MFSD8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a ubiquitous integral membrane protein that contains a transporter domain and a major facilitator superfamily (MFS) domain. Other members of the major facilitator superfamily transport small solutes through chemiosmotic ion gradients. The substrate transported by this protein is unknown. The protein likely localizes to lysosomal membranes. Mutations in this gene are correlated with a variant form of late infantile-onset neuronal ceroid lipofuscinoses (vLINCL). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)5.83607827
2central nervous system myelination (GO:0022010)5.83607827
3L-amino acid import (GO:0043092)4.97174392
4neural tube formation (GO:0001841)4.62862880
5DNA double-strand break processing (GO:0000729)4.43647511
6fatty acid elongation (GO:0030497)4.20152662
7neuron cell-cell adhesion (GO:0007158)4.16362264
8presynaptic membrane assembly (GO:0097105)3.90584380
9protein localization to cilium (GO:0061512)3.90241709
10negative regulation of protein localization to cell surface (GO:2000009)3.83184439
11amino acid import (GO:0043090)3.77835087
12presynaptic membrane organization (GO:0097090)3.70531521
13respiratory chain complex IV assembly (GO:0008535)3.70239712
14replication fork processing (GO:0031297)3.64877944
15negative regulation of neurotransmitter transport (GO:0051589)3.57128385
16prenylation (GO:0097354)3.51415562
17protein prenylation (GO:0018342)3.51415562
18cell wall macromolecule catabolic process (GO:0016998)3.48885479
19cilium morphogenesis (GO:0060271)3.48236905
20protein neddylation (GO:0045116)3.46681691
21protein-cofactor linkage (GO:0018065)3.45108571
22photoreceptor cell maintenance (GO:0045494)3.44524633
23negative regulation of synaptic transmission, GABAergic (GO:0032229)3.41961581
24protein complex biogenesis (GO:0070271)3.41105250
25regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.36316364
26mitochondrial respiratory chain complex I assembly (GO:0032981)3.35677043
27NADH dehydrogenase complex assembly (GO:0010257)3.35677043
28mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.35677043
29mitochondrial respiratory chain complex assembly (GO:0033108)3.35113022
30cullin deneddylation (GO:0010388)3.34950079
31long-chain fatty acid biosynthetic process (GO:0042759)3.32402178
32epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.31232525
33cytochrome complex assembly (GO:0017004)3.30946201
34intraciliary transport (GO:0042073)3.30762288
35eye photoreceptor cell differentiation (GO:0001754)3.26750342
36photoreceptor cell differentiation (GO:0046530)3.26750342
37mitochondrial DNA replication (GO:0006264)3.24862485
38oligodendrocyte differentiation (GO:0048709)3.24280911
39RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.23853282
40regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.23218930
41myelination (GO:0042552)3.22962912
42L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.22344791
43platelet dense granule organization (GO:0060155)3.21335277
44negative regulation of neurotransmitter secretion (GO:0046929)3.18915287
45DNA catabolic process, exonucleolytic (GO:0000738)3.16601966
46cyclic nucleotide catabolic process (GO:0009214)3.14633094
47cerebral cortex radially oriented cell migration (GO:0021799)3.14088611
48glycine transport (GO:0015816)3.12365967
49regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.11948158
50regulation of mitotic spindle checkpoint (GO:1903504)3.11948158
51ensheathment of neurons (GO:0007272)3.11693582
52axon ensheathment (GO:0008366)3.11693582
53DNA integration (GO:0015074)3.11685729
54protein K11-linked deubiquitination (GO:0035871)3.03208938
55protein deneddylation (GO:0000338)3.02173739
56regulation of acyl-CoA biosynthetic process (GO:0050812)3.01364651
57proteasome assembly (GO:0043248)3.00032178
58recombinational repair (GO:0000725)2.99492501
59positive regulation of oligodendrocyte differentiation (GO:0048714)2.98733738
60cAMP catabolic process (GO:0006198)2.97863854
61double-strand break repair via homologous recombination (GO:0000724)2.96777527
62S-adenosylmethionine metabolic process (GO:0046500)2.95434841
63ubiquinone biosynthetic process (GO:0006744)2.95225106
64ubiquinone metabolic process (GO:0006743)2.93678788
65regulation of meiosis I (GO:0060631)2.93414385
66C-terminal protein lipidation (GO:0006501)2.91363483
67somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.91201492
68somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.91201492
69isotype switching (GO:0045190)2.91201492
70cilium organization (GO:0044782)2.89629583
71L-methionine salvage (GO:0071267)2.89580093
72L-methionine biosynthetic process (GO:0071265)2.89580093
73amino acid salvage (GO:0043102)2.89580093
74response to pheromone (GO:0019236)2.86775465
75long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.86450319
76cilium assembly (GO:0042384)2.85978031
77import into cell (GO:0098657)2.85879784
78C-terminal protein amino acid modification (GO:0018410)2.85773155
79mannosylation (GO:0097502)2.83879474
80glutamate receptor signaling pathway (GO:0007215)2.83815555
81long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.83324661
82negative regulation of DNA recombination (GO:0045910)2.81579197
83exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.81536346
84response to epinephrine (GO:0071871)2.81196432
85fatty-acyl-CoA metabolic process (GO:0035337)2.80416755
86ionotropic glutamate receptor signaling pathway (GO:0035235)2.80343794
87nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.79632216
88neurotransmitter-gated ion channel clustering (GO:0072578)2.77626118
89regulation of helicase activity (GO:0051095)2.77219264
90single strand break repair (GO:0000012)2.77202429
91detection of light stimulus involved in sensory perception (GO:0050962)2.76279164
92detection of light stimulus involved in visual perception (GO:0050908)2.76279164
93cellular response to epinephrine stimulus (GO:0071872)2.75271533
94peptidyl-histidine modification (GO:0018202)2.74700881
95pyrimidine nucleobase catabolic process (GO:0006208)2.73503774
96rRNA catabolic process (GO:0016075)2.72937541
97glycosphingolipid biosynthetic process (GO:0006688)2.72323755
98fatty-acyl-CoA biosynthetic process (GO:0046949)2.72279071
99tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.71915794
100RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.71915794
101histone mRNA catabolic process (GO:0071044)2.71421182
102cell wall macromolecule metabolic process (GO:0044036)2.71189920
103neuron remodeling (GO:0016322)2.70828477
104negative regulation of DNA-dependent DNA replication (GO:2000104)2.70513810
105epithelial cilium movement (GO:0003351)2.70019851
106regulation of sulfur metabolic process (GO:0042762)2.69567813
107transmission of nerve impulse (GO:0019226)2.69217720
108axoneme assembly (GO:0035082)2.67847140
109water-soluble vitamin biosynthetic process (GO:0042364)2.65628180
110regulation of glucokinase activity (GO:0033131)2.64608464
111regulation of hexokinase activity (GO:1903299)2.64608464
112G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.64427814
113detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.62831897
114retinal cone cell development (GO:0046549)2.62728776
115glycerophospholipid catabolic process (GO:0046475)2.62433746
116methionine biosynthetic process (GO:0009086)2.62221709
117mechanosensory behavior (GO:0007638)2.60343337
118histone H2A acetylation (GO:0043968)2.59358537
119very long-chain fatty acid metabolic process (GO:0000038)2.59144963
120adenosine metabolic process (GO:0046085)2.58164229
121nucleobase catabolic process (GO:0046113)2.57325955
122detection of calcium ion (GO:0005513)2.57280593
123C4-dicarboxylate transport (GO:0015740)2.56837208
124positive regulation of action potential (GO:0045760)2.56687480
125maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.56317311
126fucose catabolic process (GO:0019317)2.56235640
127L-fucose metabolic process (GO:0042354)2.56235640
128L-fucose catabolic process (GO:0042355)2.56235640
129regulation of cilium movement (GO:0003352)2.55291348
130negative regulation of synaptic transmission (GO:0050805)2.55004152
131regulation of collateral sprouting (GO:0048670)2.53967991
132piRNA metabolic process (GO:0034587)2.53964778
133quinone biosynthetic process (GO:1901663)2.52664832
134erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.52546779
135L-phenylalanine catabolic process (GO:0006559)2.52546779
136inositol phosphate catabolic process (GO:0071545)2.51548335
137nucleotide transmembrane transport (GO:1901679)2.51168263
138nonmotile primary cilium assembly (GO:0035058)2.50717657
139histone mRNA metabolic process (GO:0008334)2.48880045
140neuron-neuron synaptic transmission (GO:0007270)2.48425611
141regulation of voltage-gated calcium channel activity (GO:1901385)2.48296326
142centriole replication (GO:0007099)2.47813725
143righting reflex (GO:0060013)2.47735703
144estrogen biosynthetic process (GO:0006703)2.47502370
145thioester biosynthetic process (GO:0035384)2.47451584
146acyl-CoA biosynthetic process (GO:0071616)2.47451584
147regulation of cofactor metabolic process (GO:0051193)2.46635432
148regulation of coenzyme metabolic process (GO:0051196)2.46635432
149indolalkylamine metabolic process (GO:0006586)2.46040248
150DNA deamination (GO:0045006)2.43920674
151reflex (GO:0060004)2.43555101
152limb bud formation (GO:0060174)2.42366404
153gamma-aminobutyric acid transport (GO:0015812)2.40301509
154startle response (GO:0001964)2.40285454
155regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.40196789
156response to redox state (GO:0051775)2.39678643
157adult walking behavior (GO:0007628)2.39650418
158response to methylmercury (GO:0051597)2.38694507
159neuron recognition (GO:0008038)2.37842649
160opsonization (GO:0008228)2.37272368
161gamma-aminobutyric acid signaling pathway (GO:0007214)2.37264354
162GPI anchor metabolic process (GO:0006505)2.35940749
163establishment of mitochondrion localization (GO:0051654)2.35351379
164response to lipoprotein particle (GO:0055094)2.34760807
165activated T cell proliferation (GO:0050798)2.33900359
166L-serine transport (GO:0015825)2.32998591
167regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.32201613
168vocalization behavior (GO:0071625)2.32046109
169synaptic transmission, glutamatergic (GO:0035249)2.31590627
170glycolipid biosynthetic process (GO:0009247)2.31431921
171preassembly of GPI anchor in ER membrane (GO:0016254)2.31381834
172regulation of synaptic transmission, glutamatergic (GO:0051966)2.30739002
173neurotransmitter uptake (GO:0001504)2.30582785
174positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.29402923
175GPI anchor biosynthetic process (GO:0006506)2.29252590
176membrane tubulation (GO:0097320)2.27660031
177postsynaptic membrane organization (GO:0001941)2.26257907
178long-term synaptic potentiation (GO:0060291)2.26174718
179negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.25132797
180positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.24626105
181response to monoamine (GO:0071867)2.23887194
182response to catecholamine (GO:0071869)2.23887194
183auditory behavior (GO:0031223)2.21362266
184biotin metabolic process (GO:0006768)2.20748928
185coenzyme catabolic process (GO:0009109)2.20725478
186negative regulation of myoblast differentiation (GO:0045662)2.20174061
187ER overload response (GO:0006983)2.19686589
188regulation of memory T cell differentiation (GO:0043380)2.17648558
189neuronal action potential propagation (GO:0019227)2.17637408
190membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.15508865
191cellular response to catecholamine stimulus (GO:0071870)2.15385968
192cellular response to monoamine stimulus (GO:0071868)2.15385968
193protein localization to synapse (GO:0035418)2.14996286
194response to dietary excess (GO:0002021)2.14243982

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.20019047
2ZNF274_21170338_ChIP-Seq_K562_Hela3.25647967
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.23748324
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.81687653
5TAF15_26573619_Chip-Seq_HEK293_Human2.60443360
6EZH2_22144423_ChIP-Seq_EOC_Human2.58167775
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.51685428
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.50054916
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.39520600
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.38833671
11SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.13961718
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.13147253
13ELK1_19687146_ChIP-ChIP_HELA_Human2.11178996
14CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.04918997
15PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.01516619
16P300_19829295_ChIP-Seq_ESCs_Human2.00953863
17SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.00012645
18EST1_17652178_ChIP-ChIP_JURKAT_Human1.98473415
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.91200243
20ER_23166858_ChIP-Seq_MCF-7_Human1.90005505
21SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.89745599
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.87243671
23PIAS1_25552417_ChIP-Seq_VCAP_Human1.85982037
24JARID2_20064375_ChIP-Seq_MESCs_Mouse1.85173149
25OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.84323994
26RBPJ_22232070_ChIP-Seq_NCS_Mouse1.83420440
27SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.82698410
28SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.81428181
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.80972842
30EED_16625203_ChIP-ChIP_MESCs_Mouse1.78765993
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.78346276
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.77065829
33VDR_23849224_ChIP-Seq_CD4+_Human1.72661772
34SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.68401315
35AR_21572438_ChIP-Seq_LNCaP_Human1.67744765
36E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.67579609
37SMAD4_21799915_ChIP-Seq_A2780_Human1.67308614
38FUS_26573619_Chip-Seq_HEK293_Human1.66022935
39NANOG_18555785_Chip-Seq_ESCs_Mouse1.61248096
40EZH2_27304074_Chip-Seq_ESCs_Mouse1.61162585
41IGF1R_20145208_ChIP-Seq_DFB_Human1.60516724
42RNF2_18974828_ChIP-Seq_MESCs_Mouse1.60113157
43EZH2_18974828_ChIP-Seq_MESCs_Mouse1.60113157
44GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.60112004
45WT1_19549856_ChIP-ChIP_CCG9911_Human1.59756557
46MTF2_20144788_ChIP-Seq_MESCs_Mouse1.59256968
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.59197154
48ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.57739917
49TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.57700015
50PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56829168
51SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.56567959
52EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.55175323
53AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.51583231
54SUZ12_27294783_Chip-Seq_NPCs_Mouse1.51575298
55VDR_22108803_ChIP-Seq_LS180_Human1.51519919
56PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.49595426
57JARID2_20075857_ChIP-Seq_MESCs_Mouse1.48595329
58PADI4_21655091_ChIP-ChIP_MCF-7_Human1.48229627
59IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45655298
60CBP_20019798_ChIP-Seq_JUKART_Human1.45655298
61P53_22387025_ChIP-Seq_ESCs_Mouse1.44678362
62VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.44613793
63GATA1_22025678_ChIP-Seq_K562_Human1.44592655
64EZH2_27294783_Chip-Seq_ESCs_Mouse1.43903571
65PCGF2_27294783_Chip-Seq_ESCs_Mouse1.42019604
66CBX2_27304074_Chip-Seq_ESCs_Mouse1.41214488
67E2F1_18555785_Chip-Seq_ESCs_Mouse1.40980355
68HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.40945893
69CMYC_18555785_Chip-Seq_ESCs_Mouse1.40116263
70FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.40091302
71SUZ12_18555785_Chip-Seq_ESCs_Mouse1.39748568
72STAT3_23295773_ChIP-Seq_U87_Human1.38329840
73UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.37382806
74FLI1_27457419_Chip-Seq_LIVER_Mouse1.37208124
75EZH2_27294783_Chip-Seq_NPCs_Mouse1.34650313
76MYC_18940864_ChIP-ChIP_HL60_Human1.34605268
77SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34343422
78SUZ12_27294783_Chip-Seq_ESCs_Mouse1.33847541
79CDX2_19796622_ChIP-Seq_MESCs_Mouse1.32659420
80RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.31888776
81AR_25329375_ChIP-Seq_VCAP_Human1.31425575
82NFE2_27457419_Chip-Seq_LIVER_Mouse1.31153183
83EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.31043657
84SMAD_19615063_ChIP-ChIP_OVARY_Human1.31035979
85PCGF2_27294783_Chip-Seq_NPCs_Mouse1.30992473
86MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.30501587
87TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30099740
88FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.29124869
89MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.28823643
90BP1_19119308_ChIP-ChIP_Hs578T_Human1.28767252
91NR3C1_21868756_ChIP-Seq_MCF10A_Human1.28702423
92* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.28551079
93STAT3_18555785_Chip-Seq_ESCs_Mouse1.28144907
94TCF4_23295773_ChIP-Seq_U87_Human1.28031304
95P300_18555785_Chip-Seq_ESCs_Mouse1.26741083
96RUNX1_27457419_Chip-Seq_LIVER_Mouse1.24915502
97TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.24749516
98SRF_21415370_ChIP-Seq_HL-1_Mouse1.24426412
99KLF5_20875108_ChIP-Seq_MESCs_Mouse1.23945578
100RNF2_27304074_Chip-Seq_ESCs_Mouse1.23874386
101RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.22962011
102TP53_18474530_ChIP-ChIP_U2OS_Human1.22679262
103TAL1_26923725_Chip-Seq_HPCs_Mouse1.22270604
104DROSHA_22980978_ChIP-Seq_HELA_Human1.21997799
105FOXP3_21729870_ChIP-Seq_TREG_Human1.21833906
106CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.20579994
107BCAT_22108803_ChIP-Seq_LS180_Human1.19739248
108BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.19258961
109SOX2_18555785_Chip-Seq_ESCs_Mouse1.19027108
110CDX2_22108803_ChIP-Seq_LS180_Human1.19022111
111NANOG_19829295_ChIP-Seq_ESCs_Human1.18591543
112SOX2_19829295_ChIP-Seq_ESCs_Human1.18591543
113EWS_26573619_Chip-Seq_HEK293_Human1.18491871
114TCF4_22108803_ChIP-Seq_LS180_Human1.17181546
115CRX_20693478_ChIP-Seq_RETINA_Mouse1.16914974
116RUNX2_22187159_ChIP-Seq_PCA_Human1.16446430
117TP53_22573176_ChIP-Seq_HFKS_Human1.16438211
118NMYC_18555785_Chip-Seq_ESCs_Mouse1.16323546
119PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.15610165
120GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.15437334
121REST_21632747_ChIP-Seq_MESCs_Mouse1.15399517
122KDM2B_26808549_Chip-Seq_REH_Human1.12652189
123CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.12572078
124E2F4_17652178_ChIP-ChIP_JURKAT_Human1.11807557
125PU1_27457419_Chip-Seq_LIVER_Mouse1.11304970
126NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.10860758
127NRF2_20460467_ChIP-Seq_MEFs_Mouse1.10860758
128FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.10397085
129NOTCH1_21737748_ChIP-Seq_TLL_Human1.10102812
130PRDM14_20953172_ChIP-Seq_ESCs_Human1.09709246
131OCT4_18555785_Chip-Seq_ESCs_Mouse1.09684070
132ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08313984
133IRF1_19129219_ChIP-ChIP_H3396_Human1.08083398
134BMI1_23680149_ChIP-Seq_NPCS_Mouse1.07886250
135SMAD1_18555785_Chip-Seq_ESCs_Mouse1.07574729
136CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.06782281
137FOXA1_21572438_ChIP-Seq_LNCaP_Human1.06226703
138HTT_18923047_ChIP-ChIP_STHdh_Human1.03847695
139TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02574378
140SALL4_22934838_ChIP-ChIP_CD34+_Human1.02476760
141FOXM1_26456572_ChIP-Seq_MCF-7_Human1.01504848
142KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.99363493
143AR_20517297_ChIP-Seq_VCAP_Human0.99117194
144FLI1_21867929_ChIP-Seq_TH2_Mouse0.98826014

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.82682476
2MP0003880_abnormal_central_pattern3.52809054
3MP0003787_abnormal_imprinting3.34761962
4MP0000920_abnormal_myelination2.90840273
5MP0001486_abnormal_startle_reflex2.65996481
6MP0005646_abnormal_pituitary_gland2.65428334
7MP0004147_increased_porphyrin_level2.55876285
8MP0003950_abnormal_plasma_membrane2.50582171
9MP0003690_abnormal_glial_cell2.43692273
10MP0004859_abnormal_synaptic_plasticity2.41248527
11MP0008995_early_reproductive_senescence2.39514306
12MP0001529_abnormal_vocalization2.38776813
13MP0004270_analgesia2.31530442
14MP0008058_abnormal_DNA_repair2.29485371
15MP0006054_spinal_hemorrhage2.25708904
16MP0001501_abnormal_sleep_pattern2.24600647
17MP0005171_absent_coat_pigmentation2.24104824
18MP0004742_abnormal_vestibular_system2.23556440
19MP0009745_abnormal_behavioral_response2.22090576
20MP0003635_abnormal_synaptic_transmissio2.16909428
21MP0002272_abnormal_nervous_system2.16108993
22MP0003121_genomic_imprinting2.12904309
23MP0005551_abnormal_eye_electrophysiolog2.12609570
24MP0003786_premature_aging2.04870154
25MP0002876_abnormal_thyroid_physiology2.04454935
26MP0002064_seizures2.03956214
27MP0005645_abnormal_hypothalamus_physiol1.98720759
28MP0003195_calcinosis1.94284091
29MP0000427_abnormal_hair_cycle1.93904002
30MP0004142_abnormal_muscle_tone1.86230012
31MP0000778_abnormal_nervous_system1.86055405
32MP0005365_abnormal_bile_salt1.84793125
33MP0002572_abnormal_emotion/affect_behav1.82912276
34MP0008057_abnormal_DNA_replication1.80322657
35MP0002063_abnormal_learning/memory/cond1.73882584
36MP0001764_abnormal_homeostasis1.73194994
37MP0001502_abnormal_circadian_rhythm1.72189840
38MP0009046_muscle_twitch1.70786974
39MP0001188_hyperpigmentation1.70153529
40MP0002736_abnormal_nociception_after1.69298696
41MP0003890_abnormal_embryonic-extraembry1.68844213
42MP0002102_abnormal_ear_morphology1.65900655
43MP0003718_maternal_effect1.65364845
44MP0002138_abnormal_hepatobiliary_system1.62356278
45MP0006035_abnormal_mitochondrial_morpho1.62341806
46MP0005409_darkened_coat_color1.61800813
47MP0002837_dystrophic_cardiac_calcinosis1.59575136
48MP0001968_abnormal_touch/_nociception1.59520029
49MP0000372_irregular_coat_pigmentation1.57768713
50MP0004885_abnormal_endolymph1.57309243
51MP0002751_abnormal_autonomic_nervous1.56527707
52MP0002067_abnormal_sensory_capabilities1.55649110
53MP0004130_abnormal_muscle_cell1.51994358
54MP0001905_abnormal_dopamine_level1.50968472
55MP0008789_abnormal_olfactory_epithelium1.47843244
56MP0001440_abnormal_grooming_behavior1.47299541
57MP0002139_abnormal_hepatobiliary_system1.46008943
58MP0000566_synostosis1.44031281
59MP0002229_neurodegeneration1.42464825
60MP0003329_amyloid_beta_deposits1.38585024
61MP0000516_abnormal_urinary_system1.37643194
62MP0005367_renal/urinary_system_phenotyp1.37643194
63MP0003724_increased_susceptibility_to1.37501489
64MP0000647_abnormal_sebaceous_gland1.37265308
65MP0003283_abnormal_digestive_organ1.36502045
66MP0004924_abnormal_behavior1.34706840
67MP0005386_behavior/neurological_phenoty1.34706840
68MP0003122_maternal_imprinting1.34702177
69MP0004381_abnormal_hair_follicle1.32182476
70MP0003656_abnormal_erythrocyte_physiolo1.31244386
71MP0005084_abnormal_gallbladder_morpholo1.29181175
72MP0005360_urolithiasis1.28404197
73MP0001293_anophthalmia1.27667895
74MP0001485_abnormal_pinna_reflex1.27474978
75MP0003634_abnormal_glial_cell1.26466974
76MP0010386_abnormal_urinary_bladder1.23721108
77MP0006036_abnormal_mitochondrial_physio1.21821545
78MP0004043_abnormal_pH_regulation1.18180065
79MP0003136_yellow_coat_color1.15282851
80MP0006276_abnormal_autonomic_nervous1.15083193
81MP0001963_abnormal_hearing_physiology1.14773083
82MP0003567_abnormal_fetal_cardiomyocyte1.14433711
83MP0008875_abnormal_xenobiotic_pharmacok1.12973101
84MP0001984_abnormal_olfaction1.11589409
85MP0003183_abnormal_peptide_metabolism1.11396375
86MP0005085_abnormal_gallbladder_physiolo1.10727250
87MP0000383_abnormal_hair_follicle1.09563781
88MP0002734_abnormal_mechanical_nocicepti1.09443062
89MP0006292_abnormal_olfactory_placode1.08722832
90MP0005535_abnormal_body_temperature1.08546704
91MP0005423_abnormal_somatic_nervous1.07509601
92MP0004215_abnormal_myocardial_fiber1.06761896
93MP0002557_abnormal_social/conspecific_i1.06583055
94MP0002638_abnormal_pupillary_reflex1.06467586
95MP0009780_abnormal_chondrocyte_physiolo1.06452924
96MP0010094_abnormal_chromosome_stability1.06209756
97MP0003937_abnormal_limbs/digits/tail_de1.04373514
98MP0008007_abnormal_cellular_replicative1.03445587
99MP0001661_extended_life_span1.00505575
100MP0005253_abnormal_eye_physiology0.99772658
101MP0008874_decreased_physiological_sensi0.98865952
102MP0002118_abnormal_lipid_homeostasis0.98519955
103MP0001324_abnormal_eye_pigmentation0.97482997
104MP0004484_altered_response_of0.97452438
105MP0002882_abnormal_neuron_morphology0.97395808
106MP0003633_abnormal_nervous_system0.96711527
107MP0001970_abnormal_pain_threshold0.96020050
108MP0005379_endocrine/exocrine_gland_phen0.95639423
109MP0000569_abnormal_digit_pigmentation0.94853010
110MP0010329_abnormal_lipoprotein_level0.94825171
111MP0002733_abnormal_thermal_nociception0.94370116
112MP0002066_abnormal_motor_capabilities/c0.92900346
113MP0005195_abnormal_posterior_eye0.92869385
114MP0002254_reproductive_system_inflammat0.92388721
115MP0002928_abnormal_bile_duct0.92207289
116MP0004134_abnormal_chest_morphology0.91242482
117MP0005332_abnormal_amino_acid0.90824652
118MP0009764_decreased_sensitivity_to0.90819537
119MP0001986_abnormal_taste_sensitivity0.89873135
120MP0010678_abnormal_skin_adnexa0.88636561
121MP0000026_abnormal_inner_ear0.87967019
122MP0002938_white_spotting0.87352305
123MP0009697_abnormal_copulation0.87225984
124MP0003631_nervous_system_phenotype0.85152307
125MP0008260_abnormal_autophagy0.84431778
126MP0005391_vision/eye_phenotype0.83968955
127MP0000604_amyloidosis0.83947672
128MP0005499_abnormal_olfactory_system0.82813989
129MP0005394_taste/olfaction_phenotype0.82813989
130MP0005075_abnormal_melanosome_morpholog0.82634378
131MP0008775_abnormal_heart_ventricle0.81157047
132MP0008569_lethality_at_weaning0.81066678
133MP0002090_abnormal_vision0.81063132
134MP0003186_abnormal_redox_activity0.80890185
135MP0003011_delayed_dark_adaptation0.80369848
136MP0002282_abnormal_trachea_morphology0.80294885
137MP0008872_abnormal_physiological_respon0.80291471
138MP0002752_abnormal_somatic_nervous0.80150334
139MP0002735_abnormal_chemical_nociception0.80034164
140MP0000631_abnormal_neuroendocrine_gland0.79803042
141MP0003191_abnormal_cellular_cholesterol0.79592821
142MP0006072_abnormal_retinal_apoptosis0.79436386
143MP0005451_abnormal_body_composition0.78601974
144MP0003806_abnormal_nucleotide_metabolis0.78370123
145MP0003252_abnormal_bile_duct0.77433272
146MP0003938_abnormal_ear_development0.77273889
147MP0009765_abnormal_xenobiotic_induced0.77160050
148MP0000955_abnormal_spinal_cord0.76480339
149MP0002184_abnormal_innervation0.75130628
150MP0001929_abnormal_gametogenesis0.74967761
151MP0002233_abnormal_nose_morphology0.74845717
152MP0005310_abnormal_salivary_gland0.73200455
153MP0005389_reproductive_system_phenotype0.72504521
154MP0003221_abnormal_cardiomyocyte_apopto0.71717750
155MP0001835_abnormal_antigen_presentation0.71662575
156MP0003943_abnormal_hepatobiliary_system0.70478691
157MP0002009_preneoplasia0.69174552
158MP0001666_abnormal_nutrient_absorption0.68195812
159MP0003137_abnormal_impulse_conducting0.67138560
160MP0000358_abnormal_cell_content/0.66966538
161MP0003172_abnormal_lysosome_physiology0.66292575

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic fibrosis (HP:0100732)4.11862983
2Pancreatic cysts (HP:0001737)4.07889325
3Degeneration of the lateral corticospinal tracts (HP:0002314)3.86664568
4Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.86664568
5True hermaphroditism (HP:0010459)3.83337091
6Hyperventilation (HP:0002883)3.81082440
7Focal motor seizures (HP:0011153)3.66214180
8Neurofibrillary tangles (HP:0002185)3.59185929
9Abnormality of midbrain morphology (HP:0002418)3.58174403
10Molar tooth sign on MRI (HP:0002419)3.58174403
11Renal cortical cysts (HP:0000803)3.22163808
12Epileptic encephalopathy (HP:0200134)3.20529498
13Split foot (HP:0001839)3.19559686
14Abnormality of the renal cortex (HP:0011035)2.96570192
15Abnormality of the corticospinal tract (HP:0002492)2.96534952
16Nephronophthisis (HP:0000090)2.88889126
17Oligodactyly (hands) (HP:0001180)2.81740708
18Parakeratosis (HP:0001036)2.73721860
19Aplasia/Hypoplasia of the tongue (HP:0010295)2.73607537
20Aplasia/Hypoplasia of the tibia (HP:0005772)2.72481184
21Short tibia (HP:0005736)2.71594412
22Metaphyseal dysplasia (HP:0100255)2.69028317
23White forelock (HP:0002211)2.67320838
24Fair hair (HP:0002286)2.62248374
25Methylmalonic acidemia (HP:0002912)2.60356232
26Blue irides (HP:0000635)2.55046670
27Disproportionate short-trunk short stature (HP:0003521)2.54216480
28Prolonged partial thromboplastin time (HP:0003645)2.53716583
29Abnormality of the renal medulla (HP:0100957)2.53568184
30Patchy hypopigmentation of hair (HP:0011365)2.49754326
31Colon cancer (HP:0003003)2.48235756
32Excessive salivation (HP:0003781)2.47640487
33Drooling (HP:0002307)2.47640487
34Gaze-evoked nystagmus (HP:0000640)2.44816384
35Medial flaring of the eyebrow (HP:0010747)2.42487621
36Postaxial foot polydactyly (HP:0001830)2.38914070
37Atonic seizures (HP:0010819)2.38841733
38Increased CSF lactate (HP:0002490)2.38823123
39Thyroiditis (HP:0100646)2.38488269
40Cerebral inclusion bodies (HP:0100314)2.38348744
41Abnormality of macular pigmentation (HP:0008002)2.38157581
42Severe visual impairment (HP:0001141)2.36915752
43Gait imbalance (HP:0002141)2.36258544
44Truncal ataxia (HP:0002078)2.36233982
45Tubulointerstitial nephritis (HP:0001970)2.34513509
46Abnormality of chromosome stability (HP:0003220)2.34038276
47Scanning speech (HP:0002168)2.33885480
48Progressive inability to walk (HP:0002505)2.32317576
49Bifid tongue (HP:0010297)2.30559515
50Mitochondrial inheritance (HP:0001427)2.28308386
51Cystic liver disease (HP:0006706)2.28215054
52Thyroid-stimulating hormone excess (HP:0002925)2.27263127
53Abnormality of vitamin B metabolism (HP:0004340)2.26415315
54Retinal dysplasia (HP:0007973)2.25786821
55Poor coordination (HP:0002370)2.25377579
56Volvulus (HP:0002580)2.24824671
57Febrile seizures (HP:0002373)2.20403581
58Abnormality of B cell number (HP:0010975)2.19984718
59Congenital hepatic fibrosis (HP:0002612)2.19336760
60Hyperglycinemia (HP:0002154)2.18835392
61Broad-based gait (HP:0002136)2.17608097
62Dysmetria (HP:0001310)2.17490788
63Thickened helices (HP:0000391)2.15790196
64Congenital primary aphakia (HP:0007707)2.15454087
65Cupped ear (HP:0000378)2.15147092
66Abnormality of aromatic amino acid family metabolism (HP:0004338)2.14726782
67Chronic hepatic failure (HP:0100626)2.13886219
68Increased serum pyruvate (HP:0003542)2.13869222
69Abnormality of glycolysis (HP:0004366)2.13869222
70Postaxial hand polydactyly (HP:0001162)2.13644501
71Submucous cleft hard palate (HP:0000176)2.13529914
72Slow saccadic eye movements (HP:0000514)2.13118263
73Absent speech (HP:0001344)2.12564505
74Aplasia/Hypoplasia of the uvula (HP:0010293)2.08239927
75Nephrogenic diabetes insipidus (HP:0009806)2.07918926
76Protruding tongue (HP:0010808)2.07632912
77Median cleft lip (HP:0000161)2.06254273
78Abnormality of the vitamin B12 metabolism (HP:0004341)2.06032297
79Lipid accumulation in hepatocytes (HP:0006561)2.05827707
80Abnormality of salivation (HP:0100755)2.05118017
81Supernumerary spleens (HP:0009799)2.04653321
82Abnormality of secondary sexual hair (HP:0009888)2.04546399
83Abnormality of the axillary hair (HP:0100134)2.04546399
84Vaginal atresia (HP:0000148)2.04546048
85Increased hepatocellular lipid droplets (HP:0006565)2.04368529
86Spastic gait (HP:0002064)2.04016870
87Hepatocellular necrosis (HP:0001404)2.02852542
88Widely spaced teeth (HP:0000687)2.02762586
89Anencephaly (HP:0002323)2.00993966
90Hyperlipoproteinemia (HP:0010980)2.00792173
91Acute necrotizing encephalopathy (HP:0006965)1.99863669
92Epileptiform EEG discharges (HP:0011182)1.98747469
93Focal seizures (HP:0007359)1.98421645
94Abolished electroretinogram (ERG) (HP:0000550)1.98354687
95Genital tract atresia (HP:0001827)1.97691572
96Hepatic necrosis (HP:0002605)1.96797991
97Generalized tonic-clonic seizures (HP:0002069)1.96640317
98Oculomotor apraxia (HP:0000657)1.96595971
99Bell-shaped thorax (HP:0001591)1.94812644
100Sclerocornea (HP:0000647)1.94483473
101Congenital sensorineural hearing impairment (HP:0008527)1.93895214
102Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.92073746
103Akinesia (HP:0002304)1.90951469
104Optic disc pallor (HP:0000543)1.90124561
105Stomach cancer (HP:0012126)1.89417457
106EEG with generalized epileptiform discharges (HP:0011198)1.89375989
107Alveolar cell carcinoma (HP:0006519)1.89097374
108Generalized hypopigmentation of hair (HP:0011358)1.88507402
109Male pseudohermaphroditism (HP:0000037)1.88239608
110Congenital stationary night blindness (HP:0007642)1.87636948
111Retinitis pigmentosa (HP:0000510)1.87093906
112Spastic paraparesis (HP:0002313)1.86857944
113Dialeptic seizures (HP:0011146)1.86546630
114Respiratory distress (HP:0002098)1.86400195
115Sensory axonal neuropathy (HP:0003390)1.86106678
1163-Methylglutaconic aciduria (HP:0003535)1.85637995
117Meckel diverticulum (HP:0002245)1.85285545
118Progressive macrocephaly (HP:0004481)1.84551140
119Abnormal biliary tract morphology (HP:0012440)1.84440570
120Poor eye contact (HP:0000817)1.83967210
121Intrahepatic cholestasis (HP:0001406)1.82846628
122Peripheral hypomyelination (HP:0007182)1.82757351
123Abnormality of glycine metabolism (HP:0010895)1.82061286
124Abnormality of serine family amino acid metabolism (HP:0010894)1.82061286
125Abnormality of aspartate family amino acid metabolism (HP:0010899)1.81917320
126Acute encephalopathy (HP:0006846)1.81829278
127Impaired vibratory sensation (HP:0002495)1.81716931
128Clumsiness (HP:0002312)1.81566097
129Abnormal biliary tract physiology (HP:0012439)1.81192396
130Bile duct proliferation (HP:0001408)1.81192396
131Small hand (HP:0200055)1.81149182
132Biliary tract neoplasm (HP:0100574)1.79671116
133Tubulointerstitial abnormality (HP:0001969)1.79668462
134Hypothermia (HP:0002045)1.78062026
135Ketosis (HP:0001946)1.77965935
136Anteriorly placed anus (HP:0001545)1.77325365
137B lymphocytopenia (HP:0010976)1.76766331
138Conjugated hyperbilirubinemia (HP:0002908)1.76755909
139Abnormality of the ileum (HP:0001549)1.76699015
140Stomatitis (HP:0010280)1.76507312
141Postural instability (HP:0002172)1.76051220
142Chromsome breakage (HP:0040012)1.75990524
143Furrowed tongue (HP:0000221)1.75422067
144Severe combined immunodeficiency (HP:0004430)1.75321363
145Decreased testicular size (HP:0008734)1.74532150
146Steatorrhea (HP:0002570)1.74477928
147Abnormality of the heme biosynthetic pathway (HP:0010472)1.74274769
148Methylmalonic aciduria (HP:0012120)1.74148739
149Sloping forehead (HP:0000340)1.73539366
150Preaxial hand polydactyly (HP:0001177)1.73367282
151Abnormality of urine glucose concentration (HP:0011016)1.72923620
152Glycosuria (HP:0003076)1.72923620
153Astigmatism (HP:0000483)1.72424963
154Hypsarrhythmia (HP:0002521)1.72416120
155Broad foot (HP:0001769)1.71470421
156Abnormal mitochondria in muscle tissue (HP:0008316)1.71146971
157Intention tremor (HP:0002080)1.70933543
158Inability to walk (HP:0002540)1.69387046
159Abnormality of the labia minora (HP:0012880)1.68281209
160Abnormality of serum amino acid levels (HP:0003112)1.68218581
161Increased circulating renin level (HP:0000848)1.68204681
162Dysdiadochokinesis (HP:0002075)1.68131139
163Alacrima (HP:0000522)1.67664959
164Prominent nasal bridge (HP:0000426)1.67453993
165Diplopia (HP:0000651)1.67138626
166Abnormality of binocular vision (HP:0011514)1.67138626
167CNS demyelination (HP:0007305)1.66032820
168Dyskinesia (HP:0100660)1.65694667
169Narrow forehead (HP:0000341)1.65624149
170Cerebral edema (HP:0002181)1.64038247
171Increased serum lactate (HP:0002151)1.63930372
172Hyperglycinuria (HP:0003108)1.63792422
173Abnormal rod and cone electroretinograms (HP:0008323)1.63459515
174Tubular atrophy (HP:0000092)1.63109358
175Intestinal atresia (HP:0011100)1.62161096
176Abnormality of methionine metabolism (HP:0010901)1.61347805

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK4.29294599
2CASK4.25540143
3FRK4.17431184
4STK393.14017977
5EIF2AK33.00348617
6EPHA42.72270651
7TRIM282.71536186
8MAP4K22.70260754
9INSRR2.63104946
10PRPF4B2.59987105
11NUAK12.48968310
12OXSR12.35232150
13MUSK2.28062220
14BMPR22.26660856
15CAMKK22.09627088
16BRSK22.08019026
17MST42.01441109
18EPHB12.00984726
19BMPR1B1.92059792
20SRPK11.88820890
21MAP2K71.78749781
22FGFR21.73449527
23NTRK31.71410622
24ACVR1B1.65151938
25MKNK21.58935332
26TAOK31.54159490
27BCR1.54061207
28MARK11.46377824
29SGK4941.41599027
30SGK2231.41599027
31STK161.40253278
32MKNK11.36575730
33NTRK21.33837397
34FES1.30520072
35RIPK41.29750382
36IRAK31.26278953
37STK38L1.25294413
38DAPK21.24633430
39PKN11.24617980
40PAK31.24001807
41PBK1.23534374
42PINK11.23524867
43RPS6KA41.17203586
44CAMK1D1.16363772
45MAP3K121.14067679
46MAP3K141.12500502
47PLK31.12330461
48NLK1.12309729
49MAP3K131.11918949
50CAMK1G1.07981210
51CSNK1G11.07447822
52PLK41.07382629
53ZAK1.07314698
54STK31.06711270
55CAMK2B1.06000047
56SGK21.01696217
57MAPKAPK51.01083451
58CDK31.00845163
59MAPK131.00387518
60MAP3K40.98231967
61CSNK1G20.97716886
62PRKCQ0.96835782
63EIF2AK10.96782426
64WNK10.95815652
65CDK190.95217205
66DYRK30.93533410
67CSNK1G30.92684145
68GRK70.92431776
69PRKCE0.91985271
70PLK20.91391965
71ADRBK20.89162058
72IRAK40.88306743
73PDK20.87789791
74CDK50.87354181
75CAMK2D0.85742217
76FGR0.83527840
77CAMK2A0.83443882
78SIK30.81681916
79MAP2K40.78925479
80NEK60.78893885
81WNK40.77639876
82BRD40.76634432
83PHKG20.75686510
84PHKG10.75686510
85MAPK70.75199950
86VRK10.73512739
87IRAK10.72082293
88MAPK150.69578862
89FLT30.69039188
90TGFBR10.68609654
91PRKCG0.68352088
92PIK3CA0.66385151
93TAOK20.64974522
94DYRK20.64481598
95MAPK120.63835990
96YES10.62920842
97LATS10.62855629
98NTRK10.62206093
99GRK10.61927505
100TAF10.61457285
101AKT30.61295961
102EIF2AK20.60947706
103DYRK1A0.60812876
104MAP3K60.60778724
105CAMK2G0.60617129
106ERBB30.60547131
107TNK20.60539610
108EPHA30.60486078
109TRPM70.60185863
110WNK30.59188259
111BCKDK0.58405818
112PRKG10.57326552
113JAK10.57262332
114ATM0.55791928
115PIK3CG0.53899006
116PRKAA20.53581608
117CSF1R0.52790586
118SGK10.52771038
119CSNK1A1L0.51750247
120MET0.50169370
121MAP2K60.49440061
122ARAF0.48232316
123OBSCN0.47484105
124TEC0.47248163
125STK240.46980112
126PRKACA0.46510598
127NEK10.45750143
128ERBB40.45053869
129CCNB10.44302352
130TXK0.42637091
131ITK0.42588323
132FGFR10.42223440
133PTK2B0.41275230
134ATR0.41222719
135PLK10.41184251
136IGF1R0.41136459
137SGK30.40970331
138SYK0.40519801
139ABL10.40351527
140MARK20.39916890
141IKBKE0.39909735
142KSR10.39285100
143MINK10.38797850
144PDPK10.38604807
145DAPK10.38269888
146EGFR0.36903360
147FER0.36028046
148BTK0.34190084
149CSNK1A10.33855973
150MAP3K20.30975915
151MAP3K50.30685303
152ADRBK10.29828236
153TSSK60.29121825
154BRSK10.28750390
155CDC70.28692315

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034503.05457171
2Fatty acid elongation_Homo sapiens_hsa000623.04848702
3Steroid biosynthesis_Homo sapiens_hsa001002.67530780
4Basal transcription factors_Homo sapiens_hsa030222.49726192
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.46608192
6Nicotine addiction_Homo sapiens_hsa050332.22793134
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.22419257
8Morphine addiction_Homo sapiens_hsa050322.13379744
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.13210646
10Proteasome_Homo sapiens_hsa030502.13164259
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.08625198
12Fanconi anemia pathway_Homo sapiens_hsa034602.03544997
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.92910541
14Glutamatergic synapse_Homo sapiens_hsa047241.90003781
15Histidine metabolism_Homo sapiens_hsa003401.88445395
16Phototransduction_Homo sapiens_hsa047441.87566848
17RNA polymerase_Homo sapiens_hsa030201.84441993
18Propanoate metabolism_Homo sapiens_hsa006401.84330015
19Homologous recombination_Homo sapiens_hsa034401.82668873
20Selenocompound metabolism_Homo sapiens_hsa004501.82620424
21Fatty acid biosynthesis_Homo sapiens_hsa000611.81949409
22GABAergic synapse_Homo sapiens_hsa047271.81605176
23Linoleic acid metabolism_Homo sapiens_hsa005911.80295265
24RNA degradation_Homo sapiens_hsa030181.75409279
25Fatty acid metabolism_Homo sapiens_hsa012121.70453974
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.69308383
27Circadian entrainment_Homo sapiens_hsa047131.62398029
28Serotonergic synapse_Homo sapiens_hsa047261.61799867
29Primary bile acid biosynthesis_Homo sapiens_hsa001201.60259511
30Ether lipid metabolism_Homo sapiens_hsa005651.60071298
31Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.55263020
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.54572750
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.54287957
34Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.44783865
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.44769219
36Mismatch repair_Homo sapiens_hsa034301.42591203
37Fatty acid degradation_Homo sapiens_hsa000711.41881369
38Peroxisome_Homo sapiens_hsa041461.40442008
39Sulfur metabolism_Homo sapiens_hsa009201.39030501
40Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.31738670
41Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.27143559
42PPAR signaling pathway_Homo sapiens_hsa033201.22660254
43Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.21351765
44Sphingolipid metabolism_Homo sapiens_hsa006001.18987349
45Parkinsons disease_Homo sapiens_hsa050121.18718607
46Butanoate metabolism_Homo sapiens_hsa006501.17764794
47One carbon pool by folate_Homo sapiens_hsa006701.17605068
48beta-Alanine metabolism_Homo sapiens_hsa004101.15740703
49Protein export_Homo sapiens_hsa030601.15016812
50Fat digestion and absorption_Homo sapiens_hsa049751.13498715
51Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.11890267
52Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.09863754
53Nucleotide excision repair_Homo sapiens_hsa034201.09708610
54Collecting duct acid secretion_Homo sapiens_hsa049661.08006969
55Dopaminergic synapse_Homo sapiens_hsa047281.07856689
56Cholinergic synapse_Homo sapiens_hsa047251.02168464
57ABC transporters_Homo sapiens_hsa020101.01291097
58Chemical carcinogenesis_Homo sapiens_hsa052041.01280690
59Olfactory transduction_Homo sapiens_hsa047400.98946861
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.98338902
61Calcium signaling pathway_Homo sapiens_hsa040200.97446867
62Nitrogen metabolism_Homo sapiens_hsa009100.95846534
63Amphetamine addiction_Homo sapiens_hsa050310.95406878
64Purine metabolism_Homo sapiens_hsa002300.95206735
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.94762503
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.94403804
67Glycerolipid metabolism_Homo sapiens_hsa005610.94111515
68Insulin secretion_Homo sapiens_hsa049110.93424857
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.92414782
70RNA transport_Homo sapiens_hsa030130.92188246
71Oxidative phosphorylation_Homo sapiens_hsa001900.91205463
72Taste transduction_Homo sapiens_hsa047420.90830859
73Rheumatoid arthritis_Homo sapiens_hsa053230.90494590
74Pyrimidine metabolism_Homo sapiens_hsa002400.89719947
75Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.89715113
76Axon guidance_Homo sapiens_hsa043600.89482123
77Pentose and glucuronate interconversions_Homo sapiens_hsa000400.87719930
78Complement and coagulation cascades_Homo sapiens_hsa046100.87025660
79Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.84944633
80Autoimmune thyroid disease_Homo sapiens_hsa053200.84204189
81Asthma_Homo sapiens_hsa053100.84178006
82Salivary secretion_Homo sapiens_hsa049700.83505823
83Cysteine and methionine metabolism_Homo sapiens_hsa002700.82475500
84Intestinal immune network for IgA production_Homo sapiens_hsa046720.80533377
85Type I diabetes mellitus_Homo sapiens_hsa049400.80289869
86Long-term depression_Homo sapiens_hsa047300.79812439
87Alzheimers disease_Homo sapiens_hsa050100.79767271
88Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77744710
89Huntingtons disease_Homo sapiens_hsa050160.77651602
90Cocaine addiction_Homo sapiens_hsa050300.77477570
91Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.77337884
92Renin secretion_Homo sapiens_hsa049240.76577851
93cAMP signaling pathway_Homo sapiens_hsa040240.76247419
94Long-term potentiation_Homo sapiens_hsa047200.75615136
95Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.72852688
96Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.72815515
97Retinol metabolism_Homo sapiens_hsa008300.71408376
98Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.71090547
99Tryptophan metabolism_Homo sapiens_hsa003800.70997229
100Vitamin digestion and absorption_Homo sapiens_hsa049770.66180687
101Caffeine metabolism_Homo sapiens_hsa002320.65681055
102Spliceosome_Homo sapiens_hsa030400.63744436
103Regulation of autophagy_Homo sapiens_hsa041400.63484952
104Drug metabolism - other enzymes_Homo sapiens_hsa009830.59816482
105Pyruvate metabolism_Homo sapiens_hsa006200.58321336
106Allograft rejection_Homo sapiens_hsa053300.58282984
107Staphylococcus aureus infection_Homo sapiens_hsa051500.58001111
108Folate biosynthesis_Homo sapiens_hsa007900.57755472
109Graft-versus-host disease_Homo sapiens_hsa053320.57576465
110Glutathione metabolism_Homo sapiens_hsa004800.56588324
111Arginine and proline metabolism_Homo sapiens_hsa003300.56061196
112Circadian rhythm_Homo sapiens_hsa047100.53543837
113Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53503750
114Primary immunodeficiency_Homo sapiens_hsa053400.50581841
115Dorso-ventral axis formation_Homo sapiens_hsa043200.50041815
116African trypanosomiasis_Homo sapiens_hsa051430.49574530
117Oxytocin signaling pathway_Homo sapiens_hsa049210.49424293
118Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.48405345
119Maturity onset diabetes of the young_Homo sapiens_hsa049500.48298433
120Vascular smooth muscle contraction_Homo sapiens_hsa042700.47640791
121Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44631890
122N-Glycan biosynthesis_Homo sapiens_hsa005100.43769985
123Sphingolipid signaling pathway_Homo sapiens_hsa040710.41620082
124Base excision repair_Homo sapiens_hsa034100.41127020
125Phosphatidylinositol signaling system_Homo sapiens_hsa040700.40450212
126Synaptic vesicle cycle_Homo sapiens_hsa047210.40190107
127Glycerophospholipid metabolism_Homo sapiens_hsa005640.39747035
128Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.39580234
129Prion diseases_Homo sapiens_hsa050200.39088493
130Ras signaling pathway_Homo sapiens_hsa040140.39082006
131Vibrio cholerae infection_Homo sapiens_hsa051100.37612138
132Type II diabetes mellitus_Homo sapiens_hsa049300.37250371
133cGMP-PKG signaling pathway_Homo sapiens_hsa040220.35139151
134Arachidonic acid metabolism_Homo sapiens_hsa005900.33812197
135Tyrosine metabolism_Homo sapiens_hsa003500.33162289
136Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.32961236
137Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.32608912
138Adipocytokine signaling pathway_Homo sapiens_hsa049200.32577084
139Metabolic pathways_Homo sapiens_hsa011000.32576769
140Mineral absorption_Homo sapiens_hsa049780.32415340
141Choline metabolism in cancer_Homo sapiens_hsa052310.30999012
142p53 signaling pathway_Homo sapiens_hsa041150.26000596
143RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.25831543

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