal_peptide_metabolism0.89196373
124MP0005620_abnormal_muscle_contractility0.89175842
125MP0009333_abnormal_splenocyte_physiolog0.88804392
126MP0003303_peritoneal_inflammation0.88784886
127MP0010329_abnormal_lipoprotein_level0.87754555
128MP0010155_abnormal_intestine_physiology0.87420554
129MP0002653_abnormal_ependyma_morphology0.87379024
130MP0003828_pulmonary_edema0.87062407
131MP0008872_abnormal_physiological_respon0.86221234
132MP0002069_abnormal_eating/drinking_beha0.84747326
133MP0002254_reproductive_system_inflammat0.84347041
134MP0002971_abnormal_brown_adipose0.84183031
135MP0005058_abnormal_lysosome_morphology0.81861560
136MP0002972_abnormal_cardiac_muscle0.80420100
137MP0002420_abnormal_adaptive_immunity0.80353941
138MP0005375_adipose_tissue_phenotype0.80124199
139MP0002723_abnormal_immune_serum0.80102912
140MP0005390_skeleton_phenotype0.80086230
141MP0001819_abnormal_immune_cell0.79768872
142MP0002229_neurodegeneration0.78405429
143MP0003632_abnormal_nervous_system0.77636901
144MP0004085_abnormal_heartbeat0.76088835
145MP0000920_abnormal_myelination0.74621723
146MP0000249_abnormal_blood_vessel0.73398293
147MP0003191_abnormal_cellular_cholesterol0.72768718
148MP0005166_decreased_susceptibility_to0.72182697
149MP0002234_abnormal_pharynx_morphology0.72134189
150MP0002837_dystrophic_cardiac_calcinosis0.71506712
151MP0001348_abnormal_lacrimal_gland0.68325096
152MP0003252_abnormal_bile_duct0.67655001
153MP0002090_abnormal_vision0.67482938
154MP0003137_abnormal_impulse_conducting0.67466289
155MP0005076_abnormal_cell_differentiation0.67454173
156MP0002078_abnormal_glucose_homeostasis0.64926263
157MP0004087_abnormal_muscle_fiber0.64383695
158MP0002118_abnormal_lipid_homeostasis0.62164267
159MP0001765_abnormal_ion_homeostasis0.61376268
160MP0005670_abnormal_white_adipose0.60073490
161MP0001984_abnormal_olfaction0.59347687
162MP0005666_abnormal_adipose_tissue0.59290410
163MP0001849_ear_inflammation0.59289302
164MP0002877_abnormal_melanocyte_morpholog0.58845759

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.01287989
2Visual hallucinations (HP:0002367)4.38419640
3Abnormality of the lower motor neuron (HP:0002366)4.19008275
4Focal motor seizures (HP:0011153)4.14676775
5Focal seizures (HP:0007359)3.97901659
6Type 1 muscle fiber predominance (HP:0003803)3.91036077
7Increased connective tissue (HP:0009025)3.71076400
8Supranuclear gaze palsy (HP:0000605)3.52024546
9Action tremor (HP:0002345)3.49868129
10Increased variability in muscle fiber diameter (HP:0003557)3.45270957
11Postural instability (HP:0002172)3.34615241
12Ankle clonus (HP:0011448)3.33557661
13Hemiplegia (HP:0002301)3.33063772
14Centrally nucleated skeletal muscle fibers (HP:0003687)3.27442256
15Abnormality of skeletal muscle fiber size (HP:0012084)3.26948907
16Cerebral aneurysm (HP:0004944)3.22916136
17Myopathic facies (HP:0002058)3.16063130
18Insomnia (HP:0100785)3.14498314
19Depression (HP:0000716)3.11141055
20Distal lower limb amyotrophy (HP:0008944)3.02320420
21Eczematoid dermatitis (HP:0000976)3.00686495
22Hyperacusis (HP:0010780)2.99408695
23Upper limb amyotrophy (HP:0009129)2.97798931
24Distal upper limb amyotrophy (HP:0007149)2.97798931
25Muscle fiber inclusion bodies (HP:0100299)2.96704143
26Distal lower limb muscle weakness (HP:0009053)2.92779909
27Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.89140216
28Broad face (HP:0000283)2.88947087
29Muscle fiber splitting (HP:0003555)2.87459946
30Round ear (HP:0100830)2.85042550
31Protrusio acetabuli (HP:0003179)2.83052877
32Abnormal social behavior (HP:0012433)2.80908597
33Impaired social interactions (HP:0000735)2.80908597
34Nemaline bodies (HP:0003798)2.79103513
35Dysmetric saccades (HP:0000641)2.76569749
36Papilledema (HP:0001085)2.74130332
37Mildly elevated creatine phosphokinase (HP:0008180)2.71520995
38Hand muscle atrophy (HP:0009130)2.71340889
39Urinary bladder sphincter dysfunction (HP:0002839)2.69804239
40Annular pancreas (HP:0001734)2.69439909
41Asymmetric septal hypertrophy (HP:0001670)2.68472598
42Stridor (HP:0010307)2.68268467
43Resting tremor (HP:0002322)2.67909560
44Poor eye contact (HP:0000817)2.67847909
45Bundle branch block (HP:0011710)2.67385679
46Impaired vibration sensation in the lower limbs (HP:0002166)2.66633999
47Pointed chin (HP:0000307)2.59629870
48Elfin facies (HP:0004428)2.58390587
49Mutism (HP:0002300)2.56510628
50Urinary urgency (HP:0000012)2.54985025
51Hyporeflexia of lower limbs (HP:0002600)2.51330968
52Difficulty climbing stairs (HP:0003551)2.47450428
53Torticollis (HP:0000473)2.46658012
54Intention tremor (HP:0002080)2.46550767
55Ulnar deviation of the wrist (HP:0003049)2.46275584
56Cerebral inclusion bodies (HP:0100314)2.43320975
57Ventricular fibrillation (HP:0001663)2.41327102
58Impaired smooth pursuit (HP:0007772)2.39653945
59Cervical subluxation (HP:0003308)2.38666653
60Thin bony cortex (HP:0002753)2.36292626
61Bradykinesia (HP:0002067)2.34762554
62Epileptic encephalopathy (HP:0200134)2.34409507
63Progressive cerebellar ataxia (HP:0002073)2.33813016
64Neoplasm of the heart (HP:0100544)2.33573266
65Generalized tonic-clonic seizures (HP:0002069)2.31743590
66Macroorchidism (HP:0000053)2.31218482
67Rapidly progressive (HP:0003678)2.29860737
68Turricephaly (HP:0000262)2.29257502
69Dysdiadochokinesis (HP:0002075)2.29118542
70Status epilepticus (HP:0002133)2.28891974
71Spastic gait (HP:0002064)2.28553463
72Abnormality of ocular smooth pursuit (HP:0000617)2.26119895
73Increased IgE level (HP:0003212)2.26012656
74Anxiety (HP:0000739)2.26003881
75Spinal rigidity (HP:0003306)2.24043696
76Dysmetria (HP:0001310)2.23694850
77Neuronal loss in central nervous system (HP:0002529)2.20973732
78Focal dystonia (HP:0004373)2.18621951
79Ulnar bowing (HP:0003031)2.16998713
80Bulbar palsy (HP:0001283)2.16627951
81Lymphangioma (HP:0100764)2.16267508
82Absence seizures (HP:0002121)2.16156359
83Easy fatigability (HP:0003388)2.15780460
84Genetic anticipation (HP:0003743)2.14657473
85Premature rupture of membranes (HP:0001788)2.14570646
86Atonic seizures (HP:0010819)2.14367730
87Clonus (HP:0002169)2.13157854
88Mitral regurgitation (HP:0001653)2.12300991
89Colitis (HP:0002583)2.11801593
90Neurofibrillary tangles (HP:0002185)2.10558266
91Gingivitis (HP:0000230)2.10422602
92Fragile skin (HP:0001030)2.10413676
93Aneurysm (HP:0002617)2.10004038
94EMG: myopathic abnormalities (HP:0003458)2.09942153
95Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.07764805
96Truncal ataxia (HP:0002078)2.06905595
97Hemiparesis (HP:0001269)2.06475334
98Lower limb amyotrophy (HP:0007210)2.06370971
99Craniofacial dystonia (HP:0012179)2.04220144
100Renovascular hypertension (HP:0100817)2.02851691
101Abnormality of the periventricular white matter (HP:0002518)2.02171961
102Metaphyseal cupping (HP:0003021)2.01597395
103Slender build (HP:0001533)2.01472877
104Obstructive sleep apnea (HP:0002870)2.01374521
105Achilles tendon contracture (HP:0001771)2.01224924
106Enlarged penis (HP:0000040)2.00488911
107Abnormal eating behavior (HP:0100738)2.00163096
108J-shaped sella turcica (HP:0002680)2.00096805
109Dialeptic seizures (HP:0011146)1.99097837
110Febrile seizures (HP:0002373)1.98634595
111Hemorrhage of the eye (HP:0011885)1.98151189
112Apathy (HP:0000741)1.97922158
113Lower limb muscle weakness (HP:0007340)1.97534354
114Biconcave vertebral bodies (HP:0004586)1.97239326
115Ventricular tachycardia (HP:0004756)1.97226970
116Dysostosis multiplex (HP:0000943)1.96746202
117Abnormality of the Achilles tendon (HP:0005109)1.95987100
118Broad metatarsal (HP:0001783)1.95799188
119Cellulitis (HP:0100658)1.93835785
120Striae distensae (HP:0001065)1.93018312
121Amyotrophic lateral sclerosis (HP:0007354)1.92471317
122Atrophic scars (HP:0001075)1.90264040
123Emphysema (HP:0002097)1.89499751
124Polygenic inheritance (HP:0010982)1.88323007
125Gaze-evoked nystagmus (HP:0000640)1.87686878
126Scanning speech (HP:0002168)1.87333152
127Dilatation of the ascending aorta (HP:0005111)1.86789184
128Difficulty running (HP:0009046)1.86755472
129Megalencephaly (HP:0001355)1.86676487
130Neck muscle weakness (HP:0000467)1.85696592
131Impaired vibratory sensation (HP:0002495)1.85575144
132Rigidity (HP:0002063)1.84921653
133Diplopia (HP:0000651)1.84763389
134Abnormality of binocular vision (HP:0011514)1.84763389
135Joint stiffness (HP:0001387)1.83787965
136Muscle stiffness (HP:0003552)1.82425522
137Stereotypic behavior (HP:0000733)1.81174065
138Recurrent gram-negative bacterial infections (HP:0005420)1.80886119
139Bronchomalacia (HP:0002780)1.80450864
140Sudden death (HP:0001699)1.80110411
141Foot dorsiflexor weakness (HP:0009027)1.79969715
142Aortic aneurysm (HP:0004942)1.79616754
143Long toe (HP:0010511)1.79184611
144Onion bulb formation (HP:0003383)1.78955630
145Overriding aorta (HP:0002623)1.78938779
146Hypercortisolism (HP:0001578)1.78769422
147Diminished motivation (HP:0000745)1.78343228
148Abnormality of the astrocytes (HP:0100707)1.77525136
149Astrocytoma (HP:0009592)1.77525136
150Distal arthrogryposis (HP:0005684)1.76473526
151Abnormality of polysaccharide metabolism (HP:0011012)1.75985935
152Abnormality of glycosaminoglycan metabolism (HP:0004371)1.75985935
153Abnormality of mucopolysaccharide metabolism (HP:0011020)1.75985935
154Mucopolysacchariduria (HP:0008155)1.75810000
155Urinary glycosaminoglycan excretion (HP:0003541)1.75810000
156Shallow orbits (HP:0000586)1.75399873
157Axonal loss (HP:0003447)1.75327427
158Global brain atrophy (HP:0002283)1.75157109
159Tetraplegia (HP:0002445)1.75014955
160Exercise-induced myalgia (HP:0003738)1.74644325
161Disproportionate tall stature (HP:0001519)1.73844875
162EMG: neuropathic changes (HP:0003445)1.73779527
163Gastrointestinal inflammation (HP:0004386)1.73412875
164Retinal atrophy (HP:0001105)1.73006291
165Malnutrition (HP:0004395)1.72042025
166Aortic regurgitation (HP:0001659)1.71551277
167Nuclear cataract (HP:0100018)1.70723016
168Abnormality of macrophages (HP:0004311)1.70655815
169Lower limb asymmetry (HP:0100559)1.70517000
170Hypertriglyceridemia (HP:0002155)1.70384678
171Amblyopia (HP:0000646)1.69147184
172Abnormality of the fingertips (HP:0001211)1.68766844
173Mitral valve prolapse (HP:0001634)1.68677791
174Abnormality of the foot musculature (HP:0001436)1.67480000
175Vertebral compression fractures (HP:0002953)1.67182155
176Atelectasis (HP:0100750)1.66675129
177Spinal canal stenosis (HP:0003416)1.65837826
178Abnormality of the nasal mucosa (HP:0000433)1.65045371
179Recurrent abscess formation (HP:0002722)1.64927295
180Blue sclerae (HP:0000592)1.64527458

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.54964696
2PRKD32.96574089
3EPHA42.95479727
4NTRK32.85773925
5PRPF4B2.85728516
6TRIB32.82771837
7DAPK22.58707034
8KSR22.57155528
9MAP4K12.19230841
10MAP2K32.13564858
11CAMKK12.10139077
12SMG12.07042759
13MARK11.99341836
14PAK61.96095500
15RIPK11.92090381
16NTRK11.87644680
17PKN21.85683053
18SIK21.81129039
19MINK11.81006980
20EPHB11.80409588
21NTRK21.78049695
22EEF2K1.65909902
23MAP3K131.64846825
24TYRO31.63271041
25MAP3K41.61994714
26STK381.61658882
27MAP3K111.54045460
28ICK1.47752631
29MAP3K61.43955546
30LMTK21.39418826
31TAOK11.38158476
32DAPK11.37997713
33PRKCH1.33624803
34PDGFRA1.33494466
35MAP2K41.32775906
36OBSCN1.30053171
37ZAP701.30039640
38CAMK1G1.29038268
39TYK21.23198781
40RET1.23073573
41ALK1.22259812
42CDK51.18733935
43PHKG21.16536663
44PHKG11.16536663
45RIPK41.13855533
46SCYL21.10387208
47MAP3K21.09121895
48KSR11.08813228
49MAP3K31.06365612
50STK111.03952151
51TBK11.03633869
52CSK0.98597834
53MAP3K70.97883709
54FES0.97396971
55CAMK10.96360839
56NEK10.96074111
57BLK0.95827227
58CAMKK20.95817092
59MARK20.95672936
60EPHA20.94094098
61PTK60.91279229
62RPS6KL10.87963354
63RPS6KC10.87963354
64MAPK70.87950201
65CDK120.87232210
66TGFBR20.85892307
67MAP3K10.85379847
68UHMK10.85335618
69ERN10.84789657
70GRK60.83796822
71DYRK1B0.82972042
72PDK10.82940187
73SGK30.82865408
74PINK10.80948334
75TESK10.79615210
76LATS20.78066052
77ARAF0.77667260
78CAMK40.74299890
79PDPK10.73881910
80GRK50.73391869
81TAOK20.73307118
82IRAK30.69753796
83CDC42BPA0.69469704
84CAMK1D0.69288134
85BTK0.69159550
86SIK10.67802526
87RPS6KA60.67577494
88MAP3K100.66560611
89MST1R0.66509288
90MAPK150.66323324
91MAPKAPK30.66255457
92SIK30.66194879
93DDR20.65923304
94PNCK0.65270534
95BMX0.61947931
96HCK0.61684295
97MAPK110.60763379
98RPS6KA20.60685585
99TTN0.60350496
100PRKD20.60101130
101JAK30.60051906
102RAF10.58022298
103PRKCG0.57535529
104IRAK40.57388265
105PTK20.55677873
106CDK150.55069797
107PAK30.54576007
108MAPK40.54316708
109MAP2K60.53927984
110DAPK30.52976405
111PDGFRB0.52729246
112MAPK120.52558776
113FGFR30.52287475
114PTK2B0.49880195
115TNK20.49462097
116DMPK0.49331358
117MAP2K20.49023352
118FYN0.48854636
119CDK180.48837948
120RPS6KA30.48664225
121JAK20.48462374
122FGFR40.47137453
123SGK4940.47034762
124SGK2230.47034762
125CDK11A0.46971809
126MTOR0.46498408
127JAK10.46365629
128PRKD10.45901251
129PRKCZ0.45175705
130PRKG20.44532452
131MAP3K140.43804057
132SGK10.43276469
133HIPK20.42390832
134EPHA30.41676075
135CDK140.40735563
136MATK0.40680545
137FGFR20.40638615
138FGR0.40287182
139SGK20.39994318
140ITK0.39566162
141PRKAA20.38921706
142LCK0.38273954
143MAPK100.35817929

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.74451075
2Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.43405633
3Synaptic vesicle cycle_Homo sapiens_hsa047212.41728210
4Other glycan degradation_Homo sapiens_hsa005112.33138711
5Olfactory transduction_Homo sapiens_hsa047402.23259684
6Circadian entrainment_Homo sapiens_hsa047132.02689617
7Long-term potentiation_Homo sapiens_hsa047201.98995581
8Notch signaling pathway_Homo sapiens_hsa043301.90279767
9GABAergic synapse_Homo sapiens_hsa047271.87700124
10Aldosterone synthesis and secretion_Homo sapiens_hsa049251.85758979
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.81565881
12Nicotine addiction_Homo sapiens_hsa050331.79575913
13Glutamatergic synapse_Homo sapiens_hsa047241.77529293
14Insulin secretion_Homo sapiens_hsa049111.76450972
15Salivary secretion_Homo sapiens_hsa049701.73014050
16Gastric acid secretion_Homo sapiens_hsa049711.72487284
17Morphine addiction_Homo sapiens_hsa050321.66864404
18Amphetamine addiction_Homo sapiens_hsa050311.66817657
19Type II diabetes mellitus_Homo sapiens_hsa049301.58418111
20Acute myeloid leukemia_Homo sapiens_hsa052211.58125448
21Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.57654749
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.55067455
23Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.54180098
24Dopaminergic synapse_Homo sapiens_hsa047281.52645181
25Cholinergic synapse_Homo sapiens_hsa047251.49056189
26Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.48356072
27Osteoclast differentiation_Homo sapiens_hsa043801.43512411
28B cell receptor signaling pathway_Homo sapiens_hsa046621.40354613
29Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.37493822
30Oxytocin signaling pathway_Homo sapiens_hsa049211.37403531
31Estrogen signaling pathway_Homo sapiens_hsa049151.36039931
32Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.35542697
33GnRH signaling pathway_Homo sapiens_hsa049121.34025340
34Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.30326560
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.28426225
36Renin secretion_Homo sapiens_hsa049241.28143647
37Cocaine addiction_Homo sapiens_hsa050301.27484045
38Glioma_Homo sapiens_hsa052141.23589436
39Cyanoamino acid metabolism_Homo sapiens_hsa004601.18879847
40Bile secretion_Homo sapiens_hsa049761.18832827
41Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.17082782
42Carbohydrate digestion and absorption_Homo sapiens_hsa049731.14823940
43Leukocyte transendothelial migration_Homo sapiens_hsa046701.13960174
44AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.13151592
45Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.12194035
46mTOR signaling pathway_Homo sapiens_hsa041501.10041425
47Leishmaniasis_Homo sapiens_hsa051401.09307530
48Phospholipase D signaling pathway_Homo sapiens_hsa040721.09240758
49Calcium signaling pathway_Homo sapiens_hsa040201.07646998
50Gap junction_Homo sapiens_hsa045401.07003936
51cAMP signaling pathway_Homo sapiens_hsa040241.06784304
52Arginine biosynthesis_Homo sapiens_hsa002201.05139243
53Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.05010778
54Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.02041067
55Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.00465347
56Neurotrophin signaling pathway_Homo sapiens_hsa047220.98867172
57T cell receptor signaling pathway_Homo sapiens_hsa046600.98803017
58Long-term depression_Homo sapiens_hsa047300.95988680
592-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.95331740
60Staphylococcus aureus infection_Homo sapiens_hsa051500.94834958
61cGMP-PKG signaling pathway_Homo sapiens_hsa040220.93967737
62Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.93880670
63Dorso-ventral axis formation_Homo sapiens_hsa043200.93827478
64Toll-like receptor signaling pathway_Homo sapiens_hsa046200.92356489
65Fructose and mannose metabolism_Homo sapiens_hsa000510.91833044
66ErbB signaling pathway_Homo sapiens_hsa040120.90721741
67Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.90702538
68Thyroid hormone signaling pathway_Homo sapiens_hsa049190.89641498
69Viral myocarditis_Homo sapiens_hsa054160.89401372
70Pancreatic cancer_Homo sapiens_hsa052120.89259400
71Longevity regulating pathway - mammal_Homo sapiens_hsa042110.88633378
72Insulin signaling pathway_Homo sapiens_hsa049100.88139921
73Taste transduction_Homo sapiens_hsa047420.87819276
74Glucagon signaling pathway_Homo sapiens_hsa049220.87500349
75Toxoplasmosis_Homo sapiens_hsa051450.86992666
76VEGF signaling pathway_Homo sapiens_hsa043700.86652056
77Thyroid hormone synthesis_Homo sapiens_hsa049180.86381319
78Malaria_Homo sapiens_hsa051440.85677852
79Tuberculosis_Homo sapiens_hsa051520.83169023
80Melanogenesis_Homo sapiens_hsa049160.82668959
81TNF signaling pathway_Homo sapiens_hsa046680.80955293
82Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.79897759
83Hepatitis C_Homo sapiens_hsa051600.79042525
84Bladder cancer_Homo sapiens_hsa052190.78930832
85Prion diseases_Homo sapiens_hsa050200.78925196
86Dilated cardiomyopathy_Homo sapiens_hsa054140.77926367
87Central carbon metabolism in cancer_Homo sapiens_hsa052300.77694683
88Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.76313862
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.75321797
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.74100841
91Insulin resistance_Homo sapiens_hsa049310.74006470
92Endocytosis_Homo sapiens_hsa041440.73142524
93Choline metabolism in cancer_Homo sapiens_hsa052310.72995104
94ECM-receptor interaction_Homo sapiens_hsa045120.71887783
95Pancreatic secretion_Homo sapiens_hsa049720.71704449
96Pertussis_Homo sapiens_hsa051330.71617458
97Non-small cell lung cancer_Homo sapiens_hsa052230.71111391
98Endometrial cancer_Homo sapiens_hsa052130.66582018
99Inositol phosphate metabolism_Homo sapiens_hsa005620.65454472
100RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.65177349
101Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.65045470
102Rap1 signaling pathway_Homo sapiens_hsa040150.64885278
103Serotonergic synapse_Homo sapiens_hsa047260.62972526
104Lysosome_Homo sapiens_hsa041420.61399300
105MAPK signaling pathway_Homo sapiens_hsa040100.60542078
106Graft-versus-host disease_Homo sapiens_hsa053320.60345141
107FoxO signaling pathway_Homo sapiens_hsa040680.58978978
108Adipocytokine signaling pathway_Homo sapiens_hsa049200.58871657
109Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58687180
110Influenza A_Homo sapiens_hsa051640.57540346
111Axon guidance_Homo sapiens_hsa043600.56314214
112Lysine degradation_Homo sapiens_hsa003100.55858152
113Chronic myeloid leukemia_Homo sapiens_hsa052200.55543571
114HIF-1 signaling pathway_Homo sapiens_hsa040660.55516776
115AMPK signaling pathway_Homo sapiens_hsa041520.54809133
116HTLV-I infection_Homo sapiens_hsa051660.54568773
117NF-kappa B signaling pathway_Homo sapiens_hsa040640.54189812
118Hepatitis B_Homo sapiens_hsa051610.54132316
119Apoptosis_Homo sapiens_hsa042100.53311342
120Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.53038719
121Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52880810
122Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52717074
123Renal cell carcinoma_Homo sapiens_hsa052110.50915874
124Platelet activation_Homo sapiens_hsa046110.50389997
125Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50355293
126Butanoate metabolism_Homo sapiens_hsa006500.50164388
127Prolactin signaling pathway_Homo sapiens_hsa049170.48872641
128Fatty acid biosynthesis_Homo sapiens_hsa000610.45912730
129Oocyte meiosis_Homo sapiens_hsa041140.44937095
130Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.44544308
131Chemokine signaling pathway_Homo sapiens_hsa040620.44436655
132Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43128626
133Sphingolipid signaling pathway_Homo sapiens_hsa040710.39890537
134Glycosaminoglycan degradation_Homo sapiens_hsa005310.39431324
135Colorectal cancer_Homo sapiens_hsa052100.37921317
136Ras signaling pathway_Homo sapiens_hsa040140.37803568
137Proteoglycans in cancer_Homo sapiens_hsa052050.37599953
138Focal adhesion_Homo sapiens_hsa045100.36086682
139Glycerophospholipid metabolism_Homo sapiens_hsa005640.35986658
140Amoebiasis_Homo sapiens_hsa051460.35727591

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