MFAP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein with similarity to a bovine microfibril-associated protein. The protein has binding specificities for both collagen and carbohydrate. It is thought to be an extracellular matrix protein which is involved in cell adhesion or intercellular interactions. The gene is located within the Smith-Magenis syndrome region. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1respiratory tube development (GO:0030323)5.92144990
2protein heterotrimerization (GO:0070208)5.63002823
3bone trabecula formation (GO:0060346)5.43128910
4mesenchymal cell differentiation involved in kidney development (GO:0072161)5.32042957
5mesenchymal cell differentiation involved in renal system development (GO:2001012)5.32042957
6lung vasculature development (GO:0060426)5.24922120
7sequestering of extracellular ligand from receptor (GO:0035581)5.12763725
8collagen fibril organization (GO:0030199)4.83191544
9cell migration involved in heart development (GO:0060973)4.73913640
10neuron projection extension involved in neuron projection guidance (GO:1902284)4.59762925
11axon extension involved in axon guidance (GO:0048846)4.59762925
12regulation of endothelial cell differentiation (GO:0045601)4.56992987
13* extracellular matrix assembly (GO:0085029)4.47803002
14blood vessel maturation (GO:0001955)4.44741404
15negative regulation of chondrocyte differentiation (GO:0032331)4.39577218
16endocardial cushion development (GO:0003197)4.30353516
17adhesion of symbiont to host cell (GO:0044650)4.26225566
18virion attachment to host cell (GO:0019062)4.26225566
19peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)4.21826878
20glomerular filtration (GO:0003094)4.21113857
21negative regulation of catenin import into nucleus (GO:0035414)4.16570321
22cell differentiation involved in metanephros development (GO:0072202)4.12676735
23glomerulus development (GO:0032835)4.11257061
24type B pancreatic cell proliferation (GO:0044342)3.99181959
25positive regulation of endothelial cell differentiation (GO:0045603)3.90648670
26renal filtration (GO:0097205)3.83742080
27* extracellular fibril organization (GO:0043206)3.82287843
28endothelial cell proliferation (GO:0001935)3.77118830
29regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.75588825
30lung morphogenesis (GO:0060425)3.73916777
31collagen metabolic process (GO:0032963)3.72723712
32collagen catabolic process (GO:0030574)3.70936544
33regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.67549934
34negative regulation of cartilage development (GO:0061037)3.66134186
35cell proliferation involved in metanephros development (GO:0072203)3.64590843
36planar cell polarity pathway involved in neural tube closure (GO:0090179)3.64350748
37endocardial cushion morphogenesis (GO:0003203)3.62693059
38basement membrane organization (GO:0071711)3.59899091
39skin morphogenesis (GO:0043589)3.59229986
40adhesion of symbiont to host (GO:0044406)3.59071904
41head development (GO:0060322)3.57069261
42multicellular organismal macromolecule metabolic process (GO:0044259)3.56250094
43cellular response to BMP stimulus (GO:0071773)3.56156921
44response to BMP (GO:0071772)3.56156921
45epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.55548619
46artery development (GO:0060840)3.53174909
47mesenchyme morphogenesis (GO:0072132)3.49869541
48glomerular basement membrane development (GO:0032836)3.49779349
49multicellular organismal catabolic process (GO:0044243)3.48139811
50chondrocyte proliferation (GO:0035988)3.46753166
51regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.43856490
52metanephric mesenchyme development (GO:0072075)3.43439959
53polarized epithelial cell differentiation (GO:0030859)3.42934514
54endothelial tube morphogenesis (GO:0061154)3.41627219
55morphogenesis of an endothelium (GO:0003159)3.41627219
56lymphangiogenesis (GO:0001946)3.41486317
57anatomical structure regression (GO:0060033)3.40214635
58mesenchymal-epithelial cell signaling (GO:0060638)3.40126406
59regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.39587649
60diaphragm development (GO:0060539)3.39308534
61lymph vessel development (GO:0001945)3.38859007
62surfactant homeostasis (GO:0043129)3.38514043
63keratan sulfate catabolic process (GO:0042340)3.36560582
64multicellular organismal metabolic process (GO:0044236)3.35516530
65dermatan sulfate metabolic process (GO:0030205)3.35444722
66regulation of chondrocyte differentiation (GO:0032330)3.34144826
67tooth mineralization (GO:0034505)3.33923909
68cartilage morphogenesis (GO:0060536)3.33597529
69negative regulation of smooth muscle cell migration (GO:0014912)3.32903768
70regulation of tight junction assembly (GO:2000810)3.26821130
71cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.24106156
72endodermal cell differentiation (GO:0035987)3.22768203
73craniofacial suture morphogenesis (GO:0097094)3.22138821
74skeletal muscle organ development (GO:0060538)3.21247791
75kidney mesenchyme development (GO:0072074)3.20931539
76cell proliferation involved in kidney development (GO:0072111)3.18803141
77mesonephric tubule development (GO:0072164)3.17164201
78smooth muscle tissue development (GO:0048745)3.16068686
79regulation of cartilage development (GO:0061035)3.15490290
80positive regulation of gastrulation (GO:2000543)3.15191971
81ureteric bud development (GO:0001657)3.14378233
82* fibril organization (GO:0097435)3.13718788
83dermatan sulfate biosynthetic process (GO:0030208)3.13435895
84organ formation (GO:0048645)3.13061753
85mesonephric epithelium development (GO:0072163)3.10938884
86extracellular matrix disassembly (GO:0022617)3.10385523
87lateral sprouting from an epithelium (GO:0060601)3.10262976
88midgut development (GO:0007494)3.08387816
89blood vessel remodeling (GO:0001974)3.07717426
90vasculature development (GO:0001944)3.07429637
91extracellular negative regulation of signal transduction (GO:1900116)3.07040219
92extracellular regulation of signal transduction (GO:1900115)3.07040219
93embryonic digestive tract morphogenesis (GO:0048557)3.05757243
94regulation of extracellular matrix disassembly (GO:0010715)3.04827217
95outer ear morphogenesis (GO:0042473)3.04343011
96apoptotic cell clearance (GO:0043277)3.03015323
97endothelial cell morphogenesis (GO:0001886)3.02312642
98negative regulation of androgen receptor signaling pathway (GO:0060766)3.00426585
99positive regulation of endothelial cell apoptotic process (GO:2000353)2.97349073
100paraxial mesoderm development (GO:0048339)2.96973358
101lung lobe morphogenesis (GO:0060463)2.93560598
102negative regulation of embryonic development (GO:0045992)2.93381709
103regulation of non-canonical Wnt signaling pathway (GO:2000050)2.92597375
104mesenchyme development (GO:0060485)2.92350396
105negative regulation of axon extension involved in axon guidance (GO:0048843)2.90922947
106barbed-end actin filament capping (GO:0051016)2.90006819
107* extracellular matrix organization (GO:0030198)2.89434394
108middle ear morphogenesis (GO:0042474)2.89091327
109cellular response to vitamin (GO:0071295)2.88908418
110* extracellular structure organization (GO:0043062)2.88267309
111retina vasculature morphogenesis in camera-type eye (GO:0061299)2.88142308
112mesenchymal cell proliferation (GO:0010463)2.86378541
113positive regulation of mesenchymal cell proliferation (GO:0002053)2.85119454
114tonic smooth muscle contraction (GO:0014820)2.84661272
115cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.84470946
116negative regulation of stem cell proliferation (GO:2000647)2.82671344
117negative regulation of heart growth (GO:0061117)2.81648870
118negative regulation of cardiac muscle tissue growth (GO:0055022)2.81648870
119regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.81432352
120atrioventricular valve morphogenesis (GO:0003181)2.81057466
121vascular endothelial growth factor signaling pathway (GO:0038084)2.80831517
122positive regulation of Rho protein signal transduction (GO:0035025)2.80488142
123regulation of heart morphogenesis (GO:2000826)2.79914730
124regulation of integrin-mediated signaling pathway (GO:2001044)2.76221210
125growth hormone secretion (GO:0030252)2.74063067
126negative regulation of BMP signaling pathway (GO:0030514)2.72811557
127negative regulation of leukocyte chemotaxis (GO:0002689)2.69638423
128venous blood vessel morphogenesis (GO:0048845)2.65812106
129protein localization to cell surface (GO:0034394)2.63615359
130positive regulation of receptor recycling (GO:0001921)2.57830451
131complement activation, classical pathway (GO:0006958)2.57606202
132positive regulation of pseudopodium assembly (GO:0031274)2.53044556
133endocrine hormone secretion (GO:0060986)2.52206005
134negative regulation of complement activation (GO:0045916)2.52046898
135regulation of gastrulation (GO:0010470)2.51754951
136glycosaminoglycan catabolic process (GO:0006027)2.51562857
137trabecula formation (GO:0060343)2.50929403
138chemical homeostasis within a tissue (GO:0048875)2.49851136
139chondroitin sulfate catabolic process (GO:0030207)2.48731190
140cardiac myofibril assembly (GO:0055003)2.48691186
141response to fluid shear stress (GO:0034405)2.48287789
142regulation of pseudopodium assembly (GO:0031272)2.42310405
143regulation of cardioblast differentiation (GO:0051890)2.41927054
144negative regulation of fatty acid transport (GO:2000192)2.39209420
145stress fiber assembly (GO:0043149)2.39008331
146ethanol oxidation (GO:0006069)2.36983774
147cGMP-mediated signaling (GO:0019934)2.35577604
148Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.35350880
149regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.33631035
150substrate adhesion-dependent cell spreading (GO:0034446)2.33429393
151embryonic skeletal joint morphogenesis (GO:0060272)2.32673135
152artery morphogenesis (GO:0048844)2.32430125

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human5.08904010
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.13101511
3PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse4.09051816
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.68191623
5RBPJ_22232070_ChIP-Seq_NCS_Mouse3.53014164
6RARG_19884340_ChIP-ChIP_MEFs_Mouse3.16623843
7EED_16625203_ChIP-ChIP_MESCs_Mouse3.12125870
8ESR1_22446102_ChIP-Seq_UTERUS_Mouse3.07887317
9GATA1_22025678_ChIP-Seq_K562_Human2.81052740
10CLOCK_20551151_ChIP-Seq_293T_Human2.80067250
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.55848984
12EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.52907093
13EP300_21415370_ChIP-Seq_HL-1_Mouse2.48845325
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.48240274
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.48240274
16PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.45499063
17WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.44053670
18* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.43181008
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.39147427
20CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.32498517
21STAT6_21828071_ChIP-Seq_BEAS2B_Human2.23691280
22RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.18666229
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.14177409
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.10710999
25SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.02511935
26CDX2_19796622_ChIP-Seq_MESCs_Mouse2.01369075
27CJUN_26792858_Chip-Seq_BT549_Human1.94535563
28JARID2_20075857_ChIP-Seq_MESCs_Mouse1.92335520
29ISL1_27105846_Chip-Seq_CPCs_Mouse1.91115655
30TP63_19390658_ChIP-ChIP_HaCaT_Human1.90068331
31WT1_19549856_ChIP-ChIP_CCG9911_Human1.89711321
32TP53_20018659_ChIP-ChIP_R1E_Mouse1.88482155
33TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.87272210
34EZH2_27304074_Chip-Seq_ESCs_Mouse1.86305127
35SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.78564293
36CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.76086411
37BRD4_25478319_ChIP-Seq_HGPS_Human1.75344174
38RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.73705364
39CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.64911069
40MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.54460739
41RNF2_27304074_Chip-Seq_ESCs_Mouse1.52261759
42JARID2_20064375_ChIP-Seq_MESCs_Mouse1.51060611
43ZFP281_18757296_ChIP-ChIP_E14_Mouse1.51053925
44MTF2_20144788_ChIP-Seq_MESCs_Mouse1.50214878
45BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.45632722
46EZH2_22144423_ChIP-Seq_EOC_Human1.45158685
47ELK3_25401928_ChIP-Seq_HUVEC_Human1.44732303
48ESR1_21235772_ChIP-Seq_MCF-7_Human1.43888662
49TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42921708
50CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.41711855
51* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.41068242
52NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.39447594
53ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.35039931
54IKZF1_21737484_ChIP-ChIP_HCT116_Human1.34632178
55ESR2_21235772_ChIP-Seq_MCF-7_Human1.30873829
56BCAT_22108803_ChIP-Seq_LS180_Human1.29332435
57NFIB_24661679_ChIP-Seq_LUNG_Mouse1.29025277
58ZNF217_24962896_ChIP-Seq_MCF-7_Human1.27893919
59ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.27467936
60NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.26433602
61SMAD_19615063_ChIP-ChIP_OVARY_Human1.24329367
62WT1_25993318_ChIP-Seq_PODOCYTE_Human1.23876354
63NRF2_20460467_ChIP-Seq_MEFs_Mouse1.21964950
64NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.21964950
65ESR1_20079471_ChIP-ChIP_T-47D_Human1.20816819
66AR_21572438_ChIP-Seq_LNCaP_Human1.19629954
67RING1B_27294783_Chip-Seq_ESCs_Mouse1.18716307
68TBX20_22080862_ChIP-Seq_HEART_Mouse1.18562597
69TBX20_22328084_ChIP-Seq_HEART_Mouse1.18562597
70TP53_18474530_ChIP-ChIP_U2OS_Human1.17563138
71ZFP281_27345836_Chip-Seq_ESCs_Mouse1.16134381
72RING1B_27294783_Chip-Seq_NPCs_Mouse1.16059735
73GATA2_21666600_ChIP-Seq_HMVEC_Human1.15863366
74EZH2_27294783_Chip-Seq_ESCs_Mouse1.15761156
75PPAR_26484153_Chip-Seq_NCI-H1993_Human1.12939645
76KDM2B_26808549_Chip-Seq_SUP-B15_Human1.12129174
77SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.12011111
78PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.09628869
79RXR_22158963_ChIP-Seq_LIVER_Mouse1.08899727
80RAD21_21589869_ChIP-Seq_MESCs_Mouse1.08826305
81SMC1_22415368_ChIP-Seq_MEFs_Mouse1.07709741
82PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.07612298
83PIAS1_25552417_ChIP-Seq_VCAP_Human1.06885232
84POU5F1_16153702_ChIP-ChIP_HESCs_Human1.05500621
85TP63_17297297_ChIP-ChIP_HaCaT_Human1.05093251
86HIF1A_21447827_ChIP-Seq_MCF-7_Human1.04853375
87LXR_22158963_ChIP-Seq_LIVER_Mouse1.04703107
88CBX2_27304074_Chip-Seq_ESCs_Mouse1.03884429
89SALL4_18804426_ChIP-ChIP_XEN_Mouse1.03239750
90TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.02672174
91TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.01899603
92PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.01760881
93SUZ12_27294783_Chip-Seq_ESCs_Mouse1.01540897
94UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.01073401
95P300_27058665_Chip-Seq_ZR-75-30cells_Human1.00918267
96SOX9_24532713_ChIP-Seq_HFSC_Mouse0.99275892
97KDM2B_26808549_Chip-Seq_K562_Human0.97619566
98SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.97217475
99DROSHA_22980978_ChIP-Seq_HELA_Human0.95678550
100CDX2_20551321_ChIP-Seq_CACO-2_Human0.95214795
101DNAJC2_21179169_ChIP-ChIP_NT2_Human0.92324370
102FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.91511735
103EGR1_19374776_ChIP-ChIP_THP-1_Human0.90977039
104SA1_22415368_ChIP-Seq_MEFs_Mouse0.90721505
105CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.90201625
106TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.89122139
107SOX2_20726797_ChIP-Seq_SW620_Human0.88328617
108NR3C1_23031785_ChIP-Seq_PC12_Mouse0.88037586
109SALL1_21062744_ChIP-ChIP_HESCs_Human0.87915651
110HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.87521548
111JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86914649
112NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.86892828
113PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.86865605
114LXR_22292898_ChIP-Seq_THP-1_Human0.86080518
115SMAD3_21741376_ChIP-Seq_HESCs_Human0.85646940
116SMC3_22415368_ChIP-Seq_MEFs_Mouse0.85578267
117TP53_16413492_ChIP-PET_HCT116_Human0.83787676
118PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.83408967
119* TP53_23651856_ChIP-Seq_MEFs_Mouse0.82598045
120RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.81989391
121ERG_21242973_ChIP-ChIP_JURKAT_Human0.81927735
122* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.81701761
123STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.81027568

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen7.29374326
2MP0005503_abnormal_tendon_morphology6.06466484
3MP0005275_abnormal_skin_tensile4.89307260
4MP0001958_emphysema3.77955174
5MP0004272_abnormal_basement_membrane3.02709702
6MP0010368_abnormal_lymphatic_system2.71003385
7MP0003115_abnormal_respiratory_system2.65076411
8MP0005508_abnormal_skeleton_morphology2.64939832
9MP0002249_abnormal_larynx_morphology2.58317624
10MP0003279_aneurysm2.56066018
11MP0006054_spinal_hemorrhage2.53972289
12MP0003705_abnormal_hypodermis_morpholog2.45586578
13MP0009250_abnormal_appendicular_skeleto2.41423243
14MP0002282_abnormal_trachea_morphology2.34062794
15MP0003385_abnormal_body_wall2.31181316
16MP0000537_abnormal_urethra_morphology2.17456453
17MP0001879_abnormal_lymphatic_vessel2.02184559
18MP0002108_abnormal_muscle_morphology1.99683070
19MP0000534_abnormal_ureter_morphology1.98815223
20MP0010030_abnormal_orbit_morphology1.92795632
21MP0000049_abnormal_middle_ear1.89320067
22MP0009384_cardiac_valve_regurgitation1.83198125
23MP0003122_maternal_imprinting1.78637099
24MP0003942_abnormal_urinary_system1.78359719
25MP0000516_abnormal_urinary_system1.62612819
26MP0005367_renal/urinary_system_phenotyp1.62612819
27MP0005257_abnormal_intraocular_pressure1.62050848
28MP0008004_abnormal_stomach_pH1.58231459
29MP0005670_abnormal_white_adipose1.54055178
30MP0009053_abnormal_anal_canal1.53227076
31MP0005623_abnormal_meninges_morphology1.50930824
32MP0000767_abnormal_smooth_muscle1.47682465
33MP0003566_abnormal_cell_adhesion1.47647395
34MP0002932_abnormal_joint_morphology1.46196416
35MP0002938_white_spotting1.43540244
36MP0000428_abnormal_craniofacial_morphol1.41987842
37MP0002295_abnormal_pulmonary_circulatio1.41946793
38MP0002060_abnormal_skin_morphology1.36021442
39MP0001175_abnormal_lung_morphology1.34469608
40MP0003935_abnormal_craniofacial_develop1.33353681
41MP0000751_myopathy1.32170501
42MP0000733_abnormal_muscle_development1.28153570
43MP0000163_abnormal_cartilage_morphology1.27277223
44MP0002933_joint_inflammation1.26692239
45MP0002132_abnormal_respiratory_system1.21290997
46MP0005390_skeleton_phenotype1.20985214
47MP0000013_abnormal_adipose_tissue1.19576455
48MP0003755_abnormal_palate_morphology1.17906589
49MP0004134_abnormal_chest_morphology1.17402599
50MP0006138_congestive_heart_failure1.15138544
51MP0004858_abnormal_nervous_system1.13881452
52MP0003119_abnormal_digestive_system1.11816598
53MP0003937_abnormal_limbs/digits/tail_de1.11761714
54MP0002115_abnormal_skeleton_extremities1.11278690
55MP0000762_abnormal_tongue_morphology1.08035029
56MP0005023_abnormal_wound_healing1.07959747
57MP0000462_abnormal_digestive_system1.05516896
58MP0001542_abnormal_bone_strength1.04847397
59MP0005388_respiratory_system_phenotype1.04600579
60MP0002133_abnormal_respiratory_system1.04600579
61MP0002896_abnormal_bone_mineralization1.01356342
62MP0001243_abnormal_dermal_layer1.01272250
63MP0002116_abnormal_craniofacial_bone1.00441060
64MP0002109_abnormal_limb_morphology0.99835157
65MP0001177_atelectasis0.99469098
66MP0002128_abnormal_blood_circulation0.96625993
67MP0005164_abnormal_response_to0.96203352
68MP0002113_abnormal_skeleton_development0.94949740
69MP0000566_synostosis0.94592964
70MP0002168_other_aberrant_phenotype0.94346486
71MP0001270_distended_abdomen0.94251318
72MP0005248_abnormal_Harderian_gland0.92612135
73MP0000432_abnormal_head_morphology0.91998657
74MP0004782_abnormal_surfactant_physiolog0.91276894
75MP0003091_abnormal_cell_migration0.87029993
76MP0003045_fibrosis0.86832395
77MP0002925_abnormal_cardiovascular_devel0.85919315
78MP0003123_paternal_imprinting0.85150198
79MP0002233_abnormal_nose_morphology0.84389723
80MP0002396_abnormal_hematopoietic_system0.83018764
81MP0002254_reproductive_system_inflammat0.82095210
82MP0001614_abnormal_blood_vessel0.81660738
83MP0002111_abnormal_tail_morphology0.81373727
84MP0005409_darkened_coat_color0.81026991
85MP0001299_abnormal_eye_distance/0.80716570
86MP0003011_delayed_dark_adaptation0.80629900
87MP0003315_abnormal_perineum_morphology0.79889544
88MP0000759_abnormal_skeletal_muscle0.79245964
89MP0002114_abnormal_axial_skeleton0.78851494
90MP0005595_abnormal_vascular_smooth0.78025426
91MP0003567_abnormal_fetal_cardiomyocyte0.75641875
92MP0005171_absent_coat_pigmentation0.75555591
93MP0002971_abnormal_brown_adipose0.75313524
94MP0003724_increased_susceptibility_to0.75183432
95MP0001849_ear_inflammation0.75026736
96MP0003828_pulmonary_edema0.73953112
97MP0010386_abnormal_urinary_bladder0.73779476
98MP0005167_abnormal_blood-brain_barrier0.73672780
99MP0000678_abnormal_parathyroid_gland0.72102904
100MP0005385_cardiovascular_system_phenoty0.71927974
101MP0001544_abnormal_cardiovascular_syste0.71927974
102MP0003941_abnormal_skin_development0.71034079
103MP0002127_abnormal_cardiovascular_syste0.69348659
104MP0004084_abnormal_cardiac_muscle0.68878548
105MP0004883_abnormal_blood_vessel0.68452721
106MP0002697_abnormal_eye_size0.66616036
107MP0000003_abnormal_adipose_tissue0.66583248
108MP0003283_abnormal_digestive_organ0.66549927
109MP0000249_abnormal_blood_vessel0.65514830
110MP0005375_adipose_tissue_phenotype0.65219749
111MP0000266_abnormal_heart_morphology0.65182612
112MP0000538_abnormal_urinary_bladder0.64620499
113MP0003448_altered_tumor_morphology0.63618417
114MP0004133_heterotaxia0.63294001
115MP0001533_abnormal_skeleton_physiology0.63147230
116MP0003795_abnormal_bone_structure0.63055391
117MP0005666_abnormal_adipose_tissue0.62915857
118MP0002998_abnormal_bone_remodeling0.62902269
119MP0000343_altered_response_to0.62486314
120MP0004484_altered_response_of0.62465303
121MP0005330_cardiomyopathy0.61713386
122MP0003950_abnormal_plasma_membrane0.61255482
123MP0005369_muscle_phenotype0.60493853
124MP0009780_abnormal_chondrocyte_physiolo0.60064674
125MP0000749_muscle_degeneration0.60063461
126MP0000681_abnormal_thyroid_gland0.59108387
127MP0004036_abnormal_muscle_relaxation0.58704138
128MP0005620_abnormal_muscle_contractility0.58650050
129MP0005058_abnormal_lysosome_morphology0.58522029
130MP0003300_gastrointestinal_ulcer0.58508326
131MP0004087_abnormal_muscle_fiber0.58015466
132MP0001664_abnormal_digestion0.57120721
133MP0010352_gastrointestinal_tract_polyps0.57064544
134MP0000230_abnormal_systemic_arterial0.54793403

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)6.45126294
2Premature rupture of membranes (HP:0001788)5.41079803
3Broad metatarsal (HP:0001783)4.96354471
4Ankle contracture (HP:0006466)4.79973824
5Shallow orbits (HP:0000586)4.67467823
6Aortic dissection (HP:0002647)4.50674829
7Bladder diverticulum (HP:0000015)4.48792819
8Short 4th metacarpal (HP:0010044)3.90228045
9Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.90228045
10Bell-shaped thorax (HP:0001591)3.81335916
11Spinal rigidity (HP:0003306)3.75875782
12Increased variability in muscle fiber diameter (HP:0003557)3.71637481
13Aortic aneurysm (HP:0004942)3.64422538
14Soft skin (HP:0000977)3.57777026
15Type 1 muscle fiber predominance (HP:0003803)3.53397412
16Cerebral aneurysm (HP:0004944)3.53387615
17Follicular hyperkeratosis (HP:0007502)3.51169427
18Pulmonary artery stenosis (HP:0004415)3.50955386
19Renal duplication (HP:0000075)3.39106333
20Atrophic scars (HP:0001075)3.25787912
21Mitral valve prolapse (HP:0001634)3.22657371
22Flat cornea (HP:0007720)3.18068219
23Abnormality of skeletal muscle fiber size (HP:0012084)3.15968865
24Abnormality of the 4th metacarpal (HP:0010012)3.12096230
25Back pain (HP:0003418)3.10170907
26Systemic lupus erythematosus (HP:0002725)3.03630067
27Slender build (HP:0001533)3.02099218
28Renovascular hypertension (HP:0100817)2.96111748
29Midline defect of the nose (HP:0004122)2.94692315
30Dilatation of the ascending aorta (HP:0005111)2.81255263
31Camptodactyly of toe (HP:0001836)2.80923244
32Fragile skin (HP:0001030)2.80435617
33Wrist flexion contracture (HP:0001239)2.75339412
34Blue sclerae (HP:0000592)2.75045668
35Lymphangioma (HP:0100764)2.65197960
36Abnormality of complement system (HP:0005339)2.65172916
37Bowel diverticulosis (HP:0005222)2.63460219
38Tracheomalacia (HP:0002779)2.59198284
39Hyperextensible skin (HP:0000974)2.56644882
40Neonatal short-limb short stature (HP:0008921)2.56391557
41Disproportionate tall stature (HP:0001519)2.56241376
42Complement deficiency (HP:0004431)2.50397667
43Wide anterior fontanel (HP:0000260)2.50046027
44Redundant skin (HP:0001582)2.50015337
45Abnormality of dentin (HP:0010299)2.48311884
46Peritonitis (HP:0002586)2.45113561
47Hyperacusis (HP:0010780)2.42540615
48Wormian bones (HP:0002645)2.41959512
49Joint stiffness (HP:0001387)2.37814451
50Abnormal delivery (HP:0001787)2.37680258
51Joint laxity (HP:0001388)2.32446146
52Abnormality of the lumbar spine (HP:0100712)2.32374862
53Deviation of the hallux (HP:0010051)2.31131406
54Emphysema (HP:0002097)2.30627437
55Vertebral compression fractures (HP:0002953)2.29777147
56Elfin facies (HP:0004428)2.28739285
57Biconcave vertebral bodies (HP:0004586)2.28437223
58Missing ribs (HP:0000921)2.27265968
59Overriding aorta (HP:0002623)2.26090442
60Turricephaly (HP:0000262)2.25635366
61Striae distensae (HP:0001065)2.24246424
62Ectopia lentis (HP:0001083)2.23787003
63Abnormality of the acetabulum (HP:0003170)2.23034374
64Hallux valgus (HP:0001822)2.22772437
65Broad ribs (HP:0000885)2.22656239
66Breech presentation (HP:0001623)2.20575835
67Asymmetry of the thorax (HP:0001555)2.20315929
68Mildly elevated creatine phosphokinase (HP:0008180)2.20313078
69Vascular tortuosity (HP:0004948)2.19949604
70Microglossia (HP:0000171)2.18981902
71Osteolytic defects of the phalanges of the hand (HP:0009771)2.16984835
72Osteolytic defects of the hand bones (HP:0009699)2.16984835
73Mild short stature (HP:0003502)2.16217096
74Genu recurvatum (HP:0002816)2.15718398
75Joint contractures involving the joints of the feet (HP:0100492)2.15495261
76Flexion contracture of toe (HP:0005830)2.15495261
77Hematochezia (HP:0002573)2.13918614
78Mitral regurgitation (HP:0001653)2.13811468
79Aneurysm (HP:0002617)2.12952171
80Infantile muscular hypotonia (HP:0008947)2.09170527
81Narrow nasal bridge (HP:0000446)2.08869787
82Delayed cranial suture closure (HP:0000270)2.08649706
83Inguinal hernia (HP:0000023)2.08304200
84Myelomeningocele (HP:0002475)2.07042733
85Subacute progressive viral hepatitis (HP:0006572)2.06402870
86Increased connective tissue (HP:0009025)2.06195760
87Cervical subluxation (HP:0003308)2.02782097
88Mesomelia (HP:0003027)2.02347399
89Premature skin wrinkling (HP:0100678)2.01938967
90Long toe (HP:0010511)2.01183889
91Elbow flexion contracture (HP:0002987)1.99786442
92Spondylolisthesis (HP:0003302)1.99297709
93Persistence of primary teeth (HP:0006335)1.98059384
94Abnormal umbilical cord blood vessels (HP:0011403)1.98049620
95Single umbilical artery (HP:0001195)1.98049620
96Abnormality of the fetal cardiovascular system (HP:0010948)1.98049620
97Abnormality of the diencephalon (HP:0010662)1.97696860
98Aortic regurgitation (HP:0001659)1.96989560
99Coronal craniosynostosis (HP:0004440)1.96598070
100Scapular winging (HP:0003691)1.95577482
101Limited hip movement (HP:0008800)1.95402458
102Rectal prolapse (HP:0002035)1.95236721
103Patent foramen ovale (HP:0001655)1.94853394
104Hepatoblastoma (HP:0002884)1.94081258
105Generalized amyotrophy (HP:0003700)1.93889724
106Broad long bones (HP:0005622)1.92840512
107Arterial tortuosity (HP:0005116)1.91420080
108Gingival overgrowth (HP:0000212)1.90919010
109Osteoarthritis (HP:0002758)1.90142785
110Aortic valve stenosis (HP:0001650)1.89436426
111Ovoid vertebral bodies (HP:0003300)1.89218800
112Thin bony cortex (HP:0002753)1.88796014
113Osteopenia (HP:0000938)1.86682917
114Enlarged kidneys (HP:0000105)1.84887720
115Overgrowth (HP:0001548)1.84599086
116Delayed closure of the anterior fontanelle (HP:0001476)1.82360582
117Protruding ear (HP:0000411)1.82207046
118Flared iliac wings (HP:0002869)1.81095920
119Hypoventilation (HP:0002791)1.80851543
120Hip contracture (HP:0003273)1.80826632
121Round ear (HP:0100830)1.80477115
122Nonimmune hydrops fetalis (HP:0001790)1.80041473
123Ulnar deviation of the wrist (HP:0003049)1.76193532
124Venous abnormality (HP:0002624)1.75104419
125Abnormality of skull ossification (HP:0002703)1.71260317
126Thin skin (HP:0000963)1.70230375
127Arachnodactyly (HP:0001166)1.68516630
128Tarsal synostosis (HP:0008368)1.64892412
129Interstitial pulmonary disease (HP:0006530)1.64887718
130Venous insufficiency (HP:0005293)1.64744569

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA34.33112208
2LATS23.87876810
3TGFBR23.82332666
4DDR23.33059303
5MYLK3.27903942
6PDGFRA3.26342019
7TIE13.24460036
8EPHB23.16835005
9TRIB32.87447365
10MET2.78225833
11LATS12.61944293
12TTN2.47564088
13PTK2B2.47363951
14BMX2.16260605
15ERN12.10416095
16LRRK22.06736981
17RIPK11.90788015
18DMPK1.83973609
19NTRK11.81688492
20GRK11.74977864
21ILK1.72214563
22FER1.67989378
23PDGFRB1.67547740
24NUAK11.67382987
25TESK11.60638875
26PTK61.51366390
27MAPK71.49718624
28PTK21.46621037
29SIK11.44689306
30ROCK11.42826383
31TGFBR11.42673180
32PAK41.38977374
33PAK21.38821419
34MAP3K61.35514021
35CDK81.28029024
36FGFR21.26301810
37CSF1R1.24928698
38PKN21.23726069
39ABL21.11458137
40PIK3CG1.10100004
41PRKCE1.05803962
42MAP3K101.04987525
43NLK1.00158385
44ROCK20.97765932
45CDK120.94513882
46ADRBK20.92602641
47AKT30.92543320
48EEF2K0.91540450
49PRKG20.91296326
50LMTK20.90673209
51PRKCH0.90357058
52STK380.88362836
53PRKD10.86169524
54JAK10.85908616
55MAPKAPK30.85686849
56PRPF4B0.85449133
57FGR0.84964848
58FGFR10.84185465
59MTOR0.84076043
60PRKD20.82917630
61ADRBK10.80402120
62STK30.79924199
63FGFR40.79546309
64TYK20.78453436
65EPHB10.78443871
66LIMK10.77481432
67TRPM70.76393581
68PRKCZ0.74133761
69ICK0.70658321
70RET0.70429379
71GRK70.70142543
72GSK3A0.68613470
73WNK10.68419774
74GRK60.65771314
75MARK20.65141965
76MOS0.62951007
77ERBB20.62450364
78MAPK40.61539838
79PRKAA20.60910940
80NEK90.60526766
81CLK10.60165674
82DAPK30.58095296
83SRC0.51459227
84PAK30.51032766
85FLT30.50742493
86MAPK120.48649972
87PAK10.48592183
88INSR0.48446329
89HIPK20.48122515
90MKNK10.47838951
91STK38L0.46904292
92CAMK1D0.46419251
93ZAP700.45267845
94MAP2K10.44711098
95EIF2AK10.44446319
96CAMK1G0.44293068
97MAPK10.42795459
98CAMK10.42608939
99IGF1R0.42522063
100PDPK10.42324677
101MKNK20.42259396
102MAP3K70.42067934
103TLK10.41993188
104PIM20.41774679
105PIK3CA0.40702853
106PRKD30.40008148
107DYRK1B0.38759484
108CDC42BPA0.37923780
109PLK20.37109895
110ERBB30.37054406
111PHKG20.36602648
112PHKG10.36602648
113MELK0.35787842
114CAMK2G0.34815075
115RPS6KC10.33301349
116RPS6KL10.33301349
117DAPK20.33131764
118TBK10.32979817
119RPS6KA40.32658643
120ACVR1B0.31409152
121MAP2K20.31206440
122CSK0.31015087
123MAPKAPK20.29882033
124KIT0.27775624
125CDK70.26701377
126MAP3K30.26193020
127RPS6KA60.25372168
128CDK60.24650409
129DYRK20.23311347
130RPS6KA20.22483794
131GRK50.21385025
132PRKG10.20134852
133FYN0.19490951
134CSNK1A1L0.19076203
135FGFR30.18630636
136STK100.18543084
137AKT20.18458445

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.34418438
2Basal cell carcinoma_Homo sapiens_hsa052173.32065672
3Focal adhesion_Homo sapiens_hsa045103.09405768
4Protein digestion and absorption_Homo sapiens_hsa049743.00251911
5Hedgehog signaling pathway_Homo sapiens_hsa043402.84352877
6Adherens junction_Homo sapiens_hsa045202.41796564
7Hippo signaling pathway_Homo sapiens_hsa043902.33290220
8Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.25412360
9Glycosaminoglycan degradation_Homo sapiens_hsa005312.24640209
10AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.23900222
11Dilated cardiomyopathy_Homo sapiens_hsa054142.16413488
12TGF-beta signaling pathway_Homo sapiens_hsa043502.15121035
13Proteoglycans in cancer_Homo sapiens_hsa052052.11708730
14Amoebiasis_Homo sapiens_hsa051462.10377681
15Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.06970354
16Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.02829237
17Small cell lung cancer_Homo sapiens_hsa052221.90206583
18Axon guidance_Homo sapiens_hsa043601.85548555
19Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.78454571
20PI3K-Akt signaling pathway_Homo sapiens_hsa041511.64704306
21Pathways in cancer_Homo sapiens_hsa052001.57127980
22Wnt signaling pathway_Homo sapiens_hsa043101.54020352
23Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.52918701
24Cyanoamino acid metabolism_Homo sapiens_hsa004601.46593409
25MicroRNAs in cancer_Homo sapiens_hsa052061.45984145
26Malaria_Homo sapiens_hsa051441.45610711
27Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.41851821
28Staphylococcus aureus infection_Homo sapiens_hsa051501.29896512
29Regulation of actin cytoskeleton_Homo sapiens_hsa048101.29433847
30Tight junction_Homo sapiens_hsa045301.27480737
31Other glycan degradation_Homo sapiens_hsa005111.27254964
32Fat digestion and absorption_Homo sapiens_hsa049751.26939970
33Leukocyte transendothelial migration_Homo sapiens_hsa046701.26455280
34Melanogenesis_Homo sapiens_hsa049161.26428501
35Bladder cancer_Homo sapiens_hsa052191.25007132
36Viral myocarditis_Homo sapiens_hsa054161.24816082
37Vascular smooth muscle contraction_Homo sapiens_hsa042701.23718425
38Chronic myeloid leukemia_Homo sapiens_hsa052201.19756026
39Rap1 signaling pathway_Homo sapiens_hsa040151.19206141
40Platelet activation_Homo sapiens_hsa046111.18896244
41Mineral absorption_Homo sapiens_hsa049781.15184895
42Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.14798683
43Histidine metabolism_Homo sapiens_hsa003401.13467321
44Melanoma_Homo sapiens_hsa052181.13390144
45Prostate cancer_Homo sapiens_hsa052151.12624500
46Notch signaling pathway_Homo sapiens_hsa043301.11393567
47Renin secretion_Homo sapiens_hsa049241.10447750
48cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09295826
49Lysine degradation_Homo sapiens_hsa003101.08652607
50Insulin resistance_Homo sapiens_hsa049311.08289943
51Complement and coagulation cascades_Homo sapiens_hsa046101.02330370
522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.01068403
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.95004076
54HTLV-I infection_Homo sapiens_hsa051660.88112990
55Tyrosine metabolism_Homo sapiens_hsa003500.86502644
56Endometrial cancer_Homo sapiens_hsa052130.85416468
57Lysosome_Homo sapiens_hsa041420.85285262
58Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.82960892
59Phenylalanine metabolism_Homo sapiens_hsa003600.81094901
60Vitamin digestion and absorption_Homo sapiens_hsa049770.80990303
61Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.80848125
62Gap junction_Homo sapiens_hsa045400.78686615
63Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.77839737
64Colorectal cancer_Homo sapiens_hsa052100.77303507
65Renin-angiotensin system_Homo sapiens_hsa046140.76193440
66Arachidonic acid metabolism_Homo sapiens_hsa005900.75871014
67Sulfur metabolism_Homo sapiens_hsa009200.75815210
68Toxoplasmosis_Homo sapiens_hsa051450.75410247
69Glutathione metabolism_Homo sapiens_hsa004800.75220136
70Glioma_Homo sapiens_hsa052140.74567278
71Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.74021750
72Glycerolipid metabolism_Homo sapiens_hsa005610.73706464
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73466260
74Pancreatic cancer_Homo sapiens_hsa052120.71213705
75Ovarian steroidogenesis_Homo sapiens_hsa049130.71167773
76Estrogen signaling pathway_Homo sapiens_hsa049150.70657248
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.70489261
78Transcriptional misregulation in cancer_Homo sapiens_hsa052020.70344257
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.70197714
80Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.69726006
81Renal cell carcinoma_Homo sapiens_hsa052110.67323474
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.66316751
83Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64875411
84Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64140560
85Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.62300144
86Aldosterone synthesis and secretion_Homo sapiens_hsa049250.62159639
87Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.60270402
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.59752240
89Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.58682702
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.56412400
91Thyroid hormone synthesis_Homo sapiens_hsa049180.55997834
92N-Glycan biosynthesis_Homo sapiens_hsa005100.55736308
93Chemical carcinogenesis_Homo sapiens_hsa052040.55642245
94Ras signaling pathway_Homo sapiens_hsa040140.55253416
95FoxO signaling pathway_Homo sapiens_hsa040680.55116664
96cAMP signaling pathway_Homo sapiens_hsa040240.54654063
97Oxytocin signaling pathway_Homo sapiens_hsa049210.49851569
98PPAR signaling pathway_Homo sapiens_hsa033200.48975563
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.48890534
100Arginine biosynthesis_Homo sapiens_hsa002200.46885388
101Bile secretion_Homo sapiens_hsa049760.46197799
102Endocytosis_Homo sapiens_hsa041440.45716956
103alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45468822
104Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45408298
105Fatty acid degradation_Homo sapiens_hsa000710.44552594
106Insulin signaling pathway_Homo sapiens_hsa049100.44354455
107Prion diseases_Homo sapiens_hsa050200.43915199
108Selenocompound metabolism_Homo sapiens_hsa004500.43446420
109Tryptophan metabolism_Homo sapiens_hsa003800.43418063
110TNF signaling pathway_Homo sapiens_hsa046680.43142189
111VEGF signaling pathway_Homo sapiens_hsa043700.42873047
112Fatty acid elongation_Homo sapiens_hsa000620.42870142
113Thyroid cancer_Homo sapiens_hsa052160.41055828
114mRNA surveillance pathway_Homo sapiens_hsa030150.40917816
115Galactose metabolism_Homo sapiens_hsa000520.40025379
116Calcium signaling pathway_Homo sapiens_hsa040200.39632324
117GnRH signaling pathway_Homo sapiens_hsa049120.39134272
118Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.39000689
119Phagosome_Homo sapiens_hsa041450.37010279
120Neurotrophin signaling pathway_Homo sapiens_hsa047220.36212573
121Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.36168857
122Dorso-ventral axis formation_Homo sapiens_hsa043200.36095753
123Retinol metabolism_Homo sapiens_hsa008300.33735550
124MAPK signaling pathway_Homo sapiens_hsa040100.32212992
125Hepatitis B_Homo sapiens_hsa051610.31257087
126Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.30547868
127Fatty acid metabolism_Homo sapiens_hsa012120.30499882
128AMPK signaling pathway_Homo sapiens_hsa041520.30462532
129Gastric acid secretion_Homo sapiens_hsa049710.29493082
130Cocaine addiction_Homo sapiens_hsa050300.29173041
131Jak-STAT signaling pathway_Homo sapiens_hsa046300.27260009
132Pertussis_Homo sapiens_hsa051330.25952657

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