MFF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This is a nuclear gene encoding a protein that functions in mitochondrial and peroxisomal fission. The encoded protein recruits dynamin-1-like protein (DNM1L) to mitochondria. There are multiple pseudogenes for this gene on chromosomes 1, 5, and X. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.11611817
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.05877351
3synapsis (GO:0007129)5.05200209
4synaptic vesicle exocytosis (GO:0016079)4.96938567
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.95618455
6cellular potassium ion homeostasis (GO:0030007)4.85998120
7locomotory exploration behavior (GO:0035641)4.68224531
8sodium ion export (GO:0071436)4.59663929
9regulation of synaptic vesicle exocytosis (GO:2000300)4.58117695
10glutamate secretion (GO:0014047)4.47171317
11neuronal action potential propagation (GO:0019227)4.42369670
12regulation of meiosis I (GO:0060631)4.29155226
13layer formation in cerebral cortex (GO:0021819)4.27296616
14regulation of synaptic vesicle transport (GO:1902803)4.26534811
15positive regulation of potassium ion transmembrane transporter activity (GO:1901018)4.24553139
16piRNA metabolic process (GO:0034587)4.16477331
17positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.11904047
18male meiosis I (GO:0007141)4.01727335
19vocalization behavior (GO:0071625)3.93910147
20cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.93694088
21protein localization to synapse (GO:0035418)3.91873717
22regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.90122019
23regulation of synapse structural plasticity (GO:0051823)3.88343131
24protein neddylation (GO:0045116)3.83357862
25cell communication by electrical coupling (GO:0010644)3.82834976
26neurotransmitter secretion (GO:0007269)3.82692285
27ionotropic glutamate receptor signaling pathway (GO:0035235)3.80969511
28cullin deneddylation (GO:0010388)3.77866349
29gamma-aminobutyric acid transport (GO:0015812)3.75095654
30neuron cell-cell adhesion (GO:0007158)3.74945546
31exploration behavior (GO:0035640)3.74705946
32chromosome organization involved in meiosis (GO:0070192)3.74306752
33response to pheromone (GO:0019236)3.70826558
34synaptic vesicle docking involved in exocytosis (GO:0016081)3.67984920
35glutamate receptor signaling pathway (GO:0007215)3.67431792
36regulation of glutamate receptor signaling pathway (GO:1900449)3.64704803
37membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.62361752
38regulation of neuronal synaptic plasticity (GO:0048168)3.58334969
39male meiosis (GO:0007140)3.55096358
40regulation of long-term neuronal synaptic plasticity (GO:0048169)3.54770507
41meiosis I (GO:0007127)3.52270476
42synaptic transmission, glutamatergic (GO:0035249)3.52223411
43positive regulation of potassium ion transmembrane transport (GO:1901381)3.51620165
44innervation (GO:0060384)3.39260931
45neuron-neuron synaptic transmission (GO:0007270)3.38681484
46proline transport (GO:0015824)3.37718477
47CENP-A containing nucleosome assembly (GO:0034080)3.36684125
48activation of protein kinase A activity (GO:0034199)3.35965991
49potassium ion import (GO:0010107)3.35826470
50cellular sodium ion homeostasis (GO:0006883)3.33735291
51chromatin remodeling at centromere (GO:0031055)3.32777937
52neuron recognition (GO:0008038)3.30447490
53protein deneddylation (GO:0000338)3.29230999
54chaperone-mediated protein transport (GO:0072321)3.28041101
55long-term memory (GO:0007616)3.27174141
56potassium ion homeostasis (GO:0055075)3.24290373
57neurotransmitter transport (GO:0006836)3.23720807
58DNA methylation involved in gamete generation (GO:0043046)3.19662140
59regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.18184639
60synaptonemal complex assembly (GO:0007130)3.17616905
61G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.15973918
62tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.14348064
63RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.14348064
64mitochondrial respiratory chain complex I assembly (GO:0032981)3.14278894
65NADH dehydrogenase complex assembly (GO:0010257)3.14278894
66mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.14278894
67gamma-aminobutyric acid signaling pathway (GO:0007214)3.13793600
68synaptic vesicle endocytosis (GO:0048488)3.13118930
69positive regulation of synapse maturation (GO:0090129)3.11943454
70resolution of meiotic recombination intermediates (GO:0000712)3.10709947
71regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.10707991
72histone exchange (GO:0043486)3.09123982
73regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.06594453
74regulation of vesicle fusion (GO:0031338)3.06212043
75membrane depolarization during action potential (GO:0086010)3.05801578
76synaptonemal complex organization (GO:0070193)3.03815099
77mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.03517200
78neurofilament cytoskeleton organization (GO:0060052)3.02174635
79neurotransmitter-gated ion channel clustering (GO:0072578)3.00384412
80vesicle transport along microtubule (GO:0047496)2.99451286
81intraciliary transport (GO:0042073)2.99186439
82axonal fasciculation (GO:0007413)2.98494501
83response to auditory stimulus (GO:0010996)2.98395058
84cerebellar Purkinje cell differentiation (GO:0021702)2.97609587
85auditory behavior (GO:0031223)2.97279565
86regulation of dendritic spine morphogenesis (GO:0061001)2.97102079
87detection of calcium ion (GO:0005513)2.95573304
88protein complex biogenesis (GO:0070271)2.95428288
89regulation of neurotransmitter levels (GO:0001505)2.93950453
90proteasome assembly (GO:0043248)2.93477548
91regulation of excitatory postsynaptic membrane potential (GO:0060079)2.93189050
92dendritic spine morphogenesis (GO:0060997)2.92998896
93negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.92963396
94positive regulation of membrane potential (GO:0045838)2.91931580
95positive regulation of synaptic transmission, GABAergic (GO:0032230)2.91673704
96negative regulation of cytosolic calcium ion concentration (GO:0051481)2.91282365
97regulation of synaptic plasticity (GO:0048167)2.90164931
98positive regulation of potassium ion transport (GO:0043268)2.88856288
99regulation of synaptic transmission, glutamatergic (GO:0051966)2.88673429
100meiotic nuclear division (GO:0007126)2.88637131
101transmission of nerve impulse (GO:0019226)2.88363998
102regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.88323704
103regulation of postsynaptic membrane potential (GO:0060078)2.87255306
104regulation of neurotransmitter secretion (GO:0046928)2.85775285
105dendrite morphogenesis (GO:0048813)2.84954631
106mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.84098970
107regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.83816412
108membrane repolarization (GO:0086009)2.83623466
109long-term synaptic potentiation (GO:0060291)2.81560564
110organelle transport along microtubule (GO:0072384)2.81012652
111mitochondrial respiratory chain complex assembly (GO:0033108)2.78257571
112seminiferous tubule development (GO:0072520)2.78206571
113establishment of synaptic vesicle localization (GO:0097480)2.77902204
114synaptic vesicle transport (GO:0048489)2.77902204
115regulation of ARF protein signal transduction (GO:0032012)2.77887892
116regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.77006107
117behavioral defense response (GO:0002209)2.77000578
118behavioral fear response (GO:0001662)2.77000578
119histone H2A acetylation (GO:0043968)2.76413912
120positive regulation of dendritic spine development (GO:0060999)2.76014509
121regulation of membrane repolarization (GO:0060306)2.74995294
122positive regulation of neurotransmitter secretion (GO:0001956)2.74633714
123pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.74561806
124negative regulation of microtubule polymerization (GO:0031115)2.74051450
125regulation of potassium ion transmembrane transport (GO:1901379)2.73553052
126axon cargo transport (GO:0008088)2.72703919
127* positive regulation of mitochondrial fission (GO:0090141)2.72256326
128fear response (GO:0042596)2.71917042
129iron-sulfur cluster assembly (GO:0016226)2.71821926
130metallo-sulfur cluster assembly (GO:0031163)2.71821926
131meiotic cell cycle process (GO:1903046)2.71509479
132membrane hyperpolarization (GO:0060081)2.70253452
133synapse assembly (GO:0007416)2.69695615
134regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.69561519
135nonmotile primary cilium assembly (GO:0035058)2.69251840
136postsynaptic membrane organization (GO:0001941)2.68843943
137negative regulation of synaptic transmission, GABAergic (GO:0032229)2.68299552
138neuromuscular process controlling balance (GO:0050885)2.68030318
139synapse organization (GO:0050808)2.67806262
140regulation of neurotransmitter transport (GO:0051588)2.67032078
141regulation of cilium movement (GO:0003352)2.66518258
142negative regulation of heart rate (GO:0010459)2.66344629
143positive regulation of dendritic spine morphogenesis (GO:0061003)2.64497837
144ADP metabolic process (GO:0046031)2.64400443
145oxidative phosphorylation (GO:0006119)2.59701816
146DNA damage response, detection of DNA damage (GO:0042769)2.58858165
147regulation of coenzyme metabolic process (GO:0051196)2.58627029
148regulation of cofactor metabolic process (GO:0051193)2.58627029
149aminoglycoside antibiotic metabolic process (GO:0030647)2.55441249
150regulation of mitochondrial translation (GO:0070129)2.54895598
151regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.52237653
152ATP synthesis coupled proton transport (GO:0015986)2.48109252
153energy coupled proton transport, down electrochemical gradient (GO:0015985)2.48109252
154* protein targeting to mitochondrion (GO:0006626)2.45771416
155negative regulation of appetite (GO:0032099)2.45096088
156negative regulation of response to food (GO:0032096)2.45096088
157protein localization to cilium (GO:0061512)2.44728038
158reciprocal meiotic recombination (GO:0007131)2.44641718
159reciprocal DNA recombination (GO:0035825)2.44641718
160ribonucleoprotein complex disassembly (GO:0032988)2.44389130
161respiratory electron transport chain (GO:0022904)2.44135935
162DNA replication-independent nucleosome assembly (GO:0006336)2.43530308
163DNA replication-independent nucleosome organization (GO:0034724)2.43530308
164SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)2.43320251
165positive regulation of meiosis (GO:0045836)2.43044170
166presynaptic membrane organization (GO:0097090)2.42491783
167regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.41715708
168ribosomal small subunit assembly (GO:0000028)2.41532241
169establishment of integrated proviral latency (GO:0075713)2.41032502
170binding of sperm to zona pellucida (GO:0007339)2.40539408
171* protein localization to mitochondrion (GO:0070585)2.39529176
172ubiquinone biosynthetic process (GO:0006744)2.38977495
173peptidyl-arginine N-methylation (GO:0035246)2.38471468
174peptidyl-arginine methylation (GO:0018216)2.38471468
175pyrimidine nucleobase catabolic process (GO:0006208)2.37783377
176ribosomal large subunit biogenesis (GO:0042273)2.37429633
177sperm motility (GO:0030317)2.35849600
178pyrimidine nucleotide catabolic process (GO:0006244)2.35604549
179establishment of melanosome localization (GO:0032401)2.34935654
180ubiquinone metabolic process (GO:0006743)2.34508324
181de novo protein folding (GO:0006458)2.34306775
182establishment of protein localization to mitochondrial membrane (GO:0090151)2.33644597
183electron transport chain (GO:0022900)2.33476959
184melanosome transport (GO:0032402)2.30523066
185regulation of acyl-CoA biosynthetic process (GO:0050812)2.30053594
186respiratory chain complex IV assembly (GO:0008535)2.29647920
187polyketide metabolic process (GO:0030638)2.29218144
188doxorubicin metabolic process (GO:0044598)2.29218144
189daunorubicin metabolic process (GO:0044597)2.29218144
190rRNA modification (GO:0000154)2.28624453
191acrosome reaction (GO:0007340)2.28315178
192* establishment of protein localization to mitochondrion (GO:0072655)2.27864805
193centriole replication (GO:0007099)2.27750884
194spermatid development (GO:0007286)2.27504871
195aerobic respiration (GO:0009060)2.27474886

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.12942501
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.33924090
3GBX2_23144817_ChIP-Seq_PC3_Human3.30284628
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.05504525
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.91534409
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.88845722
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.83919830
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.81240884
9REST_21632747_ChIP-Seq_MESCs_Mouse2.66832940
10PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.63590623
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.49767263
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.49767263
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.49231067
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.45837593
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.42734055
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.36748901
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.35842653
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.33759736
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.33489831
20SALL1_21062744_ChIP-ChIP_HESCs_Human2.33354127
21RARB_27405468_Chip-Seq_BRAIN_Mouse2.31016377
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.30723916
23CREB1_15753290_ChIP-ChIP_HEK293T_Human2.30006956
24EST1_17652178_ChIP-ChIP_JURKAT_Human2.21107977
25REST_18959480_ChIP-ChIP_MESCs_Mouse2.20613672
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.18309428
27MYC_18555785_ChIP-Seq_MESCs_Mouse2.16448412
28EZH2_27294783_Chip-Seq_ESCs_Mouse2.14923415
29SUZ12_27294783_Chip-Seq_ESCs_Mouse2.14868514
30EED_16625203_ChIP-ChIP_MESCs_Mouse2.12357836
31* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.12029325
32RNF2_27304074_Chip-Seq_ESCs_Mouse2.08236279
33NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.06577118
34* ETS1_20019798_ChIP-Seq_JURKAT_Human2.04111993
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.01086219
36ELK1_19687146_ChIP-ChIP_HELA_Human1.97366252
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.96305717
38MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.95269184
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.95258670
40FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.93777381
41DROSHA_22980978_ChIP-Seq_HELA_Human1.93558667
42THAP11_20581084_ChIP-Seq_MESCs_Mouse1.92444318
43TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.91362929
44ZNF274_21170338_ChIP-Seq_K562_Hela1.86485931
45CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.84016070
46VDR_23849224_ChIP-Seq_CD4+_Human1.83070382
47EWS_26573619_Chip-Seq_HEK293_Human1.81841423
48PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.78943354
49MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.75841907
50TAF15_26573619_Chip-Seq_HEK293_Human1.73338952
51AR_21572438_ChIP-Seq_LNCaP_Human1.69312633
52IKZF1_21737484_ChIP-ChIP_HCT116_Human1.68202787
53SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.67199673
54E2F4_17652178_ChIP-ChIP_JURKAT_Human1.65119308
55DCP1A_22483619_ChIP-Seq_HELA_Human1.59199173
56SMAD4_21799915_ChIP-Seq_A2780_Human1.59136703
57ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.57561604
58NR3C1_23031785_ChIP-Seq_PC12_Mouse1.57141002
59CTBP1_25329375_ChIP-Seq_LNCAP_Human1.57046066
60SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.55816771
61HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.55525973
62GABP_19822575_ChIP-Seq_HepG2_Human1.53114919
63* FLI1_27457419_Chip-Seq_LIVER_Mouse1.52344792
64CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.52069593
65PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.51535136
66SMAD_19615063_ChIP-ChIP_OVARY_Human1.50967281
67VDR_22108803_ChIP-Seq_LS180_Human1.44626570
68FOXP3_21729870_ChIP-Seq_TREG_Human1.43388338
69ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.39686866
70PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.39090181
71MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.38865301
72PADI4_21655091_ChIP-ChIP_MCF-7_Human1.38490800
73PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.38087915
74RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.37532827
75* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.37028442
76IGF1R_20145208_ChIP-Seq_DFB_Human1.36866469
77MYC_18940864_ChIP-ChIP_HL60_Human1.36452590
78MYC_18358816_ChIP-ChIP_MESCs_Mouse1.36236387
79MYCN_18555785_ChIP-Seq_MESCs_Mouse1.35843833
80ZFP57_27257070_Chip-Seq_ESCs_Mouse1.35761080
81POU3F2_20337985_ChIP-ChIP_501MEL_Human1.34684574
82SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32513243
83FUS_26573619_Chip-Seq_HEK293_Human1.32439585
84P300_19829295_ChIP-Seq_ESCs_Human1.32259785
85AR_25329375_ChIP-Seq_VCAP_Human1.32197398
86SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31487876
87GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.31177434
88E2F1_18555785_ChIP-Seq_MESCs_Mouse1.31172532
89TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29931306
90RING1B_27294783_Chip-Seq_ESCs_Mouse1.29921954
91EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29804668
92POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.28723564
93RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.28665147
94OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27240391
95MYC_19030024_ChIP-ChIP_MESCs_Mouse1.27164225
96CBX2_27304074_Chip-Seq_ESCs_Mouse1.26905383
97SOX2_21211035_ChIP-Seq_LN229_Gbm1.25581169
98ELF1_17652178_ChIP-ChIP_JURKAT_Human1.25471526
99TTF2_22483619_ChIP-Seq_HELA_Human1.25283381
100* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24728218
101ZFX_18555785_ChIP-Seq_MESCs_Mouse1.24704777
102MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.24323339
103IRF1_19129219_ChIP-ChIP_H3396_Human1.23504026
104GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22218684
105MYC_19079543_ChIP-ChIP_MESCs_Mouse1.21173561
106NELFA_20434984_ChIP-Seq_ESCs_Mouse1.20613836
107SRF_21415370_ChIP-Seq_HL-1_Mouse1.20169072
108* STAT3_23295773_ChIP-Seq_U87_Human1.19105052
109POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.19067606
110KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.18464685
111SMAD3_21741376_ChIP-Seq_EPCs_Human1.17489053
112KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17416612
113PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.16457407
114RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.16041148
115ERG_21242973_ChIP-ChIP_JURKAT_Human1.15792539
116CDX2_19796622_ChIP-Seq_MESCs_Mouse1.14576028
117YY1_21170310_ChIP-Seq_MESCs_Mouse1.12277230
118* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.12061463
119TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11042010
120PIAS1_25552417_ChIP-Seq_VCAP_Human1.10535777
121AR_19668381_ChIP-Seq_PC3_Human1.09967921
122POU5F1_16153702_ChIP-ChIP_HESCs_Human1.09378299
123TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.08994383
124CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.08138441
125CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.07971641
126TP53_22573176_ChIP-Seq_HFKS_Human1.07100333
127RBPJ_22232070_ChIP-Seq_NCS_Mouse1.06304480
128RNF2_27304074_Chip-Seq_NSC_Mouse1.06064470
129* TAL1_26923725_Chip-Seq_HPCs_Mouse1.05356060
130WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05285996
131HOXB4_20404135_ChIP-ChIP_EML_Mouse1.04743005
132YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04360407
133SOX2_16153702_ChIP-ChIP_HESCs_Human1.03762662
134NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02482590
135EP300_21415370_ChIP-Seq_HL-1_Mouse1.02320236
136JUN_21703547_ChIP-Seq_K562_Human1.01721978
137MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.01704562
138REST_19997604_ChIP-ChIP_NEURONS_Mouse1.01656816
139TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.00522033
140WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.00509996
141UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99971843
142GATA1_26923725_Chip-Seq_HPCs_Mouse0.99419384
143IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98470722
144CBP_20019798_ChIP-Seq_JUKART_Human0.98470722
145P53_22127205_ChIP-Seq_FIBROBLAST_Human0.98086063
146AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97662095
147TCF4_23295773_ChIP-Seq_U87_Human0.97523486
148SMAD3_21741376_ChIP-Seq_ESCs_Human0.96450799
149DNAJC2_21179169_ChIP-ChIP_NT2_Human0.96405956
150XRN2_22483619_ChIP-Seq_HELA_Human0.96131102
151PRDM14_20953172_ChIP-Seq_ESCs_Human0.95837769
152* NANOG_18555785_Chip-Seq_ESCs_Mouse0.94698269
153CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94070246
154MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94047865
155CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.93548480
156TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.92985196
157E2F1_21310950_ChIP-Seq_MCF-7_Human0.91566105
158NANOG_16153702_ChIP-ChIP_HESCs_Human0.91495675
159* RUNX2_22187159_ChIP-Seq_PCA_Human0.90711673
160TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90066848
161* PCGF2_27294783_Chip-Seq_NPCs_Mouse0.89616328
162MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.89339763
163* EZH2_27294783_Chip-Seq_NPCs_Mouse0.89092255
164EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.88967949
165RING1B_27294783_Chip-Seq_NPCs_Mouse0.88125731
166FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.87408582
167* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.87387856
168BCAT_22108803_ChIP-Seq_LS180_Human0.87201848
169FLI1_21867929_ChIP-Seq_TH2_Mouse0.87067756
170ZFP281_18757296_ChIP-ChIP_E14_Mouse0.85534382

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.47059155
2MP0003880_abnormal_central_pattern4.67307186
3MP0008877_abnormal_DNA_methylation3.94335173
4MP0004270_analgesia3.91868710
5MP0003635_abnormal_synaptic_transmissio3.63113827
6MP0005423_abnormal_somatic_nervous2.90576060
7MP0002063_abnormal_learning/memory/cond2.82330196
8MP0001968_abnormal_touch/_nociception2.79353608
9MP0009745_abnormal_behavioral_response2.72545166
10MP0002734_abnormal_mechanical_nocicepti2.61260088
11MP0008058_abnormal_DNA_repair2.60460595
12MP0002064_seizures2.57562041
13MP0009046_muscle_twitch2.40986939
14MP0002272_abnormal_nervous_system2.31445943
15MP0002736_abnormal_nociception_after2.31208174
16MP0002572_abnormal_emotion/affect_behav2.28335379
17MP0008995_early_reproductive_senescence2.22564429
18MP0003329_amyloid_beta_deposits2.22230109
19MP0001486_abnormal_startle_reflex2.17941403
20MP0002735_abnormal_chemical_nociception2.01784591
21MP0006276_abnormal_autonomic_nervous1.96255334
22MP0002733_abnormal_thermal_nociception1.95000168
23MP0003646_muscle_fatigue1.92315473
24MP0002067_abnormal_sensory_capabilities1.89560519
25MP0001970_abnormal_pain_threshold1.88809502
26MP0003123_paternal_imprinting1.83649174
27MP0001440_abnormal_grooming_behavior1.83240756
28MP0008569_lethality_at_weaning1.82515972
29MP0003121_genomic_imprinting1.80316809
30MP0002184_abnormal_innervation1.79507764
31MP0004215_abnormal_myocardial_fiber1.75699997
32MP0002210_abnormal_sex_determination1.75294770
33MP0001529_abnormal_vocalization1.75210454
34MP0002909_abnormal_adrenal_gland1.73412866
35MP0004145_abnormal_muscle_electrophysio1.71512569
36MP0000778_abnormal_nervous_system1.70776068
37MP0004924_abnormal_behavior1.69948470
38MP0005386_behavior/neurological_phenoty1.69948470
39MP0002160_abnormal_reproductive_system1.69922377
40MP0001501_abnormal_sleep_pattern1.68493466
41MP0001929_abnormal_gametogenesis1.68134631
42MP0006035_abnormal_mitochondrial_morpho1.64123084
43MP0001984_abnormal_olfaction1.63728483
44MP0000751_myopathy1.63408249
45MP0002837_dystrophic_cardiac_calcinosis1.63371737
46MP0004858_abnormal_nervous_system1.61404236
47MP0009780_abnormal_chondrocyte_physiolo1.58709250
48MP0000955_abnormal_spinal_cord1.58561772
49MP0004811_abnormal_neuron_physiology1.56202195
50MP0002557_abnormal_social/conspecific_i1.54259738
51MP0008789_abnormal_olfactory_epithelium1.53387814
52MP0006292_abnormal_olfactory_placode1.51687426
53MP0001502_abnormal_circadian_rhythm1.49987353
54MP0001905_abnormal_dopamine_level1.49878867
55MP0003786_premature_aging1.49674037
56MP0003186_abnormal_redox_activity1.47475903
57MP0006036_abnormal_mitochondrial_physio1.47117605
58MP0005646_abnormal_pituitary_gland1.44366643
59MP0003718_maternal_effect1.43234387
60MP0001145_abnormal_male_reproductive1.42871287
61MP0000013_abnormal_adipose_tissue1.42793705
62MP0002882_abnormal_neuron_morphology1.39565038
63MP0000653_abnormal_sex_gland1.39093208
64MP0002234_abnormal_pharynx_morphology1.34340359
65MP0008932_abnormal_embryonic_tissue1.32339089
66MP0002066_abnormal_motor_capabilities/c1.31136918
67MP0004885_abnormal_endolymph1.29509794
68MP0010094_abnormal_chromosome_stability1.24779532
69MP0002822_catalepsy1.24135362
70MP0002102_abnormal_ear_morphology1.23833756
71MP0003633_abnormal_nervous_system1.23312516
72MP0005645_abnormal_hypothalamus_physiol1.21968238
73MP0003879_abnormal_hair_cell1.21476755
74MP0005084_abnormal_gallbladder_morpholo1.21037848
75MP0006072_abnormal_retinal_apoptosis1.20584773
76MP0002653_abnormal_ependyma_morphology1.20220439
77MP0003122_maternal_imprinting1.18737248
78MP0002638_abnormal_pupillary_reflex1.17716324
79MP0003567_abnormal_fetal_cardiomyocyte1.16360455
80MP0005410_abnormal_fertilization1.15027861
81MP0005551_abnormal_eye_electrophysiolog1.13703331
82MP0002152_abnormal_brain_morphology1.10187407
83MP0003787_abnormal_imprinting1.10060677
84MP0004957_abnormal_blastocyst_morpholog1.09829156
85MP0004484_altered_response_of1.08609049
86MP0000358_abnormal_cell_content/1.07291778
87MP0003631_nervous_system_phenotype1.04781732
88MP0002229_neurodegeneration1.04572045
89MP0000049_abnormal_middle_ear1.04202350
90MP0010386_abnormal_urinary_bladder1.01078688
91MP0000372_irregular_coat_pigmentation1.01008825
92MP0000631_abnormal_neuroendocrine_gland1.00435687
93MP0004233_abnormal_muscle_weight1.00244681
94MP0009697_abnormal_copulation1.00051663
95MP0002161_abnormal_fertility/fecundity0.99522431
96MP0003119_abnormal_digestive_system0.99142484
97MP0003634_abnormal_glial_cell0.98090755
98MP0004036_abnormal_muscle_relaxation0.97551604
99MP0005367_renal/urinary_system_phenotyp0.97258889
100MP0000516_abnormal_urinary_system0.97258889
101MP0003111_abnormal_nucleus_morphology0.97106902
102MP0004085_abnormal_heartbeat0.95630330
103MP0004043_abnormal_pH_regulation0.94770016
104MP0002233_abnormal_nose_morphology0.92842666
105MP0008260_abnormal_autophagy0.92184390
106MP0004142_abnormal_muscle_tone0.91067630
107MP0005620_abnormal_muscle_contractility0.87189160
108MP0002752_abnormal_somatic_nervous0.86965802
109MP0001293_anophthalmia0.86928953
110MP0003077_abnormal_cell_cycle0.85375390
111MP0005389_reproductive_system_phenotype0.85206291
112MP0003137_abnormal_impulse_conducting0.84845545
113MP0005394_taste/olfaction_phenotype0.84547043
114MP0005499_abnormal_olfactory_system0.84547043
115MP0008007_abnormal_cellular_replicative0.84502539
116MP0000604_amyloidosis0.84055194
117MP0003136_yellow_coat_color0.82410080
118MP0005187_abnormal_penis_morphology0.81946418
119MP0001188_hyperpigmentation0.81853065
120MP0003890_abnormal_embryonic-extraembry0.81752398
121MP0005332_abnormal_amino_acid0.79755724
122MP0001963_abnormal_hearing_physiology0.78671796
123MP0002938_white_spotting0.78590391
124MP0004742_abnormal_vestibular_system0.77856404
125MP0001177_atelectasis0.77674591
126MP0002972_abnormal_cardiac_muscle0.77551567
127MP0001299_abnormal_eye_distance/0.76633909
128MP0003632_abnormal_nervous_system0.75016831
129MP0004084_abnormal_cardiac_muscle0.74988048
130MP0001485_abnormal_pinna_reflex0.73597027
131MP0003698_abnormal_male_reproductive0.72346430
132MP0000747_muscle_weakness0.71350278
133MP0005253_abnormal_eye_physiology0.71187993
134MP0002069_abnormal_eating/drinking_beha0.70976865
135MP0008872_abnormal_physiological_respon0.69614634
136MP0005535_abnormal_body_temperature0.68377484
137MP0000920_abnormal_myelination0.67678239
138MP0004147_increased_porphyrin_level0.66143939
139MP0003861_abnormal_nervous_system0.65425192
140MP0002090_abnormal_vision0.64459566
141MP0000749_muscle_degeneration0.64113473
142MP0002106_abnormal_muscle_physiology0.63448123
143MP0008961_abnormal_basal_metabolism0.61594611

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.89433285
2Myokymia (HP:0002411)5.18055357
3Visual hallucinations (HP:0002367)5.02030270
4Focal seizures (HP:0007359)4.25031192
5Epileptic encephalopathy (HP:0200134)4.00921808
6Atonic seizures (HP:0010819)3.63116669
7Progressive cerebellar ataxia (HP:0002073)3.48541900
8Ankle clonus (HP:0011448)3.42491055
9Supranuclear gaze palsy (HP:0000605)3.40503312
10Megalencephaly (HP:0001355)3.36236709
11Febrile seizures (HP:0002373)3.31584425
12Absence seizures (HP:0002121)3.27238669
13Nephrogenic diabetes insipidus (HP:0009806)3.20983432
14Hemiparesis (HP:0001269)3.20703206
15Depression (HP:0000716)3.15142643
16Generalized tonic-clonic seizures (HP:0002069)3.12891984
17Acute necrotizing encephalopathy (HP:0006965)3.10411396
18Medial flaring of the eyebrow (HP:0010747)3.10399339
19Action tremor (HP:0002345)3.07191217
20Gonadotropin excess (HP:0000837)3.05911483
21Abnormal mitochondria in muscle tissue (HP:0008316)3.05163691
22Hepatic necrosis (HP:0002605)3.01973859
23Neurofibrillary tangles (HP:0002185)2.92649306
24Hyperglycinemia (HP:0002154)2.90491570
25Progressive inability to walk (HP:0002505)2.88026774
26Renal cortical cysts (HP:0000803)2.87183081
27Truncal ataxia (HP:0002078)2.85625273
28Dialeptic seizures (HP:0011146)2.85586611
29Hepatocellular necrosis (HP:0001404)2.85019936
30Mitochondrial inheritance (HP:0001427)2.83664367
31Urinary urgency (HP:0000012)2.83417813
32Increased CSF lactate (HP:0002490)2.79503623
33Anxiety (HP:0000739)2.79430799
34Pheochromocytoma (HP:0002666)2.76930129
35Retinal dysplasia (HP:0007973)2.76865194
36Acute encephalopathy (HP:0006846)2.73130528
37Abnormality of the labia minora (HP:0012880)2.73095789
38Neuroendocrine neoplasm (HP:0100634)2.71581957
39Increased serum pyruvate (HP:0003542)2.70829444
40Broad-based gait (HP:0002136)2.67354551
41Progressive macrocephaly (HP:0004481)2.65824988
42Cerebral inclusion bodies (HP:0100314)2.63281110
43Impaired vibration sensation in the lower limbs (HP:0002166)2.61156967
44Type II lissencephaly (HP:0007260)2.58790024
45Poor eye contact (HP:0000817)2.57472335
46Decreased activity of mitochondrial respiratory chain (HP:0008972)2.55546575
47Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.55546575
48Tubulointerstitial nephritis (HP:0001970)2.54049013
49Generalized aminoaciduria (HP:0002909)2.53760096
50Spastic gait (HP:0002064)2.53497261
51Cerebral edema (HP:0002181)2.52611072
52Insidious onset (HP:0003587)2.51031021
53Termporal pattern (HP:0011008)2.51031021
54Proximal tubulopathy (HP:0000114)2.50669593
55Dysmetria (HP:0001310)2.50669207
56Dysdiadochokinesis (HP:0002075)2.47114557
57Mutism (HP:0002300)2.46816614
58Abnormality of serum amino acid levels (HP:0003112)2.43536648
59Abnormality of binocular vision (HP:0011514)2.41538703
60Diplopia (HP:0000651)2.41538703
61Genital tract atresia (HP:0001827)2.41163445
62Limb dystonia (HP:0002451)2.39766361
63Urinary bladder sphincter dysfunction (HP:0002839)2.38914786
64Vaginal atresia (HP:0000148)2.35598698
65Gaze-evoked nystagmus (HP:0000640)2.35165685
66Amblyopia (HP:0000646)2.34356190
67Abnormality of glycolysis (HP:0004366)2.31997766
68Methylmalonic acidemia (HP:0002912)2.30639267
69Increased serum lactate (HP:0002151)2.30440543
70Atrophy/Degeneration involving motor neurons (HP:0007373)2.30311318
71Scanning speech (HP:0002168)2.29498608
72Supernumerary spleens (HP:0009799)2.29297139
73Exercise-induced myalgia (HP:0003738)2.25548257
74Abnormal eating behavior (HP:0100738)2.25374545
75Increased intramyocellular lipid droplets (HP:0012240)2.24470769
76Postural instability (HP:0002172)2.22877573
77Renal Fanconi syndrome (HP:0001994)2.20386867
78Excessive salivation (HP:0003781)2.18434376
79Drooling (HP:0002307)2.18434376
80Lactic acidosis (HP:0003128)2.17204890
81Rimmed vacuoles (HP:0003805)2.17045682
82Absent speech (HP:0001344)2.14494147
83Hyperventilation (HP:0002883)2.14052488
84Lower limb muscle weakness (HP:0007340)2.13242220
85Abnormality of alanine metabolism (HP:0010916)2.12244486
86Hyperalaninemia (HP:0003348)2.12244486
87Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.12244486
88Central scotoma (HP:0000603)2.11544182
89Increased hepatocellular lipid droplets (HP:0006565)2.11076318
90Impaired social interactions (HP:0000735)2.10185423
91Abnormal social behavior (HP:0012433)2.10185423
92Gait imbalance (HP:0002141)2.09363152
93Papilledema (HP:0001085)2.08965938
94Microvesicular hepatic steatosis (HP:0001414)2.08752044
95Insomnia (HP:0100785)2.07992385
96Agitation (HP:0000713)2.06618358
97Oligodactyly (hands) (HP:0001180)2.06441558
98Ventricular fibrillation (HP:0001663)2.05760421
99Amyotrophic lateral sclerosis (HP:0007354)2.04611823
100Aplasia involving bones of the extremities (HP:0009825)2.03488367
101Aplasia involving bones of the upper limbs (HP:0009823)2.03488367
102Aplasia of the phalanges of the hand (HP:0009802)2.03488367
103Abnormality of glycine metabolism (HP:0010895)2.03084069
104Abnormality of serine family amino acid metabolism (HP:0010894)2.03084069
105Chromsome breakage (HP:0040012)2.03059785
106Abnormality of the corticospinal tract (HP:0002492)2.03043560
107Epileptiform EEG discharges (HP:0011182)2.02382306
108Poor coordination (HP:0002370)2.01946307
109EEG with generalized epileptiform discharges (HP:0011198)2.00513361
110Hemiplegia (HP:0002301)1.99700063
111Reticulocytopenia (HP:0001896)1.99124039
112Thickened helices (HP:0000391)1.97825309
113Polyphagia (HP:0002591)1.96861037
114Type I transferrin isoform profile (HP:0003642)1.96745555
115Poor suck (HP:0002033)1.96535320
116Torticollis (HP:0000473)1.95002338
117Abnormal protein glycosylation (HP:0012346)1.93787864
118Abnormal glycosylation (HP:0012345)1.93787864
119Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.93787864
120Abnormal protein N-linked glycosylation (HP:0012347)1.93787864
121Delusions (HP:0000746)1.93377452
122Fetal akinesia sequence (HP:0001989)1.93153107
1233-Methylglutaconic aciduria (HP:0003535)1.92669880
124Inability to walk (HP:0002540)1.92035526
125Failure to thrive in infancy (HP:0001531)1.91740798
126Short tibia (HP:0005736)1.90613029
127Bradykinesia (HP:0002067)1.89211278
128Colon cancer (HP:0003003)1.89201390
129Broad foot (HP:0001769)1.88558525
130Lissencephaly (HP:0001339)1.88557671
131Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.88308426
132Degeneration of the lateral corticospinal tracts (HP:0002314)1.88308426
133Abnormality of the lower motor neuron (HP:0002366)1.87457413
134Hypsarrhythmia (HP:0002521)1.86581956
135Prolonged QT interval (HP:0001657)1.86349629
136Exercise intolerance (HP:0003546)1.85905850
137Bundle branch block (HP:0011710)1.85245025
138Neoplasm of the peripheral nervous system (HP:0100007)1.83768281
139Split foot (HP:0001839)1.81924924
140Abnormal EKG (HP:0003115)1.80863166
141Degeneration of anterior horn cells (HP:0002398)1.80505939
142Abnormality of the anterior horn cell (HP:0006802)1.80505939
143Hypoplasia of the brainstem (HP:0002365)1.80373871
144Aplasia/Hypoplasia of the brainstem (HP:0007362)1.80373871
145Genetic anticipation (HP:0003743)1.80041655
146Gait ataxia (HP:0002066)1.77633574
147Impaired smooth pursuit (HP:0007772)1.77448966
148Psychosis (HP:0000709)1.77059731
149Focal dystonia (HP:0004373)1.77030785
150Decreased testicular size (HP:0008734)1.76494230
151Lipid accumulation in hepatocytes (HP:0006561)1.76165925
152Cerebral hypomyelination (HP:0006808)1.75939908
153Abnormality of the renal cortex (HP:0011035)1.75548368
154Hypoglycemic coma (HP:0001325)1.75417507
155Shoulder girdle muscle weakness (HP:0003547)1.75236170
156Thyroid-stimulating hormone excess (HP:0002925)1.74832090
157Specific learning disability (HP:0001328)1.74552017
158Congenital primary aphakia (HP:0007707)1.74514562
159Morphological abnormality of the pyramidal tract (HP:0002062)1.73899779
160Intention tremor (HP:0002080)1.73065999
161Unsteady gait (HP:0002317)1.73031603
162Syncope (HP:0001279)1.72444844
163Postaxial hand polydactyly (HP:0001162)1.72387960
164Median cleft lip (HP:0000161)1.72289614
165Stereotypic behavior (HP:0000733)1.71667457
166Hyperglycinuria (HP:0003108)1.71019057
167Clonus (HP:0002169)1.70919155
168Exercise-induced muscle cramps (HP:0003710)1.70699405
169Nephronophthisis (HP:0000090)1.69843550
170Intestinal atresia (HP:0011100)1.69745030
171Papillary thyroid carcinoma (HP:0002895)1.69612696
172Molar tooth sign on MRI (HP:0002419)1.68022089
173Abnormality of midbrain morphology (HP:0002418)1.68022089
174Metaphyseal dysplasia (HP:0100255)1.66186088
175CNS hypomyelination (HP:0003429)1.66107576
176CNS demyelination (HP:0007305)1.62830030
177X-linked dominant inheritance (HP:0001423)1.62583319
178Aplasia/Hypoplasia of the tibia (HP:0005772)1.61009103
179Stenosis of the external auditory canal (HP:0000402)1.60698986
180Increased muscle lipid content (HP:0009058)1.59280947
181Abnormality of renal resorption (HP:0011038)1.57197708
182Postaxial foot polydactyly (HP:0001830)1.56259205

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K93.90641783
2TRIM283.82941910
3EPHA43.49246244
4NTRK33.49197441
5KSR23.06016306
6BCR2.85792392
7MARK12.84222650
8MAP3K42.54053639
9PRKD32.52695230
10PLK42.48888350
11MINK12.47938183
12MAP3K122.46276061
13PAK62.28747178
14SRPK12.25572656
15MAP2K72.20862944
16NTRK22.15353860
17BCKDK2.12962499
18KSR12.10606057
19ARAF2.09759760
20MAP3K131.97845079
21CDK191.84353563
22MAP4K21.80744094
23TNIK1.72184232
24PHKG21.69491320
25PHKG11.69491320
26ERBB31.68799024
27MAPK131.64775818
28DAPK21.57376849
29MAP2K41.55693831
30NTRK11.52221274
31PBK1.50333000
32RAF11.49614055
33MUSK1.47896303
34CSNK1A1L1.46594410
35TESK21.44079012
36CSNK1G11.42858913
37MOS1.42004395
38CAMKK21.38352244
39EIF2AK11.37256842
40LMTK21.35952591
41PDK21.33394199
42CDK51.32660197
43RIPK41.31500485
44BMPR21.29570274
45PINK11.28735823
46EIF2AK31.27458823
47PDK31.27145083
48PDK41.27145083
49STK381.25504895
50PNCK1.23892166
51CAMKK11.19549411
52GRK51.16829686
53BRAF1.15547023
54LATS21.15090378
55ZAK1.09799576
56SGK4941.09243391
57SGK2231.09243391
58TYRO31.04373840
59PLK21.03970198
60PAK31.03571230
61RET1.01015401
62PLK11.00943971
63BUB11.00803013
64CAMK2A1.00784621
65TAOK10.97372107
66MAP3K20.96175895
67UHMK10.95938890
68EPHA30.95181924
69CDK140.94588359
70NEK10.93185228
71PTK2B0.93071599
72SCYL20.92802644
73MAPKAPK50.90935859
74MET0.90164072
75OBSCN0.88697836
76TTK0.88475087
77CDK180.88097190
78CDK150.86893614
79STK38L0.86687559
80DYRK20.86275515
81CSNK1G20.86217412
82SIK30.82836109
83CDC70.82334026
84MAP3K60.81597232
85DAPK10.81551416
86SGK20.81140942
87BRD40.80899121
88LIMK10.80198721
89MAP3K10.78098066
90CDK11A0.77953043
91PRKCG0.77871767
92DYRK1A0.75742392
93VRK10.74949878
94WNK30.72940728
95NUAK10.71669462
96STK240.69119611
97CAMK2B0.68699599
98DMPK0.68143938
99RPS6KA40.67256880
100MST40.67203560
101CAMK2D0.66320419
102CAMK10.65712073
103PLK30.62501722
104HIPK20.59874391
105CCNB10.58662607
106AKT30.57101112
107FLT30.56411600
108MAP2K10.56390611
109MAP3K50.54479366
110PKN10.54435614
111INSRR0.53746432
112STK30.53517272
113MKNK10.53300459
114CSNK1E0.53297875
115GRK10.53270878
116MARK20.52805039
117OXSR10.52185067
118AURKA0.51988196
119CAMK2G0.51440045
120SGK10.51347236
121STK110.51249150
122TESK10.50309237
123CDK30.48803601
124ROCK20.48363094
125RPS6KA50.48288936
126SGK30.47002316
127CASK0.46440227
128SIK20.46438357
129LATS10.45993592
130ATM0.43582764
131PDK10.43339467
132AURKB0.43215486
133BMPR1B0.43006828
134ATR0.42719552
135FES0.41431804
136CSNK2A20.40773041
137PIM20.40713579
138CSNK1G30.39094150
139CAMK1G0.36815322
140PRKCE0.36646740
141PDPK10.35906784
142PRPF4B0.35667387
143WNK40.35273069
144FER0.35261323
145PRKCH0.35102129
146STK160.34244093
147BRSK10.32561573
148RPS6KA30.31757542
149PRKCZ0.30769640
150ROCK10.29985333

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.17415092
2Synaptic vesicle cycle_Homo sapiens_hsa047212.85773973
3Long-term potentiation_Homo sapiens_hsa047202.63813485
4Protein export_Homo sapiens_hsa030602.57780973
5Circadian entrainment_Homo sapiens_hsa047132.49851570
6GABAergic synapse_Homo sapiens_hsa047272.49664134
7Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.44708356
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.43375848
9Glutamatergic synapse_Homo sapiens_hsa047242.42131714
10Mismatch repair_Homo sapiens_hsa034302.28923287
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.24560554
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.18798705
13Amphetamine addiction_Homo sapiens_hsa050312.17001358
14Morphine addiction_Homo sapiens_hsa050322.13292294
15Insulin secretion_Homo sapiens_hsa049112.13012056
16Propanoate metabolism_Homo sapiens_hsa006402.11343709
17Olfactory transduction_Homo sapiens_hsa047402.09448096
18Dopaminergic synapse_Homo sapiens_hsa047282.06448020
19Salivary secretion_Homo sapiens_hsa049702.06391251
20Ribosome_Homo sapiens_hsa030102.01094463
21Homologous recombination_Homo sapiens_hsa034402.00486550
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.98300024
23Base excision repair_Homo sapiens_hsa034101.94192527
24Gastric acid secretion_Homo sapiens_hsa049711.87701279
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.79766837
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.79647386
27Non-homologous end-joining_Homo sapiens_hsa034501.79378617
28Fatty acid elongation_Homo sapiens_hsa000621.79241602
29Long-term depression_Homo sapiens_hsa047301.78387519
30Cholinergic synapse_Homo sapiens_hsa047251.77121801
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.77072026
32Renin secretion_Homo sapiens_hsa049241.74312673
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.71224723
34Proteasome_Homo sapiens_hsa030501.69638937
35Serotonergic synapse_Homo sapiens_hsa047261.68649690
36Regulation of autophagy_Homo sapiens_hsa041401.65814058
37Fanconi anemia pathway_Homo sapiens_hsa034601.65779764
38Oxytocin signaling pathway_Homo sapiens_hsa049211.65096252
39Cardiac muscle contraction_Homo sapiens_hsa042601.63629070
40Nucleotide excision repair_Homo sapiens_hsa034201.63445341
41RNA transport_Homo sapiens_hsa030131.62159481
42Aldosterone synthesis and secretion_Homo sapiens_hsa049251.60120877
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.59928324
44Taste transduction_Homo sapiens_hsa047421.58499922
45Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.51536390
46Calcium signaling pathway_Homo sapiens_hsa040201.51284575
47DNA replication_Homo sapiens_hsa030301.50442957
48GnRH signaling pathway_Homo sapiens_hsa049121.47149071
49Gap junction_Homo sapiens_hsa045401.45907604
50Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.45521232
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.40729844
52Pyruvate metabolism_Homo sapiens_hsa006201.40520790
53Cocaine addiction_Homo sapiens_hsa050301.39759010
54Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.38151935
55Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.36560041
56Oocyte meiosis_Homo sapiens_hsa041141.35590794
57Collecting duct acid secretion_Homo sapiens_hsa049661.35547712
58RNA degradation_Homo sapiens_hsa030181.28773270
59RNA polymerase_Homo sapiens_hsa030201.28343067
60Basal transcription factors_Homo sapiens_hsa030221.28072039
61Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.27055380
62Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.25753506
63cAMP signaling pathway_Homo sapiens_hsa040241.24197479
64Carbon metabolism_Homo sapiens_hsa012001.22946795
65Butanoate metabolism_Homo sapiens_hsa006501.22460090
66Cysteine and methionine metabolism_Homo sapiens_hsa002701.18440134
67Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.17865296
68Peroxisome_Homo sapiens_hsa041461.17166011
69cGMP-PKG signaling pathway_Homo sapiens_hsa040221.16375583
70Purine metabolism_Homo sapiens_hsa002301.15109779
71Sulfur relay system_Homo sapiens_hsa041221.14425717
72Estrogen signaling pathway_Homo sapiens_hsa049151.13597113
73Pyrimidine metabolism_Homo sapiens_hsa002401.11160603
74Biosynthesis of amino acids_Homo sapiens_hsa012301.10123316
75Melanogenesis_Homo sapiens_hsa049161.09974571
76Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.07817726
77Vascular smooth muscle contraction_Homo sapiens_hsa042701.06551180
78Arginine and proline metabolism_Homo sapiens_hsa003301.05808152
79Spliceosome_Homo sapiens_hsa030401.05212178
80Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.04848932
81Steroid biosynthesis_Homo sapiens_hsa001001.04511389
82Circadian rhythm_Homo sapiens_hsa047101.03808881
83Pancreatic secretion_Homo sapiens_hsa049721.03054192
84Folate biosynthesis_Homo sapiens_hsa007901.03004159
85Vibrio cholerae infection_Homo sapiens_hsa051101.00876161
86Glioma_Homo sapiens_hsa052140.99050871
87Dorso-ventral axis formation_Homo sapiens_hsa043200.97539781
88Alzheimers disease_Homo sapiens_hsa050100.97343225
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.97228147
90Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.95264652
91Fatty acid metabolism_Homo sapiens_hsa012120.94474257
92Dilated cardiomyopathy_Homo sapiens_hsa054140.92283627
93Oxidative phosphorylation_Homo sapiens_hsa001900.91181064
94VEGF signaling pathway_Homo sapiens_hsa043700.90626738
95Parkinsons disease_Homo sapiens_hsa050120.88945597
96Vitamin B6 metabolism_Homo sapiens_hsa007500.88367067
97Axon guidance_Homo sapiens_hsa043600.86233847
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.85884110
99Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85517713
100Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.85499451
101Glucagon signaling pathway_Homo sapiens_hsa049220.84832460
102Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.84796868
103Type II diabetes mellitus_Homo sapiens_hsa049300.84156367
104Thyroid hormone synthesis_Homo sapiens_hsa049180.81818778
105Alcoholism_Homo sapiens_hsa050340.81486331
106Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.80632503
107Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.80466324
108ErbB signaling pathway_Homo sapiens_hsa040120.78646111
109Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77761866
110Metabolic pathways_Homo sapiens_hsa011000.77458588
111Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.77390763
112Glutathione metabolism_Homo sapiens_hsa004800.76426513
113Selenocompound metabolism_Homo sapiens_hsa004500.75680657
114Choline metabolism in cancer_Homo sapiens_hsa052310.75565486
115One carbon pool by folate_Homo sapiens_hsa006700.75167959
116Cell cycle_Homo sapiens_hsa041100.74489638
117beta-Alanine metabolism_Homo sapiens_hsa004100.73447253
118Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.72862400
119Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.72765758
120Ovarian steroidogenesis_Homo sapiens_hsa049130.71832732
121Fatty acid degradation_Homo sapiens_hsa000710.71826934
122Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71581683
123Huntingtons disease_Homo sapiens_hsa050160.71353119
124Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.70899615
125mRNA surveillance pathway_Homo sapiens_hsa030150.70081090
126Renal cell carcinoma_Homo sapiens_hsa052110.68347921
127Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67492078
128Sulfur metabolism_Homo sapiens_hsa009200.64294077
129Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63147273
130MAPK signaling pathway_Homo sapiens_hsa040100.61668402
131Sphingolipid signaling pathway_Homo sapiens_hsa040710.59318317
132Colorectal cancer_Homo sapiens_hsa052100.58222600
133Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56294033
134Endocytosis_Homo sapiens_hsa041440.56253439
135Neurotrophin signaling pathway_Homo sapiens_hsa047220.56074872
136mTOR signaling pathway_Homo sapiens_hsa041500.55234661
137Ras signaling pathway_Homo sapiens_hsa040140.55125999
138Wnt signaling pathway_Homo sapiens_hsa043100.54853709
139Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.54780332
140Inositol phosphate metabolism_Homo sapiens_hsa005620.54010526
141Arginine biosynthesis_Homo sapiens_hsa002200.53852942
142Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.53736401
143Phototransduction_Homo sapiens_hsa047440.53045149
144Endometrial cancer_Homo sapiens_hsa052130.52193629
145Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50904524
146Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50837264
147Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.50323486
148Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49163555
149Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47121577
150Insulin signaling pathway_Homo sapiens_hsa049100.46912787
151Rap1 signaling pathway_Homo sapiens_hsa040150.46595367
152Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44049464
153Non-small cell lung cancer_Homo sapiens_hsa052230.41904272
154Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.41856826
155Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40999186
156SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38758552
157Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38028772
158Central carbon metabolism in cancer_Homo sapiens_hsa052300.37507308
159Hedgehog signaling pathway_Homo sapiens_hsa043400.36785134
160Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36197494
161Primary bile acid biosynthesis_Homo sapiens_hsa001200.35833445
162Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.33874061
163Glycerophospholipid metabolism_Homo sapiens_hsa005640.31898631
164Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.31766585
165N-Glycan biosynthesis_Homo sapiens_hsa005100.30711668
166Pancreatic cancer_Homo sapiens_hsa052120.30467166
167Ether lipid metabolism_Homo sapiens_hsa005650.29676843
168Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.29563777

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »