MGMT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Alkylating agents are potent carcinogens that can result in cell death, mutation and cancer. The protein encoded by this gene is a DNA repair protein that is involved in cellular defense against mutagenesis and toxicity from alkylating agents. The protein catalyzes transfer of methyl groups from O(6)-alkylguanine and other methylated moieties of the DNA to its own molecule, which repairs the toxic lesions. Methylation of the genes promoter has been associated with several cancer types, including colorectal cancer, lung cancer, lymphoma and glioblastoma. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)6.70489545
2ribosomal small subunit biogenesis (GO:0042274)6.56749117
3translational termination (GO:0006415)6.34447690
4ribosomal small subunit assembly (GO:0000028)6.02912129
5SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.76908267
6cotranslational protein targeting to membrane (GO:0006613)5.70741976
7protein targeting to ER (GO:0045047)5.68246202
8protein localization to endoplasmic reticulum (GO:0070972)5.40140963
9establishment of protein localization to endoplasmic reticulum (GO:0072599)5.35663226
10omega-hydroxylase P450 pathway (GO:0097267)5.34206206
11translational elongation (GO:0006414)5.04530624
12nucleotide salvage (GO:0043173)4.91176328
13viral life cycle (GO:0019058)4.86923285
14cellular protein complex disassembly (GO:0043624)4.63087870
15ribosomal large subunit biogenesis (GO:0042273)4.57276179
16proteasome assembly (GO:0043248)4.53591095
17nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.34427857
18purine nucleotide salvage (GO:0032261)4.34199570
19maturation of SSU-rRNA (GO:0030490)4.22918950
20DNA deamination (GO:0045006)4.18378761
21glyoxylate metabolic process (GO:0046487)4.17822240
22tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.13166320
23RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.13166320
24translational initiation (GO:0006413)4.07573626
25erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.85979308
26L-phenylalanine catabolic process (GO:0006559)3.85979308
27protein complex disassembly (GO:0043241)3.81523772
28short-term memory (GO:0007614)3.77544059
29nucleoside salvage (GO:0043174)3.76015479
30amino sugar catabolic process (GO:0046348)3.71813461
31serine family amino acid catabolic process (GO:0009071)3.65590113
32pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.62562362
33protein targeting to membrane (GO:0006612)3.62484709
34termination of RNA polymerase III transcription (GO:0006386)3.59494541
35transcription elongation from RNA polymerase III promoter (GO:0006385)3.59494541
36macromolecular complex disassembly (GO:0032984)3.58392078
37respiratory chain complex IV assembly (GO:0008535)3.58136338
38positive regulation of cellular amine metabolic process (GO:0033240)3.56617115
39endothelium development (GO:0003158)3.56494767
40mesonephros development (GO:0001823)3.55483741
41translation (GO:0006412)3.49035972
42mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.41627230
43deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.39573831
44protein heterotetramerization (GO:0051290)3.36071471
45negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.30688497
46GTP biosynthetic process (GO:0006183)3.28444288
47pentose metabolic process (GO:0019321)3.27699020
48pyrimidine nucleoside salvage (GO:0043097)3.22581384
49pyrimidine-containing compound salvage (GO:0008655)3.22581384
50mitochondrial respiratory chain complex assembly (GO:0033108)3.21634039
51xenobiotic catabolic process (GO:0042178)3.20358785
52energy coupled proton transport, down electrochemical gradient (GO:0015985)3.20328061
53ATP synthesis coupled proton transport (GO:0015986)3.20328061
54pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.16364808
55drug catabolic process (GO:0042737)3.13753512
56deoxyribonucleotide catabolic process (GO:0009264)3.12270609
57pattern specification involved in kidney development (GO:0061004)3.09870585
58exogenous drug catabolic process (GO:0042738)3.08993587
59regulation of plasminogen activation (GO:0010755)3.06037646
60respiratory electron transport chain (GO:0022904)3.05803464
61lymphoid progenitor cell differentiation (GO:0002320)3.04256740
62electron transport chain (GO:0022900)3.03370198
63deoxyribose phosphate catabolic process (GO:0046386)3.02068090
64signal peptide processing (GO:0006465)3.01639555
65epoxygenase P450 pathway (GO:0019373)3.01433139
66cellular metabolic compound salvage (GO:0043094)2.99902801
67nuclear-transcribed mRNA catabolic process (GO:0000956)2.97635057
68regulation of cholesterol esterification (GO:0010872)2.97133665
69sulfur amino acid catabolic process (GO:0000098)2.96940373
70ribonucleoprotein complex biogenesis (GO:0022613)2.94851654
71polyketide metabolic process (GO:0030638)2.94822976
72doxorubicin metabolic process (GO:0044598)2.94822976
73daunorubicin metabolic process (GO:0044597)2.94822976
74positive regulation of prostaglandin secretion (GO:0032308)2.93262728
75aminoglycoside antibiotic metabolic process (GO:0030647)2.93013587
76phenylpropanoid metabolic process (GO:0009698)2.92904428
77regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.92483662
78N-acetylneuraminate metabolic process (GO:0006054)2.91381743
79cytochrome complex assembly (GO:0017004)2.91050125
80aromatic amino acid family catabolic process (GO:0009074)2.88448180
81mRNA catabolic process (GO:0006402)2.87200876
82L-serine metabolic process (GO:0006563)2.83642674
83blood coagulation, intrinsic pathway (GO:0007597)2.83583857
84glucosamine-containing compound catabolic process (GO:1901072)2.81339681
85androgen biosynthetic process (GO:0006702)2.80718544
86complement activation, alternative pathway (GO:0006957)2.77808381
87aldehyde catabolic process (GO:0046185)2.77392318
88purine deoxyribonucleotide catabolic process (GO:0009155)2.76229955
89regulation of apoptotic process involved in morphogenesis (GO:1902337)2.75231256
90facial nerve structural organization (GO:0021612)2.74069421
91pyrimidine nucleotide catabolic process (GO:0006244)2.73124833
92pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.71056446
93galactose catabolic process (GO:0019388)2.70161178
94UTP biosynthetic process (GO:0006228)2.68486949
95regulation of interleukin-8 secretion (GO:2000482)2.65694134
96establishment of protein localization to mitochondrial membrane (GO:0090151)2.65205008
97positive regulation of icosanoid secretion (GO:0032305)2.64428757
98pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.64014572
99postsynaptic membrane organization (GO:0001941)2.63576352
100positive regulation of chemokine secretion (GO:0090197)2.63274171
101ethanol oxidation (GO:0006069)2.62611312
102axon ensheathment in central nervous system (GO:0032291)2.60913370
103central nervous system myelination (GO:0022010)2.60913370
104glycine metabolic process (GO:0006544)2.60604746
105deoxyribose phosphate biosynthetic process (GO:0046385)2.59896967
1062-deoxyribonucleotide biosynthetic process (GO:0009265)2.59896967
107bile acid biosynthetic process (GO:0006699)2.59850531
108purine-containing compound salvage (GO:0043101)2.59819144
109pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.58830069
110deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.58318422
111branched-chain amino acid catabolic process (GO:0009083)2.57696318
112drug metabolic process (GO:0017144)2.57691208
113GPI anchor biosynthetic process (GO:0006506)2.57466550
114cellular component biogenesis (GO:0044085)2.56337342
115pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.56008875
116amino acid salvage (GO:0043102)2.55821753
117L-methionine salvage (GO:0071267)2.55821753
118L-methionine biosynthetic process (GO:0071265)2.55821753
119regulation of triglyceride catabolic process (GO:0010896)2.55714985
120triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.55576580
121RNA catabolic process (GO:0006401)2.54785651
122regulation of development, heterochronic (GO:0040034)2.54422573
1232-deoxyribonucleotide metabolic process (GO:0009394)2.53840617
124base-excision repair, AP site formation (GO:0006285)2.52993452
125regulation of metalloenzyme activity (GO:0048552)2.52315477
126platelet dense granule organization (GO:0060155)2.51661675
127phospholipid efflux (GO:0033700)2.49768958
128serine family amino acid metabolic process (GO:0009069)2.49068568
129negative regulation of transcription by competitive promoter binding (GO:0010944)2.48985930
130mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.48870450
131deoxyribose phosphate metabolic process (GO:0019692)2.48842037
132mature B cell differentiation involved in immune response (GO:0002313)2.45561210
133regulation of timing of cell differentiation (GO:0048505)2.44666007
134DNA damage response, detection of DNA damage (GO:0042769)2.44110374
135regulation of pigment cell differentiation (GO:0050932)2.43500816
136glutathione derivative metabolic process (GO:1901685)2.43432296
137presynaptic membrane assembly (GO:0097105)2.43294544
138mesenchymal cell differentiation involved in kidney development (GO:0072161)2.41017088
139mesenchymal cell differentiation involved in renal system development (GO:2001012)2.41017088
140CTP metabolic process (GO:0046036)2.38922599
141CTP biosynthetic process (GO:0006241)2.38922599
142mature B cell differentiation (GO:0002335)2.37733714
143GMP metabolic process (GO:0046037)2.36469775
144regulation of mesenchymal cell apoptotic process (GO:2001053)2.35367210
145positive regulation of protein kinase C signaling (GO:0090037)2.35243660
146mesenchymal to epithelial transition (GO:0060231)2.35172493
147protein complex biogenesis (GO:0070271)2.34694845
148establishment of protein localization to membrane (GO:0090150)2.33432890
149response to increased oxygen levels (GO:0036296)2.32300052
150response to hyperoxia (GO:0055093)2.32300052
151mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.32109546
152mitochondrial respiratory chain complex I assembly (GO:0032981)2.32109546
153NADH dehydrogenase complex assembly (GO:0010257)2.32109546
154tRNA modification (GO:0006400)2.29720441
155rRNA processing (GO:0006364)2.29116440
156sphingoid metabolic process (GO:0046519)2.28824614
157response to interferon-beta (GO:0035456)2.28465835
158negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.27834667
159tRNA methylation (GO:0030488)2.27805982
160nephron epithelium development (GO:0072009)2.27739821
161UTP metabolic process (GO:0046051)2.26973212
162L-phenylalanine metabolic process (GO:0006558)2.26444850
163erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.26444850
164mannosylation (GO:0097502)2.26270579
165protein targeting (GO:0006605)2.25623607
166centriole assembly (GO:0098534)2.25143644
167exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.24277354
168limb bud formation (GO:0060174)2.24217059
169negative regulation of leukocyte chemotaxis (GO:0002689)2.22664254
170radial glial cell differentiation (GO:0060019)2.22194518

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat6.86201371
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.25234642
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.68024551
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.55350421
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.54804096
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.45523040
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.31739254
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.04279111
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.99288240
10EGR1_23403033_ChIP-Seq_LIVER_Mouse2.96888069
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.85989391
12KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.58775935
13KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.58775935
14KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.58775935
15TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.40803588
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.32544875
17BP1_19119308_ChIP-ChIP_Hs578T_Human2.27893257
18NOTCH1_21737748_ChIP-Seq_TLL_Human2.27292388
19IRF1_19129219_ChIP-ChIP_H3396_Human2.23459048
20EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.21367022
21GABP_17652178_ChIP-ChIP_JURKAT_Human2.20848932
22EST1_17652178_ChIP-ChIP_JURKAT_Human2.16678698
23JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.11833646
24PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.11491479
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.06124338
26RXR_22158963_ChIP-Seq_LIVER_Mouse1.99974978
27CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.95905619
28PPARA_22158963_ChIP-Seq_LIVER_Mouse1.92853151
29MYC_18358816_ChIP-ChIP_MESCs_Mouse1.89536567
30PCGF2_27294783_Chip-Seq_ESCs_Mouse1.87849045
31* CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.87477846
32SRF_21415370_ChIP-Seq_HL-1_Mouse1.77250913
33FLI1_27457419_Chip-Seq_LIVER_Mouse1.77079865
34CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.73309083
35FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.70803912
36ETS1_20019798_ChIP-Seq_JURKAT_Human1.70087713
37TRIM28_21343339_ChIP-Seq_HEK293_Human1.66464214
38BCL6_27268052_Chip-Seq_Bcells_Human1.62449352
39IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.55630549
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55567389
41SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.55068460
42* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.53704227
43SRY_22984422_ChIP-ChIP_TESTIS_Rat1.53479646
44BMI1_23680149_ChIP-Seq_NPCS_Mouse1.49149746
45KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.48297860
46POU5F1_16153702_ChIP-ChIP_HESCs_Human1.48019788
47MYC_19030024_ChIP-ChIP_MESCs_Mouse1.47905487
48CTCF_18555785_ChIP-Seq_MESCs_Mouse1.47362291
49FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.46367253
50TTF2_22483619_ChIP-Seq_HELA_Human1.44820396
51LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.44215855
52TET1_21451524_ChIP-Seq_MESCs_Mouse1.44053341
53HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.43132342
54CTCF_26484167_Chip-Seq_Bcells_Mouse1.42992439
55E2F1_18555785_ChIP-Seq_MESCs_Mouse1.42307014
56CREB1_15753290_ChIP-ChIP_HEK293T_Human1.40586238
57GABP_19822575_ChIP-Seq_HepG2_Human1.40484130
58ELF1_20517297_ChIP-Seq_JURKAT_Human1.40366724
59EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.38239241
60ELK1_22589737_ChIP-Seq_MCF10A_Human1.38227360
61CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.38008645
62VDR_21846776_ChIP-Seq_THP-1_Human1.37716755
63E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.37620647
64YY1_22570637_ChIP-Seq_MALME-3M_Human1.36483919
65POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.35965057
66NFE2_27457419_Chip-Seq_LIVER_Mouse1.35723985
67RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.35651959
68BCOR_27268052_Chip-Seq_Bcells_Human1.34275207
69VDR_23849224_ChIP-Seq_CD4+_Human1.33755869
70ELK1_19687146_ChIP-ChIP_HELA_Human1.33393302
71LXR_22292898_ChIP-Seq_THP-1_Human1.31920264
72PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.31610539
73MYC_18940864_ChIP-ChIP_HL60_Human1.31474643
74P68_20966046_ChIP-Seq_HELA_Human1.30444869
75SUZ12_27294783_Chip-Seq_NPCs_Mouse1.30085051
76DCP1A_22483619_ChIP-Seq_HELA_Human1.29231274
77RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.29221879
78NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.27377269
79CTCF_20526341_ChIP-Seq_ESCs_Human1.27066670
80GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.25833411
81BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.25047225
82THAP11_20581084_ChIP-Seq_MESCs_Mouse1.23666534
83IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.23167567
84E2F1_20622854_ChIP-Seq_HELA_Human1.21247917
85ESR1_15608294_ChIP-ChIP_MCF-7_Human1.20978321
86IRF8_21731497_ChIP-ChIP_J774_Mouse1.19905829
87FOXP3_21729870_ChIP-Seq_TREG_Human1.19236930
88TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18628831
89* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.16485962
90IRF8_22096565_ChIP-ChIP_GC-B_Human1.16306681
91FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.16144918
92SA1_27219007_Chip-Seq_Bcells_Human1.15618106
93ERG_20887958_ChIP-Seq_HPC-7_Mouse1.15207701
94BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.15095856
95CBX2_27304074_Chip-Seq_ESCs_Mouse1.14400460
96* P300_27268052_Chip-Seq_Bcells_Human1.13306563
97HOXB4_20404135_ChIP-ChIP_EML_Mouse1.12925785
98SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.12810281
99SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.12234918
100YY1_21170310_ChIP-Seq_MESCs_Mouse1.12060336
101ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.11544779
102CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.11194052
103RNF2_27304074_Chip-Seq_NSC_Mouse1.09898870
104TAF15_26573619_Chip-Seq_HEK293_Human1.09293163
105MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.08931047
106RAD21_21589869_ChIP-Seq_MESCs_Mouse1.08186259
107MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.08091775
108PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07861331
109SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.07834789
110LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.06797837
111ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.06595727
112TAF2_19829295_ChIP-Seq_ESCs_Human1.06298170
113PU.1_20513432_ChIP-Seq_Bcells_Mouse1.06054978
114E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.06008908
115SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05942962
116TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.05153445
117PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.05109513
118SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04653804
119SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03994454
120EZH2_27294783_Chip-Seq_NPCs_Mouse1.03693603
121TCF3_18692474_ChIP-Seq_MEFs_Mouse1.03662630
122STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.03355389
123RUNX1_27457419_Chip-Seq_LIVER_Mouse1.03249306
124XRN2_22483619_ChIP-Seq_HELA_Human1.03123159
125RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.02707754
126CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.01949013
127MAF_26560356_Chip-Seq_TH2_Human1.00313475
128SPI1_23547873_ChIP-Seq_NB4_Human0.99814441
129PHF8_20622854_ChIP-Seq_HELA_Human0.98974853
130EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.98907384
131* LXR_22158963_ChIP-Seq_LIVER_Mouse0.98518380
132EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97997023
133* TP53_20018659_ChIP-ChIP_R1E_Mouse0.97708984
134CDX2_20551321_ChIP-Seq_CACO-2_Human0.97664819
135PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.97644801
136UTX_26944678_Chip-Seq_JUKART_Human0.97594724
137* NANOG_20526341_ChIP-Seq_ESCs_Human0.97482434
138LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.96829882
139ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.96087276
140ZFP57_27257070_Chip-Seq_ESCs_Mouse0.95774125
141KAP1_22055183_ChIP-Seq_ESCs_Mouse0.95762865
142IGF1R_20145208_ChIP-Seq_DFB_Human0.93939081
143FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.93859339
144P300_18555785_Chip-Seq_ESCs_Mouse0.93667397
145SCL_19346495_ChIP-Seq_HPC-7_Human0.93414954
146NMYC_18555785_Chip-Seq_ESCs_Mouse0.92441757
147EED_16625203_ChIP-ChIP_MESCs_Mouse0.91904525
148STAT1_20625510_ChIP-Seq_HELA_Human0.91290422
149WT1_19549856_ChIP-ChIP_CCG9911_Human0.89428496
150CRX_20693478_ChIP-Seq_RETINA_Mouse0.89214559
151SOX2_18692474_ChIP-Seq_MEFs_Mouse0.88750649
152SMC3_22415368_ChIP-Seq_MEFs_Mouse0.88054676
153STAT4_19710469_ChIP-ChIP_TH1__Mouse0.86957950
154EZH2_22144423_ChIP-Seq_EOC_Human0.85937042
155FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.85452789

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation7.80637826
2MP0003136_yellow_coat_color5.25056954
3MP0004381_abnormal_hair_follicle3.75107365
4MP0001188_hyperpigmentation3.54940628
5MP0003724_increased_susceptibility_to3.49366883
6MP0005409_darkened_coat_color3.23836102
7MP0006292_abnormal_olfactory_placode2.85870645
8MP0003941_abnormal_skin_development2.83370537
9MP0002138_abnormal_hepatobiliary_system2.82620501
10MP0002139_abnormal_hepatobiliary_system2.55157163
11MP0005365_abnormal_bile_salt2.54462150
12MP0000566_synostosis2.33799787
13MP0005174_abnormal_tail_pigmentation2.29527558
14MP0009840_abnormal_foam_cell2.23697599
15MP0005332_abnormal_amino_acid2.05936369
16MP0003878_abnormal_ear_physiology2.04225354
17MP0005377_hearing/vestibular/ear_phenot2.04225354
18MP0005075_abnormal_melanosome_morpholog1.94243994
19MP0000372_irregular_coat_pigmentation1.93019944
20MP0003252_abnormal_bile_duct1.91530481
21MP0003806_abnormal_nucleotide_metabolis1.85812168
22MP0003011_delayed_dark_adaptation1.85352381
23MP0002249_abnormal_larynx_morphology1.82151705
24MP0005058_abnormal_lysosome_morphology1.79597496
25MP0006036_abnormal_mitochondrial_physio1.78789275
26MP0002102_abnormal_ear_morphology1.76240521
27MP0000015_abnormal_ear_pigmentation1.75385833
28MP0005084_abnormal_gallbladder_morpholo1.61490747
29MP0010329_abnormal_lipoprotein_level1.59819208
30MP0000049_abnormal_middle_ear1.58245335
31MP0005387_immune_system_phenotype1.55531674
32MP0001790_abnormal_immune_system1.55531674
33MP0001986_abnormal_taste_sensitivity1.51470494
34MP0009643_abnormal_urine_homeostasis1.45541001
35MP0008469_abnormal_protein_level1.45079296
36MP0000685_abnormal_immune_system1.43645544
37MP0002132_abnormal_respiratory_system1.42494592
38MP0002277_abnormal_respiratory_mucosa1.39223589
39MP0003938_abnormal_ear_development1.37749290
40MP0002095_abnormal_skin_pigmentation1.37572622
41MP0005670_abnormal_white_adipose1.37146119
42MP0001800_abnormal_humoral_immune1.36870562
43MP0002163_abnormal_gland_morphology1.36733253
44MP0001919_abnormal_reproductive_system1.36423897
45MP0002723_abnormal_immune_serum1.35177087
46MP0003718_maternal_effect1.32812544
47MP0005464_abnormal_platelet_physiology1.32371135
48MP0004019_abnormal_vitamin_homeostasis1.30880786
49MP0001542_abnormal_bone_strength1.30467578
50MP0000613_abnormal_salivary_gland1.30276320
51MP0001845_abnormal_inflammatory_respons1.29426490
52MP0009250_abnormal_appendicular_skeleto1.28788521
53MP0006082_CNS_inflammation1.27999232
54MP0002177_abnormal_outer_ear1.27534840
55MP0003186_abnormal_redox_activity1.26842826
56MP0002452_abnormal_antigen_presenting1.25716383
57MP0002938_white_spotting1.24601754
58MP0001666_abnormal_nutrient_absorption1.23981467
59MP0005379_endocrine/exocrine_gland_phen1.23184777
60MP0003868_abnormal_feces_composition1.19714390
61MP0005319_abnormal_enzyme/_coenzyme1.19462678
62MP0002254_reproductive_system_inflammat1.18630865
63MP0003828_pulmonary_edema1.16948322
64MP0003191_abnormal_cellular_cholesterol1.16404677
65MP0003786_premature_aging1.15893859
66MP0005171_absent_coat_pigmentation1.14769119
67MP0002148_abnormal_hypersensitivity_rea1.14517562
68MP0005085_abnormal_gallbladder_physiolo1.11330612
69MP0008007_abnormal_cellular_replicative1.11251376
70MP0009785_altered_susceptibility_to1.11102875
71MP0002118_abnormal_lipid_homeostasis1.10643089
72MP0010155_abnormal_intestine_physiology1.10528621
73MP0002420_abnormal_adaptive_immunity1.08791067
74MP0001819_abnormal_immune_cell1.08086136
75MP0002876_abnormal_thyroid_physiology1.07422826
76MP0001756_abnormal_urination1.06587931
77MP0000490_abnormal_crypts_of1.06573243
78MP0005645_abnormal_hypothalamus_physiol1.06517066
79MP0001661_extended_life_span1.06328201
80MP0005408_hypopigmentation1.05881916
81MP0003866_abnormal_defecation1.05230534
82MP0002009_preneoplasia1.04791447
83MP0000609_abnormal_liver_physiology1.03300951
84MP0005595_abnormal_vascular_smooth0.96377378
85MP0004147_increased_porphyrin_level0.96120276
86MP0009697_abnormal_copulation0.95998554
87MP0008875_abnormal_xenobiotic_pharmacok0.94726088
88MP0000538_abnormal_urinary_bladder0.91591355
89MP0001533_abnormal_skeleton_physiology0.90426984
90MP0000689_abnormal_spleen_morphology0.89895486
91MP0003172_abnormal_lysosome_physiology0.89779811
92MP0005257_abnormal_intraocular_pressure0.89343457
93MP0008872_abnormal_physiological_respon0.89105928
94MP0002933_joint_inflammation0.88942243
95MP0001873_stomach_inflammation0.88391149
96MP0002638_abnormal_pupillary_reflex0.88373321
97MP0003195_calcinosis0.87942405
98MP0003763_abnormal_thymus_physiology0.87863122
99MP0005636_abnormal_mineral_homeostasis0.87564935
100MP0003436_decreased_susceptibility_to0.87396939
101MP0003075_altered_response_to0.87368331
102MP0000467_abnormal_esophagus_morphology0.87288752
103MP0005646_abnormal_pituitary_gland0.87222183
104* MP0009763_increased_sensitivity_to0.87090475
105MP0005025_abnormal_response_to0.85084467
106MP0002160_abnormal_reproductive_system0.83805176
107MP0009333_abnormal_splenocyte_physiolog0.82723127
108MP0008932_abnormal_embryonic_tissue0.82062967
109MP0003303_peritoneal_inflammation0.81832460
110MP0005360_urolithiasis0.81360596
111MP0002098_abnormal_vibrissa_morphology0.81021061
112MP0005584_abnormal_enzyme/coenzyme_acti0.80794511
113MP0005671_abnormal_response_to0.80766697
114MP0003638_abnormal_response/metabolism_0.79851511
115MP0005389_reproductive_system_phenotype0.79692874
116MP0000762_abnormal_tongue_morphology0.79642752
117MP0000716_abnormal_immune_system0.79313351
118MP0000681_abnormal_thyroid_gland0.78907273
119MP0008995_early_reproductive_senescence0.78236140
120MP0002136_abnormal_kidney_physiology0.78125822
121MP0001346_abnormal_lacrimal_gland0.77993707
122MP0010030_abnormal_orbit_morphology0.77973586
123MP0003880_abnormal_central_pattern0.77714366
124MP0008260_abnormal_autophagy0.77618419
125MP0002796_impaired_skin_barrier0.77513358
126MP0004142_abnormal_muscle_tone0.77512276
127MP0000343_altered_response_to0.76598793
128* MP0009642_abnormal_blood_homeostasis0.75403646
129MP0003879_abnormal_hair_cell0.75335914
130MP0002751_abnormal_autonomic_nervous0.75287856
131MP0000026_abnormal_inner_ear0.74818075
132MP0001853_heart_inflammation0.74547452
133MP0006035_abnormal_mitochondrial_morpho0.73586243
134MP0009764_decreased_sensitivity_to0.73455922
135MP0008058_abnormal_DNA_repair0.72788280
136MP0008789_abnormal_olfactory_epithelium0.71982169
137MP0003385_abnormal_body_wall0.71504735
138MP0002722_abnormal_immune_system0.70408006
139MP0004133_heterotaxia0.70314012
140MP0005000_abnormal_immune_tolerance0.68929575
141MP0002429_abnormal_blood_cell0.68163888
142MP0009384_cardiac_valve_regurgitation0.67746992
143MP0000465_gastrointestinal_hemorrhage0.67574249
144MP0002282_abnormal_trachea_morphology0.67319214
145MP0001243_abnormal_dermal_layer0.66093592
146MP0010386_abnormal_urinary_bladder0.65863695
147MP0009053_abnormal_anal_canal0.65548951
148MP0001663_abnormal_digestive_system0.65470582
149MP0005451_abnormal_body_composition0.64927595
150MP0002419_abnormal_innate_immunity0.63368764
151MP0005501_abnormal_skin_physiology0.62710991
152MP0003315_abnormal_perineum_morphology0.61230456
153MP0003936_abnormal_reproductive_system0.61164486
154MP0000678_abnormal_parathyroid_gland0.60383061
155MP0001764_abnormal_homeostasis0.59861911
156MP0001286_abnormal_eye_development0.59518572
157MP0000579_abnormal_nail_morphology0.57845775
158MP0001984_abnormal_olfaction0.57570896
159MP0000631_abnormal_neuroendocrine_gland0.56988678
160MP0009765_abnormal_xenobiotic_induced0.56509576
161MP0001835_abnormal_antigen_presentation0.56124061

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.38664146
2Aplasia/Hypoplasia of the sacrum (HP:0008517)3.95359721
3Reduced antithrombin III activity (HP:0001976)3.82754336
4Type I transferrin isoform profile (HP:0003642)3.74942615
5Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.73839613
63-Methylglutaconic aciduria (HP:0003535)3.68891764
7Abnormality of cells of the erythroid lineage (HP:0012130)3.62121693
8Systemic lupus erythematosus (HP:0002725)3.60490537
9Macrocytic anemia (HP:0001972)3.55162258
10Abnormal number of erythroid precursors (HP:0012131)3.42928922
11Prolonged partial thromboplastin time (HP:0003645)3.38149644
12Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.33058299
13Abnormality of the axillary hair (HP:0100134)3.29160781
14Abnormality of secondary sexual hair (HP:0009888)3.29160781
15Increased hepatocellular lipid droplets (HP:0006565)3.18890269
16Renal Fanconi syndrome (HP:0001994)3.16910913
17Abnormal hemoglobin (HP:0011902)3.09029680
18Prolonged neonatal jaundice (HP:0006579)3.01618473
19Complement deficiency (HP:0004431)2.93020485
20Progressive macrocephaly (HP:0004481)2.92238451
21Concave nail (HP:0001598)2.90991107
22Lipid accumulation in hepatocytes (HP:0006561)2.89669440
23Abnormality of dicarboxylic acid metabolism (HP:0010995)2.84037609
24Dicarboxylic aciduria (HP:0003215)2.84037609
25Elevated erythrocyte sedimentation rate (HP:0003565)2.83321709
26Generalized aminoaciduria (HP:0002909)2.83041592
27Congenital, generalized hypertrichosis (HP:0004540)2.80979281
28Pallor (HP:0000980)2.77746640
29Dry hair (HP:0011359)2.67684282
30Hepatocellular necrosis (HP:0001404)2.67363121
31Exertional dyspnea (HP:0002875)2.65592661
32Parakeratosis (HP:0001036)2.63445270
33Abnormal sex determination (HP:0012244)2.62455570
34Sex reversal (HP:0012245)2.62455570
35Mitochondrial inheritance (HP:0001427)2.59171386
36Abnormality of glycolipid metabolism (HP:0010969)2.56589725
37Abnormality of liposaccharide metabolism (HP:0010968)2.56589725
38Abnormality of glycosphingolipid metabolism (HP:0004343)2.56589725
39Microvesicular hepatic steatosis (HP:0001414)2.54497846
40Cerebral palsy (HP:0100021)2.54194397
41Absent rod-and cone-mediated responses on ERG (HP:0007688)2.54105448
42Lactic acidosis (HP:0003128)2.51252711
43Abnormal pupillary function (HP:0007686)2.50156421
44Increased serum ferritin (HP:0003281)2.42317979
45Abnormality of aromatic amino acid family metabolism (HP:0004338)2.41504356
46Hepatic necrosis (HP:0002605)2.41141532
47Hyperammonemia (HP:0001987)2.38668861
48Abnormal glycosylation (HP:0012345)2.38517621
49Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.38517621
50Abnormal protein N-linked glycosylation (HP:0012347)2.38517621
51Abnormal protein glycosylation (HP:0012346)2.38517621
52Abnormality of aspartate family amino acid metabolism (HP:0010899)2.37347279
53Triphalangeal thumb (HP:0001199)2.35225988
54Optic disc pallor (HP:0000543)2.32391288
55Acute necrotizing encephalopathy (HP:0006965)2.27888222
56Decreased electroretinogram (ERG) amplitude (HP:0000654)2.27385078
57Hypothermia (HP:0002045)2.23749799
58Aplasia/hypoplasia of the uterus (HP:0008684)2.21878261
59Thyroid-stimulating hormone excess (HP:0002925)2.20721320
60Partial duplication of thumb phalanx (HP:0009944)2.20240240
61Exercise intolerance (HP:0003546)2.19947265
62Petechiae (HP:0000967)2.19351822
63Hypoplasia of the radius (HP:0002984)2.18868623
64Purpura (HP:0000979)2.18645125
65Abnormality of glycine metabolism (HP:0010895)2.18358903
66Abnormality of serine family amino acid metabolism (HP:0010894)2.18358903
67Supernumerary spleens (HP:0009799)2.18323586
68Partial duplication of the phalanx of hand (HP:0009999)2.18184575
69Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.16079800
70Abnormality of complement system (HP:0005339)2.15750285
71Nonprogressive disorder (HP:0003680)2.14286841
72Abnormality of fatty-acid metabolism (HP:0004359)2.14172775
73Progressive neurologic deterioration (HP:0002344)2.13759956
74Adrenal hypoplasia (HP:0000835)2.12598662
75Increased CSF lactate (HP:0002490)2.11033468
76Progressive external ophthalmoplegia (HP:0000590)2.10704275
77True hermaphroditism (HP:0010459)2.08720286
78Respiratory failure (HP:0002878)2.07879460
79Microcytic anemia (HP:0001935)2.07436234
80Patchy hypopigmentation of hair (HP:0011365)2.07427734
81Hyperglycinuria (HP:0003108)2.07184901
82Abnormality of monocarboxylic acid metabolism (HP:0010996)2.06364444
83Metabolic acidosis (HP:0001942)2.06207213
84Conical tooth (HP:0000698)2.05709274
85Methylmalonic aciduria (HP:0012120)2.04127298
86Joint hemorrhage (HP:0005261)2.02837339
87Hypobetalipoproteinemia (HP:0003563)2.02767264
88Decreased activity of mitochondrial respiratory chain (HP:0008972)2.02723051
89Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.02723051
90Agammaglobulinemia (HP:0004432)2.02565657
91Testicular atrophy (HP:0000029)2.02188800
92Abnormality of pyrimidine metabolism (HP:0004353)2.01912765
93Abnormality of renal resorption (HP:0011038)2.01806992
94Opisthotonus (HP:0002179)2.01407242
95Aplastic anemia (HP:0001915)2.00236382
96Abnormality of iron homeostasis (HP:0011031)2.00169533
97Sparse eyelashes (HP:0000653)2.00030295
98Increased intramyocellular lipid droplets (HP:0012240)1.99945871
99Vacuolated lymphocytes (HP:0001922)1.99767586
100White forelock (HP:0002211)1.99645152
101Attenuation of retinal blood vessels (HP:0007843)1.98189957
102Abnormal respiratory motile cilium morphology (HP:0005938)1.97561854
103Abnormal respiratory epithelium morphology (HP:0012253)1.97561854
104Acute encephalopathy (HP:0006846)1.97489098
105Recurrent gram-negative bacterial infections (HP:0005420)1.97485858
106Split foot (HP:0001839)1.95698582
107Methylmalonic acidemia (HP:0002912)1.95373081
108Nausea (HP:0002018)1.94611272
109Delayed CNS myelination (HP:0002188)1.94134726
110IgG deficiency (HP:0004315)1.93715042
111Prostate neoplasm (HP:0100787)1.92694888
112Chronic sinusitis (HP:0011109)1.91170871
113Ketosis (HP:0001946)1.90688977
114Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.90194031
115Abnormality of alanine metabolism (HP:0010916)1.90194031
116Hyperalaninemia (HP:0003348)1.90194031
117Beaking of vertebral bodies (HP:0004568)1.90137765
118Duplication of thumb phalanx (HP:0009942)1.89836615
119Neutropenia (HP:0001875)1.89118680
120Congenital sensorineural hearing impairment (HP:0008527)1.88425770
121Deep venous thrombosis (HP:0002625)1.87734332
122Hyperglycinemia (HP:0002154)1.87633480
123Stomatitis (HP:0010280)1.87388916
124Hyperlipoproteinemia (HP:0010980)1.86950420
125Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.85100307
126Abnormality of transition element cation homeostasis (HP:0011030)1.83421547
127Increased serum lactate (HP:0002151)1.80845049
128Dynein arm defect of respiratory motile cilia (HP:0012255)1.80168595
129Absent/shortened dynein arms (HP:0200106)1.80168595
130Vomiting (HP:0002013)1.80032389
131Nasolacrimal duct obstruction (HP:0000579)1.79155096
132Abnormality of serum amino acid levels (HP:0003112)1.77008482
133Abnormal mitochondria in muscle tissue (HP:0008316)1.76783281
134Recurrent sinusitis (HP:0011108)1.76311722
135Glomerulonephritis (HP:0000099)1.75604624
136Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.74999095
137Abnormality of sulfur amino acid metabolism (HP:0004339)1.74558521
138Respiratory difficulties (HP:0002880)1.73797061
139Asplenia (HP:0001746)1.72355426
140Absent thumb (HP:0009777)1.72225363
141Abnormality of methionine metabolism (HP:0010901)1.71308626
142Cerebral edema (HP:0002181)1.70747680
143Muscle fiber atrophy (HP:0100295)1.70742458
144Bile duct proliferation (HP:0001408)1.70565693
145Abnormal biliary tract physiology (HP:0012439)1.70565693
146Renal tubular dysfunction (HP:0000124)1.70478246
147Abnormality of dental color (HP:0011073)1.70392653
148Abnormality of magnesium homeostasis (HP:0004921)1.68697039
149Abnormality of the phalanges of the hallux (HP:0010057)1.67933999
150Increased muscle lipid content (HP:0009058)1.66765098
151Pancytopenia (HP:0001876)1.65927717
152Absent septum pellucidum (HP:0001331)1.65609201
153Male pseudohermaphroditism (HP:0000037)1.64288932
154Anhidrosis (HP:0000970)1.64029681
155Hyperphosphaturia (HP:0003109)1.62637265
156Glycosuria (HP:0003076)1.62293608
157Abnormality of urine glucose concentration (HP:0011016)1.62293608
158Lethargy (HP:0001254)1.62220891

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.77630755
2CASK4.22641526
3TLK13.94759659
4VRK23.70850836
5STK163.35426669
6MKNK23.32867424
7TNIK2.60808803
8MUSK2.56564218
9MKNK12.47745907
10PIM22.45484690
11LIMK12.36908389
12TESK12.30197335
13NLK2.08611317
14MAP4K12.03760222
15BLK1.89941607
16TAOK31.86819698
17SRPK11.83092456
18IRAK41.76794989
19PBK1.75687239
20IRAK31.71560056
21ARAF1.71311218
22FES1.65567769
23CLK11.55069805
24MAPK151.52199502
25EIF2AK11.52129427
26ERN11.47105583
27TEC1.44533604
28MAPKAPK31.41449005
29MAP3K121.40523078
30YES11.39856434
31BCKDK1.36765027
32BUB11.35141898
33MAP4K21.32957429
34VRK11.28975406
35PRKD21.28553732
36TYK21.27454998
37IRAK11.27185297
38EIF2AK31.26547684
39TXK1.26244258
40GRK61.25114109
41MST41.24017206
42TNK21.23921593
43DYRK31.22691340
44MAP3K31.22533935
45JAK31.20500773
46CDK191.17380992
47EIF2AK21.16452387
48GRK11.14345906
49NUAK11.10660498
50PASK1.07922992
51IRAK21.05974415
52ILK1.05487733
53BMPR1B1.04919103
54LRRK21.03432800
55ADRBK21.01003870
56MAP2K31.00600098
57RPS6KB21.00256853
58EPHA20.95240316
59GRK70.94783023
60IKBKB0.94720101
61WEE10.87237862
62KIT0.85965850
63NEK10.85323187
64CSK0.83105618
65PRPF4B0.82986842
66INSRR0.81990737
67FER0.81335553
68KDR0.81214756
69PIK3CG0.81141200
70CSF1R0.79274595
71IKBKE0.77013070
72MAPKAPK50.75982884
73PKN10.75603231
74TAF10.74885067
75TAOK20.74400940
76MATK0.74181760
77MAP2K20.73379900
78SYK0.72993354
79CDK70.71654536
80PRKCI0.71616994
81MAPK130.71258720
82FLT30.71010791
83STK390.70516621
84MAPK40.70307310
85TESK20.70265988
86BTK0.70142842
87NEK90.68229577
88DYRK20.67240423
89SCYL20.66610848
90LYN0.65874215
91RPS6KA50.64488583
92OBSCN0.63904959
93DAPK30.63767926
94DYRK1B0.62647467
95MAP2K70.60494349
96MAP3K140.59820920
97TIE10.59471592
98CAMK2B0.57162151
99MAP3K110.57033162
100ITK0.56390723
101PRKCQ0.56063238
102PIM10.56051447
103TGFBR20.55285128
104PRKG20.54024658
105CSNK2A10.52669107
106CSNK1G10.51854583
107AURKA0.50812697
108CAMK10.50631889
109STK240.50405670
110LCK0.50252319
111HIPK20.48897054
112ABL20.45531669
113CDK80.45480322
114CDK90.45440810
115PRKCD0.44296092
116NEK60.43876950
117PAK10.43789662
118ZAK0.42186937
119BMPR20.41777007
120CSNK2A20.41726808
121CDK30.41361243
122NME10.41305632
123CAMK2G0.41041937
124TBK10.40486035
125PIK3CA0.40447054
126MYLK0.39663664
127CDC70.39073529
128ACVR1B0.38611573
129MAPK110.37913945
130CAMK2D0.37528572
131MAP3K130.37450009
132ADRBK10.36500498
133PRKCA0.35795040
134CCNB10.35078537
135CSNK1A10.34277487
136AURKB0.34092841
137CSNK1G30.33726346
138GRK50.32919329
139MAP2K60.32482910
140RPS6KA60.30724527
141ZAP700.30639618
142PINK10.30506199
143RPS6KL10.29907629
144RPS6KC10.29907629
145CHUK0.29180329
146IGF1R0.26541411

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.72474913
2Protein export_Homo sapiens_hsa030603.16987159
3RNA polymerase_Homo sapiens_hsa030202.46026203
4Homologous recombination_Homo sapiens_hsa034402.26051435
5Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.14270745
6Sulfur relay system_Homo sapiens_hsa041222.06784453
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.98607365
8Oxidative phosphorylation_Homo sapiens_hsa001901.94033767
9Folate biosynthesis_Homo sapiens_hsa007901.92591844
10DNA replication_Homo sapiens_hsa030301.91544817
11Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.86961393
12Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.81280365
13Fanconi anemia pathway_Homo sapiens_hsa034601.80982245
14Pyrimidine metabolism_Homo sapiens_hsa002401.77107663
15Pentose and glucuronate interconversions_Homo sapiens_hsa000401.71570207
16Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.70739182
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.69582595
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.66641134
19Steroid hormone biosynthesis_Homo sapiens_hsa001401.62265475
20Arachidonic acid metabolism_Homo sapiens_hsa005901.61440389
21Chemical carcinogenesis_Homo sapiens_hsa052041.61219921
22One carbon pool by folate_Homo sapiens_hsa006701.59441602
23Primary bile acid biosynthesis_Homo sapiens_hsa001201.57701610
24Retinol metabolism_Homo sapiens_hsa008301.57045299
25Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.52909025
26Parkinsons disease_Homo sapiens_hsa050121.51408216
27Fatty acid elongation_Homo sapiens_hsa000621.47697448
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.46972856
29Histidine metabolism_Homo sapiens_hsa003401.46902956
30Basal transcription factors_Homo sapiens_hsa030221.45250914
31Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.41140608
32Proteasome_Homo sapiens_hsa030501.37679077
33Arginine biosynthesis_Homo sapiens_hsa002201.36980208
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.36351851
35Phenylalanine metabolism_Homo sapiens_hsa003601.35735857
36Other glycan degradation_Homo sapiens_hsa005111.31930557
37Mismatch repair_Homo sapiens_hsa034301.29537523
38Butanoate metabolism_Homo sapiens_hsa006501.29414174
39Nucleotide excision repair_Homo sapiens_hsa034201.27885129
40Pentose phosphate pathway_Homo sapiens_hsa000301.26688868
41Caffeine metabolism_Homo sapiens_hsa002321.26358762
42Cyanoamino acid metabolism_Homo sapiens_hsa004601.25731494
43Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.25593252
44Sphingolipid metabolism_Homo sapiens_hsa006001.22680960
45Spliceosome_Homo sapiens_hsa030401.22486572
46Pyruvate metabolism_Homo sapiens_hsa006201.20641184
47Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.19452170
48Carbon metabolism_Homo sapiens_hsa012001.15405840
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.15285580
50Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.12691552
51Complement and coagulation cascades_Homo sapiens_hsa046101.11771735
52Base excision repair_Homo sapiens_hsa034101.11535163
53Galactose metabolism_Homo sapiens_hsa000521.10521835
54Glutathione metabolism_Homo sapiens_hsa004801.10279880
55Huntingtons disease_Homo sapiens_hsa050161.10085007
56Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.08053428
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.07663108
58Purine metabolism_Homo sapiens_hsa002301.06139525
59Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.05017279
60Alzheimers disease_Homo sapiens_hsa050101.01179783
61Biosynthesis of amino acids_Homo sapiens_hsa012301.00807679
62Peroxisome_Homo sapiens_hsa041460.99510740
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.97428200
64Propanoate metabolism_Homo sapiens_hsa006400.96376895
65Maturity onset diabetes of the young_Homo sapiens_hsa049500.95588962
66Drug metabolism - other enzymes_Homo sapiens_hsa009830.94671880
67beta-Alanine metabolism_Homo sapiens_hsa004100.92388523
68Malaria_Homo sapiens_hsa051440.90947225
69Linoleic acid metabolism_Homo sapiens_hsa005910.88431286
70Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.87676198
71Non-homologous end-joining_Homo sapiens_hsa034500.86981744
72Glycosaminoglycan degradation_Homo sapiens_hsa005310.83196774
73PPAR signaling pathway_Homo sapiens_hsa033200.79693231
74Fat digestion and absorption_Homo sapiens_hsa049750.79471923
75Staphylococcus aureus infection_Homo sapiens_hsa051500.78856085
76Hematopoietic cell lineage_Homo sapiens_hsa046400.78762708
77Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.78715598
78Phototransduction_Homo sapiens_hsa047440.77773010
79Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.76776251
80Arginine and proline metabolism_Homo sapiens_hsa003300.76576212
81Metabolic pathways_Homo sapiens_hsa011000.73674084
82p53 signaling pathway_Homo sapiens_hsa041150.71811957
83Primary immunodeficiency_Homo sapiens_hsa053400.71483901
84Allograft rejection_Homo sapiens_hsa053300.67792784
85Ether lipid metabolism_Homo sapiens_hsa005650.65630772
86Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.65267488
87Vitamin digestion and absorption_Homo sapiens_hsa049770.65182174
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.63204062
89Intestinal immune network for IgA production_Homo sapiens_hsa046720.62752544
90Type I diabetes mellitus_Homo sapiens_hsa049400.62232506
91Graft-versus-host disease_Homo sapiens_hsa053320.61635998
92Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61164776
93Rheumatoid arthritis_Homo sapiens_hsa053230.60740097
94Collecting duct acid secretion_Homo sapiens_hsa049660.60523209
95alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.60355765
96Tryptophan metabolism_Homo sapiens_hsa003800.59189930
97RNA degradation_Homo sapiens_hsa030180.56518012
98Autoimmune thyroid disease_Homo sapiens_hsa053200.55425691
99Lysosome_Homo sapiens_hsa041420.55402741
100RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.55096517
101Tyrosine metabolism_Homo sapiens_hsa003500.54143632
102Antigen processing and presentation_Homo sapiens_hsa046120.54081004
103SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53805659
104Sulfur metabolism_Homo sapiens_hsa009200.52806747
105Basal cell carcinoma_Homo sapiens_hsa052170.52758404
106Cardiac muscle contraction_Homo sapiens_hsa042600.52413913
107NF-kappa B signaling pathway_Homo sapiens_hsa040640.51721243
108Fatty acid metabolism_Homo sapiens_hsa012120.50049049
109Steroid biosynthesis_Homo sapiens_hsa001000.50031673
110Thyroid cancer_Homo sapiens_hsa052160.49912875
111Jak-STAT signaling pathway_Homo sapiens_hsa046300.45876497
112Fructose and mannose metabolism_Homo sapiens_hsa000510.45787687
113Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43508338
114Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.41667486
115Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.41083811
116Systemic lupus erythematosus_Homo sapiens_hsa053220.40691866
117Herpes simplex infection_Homo sapiens_hsa051680.39949453
118Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.39940537
119Glycerolipid metabolism_Homo sapiens_hsa005610.39207532
120Pertussis_Homo sapiens_hsa051330.38732583
121Asthma_Homo sapiens_hsa053100.38711813
122Fatty acid degradation_Homo sapiens_hsa000710.37029524
123Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36224322
124Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.35227070
125Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.34624078
126Selenocompound metabolism_Homo sapiens_hsa004500.32150940
127Starch and sucrose metabolism_Homo sapiens_hsa005000.31978382

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