MGAT4D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)9.92147019
2binding of sperm to zona pellucida (GO:0007339)9.86974376
3motile cilium assembly (GO:0044458)9.64927985
4acrosome reaction (GO:0007340)9.31171420
5epithelial cilium movement (GO:0003351)9.06338727
6male meiosis (GO:0007140)8.94344551
7spermatid development (GO:0007286)8.41547556
8epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.15417145
9cilium movement (GO:0003341)8.01838486
10single fertilization (GO:0007338)7.80530718
11synaptonemal complex organization (GO:0070193)7.63615755
12synaptonemal complex assembly (GO:0007130)7.34375236
13regulation of cilium movement (GO:0003352)6.76072606
14sphingosine metabolic process (GO:0006670)6.71139084
15cellular ketone body metabolic process (GO:0046950)6.54671538
16sperm capacitation (GO:0048240)6.45908001
17sphingoid metabolic process (GO:0046519)6.44404838
18fertilization (GO:0009566)6.42810374
19DNA methylation involved in gamete generation (GO:0043046)6.35526768
20diol metabolic process (GO:0034311)6.15482134
21ketone body metabolic process (GO:1902224)5.76894428
22kynurenine metabolic process (GO:0070189)5.46017015
23male meiosis I (GO:0007141)5.44282977
24spermatogenesis (GO:0007283)5.38486910
25male gamete generation (GO:0048232)5.36485156
26chromosome organization involved in meiosis (GO:0070192)5.30326453
27regulation of pigment cell differentiation (GO:0050932)5.29105769
28microtubule depolymerization (GO:0007019)5.28605130
29somite rostral/caudal axis specification (GO:0032525)5.23179236
30ventricular system development (GO:0021591)5.22045243
31tryptophan catabolic process (GO:0006569)5.12844190
32indole-containing compound catabolic process (GO:0042436)5.12844190
33indolalkylamine catabolic process (GO:0046218)5.12844190
34meiotic nuclear division (GO:0007126)5.11410743
35regulation of memory T cell differentiation (GO:0043380)5.10885869
36negative regulation of inclusion body assembly (GO:0090084)5.10086863
37cell recognition (GO:0008037)5.08762371
38cellular process involved in reproduction in multicellular organism (GO:0022412)5.08180552
39sulfate transmembrane transport (GO:1902358)5.02862079
40gamete generation (GO:0007276)4.96536369
41sex differentiation (GO:0007548)4.89581884
42germ cell development (GO:0007281)4.88091765
43regulation of interleukin-5 production (GO:0032674)4.87168515
44spermatid nucleus differentiation (GO:0007289)4.70989730
45calcium ion-dependent exocytosis (GO:0017156)4.68386169
46organic cation transport (GO:0015695)4.65437038
47indolalkylamine metabolic process (GO:0006586)4.60569186
48protein-chromophore linkage (GO:0018298)4.59467552
49negative regulation of multicellular organism growth (GO:0040015)4.38441410
50sulfate transport (GO:0008272)4.38354577
51reciprocal meiotic recombination (GO:0007131)4.37856235
52reciprocal DNA recombination (GO:0035825)4.37856235
53meiosis I (GO:0007127)4.37530533
54regulation of odontogenesis of dentin-containing tooth (GO:0042487)4.37411200
55protein localization to cilium (GO:0061512)4.31937460
56regulation of inclusion body assembly (GO:0090083)4.23377641
57meiotic cell cycle (GO:0051321)4.23025235
58monoubiquitinated protein deubiquitination (GO:0035520)4.12256352
59regulation of establishment of cell polarity (GO:2000114)4.09002115
60microtubule severing (GO:0051013)4.05102238
61seminiferous tubule development (GO:0072520)4.01899168
62tryptophan metabolic process (GO:0006568)3.99190308
63positive regulation of developmental pigmentation (GO:0048087)3.94131097
64cytoplasmic mRNA processing body assembly (GO:0033962)3.93859968
65regulation of microtubule-based movement (GO:0060632)3.93329342
66multicellular organismal reproductive process (GO:0048609)3.88753126
67centriole assembly (GO:0098534)3.87208033
68centriole replication (GO:0007099)3.86994021
69aromatic amino acid family catabolic process (GO:0009074)3.86640806
70positive regulation of meiosis (GO:0045836)3.84391872
71gene silencing by RNA (GO:0031047)3.81398178
72meiotic chromosome segregation (GO:0045132)3.78729292
73intraciliary transport (GO:0042073)3.78261445
74regulation of MHC class I biosynthetic process (GO:0045343)3.78239351
75chaperone-mediated protein complex assembly (GO:0051131)3.78061640
76regulation of interleukin-13 production (GO:0032656)3.70538441
77regulation of establishment or maintenance of cell polarity (GO:0032878)3.67639297
78genitalia morphogenesis (GO:0035112)3.61849609
79pantothenate metabolic process (GO:0015939)3.56772336
80positive regulation of meiotic cell cycle (GO:0051446)3.56552574
81behavioral response to nicotine (GO:0035095)3.54926611
82regulation of centriole replication (GO:0046599)3.54382594
83left/right pattern formation (GO:0060972)3.44277283
84indole-containing compound metabolic process (GO:0042430)3.41454142
85negative regulation of mast cell activation (GO:0033004)3.38994652
86detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.38896949
87primary amino compound metabolic process (GO:1901160)3.38724343
88glycerol ether metabolic process (GO:0006662)3.36445774
89synapsis (GO:0007129)3.34939648
90axoneme assembly (GO:0035082)3.29716375
91regulation of posttranscriptional gene silencing (GO:0060147)3.28590324
92regulation of gene silencing by miRNA (GO:0060964)3.28590324
93regulation of gene silencing by RNA (GO:0060966)3.28590324
94microtubule-based movement (GO:0007018)3.28508217
95negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.28216288
96amine catabolic process (GO:0009310)3.24622441
97cellular biogenic amine catabolic process (GO:0042402)3.24622441
98regulation of meiosis I (GO:0060631)3.23560813
99centrosome duplication (GO:0051298)3.20891977
100aromatic amino acid family metabolic process (GO:0009072)3.18992596
101serotonin metabolic process (GO:0042428)3.18490960
102phosphatidylethanolamine metabolic process (GO:0046337)3.17619381
103amino-acid betaine transport (GO:0015838)3.17298530
104carnitine transport (GO:0015879)3.17298530
105left/right axis specification (GO:0070986)3.14351251
106alditol metabolic process (GO:0019400)3.14023323
107multicellular organismal development (GO:0007275)3.13962727
108lipopolysaccharide biosynthetic process (GO:0009103)3.13897024
109meiotic cell cycle process (GO:1903046)3.11915997
110carnitine transmembrane transport (GO:1902603)3.11814225
111cerebellar Purkinje cell differentiation (GO:0021702)3.11577952
112protein polyglutamylation (GO:0018095)3.11528639
113ether metabolic process (GO:0018904)3.10199412
114cilium organization (GO:0044782)3.08078988
115negative regulation of organelle assembly (GO:1902116)3.08002051
116lactate metabolic process (GO:0006089)3.07530754
117positive regulation of vasculogenesis (GO:2001214)3.05715415
118NAD biosynthetic process (GO:0009435)3.04515146
119heme transport (GO:0015886)3.03795579
120sterol catabolic process (GO:0016127)3.03525004
121cholesterol catabolic process (GO:0006707)3.03525004
122opioid receptor signaling pathway (GO:0038003)3.02680742
123nuclear pore complex assembly (GO:0051292)3.02396308
124phosphatidylethanolamine biosynthetic process (GO:0006646)3.01783432
125cilium morphogenesis (GO:0060271)3.00709781
126positive regulation of embryonic development (GO:0040019)2.96546497
127cilium assembly (GO:0042384)2.96361530
128cellular component assembly involved in morphogenesis (GO:0010927)2.94328976
129glycerol metabolic process (GO:0006071)2.94086476
130one-carbon compound transport (GO:0019755)2.92371183
131polyol catabolic process (GO:0046174)2.91481111
132negative regulation of type 2 immune response (GO:0002829)2.89985883
133microtubule polymerization or depolymerization (GO:0031109)2.87059128
134postsynaptic membrane organization (GO:0001941)2.83032846
135regulation of somitogenesis (GO:0014807)2.81289340
136reflex (GO:0060004)2.80733753
137regulation of rhodopsin mediated signaling pathway (GO:0022400)2.79809838
138regulation of spindle checkpoint (GO:0090231)2.79035831
139protein K11-linked deubiquitination (GO:0035871)2.77720344
140photoreceptor cell maintenance (GO:0045494)2.76599941
141neural tube formation (GO:0001841)2.75891722
142sulfur compound transport (GO:0072348)2.74860003
143behavioral response to ethanol (GO:0048149)2.72035334
144synaptic transmission, cholinergic (GO:0007271)2.71911836
145regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.69874965
146regulation of action potential (GO:0098900)2.68244655
147negative regulation of cell cycle G2/M phase transition (GO:1902750)2.66865327
148single-organism membrane fusion (GO:0044801)2.65857137
149chromosome condensation (GO:0030261)2.64907758
150regulation of protein polyubiquitination (GO:1902914)2.61045897
151nucleoside diphosphate phosphorylation (GO:0006165)2.58881565
152negative regulation of DNA repair (GO:0045738)2.55132863
153gene silencing (GO:0016458)2.53989875
154DNA packaging (GO:0006323)2.53092643
155sister chromatid cohesion (GO:0007062)2.48794181
156nucleus organization (GO:0006997)2.48400921
157regulation of podosome assembly (GO:0071801)2.39722579
158DNA methylation (GO:0006306)2.36907052
159DNA alkylation (GO:0006305)2.36907052
160mitotic sister chromatid cohesion (GO:0007064)2.36625075
161GTP biosynthetic process (GO:0006183)2.35967329
162quaternary ammonium group transport (GO:0015697)2.34052507
163cilium or flagellum-dependent cell motility (GO:0001539)15.9725548
164fusion of sperm to egg plasma membrane (GO:0007342)15.7916595
165cell wall macromolecule metabolic process (GO:0044036)14.1926242
166cell wall macromolecule catabolic process (GO:0016998)14.1926242
167multicellular organism reproduction (GO:0032504)12.8056944
168acrosome assembly (GO:0001675)12.3258915
169plasma membrane fusion (GO:0045026)12.0409372
170sperm-egg recognition (GO:0035036)11.6046570
171sperm motility (GO:0030317)10.5581410
172cell-cell recognition (GO:0009988)10.3806116
173reproduction (GO:0000003)10.3153099
174axonemal dynein complex assembly (GO:0070286)10.2378030

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.77330954
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.63960060
3EZH2_22144423_ChIP-Seq_EOC_Human4.18477987
4GBX2_23144817_ChIP-Seq_PC3_Human2.88683284
5IGF1R_20145208_ChIP-Seq_DFB_Human2.78974568
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.71055020
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.62431281
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.56089353
9AR_21572438_ChIP-Seq_LNCaP_Human2.43064806
10CTBP1_25329375_ChIP-Seq_LNCAP_Human2.36986997
11PCGF2_27294783_Chip-Seq_ESCs_Mouse2.35173863
12ZNF274_21170338_ChIP-Seq_K562_Hela2.28007019
13CBX2_27304074_Chip-Seq_ESCs_Mouse2.15838326
14KAP1_22055183_ChIP-Seq_ESCs_Mouse2.09613735
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.02142142
16CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.01106037
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.00412837
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse11.0207391
19EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.96107444
20ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.92170542
21TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.90937562
22KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.88198941
23ELK4_26923725_Chip-Seq_MESODERM_Mouse1.87445942
24DROSHA_22980978_ChIP-Seq_HELA_Human1.78686105
25BMI1_23680149_ChIP-Seq_NPCS_Mouse1.74375412
26RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.74195369
27P300_19829295_ChIP-Seq_ESCs_Human1.68933138
28PCGF2_27294783_Chip-Seq_NPCs_Mouse1.67753641
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.67586782
30FUS_26573619_Chip-Seq_HEK293_Human1.67523567
31STAT3_23295773_ChIP-Seq_U87_Human1.67003665
32GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.66812846
33RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66764956
34TAL1_26923725_Chip-Seq_HPCs_Mouse1.63486331
35KDM2B_26808549_Chip-Seq_REH_Human1.62963181
36POU3F2_20337985_ChIP-ChIP_501MEL_Human1.62152853
37NFE2_27457419_Chip-Seq_LIVER_Mouse1.62135563
38WDR5_24793694_ChIP-Seq_LNCAP_Human1.61545423
39SUZ12_27294783_Chip-Seq_NPCs_Mouse1.59460198
40SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.58969647
41VDR_22108803_ChIP-Seq_LS180_Human1.58318449
42STAT1_17558387_ChIP-Seq_HELA_Human1.55790934
43GATA1_26923725_Chip-Seq_HPCs_Mouse1.54536727
44TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.51783349
45UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.51326724
46AR_25329375_ChIP-Seq_VCAP_Human1.48011964
47MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.47721107
48SMAD4_21741376_ChIP-Seq_EPCs_Human1.47115164
49OCT1_27270436_Chip-Seq_PROSTATE_Human1.47044588
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44943502
51FLI1_21867929_ChIP-Seq_TH2_Mouse1.43284073
52CRX_20693478_ChIP-Seq_RETINA_Mouse1.43143092
53TDRD3_21172665_ChIP-Seq_MCF-7_Human1.41005601
54BCAT_22108803_ChIP-Seq_LS180_Human1.39901033
55STAT6_21828071_ChIP-Seq_BEAS2B_Human1.39815550
56GATA3_21867929_ChIP-Seq_CD8_Mouse1.37781774
57SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.37075486
58EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.36980393
59CBP_20019798_ChIP-Seq_JUKART_Human1.35812966
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35812966
61SMAD4_21799915_ChIP-Seq_A2780_Human1.35459225
62OCT4_18555785_Chip-Seq_ESCs_Mouse1.34247668
63EZH2_27294783_Chip-Seq_NPCs_Mouse1.34242773
64LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.33905586
65MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.33393859
66NANOG_18555785_Chip-Seq_ESCs_Mouse1.33282396
67FOXA1_27270436_Chip-Seq_PROSTATE_Human1.33112160
68FOXA1_25329375_ChIP-Seq_VCAP_Human1.33112160
69JARID2_20075857_ChIP-Seq_MESCs_Mouse1.30630446
70PIAS1_25552417_ChIP-Seq_VCAP_Human1.29523214
71TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28790346
72EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.27676813
73CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.26857849
74OCT4_20526341_ChIP-Seq_ESCs_Human1.26854073
75SMAD3_21741376_ChIP-Seq_EPCs_Human1.26815313
76MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26719432
77EZH2_27304074_Chip-Seq_ESCs_Mouse1.26641683
78P300_18555785_Chip-Seq_ESCs_Mouse1.25433435
79GATA3_21878914_ChIP-Seq_MCF-7_Human1.25243377
80CMYC_18555785_Chip-Seq_ESCs_Mouse1.25199294
81NR3C1_21868756_ChIP-Seq_MCF10A_Human1.24646125
82KLF4_18555785_Chip-Seq_ESCs_Mouse1.24568488
83CTBP2_25329375_ChIP-Seq_LNCAP_Human1.24384905
84P53_22387025_ChIP-Seq_ESCs_Mouse1.23318707
85GATA3_21867929_ChIP-Seq_TH1_Mouse1.22412099
86FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22381427
87PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.22195287
88ESRRB_18555785_Chip-Seq_ESCs_Mouse1.20582964
89NANOG_19829295_ChIP-Seq_ESCs_Human1.20582725
90SOX2_19829295_ChIP-Seq_ESCs_Human1.20582725
91SOX2_22085726_ChIP-Seq_NPCs_Mouse1.18120893
92FOXA1_21572438_ChIP-Seq_LNCaP_Human1.17890475
93CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.17791440
94SUZ12_18555785_Chip-Seq_ESCs_Mouse1.17141848
95RNF2_27304074_Chip-Seq_NSC_Mouse1.17103532
96ERA_21632823_ChIP-Seq_H3396_Human1.17056302
97OCT4_21477851_ChIP-Seq_ESCs_Mouse1.16368621
98GF1_26923725_Chip-Seq_HPCs_Mouse1.16236089
99RUNX2_22187159_ChIP-Seq_PCA_Human1.15899446
100STAT3_18555785_Chip-Seq_ESCs_Mouse1.14531095
101JARID2_20064375_ChIP-Seq_MESCs_Mouse1.12512708
102VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.12202645
103TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11835888
104KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10866082
105REST_21632747_ChIP-Seq_MESCs_Mouse1.10743032
106NCOR_22424771_ChIP-Seq_293T_Human1.10560844
107SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.10526679
108HOXB7_26014856_ChIP-Seq_BT474_Human1.10521865
109RUNX1_26923725_Chip-Seq_HPCs_Mouse1.10048578
110ETV2_25802403_ChIP-Seq_MESCs_Mouse1.09512780
111PRDM14_20953172_ChIP-Seq_ESCs_Human1.09052797
112RUNX1_27457419_Chip-Seq_LIVER_Mouse1.08687779
113CTCF_18555785_Chip-Seq_ESCs_Mouse1.07992455
114RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.07802580
115SOX2_18555785_Chip-Seq_ESCs_Mouse1.07720256
116CDX2_22108803_ChIP-Seq_LS180_Human1.07269813
117CEBPB_22108803_ChIP-Seq_LS180_Human1.06276320
118EED_16625203_ChIP-ChIP_MESCs_Mouse1.05143457
119NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.04635058
120RXR_22108803_ChIP-Seq_LS180_Human1.04630494
121PU1_27457419_Chip-Seq_LIVER_Mouse1.03084598
122SMAD1_18555785_Chip-Seq_ESCs_Mouse1.03025335
123SALL1_21062744_ChIP-ChIP_HESCs_Human1.02560487
124SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.02386648
125TCF4_22108803_ChIP-Seq_LS180_Human1.02121492
126MYC_19829295_ChIP-Seq_ESCs_Human1.01742418
127E2F1_18555785_Chip-Seq_ESCs_Mouse1.01724799
128EZH2_27294783_Chip-Seq_ESCs_Mouse1.01639685
129PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.00524664
130TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.00438665
131EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.00301942
132ER_23166858_ChIP-Seq_MCF-7_Human0.99941204
133ZFX_18555785_Chip-Seq_ESCs_Mouse0.99821760
134STAT1_20625510_ChIP-Seq_HELA_Human0.99738136
135GF1B_26923725_Chip-Seq_HPCs_Mouse0.98916614
136CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98711944
137P53_21459846_ChIP-Seq_SAOS-2_Human0.98302366
138TAF2_19829295_ChIP-Seq_ESCs_Human0.98193707
139AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96937812
140LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96776525
141SMAD4_21741376_ChIP-Seq_HESCs_Human0.96072701
142AR_19668381_ChIP-Seq_PC3_Human0.96013270
143SMAD3_21741376_ChIP-Seq_ESCs_Human0.95972676
144SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.94707048
145CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.93217695
146NMYC_18555785_Chip-Seq_ESCs_Mouse0.93137008
147HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.92904359
148MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.92892244
149NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.91531682
150PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.91489495
151SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.90320591
152ESET_19884257_ChIP-Seq_ESCs_Mouse0.90067408
153TAF15_26573619_Chip-Seq_HEK293_Human0.89012378
154SPI1_26923725_Chip-Seq_HPCs_Mouse0.88917751
155STAT3_18555785_ChIP-Seq_MESCs_Mouse0.88780792
156SOX9_26525672_Chip-Seq_HEART_Mouse0.88681514
157LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.88045229
158EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.87991898
159TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87648715
160POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.87648715
161TCF4_23295773_ChIP-Seq_U87_Human0.85461887
162FLI1_21867929_ChIP-Seq_CD8_Mouse0.85384418

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color6.13203280
2MP0003698_abnormal_male_reproductive5.90000744
3MP0008877_abnormal_DNA_methylation5.84368847
4MP0002837_dystrophic_cardiac_calcinosis5.65788837
5MP0001929_abnormal_gametogenesis5.53347836
6MP0002653_abnormal_ependyma_morphology4.32399961
7MP0005171_absent_coat_pigmentation4.14024277
8MP0002210_abnormal_sex_determination3.92404539
9MP0001145_abnormal_male_reproductive3.30162298
10MP0002161_abnormal_fertility/fecundity3.19497659
11MP0000653_abnormal_sex_gland2.94818224
12MP0005085_abnormal_gallbladder_physiolo2.91561348
13MP0003252_abnormal_bile_duct2.86278559
14MP0003879_abnormal_hair_cell2.54746063
15MP0005623_abnormal_meninges_morphology2.43855744
16MP0001501_abnormal_sleep_pattern2.35701629
17MP0005174_abnormal_tail_pigmentation2.06091485
18MP0008057_abnormal_DNA_replication2.01644247
19MP0005410_abnormal_fertilization14.5579533
20MP0002138_abnormal_hepatobiliary_system1.90630763
21MP0004233_abnormal_muscle_weight1.84697095
22MP0004043_abnormal_pH_regulation1.79826203
23MP0009046_muscle_twitch1.79168399
24MP0001968_abnormal_touch/_nociception1.77886868
25MP0003195_calcinosis1.74170983
26MP0002160_abnormal_reproductive_system1.71813354
27MP0002736_abnormal_nociception_after1.68595728
28MP0002938_white_spotting1.63102769
29MP0009745_abnormal_behavioral_response1.62143471
30MP0004381_abnormal_hair_follicle1.59887308
31MP0004147_increased_porphyrin_level1.58284867
32MP0002277_abnormal_respiratory_mucosa1.58059438
33MP0005670_abnormal_white_adipose1.57812206
34MP0000015_abnormal_ear_pigmentation1.54972914
35MP0008058_abnormal_DNA_repair1.49357902
36MP0002102_abnormal_ear_morphology1.47687871
37MP0002095_abnormal_skin_pigmentation1.45503598
38MP0001984_abnormal_olfaction1.45109851
39MP0002282_abnormal_trachea_morphology1.39608345
40MP0008961_abnormal_basal_metabolism1.39349923
41MP0010094_abnormal_chromosome_stability1.37670762
42MP0002876_abnormal_thyroid_physiology1.29033282
43MP0002234_abnormal_pharynx_morphology1.26713576
44MP0003959_abnormal_lean_body1.24332451
45MP0002272_abnormal_nervous_system1.22161259
46MP0002735_abnormal_chemical_nociception1.21645676
47MP0005075_abnormal_melanosome_morpholog1.19673547
48MP0005647_abnormal_sex_gland1.19515138
49MP0002064_seizures1.18894160
50MP0006276_abnormal_autonomic_nervous1.17572581
51MP0000383_abnormal_hair_follicle1.17518938
52MP0003137_abnormal_impulse_conducting1.13810898
53MP0003646_muscle_fatigue1.12437637
54MP0002075_abnormal_coat/hair_pigmentati1.11844086
55MP0002168_other_aberrant_phenotype1.10707470
56MP0000371_diluted_coat_color1.10557474
57MP0002733_abnormal_thermal_nociception1.09059740
58MP0001986_abnormal_taste_sensitivity1.05153988
59MP0004130_abnormal_muscle_cell1.04246667
60MP0000749_muscle_degeneration1.00491537
61MP0003119_abnormal_digestive_system0.99625459
62MP0003011_delayed_dark_adaptation0.99086097
63MP0001485_abnormal_pinna_reflex0.97406637
64MP0005389_reproductive_system_phenotype0.90018374
65MP0001765_abnormal_ion_homeostasis0.89733627
66MP0002572_abnormal_emotion/affect_behav0.88873303
67MP0009379_abnormal_foot_pigmentation0.88241489
68MP0001486_abnormal_startle_reflex0.87417203
69MP0003786_premature_aging0.87377789
70MP0001970_abnormal_pain_threshold0.86666431
71MP0008007_abnormal_cellular_replicative0.85145493
72MP0003183_abnormal_peptide_metabolism0.84762470
73MP0005395_other_phenotype0.83886266
74MP0008995_early_reproductive_senescence0.80932371
75MP0000470_abnormal_stomach_morphology0.79810002
76MP0003718_maternal_effect0.77742301
77MP0005266_abnormal_metabolism0.72953311
78MP0002067_abnormal_sensory_capabilities0.72196418
79MP0001905_abnormal_dopamine_level0.72131211
80MP0002928_abnormal_bile_duct0.71506514
81MP0003950_abnormal_plasma_membrane0.67387924
82MP0001664_abnormal_digestion0.66771661
83MP0001186_pigmentation_phenotype0.66213907
84MP0003890_abnormal_embryonic-extraembry0.65182155
85MP0000427_abnormal_hair_cycle0.63727760
86MP0001119_abnormal_female_reproductive0.63406244
87MP0003635_abnormal_synaptic_transmissio0.63367048
88MP0010307_abnormal_tumor_latency0.62848087
89MP0005167_abnormal_blood-brain_barrier0.62242863
90MP0003699_abnormal_female_reproductive0.61294373
91MP0005448_abnormal_energy_balance0.60145709
92MP0001346_abnormal_lacrimal_gland0.58876168
93MP0000631_abnormal_neuroendocrine_gland0.56866704
94MP0004142_abnormal_muscle_tone0.56475110
95MP0008770_decreased_survivor_rate0.56014075
96MP0005551_abnormal_eye_electrophysiolog0.55970241
97MP0001188_hyperpigmentation0.55260491
98MP0010386_abnormal_urinary_bladder0.54497827
99MP0003111_abnormal_nucleus_morphology0.51587906
100MP0004134_abnormal_chest_morphology0.50946507
101MP0004808_abnormal_hematopoietic_stem0.49833505
102MP0002269_muscular_atrophy0.49617329
103MP0000647_abnormal_sebaceous_gland0.46450033
104MP0000358_abnormal_cell_content/0.45980541
105MP0005636_abnormal_mineral_homeostasis0.41737536
106MP0004019_abnormal_vitamin_homeostasis0.41440007
107MP0005253_abnormal_eye_physiology0.40314861
108MP0001293_anophthalmia0.40153823
109MP0001730_embryonic_growth_arrest0.38680103
110MP0001324_abnormal_eye_pigmentation0.36997359
111MP0002139_abnormal_hepatobiliary_system0.36677799
112MP0003115_abnormal_respiratory_system0.36388222
113MP0002971_abnormal_brown_adipose0.35874618
114MP0003633_abnormal_nervous_system0.33179547
115MP0003077_abnormal_cell_cycle0.32574462
116MP0003329_amyloid_beta_deposits0.30301650
117MP0003861_abnormal_nervous_system0.30056674
118MP0005391_vision/eye_phenotype0.29551501
119MP0002084_abnormal_developmental_patter0.29153123
120MP0005377_hearing/vestibular/ear_phenot0.28425329
121MP0003878_abnormal_ear_physiology0.28425329
122MP0000313_abnormal_cell_death0.27670817
123MP0002152_abnormal_brain_morphology0.27453647
124MP0006036_abnormal_mitochondrial_physio0.25989046
125MP0005365_abnormal_bile_salt0.25964907
126MP0000432_abnormal_head_morphology0.25905454
127MP0005666_abnormal_adipose_tissue0.25574371
128MP0001545_abnormal_hematopoietic_system0.25205816
129MP0005397_hematopoietic_system_phenotyp0.25205816
130MP0004036_abnormal_muscle_relaxation0.25089414
131MP0005535_abnormal_body_temperature0.24390204
132MP0002233_abnormal_nose_morphology0.23691241
133MP0002557_abnormal_social/conspecific_i0.22305940
134MP0005409_darkened_coat_color0.22274121
135MP0000569_abnormal_digit_pigmentation0.22143012
136MP0003631_nervous_system_phenotype0.21974185
137MP0009697_abnormal_copulation0.20464212
138MP0001851_eye_inflammation0.20318719
139MP0001697_abnormal_embryo_size0.20256859
140MP0009115_abnormal_fat_cell0.19981368
141MP0001672_abnormal_embryogenesis/_devel0.19889158
142MP0005380_embryogenesis_phenotype0.19889158
143MP0003045_fibrosis0.19282482
144MP0008875_abnormal_xenobiotic_pharmacok0.18775661
145MP0005195_abnormal_posterior_eye0.18565115
146MP0004811_abnormal_neuron_physiology0.18236141
147MP0003984_embryonic_growth_retardation0.17732026
148MP0001764_abnormal_homeostasis0.17722907
149MP0004133_heterotaxia0.17700688
150MP0006072_abnormal_retinal_apoptosis0.16807444
151MP0002009_preneoplasia0.16179898
152MP0002132_abnormal_respiratory_system0.15688338
153MP0008872_abnormal_physiological_respon0.15513452
154MP0002229_neurodegeneration0.15483384
155MP0003705_abnormal_hypodermis_morpholog0.15205663
156MP0002088_abnormal_embryonic_growth/wei0.14861998
157MP0005388_respiratory_system_phenotype0.14247345
158MP0002133_abnormal_respiratory_system0.14247345
159MP0001661_extended_life_span0.13868517
160MP0002970_abnormal_white_adipose0.13753724
161MP0000026_abnormal_inner_ear0.13114056

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.50104022
2Abnormal respiratory motile cilium morphology (HP:0005938)8.80132586
3Abnormal respiratory epithelium morphology (HP:0012253)8.80132586
4Rhinitis (HP:0012384)8.16104359
5Abnormal ciliary motility (HP:0012262)7.85881669
6Chronic bronchitis (HP:0004469)7.33007610
7Nasal polyposis (HP:0100582)6.40137275
8Infertility (HP:0000789)5.69729269
9Genetic anticipation (HP:0003743)5.54129550
10Amelogenesis imperfecta (HP:0000705)5.42940490
11Abnormality of the nasal mucosa (HP:0000433)5.24550439
12Focal motor seizures (HP:0011153)5.16122430
13Pendular nystagmus (HP:0012043)4.89643689
14Bronchiectasis (HP:0002110)4.67222741
15Bronchitis (HP:0012387)4.43018110
16Progressive cerebellar ataxia (HP:0002073)4.32245702
17Pancreatic cysts (HP:0001737)4.31028554
18Dialeptic seizures (HP:0011146)4.05189155
19Dysmetric saccades (HP:0000641)4.05114770
20Nephronophthisis (HP:0000090)4.03834006
21Birth length less than 3rd percentile (HP:0003561)3.80004355
22Medial flaring of the eyebrow (HP:0010747)3.79656881
23Abnormality of the hepatic vasculature (HP:0006707)3.66844430
24Severe visual impairment (HP:0001141)3.60456842
25Focal seizures (HP:0007359)3.56451145
26Chronic hepatic failure (HP:0100626)3.53307677
27Recurrent sinusitis (HP:0011108)3.50478892
28Action tremor (HP:0002345)3.41580795
29Acanthocytosis (HP:0001927)3.33526957
30Abnormality of macular pigmentation (HP:0008002)3.31036092
31Recurrent otitis media (HP:0000403)3.18968224
32Absence seizures (HP:0002121)3.18016420
33Aplasia/Hypoplasia of the uvula (HP:0010293)3.13240906
34Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.12028362
35Abnormality of the renal medulla (HP:0100957)3.09304752
36Abnormality of the lower motor neuron (HP:0002366)3.00407492
37Gait imbalance (HP:0002141)2.99766419
38Congenital primary aphakia (HP:0007707)2.99397688
39True hermaphroditism (HP:0010459)2.98713373
40Gaze-evoked nystagmus (HP:0000640)2.90205199
41Male infertility (HP:0003251)2.90028229
42Increased neuronal autofluorescent lipopigment (HP:0002074)2.88550905
43Abnormal spermatogenesis (HP:0008669)2.85829826
44Clumsiness (HP:0002312)2.85226054
45Urinary bladder sphincter dysfunction (HP:0002839)2.76509031
46Potter facies (HP:0002009)2.75660402
47Facial shape deformation (HP:0011334)2.75660402
48Postural instability (HP:0002172)2.73627572
49Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.67185439
50Chorioretinal atrophy (HP:0000533)2.65455090
51Tubulointerstitial nephritis (HP:0001970)2.63851677
52Prostate neoplasm (HP:0100787)2.63802230
53Nephrogenic diabetes insipidus (HP:0009806)2.59129182
54Ketoacidosis (HP:0001993)2.58886023
55Azoospermia (HP:0000027)2.58244294
56Molar tooth sign on MRI (HP:0002419)2.55964702
57Abnormality of midbrain morphology (HP:0002418)2.55964702
58Abnormal protein glycosylation (HP:0012346)2.52091411
59Abnormal glycosylation (HP:0012345)2.52091411
60Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.52091411
61Abnormal protein N-linked glycosylation (HP:0012347)2.52091411
62Gonadotropin excess (HP:0000837)2.51997849
63Congenital stationary night blindness (HP:0007642)2.49728051
64Recurrent bronchitis (HP:0002837)2.49691776
65Portal hypertension (HP:0001409)2.46149867
66Chronic sinusitis (HP:0011109)2.45985486
67Progressive inability to walk (HP:0002505)2.42840180
68Hypoplastic iliac wings (HP:0002866)2.42292024
69Inability to walk (HP:0002540)2.41587223
70Congenital sensorineural hearing impairment (HP:0008527)2.38336120
71Retinitis pigmentosa (HP:0000510)2.37060635
72Amyotrophic lateral sclerosis (HP:0007354)2.35562769
73Abnormality of DNA repair (HP:0003254)2.35392921
74Fibular hypoplasia (HP:0003038)2.34054303
75Abnormality of alanine metabolism (HP:0010916)2.30934910
76Hyperalaninemia (HP:0003348)2.30934910
77Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.30934910
78Tubular atrophy (HP:0000092)2.30793424
79Difficulty walking (HP:0002355)2.29684767
80Keratoconus (HP:0000563)2.28508294
81Increased corneal curvature (HP:0100692)2.28508294
82Occipital encephalocele (HP:0002085)2.27478675
83Poor coordination (HP:0002370)2.27308129
84Male pseudohermaphroditism (HP:0000037)2.25583212
85Ulnar claw (HP:0001178)2.24477673
86Parakeratosis (HP:0001036)2.24397496
87Increased cerebral lipofuscin (HP:0011813)2.23178291
88Tubulointerstitial abnormality (HP:0001969)2.17552756
89Horizontal nystagmus (HP:0000666)2.16233049
90Tongue fasciculations (HP:0001308)2.14886954
91Genital tract atresia (HP:0001827)2.14316440
92Vaginal atresia (HP:0000148)2.14164623
93Abolished electroretinogram (ERG) (HP:0000550)2.13830171
94Impulsivity (HP:0100710)2.13226467
95Macular degeneration (HP:0000608)2.10622324
96Rectal prolapse (HP:0002035)2.10069419
97Sclerocornea (HP:0000647)2.09450577
98Attenuation of retinal blood vessels (HP:0007843)2.02933370
99Postaxial foot polydactyly (HP:0001830)2.02332703
100Large for gestational age (HP:0001520)2.01759614
101Muscle fibrillation (HP:0010546)2.01361079
102Bony spicule pigmentary retinopathy (HP:0007737)2.00490169
103Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.7967409
104Dynein arm defect of respiratory motile cilia (HP:0012255)12.1977541
105Absent/shortened dynein arms (HP:0200106)12.1977541
106Furrowed tongue (HP:0000221)1.99789758
107Hypoplasia of the capital femoral epiphysis (HP:0003090)1.96418403
108Microglossia (HP:0000171)1.96182100
109Supernumerary spleens (HP:0009799)1.94833726
110Hyperkalemia (HP:0002153)1.93572519
111Ketosis (HP:0001946)1.92849153
112Impaired proprioception (HP:0010831)1.90785502
113Aplasia/Hypoplasia of the lens (HP:0008063)1.89832384
114Breast hypoplasia (HP:0003187)1.89098425
115Postaxial hand polydactyly (HP:0001162)1.88848580
116Congenital hepatic fibrosis (HP:0002612)1.85659930
117Patellar aplasia (HP:0006443)1.84359862
118Anencephaly (HP:0002323)1.83268028
119Stage 5 chronic kidney disease (HP:0003774)1.78970168
120Facial cleft (HP:0002006)1.78192312
121Impaired vibratory sensation (HP:0002495)1.78042707
122Aplasia/Hypoplasia of the patella (HP:0006498)1.77150967
123Fair hair (HP:0002286)1.77013974
124Hyperventilation (HP:0002883)1.76550249
125Postnatal microcephaly (HP:0005484)1.76008281
126Decreased circulating renin level (HP:0003351)1.75994309
127Type I transferrin isoform profile (HP:0003642)1.75855575
128Renal dysplasia (HP:0000110)1.75677683
129Upper motor neuron abnormality (HP:0002127)1.74461105
130Abnormality of ocular smooth pursuit (HP:0000617)1.73813209
131Short ribs (HP:0000773)1.73196401
132Protruding tongue (HP:0010808)1.73159049
133Abnormality of saccadic eye movements (HP:0000570)1.71319028
134Tubulointerstitial fibrosis (HP:0005576)1.67678848
135Absent frontal sinuses (HP:0002688)1.67472970
136Abnormality of the renal cortex (HP:0011035)1.64158506
13711 pairs of ribs (HP:0000878)1.60779571
138Abnormality of permanent molar morphology (HP:0011071)1.60019637
139Abnormality of the dental root (HP:0006486)1.60019637
140Taurodontia (HP:0000679)1.60019637
141Oculomotor apraxia (HP:0000657)1.57802785
142Aplasia/Hypoplasia of the tongue (HP:0010295)1.55681513
143Papillary thyroid carcinoma (HP:0002895)1.54442277
144Heterotopia (HP:0002282)1.54424414
145Absent epiphyses (HP:0010577)1.53818273
146Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.53818273
147Cerebellar dysplasia (HP:0007033)1.52979156
148Breast carcinoma (HP:0003002)1.52668409
149Limb ataxia (HP:0002070)1.52329454
150Abnormality of molar (HP:0011077)1.50771781
151Abnormality of molar morphology (HP:0011070)1.50771781
152Abnormality of the anterior horn cell (HP:0006802)1.49741850
153Degeneration of anterior horn cells (HP:0002398)1.49741850
154Pancreatic fibrosis (HP:0100732)1.49530545
155Spastic tetraparesis (HP:0001285)1.48323232
156Abnormal drinking behavior (HP:0030082)1.48138329
157Polydipsia (HP:0001959)1.48138329
158Aplasia/Hypoplasia of the fibula (HP:0006492)1.47949947
159J-shaped sella turcica (HP:0002680)1.47440089
160Abnormality of the dental pulp (HP:0006479)1.46421779
161Median cleft lip (HP:0000161)1.44856828
162Abnormality of dentin (HP:0010299)1.43904052
163Dental crowding (HP:0000678)1.43521971
164Abnormality of renal excretion (HP:0011036)1.37858650
165Broad foot (HP:0001769)1.37727631
166Renovascular hypertension (HP:0100817)1.34665883
167Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.33571464
168Conjunctival telangiectasia (HP:0000524)1.32523693
169Cystic liver disease (HP:0006706)1.29599306
170Impaired smooth pursuit (HP:0007772)1.29038824
171Chronic otitis media (HP:0000389)1.26894725
172Easy fatigability (HP:0003388)1.25396366
173Pachygyria (HP:0001302)1.24485886
174Astigmatism (HP:0000483)1.23681856
175Type II lissencephaly (HP:0007260)1.23312062
176Hypoplasia of dental enamel (HP:0006297)1.21515986

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK39.40422156
2PDK49.40422156
3PDK26.07783600
4CDK195.59425170
5FRK4.61398711
6INSRR4.27293748
7TESK13.48864738
8LATS23.37552980
9ACVR1B3.29262651
10PRKD32.72708574
11ICK2.45507522
12STK392.44866429
13WNK42.44320758
14OXSR12.37398989
15PTK2B2.27129256
16PNCK2.11450717
17ZAK1.98025523
18NEK21.75833582
19TAF11.71196880
20ADRBK21.52590179
21MAP2K21.42090102
22PLK41.42044837
23MET1.36632059
24CDK121.30881500
25LMTK21.26894328
26STK381.22615766
27TGFBR11.21757556
28MELK1.18587491
29CCNB11.06765831
30CDC71.00494148
31WEE10.98140850
32TYRO30.97729069
33ADRBK10.97431268
34TNK20.95826710
35WNK10.95433053
36GRK10.95318456
37STK30.92333260
38IRAK10.87274397
39PDK10.86344816
40CAMKK20.86327393
41CHEK20.85062717
42TTK0.84379685
43PRKAA20.80029792
44MAPK150.79731779
45PIK3CG0.77144072
46PASK0.72359956
47MAP3K20.70594001
48NEK90.69135990
49BMX0.67456594
50MAP2K10.67209605
51MKNK20.66291481
52TXK0.65669573
53DYRK1B0.65639765
54BRSK20.64576209
55TAOK30.64375544
56TESK20.64141088
57STK38L0.61314838
58DAPK20.61030617
59CHEK10.60610975
60NTRK30.59044439
61MST1R0.57857084
62ATR0.51143277
63CHUK0.49327087
64RPS6KB20.46699527
65GRK70.44319644
66RIPK10.43664090
67MAPKAPK30.42713757
68MAP3K70.42560839
69KSR20.42313792
70PLK10.41706267
71DYRK30.40404925
72ATM0.40102459
73CAMK1G0.38818894
74MAPK130.37649402
75NUAK10.33972784
76CAMK2A0.32491842
77PINK10.31857423
78FGR0.31730926
79MUSK0.31509574
80MAP2K60.30946104
81CASK0.29792540
82BRAF0.28514876
83PDPK10.27073320
84YES10.27049113
85TLK10.25743673
86FER0.25721081
87RET0.24115184
88NTRK20.22563824
89PLK20.22106502
90MTOR0.21429580
91PKN10.21322181
92JAK20.20361137
93PAK10.20325036
94ITK0.20187970
95BMPR1B0.20141555
96MAP3K40.19934459
97BRSK10.18963704
98MARK30.18695803
99DDR20.17920594
100MAP2K70.17507139
101EEF2K0.17283999
102PRKAA10.17072927
103PDGFRB0.16618912
104NEK60.16301808
105PRKCE0.16212132
106PRKCG0.16167190
107PRKACA0.15388453
108CAMK10.14095770
109MARK10.13558771
110CAMKK10.12748222
111CSNK1D0.12592903
112RPS6KA60.12154055
113EGFR0.12083848
114TIE10.11655281
115MAPK110.11460722
116IRAK20.11244767
117PRKG20.11226919
118BUB10.11201985
119PRKG10.10875291
120STK100.10695400
121PIM10.10160796
122MAPK10.09653031
123PAK20.09625006
124ZAP700.09027426
125LATS10.08771895
126AKT30.08374961
127CDK10.08193433
128PRKCI0.08122524
129CSNK2A10.08085102
130MKNK10.08078187
131PRKD10.07920323
132CSNK2A20.07828110
133MAPKAPK50.07702808
134CDK20.07521699
135RPS6KB10.07287576
136PRKCQ0.07253743
137PRKDC0.07097729
138MAPK30.07011499
139IGF1R0.06926104
140WNK30.06824591
141RIPK40.05961174
142PRKACG0.05954833
143ERN10.05637364
144NLK0.05448261
145TEC0.05238838
146AKT10.04446080
147CDK30.04302998
148GSK3B0.03713855
149CDK150.03145459
150STK110.02443683
151PRKACB0.02240542
152CDK70.02124228
153CDK40.01181927
154MAPK80.00679574
155PBK0.00634034
156CDK180.00514987
157MARK20.00075752
158AURKB-0.0150682
159CSF1R-0.0137438
160PRKCA-0.0132911
161CDK11A-0.0068640
162PRKCB-0.0060164
163AURKA-0.0004636

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.89065286
2Pyruvate metabolism_Homo sapiens_hsa006204.34089300
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.87249077
4Propanoate metabolism_Homo sapiens_hsa006403.77053823
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.67044483
6Basal transcription factors_Homo sapiens_hsa030223.49489487
7Pentose phosphate pathway_Homo sapiens_hsa000303.40719841
8Primary bile acid biosynthesis_Homo sapiens_hsa001203.28977245
9Phototransduction_Homo sapiens_hsa047443.23356588
10Selenocompound metabolism_Homo sapiens_hsa004502.99499902
11Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.97456562
12Fanconi anemia pathway_Homo sapiens_hsa034602.78526900
13Fatty acid biosynthesis_Homo sapiens_hsa000612.75540397
14Glucagon signaling pathway_Homo sapiens_hsa049222.65254588
15Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.60174803
16Butanoate metabolism_Homo sapiens_hsa006502.54785489
17Nicotine addiction_Homo sapiens_hsa050332.54309074
18Tryptophan metabolism_Homo sapiens_hsa003802.51245225
19Huntingtons disease_Homo sapiens_hsa050162.33878744
20Oocyte meiosis_Homo sapiens_hsa041142.25019663
21Dorso-ventral axis formation_Homo sapiens_hsa043202.24399781
22Glycosaminoglycan degradation_Homo sapiens_hsa005312.20373587
23Maturity onset diabetes of the young_Homo sapiens_hsa049502.15942344
24alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.02928664
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.02558112
26Glycerolipid metabolism_Homo sapiens_hsa005611.95594252
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.94481758
28Linoleic acid metabolism_Homo sapiens_hsa005911.92053740
29Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.83817805
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.71536615
31Olfactory transduction_Homo sapiens_hsa047401.71011237
32Sphingolipid metabolism_Homo sapiens_hsa006001.69999277
33Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.66550846
34PPAR signaling pathway_Homo sapiens_hsa033201.65437048
35Carbon metabolism_Homo sapiens_hsa012001.64508704
36Caffeine metabolism_Homo sapiens_hsa002321.59664182
37Histidine metabolism_Homo sapiens_hsa003401.58437030
38Phenylalanine metabolism_Homo sapiens_hsa003601.57670941
39Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.39730438
40Morphine addiction_Homo sapiens_hsa050321.37493503
41RNA transport_Homo sapiens_hsa030131.37433546
42Vitamin digestion and absorption_Homo sapiens_hsa049771.36375118
43Nitrogen metabolism_Homo sapiens_hsa009101.35483393
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.33095904
45Amphetamine addiction_Homo sapiens_hsa050311.31576215
46Cardiac muscle contraction_Homo sapiens_hsa042601.26518360
47Carbohydrate digestion and absorption_Homo sapiens_hsa049731.24252701
48Biosynthesis of amino acids_Homo sapiens_hsa012301.24093701
49Renin secretion_Homo sapiens_hsa049241.19927929
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.19293055
51mRNA surveillance pathway_Homo sapiens_hsa030151.16404470
52Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.16133965
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.15242600
54Glutamatergic synapse_Homo sapiens_hsa047241.12350619
55Serotonergic synapse_Homo sapiens_hsa047261.05996239
56Homologous recombination_Homo sapiens_hsa034401.05668273
57Purine metabolism_Homo sapiens_hsa002301.03574052
58Fructose and mannose metabolism_Homo sapiens_hsa000511.02803265
59Glycerophospholipid metabolism_Homo sapiens_hsa005641.02388715
60Mineral absorption_Homo sapiens_hsa049780.95490864
61Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.94868423
62Renin-angiotensin system_Homo sapiens_hsa046140.92462080
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.90109217
64Salivary secretion_Homo sapiens_hsa049700.87781820
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.85830863
66Fatty acid metabolism_Homo sapiens_hsa012120.84284502
67Ether lipid metabolism_Homo sapiens_hsa005650.84001312
68Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.83508892
69beta-Alanine metabolism_Homo sapiens_hsa004100.83058932
70Fat digestion and absorption_Homo sapiens_hsa049750.82514938
71Tyrosine metabolism_Homo sapiens_hsa003500.82356662
72Antigen processing and presentation_Homo sapiens_hsa046120.82088506
73ABC transporters_Homo sapiens_hsa020100.81582338
74Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.80126471
75Fatty acid degradation_Homo sapiens_hsa000710.79688628
76Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.77857299
77Glutathione metabolism_Homo sapiens_hsa004800.75665795
78Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.75660875
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.72659829
80Long-term potentiation_Homo sapiens_hsa047200.69800200
81GABAergic synapse_Homo sapiens_hsa047270.65367522
82Vascular smooth muscle contraction_Homo sapiens_hsa042700.64577592
83Chemical carcinogenesis_Homo sapiens_hsa052040.63880534
84Long-term depression_Homo sapiens_hsa047300.60236154
85Systemic lupus erythematosus_Homo sapiens_hsa053220.59858990
86Estrogen signaling pathway_Homo sapiens_hsa049150.58066465
87Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57493377
88Calcium signaling pathway_Homo sapiens_hsa040200.57237737
89Cyanoamino acid metabolism_Homo sapiens_hsa004600.56949624
90Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56934018
91Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56077864
92Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.54406328
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52856273
94Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52598843
95Cell cycle_Homo sapiens_hsa041100.51351383
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47747493
97Inositol phosphate metabolism_Homo sapiens_hsa005620.47050620
98Collecting duct acid secretion_Homo sapiens_hsa049660.44650676
99Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.43969091
100cGMP-PKG signaling pathway_Homo sapiens_hsa040220.43829823
101* Metabolic pathways_Homo sapiens_hsa011000.42711423
102Intestinal immune network for IgA production_Homo sapiens_hsa046720.42478553
103Lysine degradation_Homo sapiens_hsa003100.41603896
104Drug metabolism - other enzymes_Homo sapiens_hsa009830.41511091
105Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41375757
106Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.41209213
107Bile secretion_Homo sapiens_hsa049760.38635727
108Taste transduction_Homo sapiens_hsa047420.37372450
109Synaptic vesicle cycle_Homo sapiens_hsa047210.36245655
110Sphingolipid signaling pathway_Homo sapiens_hsa040710.36009527
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.35949508
112Insulin secretion_Homo sapiens_hsa049110.35672536
113African trypanosomiasis_Homo sapiens_hsa051430.34571473
114Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.33550301
115Melanoma_Homo sapiens_hsa052180.32637658
116VEGF signaling pathway_Homo sapiens_hsa043700.32571469
117RNA degradation_Homo sapiens_hsa030180.32240536
118Thyroid hormone synthesis_Homo sapiens_hsa049180.31699350
119Protein digestion and absorption_Homo sapiens_hsa049740.31240278
120Starch and sucrose metabolism_Homo sapiens_hsa005000.30761450
121Cholinergic synapse_Homo sapiens_hsa047250.30480999
122Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.30213272
123RNA polymerase_Homo sapiens_hsa030200.29675414
124Adipocytokine signaling pathway_Homo sapiens_hsa049200.29048461
125Arachidonic acid metabolism_Homo sapiens_hsa005900.28632010
126Legionellosis_Homo sapiens_hsa051340.28366055
127One carbon pool by folate_Homo sapiens_hsa006700.27858924
128* N-Glycan biosynthesis_Homo sapiens_hsa005100.26675133
129Steroid hormone biosynthesis_Homo sapiens_hsa001400.25217812
130Arginine and proline metabolism_Homo sapiens_hsa003300.25177273
131Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.24966104
132AMPK signaling pathway_Homo sapiens_hsa041520.24341511
133Retinol metabolism_Homo sapiens_hsa008300.23769674
134Oxytocin signaling pathway_Homo sapiens_hsa049210.23522710
135Pyrimidine metabolism_Homo sapiens_hsa002400.23252018
136Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.23131786
137Sulfur relay system_Homo sapiens_hsa041220.22440040
138Endocytosis_Homo sapiens_hsa041440.21048856
139Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.20702181
140Viral carcinogenesis_Homo sapiens_hsa052030.20473174
141Hedgehog signaling pathway_Homo sapiens_hsa043400.20411451
142Pentose and glucuronate interconversions_Homo sapiens_hsa000400.20185414
143Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.18238213
144Basal cell carcinoma_Homo sapiens_hsa052170.17630040
145Circadian entrainment_Homo sapiens_hsa047130.17628535
146Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.16756324
147MAPK signaling pathway_Homo sapiens_hsa040100.15900991
148Pancreatic secretion_Homo sapiens_hsa049720.15749128
149p53 signaling pathway_Homo sapiens_hsa041150.14365343
150Gastric acid secretion_Homo sapiens_hsa049710.14126911
151cAMP signaling pathway_Homo sapiens_hsa040240.13669390
152Wnt signaling pathway_Homo sapiens_hsa043100.11864994
153Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.10944008
154Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.10418513
155Thyroid hormone signaling pathway_Homo sapiens_hsa049190.10071723
156Ovarian steroidogenesis_Homo sapiens_hsa049130.09775262

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