MFSD2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein neddylation (GO:0045116)7.40795762
2ribosomal small subunit assembly (GO:0000028)6.64948435
3protoporphyrinogen IX metabolic process (GO:0046501)6.35077118
4protoporphyrinogen IX biosynthetic process (GO:0006782)6.10764357
5heme biosynthetic process (GO:0006783)5.99334850
6pyrimidine deoxyribonucleotide catabolic process (GO:0009223)5.73088551
7oxygen transport (GO:0015671)5.47645252
8porphyrin-containing compound biosynthetic process (GO:0006779)5.24265059
9pyrimidine deoxyribonucleotide metabolic process (GO:0009219)5.20332208
10DNA deamination (GO:0045006)5.13496820
11viral transcription (GO:0019083)5.09659676
12erythrocyte maturation (GO:0043249)4.94755979
13translational termination (GO:0006415)4.89225316
14heme metabolic process (GO:0042168)4.80747742
15tetrapyrrole biosynthetic process (GO:0033014)4.77139339
16pyrimidine nucleotide catabolic process (GO:0006244)4.73158424
17telomere maintenance via semi-conservative replication (GO:0032201)4.59817721
18ATP synthesis coupled proton transport (GO:0015986)4.55263470
19energy coupled proton transport, down electrochemical gradient (GO:0015985)4.55263470
20gas transport (GO:0015669)4.52129038
21DNA strand elongation involved in DNA replication (GO:0006271)4.46832664
22translational elongation (GO:0006414)4.38377874
23ribosomal small subunit biogenesis (GO:0042274)4.38342965
24one-carbon compound transport (GO:0019755)4.35698278
25SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.34235779
26erythrocyte development (GO:0048821)4.31573667
27mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.28897048
28DNA strand elongation (GO:0022616)4.25272112
29autophagic vacuole fusion (GO:0000046)4.25091579
30cotranslational protein targeting to membrane (GO:0006613)4.23433808
31porphyrin-containing compound metabolic process (GO:0006778)4.22343994
32protein targeting to ER (GO:0045047)4.20863219
33DNA replication initiation (GO:0006270)4.14393759
34deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.09530991
35mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.05156049
36mitochondrial respiratory chain complex I assembly (GO:0032981)4.05156049
37NADH dehydrogenase complex assembly (GO:0010257)4.05156049
38regulation of erythrocyte differentiation (GO:0045646)4.05028880
39CENP-A containing nucleosome assembly (GO:0034080)4.04254965
40thrombin receptor signaling pathway (GO:0070493)4.02877363
41establishment of protein localization to endoplasmic reticulum (GO:0072599)4.01906101
42protein localization to endoplasmic reticulum (GO:0070972)3.98146771
43definitive hemopoiesis (GO:0060216)3.90854089
44nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.86194377
45mitochondrial calcium ion transport (GO:0006851)3.85339235
46telomere maintenance via recombination (GO:0000722)3.79484804
47embryonic hemopoiesis (GO:0035162)3.79271285
48cellular protein complex disassembly (GO:0043624)3.77895087
49neutrophil activation involved in immune response (GO:0002283)3.76132808
50chromatin remodeling at centromere (GO:0031055)3.75012448
51viral life cycle (GO:0019058)3.73838897
52translational initiation (GO:0006413)3.73779609
53protein complex biogenesis (GO:0070271)3.73463868
54establishment of protein localization to mitochondrial membrane (GO:0090151)3.69926244
55maturation of SSU-rRNA (GO:0030490)3.67128834
56deoxyribonucleotide catabolic process (GO:0009264)3.65274113
57positive regulation of erythrocyte differentiation (GO:0045648)3.60506016
58protein-cofactor linkage (GO:0018065)3.58924720
59DNA replication-independent nucleosome assembly (GO:0006336)3.54758911
60DNA replication-independent nucleosome organization (GO:0034724)3.54758911
61negative regulation of heart rate (GO:0010459)3.47441243
62mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.46231506
63DNA unwinding involved in DNA replication (GO:0006268)3.45493036
64mitochondrial respiratory chain complex assembly (GO:0033108)3.43181183
65mitotic recombination (GO:0006312)3.42975861
66electron transport chain (GO:0022900)3.42452491
67organelle membrane fusion (GO:0090174)3.41011596
68negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.40926875
69deoxyribose phosphate catabolic process (GO:0046386)3.40800920
70respiratory electron transport chain (GO:0022904)3.39072304
71chaperone-mediated protein transport (GO:0072321)3.36520662
72erythrocyte differentiation (GO:0030218)3.35445399
73protein complex disassembly (GO:0043241)3.34552378
74iron-sulfur cluster assembly (GO:0016226)3.33571490
75metallo-sulfur cluster assembly (GO:0031163)3.33571490
76proteasome assembly (GO:0043248)3.31431431
77telomere maintenance via telomere lengthening (GO:0010833)3.31321820
78kinetochore organization (GO:0051383)3.24713761
79kinetochore assembly (GO:0051382)3.22152070
80positive regulation of megakaryocyte differentiation (GO:0045654)3.20557243
81positive regulation of granulocyte differentiation (GO:0030854)3.19881895
82viral mRNA export from host cell nucleus (GO:0046784)3.19330202
83positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)3.16699851
84ribonucleoprotein complex biogenesis (GO:0022613)3.14842320
85macromolecular complex disassembly (GO:0032984)3.13745871
86nuclear-transcribed mRNA catabolic process (GO:0000956)3.12383738
87folic acid-containing compound biosynthetic process (GO:0009396)3.11869930
88pseudouridine synthesis (GO:0001522)3.09573642
89ribosomal large subunit biogenesis (GO:0042273)3.09298020
90myeloid cell development (GO:0061515)3.06800568
91antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.05330401
92antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.05330401
93positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.03681564
94translation (GO:0006412)3.03560114
95protein localization to chromosome, centromeric region (GO:0071459)3.03553417
96sequestering of actin monomers (GO:0042989)3.01851262
97formation of translation preinitiation complex (GO:0001731)3.01355461
98regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.00660597
99deoxyribose phosphate metabolic process (GO:0019692)3.00429597
100granulocyte differentiation (GO:0030851)3.00312531
1012-deoxyribonucleotide metabolic process (GO:0009394)2.99992134
102regulation of histone H3-K9 methylation (GO:0051570)2.99330796
103mRNA catabolic process (GO:0006402)2.98063556
104positive regulation of B cell differentiation (GO:0045579)2.97921426
105nucleotide-excision repair, DNA gap filling (GO:0006297)2.97709811
106DNA replication checkpoint (GO:0000076)2.97010465
107meiotic chromosome segregation (GO:0045132)2.95658990
108histone exchange (GO:0043486)2.95213903
109negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.92890349
110purine-containing compound salvage (GO:0043101)2.92468858
111negative regulation of appetite (GO:0032099)2.91852824
112negative regulation of response to food (GO:0032096)2.91852824
113preassembly of GPI anchor in ER membrane (GO:0016254)2.91527843
114RNA catabolic process (GO:0006401)2.91400621
115pigment biosynthetic process (GO:0046148)2.90538647
116tRNA methylation (GO:0030488)2.89462805
117negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.88753375
118protein localization to kinetochore (GO:0034501)2.87003730
119behavioral response to nicotine (GO:0035095)2.86128688
120attachment of spindle microtubules to kinetochore (GO:0008608)2.83997777
121tetrapyrrole metabolic process (GO:0033013)2.81819294
122RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.80008136
123tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.80008136
124rRNA processing (GO:0006364)2.79000228
125base-excision repair, AP site formation (GO:0006285)2.77984503
126ATP biosynthetic process (GO:0006754)2.77531384
127hydrogen peroxide catabolic process (GO:0042744)2.76739093
128translesion synthesis (GO:0019985)2.74843396
129activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.74829651
130protein targeting to membrane (GO:0006612)2.74483827
1312-deoxyribonucleotide biosynthetic process (GO:0009265)2.73327337
132deoxyribose phosphate biosynthetic process (GO:0046385)2.73327337
133polyamine biosynthetic process (GO:0006596)2.73289583
134cellular biogenic amine biosynthetic process (GO:0042401)2.73049792
135regulation of cilium movement (GO:0003352)2.72312418
136maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.72129406
137purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.70162832
138rRNA metabolic process (GO:0016072)2.70157754
139platelet dense granule organization (GO:0060155)2.68812803
140lipoxygenase pathway (GO:0019372)2.68367266
141negative regulation of erythrocyte differentiation (GO:0045647)2.68128156
142nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.67944428
143ribosome biogenesis (GO:0042254)2.67933653
144purine nucleoside triphosphate biosynthetic process (GO:0009145)2.67653966
145rRNA modification (GO:0000154)2.67203400
146DNA topological change (GO:0006265)2.67151865
147negative regulation of RNA splicing (GO:0033119)2.66706035
148protein targeting to mitochondrion (GO:0006626)2.65722795
149exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.64743366
150platelet aggregation (GO:0070527)2.64461992
151L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.64391384
152megakaryocyte development (GO:0035855)2.64203094
153negative regulation of thymocyte apoptotic process (GO:0070244)2.63126842
154mitochondrial calcium ion homeostasis (GO:0051560)2.62499425
155pteridine-containing compound biosynthetic process (GO:0042559)2.62006431
156blood coagulation, intrinsic pathway (GO:0007597)2.61808395
157histone mRNA metabolic process (GO:0008334)2.61238207
158amine biosynthetic process (GO:0009309)2.60019320
159hemoglobin metabolic process (GO:0020027)2.59251574
160GMP metabolic process (GO:0046037)2.57504286
161deoxyribonucleotide metabolic process (GO:0009262)2.56356479
162pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.56313852
163positive regulation of endothelial cell differentiation (GO:0045603)2.55694518
164purinergic nucleotide receptor signaling pathway (GO:0035590)2.55229632
165C-terminal protein lipidation (GO:0006501)2.53747674
166negative regulation of DNA-templated transcription, elongation (GO:0032785)2.53333278
167guanosine-containing compound biosynthetic process (GO:1901070)2.52759575
168regulation of integrin-mediated signaling pathway (GO:2001044)2.51254425
169dopamine transport (GO:0015872)2.51109264
170fatty acid elongation (GO:0030497)2.50414747
171GTP biosynthetic process (GO:0006183)2.46829084

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.05915906
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.54196554
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.53992216
4GATA1_22025678_ChIP-Seq_K562_Human3.35560483
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.30551825
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.16201853
7SCL_19346495_ChIP-Seq_HPC-7_Human3.05932400
8ELF1_17652178_ChIP-ChIP_JURKAT_Human2.92596483
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.80890447
10SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.80773620
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.65335295
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.60853166
13TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.59404651
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.53001907
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.52459647
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.51306305
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.44682812
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.35639271
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.33780422
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.33334613
21VDR_23849224_ChIP-Seq_CD4+_Human2.27388031
22MYC_19030024_ChIP-ChIP_MESCs_Mouse2.21587008
23FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.21254816
24MYC_19079543_ChIP-ChIP_MESCs_Mouse2.12822865
25* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.11830875
26CREB1_15753290_ChIP-ChIP_HEK293T_Human2.10254587
27HOXB4_20404135_ChIP-ChIP_EML_Mouse2.09251471
28TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.08951621
29SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.08382519
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.01215609
31GATA1_22383799_ChIP-Seq_G1ME_Mouse2.00510098
32XRN2_22483619_ChIP-Seq_HELA_Human2.00456815
33ERG_20887958_ChIP-Seq_HPC-7_Mouse1.98339298
34SRF_21415370_ChIP-Seq_HL-1_Mouse1.97725669
35FOXP3_21729870_ChIP-Seq_TREG_Human1.94994202
36RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.88999768
37GATA1_19941827_ChIP-Seq_MEL_Mouse1.88448391
38SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.88070752
39CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.83846221
40SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.78632607
41FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.78629314
42NELFA_20434984_ChIP-Seq_ESCs_Mouse1.76305689
43CIITA_25753668_ChIP-Seq_RAJI_Human1.76070920
44THAP11_20581084_ChIP-Seq_MESCs_Mouse1.75260980
45E2F1_18555785_ChIP-Seq_MESCs_Mouse1.73580088
46E2F1_21310950_ChIP-Seq_MCF-7_Human1.72252578
47DCP1A_22483619_ChIP-Seq_HELA_Human1.72080918
48SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.72011450
49GATA2_19941826_ChIP-Seq_K562_Human1.71029352
50GABP_19822575_ChIP-Seq_HepG2_Human1.70112763
51NOTCH1_21737748_ChIP-Seq_TLL_Human1.69560474
52MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.67985753
53PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59147354
54TTF2_22483619_ChIP-Seq_HELA_Human1.58109231
55MYC_22102868_ChIP-Seq_BL_Human1.56944739
56ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.55184542
57ELK1_19687146_ChIP-ChIP_HELA_Human1.53968759
58IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.52483924
59TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.52258361
60LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.52236353
61YY1_21170310_ChIP-Seq_MESCs_Mouse1.51574719
62VDR_21846776_ChIP-Seq_THP-1_Human1.50459483
63MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.47792260
64EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.47604239
65AR_21909140_ChIP-Seq_LNCAP_Human1.44812352
66MYB_21317192_ChIP-Seq_ERMYB_Mouse1.44269426
67NANOG_20526341_ChIP-Seq_ESCs_Human1.43254466
68VDR_22108803_ChIP-Seq_LS180_Human1.41547123
69SPI1_23547873_ChIP-Seq_NB4_Human1.41143638
70LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.40271932
71GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.40239350
72GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.39640458
73ZFX_18555785_ChIP-Seq_MESCs_Mouse1.39392846
74SRY_22984422_ChIP-ChIP_TESTIS_Rat1.37449440
75EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.37366504
76EGR1_19374776_ChIP-ChIP_THP-1_Human1.36716238
77BCL6_27268052_Chip-Seq_Bcells_Human1.36288570
78YY1_22570637_ChIP-Seq_MALME-3M_Human1.33389312
79HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.32567984
80MYCN_18555785_ChIP-Seq_MESCs_Mouse1.31753635
81GATA1_19941826_ChIP-Seq_K562_Human1.31704016
82GATA2_22383799_ChIP-Seq_G1ME_Mouse1.31575972
83RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.30350281
84TP53_22573176_ChIP-Seq_HFKS_Human1.30343659
85IRF8_22096565_ChIP-ChIP_GC-B_Human1.30165448
86NCOR1_26117541_ChIP-Seq_K562_Human1.25473241
87MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.23532103
88* RUNX1_22412390_ChIP-Seq_EML_Mouse1.23081496
89CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.22765756
90CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.20783076
91YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20210131
92ZNF274_21170338_ChIP-Seq_K562_Hela1.19756640
93E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.18771536
94ELF1_20517297_ChIP-Seq_JURKAT_Human1.18396377
95CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.17740568
96KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.17215640
97CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.15860900
98SPI1_20517297_ChIP-Seq_HL60_Human1.15116878
99GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14697642
100GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.14695925
101PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.14650616
102ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.13697111
103KDM5A_27292631_Chip-Seq_BREAST_Human1.11571856
104STAT4_19710469_ChIP-ChIP_TH1__Mouse1.11328967
105MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.11208896
106HTT_18923047_ChIP-ChIP_STHdh_Human1.09718359
107IRF1_19129219_ChIP-ChIP_H3396_Human1.09592840
108CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.09529401
109P300_27268052_Chip-Seq_Bcells_Human1.09406937
110* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.05535594
111GATA3_21878914_ChIP-Seq_MCF-7_Human1.05149264
112TFEB_21752829_ChIP-Seq_HELA_Human1.04800564
113NANOG_18555785_ChIP-Seq_MESCs_Mouse1.04075524
114BCOR_27268052_Chip-Seq_Bcells_Human1.03943350
115CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.03148448
116PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.01195917
117CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.00339892
118EWS_26573619_Chip-Seq_HEK293_Human0.99156750
119MYC_18940864_ChIP-ChIP_HL60_Human0.98704038
120* ETV2_25802403_ChIP-Seq_MESCs_Mouse0.98215975
121STAT1_20625510_ChIP-Seq_HELA_Human0.98127071
122VDR_24763502_ChIP-Seq_THP-1_Human0.97661481
123CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.97616796
124MYB_26560356_Chip-Seq_TH2_Human0.97325895
125* AR_20517297_ChIP-Seq_VCAP_Human0.96836674
126MYB_26560356_Chip-Seq_TH1_Human0.95090465
127TAF2_19829295_ChIP-Seq_ESCs_Human0.94555498
128POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.92746294
129MAF_26560356_Chip-Seq_TH1_Human0.91487431
130CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.90503111
131UTX_26944678_Chip-Seq_JUKART_Human0.87495598
132TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86613802
133PADI4_21655091_ChIP-ChIP_MCF-7_Human0.85692852
134FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84870687

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003656_abnormal_erythrocyte_physiolo6.80140956
2MP0004147_increased_porphyrin_level6.34602006
3MP0001545_abnormal_hematopoietic_system4.02055327
4MP0005397_hematopoietic_system_phenotyp4.02055327
5MP0002396_abnormal_hematopoietic_system3.88912095
6MP0005083_abnormal_biliary_tract3.59523030
7MP0003111_abnormal_nucleus_morphology3.20141239
8MP0003693_abnormal_embryo_hatching3.18721780
9MP0010094_abnormal_chromosome_stability3.04936290
10MP0008057_abnormal_DNA_replication2.97406415
11MP0006054_spinal_hemorrhage2.72603821
12MP0002132_abnormal_respiratory_system2.53952174
13MP0003077_abnormal_cell_cycle2.47158205
14MP0008058_abnormal_DNA_repair2.45401659
15MP0002653_abnormal_ependyma_morphology2.35536606
16MP0000490_abnormal_crypts_of2.28441979
17MP0004957_abnormal_blastocyst_morpholog2.23103331
18MP0005084_abnormal_gallbladder_morpholo2.21992806
19MP0008007_abnormal_cellular_replicative2.12369687
20MP0000372_irregular_coat_pigmentation1.96217428
21MP0005464_abnormal_platelet_physiology1.95976251
22MP0002398_abnormal_bone_marrow1.95337481
23MP0003724_increased_susceptibility_to1.94973328
24MP0001835_abnormal_antigen_presentation1.93746403
25MP0004808_abnormal_hematopoietic_stem1.93522392
26MP0003806_abnormal_nucleotide_metabolis1.90870970
27MP0005174_abnormal_tail_pigmentation1.90552507
28MP0005075_abnormal_melanosome_morpholog1.84299332
29MP0003186_abnormal_redox_activity1.83723396
30MP0006276_abnormal_autonomic_nervous1.79326185
31MP0009333_abnormal_splenocyte_physiolog1.77678337
32MP0004142_abnormal_muscle_tone1.74095706
33MP0005671_abnormal_response_to1.71205803
34MP0008004_abnormal_stomach_pH1.70580417
35MP0000465_gastrointestinal_hemorrhage1.69920163
36MP0002736_abnormal_nociception_after1.69802915
37MP0000689_abnormal_spleen_morphology1.63630063
38MP0002722_abnormal_immune_system1.58414505
39MP0003718_maternal_effect1.57654858
40MP0009379_abnormal_foot_pigmentation1.56694974
41MP0002429_abnormal_blood_cell1.49241499
42MP0006036_abnormal_mitochondrial_physio1.46772177
43MP0001853_heart_inflammation1.44108020
44MP0003763_abnormal_thymus_physiology1.44018315
45MP0005410_abnormal_fertilization1.40838441
46MP0005636_abnormal_mineral_homeostasis1.37725006
47MP0003878_abnormal_ear_physiology1.37387534
48MP0005377_hearing/vestibular/ear_phenot1.37387534
49MP0000230_abnormal_systemic_arterial1.35884193
50MP0002095_abnormal_skin_pigmentation1.34741712
51MP0006292_abnormal_olfactory_placode1.33526675
52MP0002166_altered_tumor_susceptibility1.30361230
53MP0003787_abnormal_imprinting1.29815568
54MP0000685_abnormal_immune_system1.29721757
55MP0000313_abnormal_cell_death1.27987702
56MP0002102_abnormal_ear_morphology1.27833989
57MP0001968_abnormal_touch/_nociception1.24436736
58MP0002019_abnormal_tumor_incidence1.23984819
59MP0001905_abnormal_dopamine_level1.23207230
60MP0000716_abnormal_immune_system1.22810332
61MP0001529_abnormal_vocalization1.21658226
62MP0003638_abnormal_response/metabolism_1.18427667
63MP0003011_delayed_dark_adaptation1.14987565
64MP0002420_abnormal_adaptive_immunity1.11708025
65MP0000703_abnormal_thymus_morphology1.11507600
66MP0003786_premature_aging1.10975953
67MP0002733_abnormal_thermal_nociception1.10224280
68MP0002006_tumorigenesis1.09960272
69MP0001819_abnormal_immune_cell1.09447287
70MP0005000_abnormal_immune_tolerance1.09028463
71MP0009785_altered_susceptibility_to1.08725265
72MP0001800_abnormal_humoral_immune1.07904679
73MP0005025_abnormal_response_to1.07103549
74MP0008932_abnormal_embryonic_tissue1.04085098
75MP0008995_early_reproductive_senescence1.03477774
76MP0000350_abnormal_cell_proliferation1.02542429
77MP0001663_abnormal_digestive_system1.02389062
78MP0002452_abnormal_antigen_presenting1.01507258
79MP0002723_abnormal_immune_serum1.00557345
80MP0009697_abnormal_copulation1.00257032
81MP0003436_decreased_susceptibility_to0.93970666
82MP0002405_respiratory_system_inflammati0.92866868
83MP0001764_abnormal_homeostasis0.90753906
84MP0009765_abnormal_xenobiotic_induced0.90110444
85MP0003136_yellow_coat_color0.89351631
86MP0002419_abnormal_innate_immunity0.88756328
87MP0004215_abnormal_myocardial_fiber0.88606045
88MP0008260_abnormal_autophagy0.88156172
89MP0002210_abnormal_sex_determination0.87757216
90MP0008872_abnormal_physiological_respon0.87591925
91MP0001293_anophthalmia0.87127381
92MP0005379_endocrine/exocrine_gland_phen0.86796909
93MP0002837_dystrophic_cardiac_calcinosis0.86663423
94MP0010155_abnormal_intestine_physiology0.86277019
95MP0003121_genomic_imprinting0.85883578
96MP0003879_abnormal_hair_cell0.84924817
97MP0001986_abnormal_taste_sensitivity0.83851058
98MP0008469_abnormal_protein_level0.83272738
99MP0005646_abnormal_pituitary_gland0.82225382
100MP0003122_maternal_imprinting0.81908842
101MP0001188_hyperpigmentation0.79680890
102MP0003123_paternal_imprinting0.79594622
103MP0003646_muscle_fatigue0.76691404
104MP0001929_abnormal_gametogenesis0.75514460
105MP0002877_abnormal_melanocyte_morpholog0.75160103
106MP0001970_abnormal_pain_threshold0.74922441
107MP0008775_abnormal_heart_ventricle0.74593844
108MP0008875_abnormal_xenobiotic_pharmacok0.73750869
109MP0005551_abnormal_eye_electrophysiolog0.73589649
110MP0008789_abnormal_olfactory_epithelium0.72912773
111MP0003698_abnormal_male_reproductive0.72825674
112MP0001915_intracranial_hemorrhage0.72820827
113MP0000343_altered_response_to0.72352249
114MP0000358_abnormal_cell_content/0.71922876
115MP0005167_abnormal_blood-brain_barrier0.70933073
116MP0008877_abnormal_DNA_methylation0.70796335
117MP0000015_abnormal_ear_pigmentation0.70767590
118MP0002638_abnormal_pupillary_reflex0.70294778
119MP0002080_prenatal_lethality0.69994461
120MP0001348_abnormal_lacrimal_gland0.68887451
121MP0002938_white_spotting0.68533977
122MP0009763_increased_sensitivity_to0.67298684
123MP0009278_abnormal_bone_marrow0.66677994
124MP0002089_abnormal_postnatal_growth/wei0.66431583
125MP0006035_abnormal_mitochondrial_morpho0.66165909
126MP0000653_abnormal_sex_gland0.64937188
127MP0002148_abnormal_hypersensitivity_rea0.64713147
128MP0003567_abnormal_fetal_cardiomyocyte0.63982609
129MP0003943_abnormal_hepatobiliary_system0.63530698
130MP0001919_abnormal_reproductive_system0.63521835
131MP0009764_decreased_sensitivity_to0.63212756
132MP0000858_altered_metastatic_potential0.63174512
133MP0010307_abnormal_tumor_latency0.61926712
134MP0004145_abnormal_muscle_electrophysio0.61343391
135MP0000631_abnormal_neuroendocrine_gland0.61224930
136MP0001845_abnormal_inflammatory_respons0.61068004
137MP0009642_abnormal_blood_homeostasis0.60781874
138MP0009931_abnormal_skin_appearance0.59929646
139MP0001145_abnormal_male_reproductive0.59614688
140MP0005584_abnormal_enzyme/coenzyme_acti0.59444477
141MP0001730_embryonic_growth_arrest0.59414123
142MP0003866_abnormal_defecation0.58611056
143MP0000598_abnormal_liver_morphology0.58367959
144MP0001873_stomach_inflammation0.57991040
145MP0008770_decreased_survivor_rate0.57956767
146MP0005394_taste/olfaction_phenotype0.56863086
147MP0005499_abnormal_olfactory_system0.56863086
148MP0002138_abnormal_hepatobiliary_system0.56544130

Predicted human phenotypes

RankGene SetZ-score
1Abnormal number of erythroid precursors (HP:0012131)7.78102158
2Abnormality of cells of the erythroid lineage (HP:0012130)7.38168014
3Petechiae (HP:0000967)6.22068829
4Poikilocytosis (HP:0004447)5.68241141
5Aplastic anemia (HP:0001915)5.65412131
6Acanthocytosis (HP:0001927)5.11474375
7Prolonged bleeding time (HP:0003010)5.10651422
8Pallor (HP:0000980)4.45089296
9Reticulocytopenia (HP:0001896)4.26807279
10Abnormality of reticulocytes (HP:0004312)4.24747761
11Reticulocytosis (HP:0001923)4.23589282
12Acute necrotizing encephalopathy (HP:0006965)4.07346471
13Chronic otitis media (HP:0000389)3.91627689
14Abnormal hemoglobin (HP:0011902)3.91506996
15Abnormal mitochondria in muscle tissue (HP:0008316)3.79794738
16Acute encephalopathy (HP:0006846)3.76115852
17Reduced antithrombin III activity (HP:0001976)3.74083912
18Increased serum ferritin (HP:0003281)3.68929667
19Type I transferrin isoform profile (HP:0003642)3.38831403
20Hyperbilirubinemia (HP:0002904)3.38132993
21Epistaxis (HP:0000421)3.31031427
22Progressive macrocephaly (HP:0004481)3.28578352
23Macrocytic anemia (HP:0001972)3.27958034
24Short middle phalanx of the 5th finger (HP:0004220)3.11454198
25Abnormality of iron homeostasis (HP:0011031)3.11431821
26Impaired platelet aggregation (HP:0003540)3.04963069
27Abnormal platelet function (HP:0011869)3.04963069
28Birth length less than 3rd percentile (HP:0003561)3.02044210
29Renal Fanconi syndrome (HP:0001994)2.96489649
30Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.82638470
31Abnormality of alanine metabolism (HP:0010916)2.82638470
32Hyperalaninemia (HP:0003348)2.82638470
33Purpura (HP:0000979)2.80373478
34Myelodysplasia (HP:0002863)2.76445149
35Abnormality of transition element cation homeostasis (HP:0011030)2.74001982
36Hyperthyroidism (HP:0000836)2.68669938
37Microcytic anemia (HP:0001935)2.66360266
38Abnormal protein glycosylation (HP:0012346)2.59859266
39Abnormal glycosylation (HP:0012345)2.59859266
40Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.59859266
41Abnormal protein N-linked glycosylation (HP:0012347)2.59859266
42Hyperlipoproteinemia (HP:0010980)2.50950689
43Cutaneous photosensitivity (HP:0000992)2.50513708
443-Methylglutaconic aciduria (HP:0003535)2.49472405
45Polycythemia (HP:0001901)2.49048747
46Oral leukoplakia (HP:0002745)2.48920941
47Abnormal platelet volume (HP:0011876)2.48177395
48IgM deficiency (HP:0002850)2.48113456
49Pancreatic fibrosis (HP:0100732)2.42052844
50Pancytopenia (HP:0001876)2.37555587
51Abnormal spermatogenesis (HP:0008669)2.37155352
52Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.36379887
53Decreased activity of mitochondrial respiratory chain (HP:0008972)2.36379887
54Cerebral edema (HP:0002181)2.33979522
55Ileus (HP:0002595)2.30938061
56Thrombocytosis (HP:0001894)2.30368161
5711 pairs of ribs (HP:0000878)2.28717327
58Chromsome breakage (HP:0040012)2.28221179
59Microvesicular hepatic steatosis (HP:0001414)2.26751053
60Increased hepatocellular lipid droplets (HP:0006565)2.24583413
61Pancreatic cysts (HP:0001737)2.24486173
62Increased mean platelet volume (HP:0011877)2.22944383
63Abnormal pupillary function (HP:0007686)2.21929146
64Nausea (HP:0002018)2.20854104
65Dyschromatopsia (HP:0007641)2.19951727
66Cerebral palsy (HP:0100021)2.18870917
67Decreased central vision (HP:0007663)2.18654312
68Exertional dyspnea (HP:0002875)2.16549023
69Hepatocellular necrosis (HP:0001404)2.15932532
70Abnormality of midbrain morphology (HP:0002418)2.15349084
71Molar tooth sign on MRI (HP:0002419)2.15349084
72Abnormality of renal resorption (HP:0011038)2.14278802
73Broad palm (HP:0001169)2.13152312
74Lipid accumulation in hepatocytes (HP:0006561)2.10963401
75Lactic acidosis (HP:0003128)2.10259138
76Azoospermia (HP:0000027)2.07402173
77Bone marrow hypocellularity (HP:0005528)2.05781785
78Increased serum lactate (HP:0002151)2.04906108
79Abnormality of the columella (HP:0009929)2.04618919
80Increased IgM level (HP:0003496)2.04200106
81Abnormal rod and cone electroretinograms (HP:0008323)2.03890404
82Recurrent viral infections (HP:0004429)2.03832438
83Chromosomal breakage induced by crosslinking agents (HP:0003221)2.03830138
84Increased intramyocellular lipid droplets (HP:0012240)2.03275315
85Optic disc pallor (HP:0000543)2.01238866
86Hypoplasia of the thymus (HP:0000778)2.00349540
87Aplasia/Hypoplasia of the sacrum (HP:0008517)2.00089132
88Abnormality of the heme biosynthetic pathway (HP:0010472)10.8935932
89Muscle fiber atrophy (HP:0100295)1.96550622
90Severe visual impairment (HP:0001141)1.96435204
91Diaphragmatic weakness (HP:0009113)1.95773037
92Abnormality of chromosome stability (HP:0003220)1.95306506
93Brushfield spots (HP:0001088)1.94842170
94True hermaphroditism (HP:0010459)1.94714520
95Hepatic necrosis (HP:0002605)1.94551478
96Abnormality of the preputium (HP:0100587)1.93102583
97Acute lymphatic leukemia (HP:0006721)1.92760947
98Neutropenia (HP:0001875)1.91704716
99Pendular nystagmus (HP:0012043)1.91009808
100Congenital stationary night blindness (HP:0007642)1.90723412
101Absent rod-and cone-mediated responses on ERG (HP:0007688)1.88561728
102Fatigue (HP:0012378)1.86237000
103Lymphoma (HP:0002665)1.84702555
104Small intestinal stenosis (HP:0012848)1.84482819
105Duodenal stenosis (HP:0100867)1.84482819
106Tongue fasciculations (HP:0001308)1.84340715
107Mitochondrial inheritance (HP:0001427)1.84063835
108Cholelithiasis (HP:0001081)1.83391902
109Generalized aminoaciduria (HP:0002909)1.83041136
110Increased muscle lipid content (HP:0009058)1.82576411
111Type 2 muscle fiber atrophy (HP:0003554)1.82197389
112Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.81760029
113Hypochromic anemia (HP:0001931)1.78831129
114Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.78225239
115Hypochromic microcytic anemia (HP:0004840)1.78180684
116Thyroid-stimulating hormone excess (HP:0002925)1.77904642
117Exercise intolerance (HP:0003546)1.77390092
118Stomatitis (HP:0010280)1.76410480
119Menorrhagia (HP:0000132)1.76310066
120Respiratory failure (HP:0002878)1.74360621
121Sclerocornea (HP:0000647)1.73688491
122Visual hallucinations (HP:0002367)1.73622247
123Pustule (HP:0200039)1.73547662
124Decreased electroretinogram (ERG) amplitude (HP:0000654)1.73132932
125Lethargy (HP:0001254)1.72971011
126Microretrognathia (HP:0000308)1.71678325
127Abnormal gallbladder morphology (HP:0012437)1.71462114
128Elevated erythrocyte sedimentation rate (HP:0003565)1.70993482
129Absent thumb (HP:0009777)1.70980675
130Panhypogammaglobulinemia (HP:0003139)1.70646189
131Patchy hypopigmentation of hair (HP:0011365)1.70023847
132Congenital, generalized hypertrichosis (HP:0004540)1.68497832
133Colon cancer (HP:0003003)1.68361666
134Abolished electroretinogram (ERG) (HP:0000550)1.68311926
135Abnormality of lateral ventricle (HP:0030047)1.67061054
136Tinnitus (HP:0000360)1.66875684
137Paralysis (HP:0003470)1.65903758
138Increased CSF lactate (HP:0002490)1.65767016
139Hypertensive crisis (HP:0100735)1.65427866
140Respiratory difficulties (HP:0002880)1.64874332
141Recurrent abscess formation (HP:0002722)1.64053846
142Agnosia (HP:0010524)1.63998735
143Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.63746895
144Migraine (HP:0002076)1.63745464
145Gingival bleeding (HP:0000225)1.62831510
146Acute myeloid leukemia (HP:0004808)1.62541057
147Progressive microcephaly (HP:0000253)1.62209622

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK164.72609633
2NME24.08221692
3VRK23.25720513
4MST43.23003224
5EIF2AK13.14045380
6PIM23.00413829
7NUAK12.66253160
8VRK12.61075963
9TNIK2.55222502
10CDK192.50049751
11WEE12.43206613
12CDC72.40086268
13DYRK32.38773245
14BUB12.37076971
15TESK22.13054314
16SCYL22.02330227
17BMX2.00682772
18EEF2K1.94778425
19TLK11.91616136
20NEK21.89262151
21KIT1.84588118
22CCNB11.80728683
23RIPK41.79352362
24ADRBK21.74897725
25BRSK21.70462013
26DYRK21.68389712
27TAOK31.68119590
28MAPKAPK51.67611148
29MAP4K11.64780802
30PTK2B1.63160722
31ZAK1.60246713
32GRK51.51610957
33RPS6KB21.51225881
34MATK1.42905424
35ACVR1B1.41928678
36BCKDK1.40535730
37ILK1.39556613
38MAP4K21.39413503
39PIM11.38131500
40BMPR1B1.37056006
41BTK1.35624540
42KDR1.30764687
43CDK71.30540036
44ATR1.28161957
45MYLK1.27719057
46TEC1.24251222
47STK41.22635844
48BRSK11.21303053
49TBK11.12532734
50MKNK11.11002865
51SRPK11.08565331
52NEK11.06603228
53TAF11.06454717
54TTK1.05661039
55PLK11.04395029
56PASK1.03933605
57MAP3K111.03848124
58MUSK1.03068621
59AURKB1.01775833
60CDK41.01569665
61GRK11.00571957
62MAP2K30.97707445
63WNK30.97478665
64PLK20.97243124
65TSSK60.96451532
66STK100.92937230
67MAP3K60.91340902
68TYK20.91154809
69ADRBK10.90737817
70MAPKAPK30.90006566
71IKBKB0.89786049
72RAF10.88363495
73PAK10.87669071
74BRAF0.87580245
75WNK40.87522688
76JAK30.86916988
77MARK30.86686042
78ABL20.83607227
79TAOK20.82331538
80STK240.81583272
81DAPK30.81497523
82SYK0.80012141
83TGFBR10.78988081
84LYN0.78362093
85LRRK20.74112153
86CSNK1G30.73136649
87FRK0.72073279
88TXK0.70884820
89PINK10.70709539
90BLK0.70604866
91JAK20.70570808
92MKNK20.70065776
93RPS6KA40.69150083
94HIPK20.68787123
95DAPK20.68081264
96IRAK40.67883342
97EIF2AK30.67221735
98CLK10.67162367
99CSNK1G10.66120550
100ZAP700.63685257
101DAPK10.63375328
102PIK3CG0.62963423
103CHEK20.62555352
104MAPK130.62489807
105AURKA0.62337583
106TRIM280.60153147
107TGFBR20.58786974
108ITK0.58387760
109MAPK110.57893551
110MAP2K70.57796218
111IKBKE0.57428852
112CHEK10.57182257
113MAP3K80.56273873
114PLK40.55722229
115EIF2AK20.55398136
116FLT30.55336669
117PRKCQ0.54800580
118STK30.51799437
119TNK20.50613694
120RPS6KA50.50032032
121CAMKK20.49939049
122CSNK1G20.49706363
123ATM0.48442765
124CDK80.48115698
125DYRK1B0.48009226
126BMPR20.47825819
127CSNK2A20.47629068
128MAP3K100.47075486
129PRKCI0.46724517
130CAMK10.45907117
131TRPM70.45194735
132CSNK2A10.43675330
133RPS6KA60.41841001
134BRD40.40660340
135MAP3K50.40429041
136PKN10.39404764
137CDK60.39182872
138CSF1R0.38843630
139MAPK40.38435875
140HCK0.38054717
141MAP3K120.37629798
142INSRR0.36331668
143RPS6KL10.35818587
144RPS6KC10.35818587
145PRKACG0.35810448
146LIMK10.35017592
147PLK30.34452832
148DYRK1A0.34397827
149CDK20.32833198
150GRK60.32513712

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.21153780
2Ribosome_Homo sapiens_hsa030104.67279826
3Mismatch repair_Homo sapiens_hsa034303.65260242
4Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008603.65126696
5Homologous recombination_Homo sapiens_hsa034402.85538049
6Base excision repair_Homo sapiens_hsa034102.75384928
7RNA polymerase_Homo sapiens_hsa030202.64409944
8Pyrimidine metabolism_Homo sapiens_hsa002402.54034772
9Spliceosome_Homo sapiens_hsa030402.53412906
10Nitrogen metabolism_Homo sapiens_hsa009102.43231985
11Nucleotide excision repair_Homo sapiens_hsa034202.38006106
12Proteasome_Homo sapiens_hsa030502.34491475
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.33959010
14Cell cycle_Homo sapiens_hsa041102.28612430
15Fanconi anemia pathway_Homo sapiens_hsa034602.16945350
16Non-homologous end-joining_Homo sapiens_hsa034501.93788228
17Fatty acid elongation_Homo sapiens_hsa000621.93395862
18RNA transport_Homo sapiens_hsa030131.92000349
19One carbon pool by folate_Homo sapiens_hsa006701.82600029
20Systemic lupus erythematosus_Homo sapiens_hsa053221.77030861
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.72790058
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.71528800
23SNARE interactions in vesicular transport_Homo sapiens_hsa041301.69893320
24Hematopoietic cell lineage_Homo sapiens_hsa046401.69697730
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.68322445
26Folate biosynthesis_Homo sapiens_hsa007901.57716916
27Sulfur relay system_Homo sapiens_hsa041221.55634253
28RNA degradation_Homo sapiens_hsa030181.53477885
29p53 signaling pathway_Homo sapiens_hsa041151.53052571
30alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.51654621
31Arachidonic acid metabolism_Homo sapiens_hsa005901.51570061
32Regulation of autophagy_Homo sapiens_hsa041401.39248107
33Purine metabolism_Homo sapiens_hsa002301.38315446
34Linoleic acid metabolism_Homo sapiens_hsa005911.36899014
35Pentose phosphate pathway_Homo sapiens_hsa000301.35837632
36Cardiac muscle contraction_Homo sapiens_hsa042601.34106598
37Basal transcription factors_Homo sapiens_hsa030221.33963469
38Herpes simplex infection_Homo sapiens_hsa051681.30524365
39Protein export_Homo sapiens_hsa030601.27101620
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.22005181
41Collecting duct acid secretion_Homo sapiens_hsa049661.20287990
42Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.18915402
43Sulfur metabolism_Homo sapiens_hsa009201.12260755
44Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.10283983
45Olfactory transduction_Homo sapiens_hsa047401.08664418
46Parkinsons disease_Homo sapiens_hsa050120.96229990
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.95713213
48Measles_Homo sapiens_hsa051620.95210026
49ABC transporters_Homo sapiens_hsa020100.95036752
50Antigen processing and presentation_Homo sapiens_hsa046120.94548879
51Primary immunodeficiency_Homo sapiens_hsa053400.93355770
52Phototransduction_Homo sapiens_hsa047440.90915783
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.90289078
54Vitamin B6 metabolism_Homo sapiens_hsa007500.89870235
55Selenocompound metabolism_Homo sapiens_hsa004500.89495062
56Viral carcinogenesis_Homo sapiens_hsa052030.87359400
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.81114850
58Alcoholism_Homo sapiens_hsa050340.79898185
59N-Glycan biosynthesis_Homo sapiens_hsa005100.79477480
60RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.79075744
61Legionellosis_Homo sapiens_hsa051340.77628751
62Epstein-Barr virus infection_Homo sapiens_hsa051690.74252618
63Huntingtons disease_Homo sapiens_hsa050160.68987523
64Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.68902071
65Steroid biosynthesis_Homo sapiens_hsa001000.67360983
66Fat digestion and absorption_Homo sapiens_hsa049750.67202984
67Drug metabolism - other enzymes_Homo sapiens_hsa009830.66857900
68Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.66189272
69Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.63598981
70Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.63265733
71Caffeine metabolism_Homo sapiens_hsa002320.62660473
72Small cell lung cancer_Homo sapiens_hsa052220.60933645
73Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60811121
74Platelet activation_Homo sapiens_hsa046110.60458391
75Glycerophospholipid metabolism_Homo sapiens_hsa005640.59020873
76mRNA surveillance pathway_Homo sapiens_hsa030150.58736431
77Ether lipid metabolism_Homo sapiens_hsa005650.57880959
78Apoptosis_Homo sapiens_hsa042100.57544319
79Acute myeloid leukemia_Homo sapiens_hsa052210.57247668
80Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.57091833
81Leishmaniasis_Homo sapiens_hsa051400.56957933
82Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.56795649
83Hepatitis B_Homo sapiens_hsa051610.56187105
84Propanoate metabolism_Homo sapiens_hsa006400.55522497
85Galactose metabolism_Homo sapiens_hsa000520.53906428
86Oxidative phosphorylation_Homo sapiens_hsa001900.52340095
87Serotonergic synapse_Homo sapiens_hsa047260.51548216
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51223034
89Pyruvate metabolism_Homo sapiens_hsa006200.49009168
90Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48799692
91Butanoate metabolism_Homo sapiens_hsa006500.48270258
92Thyroid cancer_Homo sapiens_hsa052160.48024931
93Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47855955
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47360374
95Chemical carcinogenesis_Homo sapiens_hsa052040.47149741
96Chronic myeloid leukemia_Homo sapiens_hsa052200.46929392
97Influenza A_Homo sapiens_hsa051640.44599101
98Steroid hormone biosynthesis_Homo sapiens_hsa001400.43222211
99Glutathione metabolism_Homo sapiens_hsa004800.42673975
100NF-kappa B signaling pathway_Homo sapiens_hsa040640.42468280
101Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.42405678
102Metabolic pathways_Homo sapiens_hsa011000.41498914
103Glycerolipid metabolism_Homo sapiens_hsa005610.40290341
104Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.39596697
105Jak-STAT signaling pathway_Homo sapiens_hsa046300.38609990
106Tryptophan metabolism_Homo sapiens_hsa003800.34874710
107Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.32899712
108Other glycan degradation_Homo sapiens_hsa005110.32053969
109Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31639517
110B cell receptor signaling pathway_Homo sapiens_hsa046620.31437141
111HTLV-I infection_Homo sapiens_hsa051660.30871313
112Shigellosis_Homo sapiens_hsa051310.30144559
113Biosynthesis of amino acids_Homo sapiens_hsa012300.28717099
114Alzheimers disease_Homo sapiens_hsa050100.28097744
115Tyrosine metabolism_Homo sapiens_hsa003500.26769097
116Intestinal immune network for IgA production_Homo sapiens_hsa046720.26709537
117Oocyte meiosis_Homo sapiens_hsa041140.25162926
118Malaria_Homo sapiens_hsa051440.23440699
119Carbon metabolism_Homo sapiens_hsa012000.21839890
120Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.20721264
121Toxoplasmosis_Homo sapiens_hsa051450.20466046
122Non-small cell lung cancer_Homo sapiens_hsa052230.20449397
123Retinol metabolism_Homo sapiens_hsa008300.19445063
124Asthma_Homo sapiens_hsa053100.18603932
125Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.17911566
126Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.17728820
127Pertussis_Homo sapiens_hsa051330.17474616
128Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.17351521
129Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.17291344
130Toll-like receptor signaling pathway_Homo sapiens_hsa046200.15997269
131Peroxisome_Homo sapiens_hsa041460.14977240
132Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.14897747
133beta-Alanine metabolism_Homo sapiens_hsa004100.14333630
134Vascular smooth muscle contraction_Homo sapiens_hsa042700.13918153
135Morphine addiction_Homo sapiens_hsa050320.13829817
136Colorectal cancer_Homo sapiens_hsa052100.12793106
137NOD-like receptor signaling pathway_Homo sapiens_hsa046210.12170724
138Fatty acid metabolism_Homo sapiens_hsa012120.11417819
139Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.11260575
140Primary bile acid biosynthesis_Homo sapiens_hsa001200.11114874
141African trypanosomiasis_Homo sapiens_hsa051430.06086292

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