MFNG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the fringe gene family which also includes radical and lunatic fringe genes. They all encode evolutionarily conserved secreted proteins that act in the Notch receptor pathway to demarcate boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe proteins have a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.41018351
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.53333891
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.53333891
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.24276737
5viral transcription (GO:0019083)5.18654781
6translational termination (GO:0006415)4.91771705
7antigen processing and presentation via MHC class Ib (GO:0002475)4.79584984
8antigen processing and presentation of endogenous antigen (GO:0019883)4.77880845
9positive regulation of gamma-delta T cell activation (GO:0046645)4.73341412
10maturation of SSU-rRNA (GO:0030490)4.54487561
11negative regulation of erythrocyte differentiation (GO:0045647)4.48331029
12positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.44783156
13translational elongation (GO:0006414)4.26096595
14definitive hemopoiesis (GO:0060216)4.25679811
15neutrophil activation involved in immune response (GO:0002283)4.18607292
16SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.15460877
17leukocyte aggregation (GO:0070486)4.06363499
18positive regulation of B cell differentiation (GO:0045579)4.04753010
19DNA deamination (GO:0045006)4.03325947
20cotranslational protein targeting to membrane (GO:0006613)4.02940106
21protein targeting to ER (GO:0045047)4.00573554
22positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.98518974
23T cell migration (GO:0072678)3.93810866
24ribosomal small subunit biogenesis (GO:0042274)3.93341006
25nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.91085218
26cellular response to interleukin-15 (GO:0071350)3.85782371
27viral life cycle (GO:0019058)3.85076909
28positive regulation by symbiont of host defense response (GO:0052509)3.84646766
29modulation by symbiont of host defense response (GO:0052031)3.84646766
30modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.84646766
31modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.84646766
32positive regulation by organism of defense response of other organism involved in symbiotic interact3.84646766
33modulation by symbiont of host immune response (GO:0052553)3.84646766
34regulation of gamma-delta T cell differentiation (GO:0045586)3.80314844
35establishment of protein localization to endoplasmic reticulum (GO:0072599)3.77319147
36protein localization to endoplasmic reticulum (GO:0070972)3.76816312
37thymic T cell selection (GO:0045061)3.75788890
38cellular protein complex disassembly (GO:0043624)3.73979214
39positive T cell selection (GO:0043368)3.71694902
40regulation of B cell receptor signaling pathway (GO:0050855)3.70218832
41Arp2/3 complex-mediated actin nucleation (GO:0034314)3.69817410
42T cell selection (GO:0045058)3.64898466
43regulation of B cell differentiation (GO:0045577)3.62072281
44negative regulation of lymphocyte mediated immunity (GO:0002707)3.56047626
45translational initiation (GO:0006413)3.55400678
46megakaryocyte development (GO:0035855)3.53510961
47lymphoid progenitor cell differentiation (GO:0002320)3.51530996
48detection of bacterium (GO:0016045)3.50422637
49protein complex disassembly (GO:0043241)3.49185661
50platelet dense granule organization (GO:0060155)3.45427786
51regulation of gamma-delta T cell activation (GO:0046643)3.45157884
52detection of other organism (GO:0098543)3.43690893
53negative regulation of T cell mediated immunity (GO:0002710)3.43581100
54response to peptidoglycan (GO:0032494)3.41298796
55tolerance induction (GO:0002507)3.37945963
56negative regulation of interleukin-12 production (GO:0032695)3.36216098
57B cell mediated immunity (GO:0019724)3.35737129
58T cell homeostasis (GO:0043029)3.34434568
59regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.32508955
60regulation of alpha-beta T cell proliferation (GO:0046640)3.32027578
61negative regulation of leukocyte mediated immunity (GO:0002704)3.29705205
62response to interferon-beta (GO:0035456)3.29572884
63macromolecular complex disassembly (GO:0032984)3.24853739
64regulation of mast cell degranulation (GO:0043304)3.24541623
65response to muramyl dipeptide (GO:0032495)3.23541959
66mature B cell differentiation involved in immune response (GO:0002313)3.22107243
67cellular extravasation (GO:0045123)3.21692554
68neutrophil activation (GO:0042119)3.19918459
69negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.19472329
70lymph node development (GO:0048535)3.16023020
71nuclear-transcribed mRNA catabolic process (GO:0000956)3.11622714
72DNA unwinding involved in DNA replication (GO:0006268)3.09770624
73defense response to protozoan (GO:0042832)3.07608494
74regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.07340096
753-UTR-mediated mRNA stabilization (GO:0070935)3.06802073
76regulation of T cell tolerance induction (GO:0002664)3.06215091
77respiratory burst (GO:0045730)3.06206185
78leukocyte degranulation (GO:0043299)3.05034065
79regulation of granulocyte differentiation (GO:0030852)3.04159346
80regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.03654101
81regulation of natural killer cell mediated immunity (GO:0002715)3.03654101
82negative regulation of innate immune response (GO:0045824)3.03574646
83regulation of interleukin-2 biosynthetic process (GO:0045076)3.03128700
84myeloid cell activation involved in immune response (GO:0002275)2.98732564
85positive regulation of alpha-beta T cell proliferation (GO:0046641)2.98366030
86DNA strand elongation involved in DNA replication (GO:0006271)2.98065170
87response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.98016861
88response to host immune response (GO:0052572)2.98016861
89mRNA catabolic process (GO:0006402)2.97515435
90CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.96756778
91interferon-gamma production (GO:0032609)2.96502391
92telomere maintenance via semi-conservative replication (GO:0032201)2.96469820
93regulation of antigen processing and presentation (GO:0002577)2.96108478
94regulation of mast cell activation involved in immune response (GO:0033006)2.94906410
95response to protozoan (GO:0001562)2.93248424
96negative regulation of phagocytosis (GO:0050765)2.92972835
97regulation of tolerance induction (GO:0002643)2.92900644
98regulation of dendritic cell antigen processing and presentation (GO:0002604)2.91469321
99DNA strand elongation (GO:0022616)2.91451258
100actin nucleation (GO:0045010)2.90780068
101positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.87267188
102response to interleukin-15 (GO:0070672)2.84776517
103granulocyte activation (GO:0036230)2.84315682
104regulation of myeloid leukocyte mediated immunity (GO:0002886)2.83883520
105mature B cell differentiation (GO:0002335)2.83470819
106negative thymic T cell selection (GO:0045060)2.82831478
107RNA catabolic process (GO:0006401)2.82622402
108mast cell activation (GO:0045576)2.82342435
109negative T cell selection (GO:0043383)2.80284281
110regulation of interleukin-12 biosynthetic process (GO:0045075)2.79559494
111regulation of mast cell activation (GO:0033003)2.78273555
112T cell receptor signaling pathway (GO:0050852)2.78255569
113NIK/NF-kappaB signaling (GO:0038061)2.77860181
114positive regulation of antigen processing and presentation (GO:0002579)2.77860129
115type I interferon signaling pathway (GO:0060337)2.77148708
116cellular response to type I interferon (GO:0071357)2.77148708
117response to type I interferon (GO:0034340)2.77089778
118interferon-gamma-mediated signaling pathway (GO:0060333)2.76822160
119activated T cell proliferation (GO:0050798)2.76050296
120positive thymic T cell selection (GO:0045059)2.75757257
121myeloid dendritic cell activation (GO:0001773)2.75616452
122endosome to melanosome transport (GO:0035646)2.75552395
123endosome to pigment granule transport (GO:0043485)2.75552395
124negative regulation of T-helper cell differentiation (GO:0045623)2.75310140
125negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.75310140
126positive regulation of B cell activation (GO:0050871)2.74215955
127macrophage activation involved in immune response (GO:0002281)2.74034419
128Peyers patch development (GO:0048541)2.73226853
129mucosal-associated lymphoid tissue development (GO:0048537)2.73226853
130positive regulation of T cell mediated cytotoxicity (GO:0001916)2.73136374
131leukocyte homeostasis (GO:0001776)2.73058861
132response to interferon-alpha (GO:0035455)2.72571994
133embryonic hemopoiesis (GO:0035162)2.71754918
134regulation of T cell mediated cytotoxicity (GO:0001914)2.71702599
135B cell receptor signaling pathway (GO:0050853)2.71261878
136ribosomal large subunit biogenesis (GO:0042273)2.69069058
137deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.66539858
138regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.65299512
139regulation of T cell receptor signaling pathway (GO:0050856)2.64489425
140immunoglobulin mediated immune response (GO:0016064)2.60179728
141lymphocyte homeostasis (GO:0002260)2.59712139
142secretory granule organization (GO:0033363)2.59690689
143venous blood vessel morphogenesis (GO:0048845)2.58725352
144negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.55661386
145negative regulation of cell killing (GO:0031342)2.55661386
146protein targeting to membrane (GO:0006612)2.54752055
147telomere maintenance via recombination (GO:0000722)2.51932910
148positive regulation of granulocyte differentiation (GO:0030854)2.50786652
149regulation of regulatory T cell differentiation (GO:0045589)2.47957320
150myeloid dendritic cell differentiation (GO:0043011)2.47519137
151morphogenesis of an endothelium (GO:0003159)2.46859283
152endothelial tube morphogenesis (GO:0061154)2.46859283
153negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.45796223
154positive regulation of isotype switching (GO:0045830)2.44212836
155regulation of erythrocyte differentiation (GO:0045646)2.44146557
156cellular response to interleukin-4 (GO:0071353)2.43576623
157negative regulation of RNA splicing (GO:0033119)2.41781800
158antigen receptor-mediated signaling pathway (GO:0050851)2.41714065
159mast cell degranulation (GO:0043303)2.41546182
160mast cell activation involved in immune response (GO:0002279)2.41546182

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.25872592
2SCL_19346495_ChIP-Seq_HPC-7_Human3.64362405
3ELF1_17652178_ChIP-ChIP_JURKAT_Human3.22507206
4* MYC_22102868_ChIP-Seq_BL_Human3.16525838
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.15615529
6IRF8_22096565_ChIP-ChIP_GC-B_Human2.97065452
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.96036150
8NOTCH1_21737748_ChIP-Seq_TLL_Human2.91943299
9RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.87721113
10* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.86925135
11SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.82226776
12VDR_21846776_ChIP-Seq_THP-1_Human2.76161631
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.76106899
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.71131111
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.65848177
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.64712789
17TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.59460751
18FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.54558823
19SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.41195209
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.15259804
21BP1_19119308_ChIP-ChIP_Hs578T_Human2.13795407
22* SPI1_23547873_ChIP-Seq_NB4_Human2.09222509
23CIITA_25753668_ChIP-Seq_RAJI_Human2.06166731
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.06000725
25STAT4_19710469_ChIP-ChIP_TH1__Mouse2.00566655
26* MAF_26560356_Chip-Seq_TH1_Human1.99253988
27* MYB_26560356_Chip-Seq_TH2_Human1.98371620
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.93582346
29IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.93257221
30LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.91662539
31ERG_20887958_ChIP-Seq_HPC-7_Mouse1.91032631
32SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.86403096
33ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.85401968
34VDR_24763502_ChIP-Seq_THP-1_Human1.84621925
35UTX_26944678_Chip-Seq_JUKART_Human1.84264217
36VDR_23849224_ChIP-Seq_CD4+_Human1.81359554
37XRN2_22483619_ChIP-Seq_HELA_Human1.80172083
38* MYB_26560356_Chip-Seq_TH1_Human1.79727205
39E2F4_17652178_ChIP-ChIP_JURKAT_Human1.79094245
40* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.78126508
41FOXP3_21729870_ChIP-Seq_TREG_Human1.78037474
42MYC_18358816_ChIP-ChIP_MESCs_Mouse1.77078565
43FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.76495022
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.75689199
45IRF8_21731497_ChIP-ChIP_J774_Mouse1.75450375
46RUNX_20019798_ChIP-Seq_JUKART_Human1.74945296
47MYB_21317192_ChIP-Seq_ERMYB_Mouse1.74206774
48* EST1_17652178_ChIP-ChIP_JURKAT_Human1.73893083
49GABP_17652178_ChIP-ChIP_JURKAT_Human1.73243863
50FOXM1_23109430_ChIP-Seq_U2OS_Human1.69990966
51* TCF7_22412390_ChIP-Seq_EML_Mouse1.69706555
52* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.69359116
53* RUNX1_22412390_ChIP-Seq_EML_Mouse1.69205409
54HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.68832545
55* ETS1_20019798_ChIP-Seq_JURKAT_Human1.67540641
56JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.66684157
57LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.64338125
58MYC_19079543_ChIP-ChIP_MESCs_Mouse1.60476786
59MYC_19030024_ChIP-ChIP_MESCs_Mouse1.59634785
60VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.56753756
61GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.53858447
62* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.50937454
63GATA1_19941827_ChIP-Seq_MEL_Mouse1.46424194
64FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.45396179
65* MAF_26560356_Chip-Seq_TH2_Human1.45190359
66GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.41581493
67KDM2B_26808549_Chip-Seq_DND41_Human1.40365801
68KDM2B_26808549_Chip-Seq_SUP-B15_Human1.39322882
69GATA1_22383799_ChIP-Seq_G1ME_Mouse1.38315407
70STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.37776905
71GATA3_26560356_Chip-Seq_TH2_Human1.35899467
72TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35687556
73ELF1_20517297_ChIP-Seq_JURKAT_Human1.34868267
74GATA2_22383799_ChIP-Seq_G1ME_Mouse1.34630057
75SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.33566615
76NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.32604407
77GABP_19822575_ChIP-Seq_HepG2_Human1.30504304
78CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.27317660
79NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.26508182
80SPI1_23127762_ChIP-Seq_K562_Human1.24162931
81SRF_21415370_ChIP-Seq_HL-1_Mouse1.22665251
82* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.22440906
83PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21622099
84GATA1_19941826_ChIP-Seq_K562_Human1.21255238
85BCOR_27268052_Chip-Seq_Bcells_Human1.20856624
86TTF2_22483619_ChIP-Seq_HELA_Human1.19104536
87PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18888049
88TP63_19390658_ChIP-ChIP_HaCaT_Human1.18703400
89CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18633665
90* ELK3_25401928_ChIP-Seq_HUVEC_Human1.18414344
91CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17996179
92E2F1_18555785_ChIP-Seq_MESCs_Mouse1.17934158
93IRF8_27001747_Chip-Seq_BMDM_Mouse1.16990425
94KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.16649976
95* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.15890453
96NELFA_20434984_ChIP-Seq_ESCs_Mouse1.14895260
97HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.14333572
98SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12633520
99THAP11_20581084_ChIP-Seq_MESCs_Mouse1.11215188
100SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10246691
101GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09367577
102CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.09116505
103* LXR_22292898_ChIP-Seq_THP-1_Human1.08197773
104SPI1_20517297_ChIP-Seq_HL60_Human1.08114242
105* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.08104368
106CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07344499
107VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.07269132
108RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.06703974
109* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06508214
110KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.06335373
111CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05053191
112CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.01905023
113P68_20966046_ChIP-Seq_HELA_Human1.01594029
114* P300_27268052_Chip-Seq_Bcells_Human1.00962632
115RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.00452160
116DCP1A_22483619_ChIP-Seq_HELA_Human1.00187714
117TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.00137438
118FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00010524
119* GATA3_27048872_Chip-Seq_THYMUS_Human0.99216848
120MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.98299260
121GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97786522
122NCOR1_26117541_ChIP-Seq_K562_Human0.97118590
123VDR_24787735_ChIP-Seq_THP-1_Human0.97048358
124* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.96525533
125CTCF_26484167_Chip-Seq_Bcells_Mouse0.96504875
126GATA1_22025678_ChIP-Seq_K562_Human0.95755514
127BCL6_27268052_Chip-Seq_Bcells_Human0.94881873
128CTCF_27219007_Chip-Seq_ERYTHROID_Human0.94388674
129IKZF1_21737484_ChIP-ChIP_HCT116_Human0.94078658
130PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94078092
131CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93833642
132EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.93259423
133BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.92734129

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system4.02871714
2MP0003763_abnormal_thymus_physiology3.68851346
3MP0001835_abnormal_antigen_presentation3.51782319
4MP0005671_abnormal_response_to3.50595680
5MP0000685_abnormal_immune_system3.14510389
6MP0009785_altered_susceptibility_to2.84243313
7MP0004808_abnormal_hematopoietic_stem2.76231465
8MP0005075_abnormal_melanosome_morpholog2.56441478
9MP0001800_abnormal_humoral_immune2.54343212
10MP0002398_abnormal_bone_marrow2.53066562
11MP0002420_abnormal_adaptive_immunity2.33479090
12MP0001819_abnormal_immune_cell2.30119850
13MP0005464_abnormal_platelet_physiology2.27668997
14MP0005025_abnormal_response_to2.23863311
15MP0000465_gastrointestinal_hemorrhage2.23182166
16MP0002723_abnormal_immune_serum2.22780697
17MP0002452_abnormal_antigen_presenting2.22650588
18MP0005174_abnormal_tail_pigmentation2.21054974
19MP0003724_increased_susceptibility_to2.19038416
20MP0003693_abnormal_embryo_hatching2.10515650
21* MP0000689_abnormal_spleen_morphology2.07302425
22* MP0000716_abnormal_immune_system2.07001646
23MP0005000_abnormal_immune_tolerance2.05982495
24MP0002722_abnormal_immune_system2.03351150
25MP0002166_altered_tumor_susceptibility2.03291857
26MP0000490_abnormal_crypts_of1.98564144
27MP0009333_abnormal_splenocyte_physiolog1.97066175
28MP0005387_immune_system_phenotype1.96439664
29MP0001790_abnormal_immune_system1.96439664
30MP0003436_decreased_susceptibility_to1.95818249
31MP0005397_hematopoietic_system_phenotyp1.94174239
32MP0001545_abnormal_hematopoietic_system1.94174239
33MP0001873_stomach_inflammation1.93157656
34* MP0002429_abnormal_blood_cell1.92200346
35MP0000703_abnormal_thymus_morphology1.89847671
36MP0010155_abnormal_intestine_physiology1.86755799
37MP0008007_abnormal_cellular_replicative1.72964599
38MP0003866_abnormal_defecation1.68200882
39MP0002405_respiratory_system_inflammati1.67487276
40MP0002148_abnormal_hypersensitivity_rea1.67385178
41MP0002419_abnormal_innate_immunity1.66759641
42MP0010094_abnormal_chromosome_stability1.60895876
43MP0010368_abnormal_lymphatic_system1.60608413
44MP0002095_abnormal_skin_pigmentation1.59975395
45MP0003077_abnormal_cell_cycle1.53433946
46MP0001879_abnormal_lymphatic_vessel1.51574389
47MP0008058_abnormal_DNA_repair1.47093070
48MP0006054_spinal_hemorrhage1.43895168
49MP0006292_abnormal_olfactory_placode1.43677287
50MP0002006_tumorigenesis1.42233402
51MP0009764_decreased_sensitivity_to1.41178939
52MP0002933_joint_inflammation1.34493825
53MP0009278_abnormal_bone_marrow1.30235630
54MP0001853_heart_inflammation1.29144292
55MP0001845_abnormal_inflammatory_respons1.27111787
56MP0003806_abnormal_nucleotide_metabolis1.26194433
57MP0005670_abnormal_white_adipose1.24222091
58MP0003943_abnormal_hepatobiliary_system1.23476899
59MP0004147_increased_porphyrin_level1.22333692
60MP0000015_abnormal_ear_pigmentation1.20196523
61MP0002019_abnormal_tumor_incidence1.19891393
62MP0000858_altered_metastatic_potential1.18352666
63MP0006082_CNS_inflammation1.17795346
64MP0003300_gastrointestinal_ulcer1.13708582
65MP0008260_abnormal_autophagy1.13386742
66MP0005310_abnormal_salivary_gland1.13286704
67MP0008057_abnormal_DNA_replication1.07585058
68MP0004957_abnormal_blastocyst_morpholog1.07109285
69MP0002138_abnormal_hepatobiliary_system1.06829537
70MP0005058_abnormal_lysosome_morphology1.04562411
71MP0003828_pulmonary_edema1.04156379
72MP0002277_abnormal_respiratory_mucosa1.03791060
73MP0003656_abnormal_erythrocyte_physiolo1.02684212
74MP0009379_abnormal_foot_pigmentation1.01865274
75MP0003315_abnormal_perineum_morphology1.01391516
76MP0005451_abnormal_body_composition1.00106810
77MP0000313_abnormal_cell_death0.96778507
78MP0002132_abnormal_respiratory_system0.96379642
79MP0004381_abnormal_hair_follicle0.95428769
80MP0003111_abnormal_nucleus_morphology0.93321131
81MP0001986_abnormal_taste_sensitivity0.91838948
82MP0008469_abnormal_protein_level0.90563674
83MP0000371_diluted_coat_color0.89585275
84MP0003075_altered_response_to0.87998439
85MP0000343_altered_response_to0.87106367
86MP0008004_abnormal_stomach_pH0.86525732
87MP0002075_abnormal_coat/hair_pigmentati0.84986838
88MP0009765_abnormal_xenobiotic_induced0.81281021
89MP0005084_abnormal_gallbladder_morpholo0.78722618
90MP0002653_abnormal_ependyma_morphology0.77676669
91MP0001533_abnormal_skeleton_physiology0.76378892
92MP0008961_abnormal_basal_metabolism0.75207027
93MP0000477_abnormal_intestine_morphology0.75092864
94MP0002998_abnormal_bone_remodeling0.75054205
95MP0001663_abnormal_digestive_system0.72765840
96MP0008995_early_reproductive_senescence0.71511140
97MP0000249_abnormal_blood_vessel0.71328632
98MP0005166_decreased_susceptibility_to0.68896486
99MP0005390_skeleton_phenotype0.68799195
100MP0003303_peritoneal_inflammation0.68288593
101MP0003191_abnormal_cellular_cholesterol0.68104328
102MP0003183_abnormal_peptide_metabolism0.67221407
103MP0004947_skin_inflammation0.66721191
104MP0005167_abnormal_blood-brain_barrier0.65784673
105MP0003786_premature_aging0.64003591
106MP0001851_eye_inflammation0.63560600
107MP0003172_abnormal_lysosome_physiology0.62235482
108MP0006036_abnormal_mitochondrial_physio0.61917960
109MP0005645_abnormal_hypothalamus_physiol0.61557835
110MP0008874_decreased_physiological_sensi0.61105220
111MP0003448_altered_tumor_morphology0.59614315
112MP0009763_increased_sensitivity_to0.59319049
113MP0000350_abnormal_cell_proliferation0.58866273
114MP0002970_abnormal_white_adipose0.56053674
115MP0004883_abnormal_blood_vessel0.55136457
116MP0002009_preneoplasia0.54755723
117MP0003795_abnormal_bone_structure0.54386748
118MP0000681_abnormal_thyroid_gland0.54305653
119MP0001186_pigmentation_phenotype0.53640380
120MP0004510_myositis0.53319500
121MP0001270_distended_abdomen0.52869239
122MP0005535_abnormal_body_temperature0.50518369
123MP0008873_increased_physiological_sensi0.50151000
124MP0009697_abnormal_copulation0.49518696
125MP0002693_abnormal_pancreas_physiology0.48944769
126MP0005381_digestive/alimentary_phenotyp0.48746303
127MP0009642_abnormal_blood_homeostasis0.44561668
128MP0000609_abnormal_liver_physiology0.44385325
129MP0000604_amyloidosis0.42531863
130MP0005584_abnormal_enzyme/coenzyme_acti0.40622097

Predicted human phenotypes

RankGene SetZ-score
1Thrombocytosis (HP:0001894)4.94933190
2IgM deficiency (HP:0002850)4.67172095
3Elevated erythrocyte sedimentation rate (HP:0003565)4.54387973
4Chronic otitis media (HP:0000389)4.47113018
5Aplastic anemia (HP:0001915)4.46926851
6Prolonged bleeding time (HP:0003010)4.08763791
7Myositis (HP:0100614)3.84735545
8Orchitis (HP:0100796)3.84622271
9Recurrent bronchitis (HP:0002837)3.82653371
10Encephalitis (HP:0002383)3.81280651
11Panhypogammaglobulinemia (HP:0003139)3.77612735
12Abnormality of macrophages (HP:0004311)3.77295216
13B lymphocytopenia (HP:0010976)3.73501595
14Abnormality of B cell number (HP:0010975)3.73501595
15Mediastinal lymphadenopathy (HP:0100721)3.70072294
16Abnormality of cells of the erythroid lineage (HP:0012130)3.66283762
17Optic neuritis (HP:0100653)3.64657126
18Retrobulbar optic neuritis (HP:0100654)3.64657126
19Reticulocytopenia (HP:0001896)3.58103433
20Abnormal number of erythroid precursors (HP:0012131)3.57654761
21Abnormality of the nasal mucosa (HP:0000433)3.57081161
22Abnormal delayed hypersensitivity skin test (HP:0002963)3.46847665
23Increased IgM level (HP:0003496)3.30310234
24Abnormality of T cells (HP:0002843)3.13715320
25Nasal polyposis (HP:0100582)3.09166798
26Spontaneous hematomas (HP:0007420)3.07857293
27Gastrointestinal inflammation (HP:0004386)3.05296975
28Gingival bleeding (HP:0000225)3.04952896
29Agammaglobulinemia (HP:0004432)3.04698662
30Autoimmune hemolytic anemia (HP:0001890)3.04384701
31Epistaxis (HP:0000421)2.98382098
32Abnormality of T cell physiology (HP:0011840)2.96136262
33Recurrent gram-negative bacterial infections (HP:0005420)2.95643782
34Petechiae (HP:0000967)2.88234609
35Gastrointestinal infarctions (HP:0005244)2.87026121
36Recurrent viral infections (HP:0004429)2.85883246
37Abnormal platelet volume (HP:0011876)2.84155706
38Inflammation of the large intestine (HP:0002037)2.83937714
39Reduced antithrombin III activity (HP:0001976)2.83408221
40Pustule (HP:0200039)2.80255266
41Recurrent abscess formation (HP:0002722)2.79663648
42Type I transferrin isoform profile (HP:0003642)2.77904176
43Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.75964573
44Abnormal protein N-linked glycosylation (HP:0012347)2.75964573
45Abnormal protein glycosylation (HP:0012346)2.75964573
46Abnormal glycosylation (HP:0012345)2.75964573
47Abnormality of the fingertips (HP:0001211)2.75407565
48Meningitis (HP:0001287)2.75030940
49Recurrent fungal infections (HP:0002841)2.74708774
50Pulmonary infiltrates (HP:0002113)2.72789642
51Keratoconjunctivitis sicca (HP:0001097)2.71790111
52Hypoproteinemia (HP:0003075)2.70336466
53Abnormality of the heme biosynthetic pathway (HP:0010472)2.70224852
54T lymphocytopenia (HP:0005403)2.69965248
55Eosinophilia (HP:0001880)2.66946042
56Urticaria (HP:0001025)2.64341048
57Lymphopenia (HP:0001888)2.64233857
58Acute lymphatic leukemia (HP:0006721)2.64177850
59Impaired platelet aggregation (HP:0003540)2.61120344
60Abnormal platelet function (HP:0011869)2.61120344
61Lymphoma (HP:0002665)2.60341836
62IgG deficiency (HP:0004315)2.59836078
63Hypergammaglobulinemia (HP:0010702)2.59459592
64Abnormality of cells of the lymphoid lineage (HP:0012140)2.58255414
65Keratoconjunctivitis (HP:0001096)2.54144416
66Severe combined immunodeficiency (HP:0004430)2.52338327
67Abnormality of T cell number (HP:0011839)2.51985420
68Cellulitis (HP:0100658)2.50501838
69Hemoptysis (HP:0002105)2.48892768
70Thyroiditis (HP:0100646)2.48173579
71Acute myeloid leukemia (HP:0004808)2.47304606
72Recurrent bacterial skin infections (HP:0005406)2.42347454
73Autoimmune thrombocytopenia (HP:0001973)2.41236442
74Sepsis (HP:0100806)2.41190975
75Eczematoid dermatitis (HP:0000976)2.40959392
76Hepatosplenomegaly (HP:0001433)2.40938658
77Arterial thrombosis (HP:0004420)2.40085467
78Pallor (HP:0000980)2.39465119
79Acute hepatic failure (HP:0006554)2.38394652
80Amaurosis fugax (HP:0100576)2.38117430
81Chronic sinusitis (HP:0011109)2.35723171
82Chronic mucocutaneous candidiasis (HP:0002728)2.35610914
83Recurrent cutaneous fungal infections (HP:0011370)2.35610914
84Muscle fiber atrophy (HP:0100295)2.31685683
85Combined immunodeficiency (HP:0005387)2.27153148
86Increased mean platelet volume (HP:0011877)2.26626863
87Pulmonary embolism (HP:0002204)2.26467957
88Menorrhagia (HP:0000132)2.26305233
89Interstitial pulmonary disease (HP:0006530)2.25645838
90Verrucae (HP:0200043)2.25532836
91Papilloma (HP:0012740)2.25532836
92Stomatitis (HP:0010280)2.24714179
93Aplasia/Hypoplasia of the thymus (HP:0010515)2.24330539
94Hematochezia (HP:0002573)2.24005876
95Osteomyelitis (HP:0002754)2.23149678
96Myelodysplasia (HP:0002863)2.22453785
97Abnormality of iron homeostasis (HP:0011031)2.21382543
98Increased serum ferritin (HP:0003281)2.20913966
99Skin rash (HP:0000988)2.18912151
10011 pairs of ribs (HP:0000878)2.18762277
101Hypertensive crisis (HP:0100735)2.17781960
102Optic nerve coloboma (HP:0000588)2.16956377
103Albinism (HP:0001022)2.16559609
104Abnormality of the pleura (HP:0002103)2.16318178
105Episodic fever (HP:0001954)2.15130142
106Hypochromic anemia (HP:0001931)2.14822456
107Microcytic anemia (HP:0001935)2.14255645
108Bronchitis (HP:0012387)2.14178188
109Recurrent sinusitis (HP:0011108)2.13831599
110Colitis (HP:0002583)2.12178050
111Chest pain (HP:0100749)2.12101371
112Gingivitis (HP:0000230)2.11179132
113Abnormality of eosinophils (HP:0001879)2.09993385
114Prostate neoplasm (HP:0100787)2.09772895
115Asplenia (HP:0001746)2.09600472
116Type 2 muscle fiber atrophy (HP:0003554)2.08731237
117Bicuspid aortic valve (HP:0001647)2.07769917
118Severe visual impairment (HP:0001141)2.07463130
119Purpura (HP:0000979)2.06992056
120Recurrent skin infections (HP:0001581)2.05246862
121Abnormality of the intervertebral disk (HP:0005108)2.04944680
122Abnormality of the prostate (HP:0008775)2.04934973
123Macrocytic anemia (HP:0001972)2.04674194
124Hypoplasia of the thymus (HP:0000778)2.03635852
125Pulmonary fibrosis (HP:0002206)2.03103759
126Joint swelling (HP:0001386)2.03062130
127Pancytopenia (HP:0001876)2.00227570
128Chronic diarrhea (HP:0002028)2.00170388
129Granulocytopenia (HP:0001913)1.99881659
130Vasculitis (HP:0002633)1.98856476
131Gastrointestinal stroma tumor (HP:0100723)1.96989918
132Abnormality of the columella (HP:0009929)1.96910067
133Chronic obstructive pulmonary disease (HP:0006510)1.95389061
134Obstructive lung disease (HP:0006536)1.95389061
135Increased IgE level (HP:0003212)1.94602505
136Absent rod-and cone-mediated responses on ERG (HP:0007688)1.93150407
137Skin ulcer (HP:0200042)1.92980714
138Aplasia/Hypoplasia of the spleen (HP:0010451)1.92699170
139Thyroid-stimulating hormone excess (HP:0002925)1.90152582
140Hypothermia (HP:0002045)1.88954788
141Poikiloderma (HP:0001029)1.87485779
142Leukocytosis (HP:0001974)1.84381133
143Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.84336778
144Decreased activity of mitochondrial respiratory chain (HP:0008972)1.84336778

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.92405560
2RIPK43.13412515
3TGFBR13.07523855
4KIT2.91012815
5TGFBR22.75826321
6TESK22.73473823
7TIE12.61530141
8TAOK32.56236684
9EEF2K2.39671351
10FLT32.36404491
11BTK2.32469471
12TXK2.28486618
13KDR2.26815214
14ZAP702.20726399
15NME22.20073758
16TEC2.10946808
17CSF1R1.97886257
18MAP3K111.96621091
19JAK31.96361825
20PRPF4B1.94403973
21TNIK1.81639701
22SIK31.80716977
23NLK1.62228183
24ACVR1B1.46637789
25FGFR41.46211470
26TBK11.44949827
27BLK1.41877845
28MAP2K31.40534580
29IKBKE1.36366416
30CDK81.35401499
31IRAK41.35311638
32ITK1.33551144
33CDK191.32469534
34TYK21.32428861
35SYK1.29880810
36MAP3K101.26773002
37PASK1.25914659
38STK101.23137213
39VRK21.20815340
40WEE11.19423011
41ADRBK21.18084182
42DYRK31.16116728
43LCK1.14418742
44SRPK11.11619998
45LRRK21.11180169
46RPS6KA41.09495020
47SCYL21.07911807
48IKBKB1.04391955
49CDK91.02534521
50CDK40.99325488
51PKN20.98648840
52PRKCQ0.96596747
53FGFR30.95136598
54CCNB10.94563028
55STK160.93530779
56PRKG20.91848285
57MUSK0.91106689
58FES0.91106015
59LYN0.90958943
60TAOK20.90361351
61RPS6KB20.89992599
62ERN10.86403397
63MELK0.85901688
64MAP2K20.84047103
65EPHA30.83676701
66HCK0.83492899
67MKNK10.82241002
68TLK10.82196306
69VRK10.82055377
70BRSK10.81876269
71PAK40.81584752
72NEK20.81180814
73GRK60.81071812
74TAOK10.80375316
75TSSK60.79958022
76BCKDK0.79171639
77PIM10.78749517
78BUB10.78093375
79CDK70.77932183
80NUAK10.77617809
81MATK0.75793423
82MAPKAPK30.75493339
83MAP3K10.74487863
84BRSK20.74308205
85CHUK0.74051593
86BRD40.73124310
87FGR0.72939357
88MAP3K60.72490002
89CLK10.71738205
90MARK30.70636667
91SIK20.69793347
92MAP2K60.68380753
93MAP3K120.67817518
94MAP4K20.66766149
95BMPR1B0.66582685
96MAP3K30.66398856
97ATR0.65325529
98SMG10.65286629
99EPHB10.62599153
100CDK60.62033726
101PDK10.60648071
102PIK3CG0.60407956
103HIPK20.60097821
104RAF10.59855580
105JAK10.59480364
106MAPK110.58787222
107MAPK120.58125985
108MAPK40.57962939
109CAMKK20.56711103
110FYN0.56307315
111RPS6KL10.55876059
112RPS6KC10.55876059
113CDC70.53339751
114MAP3K140.52705612
115MAP3K70.51488895
116RPS6KA60.50376849
117DAPK10.50158271
118AURKB0.48421734
119MAPK70.48351794
120CAMKK10.48295380
121YES10.48208958
122ARAF0.45663443
123TNK20.44448075
124BMPR20.44271821
125PRKD20.43143553
126MAPKAPK20.42711606
127MAP3K130.42135150
128TRIB30.41990613
129MAP3K50.41686964
130CSK0.41061510
131PTK2B0.37759288
132PIM20.36433134
133MAPK30.34628972
134MARK20.33461543
135JAK20.33243955
136IRAK10.32301068
137SIK10.32161584
138PRKCD0.30802755
139BMX0.30210531
140ABL10.28618548
141GRK70.24545102
142DYRK1B0.24536119

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.02365981
2DNA replication_Homo sapiens_hsa030303.79430446
3Primary immunodeficiency_Homo sapiens_hsa053403.67192560
4Mismatch repair_Homo sapiens_hsa034302.85551876
5Base excision repair_Homo sapiens_hsa034102.69436557
6Type I diabetes mellitus_Homo sapiens_hsa049402.51334544
7Spliceosome_Homo sapiens_hsa030402.40124706
8Staphylococcus aureus infection_Homo sapiens_hsa051502.26121714
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.06459447
10Measles_Homo sapiens_hsa051622.04144395
11Homologous recombination_Homo sapiens_hsa034401.99818172
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.92126880
13B cell receptor signaling pathway_Homo sapiens_hsa046621.85676078
14NF-kappa B signaling pathway_Homo sapiens_hsa040641.81679818
15Leishmaniasis_Homo sapiens_hsa051401.75559730
16Herpes simplex infection_Homo sapiens_hsa051681.75324013
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.70067995
18Hematopoietic cell lineage_Homo sapiens_hsa046401.66842849
19Antigen processing and presentation_Homo sapiens_hsa046121.64141732
20* Notch signaling pathway_Homo sapiens_hsa043301.62348907
21Intestinal immune network for IgA production_Homo sapiens_hsa046721.62207808
22T cell receptor signaling pathway_Homo sapiens_hsa046601.56068472
23Non-homologous end-joining_Homo sapiens_hsa034501.55355241
24Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.52403284
25Transcriptional misregulation in cancer_Homo sapiens_hsa052021.49622918
26Nucleotide excision repair_Homo sapiens_hsa034201.49031514
27Cell cycle_Homo sapiens_hsa041101.46980528
28Jak-STAT signaling pathway_Homo sapiens_hsa046301.42870363
29Pyrimidine metabolism_Homo sapiens_hsa002401.42217731
30Allograft rejection_Homo sapiens_hsa053301.37432703
31Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.36397347
32Acute myeloid leukemia_Homo sapiens_hsa052211.35144259
33RNA polymerase_Homo sapiens_hsa030201.30647005
34Osteoclast differentiation_Homo sapiens_hsa043801.27853459
35Rheumatoid arthritis_Homo sapiens_hsa053231.27174174
36Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.24676816
37RNA degradation_Homo sapiens_hsa030181.22036367
38Shigellosis_Homo sapiens_hsa051311.21350456
39Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.18066591
40Toll-like receptor signaling pathway_Homo sapiens_hsa046201.15001237
41Hepatitis B_Homo sapiens_hsa051611.13804739
42Platelet activation_Homo sapiens_hsa046111.11229324
43Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.10088945
44N-Glycan biosynthesis_Homo sapiens_hsa005101.07865688
45Epstein-Barr virus infection_Homo sapiens_hsa051691.03973170
46Influenza A_Homo sapiens_hsa051641.02105875
47Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.01913742
48Fanconi anemia pathway_Homo sapiens_hsa034601.01418632
49RNA transport_Homo sapiens_hsa030131.00564115
50HTLV-I infection_Homo sapiens_hsa051661.00363980
51Legionellosis_Homo sapiens_hsa051340.97431137
52Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.97089785
53SNARE interactions in vesicular transport_Homo sapiens_hsa041300.95212497
54Proteasome_Homo sapiens_hsa030500.92996229
55Chronic myeloid leukemia_Homo sapiens_hsa052200.92988509
56Phagosome_Homo sapiens_hsa041450.92935770
57Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.89559661
58Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.89511236
59Pertussis_Homo sapiens_hsa051330.88110166
60Leukocyte transendothelial migration_Homo sapiens_hsa046700.87170200
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.86869029
62p53 signaling pathway_Homo sapiens_hsa041150.84972761
63Apoptosis_Homo sapiens_hsa042100.83293724
64Other glycan degradation_Homo sapiens_hsa005110.83001101
65Toxoplasmosis_Homo sapiens_hsa051450.81018929
66NOD-like receptor signaling pathway_Homo sapiens_hsa046210.79563511
67Basal transcription factors_Homo sapiens_hsa030220.79167006
68Thyroid cancer_Homo sapiens_hsa052160.77701450
69African trypanosomiasis_Homo sapiens_hsa051430.76757798
70Malaria_Homo sapiens_hsa051440.75962183
71Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.75211418
72Pancreatic cancer_Homo sapiens_hsa052120.75171726
73Colorectal cancer_Homo sapiens_hsa052100.74709471
74Viral carcinogenesis_Homo sapiens_hsa052030.73321417
75Caffeine metabolism_Homo sapiens_hsa002320.71798646
76AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.70703593
77Purine metabolism_Homo sapiens_hsa002300.70485492
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68574460
79Autoimmune thyroid disease_Homo sapiens_hsa053200.66540249
80Sulfur relay system_Homo sapiens_hsa041220.66233999
81Viral myocarditis_Homo sapiens_hsa054160.64224824
82Systemic lupus erythematosus_Homo sapiens_hsa053220.63417442
83TNF signaling pathway_Homo sapiens_hsa046680.60558605
84mRNA surveillance pathway_Homo sapiens_hsa030150.60431659
85Neurotrophin signaling pathway_Homo sapiens_hsa047220.60412720
86Graft-versus-host disease_Homo sapiens_hsa053320.57953078
87Protein export_Homo sapiens_hsa030600.56872490
88Regulation of autophagy_Homo sapiens_hsa041400.56756907
89Glycerophospholipid metabolism_Homo sapiens_hsa005640.55564555
90Chemokine signaling pathway_Homo sapiens_hsa040620.55454368
91Glycosaminoglycan degradation_Homo sapiens_hsa005310.54769198
92Pentose phosphate pathway_Homo sapiens_hsa000300.53874797
93Arachidonic acid metabolism_Homo sapiens_hsa005900.52418877
94Asthma_Homo sapiens_hsa053100.51666470
95Non-small cell lung cancer_Homo sapiens_hsa052230.51249806
96Endocytosis_Homo sapiens_hsa041440.51106770
97Prolactin signaling pathway_Homo sapiens_hsa049170.50475084
98One carbon pool by folate_Homo sapiens_hsa006700.46985619
99Hepatitis C_Homo sapiens_hsa051600.46937956
100Small cell lung cancer_Homo sapiens_hsa052220.46910689
101Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.43535041
102Lysosome_Homo sapiens_hsa041420.42998007
103Folate biosynthesis_Homo sapiens_hsa007900.42732052
104Tuberculosis_Homo sapiens_hsa051520.42072091
105Salmonella infection_Homo sapiens_hsa051320.41770111
106VEGF signaling pathway_Homo sapiens_hsa043700.41222993
107Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.40981015
108Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40504584
109Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.39081555
110Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37723863
111Sphingolipid signaling pathway_Homo sapiens_hsa040710.37311030
112Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.36250366
113Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.35214363
114Pathways in cancer_Homo sapiens_hsa052000.35074494
115Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.33324522
116Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.32268843
117Carbohydrate digestion and absorption_Homo sapiens_hsa049730.28928030
118alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28629595
119Adipocytokine signaling pathway_Homo sapiens_hsa049200.27627151
120Phosphatidylinositol signaling system_Homo sapiens_hsa040700.24951670
121MAPK signaling pathway_Homo sapiens_hsa040100.23725296
122Phospholipase D signaling pathway_Homo sapiens_hsa040720.19165264
123Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.18993595
124Inositol phosphate metabolism_Homo sapiens_hsa005620.17258814
125Choline metabolism in cancer_Homo sapiens_hsa052310.16829609
126Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.16071430
127FoxO signaling pathway_Homo sapiens_hsa040680.12348191

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