MGRN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mahogunin (MGRN1) is a C3HC4 RING-containing protein with E3 ubiquitin ligase activity in vitro. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)4.52936070
2cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.41186805
3locomotory exploration behavior (GO:0035641)4.23166933
4synaptic vesicle docking involved in exocytosis (GO:0016081)4.15595866
5regulation of short-term neuronal synaptic plasticity (GO:0048172)4.13966989
6mannose metabolic process (GO:0006013)4.07733504
7cell communication by electrical coupling (GO:0010644)4.04416499
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.96787565
9regulation of synapse structural plasticity (GO:0051823)3.95993716
10negative regulation of erythrocyte differentiation (GO:0045647)3.91055122
11synaptic vesicle exocytosis (GO:0016079)3.81597112
12glutamate secretion (GO:0014047)3.79221444
13vocalization behavior (GO:0071625)3.75309135
14negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.72442830
15negative regulation of cell killing (GO:0031342)3.72442830
16modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.68059707
17positive regulation by organism of defense response of other organism involved in symbiotic interact3.68059707
18modulation by symbiont of host immune response (GO:0052553)3.68059707
19positive regulation by symbiont of host defense response (GO:0052509)3.68059707
20modulation by symbiont of host defense response (GO:0052031)3.68059707
21modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.68059707
22membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.67726894
23activation of protein kinase A activity (GO:0034199)3.61681225
24sodium ion export (GO:0071436)3.59989844
25positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.54952809
26cardiac myofibril assembly (GO:0055003)3.48369220
27regulation of synaptic vesicle exocytosis (GO:2000300)3.46269758
28regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.41627950
29regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.37870320
30cell communication involved in cardiac conduction (GO:0086065)3.37288515
31regulation of glutamate receptor signaling pathway (GO:1900449)3.31787862
32regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.31358239
33regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.30895797
34neurotransmitter secretion (GO:0007269)3.27493625
35tricarboxylic acid cycle (GO:0006099)3.27065230
36cellular potassium ion homeostasis (GO:0030007)3.25757531
37antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.24196447
38positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.20935306
39cardiac muscle contraction (GO:0060048)3.20548002
40negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.20392386
41negative regulation of potassium ion transmembrane transport (GO:1901380)3.20241091
42potassium ion import (GO:0010107)3.19609348
43macrophage activation involved in immune response (GO:0002281)3.19114139
44response to muramyl dipeptide (GO:0032495)3.15334590
45regulation of synaptic vesicle transport (GO:1902803)3.14866296
46plasma membrane repair (GO:0001778)3.14627812
47sarcomere organization (GO:0045214)3.13691672
48regulation of membrane repolarization (GO:0060306)3.13233628
49antigen processing and presentation of endogenous antigen (GO:0019883)3.09203057
50proline transport (GO:0015824)3.08291585
51regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.05278501
52exploration behavior (GO:0035640)3.05174763
53antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.00199867
54regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.99847046
55cell-cell junction maintenance (GO:0045217)2.99824982
56regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.97904141
57NADH metabolic process (GO:0006734)2.97720001
58response to peptidoglycan (GO:0032494)2.96847706
59positive regulation of gamma-delta T cell activation (GO:0046645)2.96139445
60regulation of ARF GTPase activity (GO:0032312)2.96125016
61gamma-aminobutyric acid transport (GO:0015812)2.93750515
62neurotransmitter-gated ion channel clustering (GO:0072578)2.93281011
63positive regulation of synapse maturation (GO:0090129)2.91724571
64regulation of neuronal synaptic plasticity (GO:0048168)2.90956742
65antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.90086792
66positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.89887311
67layer formation in cerebral cortex (GO:0021819)2.87196120
68positive regulation of histone deacetylation (GO:0031065)2.86902104
69detection of bacterium (GO:0016045)2.84233038
70detection of other organism (GO:0098543)2.84122946
71membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.81797654
72regulation of long-term neuronal synaptic plasticity (GO:0048169)2.79914439
73neuronal action potential propagation (GO:0019227)2.78927200
74negative regulation of cytosolic calcium ion concentration (GO:0051481)2.77564480
75establishment of nucleus localization (GO:0040023)2.76533528
76regulation of calcium ion transmembrane transporter activity (GO:1901019)2.74874625
77regulation of calcium ion transmembrane transport (GO:1903169)2.74874625
78regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.74575712
79myofibril assembly (GO:0030239)2.72474517
80protein localization to synapse (GO:0035418)2.72391620
81regulation of ARF protein signal transduction (GO:0032012)2.71608541
82alanine transport (GO:0032328)2.71602775
83regulation of gamma-delta T cell activation (GO:0046643)2.70740201
84cardiac muscle hypertrophy (GO:0003300)2.69583524
85cardiac conduction (GO:0061337)2.67628820
86neuromuscular process controlling posture (GO:0050884)2.67283444
87positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.67200101
88positive regulation of potassium ion transmembrane transport (GO:1901381)2.67105266
89cerebellar Purkinje cell layer development (GO:0021680)2.66806048
90positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.66073754
91detection of calcium ion (GO:0005513)2.65723112
92ionotropic glutamate receptor signaling pathway (GO:0035235)2.65663013
93regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.64916739
94germinal center formation (GO:0002467)2.63415160
95ventricular cardiac muscle cell action potential (GO:0086005)2.63045084
96semaphorin-plexin signaling pathway (GO:0071526)2.62789887
97positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.62256207
98regulation of T-helper 2 cell differentiation (GO:0045628)2.61768487
99positive thymic T cell selection (GO:0045059)2.61414958
100regulation of actin filament-based movement (GO:1903115)2.61284865
101cellular sodium ion homeostasis (GO:0006883)2.61228589
102membrane repolarization (GO:0086009)2.59968488
103positive regulation of sodium ion transport (GO:0010765)2.59863778
104succinate metabolic process (GO:0006105)2.58479247
105protein localization to endosome (GO:0036010)2.57670572
106detection of external biotic stimulus (GO:0098581)2.57648596
107glycine transport (GO:0015816)2.57399999
108striated muscle hypertrophy (GO:0014897)2.57059000
109synaptic transmission, glutamatergic (GO:0035249)2.55314894
110detection of molecule of bacterial origin (GO:0032490)2.53936534
111potassium ion homeostasis (GO:0055075)2.53168545
112regulation of leukocyte degranulation (GO:0043300)2.52918727
113relaxation of cardiac muscle (GO:0055119)2.52410824
114long-term memory (GO:0007616)2.52278104
115signal complex assembly (GO:0007172)2.51033642
116neuromuscular process controlling balance (GO:0050885)2.50630681
117regulation of acyl-CoA biosynthetic process (GO:0050812)2.49927255
118membrane repolarization during action potential (GO:0086011)2.48068116
119negative regulation of toll-like receptor signaling pathway (GO:0034122)2.47973500
120neurotransmitter transport (GO:0006836)2.47870723
121membrane depolarization during action potential (GO:0086010)2.47529059
122regulation of heart rate by cardiac conduction (GO:0086091)2.46989048
123thymic T cell selection (GO:0045061)2.46446477
124regulation of myeloid leukocyte mediated immunity (GO:0002886)2.45630281
125dendritic spine morphogenesis (GO:0060997)2.44778395
126synaptic vesicle endocytosis (GO:0048488)2.44256099
127cardiac muscle adaptation (GO:0014887)2.43912769
128cardiac muscle hypertrophy in response to stress (GO:0014898)2.43912769
129muscle hypertrophy in response to stress (GO:0003299)2.43912769
130regulation of cell communication by electrical coupling (GO:0010649)2.43884693
131positive regulation of CREB transcription factor activity (GO:0032793)2.43655832
132regulation of voltage-gated calcium channel activity (GO:1901385)2.43357889
133positive regulation of Rap GTPase activity (GO:0032854)2.43074399
134intracellular estrogen receptor signaling pathway (GO:0030520)2.42653196
135regulation of gamma-delta T cell differentiation (GO:0045586)2.42430121
136regulation of NFAT protein import into nucleus (GO:0051532)2.41674823
137regulation of ion transmembrane transporter activity (GO:0032412)2.41613901
138G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.41198852
139negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.39437380
140regulation of the force of heart contraction (GO:0002026)2.39112611
141stress fiber assembly (GO:0043149)2.38975368
142regulation of regulated secretory pathway (GO:1903305)2.38872554
143regulation of excitatory postsynaptic membrane potential (GO:0060079)2.38571135
144neuron-neuron synaptic transmission (GO:0007270)2.38283712
145regulation of mast cell degranulation (GO:0043304)2.37074702
146regulation of cofactor metabolic process (GO:0051193)2.36658227
147regulation of interferon-beta biosynthetic process (GO:0045357)2.36377951
148positive regulation of protein deacetylation (GO:0090312)2.36183038
149activation of MAPKKK activity (GO:0000185)2.34587399
150modulation by symbiont of host cellular process (GO:0044068)2.33064456
151modulation by virus of host process (GO:0019054)2.32574989
152response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.31886104
153response to host (GO:0075136)2.31886104
154response to host defenses (GO:0052200)2.31886104
155detection of biotic stimulus (GO:0009595)2.30023415
156response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.29291940
157response to host immune response (GO:0052572)2.29291940
158leukocyte aggregation (GO:0070486)2.28996786
159positive regulation of cellular amide metabolic process (GO:0034250)2.28394560
160activation of JUN kinase activity (GO:0007257)2.27280031
161regulation of early endosome to late endosome transport (GO:2000641)2.26225714
162cytoskeletal anchoring at plasma membrane (GO:0007016)2.25941342
163activation of Rac GTPase activity (GO:0032863)2.25777234
164peptidyl-tyrosine autophosphorylation (GO:0038083)2.25622795
165negative regulation of interleukin-12 production (GO:0032695)2.24939592
166cellular extravasation (GO:0045123)2.24777660
167negative regulation of fatty acid transport (GO:2000192)2.23996300
168negative regulation of lymphocyte mediated immunity (GO:0002707)2.23817741
169positive regulation of protein dephosphorylation (GO:0035307)2.23708233
170negative regulation of leukocyte mediated immunity (GO:0002704)2.23562941
171positive regulation of Cdc42 GTPase activity (GO:0043089)2.22257204
172response to laminar fluid shear stress (GO:0034616)2.21959171
173regulation of extracellular matrix disassembly (GO:0010715)2.20349071
174adherens junction assembly (GO:0034333)2.20166072
175cell migration in hindbrain (GO:0021535)2.19238348
176immunoglobulin mediated immune response (GO:0016064)2.18870291
177cell junction maintenance (GO:0034331)2.17973173
178negative regulation of granulocyte differentiation (GO:0030853)2.17640582
179B cell receptor signaling pathway (GO:0050853)2.15083866
180negative regulation of cell size (GO:0045792)2.14470842
181cell-substrate adherens junction assembly (GO:0007045)2.13049085
182focal adhesion assembly (GO:0048041)2.13049085
183lipopolysaccharide-mediated signaling pathway (GO:0031663)2.11443048
184positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.10522161
185regulation of macrophage cytokine production (GO:0010935)2.09843769
186apoptotic process involved in morphogenesis (GO:0060561)2.09369796
187negative regulation of glial cell proliferation (GO:0060253)2.08283291
188regulation of defense response to virus by virus (GO:0050690)2.08246436
189cerebellar granule cell differentiation (GO:0021707)2.07924210
190histone H3-K36 demethylation (GO:0070544)2.07425911
191regulation of mast cell activation involved in immune response (GO:0033006)2.07031793
192negative regulation of myotube differentiation (GO:0010832)2.04971007
193T cell selection (GO:0045058)2.03764564
194macrophage activation (GO:0042116)2.03412644
195barbed-end actin filament capping (GO:0051016)2.02672045
196regulation of phosphatidylinositol 3-kinase activity (GO:0043551)2.02168387

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.80496253
2VDR_21846776_ChIP-Seq_THP-1_Human2.82161180
3DROSHA_22980978_ChIP-Seq_HELA_Human2.59454451
4RARB_27405468_Chip-Seq_BRAIN_Mouse2.48741656
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.48682709
6MYC_22102868_ChIP-Seq_BL_Human2.48596422
7KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.41582914
8TCF7_22412390_ChIP-Seq_EML_Mouse2.38880393
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.34213833
10MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.34007370
11ELK3_25401928_ChIP-Seq_HUVEC_Human2.27455668
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.20008951
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.20008951
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.17579154
15* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.17406782
16STAT6_21828071_ChIP-Seq_BEAS2B_Human2.15473637
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.09076952
18EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.99840425
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.99280237
20REST_21632747_ChIP-Seq_MESCs_Mouse1.98017256
21JARID2_20075857_ChIP-Seq_MESCs_Mouse1.97915639
22THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.95470802
23PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.94507416
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.93590085
25RACK7_27058665_Chip-Seq_MCF-7_Human1.92515113
26GBX2_23144817_ChIP-Seq_PC3_Human1.91690441
27VDR_24763502_ChIP-Seq_THP-1_Human1.91542283
28JARID2_20064375_ChIP-Seq_MESCs_Mouse1.90806302
29REST_18959480_ChIP-ChIP_MESCs_Mouse1.89754452
30SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.89139063
31EZH2_27294783_Chip-Seq_ESCs_Mouse1.88843249
32KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.87411374
33IKZF1_21737484_ChIP-ChIP_HCT116_Human1.80364120
34TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.80241601
35* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.78141870
36SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.77733076
37SUZ12_27294783_Chip-Seq_ESCs_Mouse1.76802670
38* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.74871802
39TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.73393733
40DNAJC2_21179169_ChIP-ChIP_NT2_Human1.68859003
41ERG_21242973_ChIP-ChIP_JURKAT_Human1.65335366
42ZFP281_18757296_ChIP-ChIP_E14_Mouse1.65183925
43EP300_21415370_ChIP-Seq_HL-1_Mouse1.64306069
44EZH2_27304074_Chip-Seq_ESCs_Mouse1.60692262
45* P68_20966046_ChIP-Seq_HELA_Human1.59864684
46EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.57895219
47MAF_26560356_Chip-Seq_TH1_Human1.56460768
48KDM2B_26808549_Chip-Seq_K562_Human1.55524688
49RNF2_27304074_Chip-Seq_ESCs_Mouse1.53280637
50CTCF_27219007_Chip-Seq_ERYTHROID_Human1.49897913
51WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.49557595
52KDM2B_26808549_Chip-Seq_SUP-B15_Human1.47463250
53* GATA1_19941827_ChIP-Seq_MEL_Mouse1.46972624
54RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.46324041
55TP63_17297297_ChIP-ChIP_HaCaT_Human1.46033939
56EED_16625203_ChIP-ChIP_MESCs_Mouse1.45850674
57UTX_26944678_Chip-Seq_JUKART_Human1.45171135
58SA1_27219007_Chip-Seq_ERYTHROID_Human1.45009185
59IRF8_22096565_ChIP-ChIP_GC-B_Human1.43765413
60STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.43597828
61LXR_22292898_ChIP-Seq_THP-1_Human1.42946573
62MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.40715232
63SPI1_23127762_ChIP-Seq_K562_Human1.38497331
64CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.37965082
65BP1_19119308_ChIP-ChIP_Hs578T_Human1.37751128
66TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.37574530
67NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.37209278
68GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.37048311
69RUNX1_22412390_ChIP-Seq_EML_Mouse1.36686875
70SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.36251389
71UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.36026517
72EGR1_19374776_ChIP-ChIP_THP-1_Human1.35367970
73WT1_25993318_ChIP-Seq_PODOCYTE_Human1.34674557
74MAF_26560356_Chip-Seq_TH2_Human1.32790760
75NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.29984918
76NR3C1_23031785_ChIP-Seq_PC12_Mouse1.26781509
77TET1_21451524_ChIP-Seq_MESCs_Mouse1.26129850
78DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.23184177
79TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.23044141
80ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.21897133
81ESR1_20079471_ChIP-ChIP_T-47D_Human1.20942980
82BRD4_27068464_Chip-Seq_AML-cells_Mouse1.20603685
83SCL_19346495_ChIP-Seq_HPC-7_Human1.20552964
84BCOR_27268052_Chip-Seq_Bcells_Human1.20206954
85ESR2_21235772_ChIP-Seq_MCF-7_Human1.19881797
86TBX20_22080862_ChIP-Seq_HEART_Mouse1.18736340
87TBX20_22328084_ChIP-Seq_HEART_Mouse1.18736340
88ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.18047074
89SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.17702420
90ELF1_20517297_ChIP-Seq_JURKAT_Human1.17341160
91SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.17159071
92BCL6_27268052_Chip-Seq_Bcells_Human1.16802085
93TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.16043836
94RARG_19884340_ChIP-ChIP_MEFs_Mouse1.15209496
95TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14957730
96* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.14600496
97SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.14346584
98* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.14096408
99PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.13774340
100CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13016758
101RUNX1_27514584_Chip-Seq_MCF-7_Human1.12612350
102CTCF_27219007_Chip-Seq_Bcells_Human1.12589529
103RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.12239774
104VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.11960613
105* SOX2_21211035_ChIP-Seq_LN229_Gbm1.10969470
106FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.10571278
107MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.10050840
108EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.09975513
109CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.09216436
110KDM2B_26808549_Chip-Seq_DND41_Human1.08457818
111RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.08250062
112SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07766727
113NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.07704561
114* AR_19668381_ChIP-Seq_PC3_Human1.07036355
115RING1B_27294783_Chip-Seq_ESCs_Mouse1.06934099
116ZNF274_21170338_ChIP-Seq_K562_Hela1.06774894
117AR_21572438_ChIP-Seq_LNCaP_Human1.05990285
118SRY_22984422_ChIP-ChIP_TESTIS_Rat1.05738935
119* OCT4_19829295_ChIP-Seq_ESCs_Human1.05655860
120* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.05273059
121MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.05154859
122* SMC4_20622854_ChIP-Seq_HELA_Human1.04713959
123* TP53_22127205_ChIP-Seq_IMR90_Human1.04593893
124PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04335552
125TET1_21490601_ChIP-Seq_MESCs_Mouse1.03267268
126TP63_22573176_ChIP-Seq_HFKS_Human1.01571528
127ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.01135984
128* LXR_22158963_ChIP-Seq_LIVER_Mouse1.00005737
129IRF8_27001747_Chip-Seq_BMDM_Mouse0.99301807
130SMAD4_21741376_ChIP-Seq_HESCs_Human0.99162887
131SA1_27219007_Chip-Seq_Bcells_Human0.98502910
132TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.97980967
133ZFP281_27345836_Chip-Seq_ESCs_Mouse0.97609801
134KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.97388996
135FOXA2_19822575_ChIP-Seq_HepG2_Human0.95903602
136FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.95641378
137* RXR_22158963_ChIP-Seq_LIVER_Mouse0.95432548
138AHR_22903824_ChIP-Seq_MCF-7_Human0.95344856
139GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.93889941
140ZNF217_24962896_ChIP-Seq_MCF-7_Human0.93720163
141SMAD3_21741376_ChIP-Seq_HESCs_Human0.93629134
142RUNX_20019798_ChIP-Seq_JUKART_Human0.93484223
143NCOR1_26117541_ChIP-Seq_K562_Human0.93248161
144ARNT_22903824_ChIP-Seq_MCF-7_Human0.91123534
145GATA1_19941826_ChIP-Seq_K562_Human0.90278902
146ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.89498353
147BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.89376535
148* KLF4_19829295_ChIP-Seq_ESCs_Human0.88274962
149SMAD4_21799915_ChIP-Seq_A2780_Human0.87454861
150CREB1_26743006_Chip-Seq_LNCaP_Human0.87189391
151CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.86500063
152CLOCK_20551151_ChIP-Seq_293T_Human0.85979476
153RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.85790918
154CTNNB1_20460455_ChIP-Seq_HCT116_Human0.84251098
155ZNF263_19887448_ChIP-Seq_K562_Human0.83121648
156RXR_22108803_ChIP-Seq_LS180_Human0.82996263
157OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.81322189
158TRIM28_21343339_ChIP-Seq_HEK293_Human0.81071496
159TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.80002776
160PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.79876232
161KDM2B_26808549_Chip-Seq_JURKAT_Human0.79408083

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.88888734
2MP0002837_dystrophic_cardiac_calcinosis4.36795286
3MP0003303_peritoneal_inflammation3.54128666
4MP0003436_decreased_susceptibility_to3.48354335
5MP0000751_myopathy3.35122010
6MP0003705_abnormal_hypodermis_morpholog3.14889019
7MP0003635_abnormal_synaptic_transmissio2.92138891
8MP0003646_muscle_fatigue2.72388949
9MP0004084_abnormal_cardiac_muscle2.72015856
10MP0004215_abnormal_myocardial_fiber2.64216770
11MP0009278_abnormal_bone_marrow2.62107964
12MP0005076_abnormal_cell_differentiation2.42836099
13MP0002909_abnormal_adrenal_gland2.41167563
14MP0003300_gastrointestinal_ulcer2.37407344
15MP0009745_abnormal_behavioral_response2.29835194
16MP0003880_abnormal_central_pattern2.29262080
17MP0004036_abnormal_muscle_relaxation2.27229904
18MP0002064_seizures2.24577382
19MP0002063_abnormal_learning/memory/cond2.23070623
20MP0004270_analgesia2.19790963
21MP0002822_catalepsy2.18780624
22MP0005409_darkened_coat_color2.08010180
23MP0009780_abnormal_chondrocyte_physiolo2.06803182
24MP0009840_abnormal_foam_cell2.02621683
25MP0009046_muscle_twitch2.01820270
26MP0000685_abnormal_immune_system1.98967127
27MP0005451_abnormal_body_composition1.98869546
28MP0004130_abnormal_muscle_cell1.97123068
29MP0002419_abnormal_innate_immunity1.94877773
30MP0005330_cardiomyopathy1.94728065
31MP0003724_increased_susceptibility_to1.91690165
32MP0000749_muscle_degeneration1.89504725
33MP0000013_abnormal_adipose_tissue1.87845096
34MP0001849_ear_inflammation1.87081027
35MP0004858_abnormal_nervous_system1.87064429
36MP0008260_abnormal_autophagy1.86241624
37MP0001790_abnormal_immune_system1.86012023
38MP0005387_immune_system_phenotype1.86012023
39MP0003137_abnormal_impulse_conducting1.82859997
40MP0003329_amyloid_beta_deposits1.81884535
41MP0005025_abnormal_response_to1.81089985
42MP0001348_abnormal_lacrimal_gland1.77319557
43MP0002972_abnormal_cardiac_muscle1.75857866
44MP0002572_abnormal_emotion/affect_behav1.75632432
45MP0004085_abnormal_heartbeat1.74232807
46MP0004510_myositis1.72046010
47MP0003091_abnormal_cell_migration1.69607881
48MP0004947_skin_inflammation1.68129150
49MP0001533_abnormal_skeleton_physiology1.67677962
50MP0004145_abnormal_muscle_electrophysio1.66807458
51MP0004087_abnormal_muscle_fiber1.66800965
52MP0005000_abnormal_immune_tolerance1.66234634
53MP0004043_abnormal_pH_regulation1.64307761
54MP0002272_abnormal_nervous_system1.64038286
55MP0001958_emphysema1.61805748
56MP0008569_lethality_at_weaning1.61802702
57MP0005620_abnormal_muscle_contractility1.59218713
58MP0001800_abnormal_humoral_immune1.58774234
59MP0004484_altered_response_of1.55171792
60MP0003279_aneurysm1.54566580
61MP0001835_abnormal_antigen_presentation1.52734130
62MP0008961_abnormal_basal_metabolism1.52721428
63MP0002998_abnormal_bone_remodeling1.50683572
64MP0001968_abnormal_touch/_nociception1.50406737
65MP0008775_abnormal_heart_ventricle1.47159986
66MP0002249_abnormal_larynx_morphology1.43004765
67MP0005671_abnormal_response_to1.42957470
68MP0002269_muscular_atrophy1.42690940
69MP0001501_abnormal_sleep_pattern1.42217792
70MP0002723_abnormal_immune_serum1.42191715
71MP0001486_abnormal_startle_reflex1.41222368
72MP0003191_abnormal_cellular_cholesterol1.40791565
73MP0004233_abnormal_muscle_weight1.39948763
74MP0002420_abnormal_adaptive_immunity1.39909398
75MP0001819_abnormal_immune_cell1.38438575
76MP0002452_abnormal_antigen_presenting1.33544939
77MP0002734_abnormal_mechanical_nocicepti1.32727418
78MP0005423_abnormal_somatic_nervous1.31651286
79MP0000678_abnormal_parathyroid_gland1.31283500
80* MP0006138_congestive_heart_failure1.30483548
81MP0002089_abnormal_postnatal_growth/wei1.29103266
82* MP0000747_muscle_weakness1.28659908
83MP0003045_fibrosis1.26693308
84* MP0005385_cardiovascular_system_phenoty1.26024904
85* MP0001544_abnormal_cardiovascular_syste1.26024904
86MP0003633_abnormal_nervous_system1.23494675
87MP0002736_abnormal_nociception_after1.22597394
88MP0002405_respiratory_system_inflammati1.20954047
89MP0004381_abnormal_hair_follicle1.20502138
90MP0004885_abnormal_endolymph1.20208970
91MP0006082_CNS_inflammation1.18820448
92MP0001440_abnormal_grooming_behavior1.18549436
93MP0004924_abnormal_behavior1.18446581
94MP0005386_behavior/neurological_phenoty1.18446581
95MP0002106_abnormal_muscle_physiology1.17901479
96MP0005167_abnormal_blood-brain_barrier1.16687450
97MP0010155_abnormal_intestine_physiology1.16389984
98MP0010630_abnormal_cardiac_muscle1.15934559
99MP0003879_abnormal_hair_cell1.15920229
100MP0003566_abnormal_cell_adhesion1.14950683
101MP0002067_abnormal_sensory_capabilities1.14055701
102MP0000003_abnormal_adipose_tissue1.12620925
103MP0004811_abnormal_neuron_physiology1.11256374
104MP0003878_abnormal_ear_physiology1.10611439
105MP0005377_hearing/vestibular/ear_phenot1.10611439
106MP0003122_maternal_imprinting1.10570495
107MP0009785_altered_susceptibility_to1.09287195
108MP0003075_altered_response_to1.09206213
109MP0005464_abnormal_platelet_physiology1.06724487
110MP0000716_abnormal_immune_system1.05896051
111MP0002733_abnormal_thermal_nociception1.04763444
112MP0000759_abnormal_skeletal_muscle1.04070087
113MP0001970_abnormal_pain_threshold1.04064898
114MP0005535_abnormal_body_temperature1.03144792
115MP0001545_abnormal_hematopoietic_system1.02935399
116MP0005397_hematopoietic_system_phenotyp1.02935399
117MP0003763_abnormal_thymus_physiology1.02658245
118MP0002398_abnormal_bone_marrow1.01711098
119MP0003866_abnormal_defecation1.01142087
120MP0003690_abnormal_glial_cell1.00496500
121MP0005390_skeleton_phenotype1.00459588
122MP0002933_joint_inflammation1.00379776
123MP0003172_abnormal_lysosome_physiology1.00085275
124MP0000230_abnormal_systemic_arterial0.99926325
125MP0002066_abnormal_motor_capabilities/c0.99612225
126MP0005369_muscle_phenotype0.99539592
127MP0003283_abnormal_digestive_organ0.99488677
128MP0005623_abnormal_meninges_morphology0.99137470
129MP0002557_abnormal_social/conspecific_i0.97969912
130MP0000858_altered_metastatic_potential0.96252460
131MP0003123_paternal_imprinting0.96245092
132MP0002148_abnormal_hypersensitivity_rea0.96159916
133MP0003453_abnormal_keratinocyte_physiol0.95847621
134MP0000604_amyloidosis0.95548829
135MP0000767_abnormal_smooth_muscle0.95182489
136MP0005670_abnormal_white_adipose0.92751113
137MP0003828_pulmonary_edema0.91650290
138MP0002234_abnormal_pharynx_morphology0.91162530
139MP0001873_stomach_inflammation0.91012946
140MP0005666_abnormal_adipose_tissue0.89757066
141MP0005375_adipose_tissue_phenotype0.89098587
142MP0009333_abnormal_splenocyte_physiolog0.88705879
143MP0005310_abnormal_salivary_gland0.86395728
144MP0005058_abnormal_lysosome_morphology0.85658374
145MP0008874_decreased_physiological_sensi0.85616315
146MP0003631_nervous_system_phenotype0.85510829
147MP0001502_abnormal_circadian_rhythm0.85503266
148MP0010329_abnormal_lipoprotein_level0.84742644
149MP0002078_abnormal_glucose_homeostasis0.84296949
150MP0000920_abnormal_myelination0.84139370
151MP0002735_abnormal_chemical_nociception0.82843682
152MP0001845_abnormal_inflammatory_respons0.82228340
153MP0000955_abnormal_spinal_cord0.81945246
154MP0002090_abnormal_vision0.81770611
155MP0000750_abnormal_muscle_regeneration0.81639014
156MP0001663_abnormal_digestive_system0.79689522
157MP0002429_abnormal_blood_cell0.78698571
158* MP0003634_abnormal_glial_cell0.78358225
159MP0010368_abnormal_lymphatic_system0.78352813
160MP0000703_abnormal_thymus_morphology0.75531754
161MP0001851_eye_inflammation0.74990126
162MP0000778_abnormal_nervous_system0.74915094
163MP0002069_abnormal_eating/drinking_beha0.74729132
164MP0005646_abnormal_pituitary_gland0.74349842
165MP0005332_abnormal_amino_acid0.74250396
166MP0002184_abnormal_innervation0.73662388
167MP0002882_abnormal_neuron_morphology0.73503838
168MP0002118_abnormal_lipid_homeostasis0.72661785
169MP0005166_decreased_susceptibility_to0.72628959
170MP0003221_abnormal_cardiomyocyte_apopto0.71278005
171MP0005257_abnormal_intraocular_pressure0.70828701
172MP0008469_abnormal_protein_level0.70693088
173MP0003183_abnormal_peptide_metabolism0.70610272
174MP0002722_abnormal_immune_system0.70086512
175MP0008438_abnormal_cutaneous_collagen0.69047023
176MP0009115_abnormal_fat_cell0.64790420

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)4.36902271
2Obstructive sleep apnea (HP:0002870)4.35311566
3Myokymia (HP:0002411)3.99624072
4Bundle branch block (HP:0011710)3.88997748
5Exercise-induced myalgia (HP:0003738)3.86058062
6Focal motor seizures (HP:0011153)3.58780541
7Eczematoid dermatitis (HP:0000976)3.55102318
8Visual hallucinations (HP:0002367)3.46820375
9Ventricular fibrillation (HP:0001663)3.45105433
10Atrial fibrillation (HP:0005110)3.44586583
11Primary atrial arrhythmia (HP:0001692)3.30378201
12Exercise-induced muscle cramps (HP:0003710)3.28049693
13Prolonged QT interval (HP:0001657)3.20639484
14Syncope (HP:0001279)3.18894123
15Calf muscle hypertrophy (HP:0008981)3.16156667
16Supraventricular tachycardia (HP:0004755)3.13397366
17Asymmetric septal hypertrophy (HP:0001670)3.12742542
18Ventricular tachycardia (HP:0004756)3.08515865
19Supraventricular arrhythmia (HP:0005115)3.08184467
20Pheochromocytoma (HP:0002666)3.05405666
21Hyperacusis (HP:0010780)3.02991760
22Focal seizures (HP:0007359)2.98000749
23Myoglobinuria (HP:0002913)2.93627213
24Ketoacidosis (HP:0001993)2.89714550
25Ventricular arrhythmia (HP:0004308)2.89252837
26Abnormal EKG (HP:0003115)2.81615720
27Myositis (HP:0100614)2.81559631
28Muscle hypertrophy of the lower extremities (HP:0008968)2.81242843
29Abnormality of the calf musculature (HP:0001430)2.80832639
30Orchitis (HP:0100796)2.78875331
31Heart block (HP:0012722)2.70426659
32Dysmetric saccades (HP:0000641)2.68158243
33Ankle clonus (HP:0011448)2.67061194
34Abnormality of macrophages (HP:0004311)2.64154844
35Epileptic encephalopathy (HP:0200134)2.58222320
36Neuroendocrine neoplasm (HP:0100634)2.56457533
37Impaired social interactions (HP:0000735)2.56314373
38Abnormal social behavior (HP:0012433)2.56314373
39Increased cerebral lipofuscin (HP:0011813)2.55372583
40Broad face (HP:0000283)2.54566471
41Cellulitis (HP:0100658)2.53847416
42Supranuclear gaze palsy (HP:0000605)2.52490005
43Right ventricular cardiomyopathy (HP:0011663)2.52336233
44Depression (HP:0000716)2.50100298
45Abnormal atrioventricular conduction (HP:0005150)2.49106052
46Atrioventricular block (HP:0001678)2.48733768
47Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.47082205
48Poor eye contact (HP:0000817)2.42372707
49Lipoatrophy (HP:0100578)2.41403624
50Palpitations (HP:0001962)2.40981377
51Abnormality of the fingertips (HP:0001211)2.40841222
52EMG: myopathic abnormalities (HP:0003458)2.36761491
53Muscle fiber splitting (HP:0003555)2.35445867
54Thin bony cortex (HP:0002753)2.34406054
55Hemiplegia (HP:0002301)2.33917237
56Increased neuronal autofluorescent lipopigment (HP:0002074)2.33519896
57Subaortic stenosis (HP:0001682)2.33455783
58Abnormality of the left ventricular outflow tract (HP:0011103)2.33455783
59Hemorrhage of the eye (HP:0011885)2.33189736
60Myotonia (HP:0002486)2.32934708
61Ketosis (HP:0001946)2.32076436
62Anxiety (HP:0000739)2.31831717
63Recurrent gram-negative bacterial infections (HP:0005420)2.31705108
64Postural instability (HP:0002172)2.31397630
65Gastrointestinal infarctions (HP:0005244)2.31311401
66Increased variability in muscle fiber diameter (HP:0003557)2.31242593
67Difficulty running (HP:0009046)2.31153986
68Gout (HP:0001997)2.30981755
69Action tremor (HP:0002345)2.30079159
70Peritonitis (HP:0002586)2.27878002
71Shallow orbits (HP:0000586)2.26123291
72Abnormality of the lower motor neuron (HP:0002366)2.25591471
73Dysostosis multiplex (HP:0000943)2.24836723
74Optic neuritis (HP:0100653)2.23771706
75Retrobulbar optic neuritis (HP:0100654)2.23771706
76Dysdiadochokinesis (HP:0002075)2.22932315
77Hyporeflexia of lower limbs (HP:0002600)2.22634722
78Increased IgE level (HP:0003212)2.21899730
79Recurrent abscess formation (HP:0002722)2.20077622
80Annular pancreas (HP:0001734)2.19412830
81Mediastinal lymphadenopathy (HP:0100721)2.17543998
82Protrusio acetabuli (HP:0003179)2.17159690
83Recurrent bacterial skin infections (HP:0005406)2.16917256
84Torticollis (HP:0000473)2.16756944
85Disproportionate tall stature (HP:0001519)2.16498421
86Gingivitis (HP:0000230)2.16399908
87Impaired vibration sensation in the lower limbs (HP:0002166)2.15072713
88Generalized tonic-clonic seizures (HP:0002069)2.14635751
89Atonic seizures (HP:0010819)2.14624422
90Segmental peripheral demyelination/remyelination (HP:0003481)2.11673243
91Abnormality of mucopolysaccharide metabolism (HP:0011020)2.07375567
92Abnormality of polysaccharide metabolism (HP:0011012)2.07375567
93Abnormality of glycosaminoglycan metabolism (HP:0004371)2.07375567
94Dilated cardiomyopathy (HP:0001644)2.06692957
95Bronchomalacia (HP:0002780)2.06534703
96Absence seizures (HP:0002121)2.04875652
97Chronic obstructive pulmonary disease (HP:0006510)2.03659151
98Obstructive lung disease (HP:0006536)2.03659151
99Urinary glycosaminoglycan excretion (HP:0003541)2.02519641
100Mucopolysacchariduria (HP:0008155)2.02519641
101Diplopia (HP:0000651)2.00927059
102Abnormality of binocular vision (HP:0011514)2.00927059
103Abnormal eating behavior (HP:0100738)2.00825804
104Emphysema (HP:0002097)2.00369414
105Hyperventilation (HP:0002883)1.97867748
106J-shaped sella turcica (HP:0002680)1.97373524
107Neuronal loss in central nervous system (HP:0002529)1.96568734
108Neurofibrillary tangles (HP:0002185)1.96189796
109Progressive cerebellar ataxia (HP:0002073)1.96053305
110Aneurysm (HP:0002617)1.95329232
111Genu recurvatum (HP:0002816)1.94490154
112Tinnitus (HP:0000360)1.94276896
113Centrally nucleated skeletal muscle fibers (HP:0003687)1.94242857
114Left ventricular hypertrophy (HP:0001712)1.93625083
115Meningitis (HP:0001287)1.93050465
116Dysmetria (HP:0001310)1.92855308
117Rapidly progressive (HP:0003678)1.92127013
118Cerebral inclusion bodies (HP:0100314)1.92051332
119Metaphyseal cupping (HP:0003021)1.91428023
120Focal dystonia (HP:0004373)1.90609966
121Hypercortisolism (HP:0001578)1.90547849
122Urinary bladder sphincter dysfunction (HP:0002839)1.90014247
123Broad metatarsal (HP:0001783)1.88879194
124Urinary urgency (HP:0000012)1.87719237
125Deep venous thrombosis (HP:0002625)1.87429018
126Mutism (HP:0002300)1.87262785
127Amyloidosis (HP:0011034)1.86823110
128Abnormality of the thoracic spine (HP:0100711)1.86760839
129Lymphangioma (HP:0100764)1.86281349
130Abnormality of skeletal muscle fiber size (HP:0012084)1.85788225
131Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.85490430
132Status epilepticus (HP:0002133)1.84969079
133Long palpebral fissure (HP:0000637)1.84940258
134Onion bulb formation (HP:0003383)1.84710323
135Spontaneous hematomas (HP:0007420)1.83746928
136Truncal ataxia (HP:0002078)1.82241137
137Athetosis (HP:0002305)1.81609390
138Stridor (HP:0010307)1.80398074
139Mitral regurgitation (HP:0001653)1.79460195
140Gastrointestinal stroma tumor (HP:0100723)1.79362943
141Resting tremor (HP:0002322)1.78121338
142Craniofacial dystonia (HP:0012179)1.77992503
143Polygenic inheritance (HP:0010982)1.77896469
144Pointed chin (HP:0000307)1.77163886
145Hamartoma of the eye (HP:0010568)1.77072499
146Elevated erythrocyte sedimentation rate (HP:0003565)1.76705571
147Dialeptic seizures (HP:0011146)1.76286984
148Neoplasm of the peripheral nervous system (HP:0100007)1.75623369
149Central scotoma (HP:0000603)1.75131696
150Distal upper limb amyotrophy (HP:0007149)1.73635243
151Upper limb amyotrophy (HP:0009129)1.73635243
152Cervical subluxation (HP:0003308)1.73370417
153Lower limb amyotrophy (HP:0007210)1.72734663
154Febrile seizures (HP:0002373)1.72505588
155Intention tremor (HP:0002080)1.72183346
156Cerebral aneurysm (HP:0004944)1.72120881
157Thoracic kyphosis (HP:0002942)1.71894760
158Lower limb muscle weakness (HP:0007340)1.71612916
159Hypochromic anemia (HP:0001931)1.71435975
160Systemic lupus erythematosus (HP:0002725)1.71374597
161Cerebral hemorrhage (HP:0001342)1.71341880
162Distal lower limb amyotrophy (HP:0008944)1.70821680
163Recurrent fungal infections (HP:0002841)1.70754005
164Vasculitis (HP:0002633)1.69748114
165Turricephaly (HP:0000262)1.68818179
166Loss of speech (HP:0002371)1.68538989
167Ulnar bowing (HP:0003031)1.68075310
168Chest pain (HP:0100749)1.67943467
169Abnormality of the periventricular white matter (HP:0002518)1.67760829
170Increased connective tissue (HP:0009025)1.67336087
171Abnormality of glycolipid metabolism (HP:0010969)1.67167332
172Abnormality of liposaccharide metabolism (HP:0010968)1.67167332
173Abnormality of glycosphingolipid metabolism (HP:0004343)1.67167332
174Easy fatigability (HP:0003388)1.66347499
175Peripheral hypomyelination (HP:0007182)1.65230089
176Neoplasm of the adrenal gland (HP:0100631)1.64530964
177Prolonged bleeding time (HP:0003010)1.64019798
178Difficulty climbing stairs (HP:0003551)1.63832368
179Interstitial pulmonary disease (HP:0006530)1.63537566
180Flat acetabular roof (HP:0003180)1.63189398
181Slow saccadic eye movements (HP:0000514)1.60373420
182Abnormality of the peritoneum (HP:0002585)1.60184586
183Dilatation of the ascending aorta (HP:0005111)1.59358050
184Restrictive lung disease (HP:0002091)1.59099581
185Gastrointestinal inflammation (HP:0004386)1.58721379
186Renovascular hypertension (HP:0100817)1.57869991
187Mitral valve prolapse (HP:0001634)1.57368069
188Persistence of primary teeth (HP:0006335)1.57029216

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K92.96495985
2EPHA42.96275404
3PRKD32.82339919
4TRIB32.79722505
5NTRK32.51961966
6DAPK22.32946389
7LMTK22.30622406
8ICK2.22853234
9SMG12.16639506
10CDK122.11470988
11MAP3K42.10990958
12MAP4K12.10910279
13PKN22.04881988
14PHKG22.03046019
15PHKG12.03046019
16PAK61.87530498
17KSR21.87258076
18TTN1.84277760
19CAMKK11.84220241
20MINK11.82914446
21EEF2K1.82697391
22MYLK1.80671753
23FGFR41.74890015
24MARK11.68690212
25MAP2K31.66431559
26TNK21.62367536
27MAP2K41.58130091
28MAP3K111.48761753
29NTRK11.48407728
30EPHB11.47876711
31PDK31.46355633
32PDK41.46355633
33MAP3K121.45890047
34RIPK11.42549655
35DMPK1.41286361
36TAOK11.39739765
37BCKDK1.39721452
38STK381.33677309
39PINK11.33194094
40IRAK41.30499158
41PRKCH1.30227493
42NEK11.28469449
43BLK1.24146527
44FES1.20825716
45PAK31.17380732
46CDC42BPA1.15634137
47TIE11.15156969
48ZAP701.12777781
49DAPK11.12577449
50KSR11.12359868
51CDK51.12213906
52TYK21.11534459
53MAP2K71.10240109
54IRAK31.07569596
55CAMK1D1.05852538
56MAP3K131.03548232
57NTRK21.03324128
58PDGFRA1.02780003
59ERN11.00326890
60ARAF1.00086063
61CSK0.99076861
62MAP3K30.95014700
63HIPK20.94281918
64TAOK20.94056660
65TBK10.93847536
66GRK60.93658385
67MTOR0.92192044
68CAMK10.91828528
69MAP3K70.91534769
70SGK30.91213591
71RET0.91075156
72PTK2B0.90969667
73RIPK40.88663383
74SGK2230.87869649
75SGK4940.87869649
76CAMK40.87830857
77PDPK10.86700563
78SIK30.86014330
79CAMKK20.85845922
80RPS6KL10.85593699
81RPS6KC10.85593699
82PDK10.85444438
83CDK190.85133323
84OBSCN0.84221183
85GRK50.82347236
86LATS20.80744757
87DAPK30.80599716
88PRPF4B0.79350894
89TYRO30.79296764
90PRKD10.78015682
91BTK0.77679063
92CAMK2A0.76893425
93UHMK10.76758572
94PDK20.75091924
95CAMK2D0.74845785
96DYRK1B0.74578350
97HCK0.73940442
98PRKCG0.73798317
99MAP3K140.73716218
100RPS6KA60.73552864
101STK110.72616437
102MAP3K20.71942286
103MAP3K10.69369517
104WNK40.69157181
105PTK60.65990224
106SIK20.64276772
107WNK10.64124992
108MAPK120.63892719
109FGFR30.63775997
110SGK20.63571633
111JAK10.62992365
112SIK10.62311062
113CHUK0.61577178
114JAK30.61395899
115KIT0.60449985
116ROCK10.59404596
117RPS6KA20.59139882
118ALK0.58571543
119MAP3K60.58432560
120CSF1R0.58305966
121MARK20.58244290
122SYK0.57726794
123PRKCZ0.56107442
124MAP3K100.53662812
125MAPK110.53656180
126MAPK70.52945610
127MAP2K10.52695914
128IKBKE0.52256083
129MATK0.52144696
130MAP2K20.52057543
131FGR0.51388667
132PRKAA10.51171220
133SGK10.51161659
134PTK20.50791494
135FER0.50140581
136OXSR10.50106304
137JAK20.49826520
138DDR20.49317625
139CAMK1G0.48946228
140ROCK20.48607020
141PRKD20.48446083
142PRKCE0.48140139
143MAPK130.47364081
144PDGFRB0.46921686
145WNK30.46195486
146IRAK20.45997525
147FYN0.45547064
148RPS6KA30.44986489
149CAMK2G0.44876380
150CDK150.44449993
151CDK180.43834114
152BMX0.43557688

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.77993536
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.48613011
3Synaptic vesicle cycle_Homo sapiens_hsa047212.35921448
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.30577203
5GABAergic synapse_Homo sapiens_hsa047271.98014371
6Circadian entrainment_Homo sapiens_hsa047131.97761053
7Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.97551295
8Nitrogen metabolism_Homo sapiens_hsa009101.90437489
9Nicotine addiction_Homo sapiens_hsa050331.86375566
10B cell receptor signaling pathway_Homo sapiens_hsa046621.80174300
11Notch signaling pathway_Homo sapiens_hsa043301.78879953
12Osteoclast differentiation_Homo sapiens_hsa043801.77639591
13Insulin secretion_Homo sapiens_hsa049111.74655895
14Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.74518537
15Acute myeloid leukemia_Homo sapiens_hsa052211.72651425
16Olfactory transduction_Homo sapiens_hsa047401.72111968
17Long-term potentiation_Homo sapiens_hsa047201.71899780
18Dilated cardiomyopathy_Homo sapiens_hsa054141.70390100
19Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.67132503
20Morphine addiction_Homo sapiens_hsa050321.66081041
21Cardiac muscle contraction_Homo sapiens_hsa042601.64387250
22Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.63726509
23Other glycan degradation_Homo sapiens_hsa005111.63161230
24Glutamatergic synapse_Homo sapiens_hsa047241.60570639
25Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.56615886
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.53721759
27Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.52244650
28Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.51931871
29Amphetamine addiction_Homo sapiens_hsa050311.51728086
30Gastric acid secretion_Homo sapiens_hsa049711.49102741
31Leishmaniasis_Homo sapiens_hsa051401.45528537
32Salivary secretion_Homo sapiens_hsa049701.45150851
33Chronic myeloid leukemia_Homo sapiens_hsa052201.40490221
34Dopaminergic synapse_Homo sapiens_hsa047281.38389992
35Non-small cell lung cancer_Homo sapiens_hsa052231.32594833
36Cholinergic synapse_Homo sapiens_hsa047251.31551401
37Renin secretion_Homo sapiens_hsa049241.31094914
38Toll-like receptor signaling pathway_Homo sapiens_hsa046201.28875871
39Type II diabetes mellitus_Homo sapiens_hsa049301.28849042
40Staphylococcus aureus infection_Homo sapiens_hsa051501.26325845
41Oxytocin signaling pathway_Homo sapiens_hsa049211.25786467
42Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.25260720
43Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.25126232
44Butanoate metabolism_Homo sapiens_hsa006501.23905632
45Propanoate metabolism_Homo sapiens_hsa006401.22450374
46Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.21379077
47Arginine biosynthesis_Homo sapiens_hsa002201.20379544
48Tuberculosis_Homo sapiens_hsa051521.20337101
49Fatty acid degradation_Homo sapiens_hsa000711.18651230
50Calcium signaling pathway_Homo sapiens_hsa040201.14935659
51Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.13355616
52Glycosaminoglycan degradation_Homo sapiens_hsa005311.13249953
53T cell receptor signaling pathway_Homo sapiens_hsa046601.12194107
54Endometrial cancer_Homo sapiens_hsa052131.11740083
55Cocaine addiction_Homo sapiens_hsa050301.09781076
56Chemokine signaling pathway_Homo sapiens_hsa040621.07842903
57Fatty acid metabolism_Homo sapiens_hsa012121.07011961
58TNF signaling pathway_Homo sapiens_hsa046681.06863563
59Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.05689584
60AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.05388441
61cGMP-PKG signaling pathway_Homo sapiens_hsa040221.04850691
62Carbon metabolism_Homo sapiens_hsa012001.04674495
63Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.04607200
64Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.01979984
65cAMP signaling pathway_Homo sapiens_hsa040241.01612656
66GnRH signaling pathway_Homo sapiens_hsa049121.01606582
67Prolactin signaling pathway_Homo sapiens_hsa049171.00422570
68Toxoplasmosis_Homo sapiens_hsa051450.99197019
69Prion diseases_Homo sapiens_hsa050200.99078556
70Collecting duct acid secretion_Homo sapiens_hsa049660.97123918
71Bile secretion_Homo sapiens_hsa049760.94908887
72Pancreatic cancer_Homo sapiens_hsa052120.94545135
73Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.93983119
74Gap junction_Homo sapiens_hsa045400.93653156
75Leukocyte transendothelial migration_Homo sapiens_hsa046700.93595855
76Malaria_Homo sapiens_hsa051440.93541193
77Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.93151470
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.92455827
79Hepatitis C_Homo sapiens_hsa051600.91991038
80Taste transduction_Homo sapiens_hsa047420.91857257
81Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.91445447
82Glucagon signaling pathway_Homo sapiens_hsa049220.90273710
83Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.89663808
84Bladder cancer_Homo sapiens_hsa052190.88844737
85Influenza A_Homo sapiens_hsa051640.88711245
86Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.88709545
87Long-term depression_Homo sapiens_hsa047300.87055503
88Estrogen signaling pathway_Homo sapiens_hsa049150.86870442
89Amoebiasis_Homo sapiens_hsa051460.86738342
90Hepatitis B_Homo sapiens_hsa051610.84018859
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.83844021
92Allograft rejection_Homo sapiens_hsa053300.83226640
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.81712696
94NF-kappa B signaling pathway_Homo sapiens_hsa040640.80518967
95Pyruvate metabolism_Homo sapiens_hsa006200.79464604
96Platelet activation_Homo sapiens_hsa046110.78676495
97Carbohydrate digestion and absorption_Homo sapiens_hsa049730.78353214
98Vibrio cholerae infection_Homo sapiens_hsa051100.78334489
99Rap1 signaling pathway_Homo sapiens_hsa040150.77967952
100Glioma_Homo sapiens_hsa052140.76832027
101Phosphatidylinositol signaling system_Homo sapiens_hsa040700.76755820
102Graft-versus-host disease_Homo sapiens_hsa053320.74430849
103PPAR signaling pathway_Homo sapiens_hsa033200.73454242
104Serotonergic synapse_Homo sapiens_hsa047260.72393027
105Viral myocarditis_Homo sapiens_hsa054160.71971533
106Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.71902558
107Thyroid hormone synthesis_Homo sapiens_hsa049180.71311377
108Insulin signaling pathway_Homo sapiens_hsa049100.70914313
109FoxO signaling pathway_Homo sapiens_hsa040680.70367559
110Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.69849502
111Insulin resistance_Homo sapiens_hsa049310.69223844
112Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.68681172
113Autoimmune thyroid disease_Homo sapiens_hsa053200.67681702
114Jak-STAT signaling pathway_Homo sapiens_hsa046300.67624191
115Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67400430
116Measles_Homo sapiens_hsa051620.67254546
117Pancreatic secretion_Homo sapiens_hsa049720.65339493
118Biosynthesis of amino acids_Homo sapiens_hsa012300.65203316
119Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.65035282
120Colorectal cancer_Homo sapiens_hsa052100.64353905
121Prostate cancer_Homo sapiens_hsa052150.64306059
122Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.64222426
123Apoptosis_Homo sapiens_hsa042100.64144321
124Pertussis_Homo sapiens_hsa051330.63645728
125African trypanosomiasis_Homo sapiens_hsa051430.63506262
126Phospholipase D signaling pathway_Homo sapiens_hsa040720.61702984
127Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61600775
128Phagosome_Homo sapiens_hsa041450.61075993
129Salmonella infection_Homo sapiens_hsa051320.60629957
130Adipocytokine signaling pathway_Homo sapiens_hsa049200.60394675
131HIF-1 signaling pathway_Homo sapiens_hsa040660.58308447
132Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57848452
133RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.57059325
134Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56208964
135Melanogenesis_Homo sapiens_hsa049160.54993164
136Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52479222
137Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51934293
138Fructose and mannose metabolism_Homo sapiens_hsa000510.51391144
139ErbB signaling pathway_Homo sapiens_hsa040120.51197599
140Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.50482839
141Neurotrophin signaling pathway_Homo sapiens_hsa047220.50477364
142Dorso-ventral axis formation_Homo sapiens_hsa043200.49872801
143VEGF signaling pathway_Homo sapiens_hsa043700.48762976
144Tryptophan metabolism_Homo sapiens_hsa003800.48644642
145mTOR signaling pathway_Homo sapiens_hsa041500.47303470
146Endocytosis_Homo sapiens_hsa041440.44064374
147AMPK signaling pathway_Homo sapiens_hsa041520.43769517
148Alzheimers disease_Homo sapiens_hsa050100.42925877
149Central carbon metabolism in cancer_Homo sapiens_hsa052300.41582237
150Axon guidance_Homo sapiens_hsa043600.41271260
151Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.39925775
152MAPK signaling pathway_Homo sapiens_hsa040100.39329774
153Inositol phosphate metabolism_Homo sapiens_hsa005620.38982770
154Lysosome_Homo sapiens_hsa041420.38586263
155Renal cell carcinoma_Homo sapiens_hsa052110.38172660
156Starch and sucrose metabolism_Homo sapiens_hsa005000.38143048
157Choline metabolism in cancer_Homo sapiens_hsa052310.38027366
158Primary bile acid biosynthesis_Homo sapiens_hsa001200.37582109
159Focal adhesion_Homo sapiens_hsa045100.37393717

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